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| 1 | Selective laser melting of NiTi alloy with superior tensile property and shape memory effect显示文摘It is a challenge to develop complex-shaped Ni Ti shape memory alloy parts by traditional processing methods, due to the poor machinability of Ni Ti alloy. It is reported that selective laser melting(SLM) of additive manufacturing could overcome this problem. However, the reported SLM-produced Ni Ti exhibits poor tensile ductility due to the inner defects and adverse unidirectional columnar grains from SLM process. In this work, the defect-less SLM-Ni Ti with nondirective columnar grains was fabricated by optimizing the intraformational laser scanning length and interformational laser scanning direction. The obtained lath-shaped SLM-Ni Ti sample exhibits tensile strain of 15.6%, more than twice of the reported maximum result(7%). Besides, the SLM-Ni Ti part with complex geometry displays a shape memory recovery of 99% under compressive deformation of 50%. | Zhiwei Xiong Zhonghan Li Zhen Sun Shijie Hao Ying Yang Meng Li Changhui Song Ping Qiu Lishan Cui | 2019 | Journal of Materials Science & Technology2019，35，10： | 15 |
| 2 | Preparation of two kinds of superparamagnetic carriers-supported cis-platinum complexes and the compari-son of their characteristics显示文摘The purpose of the research is to ex- plore the effect of different surface modifiers in preparation of magnetic carriers-supported cis-plat- inum (CDDP) complex and their characteristics. So- dium alginate (SA) and N-oleoylsarcosine (NOSARK) were used respectively as linkers between CDDP and magnetic nanometer particles (MNP), and carri- ers-supported CDDP complex of carboxymethyl dex- tran (CM-dex) was used as the control. The physical and chemical characteristics of CDDP-MNP were measured by transmission electron microscope, photon correlation spectrum (PCS), spectrophotome- ter, etc. The advantages and disadvantages of the two linkers were analyzed through comparing the stability and quantity of reversibly bound CDDP. The cis-platinum magnetic nanometer particles were found to have the shape of approximately uniformly pellets under transmission electron microscope. The distribution of PCS diameter was 43―52 nm and the diameter of magnetic nucleus of CDDP- MNP com- plex was about 8.8±1.3 nm. The drug- loading ca- pacity of SA is larger than that of NOSARK, and similar to that of CM-dex. The SA-modified CDDP-MNP solution remained stable after being kept at 4℃ for 40 d. SA is superior to NOSARK as a magnetic nanoparticles surface modifier. Natural SA can supersede CM-dex to serve as linker between CDDP and MNP. In practical application, we should take both the maximal reversible CDDP-bonding capacity and CDDP utilization rate into consideration. | XIE Minqiang CHEN Shuaijun XU Xueqing LI Zhonghan SHEN Hui XU Jiarui | 2006 | Chinese Science Bulletin2006，51，2： | 11 |
| 3 | IL-25 stimulates M2 macrophage polarization and thereby promotes mitochondrial respiratory capacity and lipolysis in adipose tissues against obesity显示文摘Obesity and associated metabolic diseases are characterized by a chronic low-grade inflammatory state with the infiltration of many inflammatory cells,especially macrophages.Immune molecules,including some cytokines,have a close relationship with metabolism.Interleukin(IL)-25 is a member of the IL-17 cytokine family that can regulate macrophages and alleviate some metabolic dysfunction;however,its role and mechanisms in lipid metabolism remain to be extensively clarified.Human serum and liver biopsy specimens,high-fat diet-induced obesity mice and DB/DB(Lepr−/−)animal models were used to examine IL-25 expression in obesity and nonalcoholic fatty liver diseases(NAFLD).To observe the role of IL-25 in lipid metabolism,model mice were administered with IL-25 or adoptively transferred with IL-25-educated macrophages in vivo,whereas bone marrow-derived macrophages,the macrophage cell line RAW264.7 and adipocytes differentiated from 3T3-L1 were used in vitro.IL-25 was decreased in NAFLD patients and obese mice.In addition,IL-25 reduced body weight gain and lipid accumulation,enhanced lipid uptake by macrophages and increased the expression of lipolysis andβ-oxidation enzymes via alternatively activating macrophages.IL-25 also promoted lipolysis and suppressed lipogenesis in adipocytes co-cultured with the IL-25-educated macrophages.Furthermore,IL-25 improved the mitochondrial respiratory capacity and oxygen consumption rate of macrophages and produced more NAD+/NADH and ATP.In conclusion,IL-25 can stimulate M2 macrophage polarization and thereby promote lipolysis and mitochondrial respiratory capacity,highlighting the potential for IL-25 to be used as a therapeutic agent against obesity and associated metabolic syndromes. | Juan Feng Lingyi Li Zhiying Ou Qiao Li Baoyong Gong Zhenxian Zhao Weiwei Qi Ti Zhou Jun Zhong Weibin Cai Xia Yang Aiping Zhao Guoquan Gao Zhonghan Yang | 2018 | Cellular & Molecular Immunology2018，15，5： | 10 |
| 4 | The ACTIVE study protocol:apatinib or placebo plus gefitinib as first-line treatment for patients with EGFR-mutant advanced non-small cell lung cancer(CTONG1706)显示文摘Background:Gefitinib,as the first epidermal growth factor receptor tyrosine kinase inhibitors(EGFR-TKI)approved for the treatment of advanced non-small cell lung cancer(NSCLC),has been proved to significantly improve the progression-free survival(PFS)in the first-line setting but suffers from resistance 7-10 months after treatment initia-tion.Apatinib(YN968D1),a potent vascular endothelial growth factor receptor(VEGFR)2-TKI,specifically binds to VEGFR2 and leads to anti-angiogenetic and anti-neoplastic effect.Concurrent inhibition of VEGFR and EGFR path-ways represents a rational approach to improve treatment responses and delay the onset of treatment resistance in EGFR-mutant NSCLC.This ACTIVE study aims to assess the combination of apatinib and gefitinib as a new treatment approach for EGFR-mutant NSCLC as a first-line setting.Methods:This multicenter,randomized,double-blind,placebo-controlled phase III study(NCT02824458)has been designed to assess the efficacy and safety of apatinib or placebo combined with gefitinib as a first-line treatment for patients with EGFR-mutant advanced NSCLC.A total of 310 patients with EGFR-mutation(19del or 21L858R),pathological stage IIIB to IV non-squamous NSCLC were to be enrolled.The primary endpoint is investigator assessment of PFS,and the secondary endpoints include independent radiological central(IRC)-confirmed PFS,overall survival(OS),objective response rate(ORR),disease control rate(DCR),time to progressive disease(TTPD),duration of response(DoR),quality of life(QoL)and safety.The patients are randomized in a 1:1 ratio to receive gefitinib(250 mg,p.o.q.d.)plus apatinib(500 mg,p.o.q.d.)or gefitinib plus placebo,given until disease progression or intolerable adverse events.Exploratory biomarker analysis will be performed.This study is being conducted across China and comprises of 30 participating centers.Enrollment commenced in August 2017 and finished in December 2018,most of the patients are in the follow-up period.Anticipated outcomes and significance:The present study will be the first to evaluate the efficacy and safety profile of the combination of apatinib plus gefitinib as a first-line therapy for patients with EGFR-positive advanced non-squamous NSCLC.Importantly,this trial will provide comprehensive evidence on the treatment of EGFR-TKIs combined with antiangiogenic therapy. | Zhonghan Zhang Fan Luo Yang Zhang Yuxiang Ma Shaodong Hong Yunpeng Yang Wenfeng Fang Yan Huang Li Zhang Hongyun Zhao | 2019 | Cancer Communications2019，39，1： | 5 |
| 5 | Effects of electroacupuncture at Zusanli (ST 36) on neurons in the colonic myenteric plexus in rats with irritable bowel syndrome with constipation显示文摘We studied the effects of electroacupuncture at Zusanli (ST 36) on neurons in the colonic myenteric plexus and on defecation in rats with irritable bowel syndrome with constipation (IBS-C). We also used intragastric administration of pinaverium bromide as a positive control treatment to reveal the pathway mediating the onset of IBS-C. Both electroacupuncture and pinaverium bromide greatly improved defecation in rats with IBS-C. Immunohistochemical staining of the enteric nervous system neuronal marker protein gene product 9.5 in the colonic myenteric plexus showed that electroacupuncture by itself, or in combination with pinaverium bromide, increased the number of neurons and the staining intensity of protein gene product 9.5 in the colonic myenteric plexus. We conclude that visceral hypersensitivity is likely to be a primary cause of constipation in IBS-C rats. | Liting Zhu Zhonghan Li Bin Xu Chen Xia Jie Cheng Xiaoren Xiang Yi Zhu | 2011 | Neural Regeneration Research2011，6，33： | 3 |
| 6 | Exome sequencing identifies rare mutations of LDLR and QTRT1 conferring risk for early-onset coronary artery disease in Chinese显示文摘Despite the advances made over the past decades,the known loci for coronary artery disease(CAD)still only explain<20%of the genetic variation in risk[1,2].The known loci with the strongest effects usually confer a 20%-37%increased CAD risk and the most loci modulate risk by≤10%[1].While most of the current data are from European populations,the use of trans-ethnic analyses could be helpful to identify additional loci.Genetic inheritance may impose a high burden on early-onset coronary artery disease(EOCAD). | Kang Yao Yuxiang Dai Juan Shen Yi Wang Huanjie Yang Runda Wu Qijun Liao Hongyi Wu Xiaodong Fang Shalaimaiti Shali Lili Xu Meng Hao Chenhao Lin Zhonghan Sun Yilian Liu Mengxin Li Zhen Wang Qiang Gao Shuning Zhang Chenguang Li Wei Gao Lei Ge Yunzeng Zou Aijun Sun Juying Qian Li Jin Shangyu Hong Yan Zheng Junbo Ge | 2022 | National Science Review2022，9，8： | 1 |
| 7 | Selective laser melted high Ni content TiNi alloy with superior superelasticity and hardwearing显示文摘TiNi alloys with high content Ni(52-55 at.%)are perfectly suitable for preparing wear-and corrosionresistant parts that service on the space station,spacecraft,and submarine,because of their superior superelasticity,high strength,and hardwearing.However,the fabrication of complicated Ni-rich TiNi parts by the traditional machining method often faces problems of poor precision,low efficiency,and high cost.In this work,we succeed in preparing an excellent Ti_(47)Ni_(53) alloy by selective laser melting(SLM),and thus,open a new way for the efficient and precise formation of complicated Ni-rich TiNi parts with superelasticity and hardwearing.An optimized processing window for compact parts without defects is reported.The elaborately fabricated Ti_(47)Ni_(53) alloy exhibited a breaking strain of 11%,a breaking stress of 2.0 GPa,a superelastic strain of 9%,and a better hardwearing than that of casting and quenched Ti_(47)Ni_(53) alloy.Besides,the microstructure,phase transformation,and deformation,as well as their influence mechanisms are investigated by in situ transmission electron microscope(TEM)and high-energy X-ray diffraction(HE-XRD).The results obtained are of significance for both fundamental research and technological applications of SLM-fabricated high Ni content TiNi alloys. | Hui Shen Qingquan Zhang Ying Yang Yang Ren Yanbao Guo Yafeng Yang Zhonghan Li Zhiwei Xiong Xiangguang Kong Zhihui Zhang Fangmin Guo Lishan Cui Shijie Hao | 2022 | Journal of Materials Science & Technology2022，，21： | 1 |
| 8 | Diagnosis of sewer pipe defects on image recognition of multi-features and support vector machine in a southern Chinese city显示文摘Closed circuit television(CCTV)systems are widely used to inspect sewer pipe conditions.During the diagnosis process,the manual diagnosis of defects is time consuming,labor intensive and error prone.To assist inspectors in diagnosing sewer pipe defects on CCTV inspection images,this paper presents an image recognition algorithm that applies features extraction and machine learning approaches.An algorithm of image recognition techniques,including Hu invariant moment,texture features,lateral Fourier transform and Daubechies(DBn)wavelet transform,was used to describe the features of defects,and support vector machines were used to classify sewer pipe defects.According to the inspection results,seven defects were defined;the diagnostic system was applied to a sewer pipe system in a southern city of China,and 28,760 m of sewer pipes were inspected.The results revealed that the classification accuracies of the different defects ranged from 51.6% to 99.3%.The overall accuracy reached 84.1%.The diagnosing accuracy depended on the number of the training samples,and four fitting curves were applied to fit the data.According to this paper,the logarithmic fitting curve presents the highest coefficient of determination of 0.882,and more than 200 images need to be used for training samples to guarantee the accuracy higher than 85%. | Xiangyang Ye Jian’e Zuo Ruohan Li Yajiao Wang Lili Gan Zhonghan Yu Xiaoqing Hu | 2019 | Frontiers of Environmental Science & Engineering2019，13，2： | 1 |
| 9 | SERPINA 3 K induces apoptosis in human colorectal cancer cells via activating the F as/ F as L /caspase‐8 signaling pathway显示文摘 | Yachao Yao Lei Li Xuan Huang Xiaoqiong Gu Zumin Xu Yang Zhang Lijun Huang Shuai Li Zhiyu Dai Cen Li Ti Zhou Weibin Cai Zhonghan Yang Guoquan Gao Xia Yang | 2013 | FEBS J2013，，14： | 1 |
| 10 | Instructive cartilage regeneration modalities with advanced therapeutic implantations under abnormal conditions显示文摘The development of interdisciplinary biomedical engineering brings significant breakthroughs to the field of cartilage regeneration.However,cartilage defects are considerably more complicated in clinical conditions,especially when injuries occur at specific sites(e.g.,osteochondral tissue,growth plate,and weight-bearing area)or under inflammatory microenvironments(e.g.,osteoarthritis and rheumatoid arthritis).Therapeutic implantations,including advanced scaffolds,developed growth factors,and various cells alone or in combination currently used to treat cartilage lesions,address cartilage regeneration under abnormal conditions.This review summarizes the strategies for cartilage regeneration at particular sites and pathological microenvironment regulation and discusses the challenges and opportunities for clinical transformation. | Zhonghan Wang Hanxiang Le Yanbing Wang He Liu Zuhao Li Xiaoyu Yang Chenyu Wang Jianxun Ding Xuesi Chen | 2022 | Bioactive Materials2022，7，5： | 0 |
| 11 | An in-situ spectroscopy investigation of alkali metal interaction mechanism with the imide functional group显示文摘Organic anode materials have attracted considerable interest owing to their high tunability by adopting various active functional groups.However,the interaction mechanisms between the alkali metals and the active functional groups in host materials have been rarely studied systematically.Here,a widely used organic semiconductor of perylene-3,4,9,10-tetracarboxylic diimide(PTCDI)was selected as a model system to investigate how alkali metals interact with imide functional groups and induce changes in chemical and electronic structures of PTCDI.The interaction at the alkali/PTCDI interface was probed by in-situ X-ray photoelectron spectroscopy(XPS),ultraviolet photoelectron spectroscopy(UPS),synchrotron-based near edge X-ray absorption fine structure(NEXAFS),and corroborated by density functional theory(DFT)calculations.Our results indicate that the alkali metal replaces the hydrogen atoms in the imide group and interact with the imide nitrogen of PTCDI.Electron transfer induced gap states and downward band-bending like effects are identified on the alkali-deposited PTCDI surface.It was found that Na shows a stronger electron transfer effect than Li.Such a model study of alkali insertion/intercalation in PTCDI gives insights for the exploration of the potential host materials for alkali storage applications. | Xu Lian Zhirui Ma Zhonghan Zhang Jinlin Yang Shuo Sun Chengding Gu Yuan Liu Honghe Ding Jun Hu Xu Cao Junfa Zhu Shuzhou Li Wei Chen | 2020 | Nano Research2020，13，12： | 0 |
| 12 | N-Heterocycles Extended π-Conjugation Enables Ultrahigh Capacity,Long-Lived,and Fast-Charging Organic Cathodes for Aqueous Zinc Batteries显示文摘The aqueous zinc-organic battery is a promising candidate for large-scale energy storage.However,the rational design of advanced organic cathodes with high capacity,long lifespan,and high rate capability remains a big challenge.Herein,we propose that extending theπ-conjugation by N-heterocycles can provide more active sites,lead to insolubility,and facilitate charge transfer,thus boosting the overall electrochemical performance of organic electrodes.Based on this concept,a novel organic compound,dipyrido[3ʹ,2ʹ:5,6;2″,3″:7,8]quinoxalino[2,3-i]dipyrido[3,2-a:2ʹ,3ʹ-c]phenazine-10,21-dione(DQDPD),has been rationally designed and evaluated as the cathode for aqueous zinc batteries.Excitingly,DQDPD shows a record high capacity(509 mAh g^(−1) at 0.1 A g^(−1),corresponding to a record-breaking energy density of 348 Wh kg^(−1)),excellent cycling stability(92%capacity retention after 7500 cycles at 10 A g^(−1)),and fast-charging capability(161 mAh g^(−1) at 20 A g^(−1)).Our work offers new ideas in the molecular engineering of organic electrodes for high-performance rechargeable batteries. | Huiling Peng Jin Xiao Zhonghan Wu Lei Zhang Yaheng Geng Wenli Xin Junwei Li Zichao Yan Kai Zhang Zhiqiang Zhu | 2023 | CCS Chemistry2023，5，8： | 0 |
| 13 | Nanoparticle(NP)-mediated APOC1 silencing to inhibit MAPK/ERK and NF-κB pathway and suppress breast cancer growth and metastasis显示文摘Breast cancer is one of the most common malignant tumors with high mortality and poor prognosis in women.There is an urgent need to discover new therapeutic targets for breast cancer metastasis.Herein,we identified that Apolipoprotein C1(APOC1)was up-regulated in primary tumor of breast cancer patient that recurrence and metastasis by immunohistochemistry(IHC).Kaplan-Meier Plotter database showed that high levels of APOC1 in breast cancer patients were strongly associated with worse overall survival(OS)and relapse-free survival(RFS).Mechanistically,APOC1 silencing significantly inhibits MAPK/ERK kinase pathway and restrains the NF-κB to decrease the transcription of target genes related to growth and metastasis in vitro.Based on this regulatory mechanism,we developed these findings into potential therapeutic drugs,glutathione(GSH)responsive nanoparticles(NPs)were used for systemic APOC1 siRNA delivery,NPs(siAPOC1)silenced APOC1 expression,and subsequently resulted in positive anti-tumor effects in orthotopic and liver metastasis models in vivo.Taken together,GSH responsive NPmediated siAPOC1 delivery was proved to be effective in regulating growth and metastasis in multiple tumor models.These findings show that APOC1 could be a potential biomarker to predict the prognosis of breast cancer patients and NP-mediated APOC1 silencing could be new strategies for exploration of new treatments for breast cancer metastasis. | Shaomin Liu Fengqian Zhang Yixia Liang Guo Wu Rong Liu Xiuling Li Phei Er Saw Zhonghan Yang | 2023 | Science China(Life Sciences)2023，66，11： | 0 |
| 14 | EFFECT OF CeO_2 ON MICROSTRUCTURE AND WEAR RESISTANCE OF LASER REMELTED FeBSi COATING显示文摘The hardness and wear resistance of sprayed FeBSi coating after laser remelting weremuch improved by addition of 8 wt-% CeO2.Microstructural observation on theFeBSi+CeO2 coating revealed that the formation of martensite occurs,as well as therefined grains and the more eutectic and compounds with regular morphology are dis-tributed.While the FeBSi coating free from CeO2 is a sharp constrast in microstructure. | WU Yigui LI Yan YU Zhonghan Luoyang Institute of Technology,Luoyang,ChinaLIU Jiajun WANG Yu Tsinghua University,Beijing,China Laboratory of Materials,Luoyang Institute of Technology,Luoyang 471039,China | 1993 | Acta Metallurgica Sinica(English Letters)1993，6，11： | 0 |
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