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| 1 | A complete sequence and comparative analysis of a SARS-associated virus(Isolate BJ01)显示文摘The genome sequence of the Severe Acute Respiratory Syndrome (SARS)-associated virus provides essential information for the identification of pathogen(s), exploration of etiology and evolution, interpretation of transmission and pathogenesis, development of diagnostics, prevention by future vaccination, and treatment by developing new drugs. We report the complete genome sequence and comparative analysis of an isolate (BJ01) of the coronavirus that has been recognized as a pathogen for SARS. The genome is 29725 nt in size and has 11 ORFs (Open Reading Frames). It is composed of a stable region encoding an RNA-dependent RNA polymerase (composed of 2 ORFs) and a variable region representing 4 CDSs (coding sequences) for viral structural genes (the S, E, M, N proteins) and 5 PUPs (putative uncharacterized proteins). Its gene order is identical to that of other known coronaviruses. The sequence alignment with all known RNA viruses places this virus as a member in the family of Coronaviridae. Thirty putative substitutions have been identified by comparative analysis of the 5 SARS- associated virus genome sequences in GenBank. Fifteen of them lead to possible amino acid changes (non-synonymous mutations) in the proteins. Three amino acid changes, with predicted alteration of physical and chemical features, have been detected in the S protein that is postulated to beinvolved in the immunoreactions between the virus and its host. Two amino acid changes have been detected in the Mprotein, which could be related to viral envelope formation. Phylogenetic analysis suggests the possibility of non-human origin of the SARS-associated viruses but provides noevidence that they are man-made. Further efforts should focus on identifying the etiology of the SARS-associated virus and ruling out conclusively the existence of otherpossible SARS-related pathogen(s). | QIN E'de ZHU Qingyu YU Man FAN Baochang CHANG Guohui SI Bingyin YANG Bao PENG Wenming JIANG Tao LIU Bohua DENG Yongqiang LIU Hong ZHANG Yu WANG Cui LI Yuquan GAN Yonghua LI Xiaoyu L Fushuang TAN Gang CAO Wuchun, YANG Ruifu Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, Beijing 100071, China WANG Jian, LI Wei, XU Zuyuan, LI Yan, WU Qingfa, LIN Wei, CHEN Weijun, TANG Lin, DENG Yajun, HAN Yujun, LI Changfeng, LEI Meng, LI Guoqing, LI Wenjie, L Hong, SHI Jianping, TONG Zongzhong, ZHANG Feng, LI Songgang, LIU Bin, LIU Siqi, DONG Wei, WANG Jun, Gane K-S Wong, YU Jun & YANG Huanming* Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300 National Center for Genome Information, Beijing 101300, China | 2003 | Chinese Science Bulletin2003，48，10： | 121 |
| 2 | GPER agonist G1 suppresses neuronal apoptosis mediated by endoplasmic reticulum stress after cerebral ischemia/reperfusion injury显示文摘Studies have confirmed a strong association between activation of the endoplasmic reticulum stress pathway and cerebral ischemia/reperfusion(I/R) injury.In this study,three key proteins in the endoplasmic reticulum stress pathway(glucose-regulated protein 78,caspase-12,and C/EBP homologous protein) were selected to examine the potential mechanism of endoplasmic reticulum stress in the neuroprotective effect of G protein-coupled estrogen receptor.Female Sprague-Dawley rats received ovariectomy(OVX),and then cerebral I/R rat models(OVX+ I/R) were established by middle cerebral artery occlusion.Immediately after I/R,rat models were injected with 100 μg/kg E2(OVX + I/R +E2),or 100 μg/kg G protein-coupled estrogen receptor agonist G1(OVX + I/R + G1) in the lateral ventricle.Longa scoring was used to detect neurobehavioral changes in each group.Infarct volumes were measured by 2,3,5-triphenyltetrazolium chloride staining.Morphological changes in neurons were observed by Nissl staining.Terminal dexynucleotidyl transferase-mediated nick end-labeling staining revealed that compared with the OVX + I/R group,neurological function was remarkably improved,infarct volume was reduced,number of normal Nissl bodies was dramatically increased,and number of apoptotic neurons in the hippocampus was decreased after E2 and G1 intervention.To detect the expression and distribution of endoplasmic reticulum stress-related proteins in the endoplasmic reticulum,caspase-12 distribution and expression were detected by immunofluorescence,and mRNA and protein levels of glucose-regulated protein 78,caspase-12,and C/EBP homologous protein were determined by polymerase chain reaction and western blot assay.The results showed that compared with the OVX+ I/R group,E2 and G1 treatment obviously decreased mRNA and protein expression levels of glucose-regulated protein 78,C/EBP homologous protein,and caspase-12.However,the G protein-coupled estrogen receptor antagonist G15(OVX + I/R + E2 + G15) could eliminate the effect of E2 on cerebral I/R injury.These results confirm that E2 and G protein-coupled estrogen receptor can inhibit the expression of endoplasmic reticulum stress-related proteins and neuronal apoptosis in the hippocampus,thereby improving dysfunction caused by cerebral I/R injury.Every experimental protocol was approved by the Institutional Ethics Review Board at the First Affiliated Hospital of Shihezi University School of Medicine,China(approval No.SHZ A2017-171) on February 27,2017. | Zi-Wei Han Yue-Chen Chang Ying Zhou Hang Zhang Long Chen Yang Zhang Jun-Qiang Si Li Li | 2019 | Neural Regeneration Research2019，14，7： | 16 |
| 3 | Sap Flow of Populus euphratica in a Desert Riparian Forest in an Extreme Arid Region During the Growing Season显示文摘在现在的学习,热脉搏技术被使用从 4 月在一个极端干旱区域在一个荒芜的河边的森林里调查 Populus euphratica 的茎树液流动到 2003 年 10 月并且从 5 月到 2004 年 10 月。试验性的地点在在 Ejina 县的 Qidaoqiao andBayantaolai 农场,在 Heihe 河的低活动范围,中国。结果显示日报在树液流动的速度的变化显示出次要的变化。在夜里,因为根压,树液流动升起能在主要的树种类被观察。Duringthe 生长期,最大的平均速度在 7 月被观察,由 8 月列在后面,并且一样的速度在 9 月和 5 月被观察;最小的速度在 10 月被观察。到 8 月的从 6 月的 Thetranspiration 在生长期期间占了约 70% 年度全部的蒸发。P 的树液临。不同年龄的 euphratica 树能适用在顺序变化了:15 年 >
25 年 >
50 年。树液临是仔细与在微气象学的因素的变化有关与与网放射显示出一道重要线性相关的普通树液临,气温和相对湿度…… | Jian-Hua Si Qi Feng Xiao-You Zhang Zong-Qiang Chang Yong-Hong Su Hai-Yang Xi | 2007 | Journal of Integrative Plant Biology2007，49，4： | 10 |
| 4 | Weekly albumin-bound paclitaxel/cisplatin versus gemcitabine/cisplatin as first-line therapy for patients with advanced non-small-cell lung cancer:A phase II open-label clinical study显示文摘Objective: The aim of this trial was to compare both the efficacy and the safety of a weekly nanoparticle albumin-bound paclitaxel(nab-paclitaxel) plus cisplatin vs. gemcitabine plus cisplatin in patients with advanced non-small-cell lung cancer(NSCLC).Methods: A total of 84 participants received either 100 mg/m^2 nab-paclitaxel each week on d 1, 8 and 15 of a 28 day cycle, as well as cisplatin 75 mg/m^2 on d 1 every three weeks(nab-TP arm); or gemcitabine 1,000 mg/m^2 on d 1 and 8, plus cisplatin 75 mg/m^2 on d 1 every three weeks(GP arm). The primary end point was progression-free survival(PFS). The secondary end points were overall response rate(ORR) and overall survival(OS).Results: According to our analysis, the median PFS was 4.8 months for the nab-TP arm vs. 5.2 months for the GP arm(P=0.55). Analysis showed the median OS was 14.6 months for participants who were in the nab-TP arm vs. 15.1 months for those in the GP arm(P=0.94). Besides, nab-TP showed OS advantages over GP in patients harboring epidermal growth factor receptor(EGFR) mutation(26.7 vs. 15.3 months, P=0.046) and patients with a performance status of 0(23.5 vs. 14.7 months, P=0.020). It was found that incidences of drug-related grade 3 or 4 toxicities were comparable between the two treatment arms.Conclusions: Therefore, it can be seen that weekly nab-TP treatment has a similar efficacy and tolerability to GP treatment for patients who are undergoing their first-line treatment for NSCLC. It could be that survival differences among platinum doublets in the context of both EGFR mutation and performance status have the potential to be the basis for our further clinical trials. | Shanshan Qin Hui Yu Xianghua Wu Zhiguo Luo Huijie Wang Si Sun Mingzhu Huang Jia Jin Zhonghua Tao Jie Qiao Yu Feng Jialei Wang Jianhua Chang | 2019 | Chinese Journal of Cancer Research2019，31，2： | 9 |
| 5 | Butterfly distribution of Earth's radiation belt relativistic electrons induced by dayside chorus显示文摘Previous theoretical studies have shown that dayside chorus can produce butterfly distribution of energetic electrons in the Earth's radiation belts by preferentially accelerating medium pitch angle electrons, but this requires the further confirmation from highresolution satellite observation. Here, we report correlated Van Allen Probes data on wave and particle during the 11-13 April,2014 geomagnetic storm. We find that a butterfly pitch angle distribution of relativistic electrons is formed around the location L = 4.52, corresponding to the presence of enhanced dayside chorus. Using a Gaussian distribution fit to the observed chorus spectra, we calculate the bounce-averaged diffusion rates and solve two-dimensional Fokker-Planck equation. Numerical results demonstrate that acceleration by dayside chorus can yield the electron flux evolution both in the energy and butterfly pitch angle distribution comparable to the observation, providing a further evidence for the formation of butterfly distribution of relativistic electrons driven by very low frequency(VLF) plasma waves. | jin yuyue yang chang he yihua liu si zhou qinghua xiao fuliang | 2018 | Science China(Technological Sciences)2018，61，2： | 5 |
| 6 | The influence of various frequency chorus waves on electron dynamics in radiation belts显示文摘Non-adiabatic behaviour induced by the chorus-electron interaction is an important contributor to the radiation belt dynamics,and largely relies on wave frequency distribution.During the geomagnetic storm on August 2,2016,upper-band,lower-band and extremely low frequency(ELF)chorus waves were simultaneously observed within one orbit period of the Van Allen Probe B.Numerical simulations are performed to investigate the electron evolution by the observed chorus with different frequencies.The results show that various frequency chorus waves have different effects on electron dynamics.For chorus in the range f≈0.3 fce–0.7 fce,energy diffusion is the dominant process in electron evolutions.For chorus in the range 0.1 fce≤f≤0.25 fce,the pitch angle diffusion tends to be comparable to energy diffusion for Ek>0.5 MeV.For ELF chorus below 0.1 fce,the pitch angle diffusion rate is much above the energy diffusion rate,leading to potential scattering losses. | HE JiaBei JIN Yu Yue XIAO FuLiang HE ZhaoGuo YANG Chang XIE YanQiong HE Qian WANG ChengZhi SHANG XiongJun LIU Si ZHOU QingHua ZHANG Sai | 2021 | Science China(Technological Sciences)2021，64，4： | 3 |
| 7 | Generation of simultaneous H^(+)and He^(+)band EMIC waves in the nightside radiation belt显示文摘Previous studies have shown that EMIC waves occur preferentially in the afternoon sector of the magnetosphere.Here we report obliquely propagating H^(+)and He^(+)band EMIC waves detected by Van Allen Probe B in the region of MLT=22.7–23.5 during the June 20,2013 substorm.Using the correlated energetic proton data,we present continuous calculations on EMIC wave growth rates along the inward orbit in the region L=5.5–4.2.The modeled growth rate shows remarkable agreement with the observed double band EMIC waves in both temporal and spatial evolutions.The current results demonstrate that H^(+)and He^(+)band EMIC waves can be simultaneously excited in the midnight sector under appropriate conditions. | GUAN ChunYi SHANG XiongJun XIE YanQiong YANG Chang ZHANG Sai LIU Si XIAO FuLiang | 2020 | Science China(Technological Sciences)2020，63，11： | 3 |
| 8 | Elucidation of the sodium kinetics in layered P-type oxide cathodes显示文摘Sodium-ion intercalation oxides generally possess high compositional diversity according to their different stacking sequences.The sodium diffusion pathway in layered P-type materials used in sodium-ion batteries is open,which can increase their rate capability by directly transmitting Na+between adjacent triangular prismatic channels,rather than passing through an intermediate tetrahedral site in O-type structure.However,how the structure chemistry of the P-type oxides determines their electrochemical properties has not been fully understood yet.Herein,by comparing the crystalline structures,electrochemical behaviors,ion/electron transport dynamics of a couple of P-type intercalation cathodes,P2-Na_(2/3)Ni1/3Mn_(2/3)O_(2)and P3-Na_(2/3)Ni_(1/3)Mn_(2/3)O_(2)with the same compositions,we demonstrate experimentally and computationally that the P2 phase delivers better cycling stability and rate capability than the P3 counterpart due to the predominant contribution of the faster intrinsic Na diffusion kinetics in the P2 bulk.We also point out that it is the electronic conductivity that captures the key electrochemistry of layered P3-type materials and makes them possible to enhance the sodium storage performance.The results reveal that the correlation between stacking structure and functional properties in two typical layered P-type cathodes,providing new guidelines for preparing and designing alkali-metal layered oxide materials with improved battery performance. | Lianzheng Yu Haojie Dong Yu-Xin Chang Zhiwei Cheng Kang Xu Yi-Hu Feng Duo Si Xu Zhu Mengting Liu Bing Xiao Peng-Fei Wang Sailong Xu | 2022 | Science China Chemistry2022，65，10： | 3 |
| 9 | Predictive risk factors of perforation in gastric endoscopic submucosal dissection for early gastric cancer: a large, multicenter study显示文摘 | Min Kim Seong Woo Jeon Kwang Bum Cho Kyung Sik Park Eun Soo Kim Chang Keun Park Hyang Eun Seo Yun Jin Chung Joong Goo Kwon Jin Tae Jung Eun Young Kim Byeong Ik Jang Si Hyung Lee Kyeong Ok Kim Chang Hun Yang | 2013 | Surgical Endoscopy2013，，4： | 3 |
| 10 | Endoscopic submucosal dissection for early gastric cancer with undifferentiated histology: could we extend the criteria beyond?显示文摘 | Yi Young Kim Seong Woo Jeon JiYeon Kim Jung Chul Park Kwang Bum Cho Kyung Sik Park EunSoo Kim Yun Jin Chung Joong Goo Kwon Jin Tae Jung Eun Young Kim Kyeong Ok Kim ByungIk Jang Si Hyung Lee Chang Hun Yang | 2013 | Surgical Endoscopy2013，，12： | 3 |
| 11 | Upward propagation of lightning-generated whistler waves into the radiation belts显示文摘Lightning-generated whistler(LGW) waves which induce energetic electron precipitation provide an important coupling between the ionosphere and radiation belts. Using the ray-tracing technique, we examine the propagation behaviour of LGW waves and show that they can travel upward into the radiation belts during higher geomagnetic activities due to the plasmapause inward compression, particularly in cases of lower wave frequencies, lower wave normal angles and azimuthal angles. Both perpendicular and parallel group velocities of LGW waves remain in relatively small values inside the plasmasphere but change rapidly to high values outside the plasmasphere. The launching latitude increases with increasing LGW wave normal angle. These results here further reveal a detailed picture on how LGW waves escape out of the plasmasphere and onto the radiation belts. | GUO MingYue ZHOU QingHua XIAO FuLiang LIU Si HE YiHua YANG Chang | 2020 | Science China(Technological Sciences)2020，63，2： | 3 |
| 12 | Severe thrombocytopenia before liver transplantation is associated with delayed recovery of thrombocytopenia regardless of donor type显示文摘AIM: To compare the recovery of thrombocytopenia and splenomegaly during long-term follow-up after liver transplantation in patients receiving a living donor transplant or a cadaveric donor transplant. METHODS: This was a retrospective cohort study of 216 consecutive liver transplant patients who survived for > 6 mo after transplantation; 169 received a liver transplant from a living donor and 47 from a cadaveric donor. The platelet counts or spleen volumes were examined before transplant, 1, 6, and 12 mo after transplant, and then annually until 5 years after transplant. RESULTS: The mean follow-up period was 49 mo (range, 21-66). Platelet counts increased continu-ously for 5 years after orthotopic liver transplant. The restoration of platelet counts after transplant was sig-nificantly slower in patients with severe pretransplant thrombocytopenia (< 50 000/μL) until 4 years after transplant (P = 0.005). Donor type did not significantly affect the recovery of platelet count and spleen vol-ume in either patient group. In multivariate analysis, pretransplant severe thrombocytopenia (< 50 000/μL) was an independent factor associated with sustained thrombocytopenia (P < 0.001, odds ratio 6.314; con-fidence interval, 2.828-14.095). Thrombocytopenia re-appeared after transplant in seven patients with portal flow disturbance near the anastomosis site. CONCLUSION: Our study suggests that severe throm-bocytopenia before transplant is closely associated with delayed recovery of platelet count after transplant and donor type did not affect the recovery of throm-bocytopenia. The reappearance of thrombocytopenia after transplant should be considered a possible indica-tor of flow disturbance in the portal vein. | Jae Hyuck Chang Jong Young Choi Hyun Young Woo Jung Hyun Kwon Chan Ran You Si Hyun Bae Seung Kew Yoon Myung-Gyu Choi In-Sik Chung Dong Goo Kim | 2008 | World Journal of Gastroenterology2008，14，37： | 2 |
| 13 | STEREOSELECTIVE TOTAL SYNTHESIS OF(±)-4α(H)-EUDESMANE显示文摘The first stereoselective total synthesis of the biomarker(±)-4α(H)-eudesmane 1,starting from(-)-carvone in five steps,has been described. | Xin CHEN Fa Jun NAN Si Chang SHAO Li Yuan MIN Tong Shuang LI Yu Lin LI Key Laboratory of Applied Organic Chemistry and Institute of Organic Chemistry,Lanzhou University,Lanzhou 730000 | 1992 | Chinese Chemical Letters1992，3，12： | 2 |
| 14 | Panda X-III: Searching for neutrinoless double beta decay with high pressure ^(136)Xe gas time projection chambers显示文摘Searching for the neutrinoless double beta decay(NLDBD)is now regarded as the topmost promising technique to explore the nature of neutrinos after the discovery of neutrino masses in oscillation experiments.Panda X-III(particle and astrophysical xenon experiment III)will search for the NLDBD of136Xe at the China Jin Ping Underground Laboratory(CJPL).In the first phase of the experiment,a high pressure gas Time Projection Chamber(TPC)will contain 200 kg,90%136Xe enriched gas operated at10 bar.Fine pitch micro-pattern gas detector(Microbulk Micromegas)will be used at both ends of the TPC for the charge readout with a cathode in the middle.Charge signals can be used to reconstruct the electron tracks of the NLDBD events and provide good energy and spatial resolution.The detector will be immersed in a large water tank to ensure~5 m of water shielding in all directions.The second phase,a ton-scale experiment,will consist of five TPCs in the same water tank,with improved energy resolution and better control over backgrounds. | Xun Chen Chang Bo Fu Javier Galan Karl Giboni Franco Giuliani Ling Hui Gu Ke Han Xiang Dong Ji Heng Lin Jiang Lai Liu Kai Xiang Ni Hiroki Kusano Xiang Xiang Ren Shao Bo Wang Yong Yang Dan Zhang Tao Zhang Li Zhao Xiang Ming Sun Shou Yang Hu Si Yu Jian Xing Long Li Xiao Mei Li Hao Liang Huan Qiao Zhang Ming Rui Zhao Jing Zhou Ya Jun Mao Hao Qiao Si Guang Wang Ying Yuan Meng Wang Amir N.Khan Neill Raper Jian Tang Wei Wang Jia Ning Dong Chang Qing Feng Cheng Li Jian Bei Liu Shu Bin Liu Xiao Lian Wang Dan Yang Zhu Juan F.Castel Susana Cebri'an Theopisti Dafni Javier G.Garza Igor G.Irastorza Francisco J.Iguaz Gloria Luz ′on Hector Mirallas Stephan Aune Eric Berthoumieux Yann Bedfer Denis Calvet Nicole d'Hose Alain Delbart Maria Diakaki Esther Ferrer-Ribas Andrea Ferrero Fabienne Kunne Damien Neyret Thomas Papaevangelou Franck Sabatie Maxence Vanderbroucke AnDi Tan Wick Haxton Yuan Mei Chinorat Kobdaj Yu-Peng Yan | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，6： | 2 |
| 15 | Sap-flow measurement and scale transferring from sample trees to entire forest stand of Populus euphratica in desert riparian forest in extreme arid region显示文摘Understanding how the transpiration of this vegetation type responds to environmental stress is important for determining the wa-ter-balance dynamics of the riparian ecosystem threatened by groundwater depletion. Transpiration and sap flow were measured using the heat-pulse technique. The results were then projected up to the stand level to investigate the stand's water-use in relation to climate forcing in the desert riparian forest in an extreme arid region. This study took place from April through October 2003 and from May through October 2004. The experimental site was selected in the Populus euphratica Forest Reserve (101o10' E, 41o59' N) in Ejina county, in the lower Heihe River basin, China. The sapwood area was used as a scalar to extrapolate the stand-water consumption from the whole trees' water consumption measured by the heat-pulse velocity recorder (HPVR). Scale transferring from a series of individual trees to a stand was done according to the existing natural variations between trees under given environmental conditions. The application of the biometric parameters available from individual tree and stand levels was proved suitable for this purpose. A significant correlation between the sapwood area and tree diameter at breast height (DBH) was found. The prediction model is well fitted by the power model. On the basis of the prediction model, the sapwood area can be cal-culated by DBH. The sap-flow density can then be used to extrapolate the stand-water use by means of a series of mathematical models. | JianHua Si 1, Qi Feng 1, HaiYang Xi 1, ZongQiang Chang 1, YongHong Su 1, Kai Zhang 1,2 1. Cold and Arid Regions Environmental and Engineering Research Institute, Chinese Academy of Sciences, Lanzhou, Gansu 730000, China. 2. Institute of Arid Meteorology, China Meteorological Administration, Lanzhou, Gansu 730020, China. | 2009 | Research in Cold and Arid Regions2009，1，3： | 2 |
| 16 | Magnetospheric chorus wave instability induced by relativistic Kappa-type distributions显示文摘We study the field-aligned propagating magnetospheric chorus wave instability using a fully relativistic wave growth formula,the previously developed relativistic Kappa-type(KT) distribution and the regular Kappa distribution of energetic electrons.We demonstrate that the peak growth rate using the nonrelativistic Kappa simulation is higher than that using either the relativistic KT or the Kappa simulation at/above 100 keV, because the significant relativistic effect yields a reduction in the relativistic anisotropy. The relativistic anisotropy Arel basically decreases as the thermal parameter θ2 increases, allowing the peak growth by relativistic KT or Kappa distribution to stay at the lower frequency region. The growth rates tend to increase with the loss-cone parameter l because the overall anisotropy increases. Moreover, at high energy ~1.0 MeV, both the growth rate and the upper cutoff frequency become smaller as l increases for the relativistic KT calculation because the significant relativistic effect reduces both the resonant anisotropy and the number of the hot electrons, which is in contrast to the relativistic and nonrelativistic Kappa distribution calculations because the less relativistic or non-relativistic effect enhances the resonant anisotropy as l increases. The above results can be applied to the whistler-mode wave instability in the outer radiation belts of the Earth, the Jovian inner magnetosphere and other astrophysical plasmas where relativistic electrons often exist. | YANG QiWu YANG Chang HE YiHua LIU Si ZHOU QingHua XIAO FuLiang | 2016 | Science China(Technological Sciences)2016，59，11： | 2 |
| 17 | Electrocatalytic activity of non-precious metal catalyst Co-N/C toward oxygen reduction reaction显示文摘Metallic cobalt was deposited on acetylene black to synthesize a composite Co/C by chemical reduction method.A platinumfree electrocatalyst Co-N/C(800) for oxygen reduction reaction(ORR) was synthesized by mixing the composite Co/C with urea and heat-treating at 800℃.The results from linear sweep voltammograms indicated that the Co-N/C(800) is active to ORR.Theβ-Co and cobalt oxides are not the active site of the catalyst Co-N/C.However,the existence of cobalt facilitated the modification of nitrogen to carbon black and led to the formation of active site of catalyst Co-N/C(800). | Yu Jun Si Chang Guo Chen Wei Yin Hui Cai | 2010 | Chinese Chemical Letters2010，21，8： | 2 |
| 18 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 19 | High prevalence of antimicrobial resistance among clinical Streptococcus pneumoniae isolates in Asia (an ANSORP study)显示文摘 | Song JH Jung SI Ko KS Kim NY Son JS Chang HH | 2004 | Antimicrob Agents Chemother2004，48，6： | 1 |
| 20 | Image-guided hypo-fractionated stereotactic radiosurgery to spinal lesions显示文摘 | Ryu SI Chang SD Kim DH | 2001 | Neurosurgery2001，49，4： | 1 |
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