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| 1 | Mouse macrophage specific knockout of SIRT1 influences macrophage polarization and promotes angiotensin Ⅱ-induced abdominal aortic aneurysm formation显示文摘Abdominal aortic aneurysm(AAA) is a vascular degenerative disease. Macrophage polarization and the balance between classically activated macrophages(M1) and alternatively activated macrophages(M2)are crucial for AAA pathogenesis. The present study aims to investigate the roles of macrophage SIRT1 in AAA formation and macrophage polarization. We found that in mouse peritoneal macrophages, SIRT1 expression was decreased after M1 stimulation, but was enhanced after M2 stimulation. Results from SIRT1^(flox/flox) mice and macrophage specific SIRT1 knockout mice with treatment of angiotensin II(Ang II)for 4 weeks showed that macrophage specific deficiency of SIRT1 increased the incidence of AAA and exacerbated the severity, including more severe aneurysm types, enlarged diameter of the aneurysm and increased degradation of elastin. In mouse aortas, SIRT1 deficiency increased the proinflammatory M1 molecule inducible nitric oxide synthase(i NOS), and decreased M2 molecules such as arginase 1(Arg1) and mannose receptor(MR). Furthermore, in peritoneal macrophages, SIRT1 deficiency increased the expression of M1 inflammatory molecules, but decreased the expression of M2 molecules. Overexpression of SIRT1 had the opposite effects. Thus, macrophage specific knockout of SIRT1 influences macrophage polarization and accelerates Ang II-induced AAA formation. | Zhuqin Zhang Jing Xu Yue Liu Tingting Wang Jianfei Pei Liqin Cheng Delong Hao Xiang Zhao Hou-Zao Chen De-Pei Liu | 2018 | Journal of Genetics and Genomics2018，45，1： | 15 |
| 2 | Synergistic defensive mechanism of phytochelatins and antioxidative enzymes in Brassica chinensis L. against Cd stress显示文摘Brassica chinensis L. was chosen and exposed to different concentrations of Cd exposure to evaluate its Cd-accumulating capacity and its potential cellular defensive mechanisms. Cd accumulation in the shoots and roots of B. chinensis was up to 1348.3±461.8 and 3761.0±795.0 mg per killogram of dry weight, respectively, under 200 μmol/L of Cd exposure. Increasing Cd accumulation in the plant was accompanied by rapid accumulation of phytochelatins (PCs), and the sequestration of Cd by PCs provided a primary cellular mechanism for Cd detoxification and tolerance of B. chinensis. Furthermore, malondialdehyde formation, hydrogen peroxide content and antioxidative enzyme activities such as superoxide dismutase, catalase, guaiacol peroxidase and ascorbate peroxidase were observed in the shoots of Cd-stressed B. chinensis. Increasing enzyme activities in response to concentrations of 5 to 50 μmol/L Cd showed an efficient defense against oxidative stress, suggesting that the antioxidative system was a secondary defensive mechanism. These resulted in reduced free Cd damage and enhanced Cd accumulation and tolerance. Glutathione plays a pivotal role in these two detoxification pathways. In general, these results suggested that PCs and the antioxidative system are synergistic in combatting Cd-induced oxidative stress and that they play important roles in Cd detoxification of B. chinensis, and also give a deep understanding of the natural defensive mechanisms in plants under heavy metal stress. | CHEN LiQin GUO YiFei YANG LiMin WANG QiuQuan | 2008 | Chinese Science Bulletin2008，53，10： | 8 |
| 3 | Cellulose nanofiber separator for suppressing shuttle effect and Li dendrite formation in lithium-sulfur batteries显示文摘Lithium-sulfur battery(LSB) has high energy density but is limited by the polysulfides shuttle and dendrite growth during cycling. Herein, a free-standing cellulose nanofiber(CNF) separator is designed and fabricated in isopropanol/water suspension through vacuum filtration progress. CNFs with abundant polar oxygen-containing functional groups can chemically immobilize the polysulfides, and suppress the formation of the dendrites by controlling the surface morphology of the SEI on lithium metal in LSB. The isopropanol content in a suspension can fine-tune the pore structure of the membrane to achieve optimal electrochemical performance. The prepared separator displays integrated advantages of an ultrathin thickness(19 μm), lightweight(0.87 mg cm^(-2)), extremely high porosity(98.05%), and decent electrolyte affinity. As a result, the discharge capacity of the LSB with CNF separator at the first and 100 th cycle is 1.4 and 1.3 times that of PP separator, respectively. Our research provides an environmentalfriendly and facile strategy for the preparation of multifunctional separators for LSBs. | Jingxue Li Liqin Dai Zhefan Wang Hao Wang Lijing Xie Jingpeng Chen Chong Yan Hong Yuan Hongliang Wang Chengmeng Chen | 2022 | Journal of Energy Chemistry2022，31，4： | 4 |
| 4 | Forensic investigation of 23 autosomal STRs and application in Han and Mongolia ethnic groups显示文摘A forensic validation study of the Early Access HuaxiaTM Platinum Polymerase Chain Reaction (PCR) kit was completed to document the performance capabilities and limitations.The genotyping of DNA samples was consistent across a large range of template DNA concentrations,with complete profiles obtained at 0.125 ng;however,no more than 2 mm× 1.2 mm punches of samples would be recommended for direct amplification.The size precision and accuracy test revealed the genotyping ability;while consistent results were obtained when comparing the kit with other commercially available systems.In addition,the whole PCR amplification can finish within approximately 45 min,making the system suitable for fastdetection.However,only partial profiles may be obtained with challenging samples,including DNA stored on Foam-Tipped Applicators (FTA) cards or some case samples.For the forensic application in ethnic groups,a total of 282 and 229 alleles were obtained in Han and Mongolia,respectively.Since the 23 short tandem repeats were independent from each other,the cumulative power of exclusion in duos was 0.999999157188 and the cumulative power of exclusion in trios was 0.999999999859 in the Han group while the cumulative power of exclusion in duos (CPEduo) was 0.999 998 848 26 and cumulative power of exclusion in trios (CPEtrio) was 0.999 999 999 79 in the Mongolia group.And good internal consistency was found between the two investigated groups and the Sichuan Han,Hui,Tibetan and Uygur according to available reference data. | Xiang Sheng Yali Wang Jiashuo Zhang Liqin Chen Yuan Lin Zhenmin Zhao Chengtao Li Suhua Zhang | 2018 | Forensic Sciences Research2018，3，2： | 4 |
| 5 | Research advances in forensic diatom testing显示文摘In forensic practice,it is difficult to determine whether a dead body in the water resulted from drowning or from disposal after death.Diatom testing is currently an important supporting technique for the determination of death by drowning and of drowning sites,even though it is a time-consuming and laborious task.This article reviews the development of diatom testing over the decades and discusses a new method for the potential application of deep learning in diatom testing. | Yuanyuan Zhou Yongjie Cao Jiao Huang Kaifei Deng Kaijun Ma Tianye Zhang Liqin Chen Ji Zhang Ping Huang | 2020 | Forensic Sciences Research2020，5，2： | 3 |
| 6 | Nontrivial coupling of light into a defect:the interplay of nonlinearity and topology显示文摘The flourishing of topological photonics in the last decade was achieved mainly due to developments in linear topological photonic structures.However,when nonlinearity is introduced,many intriguing questions arise.For example,are there universal fingerprints of the underlying topology when modes are coupled by nonlinearity,and what can happen to topological invariants during nonlinear propagation?To explore these questions,we experimentally demonstrate nonlinearity-induced coupling of light into topologically protected edge states using a photonic platform and develop a general theoretical framework for interpreting the mode-coupling dynamics in nonlinear topological systems.Performed on laser-written photonic Su-Schrieffer-Heeger lattices,our experiments show the nonlinear coupling of light into a nontrivial edge or interface defect channel that is otherwise not permissible due to topological protection.Our theory explains all the observations well.Furthermore,we introduce the concepts of inherited and emergent nonlinear topological phenomena as well as a protocol capable of revealing the interplay of nonlinearity and topology.These concepts are applicable to other nonlinear topological systems,both in higher dimensions and beyond our photonic platform. | Shiqi Xia Dario Jukic Nan Wang Daria Smirnova Lev Smirnov Liqin Tang Daohong Song Alexander Szameit Daniel Leykam Jingjun Xu Zhigang Chen Hrvoje Buljan | 2020 | Light(Science & Applications)2020，9，1： | 3 |
| 7 | A regional ionospheric TEC mapping technique over China and adjacent areas: GNSS data processing and DINEOF analysis显示文摘A technique is developed to derive two-dimensional maps of total electron content(TEC) over China and adjacent areas using Global Navigation Satellite System(GNSS) data from the Crustal Movement Observation Network of China(CMONOC) and the International Global Navigation Satellite System Service(IGS). A revised self-calibration of pseudo-range errors(SCORE) algorithm is used to derive the TEC and to determine the Differential Code Biases(DCBs) simultaneously. The accuracy and validity of this technique is verified in two ways. Firstly, the estimated TEC is compared with the results derived using DCBs from Center for Orbit Determination of Europe(CODE) under different solar activity conditions and seasons; secondly, sample TEC along the receiver-to-satellite ray paths are simulated by Ne Quick model and are reprocessed by this TEC derivation technique to make the accuracy test. Two-dimensional maps of vertical TEC of ionospheric pierce points(IPPs) are obtained accordingly with a time resolution of 30 s. The data interpolating empirical orthogonal functions(DINEOF) technique is then used to make the extrapolation for the unknown or missing data points. The optimal EOF modes for data reconstruction are specified via cross-validation method. The regional TEC distribution over China and adjacent areas is scaled into grid size of 1? × 1? for each 5 min, which can well reflect the characteristic of large-scale regional variations and temporal evolution as well as the small-scale local features of ionosphere. | A Ercha HUANG WenGeng LIU SiQing SHI LiQin GONG JianCun CHEN YanHong SHEN Hua | 2015 | Science China(Information Sciences)2015，58，10： | 3 |
| 8 | Toll-like receptor 5 agonist CBLB502 induces radioprotective effects in vitro显示文摘从沙门氏菌 flagellin 导出的 CBLB502 是像使用费的受体的新奇收缩筋 5 (TLR5 ) 。CBLB502 能与低毒性和 immunogenicity 在整个身体的照耀期间从官方补给、造血的症候群在老鼠和首领上施加高避免受辐射影响的功效,这被显示出。然而,没有有效系统被用来在 vitro 对照耀和相关机制调查 CBLB502 的保护的效果。在这研究,我们在组成地表示人的 TLR5 和 NF-B-dependent 酶的 HEK293-N-T 房间调查了 CBLB502 的避免受辐射影响的性质。HEK293-N-T 房间在 60 公司 -- 光线照耀。在照耀以后,房间生存能力是即时的由使用即时房间分析系统为 4 是天。我们发现 CBLB502 能够高效地维持照耀的 HEK293-N-T 房间的幸存率。然后, apoptotic 房间死亡和房间周期被流动 cytometry 检测。结果证明那个 CBLB502 预告的处理能减少 apoptosis 并且以一种剂量依赖者方式从 G2 阶段拘捕支持照耀的 HEK293-N-T 房间的恢复。我们的数据显示 CBLB502 经由 anti-apoptosis 在 vitro 有直接避免受辐射影响的效果并且支持房间周期恢复。这里开发的方法能是一在 vitro 有效屏蔽象 CBLB502 一样的另外的 TLR5 目标 radioprotectants 的系统。 | Tong Shi Liqin Li Guochao Zhou Chen Wang Xuejun Chen Ruihua Zhang Jianfu Xu Xiaojing Lu Hui Jiang Jisheng Chen | 2017 | Acta Biochimica et Biophysica Sinica2017，49，6： | 2 |
| 9 | Two Ultraviolet Radiation Datasets that Cover China显示文摘Ultraviolet(UV) radiation has significant effects on ecosystems, environments, and human health, as well as atmospheric processes and climate change. Two ultraviolet radiation datasets are described in this paper. One contains hourly observations of UV radiation measured at 40 Chinese Ecosystem Research Network stations from 2005 to 2015. CUV3 broadband radiometers were used to observe the UV radiation, with an accuracy of 5%, which meets the World Meteorology Organization's measurement standards. The extremum method was used to control the quality of the measured datasets. The other dataset contains daily cumulative UV radiation estimates that were calculated using an all-sky estimation model combined with a hybrid model. The reconstructed daily UV radiation data span from 1961 to 2014. The mean absolute bias error and root-mean-square error are smaller than 30% at most stations, and most of the mean bias error values are negative, which indicates underestimation of the UV radiation intensity. These datasets can improve our basic knowledge of the spatial and temporal variations in UV radiation. Additionally, these datasets can be used in studies of potential ozone formation and atmospheric oxidation, as well as simulations of ecological processes. | Hui LIU Bo HU Yuesi WANG Guangren LIU Liqin TANG Dongsheng JI Yongfei BAI Weikai BAO Xin CHEN Yunming CHEN Weixin DING Xiaozeng HAN Fei HE Hui HUANG Zhenying HUANG Xinrong LI Yan LI Wenzhao LIU Luxiang LIN Zhu OUYANG Boqiang QIN Weijun SHEN Yanjun SHEN Hongxin SU Changchun SONG Bo SUN Song SUN Anzhi WANG Genxu WANG Huimin WANG Silong WANG Youshao WANG Wenxue WEI Ping XIE Zongqiang XIE Xiaoyuan YAN Fanjiang ZENG Fawei ZHANG Yangjian ZHANG Yiping ZHANG Chengyi ZHAO Wenzhi ZHAO Xueyong ZHAO Guoyi ZHOU Bo ZHU | 2017 | Advances in Atmospheric Sciences2017，34，7： | 2 |
| 10 | Electrospun polymer nanofibers as a solid-phase extraction sorbent for the determination of trace pollutants in environmental water 显示文摘 | Qi Dongjin Kang Xuejun Chen Liqin | 2008 | Analytical and Bioanalytical Chemistry2008，390，3： | 1 |
| 11 | Ultrathin 3 V Spinel Clothed Layered Lithium-Rich Oxides as Heterostructured Cathode for High-Energy and High-Power Li-ion Batteries显示文摘In an attempt to overcome the drawbacks of high-capacity layered lithium-rich cathodes xLi2MnO3·(1–x)LiMO2(0 | Liqin Dai Ning Li Lai Chen Yuefeng Su Cheng-Meng Chen Fangyuan Su Liying Bao Shi Chen Feng Wu | 2021 | Chinese Journal of Chemistry2021，39，2： | 1 |
| 12 | Studies on the theory of single screw plasticating extrusion:Part 1L Non-plug flow solid conveying显示文摘 | Fang Shizeng Chen Liqin Zhu Fuhua | 1991 | Polymer Engineering & Science1991，31，15： | 1 |
| 13 | Studies of macrophage immuno-modulating activity of polysaccharides isolated from Paecilomyces tenuipes显示文摘 | Xiaoming Chen Jianxin Lu Yangde Zhang Jiantai He Xunzhi Guo Gengyuan Tian Liqin Jin | 2008 | International Journal of Biological Macromolecules2008，，3： | 1 |
| 14 | Active canopy sensor-based precision N management strategy for rice显示文摘 | Yinkun Yao Yuxin Miao Shanyu Huang Lei Gao Xiaobo Ma Guangming Zhao Rongfeng Jiang Xinping Chen Fusuo Zhang Kang Yu Martin Gnyp Georg Bareth Cheng Liu Liqin Zhao Wen Yang Huamin Zhu | 2012 | Agronomy for Sustainable Development2012，，4： | 1 |
| 15 | Bioconcentration and metabolism of decabromodiphenyl ether (BDE-209) result in thyroid endocrine disruption in zebrafish larvae显示文摘 | Qi Chen Liqin Yu Lihua Yang Bingsheng Zhou | 2012 | Aquatic Toxicology2012，，： | 1 |
| 16 | S-doped ot-Fe203 as a highly active heterogeneous Fenton-like catalyst towards the degrada- tion of acid orange 7 and phenol 显示文摘 | Guo Liqin Chen Feng Fan Xiangqun | 2010 | Applied Catalysis B :Environ- mental2010，96，12： | 1 |
| 17 | Truncated glycoprotein E of varicella-zoster virus is an ideal immunogen for Escherichia coli-based vaccine design显示文摘Varicella-zoster virus(VZV)is a highly infectious agent responsible for both varicella and herpes zoster disease.Despite high efficacy,there remain safety and accessibility concerns with the licensed vaccines.Here,we sought to produce a VZV g E immunogen using an E.coli expression system.We found that the soluble expression and yield of g E protein could be enhanced via C-terminal truncations to the protein,thereby facilitating a robust and scalable purification process for the purpose of vaccine manufacturing.The lead truncated g E(aa 31–358),hereafter referred to as tg E,was a homogenous monomer in solution and showed excellent antigenicity.Finally,we assessed and compared the immunogenicity of tg E with commercial v Oka LAV and Shingrix vaccine.We found that aluminum-adjuvanted tg E was immunogenic as compared with v Oka LAV.When adjuvanted with AS01B,a two-dose immunization of tg E showed comparable or better potency in antibody responses and cell-mediated immunity with those of the Shingrix vaccine at the same dosage,especially in terms of the proportion of IFN-γ-expressing CD4^(+)T cells.In conclusion,this method of E.coli-mediate tg E expression offers a cost-effective and scalable strategy to generate an ideal VZV g E immunogen for the development of both varicella and zoster vaccines. | Tingting Chen Jie Sun Sibo Zhang Tingting Li Liqin Liu Wenhui Xue Lizhi Zhou Siting Liang Zhili Yu Qingbing Zheng Hai Yu Tong Cheng Jun Zhang Ying Gu Shaowei Li Ningshao Xia | 2023 | Science China(Life Sciences)2023，66，4： | 1 |
| 18 | ROS is essential for initiation of energy deprivation-induced autophagy显示文摘Autophagy is a highly conserved degradation process in which intracellular components are engulfed into a double membrane structure,known as the autophagosomes,and then delivered to lysosomes/vacuoles for degradation(Ohsumi,2014).Recently,autophagy has been found to be responsible for maintaining glucose homeostasis in adult animals(Karsli-Uzunbas et al.,2014).However,the molecular mechanism underlying energy deprivation-induced autophagy remains relatively unclear. | Choufei Wu Yixing Li Shu Zhong Yingcong Chen Yu Xie Yuyao Feng Weijing Yao Suping Fu Yanlan Zhu Liefeng Wang Yuting Chen Liqin Zhang Jingjing Tong Cong Yi | 2021 | Journal of Genetics and Genomics2021，48，6： | 1 |
| 19 | Failure Modes and Effects Analysis on ITER DFLL-TBM system显示文摘 | Liqin Hu Run Yuan Hongli Chen Yunqing Bai | 2012 | Fusion Engineering and Design (-)2012，，78： | 1 |
| 20 | Fiber-packed SPE tips based on electrospun fibers显示文摘 | Yiyun Zhang Xuejun Kang Liqin Chen Chao Pan Yingfang Yao Zhong-Ze Gu | 2008 | Analytical and Bioanalytical Chemistry2008，，6： | 1 |
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