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| 1 | Astragalus polysaccharide stimulates glucose uptake in L6 myotubes through AMPK activation and AS160/TBCID4 phosphorylation显示文摘 | Jian LIU Jing-fang ZHANG Jin-zhi LU De-ling ZHANG Ke LI Ke SU Jing WANG Ye-min ZHANG Nian WANG Si-tu YANG Lang BU Jing-ping OU-YANG | 2013 | Acta Pharmacologica Sinica2013，34，1： | 26 |
| 2 | Infantile hepatic hemangioendothelioma:A clinicopathologic study in a Chinese population显示文摘AIM:To investigate whether the clinicopathologic features of infantile hemangioendothelioma(IHE) of the liver in a Chinese population are similar to the features observed in other races.METHODS:The clinical data,radiological findings,histopathological changes and outcome of 12 cases of IHE diagnosed by the Department of Pathology,West China Hospital over the last 10 years were analyzed retrospectively.Immunohistochemical studies were carried out using antibodies against CD31,CD34,Factor Ⅷ,cytokeratin 8 and cytokeratin 18.RESULTS:The 12 patients were aged from fetal to 5 years(three males and nine females).The tumor was presented with different clinical manifestations,mainly as an asymptomatic,palpable,upper abdominal mass,except for the two fetuses who were detected antena-tally by ultrasound.In one patient,this presentation was accompanied by an initial severe pneumothorax.No symptoms of congestive heart failure were present and neither congenital abnormalities nor vascular tumors in the skin or other organs were found.Laboratory abnormalities included leukocytosis(40%),anemia(60%),thrombocytosis(60%),hyperbilirubinemia(16.7%),abnormal liver function(50%) and increased α-fetoprotein(80%).Based on radiological findings and gross specimens,the tumor presented as a solitary lesion or a multifocal space-occupying lesion.The tumor size ranged from 5.0 cm × 3.5 cm × 2.0 cm to 13.8 cm × 9.0 cm × 7.7 cm,and the 0.2-1.1 cm nodules were diffusely distributed within the multifocal tumor.Seven cases were surgically resected,three cases underwent biopsy and the two fetuses were aborted.Histologically,nine cases were classified as typeⅠ and three as type Ⅱ,presenting aggressive morphologic features,immature vessels,active mitosis and necrosis.An inflammatory component,predominantly eosinophilic granulocytes,sometimes obscured the nature of the tumor.Ten patients are alive after a follow-up of 1-9 years.Based on immunohistochemistry,the endothelial cells in all cases were positive for CD31,CD34 and polyclonal factor Ⅷ antigen,whereas the scattered hyperplasia bile ducts were positive for cytokeratin 8 and cytokeratin 18.CONCLUSION:The clinical manifestations of IHE are non-specific.There is no significant correlation between histological type and prognosis.The clinicopathologic features of IHE in Chinese patients may provide a clue to further evidence-based studies. | Zhang Zhang,Hui-Jiao Chen,Wen-Juan Yang,Hong Bu,Bing Wei,Xiao-Yu Long,Jing Fu,Rui Zhang,Yun-Bi Ni,Hong-Ying Zhang,Department of Pathology,West China Hospital,Sichuan University,Guoxuexiang 37,Chengdu 610041,Sichuan Province,China | 2010 | World Journal of Gastroenterology2010，16，36： | 16 |
| 3 | Serum cystatin C levels are negatively correlated with post-stroke cognitive dysfunction显示文摘Stroke is the leading cause of death and long-term disability worldwide,and cognitive impairment and dementia are major complications of ischemic stroke.Cystatin C (CysC) has been found to be a neuroprotective factor in animal studies.However,the relationship between CysC levels and cognitive dysfunction in previous studies has revealed different results.This prospective observational study investigated the correlation between serum CysC levels and post-stroke cognitive dysfunction at 3 months.Data from 638 patients were obtained from the China Antihypertensive Trial in Acute Ischemic Stroke (CATIS).Cognitive dysfunction was assessed using the Mini-Mental State Examination (MMSE) at 3 months after stroke.According to the MMSE score,308 patients (52.9%) had post-stroke cognitive dysfunction.After adjusting for potential confounding factors,the odds ratio (95% CI) of post-stroke cognitive dysfunction for the highest quartile of serum CysC levels was 0.54 (0.30–0.98),compared with the lowest quartile.The correlation between serum CysC and cognitive dysfunction was modified by renal function status.We observed a negative linear dose-response correlation between CysC and cognitive dysfunction in patients with normal renal function (Plinearity = 0.044),but not in those with abnormal renal function.Elevated serum CysC levels were correlated with a low risk of 3-month cognitive dysfunction in patients with acute ischemic stroke,especially in those with normal renal function.The current results suggest that CysC is a protective factor for post-stroke cognitive dysfunction,and could be used to treat post-stroke cognitive dysfunction.The CATIS study was approved by the Institutional Review Boards at Soochow University from China (approval No.2012-02) on December 30,2012,and was registered at ClinicalTrials.gov (identifier No.NCT01840072) on April 25,2013. | Dao-Xia Guo Zheng-Bao Zhu Chong-Ke Zhong Xiao-Qing Bu Li-Hua Chen Tan Xu Li-Bing Guo Jin-Tao Zhang Dong Li Jian-Hui Zhang Zhong Ju Chung-Shiuan Chen Jing Chen Yong-Hong Zhang Jiang He | 2020 | Neural Regeneration Research2020，15，5： | 14 |
| 4 | Molecular Typing of Brucella Suis Collected from 1960s to 2010s in China by MLVA and PFGE显示文摘Brucellosis is a bacterial anthropozoonosis usually caused by Brucella abortus, Brucella melitensis, Brucella suis and Brucella canis. Brucella suis, the causative agent of swine brucellosis, is classified into five biovars and preferentially infects different animal hosts [1] . | LI Zhen Jun CUI Bu Yun CHEN Hai CHEN Jing Diao ZHAO Hong Yan PIAO Dong Ri JIANG Hai ZHANG Li TANG Xu KE Chang Wen YAO zhen TIAN Guo Zhong | 2013 | Biomedical and Environmental Sciences2013，26，6： | 13 |
| 5 | Upconversion nano-photosensitizer targeting into mitochondria for cancer apoptosis induction and cyt c fluorescence monitoring显示文摘反应的氧种类(mitoROS ) 玩的 mitochondrial 的混乱在癌症房间 apoptosis 的一个主要角色。这里,我们设计了 core/shell-structured 有由 photosensitizer (PS ) 涂的核心合并了的做 lanthanide 的 upconversion nanoparticle (UCNP ) 的指向线粒体的基于 upconversion 的使 nano 具有感光性(TPP-UC (PS )) 稠密的硅石壳。有外部在红外线附近的激光(NIR ) 的后面的照耀,在引起为激活的基于 upconversion 的光力学的治疗(UC 太平洋夏季时间) 胀大的严肃的 mitochondrial 矩阵的线粒体的 TPP-UC (PS ) ,和细胞色素 c (cyt c ) 的动员响应增加的 mitoROS 被放大。明确地,这包含 heme cyt c 能被改变 TPP-UC (PS ) s upconversion 光信号(UCL ) 监视,它可以便于在里面为 apoptosis 研究的 cyt c 的 situ 察觉。作为概念的一个证明,我们的设计 TPP-UC (PS ) 可以为在 NIR 刺激下面控制癌症房间 apoptosis 并且为用动态 UCL 学习 apoptosis 提供重要机会,它被本地 cyt c 影响。 | Yanyan Liu Jiawen Zhang Changjing Zuo Zhen Zhang Dalong Ni Chen Zhang Jing Wang Hui Zhang Zhenwei Yao Wenbo Bu | 2016 | Nano Research2016，9，11： | 8 |
| 6 | 尺度解析模拟在液力偶合器、液力缓速器和液力变矩器中的应用(英文)显示文摘目的:针对流体机械数值模拟过程中雷诺时均应力(RANS)方法占据主导地位但预测精度较低且缺乏对流场信息准确描述的现状,提出应用尺度解析模拟(SRS)方法来改进性能的预测精度以及加深对流动结构的理解。创新点:1.利用SRS方法,降低RANS湍流模型的选择困难,实现性能精准预测;2.建立全流道网格计算模型,充分展现单流道间瞬时流动信息的差异。方法:1.通过较少的网格划分及周期计算,对具有简单循环圆和平面叶片的液力偶合器进行计算,并与试验数据进行对比,初步筛选出较为适合的湍流模型(图6),进而在模型更为复杂、流动更加多变的液力缓速器和液力变矩器性能预测中进行验证(图15和21);2.通过对复杂的瞬态流动现象的清晰捕捉,深入展示3种液力元件的内部流动机理(图9、10、16、17、22和23),并评估SRS方法相较RANS方法在流动结构描述方面的先进性(图7和8)。结论:1.在液力偶合器、液力缓速器和液力变矩器等液力流体机械的计算流体动力学(CFD)模拟中,SRS方法可以提高性能预测精度并提供更为细致的流场信息;2. SRS方法中的混合RANS/LES(大涡模拟)模型在液力元件流场计算中的预测准确度、流场结构描述及计算成本等方面表现出色,尤其是BSLSBESDSL模型值得重点关注和发展;3.为了进一步验证SRS方法的实用性,可以在模拟中考虑工作介质物理属性的影响,细化网格并对气液两相流动及边界层流动进行详细计算。 | Chun-bao LIU Jing LI Wei-yang BU Zhi-xuan XU Dong XU Wen-xing MA | 2018 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2018，19，12： | 7 |
| 7 | Fast acquisition of 3D images in a modified optical microscope based on integral imaging显示文摘This paper introduces a new technique of fast acquiring 3D information in microscope based on integral imaging. Experimental results prove that the proposed method has advantageous properties including simple configuration, no requirement of coherent light source and real-time 3D imaging information acquisition. This technique has an important prospect on optical microscopy and 3D display. | DAI ZhiHua WANG JinGang ZHAO Xing YANG Yong BU Jing YUAN XiaoCong | 2012 | Science China(Technological Sciences)2012，55，4： | 7 |
| 8 | Three-dimensional Culture of Human Airway Epithelium in Matrigel for Evaluation of Human Rhinovirus C and Bocavirus Infections显示文摘Objective Newly identified human rhinovirus C(HRV-C) and human bocavirus(HBoV) cannot propagate in vitro in traditional cell culture models; thus obtaining knowledge about these viruses and developing related vaccines are difficult. Therefore, it is necessary to develop a novel platform for the propagation of these types of viruses. Methods A platform for culturing human airway epithelia in a three-dimensional(3 D) pattern using Matrigel as scaffold was developed. The features of 3 D culture were identified by immunochemical staining and transmission electron microscopy. Nucleic acid levels of HRV-C and HBoV in 3 D cells at designated time points were quantitated by real-time polymerase chain reaction(PCR). Levels of cytokines, whose secretion was induced by the viruses, were measured by ELISA. Results Properties of bronchial-like tissues, such as the expression of biomarkers CK5, ZO-1, and PCK, and the development of cilium-like protuberances indicative of the human respiration tract, were observed in 3 D-cultured human airway epithelial(HAE) cultures, but not in monolayer-cultured cells. Nucleic acid levels of HRV-C and HBoV and levels of virus-induced cytokines were also measured using the 3 D culture system. Conclusion Our data provide a preliminary indication that the 3 D culture model of primary epithelia using a Matrigel scaffold in vitro can be used to propagate HRV-C and HBoV. | CHEN Ya Xiong XIE Guang Cheng PAN Dong DU Ya Rong PANG Li Li SONG Jing Dong DUAN Zhao Jun HU Bu Rong | 2018 | Biomedical and Environmental Sciences2018，31，2： | 6 |
| 9 | DeST 3.0:A new-generation building performance simulation platform显示文摘Buildings contribute to almost 30%of total energy consumption worldwide.Developing building energy modeling programs is of great significance for lifecycle building performance assessment and optimization.Advances in novel building technologies,the requirements of high-performance computation,and the demands for multi-objective models have brought new challenges for building energy modeling software and platforms.To meet the increasing simulation demands,DeST 3.0,a new-generation building performance simulation platform,was developed and released.The structure of DeST 3.0 incorporates four simulation engines,including building analysis and simulation(BAS)engine,HVAC system engine,combined plant simulation(CPS)engine,and energy system(ES)engine,connected by air loop and water loop balancing iterations.DeST 3.0 offers numerous new simulation features,such as advanced simulation modules for building envelopes,occupant behavior and energy systems,cross-platform and compatible simulation kernel,FMI/FMU-based co-simulation functionalities,and high-performance parallel simulation architecture.DeST 3.0 has been thoroughly evaluated and validated using code verification,inter-program comparison,and case-study calibration.DeST 3.0 has been applied in various aspects throughout the building lifecycle,supporting building design,operation,retrofit analysis,code appliance,technology adaptability evaluation as well as research and education.The new generation building simulation platform DeST 3.0 provides an efficient tool and comprehensive simulation platform for lifecycle building performance analysis and optimization. | Da Yan Xin Zhou Jingjing An Xuyuan Kang Fan Bu Youming Chen Yiqun Pan Yan Gao Qunli Zhang Hui Zhou Kuining Qiu Jing Liu Yan Liu Honglian Li Lei Zhang Hong Dong Lixin Sun Song Pan Xiang Zhou Zhe Tian Wenjie Zhang Ruhong Wu Hongsan Sun Yu Huang Xiaohong Su Yongwei Zhang Rui Shen Diankun Chen Guangyuan Wei Yixing Chen Jinqing Peng | 2022 | Building Simulation2022，15，11： | 5 |
| 10 | Anatomical variation of infra-pyloric artery origination: A prospective multicenter observational study (IPA-Origin)显示文摘Objective: Infra-pyloric artery(IPA) is an important anatomical landmark in treatment of gastric cancer and is the key vessel for pylorus-preserving gastrectomy and subgroup of infra-pyloric lymph nodes. However, its anatomical variation is not thoroughly understood. Our study aimed to clarify the origination of the IPA.Methods: We did this prospective, multicenter, open-label, observational study at gastric surgery departments of34 hospitals in China. Gastric cancer patients aged 18 years or older and scheduled to undergo elective total or distal gastrectomy were assigned. During the surgery, IPA dissecting and exposing the origination point with photographs or video clips were required. The primary outcome was the origination of the IPA. Analysis of variance, χ~2 tests and Fisher's tests were used to analyze the differences between groups. The study is registered at Clinicaltrials.gov(No. NCT03071237).Results: Between May 8 and July 31, 2017, 429 patients were assigned for the study, and 419(97.7%) patients had the IPA dissected and recorded through photograph or video and were included in the primary outcome analysis. The median age was 62 years old, and 73.7% were male. Among the patients, 78.5% received laparoscopic surgery. Single IPA origination was identified in 398(95.0%) patients, including gastroduodenal artery(GDA) in154(36.8%) patients, anterior superior pancreaticoduodenal artery(ASPDA) in 130(31.0%) patients, and right gastroepiploic artery(RGEA) in 114(27.2%) patients. Fifteen(3.6%) patients were identified with multiple IPA and 6(1.4%) patients were identified as IPA absence. The differences in the distribution of surgical approach(P=0.003) and geographic area(P=0.030) were statistically significant. No difference was shown in sex, age,gastrectomy type, tumor location, and clinical T, N and M stage.Conclusions: Our study found that the IPA originates from GDA, ASPDA and RGEA in similar proportions.Laparoscopic surgery may be more helpful in dissection of the IPA than open surgery. | Rulin Miao Jianjun Qu Zhengrong Li Daguang Wang Jiang Yu Weidong Zang Yong Li Fenglin Liu Jian Zhang Wu Song Kai Ye Su Yan Wei Wang Shuangyi Ren Lu Zang Changqing Jing Li Zhang Kuan Wang Weihua Fu Lin Fan Bin Liang Gang Zhao Jun Cai Li Yang Jiaming Zhu Jun You Kun Yang Qingxing Huang Zhaojian Niu Ning Ning Xingfeng Qiu Gang Ji Feng Liang Hua Huang Chao Gao Fei Shan Shuangxi Li Yongning Jia Lianhai Zhang Xiangji Ying Yan Zhang Zhaode Bu Xiangqian Su Gang Zhao Ziyu Li Jiafu Ji | 2018 | Chinese Journal of Cancer Research2018，30，5： | 5 |
| 11 | Postoperative chemotherapy with S-1 plus oxaliplatin versus S-1alone in locally advanced gastric cancer(RESCUE-GC study): a protocol for a phase Ⅲ randomized controlled trial显示文摘Background:The ACTS-GC study had shown postoperative adjuvant therapy with S-1 improved survival of patients with locally advanced gastric cancer.Addition of oxaliplatin to S-1 is considered to be acceptable as one of the treatment options for gastric cancer patients after radical gastrectomy with D2 lymph node excision.Methods:We have commenced a randomized phase III trial in December 2016 to evaluate S-1 plus oxaliplatin compared with S-1 alone in the adjuvant setting for locally advanced gastric cancer.A total of 564 patients will be accrued from 13 Chinese institutions in two years.The primary endpoint is 3-year relapse-free survival.The secondary endpoints are 5-year overall survival,proportion of patients who complete the postoperative chemotherapy and incidence of adverse events.Ethic and dissemination:The trial has been approved by the institutional review board of each participating institution and it was activated on December,2016.The enrollment will be finished in December,2018.Patient’s follow-up will be ended until December,2023.Trial registration:Clinical Trials.gov,identifier:NCT02867839.Registered on August 4,2016. | Xiang Hu Lin Chen Yian Du Biao Fan Zhaode Bu Xin Wang Yingjiang Ye Zhongtao Zhang Gang Xiao Fei Li Qingsi He Guoli Li Xian Shen Bin Xiong Liming Zhu Jiwei Liui Lian Liu Tao Wu Jing Zhou Jun Zhang Gang Zhao Xulin Wang Pin Liang Xinxin Wang Yan Zhang Xiaojiang Wu Ji Zhang Xin Ji Xianglong Zong Tao Fu Ziyu Jia Jiafu Ji | 2017 | Chinese Journal of Cancer Research2017，29，2： | 5 |
| 12 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 13 | The Role of HBx Gene Mutations in PLA2R Positive Hepatitis-B-associated Membranous Nephropathy显示文摘China is a higher-intermediate hepatitis B virus(HBV)endemicity country,and HBV is among the most important infectious diseases[1,2].Hepatitis-Bassociated glomerulonephritis(HBV-GN)is also one of the main forms of secondary kidney diseases seen in China[3].The main pathological type is hepatitis-Bassociated membranous nephropathy(HBV-MN).In the recent years,it has been found that human renal podocyte membrane M-type phospholipase 2 receptor(PLA2R)is the main autoantigen in idiopathic membranous nephropathy(IMN)[4].At present,it is found that PLA2 R and its antibodies are. | DONG Hui XU Yan XU Ting SUN Jing Yi BU Quan Dong WANG Yan Fei CHE Lin ZHAO Long JIANG Wei | 2020 | Biomedical and Environmental Sciences2020，33，4： | 3 |
| 14 | Reproducibility of the Nottingham modification of the Scarff- Bloom-Richardson histological grading system and the complementary value of Ki-67 to this system显示文摘背景为侵略乳癌(IBC ) 的组织学的分级系统由世界健康组织采用了的 Scarff-Bloom-Richardson (NSBR ) 的诺丁汉修正的重制度() 以前没在中国医院里被学习。增长标记, Ki-67,广泛地在检测 IBC 被使用了。这研究的目的是在中国病理学家和 Ki-67 独立地带给 100 个 IBC 盒子到四个一般病理学家分级的这 system.Methods 的互补价值之中估计 NSBR 系统的重制度,它被专家以前在胸病理分级。在四个一般病理学家之中的 interobserver 重制度和在他们和专家中的每之间的 pairwise 重制度被估计。把索引(Ki-67LI ) 标记的 Ki-67 被 immunohistochemistry 决定,并且它与组织学的等级和幸存的关联是关于 interobserver 重制度的 determined.Results,分级的 NSBR 是相当可再现的(kappa=0.34 ) ;至于分级的 NSBR 的部件,同意为小管形成(kappa=0.46 ) 是最好的,为有丝分裂的计数(kappa=0.28 ) 为原子多形性(kappa=0.42 ) 中间、最差。以 pairwise 重制度,同意对公正与分级的 NSBR (kappa=0.30-0.69 ) 和原子多形性(kappa=0.28-0.69 ) 实质,对中等到为小管形成(kappa=0.51-0.78 ) 实质、细微实质因为有丝分裂的计数(kappa=0.19-0.71 ).There 是为等级的典型 Ki-67LI 范围 1,2 和 3 个肿瘤。Univariate 分析证明 Ki-67 能把等级 2 病人划分成二不同预示的亚群。有否定淋巴节点的等级 2 病人的 Multivariate 分析证明 Ki-67 是为全面 survival.Conclusions 的一个独立预言者由一般病理学家分级的重制度能被提高。在胸病理的专门化为为 IBC 的精确分级和治疗是必要的。与证明预示的意义, Ki-67 把互补价值加到 NSBR 系统。 | ZHANG Rui CHEN Hui-jiao WEI Bing ZHANG Hong-ying PANG Zong-guo ZHU Hong ZHANG Zhang FU Jing BU Hong | 2010 | Chinese Medical Journal2010，，15： | 3 |
| 15 | Correlates of Condom-use Self-efficacy on the EPPM-based Integrated Model among Chinese College Students显示文摘Objective To explore the predictors of condom-use self-efficacy in Chinese college students according to the extended parallel process model(EPPM)-based integrated model.Methods A total of 3,081 college students were anonymously surveyed through self-administered questionnaires in Guangzhou and Harbin,China.A structural equation model was applied to assess the integrated model.Results Among the participants,1,387(46.7%)were male,1,586(53.3%)were female,and the average age was 18.6 years.The final integrated model was acceptable.Apart from the direct effect(r=0.23),perceived severity had two indirect effects on condom-use self-efficacy through the attitude to HIV education(r=0.40)and intention to engage in premarital sex(r=-0.16),respectively.However,the perceived susceptibility mediated through the intention to engage in premarital sex(intent-to-premarital-sex)had a poor indirect impact on condom-use self-efficacy(total effect was-0.06).Furthermore,attitude toward HIV health education(r=0.49)and intent-to-premarital-sex(r=-0.31)had a strong direct effect on condom-use self-efficacy.In addition,male students perceived higher susceptibility,stronger intent-to-premarital-sex,and lower condom-use self-efficacy than female students.Conclusion The integrated model may be used to assess the determinants of condom-use self-efficacy among Chinese college students.Future research should focus on raising the severity perception,HIV-risk-reduction motivation,and the premarital abstinence intention among college students.Furthermore,considering the gender differences observed in the present survey,single-sex HIV education is required in school-based HIV/sex intervention. | JIN Shan Shan BU Kai CHEN Fang Fang XU Hui Fang LI Yi ZHAO Dong Hui XU Fang LI Jing Yan HAN Meng Jie WANG Ning WANG Lu | 2017 | Biomedical and Environmental Sciences2017，30，2： | 3 |
| 16 | Cross-lenticular lens array for full parallax 3-D display with crosstalk reduction显示文摘As a 3-D display technology,stereoscopic imaging with lenticular lens sheet can only offer viewers the horizontal parallax.To reconstruct the 3-D image with parallax in both horizontal and vertical directions,the full parallax technique with micro-lens array was proposed.But due to the fabrication constraints and cost concerns of the micro-lens array,application of the full parallax technique is restricted in practice.In this paper we revisited the lenticular sheet method and cross-lenticular lens array formed by two lenticular sheets overlapped orthogonally.By analyzing the optical properties of this cross-lenticular lens array,we found that it has reasonable imaging qualities as a conventional micro-lens array.Besides,due to the poor optical property of the outskirt area of the cross-lenticular lens,the cross-lenticular lens array has better crosstalk suppression capability than the conventional one.Based on the analysis,in this paper,we used the proposed lens array to reconstruct a 3-D image and verified its practicability.The cross-lenticular lens array was found feasible to take the full parallax technique into commercial applications,with comparable advantages in terms of low-cost and easy fabrication over a large area. | XIE HongBin ZHAO Xing YANG Yong BU Jing FANG ZhiLiang YUAN XiaoCong | 2012 | Science China(Technological Sciences)2012，55，3： | 3 |
| 17 | Effects of drought stress on the photosynthetic physiological parameters of Populus 3 euramericana ‘‘Neva''显示文摘Populus 9 euramericana ‘‘Neva'' is the main poplar species in China, where drought stress is becoming extremely urgent. We carried out this research to study the effects of drought stress on the photosynthesis of Populus 9 euramericana ‘‘Neva''. Drought stress was induced by 58–62%(light), 48–52%(moderate), and 38–42%(severe) relative soil moisture content(RSMC). The effects of drought stress on photosynthetic rate, chlorophyll fluorescence parameters, and other related physiological parameters were investigated during treatment. Net photosynthetic rate(PN), and stomatal conductance decreased significantly and intercellular CO_2 concentration initially increased and then declined, whereas the stomatal limitation factors showed opposite trends in the light under moderate drought stress. Photosystem II(PSII) maximum photochemical efficiency, actual photochemical efficiency,and photochemical quenching decreased gradually under drought stress, whereas nonphotochemical quenching initially increased and then declined. Superoxide dismutase,peroxidase, and catalase activities initially increased and then decreased as RSMC was reduced, whereas malondialdehyde(MDA) content and relative electric conductivity(REC) increased gradually. These results suggest that stomatal factors accounted for the decline in PNunder light and moderate drought stress, whereas leaf PNdecreased mainly due to non-stomatal factors under severe drought stress. PSII was damaged; thus, photosynthetic electron transfer was restricted, indicating that heat dissipation is important for the light protection mechanism of plants.Antioxidant enzymes increased at the beginning of treatment, and the increased MDA and REC led to cell membrane damage. These results suggest that poplar seedlings stabilized their photosynthetic apparatus by reducing the light trapping ability under light and moderate drought stress conditions. This helped dissipate heat and enhance antioxidant enzyme activity. Stomatal factors accounted for the decline in P_N, whereas damage to PSII and antioxidant enzymes under severe drought stress suggested that the decline in P_N was caused by non-stomatal restrictive factors. | Guoting Liang Jianwen Bu Shuyong Zhang Guo Jing Guangcan Zhang Xia Liu | 2019 | Journal of Forestry Research2019，30，2： | 3 |
| 18 | Comparison of visual quality in cataract patients with low astigmatism after ART2 or ReSTOR intraocular lens implantation显示文摘AIM: To compare visual quality in cataract patients with low corneal astigmatism who underwent intraocular lens(IOL) implantation, and evaluate effects of low levels of astigmatism on visual outcomes in multifocal pseudophakic eyes.METHODS: This retrospective review of clinical records comprised patients with preoperative regular corneal astigmatism of 0.75-1.0 diopters(D) with-the-rule or 0.5-0.75 D against-the-rule who had uneventful cataract surgery and AcrySof IQ ReSTOR Toric-2 IOL(ART2) or AcrySof IQ ReSTOR IOL(ReSTOR) implantation. Retrospective data collection included postoperative ART2 axis rotation, uncorrected astigmatism, uncorrected entire visual acuities, distance corrected entire visual acuities, average modulation transfer function(aMTF), Strehl ratio(SR), spectacle independence, and patient satisfaction between groups.RESULTS: Mean ART2 axis rotation was 3.12°±0.70°. No secondary surgery was required to realign IOL axis. Residual astigmatism values were-0.18±0.07 D and-0.91±0.25 D in groups ART2 and ReSTOR(P<0.05). Three months postoperatively, the mean uncorrected distant, intermediate, and near visual acuities of group A were 0.01±0.05, 0.05±0.07, 0.02±0.07 logMAR, respectively; these were better than those of group R, which were 0.08±0.06, 0.15±0.12, and 0.09±0.08 logMAR, respectively(P<0.05). aMTF, SR, and spectacle independence rates were not significantly different. All patients were satisfied with postoperative results.CONCLUSION: ART2 is more suitable than ReSTOR for cataract patients with regular corneal astigmatism 0.75-1.0 D with-the-rule or 0.5-0.75 D against-the-rule. | Jing Hao Liang-Zhang Tan Lin Li Shao-Chong Bu Xin-Jun Ren Fang Tian Hong Zhang | 2019 | International Journal of Ophthalmology(English edition)2019，12，3： | 3 |
| 19 | Role of autoantibodies against the linker subdomains of envoplakin and periplakin in the pathogenesis of paraneoplastic pemphigus显示文摘背景对多重表皮的蛋白质的自身抗体的存在是在 paraneoplastic 天疱疮(PNP ) 的一个重要特征。传播 anti-desmoglein 3 自身抗体,在天疱疮 vulgaris (PV ) 的主要病原的自身抗体,在 PNP 被证明病原。因为 PNP 和 PV 之间的许多临床的差别,我们在 PNP 的致病关于另外的自身抗体的参与推测。Envoplakin (EPL ) 和 periplakin (PPL ) 被大多数 PNP 认出干枯。他们的连接器子域为我们描绘了的中间的 filaments.Methods 的协会高度相应、必要对在 PNP 病人由连接酶的 immunosorbent 试金(ELISA ) 和 immunofluorence 的 sera 和他们的联系肿瘤的 EPL 和 PPL 的连接器子域的自身抗体。我们也从 PNP sera 对 EPL 和 PPL 把净化的自身抗体用于有教养的人的表皮的 keratinocytes ( HEK ),到把房间房间 adhesion.Results 自身抗体的变化与 EPL 和 PPL 作比较被 ELISA 在大多数 PNP 病人检测,并且在肿瘤的移动以后的这些自身抗体的减少粗略地比得上临床的症状的改进。从 PNP 病人的有教养的肿瘤房间分泌了这些自身抗体。为 EPL 和 PPL 的特定的免疫球蛋白受体从 PNP 在肿瘤在 B 淋巴细胞上被发现。而且,从 PNP 净化了 anti-EPL 和 anti-PPL 自身抗体干枯能够分裂对 EPL 和 PPL 的有教养的人的表皮的 keratinocytes.Conclusion 自身抗体可能也在 PNP 是病原的。 | LI Jing BU Ding-fang HUANG Yong-chu ZHU Xue-jun | 2009 | Chinese Medical Journal2009，，5： | 3 |
| 20 | Single-particle trapping and dynamic manipulation with holographic optical surface-wave tweezers显示文摘Optical surface waves have widely been used in optical tweezers systems for trapping particles sized from the nanoto microscale,with specific importance and needs in applications of super-resolved detection and imaging if a single particle can be trapped and manipulated accurately.However,it is difficult to achieve such trapping with high precision in conventional optical surface-wave tweezers.Here,we propose and experimentally demonstrate a new method to accurately trap and dynamically manipulate a single particle or a desired number of particles in holographic optical surface-wave tweezers.By tailoring the optical potential wells formed by surface waves,we achieved trapping of the targeted single particle while pushing away all surrounding particles and further dynamically controlling the particle by a holographic tweezers beam.We also prove that different particle samples,including gold particles and biological cells,can be applied in our system.This method can be used for different-type optical surface-wave tweezers,with significant potential applications in single-particle spectroscopy,particle sorting,nano-assembly,and others. | XI XIE XIANYOU WANG CHANGJUN MIN HAIXIANG MA YUNQI YUAN ZHANGYU ZHOU YUQUAN ZHANG JING BU XIAOCONG YUAN | 2022 | Photonics Research2022，10，1： | 3 |
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