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| 1 | Population Genomic Analysis and De Novo Assembly Reveal the Origin of Weedy Rice as an Evolutionary Game显示文摘Crop weediness,especially that of weedy rice(Oryza sativa f.spontanea),remains mysterious.Weedy rice possesses robust ecological adaptability;however,how this strain originated and gradually formed proprietary genetic features remains unclear?Here,we demonstrate that weedy rice at Asian high latitudes(WRAH)is phylogenetically well defined and possesses unselected genomic characteristics in many divergence regions between weedy and cultivated rice.We also identified novel quantitative trait loci underlying weedy-specific traits,and revealed that a genome block on the end of chromosome 1 is associated with rice weediness.To identify the genomic modifications underlying weedy rice evolution,we generated the first de novo assembly of a high-quality weedy rice genome(WR04-6),and conducted a comparative genomics study between WR04-6 with other rice reference genomes.Multiple lines of evidence,including the results of demographic scenario comparisons,suggest that differentiation between weedy rice and cultivated rice was initiated by genetic improvement of cultivated rice and that the essence of weediness arose through semi-domestication.A plant height model further implied that the origin of WRAH can be modeled as an evolutionary game and indicated that strategy-based selection driven by fitness shaped its genomic diversity. | Jian Sun Dianrong Ma Liang Tang Minghui Zhao Guangchen Zhangh Wenjia Wang Jiayu Song Xiang Li Zimeng Liu Wenxing Zhang Quan Xu Yuncheng Zhou Jianzhong Wu Toshio Yamamoto Fei Dai Yan Lei Song Li Gang Zhou Hongkun Zheng Zhengjin Xu Wenfu Chen | 2019 | Molecular Plant2019，12，5： | 9 |
| 2 | Efficient alloy design of Sr-modified A356 alloys driven by computational thermodynamics and machine learning显示文摘A356 alloys are widely used in industries due to their excellent comprehensive performance.Sr is usually added in A356 alloys to improve their mechanical properties.There have been various experimental reports on the optimal additional amount of Sr in A356 alloys,but their results are inevitably inconsistent.In this paper,a combination of computational thermodynamic and machine learning approaches was employed to determine the optimal Sr content in A356 alloys with the best mechanical properties.First,a self-consistent thermodynamic database of quaternary Al-Si-Mg-Sr system was established by means of the Calculation of PHAse Diagram technique supported by key experiments.Second,the fractions for solidified phase/structures of A356-xSr alloys predicted by Scheil simulation,together with the measured mechanical properties were set as the input dataset in the machine learning model to train the relation of“composition-microstructure-properties”.The optimal addition of Sr in A356 alloy was designed as 0.005 wt.%and validated by key experiments.Furthermore,such a combinatorial approach can help to understand the strengthening/toughening mechanisms of Sr-modified A356 alloys.It is also anticipated that the present approach may provide a feasible means for efficient and accurate design of various casting alloys and understanding the alloy strengthening/toughening mechanisms. | Wang Yi Guangchen Liu Zhao Lu Jianbao Gao Lijun Zhang | 2022 | Journal of Materials Science & Technology2022，，17： | 3 |
| 3 | Preliminary Results of Acoustic Radiation Force Impulse (ARFI) Ultrasound Imaging of Breast Lesions显示文摘 | Wei Meng Guangchen Zhang Changjun Wu Guozhu Wu Yan Song Zhaoling Lu | 2011 | Ultrasound in Medicine & Biology2011，，9： | 2 |
| 4 | Preliminary Results of Acoustic Radiation Force Impulse (ARFI) Ultrasound Imaging of Breast Lesions显示文摘 | Wei Meng Guangchen Zhang Changjun Wu Guozhu Wu Yan Song Zhaoling Lu | 2011 | Ultrasound in Medicine & Biology2011，，9： | 2 |
| 5 | iTRAQ-Based Proteomics Investigation of Critical Response Proteins in Embryo and Coleoptile During Rice Anaerobic Germination显示文摘Direct-seeding of rice has become popular in recent years due to its low cost and convenience,however,hypoxic condition limits seedling establishment.In this study,weedy rice WR04-6 with high germination ability under anaerobic conditions was used as a gene donor,and we successfully improved the seedling establishment rate of rice cultivar Qishanzhan(QSZ)based on selection of a new rice line R42 from the recombinant inbred line population.R42 inherited high anaerobic germination(AG)ability,and was used for isobaric tags for relative and absolute quantitation(iTRAQ)-based comparative proteomic studies with QSZ to further explore the molecular mechanism of AG.A total of 719 differentially abundant proteins(DAPs)were shared by R42 and QSZ responded to AG,and thus defined as common response DAPs.A total of 300 DAPs that responded to AG were only identified from R42,which were defined as tolerance-specific DAPs.The common response and tolerance-specific DAPs had similar biochemical reaction processes and metabolic pathways in response to anoxic stress,however,they involved different proteins.The tolerance-specific DAPs were involved in amino acid metabolism,starch and sucrose metabolism,tricarboxylic acid cycle pathway,ethylene synthesis pathway,cell wall-associated proteins and activity of active oxygen scavenging enzyme.The in silico protein-protein interactions for the top 60 DAPs indicated that tolerance-specific DAPs had relatively independent protein interaction networks in response to an anoxic environment compared with common response DAPs.The results of physiological indicators showed thatα-amylase and superoxide dismutase activities of R42 were significantly increased under anoxic conditions compared with aerobic conditions.Multiple lines of evidence from western blot,physiological analysis and quantitatDirect seeding of rice has become popular in recent years due to its low cost and convenience,however,hypoxic conditions can limit seedling establishment.In the present study,weedy rice WR04-6 with high germination ability in anaerobic conditions was used as the gene donor and successfully improved the seedling establishment rate of rice cultivar Qishanzhan(QSZ)based on selection of a new rice line R42 from the recombinant inbred line(RIL)population.R42 inherited the had high anaerobic germination(AG)ability,which was used for the isobaric tags for relative and absolute quantitation(iTRAQ)based comparative proteomic studies with QSZ to further explore the molecular mechanism of AG.A total of 719 differentially abundant proteins(DAPs)shared by R42 and QSZ responded to AG and were thus defined as common response DAPs.A total of 300 DAPs that responded to AG were only identified from R42,which were defined as tolerance-specific DAPs.The common response and tolerance-specific DAPs had similar biochemical reaction processes and metabolic pathways in response to anoxic stress,however they involved different proteins.The 300 tolerance-specific DAPs were involved in amino acid metabolism,starch and sucrose metabolism,TCA cycle pathways,ethylene synthesis pathway,cell wall-associated proteins and activity of active oxygen scavenging enzyme.The in silico protein-protein interactions for the top 60 DAPs indicated that tolerance-specific DAPs had relatively independent protein interaction networks in response to an anoxic environment compared with common response DAPs.The results of physiological indicators showed thatα-amylase and SOD activities of R42 were significantly increased under anoxic conditions compared with aerobic conditions.Multiple lines of evidence from western blot,physiological analyses and real-time PCR jointly supported the reliability of proteomics data.In summary,our findings deepened the understanding of the molecular mechanism for the rice response to AG.ive real-time PCR jointly supported the reliability of proteomics data.In summary,our findings deepened the understanding of the molecular mechanism for the rice response to AG. | Zhang Guangchen Liu Zimeng Liu Yoxihong Kuya Noriyuki HuAYuchen Shi Hongru Zhao Weilin Han Yuqing Yamamoto Toshio Chen Wenfu Sun Jian | 2021 | Rice science2021，28，4： | 2 |
| 6 | A Mean-Field Linear-Quadratic Stochastic Stackelberg Differential Game with one Leader and Two Followers显示文摘This paper is concerned with a linear-quadrati stochastic Stackelberg differential game with one leader and two followers,where the game system is governed by a mean-field stochastic differential equatio.By maximum principle and verification theorem,the open-loop Stackelberg solution is expressed as a feedback form of the state and its mean with the help of three systems of Riccati equations. | WANG Guangchen ZHANG Susu | 2020 | Journal of Systems Science & Complexity2020，33，5： | 1 |
| 7 | MicroRNA-708 inhibits the proliferation and chemoresistance of pancreatic cancer cells显示文摘Pancreatic cancer is one of the most aggressive malignancies with poor prognosis and high mortality.Recent studies showed that microRNAs are dysregulated and involved in the initiation and progression of pancreatic cancer.In this study,we found that miR-708 was significantly downregulated in pancreatic cancer tissues and cell lines.Lentivirus-mediated overexpression of miR-708 could significantly inhibit the proliferation and invasion,while enhanced chemosensitivity to gemcitabine in both Panc-1 and SW1990 cells.Luciferase reporter assay showed that miR-708 bound the 3’-untranslated region of survivin and suppressed the expression of survivin in pancreatic cancer cells.In pancreatic cancer tissues,survivin protein was highly expressed and negatively correlated with miR-708 expression.Furthermore,the restoration of survivin expression could partially antagonize proliferation inhibition and apoptosis induction by miR-708 in pancreatic cancer cells.The Panc-1 cells with overexpression of miR-708 also showed decreased proliferation capability in nude mouse model compared with parental cells.In conclusion,our results suggest that miR-708 inhibits pancreatic cancer and could be a novel potential candidate to treat pancreatic cancer. | Wensong LIU Yunjie LU Dong ZHANG Longqing SHI Guangchen ZU Haijiao YAN Donglin SUN | 2020 | BIOCELL2020，44，1： | 1 |
| 8 | Distributed fixed-time attitude coordinated control for multiple spacecraft with actuator saturation显示文摘This paper investigates the distributed fixed-time attitude coordinated control problem for multiple spacecraft subject to actuator saturation under the directed topology. First, a distributed fixed-time observer is presented for each follower spacecraft to estimate the leader spacecraft’s states. Compared with the commonly used fixed-time observer, the settling time of the proposed fixed-time observer can be easily adjusted by some free design parameters. Next, a distributed fixed-time control scheme is derived by using the estimates of the leader spacecraft’s states and the adding a power integrator technique. When considering actuator saturation, an auxiliary system is utilized to compensate the saturation. Further, a rigorous theoretical proof is provided to show that the practical fixed-time stability of the closed-loop system is ensured. Finally, simulation results illustrate the benefits and effectiveness of the developed control scheme. | Han GAO Yuanqing XIA Xiaopu ZHANG Guangchen ZHANG | 2022 | Chinese Journal of Aeronautics2022，35，4： | 1 |
| 9 | PITX2 in pancreatic stellate cells promotes EMT in pancreatic cancer cells via the Wnt/β-catenin pathway显示文摘Since the prognosis of patients with pancreatic cancer is very poor and there is a lack of treatment methods,this study is performed to investigate the function of PITX2 in pancreatic stellate cells(PSCs)in the progression of pancreatic cancer.Scientific hypotheses are proposed according to bioinformatics analysis and tissue microarray analysis.Stable knockdown of PITX2 in PSCs is achieved through lentiviral infection.The relative expressions of PITX2,α-SMA,vimentin,CTNNB1,AXIN1 and LEF1 are measured in wild-type PSCs and PITX2-knockdown PSCs.Proliferative capacity is measured by EdU assay.After coculture with PSCs,the proliferation,invasion and migration capacity of pancreatic cancer cells are tested.EMT and Wnt/β-catenin downstream genes of pancreatic cancer cells are investigated to reveal the potential mechanism.Bioinformatics analysis reveals that the PITX2 gene is highly expressed in stromal cells in pancreatic cancer and is correlated with squamous-type PDAC.Analysis of PDAC tissue microarray further demonstrates that high PITX2 level in stromal cells is correlated with poor prognosis in PDAC.After stable knockdown of PITX2 in PSCs,the relative protein levels ofα-SMA,vimentin,CTNNB1,AXIN1 and LEF1 are decreased,and the proliferative capacity of PSCs is also decreased.After coculture with PSCs,in which PITX2 expression is downregulated,the proliferation,invasion and migration capacities of pancreatic cancer cells are inhibited.Thus,our results show that PITX2-silenced PSCs inhibit the growth,migration and invasion of pancreatic cancer cells via reduced EMT and Wnt/β-catenin signaling. | Di Wu Weibo Chen Yang Yang Yi Qin Guangchen Zu Yue Zhang Yong An Donglin Sun Xiaowu Xu Xuemin Chen | 2023 | Acta Biochimica et Biophysica Sinica2023，55，9： | 1 |
| 10 | A systematic review on the safety of Psoraleae Fructus:potential risks,toxic characteristics,underlying mechanisms and detoxification methods显示文摘Psoraleae Fructus(PF)is an important traditional herbal medicine with a long history of clinical application.It is widely used to treat various diseases,such as osteoporosis,leucoderma and diarrhea.As a traditional nontoxic herb,it has aroused worldwide concern about the potential risks due to increasing adverse reaction events.This article reviews the botany,ancient records of medical uses,adverse reactions,toxicological research advance and detoxification methods of PF.According to clinical studies,liver injury is the most predominant in PF-related adverse reactions.The underlying mechanisms include bile acid metabolism and transport disorders,oxidative stress,mitochondrial damage,inhibition of liver cell regeneration and inflammatory reactions.Furthermore,the potential toxins of PF are summarized.Traditional methods of processing and compatibility will provide reference for reducing the toxicity of PF,which requires further research.In sum,this work systematically summarizes the reserach progress on the safety of PF,which will provide comprehensive insights into the toxicity of PF and facilitate its safe use and future development. | SHI Zhuo GAO Jing PAN Jinchao ZHANG Zuqi ZHANG Guangchen WANG Yuguang GAO Yue | 2022 | Chinese Journal of Natural Medicines2022，20，11： | 1 |
| 11 | A partial information linear-quadratic optimal control problem of backward stochastic differential equation with its applications显示文摘In this paper,we investigate a kind of partial information linear-quadratic optimal control problem driven by a backward stochastic differential equation,where the state equation and the cost functional contain diffusion terms.Using maximum principle,we derive the corresponding Hamiltonian system,which is a conditional mean-field forward-backward stochastic differential equation.By the backward separation approach and the filtering technique,we get two Riccati equations,and a backward and a forward optimal filtering equations.Then a feedback form of optimal control is obtained.We also extend the control problem to the case of mean-field backward stochastic differential equation under partial information.A corresponding feedback form of optimal control is also obtained. | Pengyan HUANG Guangchen WANG Huanjun ZHANG | 2020 | Science China(Information Sciences)2020，63，9： | 1 |
| 12 | Energy Efficiency Maximization in Mobile Edge Computing Networks via IRS assisted UAV Communications显示文摘In this paper,we investigate the energy efficiency maximization for mobile edge computing(MEC)in intelligent reflecting surface(IRS)assisted unmanned aerial vehicle(UAV)communications.In particular,UAVcan collect the computing tasks of the terrestrial users and transmit the results back to them after computing.We jointly optimize the users’transmitted beamforming and uploading ratios,the phase shift matrix of IRS,and the UAV trajectory to improve the energy efficiency.The formulated optimization problem is highly non-convex and difficult to be solved directly.Therefore,we decompose the original problem into three sub-problems.We first propose the successive convex approximation(SCA)based method to design the beamforming of the users and the phase shift matrix of IRS,and apply the Lagrange dual method to obtain a closed-form expression of the uploading ratios.For the trajectory optimization,we propose a block coordinate descent(BCD)based method to obtain a local optimal solution.Finally,we propose the alternating optimization(AO)based overall algorithmand analyzed its complexity to be equivalent or lower than existing algorithms.Simulation results show the superiority of the proposedmethod compared with existing schemes in energy efficiency. | Ying Zhang Weiming Niu Supu Xiu Guangchen Mu | 2024 | Computer Modeling in Engineering & Sciences2024，138，2： | 0 |
| 13 | Active Kriging-Based Adaptive Importance Sampling for Reliability and Sensitivity Analyses of Stator Blade Regulator显示文摘The reliability and sensitivity analyses of stator blade regulator usually involve complex characteristics like highnonlinearity,multi-failure regions,and small failure probability,which brings in unacceptable computing efficiency and accuracy of the current analysismethods.In this case,by fitting the implicit limit state function(LSF)with active Kriging(AK)model and reducing candidate sample poolwith adaptive importance sampling(AIS),a novel AK-AIS method is proposed.Herein,theAKmodel andMarkov chainMonte Carlo(MCMC)are first established to identify the most probable failure region(s)(MPFRs),and the adaptive kernel density estimation(AKDE)importance sampling function is constructed to select the candidate samples.With the best samples sequentially attained in the reduced candidate samples and employed to update the Kriging-fitted LSF,the failure probability and sensitivity indices are acquired at a lower cost.The proposed method is verified by twomulti-failure numerical examples,and then applied to the reliability and sensitivity analyses of a typical stator blade regulator.Withmethods comparison,the proposed AK-AIS is proven to hold the computing advantages on accuracy and efficiency in complex reliability and sensitivity analysis problems. | Hong Zhang Lukai Song Guangchen Bai | 2023 | Computer Modeling in Engineering & Sciences2023，，3： | 0 |
| 14 | A positive feedback loop of ARF6 activates ERK1/2 signaling pathway via DUSP6 silencing to promote pancreatic cancer progression显示文摘ERK1/2 are essential proteins mediating mitogen-activated protein kinase signaling downstream of RAS in pancreatic adenocarcinoma(PDAC).Our previous study reveals that ARF6 plays a positive regulatory role in ERK1/2 pathway in a feedback loop manner.A significant part of the literature on ARF6 has emphasized its oncogenic effect as an essential downstream molecule of ERK1/2,and no research has been done on the regulation mechanisms of the feedback loop between ARF6 and the ERK1/2 signaling pathway.In the present study,we explore the gene network downstream of ARF6 and find that DUSP6 may be the critical signal molecule in the positive feedback loop between ARF6 and ERK1/2.Specifically,to elucidate the negative correlations between ARF6 and DUSP6 in pancreatic cancer,we examine their expressions in pancreatic cancer tissues by immunohistochemical staining.Then the impact of DUSP6 on the proliferation and apoptosis of PDAC cells are investigated by gain-of-function and loss-of-function approaches.Mechanism explorations uncover that ARF6 suppresses the expression of DUSP6,which is responsible for the dephosphorylation of ERK1/2.Altogether,these results indicate that DUSP6 plays a tumor-suppressive role and acts as an intermediate molecule between ARF6 and ERK1/2 in PDAC cells,thereby forming a positive feedback loop. | Bingkai Xiao Yue Zhang Zekun Lu Weibo Chen Yong An Guangchen Zu Xiaowu Xu Di Wu Hao Yang Yi Qin Xuemin Chen | 2022 | Acta Biochimica et Biophysica Sinica2022，54，10： | 0 |
| 15 | 中国空间站关键技术及在轨验证概述显示文摘Tiangong space station is a space station independently designed and developed by China.In order to build and operate the space station,it was necessary to make breakthroughs in many fields and master several key technologies,which were characterized over a long technological span and underwent difficult verifications.Therefore,in addition to ground verification,on-orbit flight tests of key technologies for the assembly,construction and operation of the space station were planned to be conducted used by the core module,taking into account the differences in the gravity environment between space and the Earth,in order to lay a foundation for the subsequent comprehensive assembly,construction and long-term on-orbit operation of the space station.In this paper,the mission characteristics of the space station are briefly introduced,along with the key technologies for the assembly and construction of the space station,and then the on-orbit verification tests are comprehensively introduced. | ZHANG Hao ZHU Guangchen | 2022 | Aerospace China2022，23，1： | 0 |
| 16 | Value iteration algorithm for continuous-time linear quadratic stochastic optimal control problems显示文摘In this study,we investigate a continuous-time infinite-horizon linear quadratic stochastic optimal control problem with multiplicative noise in control and state variables.Using the techniques of stochastic stability,exact observability,and stochastic approximation,a value iteration algorithm is developed to solve the corresponding generalized algebraic Riccati equation.Unlike the existing policy iteration algorithm,this algorithm does not rely on an initial stabilizing control.Further,this algorithm can also be used to compute policy evaluation steps that arise in the policy iteration algorithm.Herein,a simulation example is provided to validate the obtained results. | Guangchen WANG Heng ZHANG | 2024 | Science China(Information Sciences)2024，67，2： | 0 |
| 17 | Optimal Operation Strategy of Electricity-Hydrogen Regional Energy System under Carbon-Electricity Market Trading显示文摘Given the“double carbon”objective and the drive toward low-carbon power,investigating the integration and interaction within the carbon-electricity market can enhance renewable energy utilization and facilitate energy conservation and emission reduction endeavors.However,further research is necessary to explore operational optimization methods for establishing a regional energy system using Power-to-Hydrogen(P2H)technology,focusing on participating in combined carbon-electricity market transactions.This study introduces an innovative Electro-Hydrogen Regional Energy System(EHRES)in this context.This system integrates renewable energy sources,a P2H system,cogeneration units,and energy storage devices.The core purpose of this integration is to optimize renewable energy utilization and minimize carbon emissions.This study aims to formulate an optimal operational strategy for EHRES,enabling its dynamic engagement in carbon-electricity market transactions.The initial phase entails establishing the technological framework of the electricity-hydrogen coupling system integrated with P2H.Subsequently,an analysis is conducted to examine the operational mode of EHRES as it participates in carbon-electricity market transactions.Additionally,the system scheduling model includes a stepped carbon trading price mechanism,considering the combined heat and power generation characteristics of the Hydrogen Fuel Cell(HFC).This facilitates the establishment of an optimal operational model for EHRES,aiming to minimize the overall operating cost.The simulation example illustrates that the coordinated operation of EHRES in carbon-electricity market transactions holds the potential to improve renewable energy utilization and reduce the overall system cost.This result carries significant implications for attaining advantages in both low-carbon and economic aspects. | Jingyu Li Mushui Wang Zhaoyuan Wu Guizhen Tian Na Zhang Guangchen Liu | 2024 | Energy Engineering2024，121，3： | 0 |
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