|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | GLUT1-mediated effective anti-miRNA21 pompon for cancer therapy显示文摘Oncogenic microRNAs are essential components in regulating the gene expression of cancer cells. Especially miR21, which is a major player involved of tumor initiation, progression, invasion and metastasis in several cancers. The delivery of anti-miR21 sequences has significant potential for cancer treatment. Nevertheless, since anti-miR21 sequences are extremely unstable and they need to obtain certain concentration to function, it is intensely difficult to build an effective delivery system for them.The purpose of this work is to construct a self-assembled glutathione(GSH)-responsive system with tumor accumulation capacity for effective anti-miR21 delivery and cancer therapy. A novel drug delivery nanosphere carrying millions of anti-miR21 sequences was developed through the rolling circle transcription(RCT) method. GSH-responsive cationic polymer polyethyleneimine(pOEI) was synthesized to protect the nanosphere from degradation by Dicer or other RNase in normal cells and optimize the pompon-like nanoparticle to suitable size. Dehydroascorbic acid(DHA), a targeting molecule, which is a substrate of glucose transporter 1(GLUT 1) and highly expressed on malignant tumor cells, was connected to pOEI through PEG, and then the polymer was used for contracting a RNA nanospheres into nanopompons. The anti-miR21 nanopompons showed its potential for effective cancer therapy. | Qin Guo Chao Li Wenxi Zhou Xinli Chen Yu Zhang Yifei Lu Yujie Zhang Qinjun Chen Donghui Liang Tao Sun Chen Jiang | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 5 |
| 2 | Privacy Protection Algorithm for the Internet of Vehicles Based on Local Differential Privacy and Game Model显示文摘In recent years,with the continuous advancement of the intelligent process of the Internet of Vehicles(IoV),the problem of privacy leakage in IoV has become increasingly prominent.The research on the privacy protection of the IoV has become the focus of the society.This paper analyzes the advantages and disadvantages of the existing location privacy protection system structure and algorithms,proposes a privacy protection system structure based on untrusted data collection server,and designs a vehicle location acquisition algorithm based on a local differential privacy and game model.The algorithm first meshes the road network space.Then,the dynamic game model is introduced into the game user location privacy protection model and the attacker location semantic inference model,thereby minimizing the possibility of exposing the regional semantic privacy of the k-location set while maximizing the availability of the service.On this basis,a statistical method is designed,which satisfies the local differential privacy of k-location sets and obtains unbiased estimation of traffic density in different regions.Finally,this paper verifies the algorithm based on the data set of mobile vehicles in Shanghai.The experimental results show that the algorithm can guarantee the user’s location privacy and location semantic privacy while satisfying the service quality requirements,and provide better privacy protection and service for the users of the IoV. | Wenxi Han Mingzhi Cheng Min Lei Hanwen Xu Yu Yang Lei Qian | 2020 | Computers, Materials & Continua2020，，8： | 3 |
| 3 | Hull plate outspread method considering process plastic distortion显示文摘 | YU Wenxi JIANG Chunman | 1994 | Ship & Ocean Engineering1994，，8： | 1 |
| 4 | Med19 Promotes Osteosarcoma Growth and Metastasis and Associates with Prognosis显示文摘 | Wenxi Yu Zhang Zhichang Min Daliu Yang Qingcheng Du Xuefei Tang Lina Lin Feng Sun Yuanjue Zhao Hui Zheng Shuier He Aina Li Hongtao Yao Yang Zan Shen | 2014 | European Journal of Cancer2014，，： | 1 |
| 5 | Dynamic optimal control for groundw- ater optimization management with covariates 显示文摘 | Yu Furong and Lu Wenxi | 2012 | Journal of Hydroin- formatics2012，14，2： | 1 |
| 6 | Shell plate outspread considering plastic deformation fartor显示文摘 | YU Wenxi JIANG Chunman | 1994 | Shipbuilding Technology1994，，8： | 1 |
| 7 | Chinese experts' consensus on diagnosis, prevention, and treatment of chemotherapyinduced hepatotoxicity显示文摘Overview Drug-induced liver injury(DILI)due to acetaminophen overdose and idiosyncratic drug reactions usually occurs 5–90 days after exposure to the causative drug.Ninety percent of DILI cases are acute.As one of the most common non-infectious liver diseases,DILI represents a growing challenge for clinicians.According to data from WHO[1],DILI is the fifth leading cause of liver disease mortality.In China,DILI accounts for 1%–5%of hospitalized patients with liver diseases,10%of patients | Wenxi Yu Yuanjue Sun Yang Yao Shiying Yu Feng Yu Jun Ma Jiejun Wang Jifeng Feng Guoping Sun Jiliang Yin Yuan Chen Li Zhang Mei Hou Xianglin Yuan Jun Liang Cheng Huang Guangru Xie Qing Xie Wen Xie | 2015 | The Chinese-German Journal of Clinical Oncology2015，14，1： | 1 |
| 8 | Antibody upstream sequence diversity and its biological implications revealed by repertoire sequencing显示文摘The sequence upstream of the antibody variable region(antibody upstream sequence[AUS])consists of a 5′untranslated region(5′UTR)and a preceding leader region.The sequence variations in AUS affect antibody engineering and PCR based antibody quantification and may also be implicated in mRNA transcription and translation.However,the diversity of AUSs remains elusive.Using 5′rapid amplification of cDNA ends and high-throughput antibody repertoire sequencing technique,we acquired full-length AUSs for human,rhesus macaque,cynomolgus macaque,mouse,and rat.We designed a bioinformatics pipeline and identified 3307 unique AUSs,corresponding to 3026 and 1457 unique sequences for 5′UTR and leader region,respectively.Comparative analysis indicated that 928(63.69%)leader sequences are novel relative to those recorded in the international ImMunoGeneTics information system.Evolutionarily,leader sequences are more conserved than 5′UTR and seem to coevolve with their downstream V genes.Besides,single-nucleotide polymorphisms are position dependent for leader regions and may contribute to the functional reversal of the downstream V genes.Finally,the AUGs in AUSs were found to have little impact on gene expression.Taken together,our findings can facilitate primer design for capturing antibodies efficiently and provide a valuable resource for antibody engineering and molecule-level antibody studies. | Yan Zhu Xiujia Yang Cuiyu Ma Haipei Tang Qilong Wang Junjie Guan Wenxi Xie Sen Chen Yuan Chen Minhui Wang Chunhong Lan Deqiang Sun Lai Wei Caijun Sun Xueqing Yu Zhenhai Zhang | 2021 | Journal of Genetics and Genomics2021，48，10： | 0 |
| 9 | Origin of boron in the Damxung Co Salt Lake(central Tibet):Evidence from boron geochemistry and isotopes显示文摘The origin of boron in boron-rich salt lakes in the Tibetan Plateau has long been the subject of debate.The Damzung Co Salt Lake in central Tibet has high boron concentrations(B=276–313 mg/L)and is an ideal site | Lü Yuanyuan ZHENG Mianping CHEN Wenxi ZHANG Xuefei LIU Xifang WU Qian YU Jiangjiang | 2014 | Acta Geologica Sinica(English Edition)2014，88，S1： | 0 |
| 10 | Expert consensus on irrigation and intracanal medication in root canal therapy显示文摘Chemical cleaning and disinfection are crucial steps for eliminating infection in root canal treatment. However, irrigant selection or irrigation procedures are far from clear. The vapor lock effect in the apical region has yet to be solved, impeding irrigation efficacy and resulting in residual infections and compromised treatment outcomes. | Xiaoying Zou Xin Zheng Yuhong Liang Chengfei Zhang Bing Fan Jingping Liang Junqi Ling Zhuan Bian Qing Yu Benxiang Hou Zhi Chen Xi Wei Lihong Qiu Wenxia Chen Wenxi He Xin Xu Liuyan Meng Chen Zhang Liming Chen Shuli Deng Yayan Lei Xiaoli Xie Xiaoyan Wang Jinhua Yu Jin Zhao Song Shen Xuedong Zhou Lin Yue | 2024 | International Journal of Oral Science2024，16，1： | 0 |
| 11 | Extraction and identifcation of spectrum characteristics of coal and rock hydraulic fracturing and uniaxial compression signals显示文摘Microseismic(MS)events generated during coal and rock hydraulic fracturing(HF)include wet events caused by fracturing fuid injection,in addition to dry events caused by stress perturbations.The mixture of these two events makes efective fracturing MS events pickup difcult.This study is based on physical experiments of diferent coal and rock HF and uniaxial compression.The diferences of waveform characteristic parameters of various coal and rock ruptures were analyzed using the Hilbert–Huang transform,leading to some useful conclusions.The phase characteristics of the acoustic emission(AE)energy difered signifcantly and responded well to the pumping pressure curve.The AE waveforms of HF exhibit similar energy and frequency distribution characteristics after Empirical mode decomposition.The main frequency bands for coal,sandstone,and shale samples are 100–300 kHz,while the mudstone sample is in the range of 50–150 kHz.The decay ratios for coal,sandstone,shale and mudstone samples are 0.78,0.83,0.67 and 0.85,respectively.When compared to the uniaxial compression test,the main frequency bands of HF were reduced for coal,sandstone and mudstone samples,whereas shale remained essentially unchanged.The duration,instantaneous energy,and total energy of the HF waveform are smaller than those of uniaxial compression,while the decay ratio is greater,especially for the mudstone samples.The waveform characteristic parameters,trained using the multilayer perceptron neural network,can efectively identify HF and uniaxial compression events with an accuracy of 96%. | Ya′nan Qian Quangui Li Qianting Hu Zhizhong Jiang Ronghui Liu Jie Li Wenxi Li Changjun Yu | 2023 | International Journal of Coal Science & Technology2023，10，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员