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| 1 | Visual Object Tracking and Servoing Control of a Nano-Scale Quadrotor:System,Algorithms,and Experiments显示文摘There are two main trends in the development of unmanned aerial vehicle(UAV)technologies:miniaturization and intellectualization,in which realizing object tracking capabilities for a nano-scale UAV is one of the most challenging problems.In this paper,we present a visual object tracking and servoing control system utilizing a tailor-made 38 g nano-scale quadrotor.A lightweight visual module is integrated to enable object tracking capabilities,and a micro positioning deck is mounted to provide accurate pose estimation.In order to be robust against object appearance variations,a novel object tracking algorithm,denoted by RMCTer,is proposed,which integrates a powerful short-term tracking module and an efficient long-term processing module.In particular,the long-term processing module can provide additional object information and modify the short-term tracking model in a timely manner.Furthermore,a positionbased visual servoing control method is proposed for the quadrotor,where an adaptive tracking controller is designed by leveraging backstepping and adaptive techniques.Stable and accurate object tracking is achieved even under disturbances.Experimental results are presented to demonstrate the high accuracy and stability of the whole tracking system. | Yuzhen Liu Ziyang Meng Yao Zou Ming Cao | 2021 | IEEE/CAA Journal of Automatica Sinica2021，8，2： | 4 |
| 2 | Full-spectrum cell-free RAN for 6G systems:system design and experimental results显示文摘With distributed transceivers and scalable cooperative transmission,cell-free massive multipleinput multiple-output(CF-mMIMO)technology eliminates the“cells”of traditional mobile communications,thereby significantly improving the performance of wireless networks.CF-mMIMO is considered as a major technical tool for achieving the key performance indicators of sixth generation(6G)mobile communication systems.In this paper,a scalable implementation architecture for CF-mMIMO is proposed,based on which potential key technologies such as channel information acquisition,transceiver design,dynamic user and access point association,and novel duplexing are introduced.Finally,based on low-cost commercial access points,a CF-mMIMO testbed with 64 transmit and receive antennas is developed,and the performance of the distributed receiver design is evaluated. | Dongming WANG Xiaohu YOU Yongming HUANG Wei XU Jiamin LI Pengcheng ZHU Yanxiang JIANG Yang CAO Xinjiang XIA Ziyang ZHANG Qingji JIANG Pan WANG Dongjie LIU Kang ZHENG Mengting LOU Jing JIN Qixing WANG Jiangzhou WANG | 2023 | Science China(Information Sciences)2023，66，3： | 3 |
| 3 | Erratum on “Engineering of a universal polymeric nanoparticle platform to optimize the PEG density for photodynamic therapy” [Sci. China. Chem., 2019, 62: 1379–1386]显示文摘In a recent publication [1], these images in Figures 6(b, c)(^NPEG-NPCe6 group), S7, S9 and S10 were inadvertently taken the incorrect images in the production. The corrected versions are shown below. And, the quantification of Ce6 fluorescence(as performed in Figure 6(c)) was also corrected(Figure S12). | Xixi Yang Jie Li Yue Yu Junxia Wang Dongdong Li Ziyang Cao Xianzhu Yang | 2019 | Science China Chemistry2019，62，10： | 2 |
| 4 | Engineering of a universal polymeric nanoparticle platform to optimize the PEG density for photodynamic therapy显示文摘Nanocarrier-mediated photodynamic therapy(PDT)has attracted extensive attention due to its locoregional therapeutic effect,minimal toxicity to normal tissues,and activation of immune system capability.However,it is still unclear how the physicochemical properties of nanocarriers affect their PDT therapeutic efficacies,which could be very different from those for chemotherapy.Herein,to demonstrate the effect of PEG density on PDT efficacy,we synthesized a series of random polyphosphoesters(PPEs)with different PEG contents by regulating the molar ratios of these monomers,and then these PPEs were used to prepare chlorin e6(Ce6)-loaded polymeric nanoparticles with tunable PEG density.Thereafter,the PDT efficacies of these nanoparticles were carefully and comprehensively evaluated.We demonstrate that the moderate PEG density(3.01 PEG/nm^2)of nanocarrier exhibited the best PDT therapeutic efficacy in a mouse model of pancreatic cancer due to its efficient balance of prolonged circulation and tumor cellular uptake. | Xixi Yang Jie Li Yue Yu Junxia Wang Dongdong Li Ziyang Cao Xianzhu Yang | 2019 | Science China Chemistry2019，62，10： | 1 |
| 5 | Pharmacological inhibition of BAP1 recruits HERC2 to competitively dissociate BRCA1-BARD1, suppresses DNA repair and sensitizes CRC to radiotherapy显示文摘Radiotherapy is widely used in the management of advanced colorectal cancer(CRC).However,the clinical efficacy is limited by the safe irradiated dose.Sensitizing tumor cells to radiotherapy via interrupting DNA repair is a promising approach to conquering the limitation.The BRCA1-BARD1 complex has been demonstrated to play a critical role in homologous recombination(HR)DSB repair,and its functions may be affected by HERC2 or BAP1.Accumulated evidence illustrates that the ubiquitination-deubiquitination balance is involved in these processes;however,the precise mechanism for the cross-talk among these proteins in HR repair following radiation hasn’t been defined.Through activity-based profiling,we identified PT33 as an active entity for HR repair suppression.Subsequently,we revealed that BAP1 serves as a novel molecular target of PT33 via a CRISPR-based deubiquitinase screen.Mechanistically,pharmacological covalent inhibition of BAP1 with PT33 recruits HERC2 to compete with BARD1 for BRCA1 interaction,interrupting HR repair.Consequently,PT33 treatment can substantially enhance the sensitivity of CRC cells to radiotherapy in vitro and in vivo.Overall,these findings provide a mechanistic basis for PT33-induced HR suppression and may guide an effective strategy to improve therapeutic gain. | Xin Yue Tingyu Liu Xuecen Wang Weijian Wu Gesi Wen Yang Yi Jiaxin Wu Ziyang Wang Weixiang Zhan Ruirui Wu Yuan Meng Zhirui Cao Liyuan Le Wenyan Qiu Xiaoyue Zhang Zhenyu Li Yong Chen Guohui Wan Xianzhang Bu Zhenwei Peng Ran-yi Liu | 2023 | Acta Pharmaceutica Sinica B2023，13，8： | 1 |
| 6 | Decentralized finite-time sliding mode estimators and their applications in decentralized finite-time formation tracking显示文摘 | Yongcan Cao Wei Ren Ziyang Meng | 2010 | Systems & Control Letters2010，，9： | 1 |
| 7 | A homologous and molecular dual-targeted biomimetic nanocarrier for EGFR-related non-small cell lung cancer therapy显示文摘The abnormal activation of epidermal growth factor receptor(EGFR)drives the development of non-small cell lung cancer(NSCLC).The EGFR-targeting tyrosine kinase inhibitor osimertinib is frequently used to clinically treat NSCLC and exhibits marked efficacy in patients with NSCLC who have an EGFR mutation.However,free osimertinib administration exhibits an inadequate response in vivo,with only~3%patients demonstrating a complete clinical response.Consequently,we designed a biomimetic nanoparticle(CMNP^(@Osi))comprising a polymeric nanoparticle core and tumor cell-derived membrane-coated shell that combines membrane-mediated homologous and molecular targeting for targeted drug delivery,thereby supporting a dual-target strategy for enhancing osimertinib efficacy.After intravenous injection,CMNP^(@Osi)accumulates at tumor sites and displays enhanced uptake into cancer cells based on homologous targeting.Osimertinib is subsequently released into the cytoplasm,where it suppresses the phosphorylation of upstream EGFR and the downstream AKT signaling pathway and inhibits the proliferation of NSCLC cells.Thus,this dual-targeting strategy using a biomimetic nanocarrier can enhance molecular-targeted drug delivery and improve clinical efficacy. | Bin Xu Fanjun Zeng Jialong Deng Lintong Yao Shengbo Liu Hengliang Hou Yucheng Huang Hongyuan Zhu Shaowei Wu Qiaxuan Li Weijie Zhan Hongrui Qiu Huili Wang Yundong Li Xianzhu Yang Ziyang Cao Yu Zhang Haiyu Zhou | 2023 | Bioactive Materials2023，，9： | 1 |
| 8 | Super enhancers:Pathogenic roles and potential therapeutic targets for acute myeloid leukemia(AML)显示文摘Acute myeloid leukemia(AML)is a malignant hematological tumor with disordered oncogenes/tumor suppressor genes and limited treatments.The potent anti-cancer effects of bromodomain and extra-terminal domain(BET)inhibitors,targeting the key component of super enhancers,in early clinical trials on AML patients,implies the critical role of super enhancers in AML.Here,we review the concept and characteristic of super enhancer,and then summarize the current researches about super enhancers in AML pathogenesis,diagnosis and classification,followed by illustrate the potential super enhancer-related targets and drugs,and propose the future directions of super enhancers in AML.This information provides integrated insight into the roles of super enhancers in this disease. | Ziyang Cao Yi Shu Jinxia Wang Chunxia Wang Tienan Feng Li Yang Jingbo Shao Lin Zou | 2022 | Genes & Diseases2022，9，6： | 1 |
| 9 | Quantitative study of dimensional stability mechanism and microstructure evolution during precipitation process of 2024Al alloy显示文摘In this paper,we were devoted to quantitatively analyzing the dimensional change of 2024 Al alloy during the aging process.Types of precipitates have been defined and the corresponding volume fraction has been measured with Transmission Electron Microscopy(TEM)and Three-Dimensional Atom Probe Tomography(3 D-APT).Guinier-Preston-Bagaryatsky(GPB)zone(0.86 vol.%)was found after aging for 8 h.GPB zone(0.17 vol.%)and S'phase(1.02 vol.%)was found after aging for 24 h.The reduced dimensional change was attributed to the reduction of matrix lattice parameter.Relative to the initial supersaturated solid solution state,the lattice strain of-2.79×10^(-5)and-5.16×10^(-5)was produced after 8 h and 24 h aging respectively.The difference of the lattice parameters between the precipitates and matrix was also considered.A model was established to quantitatively describe the relationship between the precipitation process and dimensional change of 2024 Al alloy. | Youfang Cao Longtao Jiang Deng Gong Guoqin Chen Ziyang Xiu Yangming Cheng Xiufang Wang Gaohui Wua | 2021 | Journal of Materials Science & Technology2021，，31： | 1 |
| 10 | Single-cell transcriptomics of immune cells in lymph nodes reveals their composition and alterations in functional dynamics during the early stages of bubonic plague显示文摘Bubonic plague caused by Yersinia pestis is highly infectious and often fatal.Characterization of the host immune response and its subsequent suppression by Y.pestis is critical to understanding the pathogenesis of Y.pestis.Here,we utilized single-cell RNA sequencing to systematically profile the transcriptomes of immune cells in draining lymph nodes(d LNs)during the early stage of Y.pestis infection.Dendritic cells responded to Y.pestis within 2 h post-infection(hpi),followed by the activation of macrophages/monocytes(Mφs/Mons)and recruitment of polymorphonuclear neutrophils(PMNs)to d LNs at 24 hpi.Analysis of cell-to-cell communication suggests that PMNs may be recruited to lymph nodes following the secretion of CCL9 by Mφs/Mons stimulated through CCR1-CCL9 interaction.Significant functional suppression of all the three innate immune cell types occurred during the early stage of infection.In summary,we present a dynamic immune landscape,at single-cell resolution,of murine d LNs involved in the response to Y.pestis infection,which may facilitate the understanding of the plague pathogenesis of during the early stage of infection. | Yifan Zhao Tong Wang Ziyang Liu Yuehua Ke Ruoyan Li Hongyan Chen Yang You Gengshan Wu Shiyang Cao Zongmin Du Fan Bai Ruifu Yang | 2023 | Science China(Life Sciences)2023，66，1： | 0 |
| 11 | Meta-Analysis on Efficacy of Vaccination against Staphylococcus aureus and Escherichia coli显示文摘Mastitis is a common disease responsible for the biggest economic loss in the dairy industry.Antibiotic therapy does not provide long-term protection.And residue is a major concern in food safety.Vaccination is an alternative control method with great potential for bovine mastitis.Our study focus on evaluating vaccine efficacy regarding reducing the incidence of clinical and subclinical mastitis.Meta-analysis was used to pool data extracted from previous studies.26 records from 13 studies were examined.A fixed effect model was constructed assigning incidence as the measurement of the outcome.Risk ratio(RR)was the parameter that measured the incidence differences between treated group and control group.Studies and records were categorised based on vaccine antigens.In vaccine against Staphylococcus aureus,RR was 0.76;95%CI(0.65,0.89),while in vaccine against Escherichia coli RR was 0.96;95%CI(0.86,1.08). | Ziyang Fu Haikun Liu Hong Cao Yongqiang Wang | 2020 | Veterinary Science Research2020，2，1： | 0 |
| 12 | Synchronous post-acceleration of laser-driven protons in helical coil targets by controlling the current dispersion显示文摘Post-acceleration of protons in helical coil targets driven by intense,ultrashort laser pulses can enhance ion energy by utilizing the transient current from the targets’self-discharge.The acceleration length of protons can exceed a few millimeters,and the acceleration gradient is of the order of GeV/m.How to ensure the synchronization between the accelerating electric field and the protons is a crucial problem for efficient post-acceleration.In this paper,we study how the electric field mismatch induced by current dispersion affects the synchronous acceleration of protons.We propose a scheme using a two-stage helical coil to control the current dispersion.With optimized parameters,the energy gain of protons is increased by four times.Proton energy is expected to reach 45 MeV using a hundreds-of-terawatts laser,or more than 100 MeV using a petawatt laser,by controlling the current dispersion. | Zhipeng Liu Zhusong Mei Defeng Kong Zhuo Pan Shirui Xu Ying Gao Yinren Shou Pengjie Wang Zhengxuan Cao Yulan Liang Ziyang Peng Jiarui Zhao Shiyou Chen Tan Song Xun Chen Tianqi Xu Xueqing Yan Wenjun Ma | 2023 | High Power Laser Science and Engineering2023，11，4： | 0 |
| 13 | The acceleration degradation processes of different aged refuses with the forced aeration for landfill reclamation显示文摘Forced aeration is one of the promising ways to accelerate landfill reclamation,and understanding the relation between aeration rates and waste properties is the prerequisite to implementing forced aeration under the target of energy saving and carbon reduction.In this work,landfill reclamation processes with forced aeration were simulated using aged refuses(ARs)of 1,4,7,10,and 13 disposal years,and the potential of field application was also investigated based on a field project,to identify the degradation rate of organic components,the O_(2)consumption efficiency and their correlations to microbes.It was found that the removal rate of organic matter declined from 20.3%(AR_(1))to 12.6%(AR_(13)),and that biodegradable matter(BDM)decreased from 5.2%to 2.4%at the set aeration rate of 0.12 L O_(2)/kg waste(Dry Matter,DM)/day.A linear relationship between the degradation rate constant(K)of BDM and disposal age(x)was established:K=−0.0002193x+0.0091(R^(2)=0.854),suggesting that BDM might be a suitable indicator to reflect the stabilization of ARs.The cellulose/lignin ratio decrease rate for AR1(18.3%)was much higher than that for AR13(3.1%),while the corresponding humic-acid/fulvic-acid ratio increased from 1.44 to 2.16.The dominant bacteria shifted from Corynebacterium(9.2%),Acinetobacter(6.6%),and Fermentimonas(6.5%),genes related to the decompose of biodegradable organics,to Stenotrophomonas(10.2%)and Clostridiales(3.7%),which were associated with humification.The aeration efficiencies of lab-scale tests were in the range of 5.4–11.8 g BDM/L O_(2)for ARs with disposal ages of 1–13 years,and in situ landfill reclamation,ARs with disposal ages of 10–18 years were around 1.9–8.8 g BDM/L O_(2),as the disposal age decreased.The increased discrepancy was observed in ARs at the lab-scale and field scale,indicating that the forced aeration rate should be adjusted based on ARs and the unit compartment combined,to reduce the operation cost. | Yihang Liu Chengqi Ning Qiujie Huang Zhaowen Cheng Weihua Cao Xianghui Wang Changfu Yang Hui Liu Jia Song Luochun Wang Ziyang Lou | 2023 | Waste Disposal and Sustainable Energy2023，5，3： | 0 |
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