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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Gain-of-function mutant p53 in cancer progression and therapy显示文摘p53 is a key tumor suppressor,and loss of p53 function is frequently a prerequisite for cancer development.The p53 gene is the most frequently mutated gene in human cancers;p53 mutations occur in>50%of all human cancers and in almost every type of human cancers.Most of p53 mutations in cancers are missense mutations,which produce the full-length mutant p53(mutp53)protein with only one amino acid difference from wild-type p53 protein.In addition to loss of the tumor-suppressive function of wild-type p53,many mutp53 proteins acquire new oncogenic activities independently of wild-type p53 to promote cancer progression,termed gain-of-function(GOF).Mutp53 protein often accumulates to very high levels in cancer cells,which is critical for its GOF.Given the high mutation frequency of the p53 gene and the GOF activities of mutp53 in cancer,therapies targeting mutp53 have attracted great interest.Further understanding the mechanisms underlying mutp53 protein accumulation and GOF will help develop effective therapies treating human cancers containing mutp53.In this review,we summarize the recent advances in the studies on mutp53 regulation and GOF as well as therapies targeting mutp53 in human cancers. | Cen Zhang Juan Liu Dandan Xu Tianliang Zhang Wenwei Hu Zhaohui Feng | 2020 | Journal of Molecular Cell Biology2020，12，9： | 18 |
| 3 | Tumor suppressor p53 and its gain-of-function mutants in cancer显示文摘肿瘤 suppressor p53 在肿瘤抑制起一个枢轴的作用。p53 是在癌症的最经常变异的基因。作为 transcriptionfactor, p53 主要通过它的下游的目标 genes.Thus, p53 和它的目标基因形式的 transcriptional 规定在肿瘤抑制施加它的角色表明小径调整许多生物过程 toprevent tumorigenesis 的复杂 p53。最近的研究除了 apoptosis ,房间周期拘捕和老朽揭示了那,在新陈代谢和抗氧化剂防卫进一步在肿瘤 suppression.Studies 显著地贡献到它的角色的精力的规定的 p53'sfunctions 表演许多联系肿瘤的变异的 p53 蛋白质不仅失去肿瘤 wild-typep53 的镇压功能,而且获得独立于野类型的 p53 的新 oncogenic 活动包括支持肿瘤房间增长,幸存,新陈代谢的变化,野类型的 p53 功能的 frequentloss 和在肿瘤使 p53 成为的人的变异的 p53 的 gain-of-function 极其吸引人的 targetfor 癌症治疗。不同策略和许多小分子的药为基于 p53 的肿瘤 therapy.Here 正在被开发,我们在肿瘤开发在肿瘤抑制和 gain-of-function 异种 p53 考察 p53 的机制,也 asthe 在基于 p53 的肿瘤治疗的发展的最近的进展。 | Juan Liu Cen Zhang Zhaohui Feng | 2014 | Acta Biochimica et Biophysica Sinica2014，46，3： | 15 |
| 4 | An Experimental Investigation of a new Method for Protecting Bends from Erosion in Gas-Particle Flows显示文摘Bend erosion is a fairly serious problem in conveyer pipe system. This paper intends to introduce a new antierosion method for bend: ribbed anti-erosion method. Experimental research has been done by fixing ribs in the range of 10°- 70°on the outer-wall of inside 90°-bend. As a result the experiment got anti-erosion efficiency: 93.02%. It shows that ribbed bend technology is a simple and efficient anti-erosion method. Besides, the experiments indicate that rectangle ribs tend to do more obvious anti-erosion effect than square ribs do when they have equal height. | Yao Jun Fan Jianren Zhang Benzhao Cen Kefa (Department of Energy Engineering, Zhejiang University, Hangzhou 310027, China) | 2000 | Journal of Thermal Science2000，9，2： | 15 |
| 5 | Ovary cancer incidence and mortality in China, 2011显示文摘Objective: To evaluate and analyze ovary cancer incidence and mortality in China in 2011 using ovary cancer data from population-based cancer registration in China, and to provide scientific information for its control and prevention.Methods: Invasive cases of ovary cancer were extracted and analyzed from the overall Chinese cancer database in 2011, which were based on data from 177 population-based cancer registries distributing in 28 provinces. The crude, standardized, and truncated incidences and mortalities et al. were calculated and new and deaths cases from ovary cancer throughout China and in different regions in 2011 were estimated using Chinese practical population.Results: The estimates of new ovary cancer cases and deaths were 45,223 and 18,430, respectively, in China in 2011. The crude incidence rate, age-standardized rate by Chinese standard population(ASR-C) and agestandardized rate by world standard population(ASR-W) incidence were 6.89/100,000, 5.35/100,000 and 5.08/100,000, respectively; the crude, ASR-C and ASR-W mortalities were 2.81/100,000, 2.01/100,000 and 1.99/100,000, respectively. The incidence and mortality in urban areas were higher than those in rural areas. The age-specific incidence and mortality increased rapidly from age 35-39 and peaked at age 60-64 or 75-79 years. After age 45 or 55, the age-specific incidence and death rates in urban were much higher than those in rural areas. Conclusions: Compared with GLOBOCAN 2012 data, the ovary cancer incidence in China in 2011 was at middle level, but its mortality was at low level worldwide. | Kuangrong Wei Yuanming Li Rongshou Zheng Siwei Zhang Zhiheng Liang Huishan Cen Wanqing Chen | 2015 | Chinese Journal of Cancer Research2015，27，1： | 14 |
| 6 | Genome Sequences Provide Insights into the Reticulate Origin and Unique Traits of Woody Bamboos显示文摘Polyploidization is a major driver of speciation and its importance to plant evolution has been well recognized.Bamboos comprise one diploid herbaceous and three polyploid woody lineages,and are members of the only major subfamily in grasses that diversified in forests,with the woody members having a tree-like lignified culm.In this study,we generated four draft genome assemblies of major bamboo lineages with three different ploidy levels(diploid,tetraploid,and hexaploid).We also constructed a high-density genetic linkage map for a hexaploid species of bamboo,and used a linkage-map-based strategy for genome assembly and identification of subgenomes in polyploids.Further phylogenomic analyses using a large dataset of syntenic genes with expected copies based on ploidy levels revealed that woody bamboos originated subsequent to the divergence of the herbaceous bamboo lineage,and experienced complex reticulate evolution through three independent allopolyploid events involving four extinct diploid ancestors.A shared but distinct subgenome was identified in all polyploid forms,and the progenitor of this subgenome could have been critical in ancient polyploidizations and the origin of woody bamboos.Important genetic clues to the unique flowering behavior and woody trait in bamboos were also found.Taken together,our study provides significant insights into ancient reticulate evolution at the subgenome level in the absence of extant donor species,and offers a potential model scenario for broad-scale study of angiosperm origination by allopolyploidization. | Zhen-Hua Guo Peng-Fei Ma Guo-Qian Yang Jin-Yong Hu Yun-Long Liu En-Hua Xia Mi-Cai Zhong Lei Zhao Gui-Ling Sun Yu-Xing Xu You-Jie Zhao Yi-Chi Zhang Yu-Xiao Zhang Xue-Mei Zhang Meng-Yuan Zhou Ying Guo Cen Guo Jing-Xia Liu Xia-Ying Ye Yun-Mei Chen Yang Yang Bin Han Choun-Sea Lin Ying Lu De-Zhu Li | 2019 | Molecular Plant2019，12，10： | 13 |
| 7 | Frequency comparative study of coal-fired fly ash acoustic agglomeration显示文摘Particulate pollution is main kind of atmospheric pollution.The fine particles are seriously harmful to human health and environment.Acoustic agglomeration is considered as a promising pretreatment technology for fine particle agglomeration.The mechanisms of acoustic agglomeration are very complex and the agglomeration efficiency is affected by many factors.The most important and controversial factor is frequency.Comparative studies between high-frequency and low-frequency sound source to agglomerate coal- fired fly ash were carried out to investigate the influence of frequency on agglomeration efficiency.Acoustic agglomeration theoretical analysis,experimental particle size distributions (PSDs) and orthogonal design were examined.The results showed that the 20 kHz high-frequency sound source was not suitable to agglomerate coal-fired fly ash.Only within the size ranging from 0.2 to 0.25 μm the particles agglomerated to adhere together,and the agglomerated particles were smaller than 2.5 μm.The application of low-frequency (1000-1800 Hz) sound source was proved as an advisable pretreatment with the highest agglomeration efficiency of 75.3%,and all the number concentrations within the measuring range decreased.Orthogonal design L16 (4) 3 was introduced to determine the optimum frequency and optimize acoustic agglomeration condition.According to the results of orthogonal analysis,frequency was the dominant factor of coal-fired fly ash acoustic agglomeration and the optimum frequency was 1400 Hz. | Jianzhong Liu Jie Wang Guangxue Zhang Junhu Zhou Kefa Cen | 2011 | Journal of Environmental Sciences2011，23，11： | 13 |
| 8 | Hangzhou criteria as downstaging criteria in hepatocellular ca显示文摘Background:The downstaging of hepatocellular carcinoma(HCC)has been confirmed to benefit liver transplantation(LT)patients whose tumors are beyond the transplantation criteria.Milan criteria(MC),a tumor size and number-based assessment,is currently used as the endpoint in these patients.However,many studies believe that tumor biological behavior should be added to the evaluation criteria for downstaging efficacy.Hence,this study aimed to explore the feasibility of Hangzhou criteria(HC),which introduced tumor grading and alpha-fetoprotein in addition to tumor size and number,as an endpoint of downstaging.Methods:We performed a multicenter and retrospective study of 206 patients accepted locoregional therapy(LRT)as downstaging/bridge treatment prior to LT in three centers of China.Results:Recipients were divided into four groups:failed downstaging to the HC(group A,n=46),successful downstaging to the HC(group B,n=30),remained within the HC all the time(group C,n=113),and tumor progressed(group D,n=17).The 3-year HCC recurrence probabilities of groups B and C were not significantly different(10.3%vs.11.6%,P=0.87).The HCC recurrent rate was significantly higher in group A(52.3%)compared with that in group B/C(P<0.05).Seven patients(7/76,9.2%)whose tumor exceeded the the HC were successfully downstaged to the MC,and 39.5%(30/76)to the the HC.In group B,23 patients remained beyond the MC and their survivals were as well as those of patients within the MC.Conclusions:Compared to the MC,HC downstaging criteria can give more HCC patients access to LT and furthermore,the outcome of these patients is the same as those matching MC downstaging criteria.Hangzhou downstaging criteria therefore is applicable in clinical practice. | Qi-Fan Zhan Sun-Bin Ling Yi-Nan Deng Qiao-Nan Shan Qian-Wei Ye Sheng-Jun Xu Guang-Jiang Jiang Di Lu Xu-Yong Wei Li Zhuang Wu Zhang Tian Shen Bei-Ni Cen Hai-Yang Xie Ji-Min Liu Jian Wu Shu-Sen Zheng Yang Yang Xiao Xu | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，4： | 11 |
| 9 | Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism显示文摘Amycolatopsis mediterranei 被用于 rifamycin 的工业规模生产,它在 antimycobacterial 治疗起一个重要作用。作为类 Amycolatopsis 的首先定序的染色体, 236 715 底配对的包括 10 的紧张 U32 的染色体,最大的原核生物的染色体之一到目前为止曾经被定序。不同于在 streptomycetes 发现的线性拓扑学,这个染色体是圆形的,特别地类似于 Saccharopolyspora erythraea 和奴卡氏菌属 farcinica,在发展史和分类代表他们的靠近的关系。尽管在 A 预言了 9 228 编码蛋白质的基因。mediterranei 染色体 S 与那些分享了 orthologs 的最大的数字。erythraea,它被 Streptomyces coelicolor 而非 N 出人意料地跟随。farcinica,显示不同新陈代谢的特征经由改编演变到多样的生态的壁龛。除类似于那的一个核心区域以外在 streptomycetes 普通,有典型核心特征的一个新奇“伪核心”在非核心区域以内被定义,在 21 从 26 基因为第二等的代谢物生产聚类的总数被定位的地方。位于核心的 rifamycin 生合成基因簇为 rifamycin SV 的变换编码细胞色素 P450 酶必需品到 B,由比作 rifamycin 生产 B 紧张 S699 的高度相应的簇揭示了并且进一步由基因互补证实了。A 的 genomic 信息。mediterranei 表明在看起来复杂的规章的机制的控制下面不仅为各种各样的碳来源和无机的氮混合物的广泛的利用而且为新陈代谢的中介的有效 funneling 安排进第二等的抗菌素合成进程的一个新陈代谢的网络。 | Wei Zhao Yi Zhong Hua Yuan Jin Wang Huajun Zheng Ying Wang Xufeng Cen Feng Xu Jie Bai Xiaobiao Han Gang Lu Yongqiang Zhu Zhihui Shao Han Yan Chen Li Nanqiu Peng Zilong Zhang Yunyi Zhang Wei Lin Yun Fan Zhongjun Qin Yongfei Hu Baoli Zhu Shengyue Wang Xiaoming Ding Guo-Ping Zbao | 2010 | Cell Research2010，20，10： | 10 |
| 10 | A novel 12,23-epoxy dammarane saponin from Panax notoginseng显示文摘The present study investigated the chemical constituents of the roots and rhizomes of Panax notoginseng.Compounds were isolated by various column chromatographic methods,and their structures were elucidated by the extensive analysis of spectroscopic data and chemical evidences.A novel 12,23-epoxy dammarane-type saponin,named epoxynotoginsenoside A(1),together with four known compounds(2-5),was isolated and characterized. | YUAN Cen XU Fa-Xiang HUANG Xiao-Jun LI Shao-Ping ZHANG Qing-Wen | 2015 | Chinese Journal of Natural Medicines2015，13，4： | 10 |
| 11 | Effect of Heat Treatment on Structure and Wear Resistance of High Chromium Cast Steel Containing Boron显示文摘The microstructure,mechanical properties and wear resistance of high chromium cast steel containing boron after different heat treatments were studied by means of the optical microscopy(OM),the scanning electron microscopy(SEM),X-ray diffraction(XRD),hardness,impact toughness,tensile and pin-on-disc abrasion tests.The results show that as-cast microstructures of boron-free high chromium steel consist of martensite and a few(Cr,Fe)7C3carbide,and the macro-hardness of boron-free high chromium steel is 55-57HRC.After 0.5mass% B was added into high chromium cast steel,as-cast structure transforms into eutectic(Fe,Cr)2B,(Cr,Fe)7(C,B)3and martensite,and the macro-hardness reaches 58-60HRC.High temperature quenching leads to the disconnection and isolated distribution of boride,and there are many(Cr,Fe)23(C,B)6precipitated phases in the quenching structure.Quenching from 1 050℃,high chromium steel obtained the highest hardness,and the hardness of high chromium cast steel containing boron is higher than that of boron-free high chromium steel.The change of quenching temperature has no obvious effect on impact toughness of high chromium steel,and the increase of quenching temperature leads to tensile strength having an increasing tendency.At the same quenching temperature,the wear resistance of high chromium cast steel containing boron is more excellent than that of boron-free high chromium steel.High chromium cast steel guide containing boron has good performance while using in steel bar mill. | Qi-hong CEN Hai-bin ZHANG Han-guang FU | 2014 | Journal of Iron and Steel Research(International)2014，21，5： | 8 |
| 12 | Numerical simulation of seismic damage and cracking of concrete slabs of high concrete face rockfill dams显示文摘Based on the damage constitutive model for concrete, the Weibull distribution function was used to characterize the random distribution of the mechanical properties of materials by finely subdividing concrete slab elements, and a concrete random mesoscopic damage model was established. The seismic response of a 100-m high concrete face rockfill dam(CFRD), subjected to ground motion with different intensities, was simulated with the three-dimensional finite element method(FEM), with emphasis on exploration of damage and the cracking process of concrete slabs during earthquakes as well as analysis of dynamic damage and cracking characteristics during strong earthquakes. The calculated results show that the number of damaged and cracking elements on concrete slabs grows with the duration of earthquakes. With increasing earthquake intensity, the damaged zone and cracking zone on concrete slabs grow wider. During a 7.0-magnitude earthquake, the stress level of concrete slabs is low for the CFRD, and there is almost no damage or slight damage to the slabs. While during a 9.0-magnitude strong earthquake, the percentages of damaged elements and macrocracking elements continuously ascend with the duration of the earthquake, peaking at approximately 26% and 5% at the end of the earthquake, respectively. The concrete random mesoscopic damage model can depict the entire process of sprouting, growing, connecting, and expanding of cracks on a concrete slab during earthquakes. | Wei-jun Cen Lang-sheng Wen Zi-qi Zhang Kun Xiong | 2016 | Water Science and Engineering2016，9，3： | 7 |
| 13 | Nitridation:A simple way to improve the catalytic performance of hierarchical porous ZSM-5 in benzene alkylation with methanol显示文摘Nitrided hierarchical porous ZSM-5 was synthesized by nitridation of hierarchical porous ZSM-5 with flowing ammonia at elevated temperature.The samples were characterized by XRD,SEM,Nitrogen sorption isotherms,NH3-TPD and Py-IR,and evaluated in alkylation of benzene and methanol.The result indicated that the high specific surface area of parent ZSM-5 was maintained,while the Bronsted acidity was effectively adjusted by nitridation.Moreover,the high suppression of ethylbenzene was observed on nitrided catalyst and this could be attributed to the decrease of Bronsted acidity which suppressed the methanol to olefins reactions. | Jing-Hui Lyu Hua-Lei Hu Jia-Yao Rui Qun-Feng Zhang Jie Cen Wen-Wen Han Qing-Tao Wang Xiao-Kun Chen Zhi-Yan Pan Xiao-Nian Li | 2017 | Chinese Chemical Letters2017，28，2： | 6 |
| 14 | Experimental and modeling study of de novo formation of PCDD/PCDF on MSW fly ash显示文摘polychlorinateddibenzo-p-dioxins ( PCDD )和 polychlorinated dibenzo呋喃( PCDF )的形成上的硫二氧化物( SO2 )的效果在模仿的浪费燃烧 conditions.A chlorinationmodel basedon 下面在anentrained流动反应堆( EFR )被学习了有条件的概率被采用评估 PCDD andPCDFs.Results revealedthat 的相当或相同事物模式 SO2 的存在尽管 SO2suppressed PCDD/F formation.The 预言模型 ofPCDF 显示出好 ag 。 | LI Xiao-dong ZHANG Ji YAN Jian-hua CEN Ke-fa RYAN Shawn P GULLETT Brian K LEE Chunwai | 2007 | Journal of Environmental Sciences2007，19，1： | 6 |
| 15 | Temporal and Spatial Variations of Abundance of Phycocyaninand Phycoerythrin-Rich Synechococcus in Pearl River Estuary and Adjacent Coastal Area显示文摘Three surveys were carried out in Pearl River Estuary and adjacent coastal area in May, August, and November, 2013, to investigate the temporal and spatial variations of abundance of phycoerythrin-rich Synechococcus(PE-rich SYN) and phycocyanin-rich Synechococcus(PC-rich SYN). The effects of environmental factors on the alternation of the different Synechococcus groups were also elucidated. PE-rich SYN was detected in three surveys, whereas PC-rich SYN was detected in May and August, but not in November. The highest abundances of PE-rich SYN and PC-rich SYN were recorded in August and May, with mean values of 74.17×103 and 189.92×103 cells m L-1, respectively. From May to November, the relative abundance of PE-rich SYN increased, whereas that of PC-rich SYN declined. PE-rich and PC-rich SYN presented similar horizontal distributions with high abundance in the southern estuary in May, and in the western estuary in August. The abundances of PE-rich and PC-rich SYN were high at 27–32℃and salinity of 10–20. PC-rich SYN was not detected at < 24℃, and PC:PE-rich SYN decreased in abundance with salinity increase. When less than 20 mg L-1, suspended particulate matter(SPM) was helpful for Synechococcus growth. PE-rich SYN decreased in abundance when the concentration of dissolved inorganic nitrogen increased in May and November, and the concentration of phosphate increased in November. However, PC-rich SYN abundance and nutrients showed no correlation. Principal component analysis and regression analysis indicated that PE-rich SYN significantly correlated with the principal components that were affected by environmental factors. | JIANG Tao CHAI Chao WANG Jifang ZHANG Ling CEN Jingyi LU Songhui | 2016 | Journal of Ocean University of China2016，15，5： | 6 |
| 16 | Inclusions in melting process of titanium and titanium alloys显示文摘This paper summarizes melting methods of titanium and titanium alloy, such as vacuum arc melting(VAR) and electron beam cold hearth melting(EBCHM), and the related inclusions formed when using these melting methods. Low-density inclusions are resulted from contamination of air, and high-density inclusions are caused by refractory elements. The formation process of inclusions was analysed. The removal mechanism of different kinds of inclusions was specified. Low-density inclusions are removed mainly by resolving. This is a comprehensive process containing reaction diffusion. The resolving rate of high-density inclusions is so low that these inclusions are mainly removed by sedimentation. The experiments and physical models of inclusions are detailed. In various melting methods, vacuum arc melting is prominent. However, this method cannot remove inclusions effectively, which usually results in repeat melting. Electron beam cold hearth melting has the best ability of removing inclusions. These results can provide instructions to researchers of titanium and titanium alloys. | Meng-jiang Cen Yuan Liu Xiang Chen Hua-wei Zhang Yan-xiang Li | 2019 | China Foundry2019，16，4： | 6 |
| 17 | Tumor suppressor p53 cross-talks with TRIM family proteins显示文摘p53 is a key tumor suppressor.As a transcription factor,p53 accumulates in cells in response to various stress signals and selectively transcribes its target genes to regulate a wide variety of cellular stress responses to exert its function in tumor suppression.In addition to tumor suppression,p53 is also involved in many other physiological and pathological processes,e.g.anti-infection,immune response,development,reproduction,neurodegeneration and aging.To maintain its proper function,p53 is under tight and delicate regulation through different mechanisms,particularly the posttranslational modifications.The tripartite motif(TRIM)family proteins are a large group of proteins characterized by the RING,B-Box and coiled-coil(RBCC)domains at the N-terminus.TRIM proteins play important roles in regulation of many fundamental biological processes,including cell proliferation and death,DNA repair,transcription,and immune response.Alterations of TRIM proteins have been linked to many diseases including cancer,infectious diseases,developmental disorders,and neurodegenera-tion.Interestingly,recent studies have revealed that many TRIM proteins are involved in the regulation of p53,and at the same time,many TRIM proteins are also regulated by p53.Here,we review the cross-talk between p53 and TRIM proteins,and its impact upon cellular biological processes as well as cancer and other diseases. | Juan Liu Cen Zhang Xue Wang Wenwei Hu Zhaohui Feng | 2021 | Genes & Diseases2021，8，4： | 5 |
| 18 | A new subtribal classification of Arundinarieae(Poaceae,Bambusoideae)with the description of a new genus显示文摘A new subtribal classification of the woody bamboo tribe Arundinarieae is proposed based on recent phylogenomic studies.Five subtribes,corresponding to the five major lineages of the ddRAD-seq based phylogenomic trees,are recognised:Arundinariinae(the leptomorph lineage),Ampelocalaminae(the ADH lineage),Gaoligongshaniinae(represented by Gaoligongshania),Hsuehochloinae(represented by Hsuehochloa) and Thamnocalaminae(the pachymorph lineage,i.e.,alpine bamboos).Subtribes Ampelocalaminae,Gaoligongshaniinae and Hsuehochloinae are newly established,while the circumscriptions of subtribes Arundinariinae and Thamnocalaminae differ from the traditional classification.Subtribe Arundinariinae also includes those taxa that were previous members of the subtribe Shibataeinae.Thus,among the five redefined subtribes,Arundinariinae is the most heterogenous in terms of morphology.In Arundinarieae,rhizome type has greater implications for classification than other vegetative and reproductive characters at the subtribal level.In addition,the new monotypic genus Ravenochloa is described on the basis of its mo rphological characteristics and geographical distribution to accommodate the unique phylogenetic entity of Indocalamus wilsonii. | Yu-Xiao Zhang Cen Guo De-Zhu Li | 2020 | Plant Diversity2020，42，3： | 5 |
| 19 | A cell-based high-throughput approach to identify inhibitors of influenza A virus显示文摘Influenza is one of the most common infections threatening public health worldwide and is caused by the influenza virus.Rapid emergence of drug resistance has led to an urgent need to develop new anti-influenza inhibitors.In this study we established a 293T cell line that constitutively synthesizes a virus-based negative strand RNA,which expresses Gaussia luciferase upon influenza A virus infection.Using this cell line,an assay was developed and optimized to search for inhibitors of influenza virus replication.Biochemical studies and statistical analyses presented herein demonstrate the sensitivity and reproducibility of the assay in a high-throughput format(Z 0 factor value40.8).A pilot screening provides further evidence for validation of the assay.Taken together,this work provides a simple,convenient,and reliable HTS assay to identify compounds with anti-influenza activity. | Qian Gao Zhen Wang Zhenlong Liu Xiaoyu Li Yongxin Zhang Zhizhen Zhang Shan Cen | 2014 | Acta Pharmaceutica Sinica B2014，4，4： | 5 |
| 20 | Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model显示文摘Chaperone-mediated autophagy(CMA)is a lysosome-dependent selective degradation pathway implicated in the pathogenesis of cancer and neurodegenerative diseases.However,the mechanisms that regulate CMA are not fully understood.Here,using unbiased drug screening approaches,we discover Metformin,a drug that is commonly the first medication prescribed for type 2 diabetes,can induce CMA.We delineate the mechanism of CMA induction by Metformin to be via activation of TAK1-IKKα/β signaling that leads to phosphorylation of Ser85 of the key mediator of CMA,Hsc70,and its activation.Notably,we find that amyloid-beta precursor protein(APP)is a CMA substrate and that it binds to Hsc70 in an IKKα/β-dependent manner.The inhibition of CMA-mediated degradation of APP enhances its cytotoxicity.Importantly,we find that in the APP/PS1 mouse model of Alzheimer's disease(AD),activation of CMA by Hsc70 overexpression or Metformin potently reduces the accumulated brain Aβplaque levels and reverses the molecular and behavioral AD phenotypes.Our study elucidates a novel mechanism of CMA regulation via Metformin-TAK1-IKKα/β-Hsc70 signaling and suggests Metformin as a new activator of CMA for diseases,such as AD,where such therapeutic intervention could be beneficial. | Xiaoyan Xu Yaqin Sun Xufeng Cen Bing Shan Qingwei Zhao Tingxue Xie Zhe Wang Tingjun Hou Yu Xue Mengmeng Zhang Di Peng Qiming Sun Cong Yi Ayaz Najafov Hongguang Xia | 2021 | Protein & Cell2021，12，10： | 5 |
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