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| 1 | Screening for main components associated with the idiosyncratic hepatotoxicity of a tonic herb, Polygonum multiflorum显示文摘典型药用的植物的主要成分,蓼 multiflorum (用汉语的 Heshouwu ) ,那导致特质的肝损害仍然保持不清楚。我们的以前的工作证明了有 lipopolysaccharide (LPS ) 的无毒的剂量和 Heshouwu 的治疗学的剂量的 cotreatment 能在老鼠导致肝损害,而独唱治疗不能导致看得见的损害。在现在的工作,用成分大美人和敲门在里面策略,我们发现 Heshouwu 的乙醇醋酸盐(EA ) 摘录在对待 LPS 的老鼠显示了可比较的特质的 hepatotoxicity 到整个摘录。结果显示血浆丙氨酸 aminotransferase, aspartate aminotransferase,和肝 histologic 的重要举起变化,而另外的分开的部分没能导致肝损害。有另外的分开的部分的 EA 摘录的混合在对待 LPS 的老鼠导致了可比较的特质的 hepatotoxicity 到整个摘录。化学分析进一步揭示了那 2,3,5,4-tetrahydroxy trans-stilbene-2-O -- 配糖物(trans-SG ) 和它的 cis 异构体是在 EA 的二主要混合物摘录。而且,孤立的 cis- ,并且不它的 trans 异构体,显示的可比较的特质的 hepatotoxicity 到在对待 LPS 的老鼠的 EA 摘录。cis-SG 的更高的内容从与收集的将军相比与 Heshouwu 联系的实际的肝沉醉病人在 Heshouwu 白酒或准备被检测样品。另外,血浆 metabolomics 分析证明 cis-SG-disturbing 充实显著地不同于的小径在对待 LPS 的老鼠的 trans-SG。所有这些结果建议 cis-SG 仔细与 Heshouwu 的特质的 hepatotoxicity 被联系。认为 trans-SG 的 cis-trans 异构化被紫外光或日光调停,我们的调查结果为在药发现控制 photoisomerization 并且为 Heshouwu 和芪相关的药的临床的使用用作参考。 | Chunyu Li Ming Niu Zhaofang Bai Congen Zhang Yanling Zhao Ruiyu Li Can Tu Huifang Li Jing Jing Yakun Meng Zhijie Ma Wuwen Feng Jinfa Tang Yun Zhu Jinjie Li Xiaoya Shang Zhengsheng Zou Xiaohe Xiao Jiabo Wang | 2017 | Frontiers of Medicine2017，11，2： | 41 |
| 2 | Mechanism-based anti-anxiety effects of polysaccharides extracted from Shudihuang (Radix Rehmanniae Preparata) by two-dimensional electrophoresis analysis in rat hippocampus proteins显示文摘OBJECTIVE: To investigate mechanism-based anti-anxiety effects of Shudihuang (Radix Rehmanniae Preparata) polysaccharides (RRPPs) through two-dimensional electrophoresis (2-DE) analysis with mass spectrometry (MS) of hippocampus proteins in rats treated with monosodium L-glutamate (MSG).METHODS: MSG (4 g/kg) or normal saline (NS) was injected subcutaneously into infant male rats on days 2, 4, 6, 8, 10 after birth. MSG-treated rats at 8 weeks old were given NS, diazepam, or RRPPs daily for seven consecutive days by intragastric administration, while NS-treated rats given the same volume of NS. Elevated plus maze (EPM) and light/ dark transition (LDT) tests were used to observe anti-anxiety effects of RRPPs at 1 h after the last administration. After EPM and LDT tests, hippocampus tissues were excised on ice rapidly from the brains of rats. Thereafter, 2-DE and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF/MS) were used for detecting differential proteins in hippocampus of rats so as to explore the potential mechanisms. RESULTS: RRPPs (200, 400 mg/kg) could significantly inhibit MSG-induced decrease of time and entries percentages in open zones in EPM test and numbers of light-dark transition in LDT test. Further analysis of 2-DE and MALDI-TOF/MS indicated that β-synuclein, protein DJ-1, peroxiredoxin-2, peroxiredoxin-6, dimethylarginine dimethylaminohydrolase 1 (DDAH-1) and iron-sulfur proteins were all found to be down-regulated significantly in MSG-treated rats, while such down-regulation was significantly inhibited after treatment with RRPPs. CONCLUSION: RRPPs showed anti-anxiety effects and potential mechanisms might be related to inhibiting MSG-induced down-regulation of β-synuclein, DJ-1, peroxiredoxin-2, peroxiredoxin-6, DDAH-1 and iron-sulfur proteins in hippocampus of rats. | Ying Cui Chunlei Rong Junming Wang Can Cui Li Wang Zhiyi Feng Jing Feng Bing Niu | 2013 | Journal of Traditional Chinese Medicine2013，33，4： | 19 |
| 3 | Dynamic changes of behaviors, dentate gyrus neurogenesis and hippocampal miR-124 expression in rats with depression induced by chronic unpredictable mild stress显示文摘The depression-like behavior phenotype,neurogenesis in the dentate gyrus and miR-124 expression in the hippocampus are the focus of current research on the pathogenesis of depression and antidepressant therapy.The present study aimed to clarify the dynamic changes of depression-like behavior,dentate gyrus neurogenesis and hippocampal miR-124 expression during depression induced by chronic stress to reveal pathological features at different stages of depression and to further provide insight into depression treatment.Chronic unpredictable mild stress depression models were established by exposing Sprague-Dawley rats to various mild stressors,including white noise,thermal swimming,stroboscopic illumination,soiled cages,pairing with three other stressed animals,cold swimming,tail pinch,restraint and water and food deprivation.Chronic unpredictable mild stress model rats underwent dynamic observation from 1 to 8 weeks and were compared with a control group(normal feeding without any stressors).To observe changes in the depression-like behavior phenotype during chronic unpredictable mild stress-induced depression,a sucrose preference test was used to evaluate the degree of anhedonia.An open-field test was used to evaluate locomotor activity and anxiety status.Compared with the control group,chronic unpredictable mild stress rats lost weight but did not have a depression-like behavioral phenotype at 1-4 weeks.Chronic unpredictable mild stress rats presented decreased sucrose preference and locomotor activity at 5-8 weeks.In addition,chronic unpredictable mild stress rats did not have significant anxiety-like behavior during 1-8 weeks of modeling.To observe neurogenesis dysfunctions and changes in neuronal number in the dentate gyrus during chronic unpredictable mild stress-induced depression,markers(DCX and DCX/BrdU)of neural proliferation and differentiation and the neuronal marker NeuN were assessed by immunofluorescence.Compared with the control group,neurogenesis and the neuronal number in the dentate gyrus did not change from 2 to 6 weeks;however,neural proliferation and differentiation in the dentate gyrus decreased,and the number of neurons decreased until the eighth week in the chronic unpredictable mild stress group.Real-time quantitative reverse transcription polymerase chain reaction assays and fluorescence in situ hybridization were used to measure the expression of hippocampal miR-124 during chronic unpredictable mild stress-induced depression.The results showed that the expression of hippocampal miR-124 was unchanged during the first 4 weeks but increased from 5 to 6 weeks and decreased from 7 to 8 weeks compared with the control group.These findings indicate that during chronic unpredictable mild stress-induced depression,the behavioral phenotype,miR-124 expression in the hippocampus,neurogenesis in the dentate gyrus and neuronal numbers showed dynamic changes,which suggested that various pathological changes occur at different stages of depression.All experimental procedures and protocols were approved by the Experimental Animal Ethics Committee of Guangzhou University of Chinese Medicine of China in March 2015. | Yun-Ling Huang Ning-Xi Zeng Jie Chen Jie Niu Wu-Long Luo Ping Liu Can Yan Li-Li Wu | 2020 | Neural Regeneration Research2020，15，6： | 10 |
| 4 | Low-threshold topological nanolasers based on the second-order corner state显示文摘Topological lasers are immune to imperfections and disorder.They have been recently demonstrated based on many kinds of robust edge states,which are mostly at the microscale.The realization of 2D on-chip topological nanolasers with a small footprint,a low threshold and high energy efficiency has yet to be explored.Here,we report the first experimental demonstration of a topological nanolaser with high performance in a 2D photonic crystal slab.A topological nanocavity is formed utilizing the Wannier-type 0D corner state.Lasing behaviour with a low threshold of approximately 1μW and a high spontaneous emission coupling factor of 0.25 is observed with quantum dots as the active material.Such performance is much better than that of topological edge lasers and comparable to that of conventional photonic crystal nanolasers.Our experimental demonstration of a low-threshold topological nanolaser will be of great significance to the development of topological nanophotonic circuitry for the manipulation of photons in classical and quantum regimes. | Weixuan Zhang Xin Xie Huiming Hao Jianchen Dang Shan Xiao Shushu Shi Haiqiao Ni Zhichuan Niu Can Wang Kuijuan Jin Xiangdong Zhang Xiulai Xu | 2020 | Light(Science & Applications)2020，9，1： | 10 |
| 5 | A review on applications of heuristic optimization algorithms for optimal power flow in modern power systems显示文摘Optimal power flow(OPF)is one of the key tools for optimal operation and planning of modern power systems.Due to the high complexity with continuous and discrete control variables,modern heuristic optimization algorithms(HOAs)have been widely employed for the solution of OPF.This paper provides an overview of the latest applications of advanced HOAs in OPF problems.The most frequently applied HOAs for solving the OPF problem in recent years are covered and briefly introduced,including genetic algorithm(GA),differential evolution(DE),particle swarm optimization(PSO),and evolutionary programming(EP),etc. | Ming NIU Can WAN Zhao XU | 2014 | Journal of Modern Power Systems and Clean Energy2014，2，4： | 6 |
| 6 | Erosion characteristics and mechanism of the self-resonating cavitating jet impacting aluminum specimens under the confining pressure conditions显示文摘In order to study the effects of the confining pressure on the erosion characteristics of the self-resonating cavitating jet under wellbore and deep-water conditions,experiments are conducted on aluminum specimens impinged by the organ pipe cavitation nozzle and the conical nozzle with the confining pressure in the range 0 MPa–10.0 MPa.Meanwhile,through the numerical simulation of the collapsing process of the cavitation bubble and the noise test,the cavitation erosion mechanism is analyzed.The experimental results show that the optimal standoff distance and the confining pressure can be obtained for the maximum erosion quantities,and the optimal standoff distance is 5 to 7 times greater than the equivalent nozzle outlet diameter and the confining pressure is about 2.0 MPa.Under the same conditions,the erosion caused by the cavitation nozzle is up to 2 times larger than that caused by the conical nozzle.According to the numerical simulation and the noise test,the cavitation erosion on the aluminum specimens is mostly caused by mechanical forces due to the high-frequency pressure pulse generated during the collapse of cavitation bubbles,while just a small part is caused by micro-jets. | Hua-lin Liao Sheng-li Zhao Yan-feng Cao Lei Zhang Can Yi Ji-lei Niu Li-hong Zhu | 2020 | Journal of Hydrodynamics2020，32，2： | 4 |
| 7 | Associations of tea consumption with blood pressure progression and hypertension incidence显示文摘BACKGROUND Association between tea consumption and incident hypertension remains uncertain.This study conducted to examine the health effects of tea consumption on blood pressure progression and hypertension incidence.METHODS A population-based cohort of 38,913 Chinese participants without hypertension at baseline were included in the current study.Information on tea consumption was collected through standardized questionnaires.Associations of tea consump-tion with blood pressure progression and incident hypertension were analyzed using logistic regression models and Cox propor-tional hazards regression models,respectively.RESULTS During a median follow-up of 5.9 years,17,657 individuals had experienced progression to a higher blood pressure stage and 5,935 individuals had developed hypertension.In multivariate analyses,habitual tea drinkers(≥3 times/week for at least six months)had a 17%lower risk for blood pressure progression[odds ratio(OR)=0.83,95%CI:0.79-0.88]and a 14%de-creased risk for incident hypertension[hazard ratio(HR)=0.86,95%CI:0.80-0.91]compared with non-habitual tea drinkers.In-dividuals in different baseline blood pressure groups could obtain similar benefit from habitual tea drinking.In terms of tea con-sumption amount,an inverse,linear dose-response relation between monthly consumption of tea leaves and risk of blood pres-sure progression was observed,while the risk of incident hypertension did not reduce further after consuming around 100 g of tea leaves per month.CONCLUSIONS Our study demonstrated that habitual tea consumption could provide preventive effect against blood pres-sure progression and hypertension incidence. | Xiao-Ge NIU Can CAI Fang-Chao LIU Jian-Xin LI Ke-Yong HUANG Xue-Li YANG Jie CAO Shu-Feng CHEN Hong-Fan LI Chong SHEN Ying-Xin ZHAO Dong-Sheng HU Shu-Jun GU Jian-Feng HUANG Xiang-Feng LU Dong-Feng GU | 2021 | Journal of Geriatric Cardiology2021，18，8： | 4 |
| 8 | A New PCR/LDR-Based Multiplex Functional Molecular Marker for Marker-Assisted Breeding in Rice显示文摘Marker-assisted selection or marker-aided selection(MAS)provides an effective complementary approach for conventional rice breeding with precise and speedy mobilization of target genes into elite genetic backgrounds.The targeted genes,however,may not be selected in the course of MAS due to the occasional recombination between the marker and the target gene/QTL during the many cycles of meiosis involved in breeding programs.This leads to failure in the selection of target traits(Gopalakrishnan et al,2008). | Chu Huangwei Tu Rongjian Niu Fuan Zhou Jihua Sun Bin Luo Zhongyong Cheng Can Cao Liming | 2021 | Rice science2021，28，1： | 3 |
| 9 | Measurement of air exchange rates in different indoor environments using continuous CO_2 sensors显示文摘A new air exchange rate(AER) monitoring method using continuous CO 2 sensors was developed and validated through both laboratory experiments and field studies.Controlled laboratory simulation tests were conducted in a 1-m 3 environmental chamber at different AERs(0.1-10.0 hr 1).AERs were determined using the decay method based on box model assumptions.Field tests were conducted in classrooms,dormitories,meeting rooms and apartments during 2-5 weekdays using CO 2 sensors coupled with data loggers.Indoor temperature,relative humidity(RH),and CO 2 concentrations were continuously monitored while outdoor parameters combined with on-site climate conditions were recorded.Statistical results indicated that good laboratory performance was achieved:duplicate precision was within 10%,and the measured AERs were 90%-120% of the real AERs.Average AERs were 1.22,1.37,1.10,1.91 and 0.73 hr 1 in dormitories,air-conditioned classrooms,classrooms with an air circulation cooling system,reading rooms,and meeting rooms,respectively.In an elderly particulate matter exposure study,all the homes had AER values ranging from 0.29 to 3.46 hr 1 in fall,and 0.12 to 1.39 hr 1 in winter with a median AER of 1.15. | Yan You Can Niu Jian Zhou Yating Liu Zhipeng Bai Jiefeng Zhang Fei He Nan Zhang | 2012 | Journal of Environmental Sciences2012，24，4： | 2 |
| 10 | Effects of permissive hypercap- nia on transient global cerebral ischemia - reperfusion injury in rats 显示文摘 | Zhou Q Can B Niu L | 2010 | Anesthesiology2010，112，2： | 1 |
| 11 | Tuning electronic structure ofδ-MnO_(2) by the alkali-ion(K,Na,Li)associated manganese vacancies for high-rate supercapacitors显示文摘Cation vacancies can bring numerous surprising characters due to its multifarious electron and orbit distribution.In this work,d-MnO_(2) with alkali-ion(K,Na,Li)associated manganese(Mn)vacancies is fabricated by a simple hydrothermal reaction,and the correlation between their electronic structure and pseudocapacitance are systematically investigated.FESEM/TEM images have shown that the morphology of MnO_(2) is obviously changed after the introducing of cation vacancies.The position of alkali-ion in MnO_(2) structure can be controlled by adjusting the ion concentration.XRD patterns and Raman spectra demonstrate that the alkali-ion is embedded in Mn vacancies at low concentration,while entered the interlayer of MnO_(2) at high concentration.The existence of Mn vacancies will resulting in the distortion of neighboring atoms,leading to the electronic delocalization,and thus enhancing the conductivity,pseudocapacitance and rate capability of MnO_(2).Accordingly,the specific capacitances of optimized 0.4 KMO,0.4 NaMO and 0.4 LiMO samples are enhanced about 1.9,1.6 and 1.6 times compared to pure MnO_(2).Meanwhile,the rate performance has also been improved about 76%,46%and 42%,respectively.Theoretical calculations further confirm that the Mn vacancies can generate additional occupancy states and cause an increase in carrier concentration,which will improve the conductivity and further boost the pseudocapacitance of MnO_(2).This result open up a promising approach to explore active and durable electrode materials. | Lengyuan Niu Lijin Yan Zhengwei Lu Yinyan Gong Taiqiang Chen Can Li Xinjuan Liu Shiqing Xu | 2021 | Journal of Energy Chemistry2021，30，5： | 1 |
| 12 | Long SAGE analysis of differentially expressed genes in the midgut and silk#and of yellow cocoon color sex-limited silkworm, Bombyx mot/显示文摘 | Can L P Xi J Niu Y S | 2012 | African Journal of Biotech- nology2012，11，10： | 1 |
| 13 | Distribution of Eight Blast-resistant Genes in Parents of Three-line Japonica Hybrid Rice显示文摘The distribution of rice blast-resistant genes Pi2, Pi5, Pi9, Pi54, Pia, Pib, Pit and Pita in 36 restoring lines and 42 sterile lines were detected using functional molecular markers. The results indicated that those eight blast-resistant genes distributed in the 78 tested lines at various frequencies. Six rice blast-resistant genes were detected in the sterile line Shen 11 A, containing the most rice blast-resistant genes among the 78 lines, whereas no rice blast-resistant gene was detected in the lines 8527 A, Xu1 A and 016 A. The genetic distance-based clustering analysis showed that those 78 lines could be divided into five groups. | Chu Huangwei Cheng Can Niu Fu’an Zhou Jihua Tu Rongjian Luo Zhongyong Wang Xinqi Cao Liming | 2018 | Plant Diseases and Pests2018，9，2： | 0 |
| 14 | Bio-clickable mussel-inspired peptides improve titanium-based material osseointegration synergistically with immunopolarization-regulation显示文摘Upon the osteoporotic condition,sluggish osteogenesis,excessive bone resorption,and chronic inflammation make the osseointegration of bioinert titanium(Ti)implants with surrounding bone tissues difficult,often lead to prosthesis loosening,bone collapse,and implant failure.In this study,we firstly designed clickable mussel-inspired peptides(DOPA-N3)and grafted them onto the surfaces of Ti materials through robust catechol-TiO2 coordinative interactions.Then,two dibenzylcyclooctyne(DBCO)-capped bioactive peptides RGD and BMP-2 bioactive domain(BMP-2)were clicked onto the DOPA-N3-coated Ti material surfaces via bio-orthogonal reaction.We characterized the surface morphology and biocompatibility of the Ti substrates and optimized the osteogenic capacity of Ti surfaces through adjusting the ideal ratios of BMP-2/RGD at 3:1.In vitro,the dual-functionalized Ti substrates exhibited excellent promotion on adhesion and osteogenesis of mesenchymal stem cells(MSCs),and conspicuous immunopolarization-regulation to shift macrophages to alternative(M2)phenotypes and inhibit inflammation,as well as enhancement of osseointegration and mechanical stability in osteoporotic rats.In summary,our biomimetic surface modification strategy by bio-orthogonal reaction provided a convenient and feasible method to resolve the bioinertia and clinical complications of Ti-based implants,which was conducive to the long-term success of Ti implants,especially in the osteoporotic or inflammatory conditions. | Jie Sun Yingkang Huang Huan Zhao Junjie Niu Xuwei Ling Can Zhu Lin Wang Huilin Yang Zhilu Yang Guoqing Pan Qin Shi | 2022 | Bioactive Materials2022，7，3： | 0 |
| 15 | Identification of floral fragrance components in an F_(1) population derived from Paeonia ostii 'Fengdan' × P. suffruticosa 'Chunguihuawu' Cross显示文摘Tree peony(Paeonia suffruticosa Andr.)is a unique aromatic plant famous for its huge flowers,bright colors and strong fragrance,having high ornamental,medicinal,and edible value.Research on tree peony's flower fragrance has mainly focused on the comparative analysis among its varieties,leaving the inheritance of aroma compounds in this plant an overlooked area of study.Here,the volatile components of flowers at three different flowering stages of the light fragrance-type cultivar P.ostii'Fengdan'and the strong fragrance-type cultivar P.suffruticosa'Chunguihuawu',as well as the half-opening stage flowers of 109 F_(1) progeny,were collected and characterized in-depth by dynamic headspace sampling technique combined with gas chromatography-mass spectrometry(GC-MS).Diverse profiles of volatiles that included alcohols,esters,aldehydes,terpenes,benzenes,and hydrocarbons were identified from the evaluated accessions.These results revealed that the volatile components and content of parents were significantly different,and that hybridization generated more complex volatile components.Most volatile compounds in the hybrids,especially the main aromatic components,existed in at least one of the parents,being characterized by intermediate or transgressive inheritance for the floral trait;this demonstrated that volatile compounds can be inherited from parents to progeny.Further,seven de novo aroma compounds—those present in progeny yet absent in their parents—were found in progeny.This study preliminarily clarified the segregation performance of aroma traits in tree peony hybrids,which might provide a theoretical basis for selecting breeding parents and the breeding of new varieties for aroma traits. | Tongfei Niu Chenjie Zhang Can Wang Xian Xue Yabing Zhang Lili Guo Xiaogai Hou | 2022 | Ornamental Plant Research2022，2，1： | 0 |
| 16 | Genome Characterization of COVID-19 Lineage B.1.1.7 Detected in the First Six Patients of a Cluster Outbreak——Shenzhen City,Guangdong Province,China,May 2021显示文摘Screening for coronavirus disease 2019(COVID-19)virus,also known as SARS-CoV-2,infection every seven days was performed for high-risk populations who worked at the Yantian Port in Yantian District,Shenzhen City,Guangdong Province.On May 20,2021,an oropharyngeal swab from a 44-year-old male(Case A)tested preliminarily positive for COVID-19 by a quantitative real-time reverse transcription polymerase chain reaction(RT-qPCR)method in a third-party laboratory. | Yaqing He Peihua Niu Bo Peng Ying Sun Ziquan Lyu Renli Zhang Xiang Zhao Yang Song Yenan Feng Xiujuan Tang Dongfeng Kong Xinyi Wei Can Zhu Qingju Lu Shimin Li Xiaoliang Xiao Weiwen Liu Junjia He Junjie Xia Long Chen Xuan Zou Tiejian Feng | 2021 | China CDC weekly2021，3，25： | 0 |
| 17 | On the k-error linear complexity of 2p2-periodic binary sequences显示文摘Dear editor,Pseudorandom sequences play an important role in cryptography.In particular in symmetric cryptography they serve as the secret key.So the designs of pseudorandom sequences and cryptographic indicators are the critical research directions. | Zhihua NIU Can YUAN Zhixiong CHEN Xiaoni DU Tao ZHANG | 2020 | Science China(Information Sciences)2020，63，9： | 0 |
| 18 | Ion-pair Reversed-phase×Low-pH Reversed-phase Two-dimensional Liquid Chromatography for In-depth Proteomic Profiling显示文摘High-resolution liquid chromatography separation is essential to in-depth proteomic profiling of complex biological samples.Herein,we established an ion-pair reversed-phase×reversed-phase two-dimensional liquid chromatography(IPRP×RP 2DLC)strategy for comprehensive proteomic analysis.Both RPLC separation dimensions were performed at low pH,with trifluoroacetic acid(TFA)and formic acid(FA)as mobile phase addictive,respectively.As the good separation resolution offered by ion-pairing effect of TFA,the fractionation efficiency was greatly improved with 74.0%peptides identified in just one fraction.Comparing with conventional high pH RP fractionation,the overall separation rate of IPRP was about 1.6 times that of high-pH RP,which increased the number of identified peptides by 21%.Further,2169 proteins and 8540 peptides were confidently identified from crude serum sample by our IPRP×RP 2DLC strategy,exhibiting great potential in clinical proteomics in the future. | NIU Wenxue LIU Zheyi LIU Jing LAI Can ZHANG Tingting ZHAO Heng WANG Guosheng WANG Fangjun | 2023 | Chemical Research in Chinese Universities2023，39，2： | 0 |
| 19 | Screening for main components associated with the idiosyncratic hepatotoxicity of a tonic herb,Polygonum multiflorum显示文摘Erratum to Frontiers of Medicine 201711(2):253–265 https://doi.org/10.1007/s11684-017-0508-9 The original version of this article unfortunately contained some mistakes.The panel of“LPS–/drug–”in Fig.3B(Page 259),the panels of“LPS–/EtoAc+”and“LPS–/Residue+”in Supplementary Fig.3(Page 7 in the online supplementary materials)should be corrected.The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. | Chunyu Li Ming Niu Zhaofang Bai Congen Zhang Yanling Zhao Ruiyu Li Can Tu Huifang Li Jing Jing Yakun Meng Zhijie Ma Wuwen Feng Jinfa Tang Yun Zhu Jinjie Li Xiaoya Shang Zhengsheng Zou Xiaohe Xiao Jiabo Wang | 2021 | Frontiers of Medicine2021，15，2： | 0 |
| 20 | Using Network Pharmacology and Molecular Docking Tools to Investigate the Potential Mechanism of Ephedra-Gypsum in the Treatment of Respiratory Diseases显示文摘Objective:The objective of this study was to investigate the potential mechanisms of ephedra-gypsum in the treatment ofrespiratory diseases(RDs)using network pharmacology and molecular docking techniques.Materials and Methods:The TCMSP and UniProt databases were used to mine the active components and targets of ephedra-gypsum,and the targets of RD were screened using the Online Mendelian Inheritance in Man(OMIM)and GeneCards databases.The protein-protein interaction network graph was created using the drug-disease intersection targets in the STRING database.The network diagram was analyzed using Cytoscape 3.9.1's topology function.The gene ontology(GO)and KEGG enrichment analyses were performed using the DAVID platform.Molecular docking bioactivity validation of the main active components and core targets was performed using AutoDock and PyMOL software.Results:Twenty-four compounds were screened,and 113 drug-disease targets overlapped.In total,358 biological processes,67 molecular functions,38 cellular components of GO,and 139 pathways were identified.Molecular docking analysis demonstrated the strong binding ability of tumor protein 53(TP53)-luteolin.Conclusion:The core components of ephedra-gypsum,such as quercetin,luteolin,kaempferol,and CaSO_(4)·2H_(2)O,act on key targets,such as tumor necrosis factor(TNF),interleukin-6(IL-6),TP53,and IL-1β through cytokine-mediated signaling pathways,infiammatory responses,cell proliferation,and apoptosis.This could be useful for the treatment of RD. | Can Huang Ling Yuan Yang Niu Ya-Ting Yang Yi-Fan Yang Yi Nan Hong-Li Dou Joanna Japhet | 2023 | World Journal of Traditional Chinese Medicine2023，9，2： | 0 |
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