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| 1 | Staged angioplasty versus regular carotid artery stenting in patients with carotid artery stenosis at high risk of hyperperfusion:a randomised clinical trial显示文摘Background and purpose Hyperperfusion(HP)is a devastating complication associated with carotid artery stenting(CAS)or endarterectomy.The efficacy and safety of staged angioplasty(SAP)in patients with CAS at high risk of HP remains unclear.We sought to determine whether SAP is superior to regular CAS in patients with high risk of HP.Methods A randomised,multicentre open-label clinical trial with blinded outcome assessment(STEP)was conducted.Patients with severe carotid stenosis at high risk of HP were randomly assigned(1:1)to the SAP or regular CAS group.The primary endpoint was hyperperfusion syndrome(HPS)and intracerebral haemorrhage(ICH)within 30 days after the procedure.Results From November 2014 to January 2017,a total of 64 patients were enrolled in 11 centres.33 patients were allocated to the SAP group and 31 to the regular CAS group.At 30 days,the rate of primary endpoint was 0.0%(0/33)in the SAP group and 9.7%(3/31)in the regular CAS group(absolute risk reduction(ARR),9.7%;95%CI−20.1% to 0.7%;p=0.11).As one of the secondary endpoints,the incidence of HP phenomenon(HPP)was lower in the SAP group than the regular CAS group(0.0%vs 22.6%,ARR,−22.6%;95% CI−36.8%to−10.2%;p=0.04).Conclusion The rate of HPS and ICH was not significantly lower in SAP group;the extended secondary endpoint of HPP,however,significantly reduced,which suggested that SAP may be a safe and effective carotid revascularisation procedure to prevent HP. | Dapeng Mo Baixue Jia Huaizhang Shi Yaxuan Sun Qingan Liu Chengzhe Fan Jianping Deng Jinglin Yuan Wei Wu Changchun Jiang Guilian Zhang Hanjun Du Ning Ma Feng Gao Xuan Sun Ligang Song Lian Liu Guangge Peng Yongjun Wang Yilong Wang Zhongrong Miao the STEP Study Group | 2021 | Stroke & Vascular Neurology2021，6，1： | 3 |
| 2 | Unsupervised noise-robust feature extraction for aerial image classification显示文摘The rich data provided by satellites and unmanned aerial vehicles bring opportunities to directly model aerial image features by extracting their spatial and structural patterns.Although convolutional autoencoders(CAEs)have been attained a remarkable performance in ideal aerial image feature extraction,they are still challenging to extract information from noisy images which are generated from capture and transmission.In this paper,a novel CAE-based noise-robust unsupervised learning method is proposed for extracting high-level features accurately from aerial images and mitigating the effect of noise.Different from conventional CAEs,the proposed method introduces the noise-robust module between the encoder and the decoder.Besides,several pooling layers in CAEs are replaced by convolutional layers with stride=2.The performance of feature extraction is evaluated by the prediction accuracy and the accuracy loss in image classification experiments.A 5-classes aerial optical scene and a 9-classes hyperspectral image(HSI)data set are utilized for optical image and HSI feature extraction,respectively.Highlevel features extracted from aerial images are utilized for image classification by a linear support vector machine(SVM)classifier.Experimental results indicate that the proposed method improves the classification accuracy for noisy images(Gaussian noise 2Dσ=0.1,3Dσ=60)in both optical images(2D 87.5%)and HSIs(3D 85.6%)compared with the traditional CAE(2D 78.6%,3D 84.2%).The accuracy loss in classification experiments increases with the increment of noise.Compared with the traditional CAE(2D 15.7%,3D 11.8%),the proposed method shows the lower classification accuracy loss in experiments(2D 0.3%,3D 6.3%).The proposed unsupervised noise-robust feature extraction method attains desirable classification accuracy in ideal input and enhances the feature extraction capability from noisy input. | LIANG Ye LU Shuai WENG Rui HAN ChengZhe LIU Ming | 2020 | Science China(Technological Sciences)2020，63，8： | 3 |
| 3 | C-reactive protein is associated with the development of tongue squamous cell carcinoma显示文摘C 反应的蛋白质(CRP ) 充当反映发炎的不同的度的 biomarker。积累的报告建议了在 CRP 和各种各样的癌症之间有一种靠近的关系。然而,在舌头的发展的 CRP 的影响有鳞的房间癌(TSCC ) 遗体不清楚。这研究的目的是在 TSCC 调查 CRP 的角色。immunohistochemical 染色和统计分析的结果证明那 CRP 表情与 TSCC 肿瘤尺寸,淋巴节点转移和病理学的区别被联系。房间数 Kit-8 (CCK-8 ) 试金表明 CRP 能在一个剂量依赖者和时间依赖者举止提高 TSCC 房间增长。而且与 CRP 刺激,增殖原子抗原(PCNA ) 表示模式介绍了的房间一条著名时间依赖者起来规定。另外, CRP 能分别地提高 TSCC 房间的侵略和迁居,由 transwell 和愈合创伤的试金揭示了。染色的 Annexin V-FITC/PI 证明 CRP 能保护 TSCC 房间免受导致饥饿、导致药的 apoptosis 的伤害。与 CRP 刺激,蛋白质表示 phosphorylated 蛋白质 kinase B (pAkt ) 铺平, phosphorylated rapamycin (pmTOR ) 的哺乳动物的目标和 phosphorylated S6 ribosomal 蛋白质(pS6 ) 显著地被增加,由西方的污点分析示威了。我们的数据建议 CRP 可以在 TSCC 的发展起一个重要作用。而且, TSCC 房间上的 CRP 的生物效果可能与 Akt, mTOR,和 S6 有关。 | Jianxin Du Wei Hu Chengzhe Yang Yegang Wang Xiaoying Wang Pishan Yang | 2018 | Acta Biochimica et Biophysica Sinica2018，50，3： | 3 |
| 4 | RNA Methylome Reveals the m^(6)A-mediated Regulation of Flavor Metabolites in Tea Leaves under Solar-withering显示文摘The epitranscriptomic mark N6-methyladenosine(m^(6)A),which is the predominant internal modification in RNA,is important for plant responses to diverse stresses.Multiple environmental stresses caused by the tea-withering process can greatly influence the accumulation of specialized metabolites and the formation of tea flavor.However,the effects of the m^(6)A-mediated regulatory mechanism on flavor-related metabolic pathways in tea leaves remain relatively uncharacterized.We performed an integrated RNA methylome and transcriptome analysis to explore the m^(6)Amediated regulatory mechanism and its effects on flavonoid and terpenoid metabolism in tea(Camellia sinensis)leaves under solar-withering conditions.Dynamic changes in global m^(6)A level in tea leaves were mainly controlled by two m^(6)A erasers(CsALKBH4A and CsALKBH4B)during solar-withering treatments.Differentially methylated peak-associated genes following solarwithering treatments with different shading rates were assigned to terpenoid biosynthesis and spliceosome pathways.Further analyses indicated that CsALKBH4-driven RNA demethylation can directly affect the accumulation of volatile terpenoids by mediating the stability and abundance of terpenoid biosynthesis-related transcripts and also indirectly influence the flavonoid,catechin,and theaflavin contents by triggering alternative splicing-mediated regulation.Our findings revealed a novel layer of epitranscriptomic gene regulation in tea flavor-related metabolic pathways and established a link between the m^(6)A-mediated regulatory mechanism and the formation of tea flavor under solar-withering conditions. | Chen Zhu Shuting Zhang Chengzhe Zhou Caiyun Tian Biying Shi Kai Xu Linjie Huang Yun Sun Yuling Lin Zhongxiong Lai Yuqiong Guo | 2023 | Genomics, Proteomics & Bioinformatics2023，21，4： | 2 |
| 5 | Independence of the brittle-ductile transition from the rubber partice size for impact-modified poly (vinyl chloride) 显示文摘 | ZHAO Chengzhe WU Guangfeng ZHAO Chao | 2006 | J Polym Sci Part B: Polym Phys2006，44，： | 1 |
| 6 | Independence of the brittle-ductile transition from the rubber particle size for impact-modified poly ( vinyl chloride) 显示文摘 | ZHAO Chengzhe WU Guangfeng ZHOU Chao | 2006 | J Polym Sci: Polym Sci2006，44，： | 1 |
| 7 | Comparison between arginine conjugated PAMAM dendrimers with structural diversity for gene delivery systems显示文摘 | Kim T I Bai ChengZhe Nam K | 2009 | J Control Release2009，2，136： | 1 |
| 8 | Fla-vonoidsfromCajanuscajanL显示文摘 | LiL(林励) XieN(谢宁) ChengZH(程紫骅) | | 中国药科大学学报0，，： | 1 |
| 9 | Progress in detectiontechnology of pyrogen in drugs 显示文摘 | XIAOGN CHENGZH CHENHA | 2009 | 中国药房2009，20，19： | 1 |
| 10 | Effects of febrile seizures in mesial temporal lobe epilepsy with hippocampal sclerosis on gene expression using bioinformatical analysis显示文摘Background:To investigate the effect of long-term febrile convulsions on gene expression in mesial temporal lobe epilepsy with hippocampal sclerosis(MTLE-HS)and explore the molecular mechanism of MTLE-HS.Methods:Microarray data of MTLE-HS were obtained from the Gene Expression Omnibus database.Differentially expressed genes(DEGs)between MTLE-HS with and without febrile seizure history were screened by the GEO2R software.Pathway enrichment and gene ontology of the DEGs were analyzed using the DAVID online database and FunRich software.Protein–protein interaction(PPI)networks among DEGs were constructed using the STRING database and analyzed by Cytoscape.Results:A total of 515 DEGs were identified in MTLE-HS samples with a febrile seizure history compared to MTLEHS samples without febrile seizure,including 25 down-regulated and 490 up-regulated genes.These DEGs were expressed mostly in plasma membrane and synaptic vesicles.The major molecular functions of those genes were voltage-gated ion channel activity,extracellular ligand-gated ion channel activity and calcium ion binding.The DEGs were mainly involved in biological pathways of cell communication signal transduction and transport.Five genes(SNAP25,SLC32A1,SYN1,GRIN1,and GRIA1)were significantly expressed in the MTLE-HS with prolonged febrile seizures.Conclusion:The pathogenesis of MTLE-HS involves multiple genes,and prolonged febrile seizures could cause differential expression of genes.Thus,investigations of those genes may provide a new perspective into the mechanism of MTLE-HS. | Yinchao Li Chengzhe Wang Peiling Wang Xi Li Liemin Zhou | 2020 | Acta Epileptologica2020，2，1： | 1 |
| 11 | Independence of the brittle-ductile transition from the rubber particle size for impact-modified poly(vinyl chloride)显示文摘 | Zhao Chengzhe Wu Guangfeng | 2006 | Journal of Polymer Science2006，44，： | 1 |
| 12 | A novel group access authentication and key agreement protocol for machine-type communication显示文摘 | Lai Chengzhe Li Hui Li Xiaoqing | 2015 | Transactions on Emerging Telecommuni- cations Technologies2015，26，3： | 1 |
| 13 | Technetium-99m-labeled annexin V imaging for detecting prosthetic joint infection in a rabbit model显示文摘Accurate and timely diagnosis of prosthetic joint infection is essential to initiate early treatment and achieve a favorable outcome.In this study,we used a rabbit model to assess the feasibility of technetium-99m-labeled annexin V for detecting prosthetic joint infection.Right knee arthroplasty was performed on 24 New Zealand rabbits.After surgery,methicillin-susceptible Staphylococcus aureus was intra-articularly injected to create a model of prosthetic joint infection(the infected group,n = 12).Rabbits in the control group were injected with sterile saline(n=12).Seven and 21 days after surgery,technetium-99m-labeled annexin V imaging was performed in 6 rabbits of each group.Images were acquired 1 and 4 hours after injection of technetium-99 mlabeled annexin V(150 MBq).The operated-to-normal-knee activity ratios were calculated for quantitative analysis.Seven days after surgery,increased technetium-99m-labeled annexin V uptake was observed in all cases.However,at 21 days a notable decrease was found in the control group,but not in the infected group.The operated-to-normal-knee activity ratios of the infected group were 1.84 ± 0.29 in the early phase and 2.19 ±0.34 in the delay phase,both of which were significantly higher than those of the control group(P=0.03 and P=0.02).The receiver operator characteristic curve analysis showed that the operated-to-normal-knee activity ratios of the delay phase at 21 days was the best indicator,with an accuracy of 80%.In conclusion,technetium-99m-labeled annexin V imaging could effectively distinguish an infected prosthetic joint from an uninfected prosthetic joint in a rabbit model. | Cheng Tang Feng Wang Yanjie Hou Shanshan Lu Wei Tian Yan Xu Chengzhe Jin Liming Wang | 2015 | The Journal of Biomedical Research2015，29，3： | 1 |
| 14 | Cyto- plasmic HSP90c expression is associated with perineural inva- sion in pancreatic cancer 显示文摘 | HUA JIANG BENSONG DUAN CHENGZH! HE | 2014 | Int J Clin Exp Pathol2014，7，6： | 1 |
| 15 | Crystallization, properties and crystal and nanoscale morphology of PET-clay nanocomposites显示文摘 | Ke Yangchuan Long Chengzhe Qi Zongneng | 1999 | J Appl Polym Sci1999，71，7： | 1 |
| 16 | Independence of the brittle-ductile transition from the rubber particle size for impact-modified poly(vinyl chloride) 显示文摘 | Zhao Chengzhe Wu Guangfeng Zhou Chao | 2006 | Polymer Chemistry2006，44，4： | 1 |
| 17 | Impacts of tourist development on vegetation in Tianlong mountains显示文摘 | ChengZH(程占红) ZhangJT(张金屯) | | 地理科学0，，： | 1 |
| 18 | Underlying Mechanism of Aconitum Lizhong Acting on Experimental Hypothermia with Indigestion in Rats: Role of Ghrelin显示文摘 | Xin Zhao Yong Wang Shijun Yang Wentong Zhang Chengzhe Zu Taotao Zhang Binghua Tang Baochun Zhang Guozhang Li Bo Deng Dayong Cai Bhushan Patwardhan | 2012 | Evidence-Based Complementary and Alternative Medicine2012，，： | 1 |
| 19 | A simple and robust handover authentication between HeNB and eNB in LTE networks显示文摘 | Jin Cao Hui Li Maode Ma Yueyu Zhang Chengzhe Lai | 2012 | Computer Networks2012，，8： | 1 |
| 20 | Allelopathiceffectsofgarlic stalks on tomato and preliminary identification of allelochemicals (大蒜秸秆对番茄的化感作用及化感物质初步鉴定)[J]显示文摘 | TONGF(佟飞) CHENGZH(程智慧) JINR(金瑞) etal | 2007 | 中国水稻化感作用论坛2007，，： | 1 |
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