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| 1 | Direct reprogramming of Sertoli cells into multipotent neural stem cells by defined factors显示文摘Multipotent 神经干细胞为房间治疗保持大诺言。到导致的 pluripotent 干细胞以及成熟神经原的成纤维细胞的 reprogramming 建议可能性没有首先建立 pluripotency,把一个严重地区分的体的房间变换成一个 multipotent 状态。这里,我们证明房间从中层导出的那 Sertoli 能直接被变换成拥有神经干细胞性质的一个 multipotent 状态。导致的神经干细胞(iNSCs ) 表示多重 NSC 特定的标记,展出类似于正常 NSC 的全球基因表示侧面,并且能够自强并且区分功能的神经原进神经胶质并且 electrophysiologically。为酷氨酸 hydroxylase (TH ) 积极的导出 iNSC 的神经原污点, γ -aminobutyric 酸,和胆碱 acetyltransferase。另外, iNSCs 能熬过并且产生跟随移植进有牙齿的回转的触处。iNSCs 的产生可以为疾病建模和再生药有重要含意。 | Chao Sheng Qinyuan Zheng Jianyu Wu Zhen Xu Libin Wang Wei Li Haijiang Zhang Xiao-Yang Zhao Lei Liu Ziwei Wang Changlong Guo Hua-Jun Wu Zhonghua Liu Liu Wang Shigang He Xiu-Jie Wang Zhiguo Chen Qi Zhou | 2012 | Cell Research2012，22，1： | 31 |
| 2 | Fully autonomous flying: from collective motion in bird flocks to unmanned aerial vehicle autonomous swarms显示文摘1 Introduction The unmanned aerial vehicle(UAV),an aircraft with no pilots on board,appeals to widespread applications in military and civil fields[1].In complex and dynamic mission environments,a single UAV | QIU HuaXin WEI Chen DOU Rui ZHOU ZiWei | 2015 | Science China Chemistry2015，58，12： | 12 |
| 3 | Laser joining of CFRTP to titanium alloy via laser surface texturing显示文摘Grid pattern was textured on Ti-6 Al-4 V alloy(TC4)substrate surface by nanosecond laser system.Laser joining of carbon fiber reinforced thermoplastic composite(CFRTP)to TC4 joints were performed,and the effect of texture grid depth was investigated.The contact angle of molten CFRTP on textured TC4 surface was measured and the tensile-shear force was tested.The fracture surface and interface morphology were observed.The results indicated that the wettability of molten CFRTP on TC4 surface improved remarkably after laser textured TC4.Shear force of CFRTP/TC4 joints was increased by 156%after laser textured TC4 surface.When the depth of grid was deeper than 100μm,contact angle increased and incomplete filling of molten CFRTP in grid occurred,the shear force thus decreased gradually.Resin-carbon fibers mixture was adhered on the fracture surface of TC4,and the variation tendency of adhesion ratio was consistent with that of shear force.TC4 matrix was exfoliated from substrate and adhered at the fracture surface of CFRTP,indicating stronger mechanical interlocking occurred at the joining interface after laser textured TC4 surface.Beside mechanical interlocking,compound layer consisted of CTi_(0.42)V_(1.58)carburization phase was also confirmed at interface,suggesting that chemical bonding also occurred at the joining interface. | Caiwang TAN Jianhui SU Ziwei FENG Yifan LIU Bo CHEN Xiaoguo SONG | 2021 | Chinese Journal of Aeronautics2021，34，5： | 11 |
| 4 | Internet of Things to network smart devices for ecosystem monitoring显示文摘Smart, real-time, low-cost, and distributed ecosystem monitoring is essential for understanding and managing rapidly changing ecosystems. However, new techniques in the big data era have rarely been introduced into operational ecosystem monitoring, particularly for fragile ecosystems in remote areas.We introduce the Internet of Things(IoT) techniques to establish a prototype ecosystem monitoring system by developing innovative smart devices and using IoT technologies for ecosystem monitoring in isolated environments. The developed smart devices include four categories: large-scale and nonintrusive instruments to measure evapotranspiration and soil moisture, in situ observing systems for CO2 and d13 C associated with soil respiration, portable and distributed devices for monitoring vegetation variables, and Bi-CMOS cameras and pressure trigger sensors for terrestrial vertebrate monitoring. These new devices outperform conventional devices and are connected to each other via wireless communication networks. The breakthroughs in the ecosystem monitoring IoT include new data loggers and longdistance wireless sensor network technology that supports the rapid transmission of data from devices to wireless networks. The applicability of this ecosystem monitoring IoT is verified in three fragile ecosystems, including a karst rocky desertification area, the National Park for Amur Tigers, and the oasis-desert ecotone in China. By integrating these devices and technologies with an ecosystem monitoring information system, a seamless data acquisition, transmission, processing, and application IoT is created. The establishment of this ecosystem monitoring IoT will serve as a new paradigm for ecosystem monitoring and therefore provide a platform for ecosystem management and decision making in the era of big data. | Xin Li Ning Zhao Rui Jin Shaomin Liu Xiaomin Sun Xuefa Wen Dongxiu Wu Yan Zhou Jianwen Guo Shiping Chen Ziwei Xu Mingguo Ma Tianming Wang Yonghua Qu Xinwei Wang Fangming Wu Yuke Zhou | 2019 | Science Bulletin2019，64，17： | 10 |
| 5 | Wearable skin-like optoelectronic systems with suppression of motion artifacts for cuff-less continuous blood pressure monitor显示文摘According to the statistics of the World Health Organization,an estimated 17.9 million people die from cardiovascular diseases each year,representing 31%of all global deaths.Continuous non-invasive arterial pressure(CNAP)is essential for the management of cardiovascular diseases.However,it is difficult to achieve long-term CNAP monitoring with the daily use of current devices due to irritation of the skin as well as the lack of motion artifacts suppression.Here,we report a high-performance skin-like optoelectronic system integrated with ultra-thin flexible circuits to monitor CNAP.We introduce a theoretical model via the virtual work principle for predicting the precise blood pressure and suppressing motion artifacts,and propose optical difference in the frequency domain for stable optical measurements in terms of skin-like devices.We compare the results with the blood pressure acquired by invasive(intra-arterial)blood pressure monitoring for>1500 min in total on 44 subjects in an intensive care unit.The maximum absolute errors of diastolic and systolic blood pressure were±7/±10 mm Hg,respectively,in immobilized,and±10/±14 mm Hg,respectively,in walking scenarios.These strategies provide advanced blood pressure monitoring techniques,which would directly address an unmet clinical need or daily use for a highly vulnerable population. | Haicheng Li Yinji Ma Ziwei Liang Zhouheng Wang Yu Cao Yuan Xu Hua Zhou Bingwei Lu Ying Chen Zhiyuan Han Shisheng Cai Xue Feng | 2020 | National Science Review2020，7，5： | 7 |
| 6 | Recent progress of integrated circuits and optoelectronic chips显示文摘Integrated circuits(ICs)and optoelectronic chips are the foundation stones of the modern information society.The IC industry has been driven by the so-called'Moore's law'in the past 60 years,and now has entered the post Moore's law era.In this paper,we review the recent progress of ICs and optoelectronic chips.The research status,technical challenges and development trend of devices,chips and integrated technologies of typical IC and optoelectronic chips are focused on.The main contents include the development law of IC and optoelectronic chip technology,the IC design and processing technology,emerging memory and chip architecture,brain-like chip structure and its mechanism,heterogeneous integration,quantum chip technology,silicon photonics chip technology,integrated microwave photonic chip,and optoelectronic hybrid integrated chip. | Yue HAO Shuiying XIANG Genquan HAN Jincheng ZHANG Xiaohua MA Zhangming ZHU Xingxing GUO Yahui ZHANG Yanan HAN Ziwei SONG Yan LIU Ling YANG Hong ZHOU Jiangyi SHI Wei ZHANG Min XU Weisheng ZHAO Biao PAN Yangqi HUANG Qi LIU Yimao CAI Jian ZHU Xin OU Tiangui YOU Huaqiang WU Bin GAO Zhiyong ZHANG Guoping GUO Yonghua CHEN Yong LIU Xiangfei CHEN Chunlai XUE Xingjun WANG Lixia ZHAO Xihua ZOU Lianshan YAN Ming LI | 2021 | Science China(Information Sciences)2021，64，10： | 7 |
| 7 | Enhancement of precursor amino acid supplies for improving bacitracin production by activation of branched chain amino acid transporter BrnQ and deletion of its regulator gene lrp in Bacillus licheniformis显示文摘Bacitracin,a new type of cyclic peptide antibiotic,is widely used as the feed additive in feed industry.Branched chain amino acids(BCAAs)are the key precursors for bacitracin synthesis.In this research,soybean meal was served as the raw material to supply precursor amino acids for bacitracin synthesis,and enhanced production of bacitracin was attempted by engineering BCAA transporter BrnQ and its regulator Lrp in the bacitracin industrial production strain Bacillus licheniformis DW2.Firstly,our results confirmed that Lrp negatively affected bacitracin synthesis in DW2,and deletion of lrp improved intracellular BCAA accumulations,as well as the expression level of BCAA transporter BrnQ,which further led to a 14.71%increase of bacitracin yield,compared with that of DW2.On the contrary,overexpression of Lrp decreased bacitracin yield by 12.28%.Secondly,it was suggested that BrnQ acted as a BCAA importer in DW2,and overexpression of BrnQ enhanced the intracellular BCAA accumulations and 10.43%of bacitracin yield.While,the bacitracin yield decreased by 18.27%in the brnQ deletion strain DW2△brnQ.Finally,BrnQ was further overexpressed in lrp deletion strain DW2△lrp,and bacitracin yield produced by the final strain DW2△lrp::BrnQ was 965.34 U/mL,increased by 22.42%compared with that of DW2(788.48 U/mL).Collectively,this research confirmed that Lrp affected bacitracin synthesis via regulating the expression of BCAA transporter BrnQ and BCAA distributions,and provided a promising strain for industrial production of bacitracin. | Jiang Zhu Dongbo Cai Haixia Xu Ziwei Liu Bowen Zhang Fei Wu Junhui Li Shouwen Chen | 2018 | Synthetic and Systems Biotechnology2018，3，4： | 6 |
| 8 | Occurrence and bioaccumulation of polybrominated diphenyl ethers in sediments and paddy ecosystems of Liaohe River Basin, northeast China显示文摘Concentrations of 16 polybrominated diphenyl ether(PBDE) congeners were measured in river sediments, paddy soils and three species of paddy-field organisms(crab, loach and carp) collected from the Liaohe River Basin, northeastern China. The total contents of PBDEs(∑_(16)PBDEs) in sediments and paddy soils were in the ranges of 273.4–3246.3 pg/g dry weight(dw), and 192.1–1783.8 pg/g dw, respectively. BDE 209 was the dominant congener both in sediments and paddy soils. The concentrations of ∑_(16)PBDEs in sediments were significantly higher than those in the adjacent paddy soils, indicating a potential transport of PBDEs from river to paddy ecosystems via river water irrigation. The biota–soil accumulation factor(BSAF) was calculated as the ratio between the lipid-normalized concentration in paddyfield organisms and the total organic carbon-normalized concentration in paddy soil. The average BSAF values of ∑15PBDEs followed the sequence of crab(3.6) > loach(3.3) > carp(2.1). BDE 154 had the highest BSAF value, and a parabolic trend between BSAF values of individual PBDE congeners and their log KOWvalues was observed. In view of the fact that crab had the larger BSAF value and higher lipid content, the ecological risk and health risk for crab cultivation in paddy fields should be of particular concern. | Xindong Ma Haijun Zhang Wenjun Yao Wen Guo Depeng Li Ziwei Yao Jiping Chen | 2016 | Journal of Environmental Sciences2016，28，5： | 6 |
| 9 | Ultrasonication-assisted and gram-scale synthesis of Co-LDH nanosheet aggregates for oxygen evolution reaction显示文摘Electrochemical water splitting(EWS)is a highly clean and efficient method for high-purity hydrogen production.Unfortunately,EWS suffers from the sluggish and complex oxygen evolution reaction(OER)kinetics at anode.At present,the efficient,stable,and low-cost non-precious metal based OER electrocatalyst is still a great and long-term challenge for the future industrial application of EWS technology.Herein,we develop a simple and fast approach for gram-scale synthesis of flower-like cobalt-based layered double hydroxides nanosheet aggregates by ultrasonic synthesis,which show outstanding electrocatalytic performance for the oxygen evolution reaction in alkaline media,such as preeminent stability,small overpotential of 300 mV at 10 mA·cm^−2 and small Tafel slope of 110 mV·dec^−1. | Tian-Jiao Wang Xiaoyang Liu Ying Li Fumin Li Ziwei Deng Yu Chen | 2020 | Nano Research2020，13，1： | 5 |
| 10 | Determining the microstructure and properties of magnesium aluminum composite panels by hot rolling and annealing显示文摘The researchers made magnesium aluminum composite panels by asymmetric metal packaging and studied rolling temperature,holding time,and high temperature heat treatment,such as short time and low temperatures over long periods of time parameters under the new preparation method.We tested the new magnesium aluminum composite panels’tensing properties and bending performance by using scanning electric mirror and EDS.It is concluded that the new magnesium aluminum composite panels’elongation is 24%under the tensile strength of 260 MPa.Regarding performance when compared with other methods,traditional magnesium aluminum composite panels’elongation is 10%,which shows its advanced nature.At the same time,bending performance test showed that the combination of the composite board has higher performance,offering the reference value for the preparation of magnesium–aluminum composite plate. | Zilong Zhao Qiang Gao Junfeng Hou Ziwei Sun Fei Chen | 2016 | Journal of Magnesium and Alloys2016，4，3： | 4 |
| 11 | Multiplex precision gene editing by a surrogate prime editor in rice显示文摘Dear Editor,Development of a multiplex precision gene editing system is highly desirable for pyramiding beneficial alleles in crop improve-ment.Prime editing is a newly developed genome-editing tool that can precisely enable the installation of all 12 nucleotide sub-stitutions,short insertions,and deletions without exogenous DNA donor repair template and double-strand breaks(Anzalone et al.,2019).Among the prime editing systems,prime editor 3(PE3),which consists of a prime editing guide RNA(pegRNA)and an additional nicking single guide RNA(sgRNA)to nick the non-edited strand,enhances editing efficiency. | Huiyuan Li Ziwei Zhu Shaoya Li Jingying Li Lei Yan Chen Zhang Youzhi Ma Lanqin Xia | 2022 | Molecular Plant2022，15，7： | 4 |
| 12 | A fully automated centrifugal microfluidic system for sample-to-answer viral nucleic acid testing显示文摘The outbreak of virus-induced infectious diseases poses a global public-health challenge.Nucleic acid amplification testing(NAAT)enables early detection of pandemic viruses and plays a vital role in preventing onward transmission.However,the requirement of skilled operators,expensive instrumentation,and biosafety laboratories has hindered the use of NAAT for screening and diagnosis of suspected patients.Here we report development of a fully automated centrifugal microfluidic system with sample-in-answer-out capability for sensitive,specific,and rapid viral nucleic acid testing.The release of nucleic acids and the subsequent reverse transcription loop-mediated isothermal amplification(RT-LAMP)were integrated into the reaction units of a microfluidic disc.The whole processing steps such as injection of reagents,fluid actuation by rotation,heating and temperature control,and detection of fluorescence signals were carried out automatically by a customized instrument.We validate the centrifugal microfluidic system using oropharyngeal swab samples spiked with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)armored RNA particles.The estimated limit of detection for armored RNA particles is 2 copies per reaction,the throughput is 21 reactions per disc,and the assay sample-to-answer time is approximately 70 min.This enclosed and automated microfluidic system efficiently avoids viral contamination of aerosol,and can be readily adapted for virus detection outside the diagnostic laboratory. | Fei Tian Chao Liu Jinqi Deng Ziwei Han Lu Zhang Qinghua Chen Jiashu Sun | 2020 | Science China Chemistry2020，63，10： | 4 |
| 13 | SOX4 contributes to TGF-β-induced epithelialemesenchymal transition and stem cell characteristics of gastric cancer cells显示文摘SOX4 is highly expressed in gastric cancer(GC)and is associated with tumor grade,metastasis and prognosis,however the mechanism is not clear.We report herein that SOX4 was upregulated and overexpression of SOX4 was associated with increased expression of the markers of Epithelialemesenchymal transition(EMT)and stemness in clinic patient samples.In vitro,overexpression of SOX4 promoted the invasion as showed by Transwell assay and stemness of GC cells as assessed by sphere formation assay,which was suppressed by silencing SOX4 with shRNA.Further studies showed that SOX4 up-regulated the expression of EMT transcription factors Twist1,snail1 and zeb1 and stemness transcription factors SOX2 and OCT4,and promoted the nuclear translocation of β-catenin.Moreover,we revealed that TGF-β treatment significantly up-regulated the expression of SOX4 and silencing SOX4 reversed TGF-β induced invasion and sphere formation ability of GC cells.Finally,we showed that SOX4 promoted the lung metastasis and tumor formation ability of gastric cancer cells in nude mice.Our results suggest that SOX4 is a target TGF-β signaling and mediates TGF-β-induced EMT and stem cell characteristics of GC cells,revealing a novel role of TGF-β/SOX4 axis in the regulation of malignant behavior of GC. | Xudong Peng Guangyi Liu Hongxia Peng Anqi Chen Lang Zha Ziwei Wang | 2018 | Genes & Diseases2018，5，1： | 4 |
| 14 | Far-field coseismic gravity changes related to the 2015 MW7.8 Nepal(Gorkha)earthquake observed by superconducting gravimeters in Chinese mainland显示文摘Using data from five SGs at four stations in Chinese mainland,obvious permanent gravity changes caused by the 2015 MW7.8 Nepal(Gorkha)earthquake were detected.We analyzed the gravity effects from ground vertical deformation(VD)using co-site continuous GPS(cGPS)data collocated at the Lijiang and the Wuhan station,and hydrological effects using GLDAS models and groundwater level records.After removing these effects,SG observations before and after the earthquake revealed obvious permanent gravity changes:−3.0μGal,7.3μGal and 8.0μGal at Lhasa,Lijiang and Wuhan station,respectively.We found that the gravity changes cannot be explained by the results of dislocation theory. | LeLin Xing ZiWei Liu JianGang Jia ShuQing Wu ZhengSong Chen XiaoWei Niu | 2021 | Earth and Planetary Physics2021，5，2： | 4 |
| 15 | The osmolyte-producing endophyte Streptomyces albidoflavus OsiLf-2 induces drought and salt tolerance in rice via a multi-level mechanism显示文摘Drought and salinity are major environmental stresses that impair crop growth and productivity worldwide. Improving drought and salt tolerance of crops with microbial mutualists is an effective and environmentally sound strategy to meet the demands of the ever-growing world population. In the present study, we found that the Streptomyces albidoflavus Osi Lf-2, a moderately salt-tolerant endophytic actinomycete, produced abundant osmolytes, including proline, polysaccharides, and ectoine. Inoculation with Osi Lf-2 increased the osmotic-adjustment ability of the rice host by increasing the proline content(by250.3% and 49.4%) and soluble sugar(by 20.9% and 49.4%) in rice under drought and salt conditions, relative to the uninoculated control. Osi Lf-2 increased stress responses in the rice host at the physiological and biochemical levels(photosynthesis efficiency, osmolytes and antioxidant content), and the gene level(osmolytes synthesis, stress-responsive and ion-transport related genes), raising rice yields under both greenhouse and saline–alkaline soil conditions. The use of endophytic actinomycetes offers a promising biotechnological approach to developing stress-tolerant plants. | Shuqi Niu Yan Gao Huixian Zi Ying Liu Xuanming Liu Xianqiu Xiong Qingqing Yao Ziwei Qin Ning Chen Liang Guo Yuanzhu Yang Peng Qin Jianzhong Lin Yonghua Zhu | 2022 | The Crop Journal2022，10，2： | 3 |
| 16 | A preference-based multi-objective building performance optimization method for early design stage显示文摘A large number of cases show that the multi-objective optimization method can significantly improve building performance.The method for multi-objective building performance optimization(BPO)design has achieved rapid development in recent years.However,the BPO method still needs to be improved.Specifically,weak interaction between the optimization process and the decision-making process results in low optimization efficiency,which limits the widespread application of the optimization method in early design stage.In this paper,a new interactive BPO mode is explored to strengthen the interaction between the optimization process and decisionmaking process,and a preference-based multi-objective BPO method is proposed to account for designers'decision preferences during the optimization process,making the objective more controllable,improving the optimization efficiency and ensuring the diversity of solutions.Firstly,this paper illustrates the proposed method in detail,defines the concept of performance preference,expounds the flow of the preference-based multi-objective optimization algorithm,and proposes three indicators to evaluate the algorithm,which includes convergence speed,preference satisfaction rate,and diversity measurement.Secondly,through testing and comparison,it is found that the proposed preference-based algorithm has advantages over the non-preference optimization algorithm(represented by the NSGA-II algorithm).The proposed method leads to faster convergence and higher preference satisfaction,so it is more suitable for the BPO process in the early design stage.Specially,the proposed method can achieve 100%preference satisfaction rate with only 2400 simulations,while the non-preference method can only achieve 20%preference satisfaction rate after 5800 simulations.In this paper,a preference-based multi-objective BPO method is proposed to make the optimization process closely interact with the decision-making process and make the design preferences be accounted during the BPO process,thereby improving the optimization efficiency.In addition,this study first proposes two indicators to measure the quality of optimization results:preference satisfaction rate and diversity measurement.This study aims to guide the development of BPO methods towards providing high satisfaction rate and high quality optimization results. | Borong Lin Hongzhong Chen Yanchen Liu Qiushi He Ziwei Li | 2021 | Building Simulation2021，14，3： | 3 |
| 17 | Kidney injury molecule-1 is a potential receptor for SARS-CoV-2显示文摘COVID-19 patients present high incidence of kidney abnormalities,which are associated with poor prognosis and mortality.The identification of SARS-CoV-2 in the kidney of COVID-19 patients suggests renal tropism of SARS-CoV-2.However,whether there is a specific target of SARS-CoV-2 in the kidney remains unclear.Herein,by using in silico simulation,coimmunoprecipitation,fluorescence resonance energy transfer,fluorescein isothiocyanate labeling,and rational design of antagonist peptides,we demonstrate that kidney injury molecule-1(KIM1),a molecule dramatically upregulated upon kidney injury,binds with the receptor-binding domain(RBD)of SARS-CoV-2 and facilitates its attachment to cell membrane,with the immunoglobulin variable Ig-like(Ig V)domain of KIM1 playing a key role in this recognition.The interaction between SARS-CoV-2 RBD and KIM1 is potently blockaded by a rationally designed KIM1-derived polypeptide AP2.In addition,our results also suggest interactions between KIM1 Ig V domain and the RBDs of SARS-CoV and MERS-CoV,pathogens of two severe infectious respiratory diseases.Together,these findings suggest KIM1 as a novel receptor for SARS-CoV-2 and other coronaviruses.We propose that KIM1 may thus mediate and exacerbate the renal infection of SARS-CoV-2 in a‘vicious cycle’,and KIM1 could be further explored as a therapeutic target. | Chen Yang Yu Zhang Xia Zeng Huijing Chen Dong Yang Yuchen Chen Ziwei Shen Xiaomu Wang Xinran Liu Mingrui Xiong Hong Chen Kun Huang | 2021 | Journal of Molecular Cell Biology2021，13，3： | 2 |
| 18 | Explore the QCD phase transition phenomena from a multiphase transport model显示文摘We study the phase structure of QCD matter in the framework of a multiphase transport model by implementing a strong local parton density fluctuation scenario. Our calculations on the beam energy dependence of net-proton high moment show that local parton density fluctuation only has a small effect. But it becomes important when all baryons are included. We then study the effect on elliptic flow and find that an enhanced local parton density fluctuation leads to a significant effect on protons but a small effect on pions. Our study provides a reference of transport dynamics on QCD phase transition phenomena and will be relevant for the upcoming phase II of the beam energy scan program at RHIC. | XiaoHai Jin JinHui Chen ZiWei Lin GuoLiang Ma YuGang Ma Song Zhang | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，1： | 2 |
| 19 | Direct van der Waals epitaxial growth of 1D/2D Sb2Se3/WS2 mixed-dimensional p-n heterojunctions显示文摘The mixed-dimensional integration of two-dimensional (2D) materials with non-2D materials can give rise to prominent advances in performance or function.To date,the mixed-dimensional one-dimensional (1D)/2D heterostructures have been fabricated using various physical assembly approaches.However,direct epitaxial growth method which has notable advantages in preparing large-scale products and obtaining perfect interfaces is rarely investigated.Herein,we demonstrate for the first time the direct synthesis of the 1D/2D mixed-dimensional heterostructures by sequential vapor-phase growth of Sb2Se3 nanowires on WS2 monolayers.X-ray diffraction (XRD) pattern and Raman spectrum confirm the composition of the Sb2Se3/NS2 heterostructures.Transmission electron microscope (TEM) measurement demonstrates high quality of the heterostructures.Electrical transport characterization reveals that Sb2Se3 nanowire exhibits p-type characteristic and that WS2 monolayer exhibits n-type behavior,and that the p-n diode from 1D/2D mixed-dimensional Sb2Se3/WS2 heterostructure possesses obvious current rectification behavior.Optoelectronic measurements of the heterostructures show apparent photovoltaic response with an open-circuit voltage of 0.19 V,photoresponsivity of 1.51 A/W (Vds =5 V) and fast response time of less than 8 ms.The van der Waals epitaxial growth mode of Sb2Se3 nanowires on WS2 monolayers is verified by stripping the Sb2Se3 nanowire from the heterostructures using tape.Together,the direct van der Waals epitaxy opens a facile pathway to 1D/2D mixed-dimensional heterostructures for functional electronic and optoelectronic devices. | Guangzhuang Sun Bo Li Jia Li Zhengwei Zhang Huifang Ma Peng Chen Bei Zhao Ruixia Wu Weiqi Dang Xiangdong Yang Xuwan Tang Chen Dai Ziwei Huang Yuan Liu Xidong Duan Xiangfeng Duan | 2019 | Nano Research2019，12，5： | 2 |
| 20 | 对比经肛全直肠系膜切除术与腹腔镜全直肠系膜切除术:一项多中心III期随机临床试验(TaLaR试验)方案显示文摘背景:全直肠系膜切除术是直肠癌治疗的标准手术方法。经肛全直肠系膜切除术(taTME)是治疗低位直肠癌的新术式。既往研究表明,与腹腔镜全直肠系膜切除术(lapTME)相比,taTME应用于低位直肠癌患者可提供更高质量的手术标本,但其长期肿瘤学结果仍需进一步观察。因此,我们设计了这个非劣效性临床试验(TaLaR试验),比较taTME与lapTME治疗直肠癌的短期和长期结果。方法/设计:TaLaR试验是一项多中心III期随机对照试验。研究对象为经磁共振成像、直肠指检或结肠镜检查被诊断为位于腹膜反折以下的直肠癌,若肿瘤分期≤cT3N2直接手术,若>cT3N2则先行新辅助治疗。通过计算,本研究需纳入1,114例患者(每组557例)。纳入病例随机分配到taTME或lapTME组。本研究的主要终点是3年无病生存率(DFS)和5年总生存率(OS)。次要终点包括手术标本质量、围手术期结果、骨盆和肛门功能以及生活质量。讨论:我们认为,TaLaR试验将阐明taTME是否可以达到与lapTME相似的肿瘤学结果,以及是否可改善直肠癌患者的手术标本质量及恢复情况。 | Liang Kang Ziwei Zeng Shuangling Luo Hong Zhang Quan Wang Mingyang Ren Miao Wu Weidong Tong Qing Xu Yi Xiao Aiwen Wu Yuan-Guang Chen Bo Feng Zhanlong Shen Liang Huang Xingwei Zhang Minhua Zheng Jian-Ping Wang | 2021 | Gastroenterology Report2021，9，1： | 2 |
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