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| 1 | Chronology and geochemistry of the volcanic rocks in Woruo Mountain region,Northern Qiangtang depression:Implications to the Late Triassic volcanic-sedimentary events显示文摘A suite of sedimentary-volcaniclastic rocks intercalated with the volcanic rocks unconformably overlies the Triassic Xiaochaka Formation in the Woruo Mountain region, Qiangtang Basin, northern Tibet. The vitric tuff from the base of these strata gives a SHRIMP zircon U-Pb age of 216 ± 4.5 Ma, which represents the age of the Late Triassic volcanic-sedimentary events in the Woruo Mountain region, and is consistent with that of the formation of the volcanic rocks from the Nadi Kangri Formation in the Nadigangri-Shishui River zone. There is a striking similarity in geochemical signatures of the volcanic rocks from the Woruo Mountain region and its adjacent Nadigangri-Shishui River zone, indicating that all the volcanic rocks from the Qiangtang region might have the same magmatic source and similar tectonic setting during the Late Triassic. The proper recognition of the Late Triassic large-scale volcanic eruption and volcanic-sedimentary events has important implications for the interpretation of the Late Triassic biotic extinction, climatic changes and regressive events in the eastern Tethyan domain, as well as the understanding of the initiation and nature, and sedimentary features of the Qiangtang Basin during the Late Triassic-Jurassic. | WANG Jian FU XiuGen CHEN WenXi WANG ZhengJiang TAN FuWen CHEN Ming ZHUO JieWen | 2008 | Science China Earth Sciences2008，51，2： | 21 |
| 2 | Regional Distribution and Prospects of Potash in China显示文摘中国被几小大陆人块(cratons ) 的合并形成,微,在不同 paleoclimatic 背景的块和 orogenic 带。它可以与另外的大陆人块被相关,但是有它的自己的特定的特征;因此中国的水兵和大陆人的构造环境盐的盆和盐,和钾碱,形成环境有一些特定的特征:部件材料的盐,形成的进程和差异的盐形成,在盐的差别,形成的年龄,移植和集中的多重阶段,以及海洋的盐的盆的小尺寸和在丰富的液体矿物质资源的迟了的阶段和出现的盐的盆的大变化。构造地下室的性质在钾碱盆的形成上施加了关键控制效果。稳定的构造区域为在伪,稳定的区域,和伪的钾碱集中是有利的,并且伪马厩区域在一个本地稳定的构造区域为盐集中和钾碱形成是有利的。大多数中国的主要的古老的盐的盆发生在伪, cratons (大陆人块) ;特别所有海洋的盐的盆与前寒武纪的地下室发生在大陆人块。这些区域是为钾碱搜索的关键的。最相对大,可溶的盐扔的规模在相对稳定的大陆人原子核被开发。根据中国是咸的构造领域的特征,形成盆被定位,诺思中国, Yangtze 和 Tarim, Qaidam 盐 minerogenetic 领域和北 Qiangtang,西方的云南盐 minerogenetic 带可以被区分。他们的盐和钾碱前景将独立被讨论。 | ZHENG Mianping ZHANG Yongsheng YUAN Heran LIU Xifang CHEN Wenxi LI Jinsuo | 2011 | Acta Geologica Sinica(English Edition)2011，85，1： | 12 |
| 3 | A Comparative Analysis of Evaporate Sediments on Earth and Mars: Implications for the Climate Change on Mars显示文摘The knowledge of Martian salts has gone through substantial changes during the past decades. In the 70th of last century, Viking landers have noticed the existence of salts on Mars. Several salt species have been suggested from then on, such as sulfates and chlorides. However, their origin was a mystery due to the lack of observations. The recent explorations and related studies at the beginning of this century revealed that the crustal composition of Mars is similar to that of Earth, and it was hypothesized that almost one third of Martian surface was covered by oceans and lakes in the early stage of Mars. The huge water bodies may have dissolved a large quantity of ions from Martian primary rocks during the whole Noachian and Hesperian epoch. After the enormous drought event happened during the late Hesperian and the early Amazonian, these dissolved ions have formed huge salts deposits and most of them were preserved on Mars until today. To date, carbonates, sulfates, chlorides have all been detected by orbital remote sensing and by landers and rovers. However, the salt mineral assemblages on Mars seems to have some differences from those on Earth, e.g., rich in sulfates and lack of massive carbonates. To explain this difference, we propose that most of the surface carbonates precipitated from the ancient oceans may have been dissolved by the later ubiquitous acidic fluids originated from the global volcanism in the Hesperian era, and formed the enormous sulfate deposits as detected, and this hypothesis seems to be supported by the evidence that most of the sulfate deposits distribute around the Tharsis volcanic province while the survived carbonates located far from it. This process can release most of the carbon on Mars to the atmosphere in the form of CO2 and then be erased by the late heavy bombardments, which might have profound influence on the climate change happened in the Hesperian age. The positive correlation between the GRS results of the potassium distributions and the distribution of chlorides on Mars, together with the high Br concentration measured from the evaporate sediments at two Mars exploration rover landing sites, indicate that the brines in the regions where the chlorides deposited may have reached the stage for potassium salts deposition, thus we propose for the first time that potassium salts deposits might be prevalent in these regions. | ZHENG Mianping KONG Weigang ZHANG Xuefei CHEN Wenxi KONG Fanjing | 2013 | Acta Geologica Sinica(English Edition)2013，87，3： | 7 |
| 4 | GLUT1-mediated effective anti-miRNA21 pompon for cancer therapy显示文摘Oncogenic microRNAs are essential components in regulating the gene expression of cancer cells. Especially miR21, which is a major player involved of tumor initiation, progression, invasion and metastasis in several cancers. The delivery of anti-miR21 sequences has significant potential for cancer treatment. Nevertheless, since anti-miR21 sequences are extremely unstable and they need to obtain certain concentration to function, it is intensely difficult to build an effective delivery system for them.The purpose of this work is to construct a self-assembled glutathione(GSH)-responsive system with tumor accumulation capacity for effective anti-miR21 delivery and cancer therapy. A novel drug delivery nanosphere carrying millions of anti-miR21 sequences was developed through the rolling circle transcription(RCT) method. GSH-responsive cationic polymer polyethyleneimine(pOEI) was synthesized to protect the nanosphere from degradation by Dicer or other RNase in normal cells and optimize the pompon-like nanoparticle to suitable size. Dehydroascorbic acid(DHA), a targeting molecule, which is a substrate of glucose transporter 1(GLUT 1) and highly expressed on malignant tumor cells, was connected to pOEI through PEG, and then the polymer was used for contracting a RNA nanospheres into nanopompons. The anti-miR21 nanopompons showed its potential for effective cancer therapy. | Qin Guo Chao Li Wenxi Zhou Xinli Chen Yu Zhang Yifei Lu Yujie Zhang Qinjun Chen Donghui Liang Tao Sun Chen Jiang | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 5 |
| 5 | Carbon Storage Capacity of Different Plantation Types Under Sandstorm Source Control Program in Hebei Province, China显示文摘Afforestation and reforestation are effective and ecological ways of mitigating elevated atmospheric carbon dioxide(CO2) concentration and increasing carbon(C) storage in terrestrial ecosystems. In this study, we measured the above-ground(tree, herbaceous plants and litter) and below-ground(root and soil) C storage in an aspen plantation(Populus davidiana) monoculture(PD), a larch plantation(Larix pincipis-rupprechtii) monoculture(LP), a pine plantation(Pinus tabulaeformis) monoculture(PT), a larch and birch mixed plantation(L. pincipis-rupprechtii and Betula platyphlla mixed)(MLB), and an apricot plantation(Armeniaca sibirica) monoculture(AS) under the Desertification Combating Program in Hebei Province, the northern China. The objective was to assess the effect of afforestation species on ecosystem C pools of different plantation types. Results showed that C storage of LP stand(258.0 Mg/ha) and MLB(163.4 Mg/ha) were significantly higher than the C storage in PD(45.5 Mg/ha), PT(58.9 Mg/ha) and AS(49.4 Mg/ha), respectively. Soil C was the main carbon pool of the ecosystem C storage in the five plantation stands, ranging from 31.4 Mg/ha to 232.5 Mg/ha, which accounted for 69.0%–90.1% of the total ecosystem C storage. The C storage in tree layer was about 5.2%–23.2% of ecosystem C storage. The herbaceous plants and litter layers contained 1.0%–6.0% and 1.5%–3.3% of ecosystem C storage, respectively. Our results suggest that tree species should be incorporated to accurately develop regional C budget of afforestation program, and also imply that substantial differences in ecosystem C stocks among plantation types can facilitate decision making on C management. | SHEN Huitao ZHANG Wanjun YANG Xue LIU Xiuping CAO Jiansheng ZENG Xinhua ZHAO Xin CHEN Xuexun ZHANG Wenxi | 2014 | Chinese Geographical Science2014，24，4： | 3 |
| 6 | Cardiac fibroblast heat shock protein 47 aggravates cardiac fibrosis post myocardial ischemia-reperfusion injury by encouraging ubiquitin specific peptidase 10 dependent Smad4 deubiquitination显示文摘Despite complications were significantly reduced due to the popularity of percutaneous coronary intervention(PCI) in clinical trials, reperfusion injury and chronic cardiac remodeling significantly contribute to poor prognosis and rehabilitation in AMI patients. We revealed the effects of HSP47 on myocardial ischemia-reperfusion injury(IRI) and shed light on the underlying molecular mechanism.We generated adult mice with lentivirus-mediated or miRNA(mi1/133TS)-aided cardiac fibroblastselective HSP47 overexpression. Myocardial IRI was induced by 45-min occlusion of the left anterior descending(LAD) artery followed by 24 h reperfusion in mice, while ischemia-mediated cardiac remodeling was induced by four weeks of reperfusion. Also, the role of HSP47 in fibrogenesis was evaluated in cardiac fibroblasts following hypoxia-reoxygenation(HR). Extensive HSP47 was observed in murine infarcted hearts, human ischemic hearts, and cardiac fibroblasts and accelerated oxidative stress and apoptosis after myocardial IRI. Cardiac fibroblast-selective HSP47 overexpression exacerbated cardiac dysfunction caused by chronic myocardial IRI and presented deteriorative fibrosis and cell proliferation.HSP47 upregulation in cardiac fibroblasts promoted TGFβ1-Smad4 pathway activation and Smad4 deubiquitination by recruiting ubiquitin-specific peptidase 10(USP10) in fibroblasts. However, cardiac fibroblast specific USP10 deficiency abolished HSP47-mediated fibrogenesis in hearts. Moreover, blockage of HSP47 with Col003 disturbed fibrogenesis in fibroblasts following HR. Altogether, cardiac fibroblast HSP47 aggravates fibrosis post-myocardial IRI by enhancing USP10-dependent Smad4 deubiquitination,which provided a potential strategy for myocardial IRI and cardiac remodeling. | Saiyang Xie Yun Xing Wenke Shi Min Zhang Mengya Chen Wenxi Fang Shiqiang Liu Tong Zhang Xiaofeng Zeng Si Chen Shasha Wang Wei Deng Qizhu Tang | 2022 | Acta Pharmaceutica Sinica B2022，12，11： | 3 |
| 7 | Efficacy of Chaihu Jisang decoction on post-infection cough and its effect on cough reflex sensitivity显示文摘OBJECTIVE:To investigate the efficacy of Chaihu Ji Sang Decoction(CJSD),(a modification of Xiao Chaihu Tang(Minor Decoction of Bupleurum) was evaluated in patients with post-infection cough(PIC).Its effect on cough reflex sensitivity(CRS) was also described.METHODS:One hundred and eighteen patients with PIC were enrolled and randomly divided into an experimental group and control group(54 patients in each group).The experimental group was given CJSD orally,and the control group was given cetirizine hydrochloride for 7 d.Cough symptom scores and TCM symptom scores were compared before and after treatment.Efficacy,cough onset time,recurrence,and adverse drug reactions were additionally evaluated.Finally,CRS was evaluated before and after treatment of PIC patients in the experimental group.RESULTS:Fifty-two patients in the experimental group and fifty control patients completed the study.Cough symptom scores and the TCM symptom scores of the two groups were significantly improved after treatment,however cough symptoms in the experimental group 1(0,2) were significantly lower than the control group 2(1,2) after treatment(P < 0.05).Similarly,TCM symptom scores 4(0,7) in the experimental group were significantly lower than the control group 6(3,12)(P < 0.01).Overall,the effective rate of the experimental treatment(84.60%) was significantly higher than that of the control treatment(68.00%)(P < 0.01).The onset time of efficacy of the experimental treatment was one day faster than the control treatment [2(2,3) d vs 3(2,3) d,P < 0.01].The relapse rate in the experimental group(9.09%) was lower than that of the control group(29.41%)(P < 0.05).39 PIC patients in the experimental group completed a capsaicin cough challenge test before treatment.The lgC2 and lg C5 of the experimental group prior to treatment was 1.19(0.59,1.49) and 1.80(1.49,2.10),respectively.The lgC2,lg C5 of the healthy control group was 1.49(0.89,2.40) and 2.70(2.40,3.00),respectively.The differences in lgC2 and lg C5 between experimental group and healthy groups were significant at this time point(both P < 0.01).After treatment,34 patients in the experimental group received re-examination.lg C5 increased from 1.80(1.49,2.10) to 2.10(1.49,3.00).CRS after treatment/re-examination was significantly lower than those of baseline in the experimental group(P < 0.05).CONCLUSION:CJSD could effectively improve the clinical symptoms of PIC patients,with demonstrable low recurrence and safety.CJSD also significantly decreased the CRS in patients with PIC. | Hong Minli Huang Baopei Hong Chunlin Chen Huinuan Chen Wenxi Liu Chaohui Li Xinjian Li Candong | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 2 |
| 8 | High VHL Expression Reverses Warburg Phenotype and Enhances Immunogenicity in Kidney Tumor Cells显示文摘Clear cell renal cell carcinoma(ccRCC)is a frequently occurring renal cancer.The Von Hippel-Lindau disease tumor suppressor VHL,a known tumor suppressor gene,is frequently mutated in about 50%of patients with ccRCC.However,it is unclear whether VHL influences the progression of ccRCC tumors expressing wild-type VHL.In the present study,we found that higher expression of VHL was correlated with the better disease-free survival(DFS)in ccRCC patients using The Cancer Genome Atlas(TCGA)datasets.We revealed that VHL overexpression in ccRCC cells inhibited epithelial-mesenchymal transition(EMT),sterol regulatory elementbinding protein 1(SREBP1)-regulated triglyceride synthesis,and cell proliferation.Proteomic analysis provided us a global view that VHL regulated four biological processes,including metabolism,immune regulation,apoptosis,and cell movement.Importantly,we found that VHL overexpression led to up-regulated expression of proteins associated with antigen processing and interferonresponsive proteins,thus rendering ccRCC cells more sensitive to interferon treatment.We defined an interferon-responsive signature(IRS)composed of ten interferon-responsive proteins,whose m RNA expression levels were positively correlated with DFS in ccRCC patients.Taken together,our results propose that the subset of ccRCC patients with high VHL expression benefit from immunotherapy. | Songbiao Zhu Wenxi Ding Yuling Chen Weixuan Wang Renhua Xu Chongdong Liu Xiaohui Liu Haiteng Deng | 2022 | Genomics, Proteomics & Bioinformatics2022，20，4： | 1 |
| 9 | Hydrothermal Preparation and White-Light-Controlled Resistive Switching Behavior of BaWO_4 Nanospheres显示文摘In this work, BaWO4 nanospheres were successfully prepared by hydrothermal process. The bipolar resistive switching behavior of Ag/BaWO4/FTO device is observed. Moreover, this resistive switching behavior can be modulated by white light. The device can maintain superior stability in the dark and under white-light illumination. This study is useful for developing the light-controlled nonvolatile memory devices. | Bai Sun Yonghong Liu Wenxi Zhao Jinggao Wu Peng Chen | 2015 | Nano-Micro Letters2015，7，1： | 1 |
| 10 | MICROSTRUCTURE AND REVERSE SHAPE MEMORY EFFECT IN A Cu-Zn-Al ALLOY显示文摘The bainite structure in a Cu-Zn-A1 alloy related to the reverse shape memory effect hasbeen observed by means of TEM.The reverse memory effect may be improved by up to oneorder of magnitude under applied constraint stress.The widespread propagation of bainite wasconfirmed to be the diffusion controlled shear process by the parabolic configuration of sideinterface of bainite plate and the twisting of intersected bainite plates. | DONG Jianxin CHEN Fumin CHEN Jinming LIU Wenxi Tianjin University,Tianjin,China At pressent he works in Department of materials Science and Technology,University of Science and Technology,Beijing. | 1991 | Acta Metallurgica Sinica(English Letters)1991，4，3： | 1 |
| 11 | Expression of heat-resistant β-glucosidase in Escherichia coli and its application in the production of gardenia blue显示文摘Gardenia blue is a natural blue pigment that is environmentally friendly,non-toxic,and stable.The hydrolysis of geniposide,catalyzed byβ-glucosidase,is a critical step in the production process of gardenia blue.However,β-glucosidase is not resistant to high temperatures,limiting the production of gardenia blue.In this study,we investigated the effectiveness of a heat-resistant glucosidase obtained from Thermotoga maritima in the production of gardenia blue.The enzyme exhibited a maximum activity of 10.60 U/mL at 90℃.Single-factor and orthogonal analyses showed that exogenously expressed heat-resistant glucosidase reacted with 470.3μg/mL geniposide and 13.5μg/mL glycine at 94.2℃,producing a maximum yield of 26.2857μg/mL of gardenia blue after 156.6 min.When applied to the dyeing of denim,gardenia blue produced by this method yielded excellent results;the best color-fastness was achieved when an iron ion mordant was used.This study revealed the feasibility and application potential of microbial production of gardenia blue. | Wenxi Li Jielin Li Ying Xu Yan Huang Shuqi Xu Zirui Ou Xiaoli Long Xinyu Li Xinyu Liu Zening Xiao Jiaqi Huang Weizhao Chen | 2021 | Synthetic and Systems Biotechnology2021，6，3： | 1 |
| 12 | MIDRIB AND LEDGE OF BAINITE IN A Cu-Zn-Al-Mn ALLOY显示文摘The bainitic transformation in a Cu-Zn-Al-Mn alloy has been examined with TEM.The re-sults show that the stacking faults and also the bainitic midrib are found at the beginning ofbainite formation in the alloy.The stacking fault planes can pass continuously through themidrib in bainite.The growth ledges occur at the broad faces and rims of bainite.The broadand narrow faces of th ledges are parallel to the fault plane and habit plane respectively.Boththeir Miller indices are {110}B2.The moving direction of ledges is parallel to the fault plane.It may be deduced that the bainite in alloy are initially formed by shear and the process ofgrowth are go verned by propagation o f fault planes. | HAN Ming CHEN Fumin CHEN Jinming CHEN Yuru LIU Wenxi Tianjin University,Tianjin,China CHEN Fumin Professor,Dept.of Material Science and Engineering,Tianjin University Tianjin 300072,China | 1990 | Acta Metallurgica Sinica(English Letters)1990，3，5： | 1 |
| 13 | Dual sample-rate scheme for d-q harmonic acquisition of active power filter显示文摘 | YAO Wenxi LU Zhengyu CHEN Guozhu | 2002 | IEEE PESCO22002，，3： | 1 |
| 14 | Seasonal chaotic features of pulse rate in a healthy subject and a patient after coronary stenting 显示文摘 | CHEN Ying CHEN Wenxi | 2010 | Conf Proc IEEE Eng Med Biol Soc2010，，： | 1 |
| 15 | Chinese experts' consensus on diagnosis, prevention, and treatment of chemotherapyinduced hepatotoxicity显示文摘Overview Drug-induced liver injury(DILI)due to acetaminophen overdose and idiosyncratic drug reactions usually occurs 5–90 days after exposure to the causative drug.Ninety percent of DILI cases are acute.As one of the most common non-infectious liver diseases,DILI represents a growing challenge for clinicians.According to data from WHO[1],DILI is the fifth leading cause of liver disease mortality.In China,DILI accounts for 1%–5%of hospitalized patients with liver diseases,10%of patients | Wenxi Yu Yuanjue Sun Yang Yao Shiying Yu Feng Yu Jun Ma Jiejun Wang Jifeng Feng Guoping Sun Jiliang Yin Yuan Chen Li Zhang Mei Hou Xianglin Yuan Jun Liang Cheng Huang Guangru Xie Qing Xie Wen Xie | 2015 | The Chinese-German Journal of Clinical Oncology2015，14，1： | 1 |
| 16 | Rectangular bunched rntile Ti02 nanorod arrays grown on carbon fiber for dye-sensitized solar cells 显示文摘 | Guo Wenxi Xu Chen Wang Xue | 2012 | Journal of the American Chemistry Society2012，134，9： | 1 |
| 17 | Travertines in Dogai Coring Area of Tibet,China:Carbon,Oxygen and Strontium Isotopic Characteristics and Genetic Mechanism显示文摘1 Introduction Dogai Coring is a name of lake lied in the northern Tibet.There are a series of modern salt springs and theies travertines.All of salt springs have an anomaly of potassium,implying that springs water may dissolve evaporites from deep bed formation,which includes | NIU Xinsheng LIU Xifang CHEN Wenxi | 2014 | Acta Geologica Sinica(English Edition)2014，88，S1： | 0 |
| 18 | Autonomous battery-changing system for UAV's lifelong flight显示文摘Unmanned aerial vehicles(UAVs)lifelong flight is essential to accomplish various tasks,e.g.,aerial patrol,aerial rescue,etc.However,traditional UAVs have limited power to sustain their flight and need skilled operators manually control their charging process.Manufacturers and users are eagerly seeking a reliable autonomous battery-changing solution.To address this need,we propose and design an autonomous battery-changing system for UAVs using the theory of inventive problem solving(TRIZ)and user-centered design(UCD)methods.For practical application,we employ UCD to thoroughly analyze user requirements,identify multiple pairs of technical contradictions,and solve these inconsistencies using TRIZ theory.Furthermore,we design an autonomous battery-changing hardware system that meets user requirements and realizes the battery change process after the automatic landing of UAVs.Finally,we conduct experiments to validate our system’s effectiveness.The experimental results show that our battery-changing system can implement the autonomous battery-changing task,and our system has high efficiency and robustness in the real environment. | Jiyang Chen Wenxi Li Yingting Sha Yinchuan Wang Zhenqiang Zhang Shikuan Li Chaoqun Wang Sile Ma | 2023 | Biomimetic Intelligence & Robotics2023，3，2： | 0 |
| 19 | Antibody upstream sequence diversity and its biological implications revealed by repertoire sequencing显示文摘The sequence upstream of the antibody variable region(antibody upstream sequence[AUS])consists of a 5′untranslated region(5′UTR)and a preceding leader region.The sequence variations in AUS affect antibody engineering and PCR based antibody quantification and may also be implicated in mRNA transcription and translation.However,the diversity of AUSs remains elusive.Using 5′rapid amplification of cDNA ends and high-throughput antibody repertoire sequencing technique,we acquired full-length AUSs for human,rhesus macaque,cynomolgus macaque,mouse,and rat.We designed a bioinformatics pipeline and identified 3307 unique AUSs,corresponding to 3026 and 1457 unique sequences for 5′UTR and leader region,respectively.Comparative analysis indicated that 928(63.69%)leader sequences are novel relative to those recorded in the international ImMunoGeneTics information system.Evolutionarily,leader sequences are more conserved than 5′UTR and seem to coevolve with their downstream V genes.Besides,single-nucleotide polymorphisms are position dependent for leader regions and may contribute to the functional reversal of the downstream V genes.Finally,the AUGs in AUSs were found to have little impact on gene expression.Taken together,our findings can facilitate primer design for capturing antibodies efficiently and provide a valuable resource for antibody engineering and molecule-level antibody studies. | Yan Zhu Xiujia Yang Cuiyu Ma Haipei Tang Qilong Wang Junjie Guan Wenxi Xie Sen Chen Yuan Chen Minhui Wang Chunhong Lan Deqiang Sun Lai Wei Caijun Sun Xueqing Yu Zhenhai Zhang | 2021 | Journal of Genetics and Genomics2021，48，10： | 0 |
| 20 | On Some n-C2 and Strongly C2 Extensions显示文摘Let R be a ring and n be a positive integer.Then R is called a left n-C2-ring(strongly left C2-ring)if every n-generated(finitely generated)proper right ideal of R has nonzero left annihilator.We discuss some n-C2 and strongly C2 extensions,such as trivial extensions,formal triangular matrix rings,group rings and[D,C]. | Farid Kourki Jianlong Chen Wenxi Li | 2020 | Algebra Colloquium2020，27，3： | 0 |
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