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| 1 | The Genome of Artemisia annua Provides Insight into the Evolution of Asteraceae Family and Artemisinin Biosynthesis显示文摘Artemisia annua,通常已知的同样香甜的苦恼或 Qinghao,是到中国的一个灌木土著人并且长被用于药用的目的。A。annua 现在作为有势力抗疟药混合物的唯一的生来的来源全球性被栽培, artemisinin。这里,我们报导 A 的 1.74-gigabase 染色体的一个高质量的草稿集会。annua,高度异质接合,富于重复定序,并且包含 63 ? 226 编码蛋白质的基因,在定序的植物种类之中的最大的数字之一。我们发现了那,作为在 Asteraceae 的一些定序的染色体之一, A。annua 染色体包含对这大被子植物 clade 特定的很多基因。尤其是,扩大和编码涉及萜烯生合成的酶的基因的功能的多样化与 artemisinin biosynthetic 小径的进化一致。我们进一步由介绍那 A 的 transcriptome 揭示了。annua 发展了复杂 transcriptional 规章的网络位于 \O 下面 artemisinin 生合成。把转基因的 A 基于我们产生了的全面 genomic 和 transcriptomic 分析。artemisinin 高级的生产的 annua 线,它现在为大规模生产准备好了并且将从而帮助遇见增加 artemisinin 的全球需求的挑战。 | Qian Shen Lida Zhang Zhihua Liao Shengyue Wang Tingxiang Yan Pu Shi Meng Liu Xueqing Fu Qifang Pan Yuliang Wang Zongyou Lv Xu Lu Fangyuan Zhang Weimin Jiang Yanan Ma Minghui Chen Xiaolong Hao Ling Li Yueli Tang Gang Lv Yan Zhou Xiaofen Sun Peter E. Brodelius Jocelyn K.C. Rose Kexuan Tang | 2018 | Molecular Plant2018，11，6： | 47 |
| 2 | Expert Consensus on the Care and Management of Patients with Cognitive Impairment in China显示文摘The cognitive disease consensus was prepared by panels of health and public representatives based on actual clinical practice in Geriatric Departments in Chinese hospitals and a systematic literature review. This consensus reflects the medical knowledge accumulated by those experts and provides information about professional medical care and advice.A multidisciplinary panel of specialists(neurologists,psychiatrists, and nursing specialists) reports an expert consensus on the medical knowledge accumulated from those experts and provides information about professional medical care and advice. The recommendations focus on the care and management of older adults with mild cognitive impairment,the objectives and methods of maintaining cognition and training, the assessments and measures of daily care for patients at different stages of dementia, the assessments and coping strategies for the behavioral and psychological symptoms of dementia, principles and suggestions for an appropriate living environment, arrangements for recreational activities, the care and management of patients with endstage dementia, and suggestions for addressing stress in caregivers. | 无 Yuliang Han Jianjun Jia Xia Li Yang Lv Xuan Sun Shanshan Wang Yongjun Wang Zhiwen Wang Jintao Zhang Jiong Zhou Yuying Zhou | 2020 | Neuroscience Bulletin2020，36，3： | 7 |
| 3 | Restless legs syndrome following the use of ziprasidone: a case report显示文摘Restless legs syndrome(RLS)is a common sleep-related movement disorder characterised by an uncomfortable urge to move the legs that occurs during periods of inactivity.Although there have been many case reports on antipsychotic-induced RLS,ziprasidone has never been reported as a cause of RLS.We present a case of a female patient with schizophrenia who presented with symptoms of RLS following the administration of high doses of ziprasidone added to quetiapine and valproate.The patient’s symptoms of RLS occurred following the administration and titration of ziprasidone to 160 mg,and were relieved upon reducing the dose to 120 mg/day.Other potential causative medications and differential diagnoses that could have caused similar symptoms were excluded.Clinicians should be aware of the potential for ziprasidone-induced RLS.Dopamine and serotonin interaction could be the mechanism underlying ziprasidone-induced RLS. | Cuizhen Zhu Ran Bi Yuliang Hu Hui Zhou Daomin Zhu Brian Isaacson Qingwei Li Yezhe Lin | 2020 | General Psychiatry2020，33，2： | 3 |
| 4 | Inhibition of botulinum toxin's association with rat brain synaptosomes by toosendanin,an antibotulismic triterpenoid显示文摘BACKGROUND: Toosendanin (TSN), a triterpenoid derivative extracted from the bark of Melia toosendanin Sieb et Zucc, has been demonstrated to be an effective drug for treatment of experimental botulism. OBJECTIVE: To explore its antibotulismic mechanism by observing the effect of toosendanin on association of botulinum toxin (BoTx) with rat brain synaptosomes under different conditions. DESIGN: A randomized controlled experiment. SETTING: Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences. MATERIALS: Sprague-Dawley rats, weighing (220±12) g, were involved. TSN was a sample recrystallized in ethanol with a purity > 98%. BoTx/A and BoTx/C of 500 ku (1.8×107 mouse LD50 /mg) were purchased from Wako (Japan), Horse antitoxins to BoTx/A and /C (primary antibodies) were purchased from Lanzhou Institute of Biological Products (China). METHODS: Major experiments were finished between March 2005 and October 2005 in key laboratory of neurobiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences. ① Preparation of synaptosome of rats: one aliquot of synaptosome was pre-incubated with TSN (17 μmol/L) for 20 minutes at 4 ℃ or 37 ℃ (another aliquot of synaptosome which was untouched was used as control). Then, BoTx was respectively added for another 20-minute incubation. ② A homochronous experiment was still performed at 37 ℃. Differently, high level of K+ was used to stimulate synaptosome for 25 minutes. Two aliquots of synaptosomes with or without TSN (17 μmol/L)were preincubated for 15 minutes. Then, 30 mmol/L KCl was separately added in two aliquots, 5 minutes later, 13 nmol/L BoTx/C was separately added followed by 20-minute incubation. ③The effect of TSN on BoTx binding was observed by Western blot and synchronization method. ④ t test was used for comparing the difference of measurement data. MAIN OUTCOME MEASURES: The gray value of BoTx bands from western blot was used to estimate the bound amount of BoTx. RESULTS: ① Preincubation of synaptosomes with TSN (17 μmol/L) at 4 ℃ decreased the association of BoTx type A (BoTx/A) by (11.4±8.7) % (P < 0.05, n =8) and that of BoTx type C (BoTx/C) by (9.2±2.8)% (P < 0.05, n =8). ② When incubation temperature was set at 37 ℃, preincubation of synaptosomes with TSN (17 μmol/L) decreased the association of BoTx/C by (18.0 ± 6.7)% (n =5, vs. the control without TSN at 37 ℃, P < 0.05), but there was no significant change observed when decreasing TSN to a concentration of 0.17 μmol/L. ③ When synaptosomes preincubated with TSN in high level of K+ at 37 ℃, the inhibition of TSN on BoTx/C association further increased to (32.6±6.1)% (n =4, vs the control without TSN at 37 ℃ with high level of K+, P < 0.05). CONCLUSION: These results indicate that TSN inhibits the binding step of BoTx intoxication, and probably its subsequent temperature- and depolarization- dependent internalization of toxin. | Jianying Zhou Yuliang Shi | 2006 | Neural Regeneration Research2006，1，6： | 3 |
| 5 | Low temperature hydrothermal synthesis and electrochemical performances of LiFePO_4 microspheres as a cathode material for lithium-ion batteries显示文摘Mesoporous LiFePO4 microspheres were simply synthesized by a low temperature(130℃),template-free hydrothermal route using low cost LiOH,Fe(NO3)3 and NH4H2PO4 as starting raw materials.These microspheres are composed of densely aggregated LiFePO4 nanoparticles and filled with interconnected mesochannels,which demonstrates not only a high tap density(≥1.4 g cm-3),a high capacity of 150 mAh g-1(~90% of its theoretical capacity) at 0.5 C rate,but also a ≥ 80% utilization of its theoretical capacity at a high rate of 1 C.In addition,the hydrothermal synthesis developed in this work is simple and cost-effective,it may provide a new route for production of the LiFePO4 material in battery applications. | ZHOU Min QIAN JiangFeng CAO YuLiang YANG HanXi | 2012 | Chinese Science Bulletin2012，57，32： | 2 |
| 6 | Application of three-phase foam to fight an extraordinarily serious coal mine fire显示文摘 | Fubao Zhou Wanxing Ren Deming Wang Tiliang Song Xiang Li Yuliang Zhang | 2005 | International Journal of Coal Geology2005，，1： | 2 |
| 7 | A High Precision Comprehensive Evaluation Method for Flood Disaster Loss Based on Improved Genetic Programming显示文摘Precise comprehensive evaluation of flood disaster loss is significant for the prevention and mitigation of flood disasters. Here, one of the difficulties involved is how to establish a model capable of describing the complex relation between the input and output data of the system of flood disaster loss. Genetic programming (GP) solves problems by using ideas from genetic algorithm and generates computer programs automatically. In this study a new method named the evaluation of the grade of flood disaster loss (EGFD) on the basis of improved genetic programming (IGP) is presented (IGP-EGFD). The flood disaster area and the direct economic loss are taken as the evaluation indexes of flood disaster loss. Obviously that the larger the evaluation index value, the larger the corresponding value of the grade of flood disaster loss is. Consequently the IGP code is designed to make the value of the grade of flood disaster be an increasing function of the index value. The result of the application of the IGP-EGFD model to Henan Province shows that a good function expression can be obtained within a bigger searched function space; and the model is of high precision and considerable practical significance. Thus, IGP-EGFD can be widely used in automatic modeling and other evaluation systems. | ZHOU Yuliang LU Guihua JIN Juliang TONG Fang ZHOU Ping | 2006 | Journal of Ocean University of China2006，5，4： | 2 |
| 8 | An Improved Markov Chain Model Based on Autocorrelation and Entropy Techniques and Its Application to State Prediction of Water Resources显示文摘According to the relationships among state transition probability matrixes with different step lengths, an improved Markov chain model based on autocorrelation and entropy techniques was introduced. In the improved Markov chain model, the state transition probability matrixes can be adjusted. The steps of the historical state of the event, which was significantly related to the future state of the event, were determined by the autocorrelation technique, and the impact weights of the event historical state on the event future state were determined by the entropy technique. The presented model was applied to predicting annual precipitation and annual runoff states, showing that the improved model is of higher precision than those existing Markov chain models, and the determination of the state transition probability matrixes and the weights is more reasonable. The physical concepts of the improved model are distinct, and its computation process is simple and direct, thus, the presented model is sufficiently general to be applicable to the prediction problems in hydrology and water resources. | ZHOU Ping ZHOU Yuliang JIN Juliang LIU Li WANG Zongzhi CHENG Liang ZHANG Libing | 2011 | Chinese Geographical Science2011，21，2： | 2 |
| 9 | Efficacy,safety and immunogenicity of hexavalent rotavirus vaccine in Chinese infants显示文摘A randomized,double-blind,placebo-controlled multicenter trial was conducted in healthy Chinese infants to assess the efficacy and safety of a hexavalent live human-bovine reassortant rotavirus vaccine(HRV)against rotavirus gastroenteritis(RVGE).A total of 6400 participants aged 6-12 weeks were enrolled and randomly assigned to either HRV(n?3200)or placebo(n?3200)group.All the subjects received three oral doses of vaccine four weeks apart.The vaccine efficacy(VE)against RVGE caused by rotavirus serotypes contained in HRV was evaluated from 14 days after three doses of administration up until the end of the second rotavirus season.VE against severe RVGE,VE against RVGE hospitalization caused by serotypes contained in HRV,and VE against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were also investigated.All adverse events(AEs)were collected for 30 days after each dose.Serious AEs(SAEs)and intussusception cases were collected during the entire study.Our data showed that VE against RVGE caused by serotypes contained in HRV was 69.21%(95%CI:53.31-79.69).VE against severe RVGE and RVGE hospitalization caused by serotypes contained in HRV were 91.36%(95%CI:78.45-96.53)and 89.21%(95%CI:64.51-96.72)respectively.VE against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were 62.88%(95%CI:49.11-72.92),85.51%(95%CI:72.74-92.30)and 83.68%(95%CI:61.34-93.11).Incidences of AEs from the first dose to one month post the third dose in HRV and placebo groups were comparable.There was no significant difference in incidences of SAEs in HRV and placebo groups.This study shows that this hexavalent reassortant rotavirus vaccine is an effective,well-tolerated,and safe vaccine for Chinese infants. | Zhiwei Wu Qingliang Li Yan Liu Huakun Lv Zhaojun Mo Fangjun Li Qingchuan Yu Fei Jin Wei Chen Yong Zhang Teng Huang Xiaosong Hu Wei Xia Jiamei Gao Haisong Zhou Xuan Bai Yueyue Liu Zhenzhen Liang Zhijun Jiang Yingping Chen Jiuwei Zhang Jialiang Du Biao Yang Bo Xing Yantao Xing Ben Dong Qinghai Yang Chen Shi Tingdong Yan Bo Ruan Haiyun Shi Xingliang Fan Dongyang Feng Weigang Lv Dong Zhang Xiangchu Kong Liuyifan Zhou Dinghong Que Hong Chen Zhongbing Chen Xiang Guo Weiwei Zhou Cong Wu Qingrong Zhou Yuqing Liu Jian Qiao Ying Wang Xinguo Li Kai Duan Yuliang Zhao Gelin Xu Xiaoming Yang | 2022 | Virologica Sinica2022，37，5： | 2 |
| 10 | Analysis of regional drought characteristics based on copula in Huaibei Plain of Anhui province, China显示文摘 | Yuan Xiaochen Zhou Yuliang Wei Yiming | 2013 | Natural Hazards2013，67，2： | 1 |
| 11 | The C_(6)D_(6)detector system on the Back-n beam line of CSNS显示文摘Introduction The neutron capture cross sections are very important in the field of nuclear device design and basic physics research.Hydrogen-free liquid scintillator such as C_(6)D_(6)detectors are widely used in the neutron capture cross-sectional measurements for the low neutron sensitivity and fast time response.The Back-n white neutron source at China Spallation Neutron Source is the first spallation white neutron source in China,and it is suitable for neutron capture cross-sectional measurement.Materials and methods A C_(6)D_(6)detector system was built in the Back-n experimental station.The pulse height weighting technique was used to determine the system’s detection efficiency.The response to gamma rays of the C_(6)D_(6)detector was measured,and the energy resolution function was determined.Monte Carlo simulation with Geant4 code was carried out to get the weighting function of this C_(6)D_(6)detector system.Additionally,the systematic uncertainty of the weighting function was also determined.Conclusion According to the experimental and simulation results,this C_(6)D_(6)detector system can be used to measure neutron capture cross section. | Jie Ren Xichao Ruan Jie Bao Guangyuan Luan Wei Jiang Qi An Huaiyong Bai Ping Cao Qiping Chen Yonghao Chen Pinjing Cheng Zengqi Cui Ruirui Fan Changqing Feng Minhao Gu Fengqin Guo Changcai Han Zijie Han Guozhu He Yongcheng He Yuefeng He Hanxiong Huang Weiling Huang Xiru Huang Xiaolu Ji Xuyang Ji Haoyu Jiang Hantao Jing Ling Kang Mingtao Kang Bo Li Lun Li Qiang Li Xiao Li Yang Li Yang Li Rong Liu Shubin Liu Xingyan Liu Yinglin Ma Changjun Ning Binbin Qi Zhaohui Song Hong Sun Xiaoyang Sun Zhijia Sun Zhixin Tan Hongqing Tang Jingyu Tang Pengcheng Wang Qi Wang Taofeng Wang Yanfeng Wang Zhaohui Wang Zheng Wang Jie Wen Zhongwei Wen Qingbiao Wu Xiaoguang Wu Xuan Wu Likun Xie Yiwei Yang Han Yi Li Yu Tao Yu Yongji Yu Guohui Zhang Jing Zhang Linhao Zhang Liying Zhang Qingmin Zhang Qiwei Zhang Xianpeng Zhang Yuliang Zhang Zhiyong Zhang Yingtan Zhao Liang Zhou Zuying Zhou Danyang Zhu Kejun Zhu Peng Zhu | 2019 | Radiation Detection Technology and Methods2019，3，3： | 1 |
| 12 | P-Cadherin Promotes Liver Metastasis and Is Associated with Poor Prognosis in Colon Cancer显示文摘 | Lichao Sun Hai Hu Liang Peng Zhuan Zhou Xuan Zhao Jian Pan Lixin Sun Zhihua Yang Yuliang Ran | 2011 | The American Journal of Pathology2011，，： | 1 |
| 13 | Template-free Hydrothermal synthesis of nanoembossed mesoporous LiFeP04 microspheres for high- performance lithium-ion batteries显示文摘 | Qian Jiangfeng Zhou Min Cao Yuliang | 2010 | J Phys Chem C2010，114，8： | 1 |
| 14 | A Novel Magnetostrictive Drive Rotary Motor 显示文摘 | Jianjun Zhou Yuliang Pan Min Huang | 2007 | Solid State Phenomena (S1662-9779)2007，121，3： | 1 |
| 15 | Tumor-suppressive mir-663 gene induces mitotic catastrophe growth arrestin human gastric cancer cells显示文摘 | Jian Pan Hai Hu Zhuan Zhou Lichao Sun Liang Peng Long Yu Lixin Sun Jun Liu Zhihua Yang Yuliang Ran | 2010 | Oncology Reports2010，，1： | 1 |
| 16 | Review of Multi-regime Hybrid Vehicle Powertrain Architecture 显示文摘 | Wishart Jeffrey Zhou Yuliang Leon | 2008 | International Joumal of Electric and Hybrid Vehicles2008，1，3： | 1 |
| 17 | Morphology of single inhalable particle in the air polluted city of Shijiazhuang,China显示文摘在典型的空中, Shijiazhuang,在非加热的时期的单个 inhalable 粒子样品,加热时期,灰尘暴风雨天,和雪的天的弄脏的城市被 SEM/EDS 收集并且检测(扫描电子显微镜学和精力散 X 光检查光谱测定) 。粒子形态学被 6 形状簇描绘,它是:不规则的平方,聚结成块的,范围,絮状物,列或棍子,并且未知,由量的顺序。不规则的方形的粒子在各种样品是普通的;范围粒子是更多,并且列或棍子是在冬季样品的更少;在湿存款样品,聚结,絮状物粒子没被发现。大多数粒子的表面与分数维的边是粗糙的,它能在弄脏的大气的环境提供合适的化学反应床。新形成的钙水晶被发现表明抵销的反应的存在,解释为在 Shijiazhuang 的高 SO2 排放和低酸雨频率的原因。范围的三种表面模式光滑、半光滑、粗糙,相应于元素 Si 主导, Si-Al-dominant,并且 Fe 主导。煤烟粒子在 10 μ m 附近与平均尺寸表现为絮状物,比前者更加大报导了结果,但是包或与另外的好粒子捕获了使它的外观唯一并且潜在地提高它的毒性。新形成的钙水晶, 3 种范围表面模式,和唯一的煤烟外观在 Shijiazhuang 城市里代表单个 inhalable 粒子的形态学特征。 | WANG Zanhong ZHANG Lingzhi ZHANG Yuliang ZHAO Zhou ZHANG Sumin | 2008 | Journal of Environmental Sciences2008，20，4： | 1 |
| 18 | Improved Initial Charging Capacity of Na-poor Na0.44MnO2 via Chemical Presodiation Strategy for Low-cost Sodium-ion Batteries显示文摘Sodium-ion batteries(SIBs)are promising for grid-scale energy storage applications due to the natural abundance and low cost of sodium.Among various Na insertion cathode materials,Na0.44MnO2 has attracted the most attention because of its cost effectiveness and structural stability.However,the low initial charge capacity for Na-poor Na0.44MnO2 hinders its practical applications.Herein,we developed a facile chemical presodiated method using sodiated biphenly to transform Na-poor Na0.44MnO2 into Na-rich Na0.66MnO2.After presodiation,the initial charge capacity of Na0.44MnO2 is greatly enhanced from 56.5 mA·h/g to 115.7 mA·h/g at 0.1 C(1 C=121 mA/g)and the excellent cycling stability(the capacity retention of 94.1%over 200 cycles at 2 C)is achieved.This presodiation strategy would open a new avenue for promoting the practical applications of Na-poor cathode materials in sodium-ion batteries. | ZHOU Xi LAI Yangyang WU Xiangjiang CHEN Zhongxue ZHONG Faping Al Xinping YANG Hanxi CAO Yuliang | 2021 | Chemical Research in Chinese Universities2021，37，2： | 1 |
| 19 | Selective collection and detection of leukemia cells on a magnet-quartz crystal microbalance system using aptamer-conjugated magnetic beads显示文摘 | Pan Yuliang Guo Manli Nie Zhou | 2010 | Biosens Bioelectron2010，25，： | 1 |
| 20 | Risk analysis for drought hazard in China : a case study in Huaibei Plain 显示文摘 | Yuan Xiaochen Zhou Yuliang Jin Juliang | | Natural Hazards0，67，： | 1 |
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