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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Effect of Nb Solute and NbC Precipitates on Dynamic or Static Recrystallization in Nb Steels显示文摘Nb is often considered to be a powerful alloying element for controlling the recrystallization process in microalloyed high strength steels.However,Nb can be presented either as solute in solution,where it is thought to exhibit a strong solute drag effect,or as NbC precipitates,which are thought to be effective at pinning grain boundaries.Therefore,it is very important to quantitatively measure Nb in solution or in NbC precipitates.A quantitative analysis method of Nb in solution and in precipitates was proposed.The test procedure involved chemical dissolution,filtration and inductively coupled plasma atomic emission spectroscopic(ICP-AES) analysis.The amount of Nb in solution in Nb-microallyed steels under different treatment conditions was evaluated.The results show that the niobium and carbon contents in steels have a great effect on niobium dissolution kinetics.The solute Nb is more effective to retard dynamic recrystallization,while the NbC precipitates are more effective to inhibit static recrystallization.The results may help to comprehend effect of Nb in steels,and provide some guides in the design of new high strength Nb-bearing steels. | XIAO Fu-ren CAO Ya-bin QIAO Gui-ying ZHANG Xiao-bing LIAO Bo | 2012 | Journal of Iron and Steel Research(International)2012，19，11： | 21 |
| 3 | Endoscopic thyroidectomy: an evidence-based research on feasibility, safety and clinical effectiveness显示文摘背景内视镜的甲状腺切除的可行性和安全被出版研究的系统的评论的一条途径在过去的 decade.Methods 评估寻找的一个数据库在 MEDLINE 上被执行,系统的评论的 Cochrane 数据库,医生杂志俱乐部的美国学院,效果的评论的摘要的数据库,控制试用的 Cochrane 中央收款机。关于内视镜的甲状腺切除的比较级和非比较的研究被选择并且分析。为比较研究, RevMan 4.2 被用于统计分析;并且为非比较的研究,数据分析被七比较级学习包含 367 个病人的社会科学统计套装软体 13.0 .Results 执行(帮助录像的甲状腺切除(大桶) , 174 个病人;常规甲状腺切除(CT ) , 193 个病人) 在 VAT-CT 被包括组。年龄,性,起作用的类型,和病理学的诊断是类似的。与 CT 相比,大桶的吝啬的起作用的时间显著地更长(大桶, 80.0 分钟;CT, 61.9 分钟, P < 0.01 ) ,但是手术后的医院停留更短(大桶, 1.7 天;CT, 2.5 天, P < 0.01 ) 。为大桶的复杂并发症率是 6.9% ,当那为 CT 是 9.3% 时(P=0.35 ) 。三研究分析了手术后的疼痛和化妆评估,并且显示 VAT 组比 CT 组优异,但是在元分析以后没有重要差别。包含 273 个病人的三比较研究(完全内视镜的甲状腺切除(TET ) , 145 个病人;CT, 128 个病人) 在 TET-CT 组被包括,结果通常类似于 VAT-CT 的组。有 18 和 14 非比较的研究,分别地报导大桶和 TET 的结果。大桶的吝啬的起作用的时间与为 TET 的 135.8 分钟相比是 76.8 分钟。手术后的医院停留分别地是为大桶和 TET 的 1.8 和 3.8 天。到为大桶和 TET 的开的外科的变换的率是类似的(大桶, 2.8% ;TET, 3.9% , P=0.105 ) 。为大桶的复杂并发症率是 8.6% ,当那为 TET 是 3.5% 时(P < 0.01 ) 。内视镜的甲状腺切除的可行性和安全开始被验证并且接受的结论,并且它应该被看作一种有效选择,以化妆结果和手术后的悲痛把一些优点提供给病人。 | CHEN Xiao-dong PENG Bing GONG Ri-xiang WANG Li LIAO Bo LI Chun-lin | 2008 | Chinese Medical Journal2008，，20： | 19 |
| 4 | Correlation between coagulation function, tumor stage and metastasis in patients with renal cell carcinoma: a retrospective study显示文摘背景在癌病人的凝结功能是反常的,但是在肾的房间癌,凝结功能的程度和关系仍然保持不清楚。这研究回顾地与 350 个连续病人的一个总数从 2004 ~ 2010 承认了到我们的泌尿学部门的肾的房间 carcinoma.Methods 在病人调查了在凝结功能,临床的阶段和转移之间的关系被 histolopathologic 检查与肾的房间癌诊断并且在这研究被包括。肾的良性的肿瘤的 231 个案例的一个总数被看作控制组。纤维蛋白原,凝血素时间,激活的部分 thromboplastin 时间和国际规范的比率在所有题目被评估。肿瘤尺寸,临床的阶段,淋巴节点转移,和远转移用外科手术前的血浆纤维蛋白原与肾的房间癌病人铺平的放射线学的成像, intraoperative 调查结果,和组织学的 studies.Results 被评估((383.9 朠慥r 吗?? | XIAO Bo MA Lu-lin ZHANG Shu-dong XIAO Chun-lei LU Jian HONG Kai LIAO Hong-yi | 2011 | Chinese Medical Journal2011，，8： | 18 |
| 5 | Effect of Nb on Mechanical Properties of HAZ for High-Nb X80 Pipeline Steels显示文摘The mechanical properties of heat affected zone(HAZ)of two commercial high-Nb X80grade pipeline steels with different alloy elements were investigated using thermal simulation performed on a Gleeble-3500thermal simulator.The results showed that the high-Nb steels have excellent weldability.Embrittlement regions appear in coarse grain heat affected zone(CGHAZ)and intercritically heat affected zone(ICHAZ);Softening region appears in fine-grain heat affected zone(FGHAZ),and the strength here was even lower than 555 MPa as required in the standard.Meanwhile,with the increase of heat input,the strength and the toughness of HAZ of steel with high Nb,C and lower alloy decrease notably.Therefore,take into account the welding procedure during manufacture of weld pipe,suitable amount of alloy elements,such as Cr,Ni,Cu,Mo and so on,is necessary for high Nb X80heavythick steel plate. | CHEN Xiao-wei LIAO Bo QIAO Gui-ying GU Yu WANG Xu XIAO Fu-ren | 2013 | Journal of Iron and Steel Research(International)2013，20，12： | 15 |
| 6 | Ciliary parathyroid hormone signaling activates transforming growth factor-βto maintain intervertebral disc homeostasis during aging显示文摘Degenerative disc disease(DDD) is associated with intervertebral disc degeneration of spinal instability. Here, we report that the cilia of nucleus pulposus(NP) cells mediate mechanotransduction to maintain anabolic activity in the discs. We found that mechanical stress promotes transport of parathyroid hormone 1 receptor(PTH1 R) to the cilia and enhances parathyroid hormone(PTH) signaling in NP cells. PTH induces transcription of integrin α_vβ_6 to activate the transforming growth factor(TGF)-β-connective tissue growth factor(CCN2)-matrix proteins signaling cascade. Intermittent injection of PTH(iPTH) effectively attenuates disc degeneration of aged mice by direct signaling through NP cells, specifically improving intervertebral disc height and volume by increasing levels of TGF-β activity, CCN2, and aggrecan. PTH1 R is expressed in both mouse and human NP cells. Importantly,knockout PTH1 R or cilia in the NP cells results in significant disc degeneration and blunts the effect of PTH on attenuation of aged discs. Thus, mechanical stress-induced transport of PTH1 R to the cilia enhances PTH signaling, which helps maintain intervertebral disc homeostasis, particularly during aging, indicating therapeutic potential of iPTH for DDD. | Liwei Zheng Yong Cao Shuangfei Ni Huabin Qi Zemin Ling Xin Xu Xuenong Zou Tianding Wu Ruoxian Deng Bo Hu Bo Gao Hao Chen Yusheng Li Jianxi Zhu Francis Tintani Shadpour Demehri Amit Jain Khaled M.Kebaish Shenghui Liao Cheryle A.Séguin Janet L.Crane Mei Wan Hongbin Lu Paul D.Sponseller Lee H.RileyIII Xuedong Zhou Jianzhong Hu Xu Cao | 2018 | Bone Research2018，6，3： | 13 |
| 7 | Interaction of methylenetetrahydrofolate reductase C677T,cytochrome P4502E1 polymorphism and environment factors in esophageal cancer in Kazakh population显示文摘AIM: To evaluate the association and interaction of genetic polymorphisms in methylenetetrahydrofolate reductase (MTHER) and cytochrome P4502E1 (CY-P4502E1), environment risk factors with esophageal cancer (EC) in Kazakh, a high EC incidence area of Xinjiang Uygur Autonomous Region, China.METHODS: A 1:2 matched case-control study was conducted with 120 cases of EC and 240 population-or hospital-based controls. The controls were matched for sex, nationality, area of residence and age within a 5-year difference. MTHER and CYP4502E1 genotypes were identified by PCR-based restriction fragment length polymorphism (RFLP). A conditional logistic regression model was established to identify risk factors. The strata method was adopted in interaction analysis. RESULTS: Low consumption of green vegetables and fresh fruits, alcohol drinking, and unsafe water (shallow well, or river) were found to be the risk factors for EC. Individuals with the MTHFR677 (C/T + T/T) genotype had a 2.62-fold (95% CI: 1.61-4.28) risk of developing EC compared with those who carried the C/C genotype. Individuals with the CYP4502E1C1/C1 genotype had a 3.00-fold (95% CI: 1.82-4.96) risk compared with those who carried the CYP4502E1 (C1/C2 + C2/C2) genotype.Gene-environment interaction analysis showed that MTHFR677 gene polymorphism was correlated with consumption of green vegetables and fresh fruit, while CYP4502E1 C1/C1 was correlated with alcohol drink-ing and unsafe drinking water. MTHFR and CYP4502E1 analysis of gene-gene interaction showed that individu-als with the MTHFR677 (C/T + T/T) and CYP4502E1C1/C1 genotypes had a 7.41-fold (95% CI: 3.60-15.25) risk of developing EC compared with those who carried the MTHFR677C/C and CYP4502E1 RsaI C1/C2 + C2/C2 genes, and the interaction rate was higher than that of the two factors alone. CONCLUSION: Low consumption of green vegetables and fresh fruits, alcohol drinking, and unsafe water (shallow well, or river) and polymorphisms in MTHFR and CYP4502E1 genes are important risk factors for EC. There is a synergistic interaction among polymorphisms in MTHFR and CYP4502E1 genes and environment factors. MTHFR and CYP4502E1 genes can be used as biomarkers for prevention of EC in Kazakh, Xinjiang Uygur Autonomous Region, China. | Jiang-Mei Qin Lei Yang Bo Chen Xiu-Mei Wang Feng Li Pei-Hua Liao Lin He | 2008 | World Journal of Gastroenterology2008，14，45： | 13 |
| 8 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 9 | A multiplex PCR for differential detection of Echinococcus granulosus sensu stricto,Echinococcus multilocularis and Echinococcus canadensis in China显示文摘Background:Echinococcosis caused byEchinococcus is one of the most major infectious diseases in north-west highland of China.E.granulosus sensu strict,E.multilocularis,andE.canadensis are known to be the only three species related to human health transmitting in the areas.To achieve targeted treatment and control of echinococcosis,the accurate identification and discrimination of the species are important.However,currently the available diagnostic approaches do not present ideal results either in accuracy or efficiency.Methods:In the study,a set of primers were designed to aim at the three human-pathogenicEchinococcus species in China.The one-step multiplex PCR assay was developed and evaluated for the specificity and sensitivity.A total of 73parasitic lesions and 41 fecal materials obtained from human and various animals collected in the clinic and the field were tested to assess the applicability of this method.Results:The multiplex PCR effectively detected the individual DNA from the targeted species and their random mixtures generating with distinguishable expected size of products.The detection limit of the assay for each of the three species was 5 pg/μl when they were tested separately.When DNA mixtures of the targeted species containing the same concentration were used as templates,the lowest amount of DNA which can be detected was 50 pg/μl,10 pg/μl and 5 pg/μl forE.granulosus s.s.,E.multilocularis,andE.canadensis respectively.No cross-reactivity was observed when DNA from eight genetically close species was used as control templates.The multiplex PCR identifications of all samples were in line with the original sequencing results except for those infected withE.shiquicus,which showed negative signals in the developed assay.Of all the tested stool materials,16 were previously found positive forEchinococcus by visual and microscopic examination.Among these 16 samples,13 were confirmed by the multiplex PCR,and the other three tested negative.Additionally,the multiplex PCR identified another 14 positive feces from the remained 25 stool samples which absence of worms.Conclusions:The developed multiplex PCR shows advantages in fast diagnosis and large-scale epidemiological investigation,which proven to be a promising tool utilized in clinic and surveillance system. | Jing-Ye Shang Guang-Jia Zhang Sha Liao Yan Huang Wen-Jie Yu Wei He Guang-You Yang Tiao-Ying Li Xing-Wang Chen Bo Zhong Qian Wang Qi Wang Rui-Rui Li Hao Wang | 2019 | Infectious Diseases of Poverty2019，8，4： | 11 |
| 10 | Ripening behavior of M_(23)C_6 carbides in P92 steel during aging at 800°C显示文摘The rapid coarsening of the M_(23)C_6 carbides has been held responsible for the creep fracture in 9-12Cr martensitic heat resistant steels.A commercial P92 steel was subjected to thermal aging at a high temperature of 800°C to investigate the ripening behavior of the M_(23)C_6 carbides.Scanning electron microscopy(SEM)and transmission electron microscopy(TEM)were employed to characterize the microstructure evolution,especially the ripening process of the M_(23)C_6 carbides.The new concept of the effective mean size,dependent on the critical radius,was introduced to correct the measured mean size and then the Ostwald theory was applied to describe the ripening behavior of the M_(23)C_6 carbides.The ripening of the M_(23)C_6 carbides was revealed to be grain boundary diffusion controlled. | Xu Yang Bo Liao Fu-ren Xiao Wei Yan Yi-yin Shan Ke Yang | 2017 | Journal of Iron and Steel Research(International)2017，24，8： | 10 |
| 11 | Profiling of microbial communities in a bioreactor for treating hydrocarbon-sulfide-containing wastewater显示文摘A technology of polymerase chain reaction-denaturing gradient gel electrophoresis(PCR-DGGE)was used to profile the structure and dynamic changes of microbial communities in a bioreactor for treating hydrocarbon-sulfide-containing(HSC)wastewater.The results showed that the heterotrophic genus of Acinetobacter and the autotrophic genera of Thiobacillus and Thiomonas could survive well in all of three operating conditions.Some special genera were also observed with changes of micro-ecoenvironment in the rea... | Liao Bo Ji Guodong Cheng Liqiu | 2008 | Journal of Environmental Sciences2008，20，8： | 10 |
| 12 | Risks faced by donors of right lobe for living donor liver transplantation显示文摘BACKGROUND:Because of the shortage of deceased donors with livers fit for transplantation,living donor liver transplantation(LDLT)is becoming an attractive alternative.Attention should be paid to the donors,especially to those of the right lobe.In this study,we evaluated the risks faced by donors of the right lobe for adult-to-adult LDLT.METHODS:The perioperative data from 105 consecutive living donors of the right lobe performed in West China Hospital from January 2002 to December 2007 were retrospectively studied.Preoperative evaluation included CT,MRCP,and intraoperative cholangiography,showing liver volume,hepatic vasculature and the biliary system.The standard liver volume(SLV)and the ratio of left lobe volume to SLV were calculated.The right lobe grafts were obtained by transecting the liver on the right side of the middle hepatic vein without inflow vascular occlusion,using an ultrasonic dissector.After operation the donors were monitored in the Intensive Care Unit for about three days.Each donor was followed up for at least 6 months.RESULTS:There was no donor mortality.Major complications occurred in 14 donors(13.3%),of whom 3 received conservative treatment,8 required invasive paracentesis,and 3 required further surgery.All donors were recovered well and resumed their previous occupations.CONCLUSIONS:Donors of the right lobe face low risks.The preoperative evaluation,especially evaluation of the volume of the remnant liver,should be exact.During the operation,the patency of the remnant hepatic vasculature and bile duct must be preserved,and the extent of injury to the remnant liver should be limited as much as possible.The detection and treatment of postoperative complications should be diligently performed. | Ran, Shun Wen, Tian-Fu Yan, Lu-Nan Li, Bo Zeng, Yong Chen, Zhe-Yu Zhang, Yu Liao, Zhi-Xue Liang, Guan-Lin Li, Guo Zhang, Xian-Hua | 2009 | Hepatobiliary & Pancreatic Diseases International2009，8，6： | 8 |
| 13 | Novel Ru - K/Carbon Nanotubes Catalyst for Ammonia Synthesis显示文摘A novel ammonia synthesis catalyst, potassium-promoted ruthenium supported on carbon nanotubes, was developed. It was found that the Ru-K/carbon nanotubes catalyst had higher activity for ammonia synthesis (20.85 ml NH3/h/g-cat ) than the Ru-K/fullerenes (13.3 ml NH3/h/g-cat ) at atmospheric pressure and 623 K. The catalyst had activity even at 473 K. and had the highest activity (23.46 ml NH3/h/g-cat ) at 643 K. It was suggested that the multi-walled structure favored the electron transfer the hydrogen-storage and the hydrogen-spill which were favorable to ammonia synthesis. | Yun CAI Jing Dong LIN Hong Bo CHEN Hong Bin ZHANG Guo Dong LIN Dai Wei LIAO (State Key Lab of Physical Chemistry on Solid Surfaces. Department of Chemistry Institute of Physical Chemistry. Xiamen University, Xiamen 361005) | 2000 | Chinese Chemical Letters2000，11，4： | 8 |
| 14 | New insights into p53 functions through its target microRNAs显示文摘肿瘤 suppressor p53 小径,其改变高度与人的癌症的所有类型被联系,在主要通过它的下游的目标基因阻止肿瘤开发和前进玩 essentialrole。在最后十年, microRNA (miRNA ) 指向的 p53 的 growinglist 作为这条小径的另外的下游的播放器被识别了。这些 miRNAs 揭示了的进一步的 studiesof 他们在执行或调整 p53 activity.Here 的更复杂的规定和功能,我们考察远这样识别的 p53 miRNA 目标,并且讨论他们怎么调整 p53 压力回答,调停在 p53 之间的 thecrosstalk 和另外的发信号的小径,并且除了癌症在另外的人的疾病扩展 p53 的角色。 | Jun-Ming Liao Bo Cao XiangZhou Hua Lu | 2014 | Journal of Molecular Cell Biology2014，8，3： | 8 |
| 15 | Effects of welding wire composition and welding process on the weld metal toughness of submerged arc welded pipeline steel显示文摘The effects of alloying elements in welding wires and submerged arc welding process on the microstructures and low-temperature impact toughness of weld metals have been investigated. The results indicate that the optimal contents of alloying elements in welding wires can improve the low-temperature impact toughness of weld metals because the proeutectoid ferrite and bainite formations can be suppressed,and the fraction of acicular ferrite increases. However,the contents of alloying elements need to vary along with the welding heat input. With the increase in welding heat input,the contents of alloying elements in welding wires need to be increased accordingly. The microstructures mainly consisting of acicular ferrite can be obtained in weld metals after four-wire submerged arc welding using the wires with a low carbon content and appropriate contents of Mn,Mo,Ti-B,Cu,Ni,and RE,resulting in the high low-temperature impact toughness of weld metals. | De-liang Ren Fu-ren Xiao Peng Tian Xu Wang Bo Liao | 2009 | International Journal of Minerals,Metallurgy and Materials2009，16，1： | 7 |
| 16 | CuO/zeolite catalyzed oxidation of gaseous toluene under microwave heating显示文摘为甲苯浪费气体的处理加热的催化氧化和微波的联合进程的开发在这个工作被描述。甲苯,典型有毒的不稳定的有机化合物,通过包含催化剂与硅碳化物混合了的支持沸石的铜氧化物(CuO/zeolite ) 的一个固定的床反应房间被氧化(原文如此) ,优秀吸收微波的材料。目标化合物高效地在温度完成了由的高反应在催化剂的表面上被降级加热微波原文如此。一套试验性的参数例如微波力量,让流动和 CuO 等等的装载尺寸通风,分别地被调查。学习证明这些参数在甲苯降级上有批评影响。在最佳的状况下面, 92% 甲苯被这个联合过程移开,相应于 80%90% TOC 移动率。而且,催化剂甚至在八连续 6-h 跑以后是高度稳定的。最后,甲苯的一条假想降级小径基于从红外线的光谱学分析的煤气的层析团光谱和 Fourier 变换获得的试验性的数据被建议。 | Longli BO Jianbo LIAO Yucai ZHANG Xiaohui WAN Quan YANG | 2013 | Frontiers of Environmental Science & Engineering2013，7，3： | 7 |
| 17 | Novel Ruthenium Catalyst (K-Ru/C_(60/70)) for Ammonia Synthesis显示文摘A novel ammonia-synthesis catalyst. potassium-promoted ruthenium supported on fullerene (K-Ru/C60/70 ). was prepared and evaluated, It was found that K-Ru/C60/70 was the most active catalyst for ammonia synthesis at atmospheric pressure and 623 K compared with other support materials such as silica, activated carbon. zeolite, λ-Al2O3 and rare earth metal oxide. | Guang WEI Li Hua WANG Yi Ji LIN Jun YI Hong Bo CHEN Dai Wei LIAO (Department of Chemistry, State Key Lab of Physical Chemistry on Solid Surfaces.Institute of Physical Chemistry, Xiamen University. Xiamen 361003) | 1999 | Chinese Chemical Letters1999，10，5： | 7 |
| 18 | Predictive effects of bilirubin on response of colorectal cancer to irinotecan-based chemotherapy显示文摘AIM: To examine the predictive effects of baseline serum bilirubin levels and UDP-glucuronosyltransferase(UGT) 1A1*28 polymorphism on response of colorectal cancer to irinotecan-based chemotherapy.METHODS: The present study was based on a prospective multicenter longitudinal trial of Chinese metastatic colorectal cancer(m CRC) patients treated with irinotecan-based chemotherapy(NCT01282658). Baseline serum bilirubin levels, including total bilirubin(TBil) and unconjugated bilirubin(UBil), were measured,and genotyping of UGT1A1*28 polymorphism was performed. Receiver operating characteristic curve(ROC) analysis was used to determine cutoff values of TBil and UBil. The TBil values were categorized into > 13.0 or ≤ 13.0 groups; the UBil values were categorized into > 4.1 or ≤ 4.1 groups. Combining the cutoff values of TBil and UBil, which was recorded as Co Bil, patients were classified into three groups. The classifier's performance of UGT1A1*28 and Co Bil for predicting treatment response was evaluated by ROC analysis. Associations between response and Co Bil or UGT1A1*28 polymorphism were estimated using simple and multiple logistic regression models. RESULTS: Among the 120 m CRC patients, the serum bilirubin level was significantly different between the UGT1A1*28 wild-type and mutant genotypes. Patients with the mutant genotype had an increased likelihood of a higher TBil(P = 0.018) and a higher UBil(P = 0.014) level compared with the wild-type genotype. Patients were stratified into three groups based on Co Bil. Group 1 was patients with TBil > 13.0 and UBil > 4.1; Group 2 was patients with TBil ≤ 13.0 and UBil > 4.1; and Group 3 was patients with TBil ≤ 13.0 and UBil ≤ 4.1. Patients in Group 3 had more than a 10-fold higher likelihood of having a response in the simple(OR = 11.250; 95%CI: 2.286-55.367; P = 0.003) and multiple(OR = 16.001; 95%CI: 2.802-91.371; P = 0.002) analyses compared with the Group 1 individuals. Patients carrying the UGT1A1*28(TA)7 allele were 4-fold less likely to present with a response compared with the individuals harboring a homozygous(TA)6 genotype in the simple(OR = 0.267; 95%CI: 0.100-0.709; P = 0.008) and multiple(OR = 0.244; 95%CI: 0.088-0.678; P = 0.007) analyses. Classifier's performance of Co Bil and UGT1A1*28 were comparable.CONCLUSION: Co Bil and UGT1A1*28 are both independent biomarkers for predicting the treatment response of m CRC patients to irinotecan-based chemotherapy. After validation, Co Bil, an easily determinable index in the clinic, might be helpful in facilitating stratification of m CRC patients for individualized treatment options. | Qian-Qian Yu Hong Qiu Ming-Sheng Zhang Guang-Yuan Hu Bo Liu Liu Huang Xin Liao Qian-Xia Li Zhi-Huan Li Xiang-Lin Yuan | 2016 | World Journal of Gastroenterology2016，22，16： | 7 |
| 19 | Overactive bladder symptom score to evaluate efficacy of solifenacin for the treatment of overactive bladder symptoms显示文摘 | Liu Ming Wang Jianye Yang Yong An Ruihua Wen Jianguo Guan Zhichen Zheng Shaobin Wang Dongwen Song Bo Liao Limin Guo Hongqian Xiao Jiaquan Sun Yinghao Shen Zhoujun Kong Chuize He Dalin Huang Yiran Wang Xiaofeng Zhang Xu Li Hanzhong Huang Jian Zhao Xiaokun Zeng Puqing Song Xishuang Ye Zhangqun | 2014 | Chinese Medical Journal2014，，2： | 7 |
| 20 | The Effect of High Temperature after Anthesis on Rice Quality and Starch Granule Structure of Endosperm显示文摘To ascertain the effect mechanism of high temperature after anthesis on rice quality,the experiment was conducted with two rice lines,the heat-tolerant line 996 and heat-sensitive line 4628,with high temperature and optimal temperature in the growth chamber to investigate the effect of high temperature stress after anthesis on rice appearance quality,milling quality,cooking and eating quality and starch granule structure of endosperm. The result showed that milled rice rate,head rice rate,amylose content and gel consistency of both lines decreased under high temperature stress after anthesis,while the ratio of grain length to width,chalky rate,chalkiness,protein content increased. Under high temperature treatments,gelatinization temperature,final viscosity,set back and peak time increased,breakdown decreased,Mg content and K content increased,Mg / K ratio decreased. Under same treatment,the extent of rice quality of heat tolerant line 996 affected by high temperature was lower than that of heat sensitive line 4628. Under high temperature stress after anthesis,starch granule arranged untightly,most of starch granules existed in the form of a single starch endosperm,refractive index decreased,transparency reduced,and led to the formation of chalk. Under high temperature stress after anthesis,the increase of protein content,the decrease of Mg / K,the changes of rice RVA profile characteristics and starch granule structure of endosperm could be the main reason for the decrease of rice cooking and eating quality and appearance quality. | Zhang Guilian Liao Bin Li Bo Cai Zhihuan | 2016 | Meteorological and Environmental Research2016，7，3： | 6 |
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