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| 1 | Effect of Lichong decoction on expression of Bcl-2 and Bcl-2-associated X protein mRNAs in hysteromyoma model rat显示文摘OBJECTIVE:To study on effects of Lichong decoction on expression of apoptosis-controlling genes,Bcl-2 and Bcl-2-associated X protein(Bax) mRNAs in hysteromyoma tissue of the hysteromyoma model rat.METHODS:Fifty Wistar female rats were randomly divided into a normal group,a model group,a Lichong decoction group,a Guizifuling capsule group and a Mifepristone group.The hysteromyoma rat model was established by intraperitoneal injection of exogenous estrin and progestogens.Pathological examination of uterine tissue,uterine coefficient and uterine transverse diameter were made under optic microscope and expressions of Bcl-2 and Bax mRNAs in uterine tissue in the groups were detected with real-time fluorescent quantitative polymerase chain reaction(PCR) technique.RESULTS:After treatment,under microscope it was found that in the Lichong decoction group myometrium thinned,muscle fiber slightly overgrowth or long and thin,regular arrangement,inserting phenomenon of inner circular muscle and external longitudinal muscle was occasionally or not seen in the Lichong decoction group.The uterine coefficient and the uterine transverse diameter significantly decreased(P<0.01),and Bcl-2 mRNA expression significantly decreased(P<0.01) and Bax mRNA expression significantly increased in hysteromyoma tissue(P<0.01) in the Lichong decoction group as compared with the model group.CONCLUSION:Therapeutic effects of Lichong decoction on hysteromyoma is related with decrease of Bcl-2 mRNA expression and increase of Bax mRNA expression. | Donghua Li Xin Xu Ruiya Qian Jianguo Geng Yan Zhang Xiaolei Xie Yasong Wang Xiaoli Zou | 2013 | Journal of Traditional Chinese Medicine2013，33，2： | 24 |
| 2 | Hierarchical Control of Ride Height System for Electronically Controlled Air Suspension Based on Variable Structure and Fuzzy Control Theory显示文摘The current research of air suspension mainly focuses on the characteristics and design of the air spring. In fact, electronically controlled air suspension(ECAS) has excellent performance in flexible height adjustment during different driving conditions. However, the nonlinearity of the ride height adjusting system and the uneven distribution of payload affect the control accuracy of ride height and the body attitude. Firstly, the three-point measurement system of three height sensors is used to establish the mathematical model of the ride height adjusting system. The decentralized control of ride height and the centralized control of body attitude are presented to design the ride height control system for ECAS. The exact feedback linearization method is adopted for the nonlinear mathematical model of the ride height system. Secondly, according to the hierarchical control theory, the variable structure control(VSC) technique is used to design a controller that is able to adjust the ride height for the quarter-vehicle anywhere, and each quarter-vehicle height control system is independent. Meanwhile, the three-point height signals obtained by three height sensors are tracked to calculate the body pitch and roll attitude over time, and then by calculating the deviation of pitch and roll and its rates, the height control correction is reassigned based on the fuzzy algorithm. Finally, to verify the effectiveness and performance of the proposed combined control strategy, a validating test of ride height control system with and without road disturbance is carried out. Testing results show that the height adjusting time of both lifting and lowering is over 5 s, and the pitch angle and the roll angle of body attitude are less than 0.15?. This research proposes a hierarchical control method that can guarantee the attitude stability, as well as satisfy the ride height tracking system. | XU Xing ZHOU Kongkang ZOU Nannan JIANG Hong CUI Xiaoli | 2015 | Chinese Journal of Mechanical Engineering2015，28，5： | 13 |
| 3 | Lichong decoction reduces Matrix Metalloproteinases-2 expression but increases Tissue Inhibitors of Matrix Metalloproteinases-2 ex-pression in a rat model of uterine leiomyoma显示文摘OBJECTIVE:To study the effect of Lichong decoction(LD) on expression of matrix metalloproteinase-2(MMP-2) and metalloproteinase-2(TIMP-2) in a rat model of uterine leiomyoma(UL).METHODS:UL was induced in rats using exogenous estrogen and progesterone.LD was administered(p.o.) for 4 weeks,and mifepristone(RU-486)used as a control.To observe the effect of LD on the uterine coefficient and uterine transverse diameter,a radioimmunoassay method was used to detect serum levels of sex hormones.Light microscopic analyses of pathologic changes in the tissues of UL rats were evaluated.Expression of the proteins of matrix metalloproteinases(MMPs) and tissue inhibitors of metalloproteinases(TIMPs) in uterine tissues was assessed by immunohistochemical staining and western blotting.RESULTS:A UL model in rats was established successfully.LD reduced uterine weight,uterine coefficient,and uterine transverse diameter compared with untreated controls.LD reduced levels of estradiol,progesterone,follicle-stimulating hormone,and luteinizing hormone in our UL models.LD improved the pathologic condition of uterine muscle.Expression of MMP-2 protein decreased to varying extents in LD-treated groups,but TIMP-2 levels were enhanced.LD appears to reduce MMP-2 expression and increase TIMP-2 expression in UL tissue.CONCLUSION:These data suggest that the mechanism of action of LD on ULs may involve reduction of MMP-2 expression and increase in TIMP-2 expression in rats. | Wang Yasong Li Donghua Xu Xin Qian Ruiya Zhang Yalan Huang Yuhua Geng Jianguo Zou Xiaoli Han Hon-gjuan Zhang Wufang | 2016 | Journal of Traditional Chinese Medicine2016，36，4： | 12 |
| 4 | Effect of Lichong Decoction on expression of IGF-I and proliferating cell nuclear antigen mRNA in rat model of uterine leiomyoma显示文摘OBJECTIVE:To study the effect of Lichong Decoction(Lichong Decoction for strengthening anti-pathogenic Qi and eliminating blood stasis) on the expression of insulin-like growth factor-I(IGF-I) and proliferating cell nuclear antigen(PCNA) mRNA in a rat model of uterine leiomyoma.METHODS:Fifty female Wistar rats were randomized into a normal control group,model group,Lichong Decoction group,Guizhifuling Capsule(Capsule containing Cassia Twig and Poria) group,and Mifepristone group.The uterine leiomyoma model was established by peritoneal injections of exogenous estrogen and progesterone hormone.The ultrastructural changes in cells of rat uterine tissues were observed with transmission electron microscopy,and the expression of IGF-I and PCNA mRNA was detected by real-time fluorescent quantitative PCR.RESULTS:Following treatment,cells in the Lichong Decoction group appeared to be arranged normally,the cellular morphology were almost in a normal state,hyperplasia and hypertrophy of the chondriosome was reduced,collagen fibers were arranged in a regular manner,without obvious hyperplasia,and the expression of IGF-I and PCNA mRNA was significantly decreased compared with the model group(P<0.01).CONCLUSIONS:The effect of Lichong Decoction on uterine leiomyoma is related to its function in reducing the expression of IGF-I and PCNA mRNA. | Donghua Li Yalan Zhang Hongjuan Han Jianguo Geng Xiaolei Xie Jiubo Zheng Yasong Wang Xiaoli Zou | 2012 | Journal of Traditional Chinese Medicine2012，32，4： | 11 |
| 5 | Isolation and identification of sinapine-degrading bacteria from the intestinal tract of laying hens显示文摘This study was aimed to isolate sinapine-degrading bacteria from the intestinal tract of laying hens and to identify the predominant bacteria. Thirty-week old healthy laying hens were killed, and the chyme in the digestive tract was inoculated into modified Czapek medium containing sinapin and cultivated at 37 ℃for 10 days. The optical density(OD) values of the bacterial solutions at different cultivating times were detected by a spectrophotometric method. The predominant strains were identified by 16 S rRNA gene analysis. We extracted the extracellular products of the predominant strains to determine the total protein using the Coomassie brilliant blue method, and to determine the activities of some extracellular enzymes using the agar plate diffusion method. Nine strains were isolated from the lower intestinal tract of laying hens. Among the 9 strains, 5 were from the ileum, 2 were from the ceca and 2 were from the jejunum. We could not isolate any strains from the upper intestinal tract, such as the stomach and duodenum. Eight of those 9 isolated strains were gram negative and one was gram positive. Strains YD-1 and YD-2 were better than other strains in their abilities to degrade sinapine. Strains YD-1 and YD-2 were identified as Escherichia coli and Klebsiella spp., respectively, by the 16 S rRNA sequence analysis.The total protein level of the extracellular products was 1.213 g/L for YD-1 and 1.990 g/L for YD-2. Both extracellular products of YD-1 and YD-2 had the activities of protease, amylase and urease. This study confirmed that the primary site of sinapine degradation is in the lower intestinal tract of laying hens. The sinapine-degrading strains are mainly gram negative. Strains YD-1 and YD-2 are predominant in degrading sinapine and they belong to E. coli and Klebsiella spp., respectively. Both extracellular products of YD-1 and YD-2 contain protease, amylase and urease. Strain YD-2 is better than strain YD-1 in its ability to degrade sinapine. | Dan Yu Xiaoli Huang Chengyi Zou Bin Li Jing Duan Qin Yin | 2016 | Animal Nutrition2016，，1： | 5 |
| 6 | A static resistance model and the discontinuous pattern of hydrocarbon accumulation in tight oil reservoirs显示文摘In exploration for tight oil, the content and saturation of hydrocarbon in the tight reservoir is a key factor for evaluating the reserve. Therefore, it is necessary to study the geological history of hydrocarbon accumulation and the tight oil charging process. However, kinetic models used for petroleum development are not applicable for petroleum exploration. In this study, a static resistance model is proposed after analyzing resistances in ultra-slow flow in porous media. Using this model, the discontinuous pattern of oil charging is reproduced through incompressible Navier-Stokes equations, the phase field method and the finite element method. This study also explains macroscopic percolation behavior with microscopic flow mechanisms and discusses some issues in ultra-slow flow in a micro/nano pore-throat network. The resistance analysis reveals that capillary resistance and dissipation resistance are dominant factors in the mechanism of oil accumulation in tight reservoirs. Numerical simulations show that pressure thresholds exist and result in discontinuous oil charging. Generally, it is proven that the static model is more applicable than kinetic models in describing oil accumulation in tight reservoirs. | Sun Liang Zou Caineng Liu Xiaoli Zhu Rukai Wang Xiaoqi | 2014 | Petroleum Science2014，11，4： | 5 |
| 7 | The clinical study of ultrasound-guided intra-hysteromyoma injection of ethyl alcohol absolute combined with HIFU in the treatment of uterine fibroids显示文摘Objective The aim of this study was to investigate the energy deposition in the target area of high intensity focused ultrasound(HIFU) with ultrasound-guided intra-hysteromyoma injection of ethyl alcohol absolute Methods Eighty patients with hysteromyomas were randomly divided into two groups: group HIFU(group H) and group HIFU combined with ultrasound-guided intra-hysteromyoma injectionn of ethyl alcohol absolute(group E + H). Patients in group E + H received an ultrasound-guided injection of absolute ethyl alcohol 1 h before HIFU treatment. The irradiation time, irradiation dose, energy efficiency factor(radiation energy required for ablation of a myoma per unit of volume), grey variation, pain score, and adverse reactions were compared between the two groups. An independent sample t-test was used with a twotailed P-value of < 0.05.Results The irradiation time, irradiation dose, and energy efficiency factor were significantly lower in group E + H than those in group H(P < 0.05). The hysteromyomas of patients in group E+H appeared as dominantly hyperechoic masses, and those of patients in group H appeared as hyperechoic tissue(nonmass). The incidence of adverse reactions and pain score were higher in group H than those in group E + H(P < 0.05).Conclusion Ultrasound-guided intra-hysteromyoma injection of ethyl alcohol absolute can enhance the energy deposition of HIFU in the uterine fibroids, improve the treatment efficiency, shorten the treatment time, reduce the treatment dose, and reduce the pain and complications for the patients. | Xiaoli Zou Baixin Sun Li Jia Xiaobei Liu | 2018 | Oncology and Translational Medicine2018，4，5： | 5 |
| 8 | A strategy with label-free quantification of the targeted peptides for quantitative peptidome analysis of human serum显示文摘Peptidomics draws more and more attention in discovering useful biomarkers for early diagnosis of disease. However, there is lack of efficient quantification strategy in peptidome analysis. In this study, a strategy with label-free quantification of the targeted endogenous peptides based on peak intensity using μUPLC-Q-TOF-MS/MS was developed for quantitative peptidome analysis of human serum. Different amounts of standard BSA tryptic digesting peptides were added into the same serum extracts for evaluation of the developed strategy, and it was observed that the average relative error of the targeted peptides was 6.42%, which was superior to the result obtained directly by commercially available software PLGS. It was also demonstrated that this quantification strategy could obviously increase the detection sensitivity of the peptide by DDA analysis. Then, this strategy was applied to comparatively analyze the peptides extracted from the serum of HCC or breast cancer patients and healthy individuals, respectively. Peptides with charge states up to 5 and molecular weight over 4000 can be reliably identified and quantified. This quantitative analysis method based on μUPLC-Q-TOF-MS/MS exhibited superior sensitivity than that by MALDI-TOF-MS commonly used in peptidome analysis. Finally, some interesting endogenous peptides related to corresponding diseases were successfully obtained. | ZHU Jun, WANG FangJun, DONG XiaoLi, YE MingLiang & ZOU HanFa Key Laboratory of Separation Sciences for Analytical Chemistry National Chromatographic Research and Analysis Center Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China | 2010 | Science China Chemistry2010，53，4： | 3 |
| 9 | Anti-NLRP3 inflammasome abietane diterpenoids from Callicarpa bodinieri and their structure elucidation显示文摘Callica rpabodinieri is a Chinese traditional medicine herb with anti-inflammatory activity in clinic.Herein,we report two new 9,10-seco and etherified abietane diterpenoids bodinieric acids J and K(1 and 2) and one known compound(3) isolated from the leaves and twigs of this plant.Their chemical structures were elucidated by detailed spectrometry data analysis and DP4+NMR calculation methods.Hypothetical biosynthetic pathways of 1-3 were preliminarily speculated.Compound 3 inhibited inflammasome activation and exhibited blockage of NLRP3 inflammasome activation at non-cytotoxic concentrations in vitro. | Junbo Gao Xingjie Zhang Kun Shang Weimao Zhong Ruihan Zhang Xiaochang Dai Xiaoli Li Qi Wang Yan Zou Weilie Xiao | 2020 | Chinese Chemical Letters2020，31，2： | 3 |
| 10 | Ribbon-like Cu doped V6O13 as Cathode Material for High-performance Lithium Ion Batteries显示文摘Ribbon-like Cu doped V_6O_(13) was synthesized via a simple solvothermal approach followed by heat treatment in air.As an cathode material for lithium ion battery,the ribbon-like Cu doped V_6O_(13 )electrode exhibited good capacity retention with a reversible capacity of over 313 m Ah?g^(-1) for up to 50 cycles at 0.1C,as well as a high charge capacity of 306 m Ah?g^(-1) at a high current rate of 1 C,in comparison to undoped V_6O_(13 )electrode(267 m Ah?g^(-1) at 0.1C and 273 m Ah?g^(-1) at 1 C).The high rate capability and better cycleability of the doped electrode can be attributed to the influence of the Cu ions on the mophology and the electronic conductivity of V_6O_(13) during the lithiation and delithiation process. | 何金云 龙飞 PENG Daijiang WU Xiaoli MO Shuyi ZOU Zhengguang | 2017 | Journal of Wuhan University of Technology(Materials Science)2017，32，6： | 3 |
| 11 | Applications of controlled inversion strategies in carbohydrate synthesis显示文摘Carbohydrates play critical roles in mediating many biological processes, such as cell growth, migration,cell-cell adhesion, fertilization, signal transduction and immune response. The increasing demands for the study of these molecules greatly facilitate the development of carbohydrate synthesis. Inversion strategies via sulfonyl groups, selective reductions, etc. have been used to synthesize corresponding inverted configurations. This review focuses on the mechanisms of these inversion methods and their applications in constructing amino sugars, rare sugars and β-configurations in glycosylations. | Wuqiong Song Juntao Cai Xiaopeng Zou Xiaoli Wang Jing Hu Jian Yin | 2018 | Chinese Chemical Letters2018，29，1： | 3 |
| 12 | 甲状腺乳头状癌后方回声衰减及颈部淋巴结转移囊性变的病理学研究(英文)显示文摘Objective: The aim of our study was to evaluate the pathological features of posterior echo attenuation of papillary thyroid microcarcinoma (PTMC) and cystic degeneration of cervical lymph node metastasis. Methods: We retrospectively evaluated the ultrasound results from 36 cases of PTMC with 20 nodules of cystic degeneration of cervical lymph node metastasis and correlated the results with the histopathologic findings. Results: The preliminary study indicated certain correlation between histopathologic findings and ultrasound results of posterior echo attenuation of papillary thyroid microcarcinoma and cystic degeneration of cervical lymph node metastasis. Conclusion: Posterior echo attenuation detected by ultrasound was associated with fibrous structures in PTMC nodules, while cystic degeneration and papillary changes of cervical lymph node metastasis in PTMC showed liquefactive necrosis, degenerative changes and enlarged follicular of nodular structures. | Xiaoli Zou Chunxiang Huang Xiaojun Gao | 2013 | The Chinese-German Journal of Clinical Oncology2013，12，7： | 2 |
| 13 | Interface engineering of high performance all-inorganic perovskite solar cells via low-temperature processed TiO2 nanopillar arrays显示文摘All-inorganic perovskite solar cells suffer from low performance due to unsatisfactory carrier transport and light harvesting efficiency.Semiconductor nanopillar arrays can reduce light reflection loss and suppress exciton recombination dynamics in optoelectronic devices.In all-inorganic perovskite solar cells,few studies employing TiO_(2)nanopillar arrays(TiO_(2)NaPAs)have been reported to improve the device performance.Herein,well-arranged TiO_(2)NaPAs are chosen to enhance the interfacial contact between perovskite and electron transporting layers for improving the carrier transport.Notably,TiO_(2)NaPAs can be directly fabricated on rigid/flexible substrates at roughly room temperature by unique glancing angle deposition,which is more available than high-temperature hydrothermal/solvothermal methods.By embedding TiO_(2)NaPAs into chemical processable CsPbI2Br layers,continuous and intimate films are readily formed,guaranteeing large physical contact for facilitating more effective electron injection and charge separation.The vertically grown TiO_(2)NaPAs also provide a straightforward electron transporting path to electrodes.In addition,TiO_(2)NaPAs can guide the incident light and enhance the light-harvesting ability of CsPbI2Br films.As a result,the solar cell with TiO_(2)NaPAs displays a power conversion efficiency of 11.35%higher than planar control of 10.04%,and exhibits better long-term thermal stability.This strategy provides an opportunity by constructing direct interfacial regulation towards the performance improvement of inorganic perovskite solar cells. | Bingkun Pan Jiahao Gu Xiaoli Xu Lingbo Xiao Jie Zhao Guifu Zou | 2021 | Nano Research2021，14，10： | 2 |
| 14 | Investigation of high extraction efficiency flip-chip GaN-based light-emitting diodes显示文摘In order to obtain higher light output power, the flip-chip structure is used. We studied the ratio of the light of GaN sides before and after fabricating metal reflector on p-GaN. The SiO2/SiNx dielectric film reflectors were deposited through plasma enhance chemical vapor deposition following the fabrication of metal reflector, and then the dielectric film reflectors on the electrodes were etched in order to expose the electrodes to the air. It is found that comparing with the flip-chip GaN-LED without dielectric film reflectors, light output power can be increased by as high as 10.2% after the deposition of 2 pairs of SiO2/SiNx dielectric film reflectors on GaN-LEDs, which cover the sidewalls and the areas without the metal reflector. This result indicates that the high reflector formed by multi-layer dielectric films is useful to enhance the light output power of GaN-based LED, which reflects light from step sidewalls and p-GaN without metal reflector to internal, and then light emits from the surface. | DA XiaoLi SHEN GuangDi XU Chen ZOU DeShu ZHU YanXu ZHANG JianMing | 2009 | Science in China(Series F)2009，52，8： | 2 |
| 15 | Effects of different aperture-sized type I collagen/silk fibroin scaffolds on the proliferation and differentiation of human dental pulp cells显示文摘This study aimed at evaluate the effects of different aperture-sized type I collagen/silk fibroin(CSF)scaffolds on the proliferation and differentiation of human dental pulp cells(HDPCs).The CSF scaffolds were designed with 3D mapping software Solidworks.Three different aperture-sized scaffolds(CSF1-CSF3)were prepared by low-temperature deposition 3D printing technology.The morphology was observed by scanning electron microscope(SEM)and optical coherence tomography.The porosity,hydrophilicity and mechanical capacity of the scaffold were detected,respectively.HDPCs(third passage,1105 cells)were seeded into each scaffold and investigated by SEM,CCK-8,alkaline phosphatase(ALP)activity and HE staining.The CSF scaffolds had porous structures with macropores and micropores.The macropore size of CSF1 to CSF3 was 421627 lm,579636 lm and 707643 lm,respectively.The porosity was 69.862.2%,80.162.8%and 86.563.3%,respectively.All these scaffolds enhanced the adhesion and proliferation of HDPCs.The ALP activity in the CSF1 group was higher than that in the CSF3 groups(P<0.01).HE staining showed HDPCs grew in multilayer within the scaffolds.CSF scaffolds significantly improved the adhesion and ALP activity of HDPCs.CSF scaffolds were promising candidates in dentine-pulp complex regeneration. | Shihui Jiang Zhaoxia Yu Lanrui Zhang Guanhua Wang Xiaohua Dai Xiaoli Lian Yan Yan Linpu Zhang Yue Wang Ruixin Li Huiru Zou | 2021 | Regenerative Biomaterials2021，8，4： | 2 |
| 16 | Gold nanoparticles based digital color analysis for quinidine detection显示文摘In this contribution,we developed a novel digital color analysis of gold nanoparticles(AuNPs) for pharmaceutical detection by choosing quinidine as an example.It was found that the color of AuNPs colloid solution changed from red to blue in the presence of different concentrations of quinidine,and the color information of each solution could be digitalized with tricolor(RGB) system.Under the optimum conditions,the R value of the solution was found to be linear with the natural logarithm of concentration of quinidine in the range of 112 384 nmol/L.This method has the advantages of rapid,economical and simple,and can serve as a potential alternative to traditional spectrophotometry for practical use. | ZOU BoZhou LIU Yue YAN XiaoLi HUANG ChengZhi | 2013 | Chinese Science Bulletin2013，58，18： | 2 |
| 17 | Microstructure and emission properties of nanometer Ce-W material显示文摘 | Xiaoli Xi Zuoren Nie Jingxia Zou Jiancan Yang Tieyong Zuo | 2006 | Journal of Alloys and Compounds2006，，1： | 1 |
| 18 | Synergistic degradation of antibiotic sulfadiazine in a heterogeneous ultrasound-enhanced Fe°/persulfate Fenton-like system显示文摘 | Zou Xiaoli Zhou Tao Mao Juan | 2014 | Chemical Engineering Journal2014，257，： | 1 |
| 19 | Amperometric biosensor for NADH and ethanol based on electroreduced graphene oxide–polythionine nanocomposite film显示文摘 | Zou Li Yi Huang Li Chen Xiaoli Qin Zhao Huang Yaping Zhou Yue Meng Jing Li Siyu Huang Yan Liu Wen Wang Qingji Xie Shouzhuo Yao | 2013 | Sensors & Actuators: B Chemical2013，，： | 1 |
| 20 | Stability factors for rockslopes subjected to pore water pressure based on theHoek-Brown failure criterion 显示文摘 | Yang Xiaoli Zou Jingfeng | 2006 | International Journal ofRock Mechanics & Mining Sciences2006，43，6： | 1 |
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