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| 1 | Rheological behaviors of coal slime produced by filter-pressing显示文摘It is an effective way to use coal slime as fuel for circulating fluidized bed boilers, which will not only solve its pollution to the environment, but also turn waste to treasure. In order to provide basic technical information for transportation of coal slime from the coal preparation plant to the boiler, this paper experimentally studied the rheological behaviors of coal slime produced by filter-pressing. By using a rotational viscometer, the influences of water content, temperature, and shear time on the rheological behaviors of coal slime were investigated. Experimental results show that the coal slime will behave like Bingham plastics with low water content and like Bingham pseudo-plastics with 37.5% water content,while like pseudo-plastics with 40% water content. This indicates that the water content of coal slime must be controlled in consideration of both transportation resistance and combustion efficiency. Study results also show that, the apparent viscosity of coal slime at 5℃ is about 1.5–1.7 times of that at 40℃ for water contents 32%–37.5%, while the influence of temperature can be neglected when the water content is 40%. With increasing of water content, the influences of shear time on the apparent viscosity of coal slime becomes less. When the water content is more than 30%, the effect of shear time is negligible. It indicates that water content has the most important influence on the rheological behaviors of coal slime. There must be an optimal water content in considering conveying resistance and combustion efficiency. The environmental temperature must also be considered in coal slime transportation. | Dai Zhaohui Shi Lele Wang Lijun Guo Chuwen | 2018 | International Journal of Mining Science and Technology2018，28，2： | 5 |
| 2 | Experimental demonstration of ultra-large-scale terahertz all-dielectric metamaterials显示文摘All-dielectric metamaterials have emerged as a promising platform for low-loss and highly efficient terahertz devices. However, existing fabrication methods have difficulty in achieving a good balance between precision and cost. Here, inspired by the nano-template-assisted self-assembly method, we develop a micro-templateassisted self-assembly(MTAS) method to prepare large-scale, high-precision, and flexible ceramic microsphere all-dielectric metamaterials with an area exceeding 900 cm × 900 cm. Free from organic solvents, vacuum, and complex equipment, the MTAS method ensures low-cost and environmentally friendly fabrication. The ceramic microsphere resonators can be readily assembled into nearly arbitrary arrangements and complex aggregates, such as dimers, trimers, quadrumers, and chains. Finally, using the heat-shrinkable substrate and dipole coupling effect, a broadband reflector with a bandwidth of 0.15 THz and a reflection of up to 95% is demonstrated.This work provides a versatile and powerful platform for terahertz all-dielectric metamaterials, with potential to be applied in a wide variety of high-efficiency terahertz devices. | KE BI DAQUAN YANG JIA CHEN QINGMIN WANG HONGYA WU CHUWEN LAN YUPING YANG | 2019 | Photonics Research2019，7，4： | 5 |
| 3 | Berberine mediates root remodeling in an immature tooth with apical periodontitis by regulating stem cells from apical papilla differentiation显示文摘Once pulp necrosis or apical periodontitis occurs on immature teeth,the weak root and open root apex are challenging to clinicians.Berberine(BBR)is a potential medicine for bone disorders,therefore,we proposed to apply BBR in root canals to enhance root repair in immature teeth.An in vivo model of immature teeth with apical periodontitis was established in rats,and root canals were filled with BBR,calcium hydroxide or sterilized saline for 3 weeks.The shape of the roots was analyzed by micro-computed tomography and histological staining.In vitro,BBR was introduced into stem cells from apical papilla(SCAPs).Osteogenic differentiation of stem cells from apical papilla was investigated by alkaline phosphatase activity,mineralization ability,and gene expression of osteogenic makers.The signaling pathway,which regulated the osteogenesis of SCAPs was evaluated by quantitative real time PCR,Western blot analysis,and immunofluorescence.In rats treated with BBR,more tissue was formed,with longer roots,thicker root walls,and smaller apex diameters.In addition,we found that BBR promoted SCAPs osteogenesis in a time-dependent and concentration-dependent manner.BBR induced the expression ofβ-catenin and enhancedβ-catenin entering into the nucleus,to up-regulate more runt-related nuclear factor 2 downstream.BBR enhanced root repair in immature teeth with apical periodontitis by activating the canonical Wnt/β-catenin pathway in SCAPs. | Yujia Cui Jing Xie Yujie Fu Chuwen Li Liwei Zheng Dingming Huang Changchun Zhou Jianxun Sun Xuedong Zhou | 2020 | International Journal of Oral Science2020，12，2： | 5 |
| 4 | Real-time monitoring of hydrogel phase transition in an ultrahigh Q microbubble resonator显示文摘The ability to sense dynamic biochemical reactions and material processes is particularly crucial for a wide range of applications,such as early-stage disease diagnosis and biomedicine development.Optical microcavities-based label-free biosensors are renowned for ultrahigh sensitivities,and the detection limit has reached a single nanoparticle/molecule level.In particular,a microbubble resonator combined with an ultrahigh quality factor(Q)and inherent microfluidic channel is an intriguing platform for optical biosensing in an aqueous environment.In this work,an ultrahigh Q microbubble resonator-based sensor is used to characterize dynamic phase transition of a thermosensitive hydrogel.Experimentally,by monitoring resonance wavelength shift and linewidth broadening,we(for the first time to our knowledge)reveal that the refractive index is increased and light scattering is enhanced simultaneously during the hydrogel hydrophobic transition process.The platform demonstrated here paves the way to microfluidical biochemical dynamic detection and can be further adapted to investigating single-molecule kinetics. | DAQUAN YANG AIQIANG WANG JIN-HUI CHEN XIAO-CHONG YU CHUWEN LAN YUEFENG JI YUN-FENG XIAO | 2020 | Photonics Research2020，8，4： | 5 |
| 5 | Identification of yellowhorn(Xanthoceras sorbifolium)WRKY transcription factor family and analysis of abiotic stress response model显示文摘WRKY transcription factors are widely distributed in higher plants and play important roles in many biological processes,including stress resistance.The recently published genome sequence of yellowhorn,an oil tree with robust resistance to cold,drought,heat,salt and alkali,provides an excellent opportunity to identify and characterize the entire yellowhorn WRKY protein family and a basis for the study of abiotic stress resistance of WRKY gene family in forest species.In the present comprehensive analysis of WRKY transcription factors in yellowhorn,65 WRKY genes were identified and defined based on their location on the chromosome.According to their structure and phylogenetic relationships,XsWRKY genes clustered into WRKY groupsⅠ-Ⅲ.Segmental duplication events played a significant role in the expansion of WRKY gene family.Furthermore,transcriptomic data and real-time quantitative PCR analysis showed that expression of XsWRKY genes responding to salt and drought stresses and a hormone treatment.We also determined structures of the encoded proteins,c is-elements of the promoter region,and expression patterns.These results provide a foundation for the study of the biological function of WRKY transcription factors in yellowhorn. | Zhi Liu Saiyinduleng Qiaoying Chang Chuwen Cheng Zhimin Zheng Song Yu | 2021 | Journal of Forestry Research2021，32，3： | 3 |
| 6 | A Small-Divergence-Angle Orbital Angular Momentum Metasurface Antenna显示文摘Electromagnetic waves carrying an orbital angular momentum (OAM) are of great interest. However, most OAM antennas presentdisadvantages such as a complicated structure, low efficiency, and large divergence angle, which prevents their practicalapplications. So far, there are few papers and research focuses on the problem of the divergence angle. Herein, a metasurfaceantenna is proposed to obtain the OAM beams with a small divergence angle. The circular arrangement and phase gradient wereused to simplify the structure of the metasurface and obtain the small divergence angle, respectively. The proposed metasurfaceantenna presents a high transmission coefficient and effectively decreases the divergence angle of the OAM beam. All thetheoretical analyses and derivation calculations were validated by both simulations and experiments. This compact structurepaves the way to generate OAM beams with a small divergence angle. | Jianchun Xu Ke Bi Ru Zhang Yanan Hao Chuwen Lan Klaus D.McDonald-Maier Xiaojun Zhai Zidong Zhang Shanguo Huang | 2019 | Research2019，，1： | 3 |
| 7 | Absolute band gaps of a two-dimensional triangular-lattice dielectric photonic crystal with different shapes显示文摘Absolute band gaps of a two-dimensional triangular-lattice photonic crystal are calculated with the finite-difference time-domain method in this paper.Through calculating the photonic band structures of the triangular-lattice photonic crystal consisting of Ge rods immersed in air with different shapes,it is found that a large absolute band gap of 0.098 (2c/a) can be obtained for the structures with hollow triangular Ge rods immersed in air,corresponding to 19.8% of the middle frequency.The influence of the different factors on the width of the absolute band gaps is also discussed. | FENG Shuai*,YANG YuPing,LAN ChuWen,BAI ZhenZhen & WANG YiQuan School of Science,Minzu University of China,Beijing 100081,China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，10： | 3 |
| 8 | NUPR1 promotes the proliferation and metastasis of oral squamous cell carcinoma cells by activating TFE3-dependent autophagy显示文摘Oral squamous cell carcinoma(OSCC)is the most common type of oral malignancy,and metastasis accounts for the poor prognosis of OSCC.Autophagy is considered to facilitate OSCC development by mitigating various cellular stresses;nevertheless,the mechanisms of autophagy in OSCC cell proliferation and metastasis remain unknown.In our study,high-sensitivity label-free quantitative proteomics analysis revealed nuclear protein 1(NUPR1)as the most significantly upregulated protein in formalin-fixed paraffin-embedded tumour samples derived from OSCC patients with or without lymphatic metastasis. | Tengfei Fan Xiaoning Wang Sheng Zhang Ping Deng Yi Jiang Yidan Liang Sheng Jie Qing Wang Chuwen Li Guocai Tian Zhen Zhang Zhenhu Ren Bo Li Yanrong Chen Zhijing He Yan Luo Mingliang Chen Hanjiang Wu Zhengping Yu Huifeng Pi Zhou Zhou Zhiyuan Zhang | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 2 |
| 9 | A novel transcription factor CmMYB012 inhibits flavone and anthocyanin biosynthesis in response to high temperatures in chrysanthemum显示文摘Flavones are among the major colorless pigments synthesized through branches of the flavonoid pathway in plants.However,due to the absence of a gene encoding flavone synthase(FNS)in the model plant Arabidopsis thaliana species,the regulatory mechanism of FNS-catalyzed flavone biosynthesis has rarely been studied in plants.Here,it was found that flavones play a predominant role in the elimination of excess reactive oxygen species(ROS)at high temperatures in colorless plant organs.A novel atypical subgroup 7(SG7)R2R3-MYB transcription factor,CmMYB012,was found to be induced in response to prolonged high temperatures and to inhibit flavone biosynthesis by directly regulating CmFNS.Moreover,CmMYB012 was also found to inhibit anthocyanin biosynthesis by suppressing the expression of CmCHS,CmDFR,CmANS,and CmUFGT.CmMYB012 overexpression exerted a negative in fluence on plant fitness and pink flower color formation,while CmMYB012 suppression had the opposite effect in response to high temperatures.Our findings provide new insights into the mechanisms by which high temperatures regulate the metabolism of flavones and anthocyanins to affect plant fitness and flower color formation. | Li-Jie Zhou Zhiqiang Geng Yuxi Wang Yiguang Wang Shenhui Liu Chuwen Chen Aiping Song Jiafu Jiang Sumei Chen Fadi Chen | 2021 | Horticulture Research2021，8，1： | 2 |
| 10 | Isolation and Identification of Serotype O101 Bovine Pathogenic Escherichia coli with Multidrug Resistance显示文摘[Objective]The paper was to isolate and identify a multidrug-resistance bovine pathogenic Escherichia coli. [Method]The dead cases of calf diarrhea were collected from a large-scale beef cattle farm,and the isolated pathogen was conducted molecular identification,serological identification,drug sensitivity test,and mice pathogenicity test,respectively. Targeted therapy was undertaken thereafter to herds. [Result] One strain of bovine pathogenic E. coli,serotype O101 with strong multidrug resistance and high pathogenicity to mice,was successfully isolated. It was used to develop sensitive drug for timely treating follow-up diarrhea calves,and successfully controlled calf diarrhea in the farm. [Conclusion]The results provide a basis for effective prevention and control of bovine colibacillosis. | Li Shuguang Liu Xiaoyun Wang Yumao Li Feng Lin Chuwen Shen Zhiqiang Li Jinlin | 2017 | Animal Husbandry and Feed Science2017，9，5： | 1 |
| 11 | A Hybrid Aspect Based Latent Factor Model for Recommendation显示文摘Recommender system has been recognized as a superior way for solving personal information overload problem.More and more aspect-based models are leveraging user ratings and extracting information from review texts to support recommendation.Aspect-based latent factor model predicts user ratings relying on latent aspect inferred from user reviews.It usually constructs only a single global model for all users,which may be not sufficient to capture the diversity of users'preferences and leave some items or users be badly modeled.We propose a Hybrid aspect-based latent factor model(HALFM),which jointly optimizes the Global aspect-based latent factor model(GALFM)and the Local Aspect-based Latent Factor Models(LALFM),their user-specific combination,and the assignment of users to the LALFMs.HALFM makes prediction by combining user-specific of GALFM and many LALFMs.Experimental results demonstrate that the proposed HALFM outperforms most of aspectbased recommendation techniques in rating prediction. | YUAN Hanning CHEN Zhengyu YANG Jingting WANG Shuliang GENG Jing KE Chuwen | 2020 | Chinese Journal of Electronics2020，29，3： | 1 |
| 12 | Spontaneous rupture of hepatocellular carcinoma trans-arterial embolization or hepatectomy?显示文摘Spontaneous rupture and hemorrhage of hepatocellular carcinoma(HCC)is one of the serious complications leading to death in patients with primary liver cancer.Approximately 9-10%of those patients with liver cancer die of from spontaneous rupture and hemorrhage,which is often accompanied by abdominal metastasis and seriously affects their prognosis(1). | Qingbo Feng Xiaoyin Liu Xuping Feng Chuwen Chen Jiaxin Li Yong Zeng | 2022 | Hepatobiliary Surgery and Nutrition2022，11，6： | 1 |
| 13 | A conserved MST1/2–YAP axis mediates Hippo signaling during lung growth显示文摘 | Chuwen Lin Erica Yao Pao-Tien Chuang | 2015 | Developmental Biology2015，，： | 1 |
| 14 | Candidate therapeutic agents in a newly established triple wild-typemucosalmelanoma cell line显示文摘Background:Mucosalmelanoma has characteristically distinct genetic features and typically poor prognosis.The lack of representativemucosal melanoma models,especially cell lines,has hindered translational research on this melanoma subtype.In this study,we aimed to establish and provide the biological properties,genomic features and the pharmacological profiles of a mucosal melanoma cell line that would contribute to the understanding and treatment optimization of molecularly-defined mucosal melanoma subtype.Methods:The sample was collected from a 67-year-old mucosal melanoma patient and processed into pieces for the establishment of cell line and patientderived xenograft(PDX)model.The proliferation and tumorigenic property of cancer cells from different passageswere evaluated,andwhole-genome sequencing(WGS)was performed on the original tumor,PDX,established cell line,and the matched blood to confirm the establishment and define the genomic features of this cell line.AmpliconArchitect was conducted to depict the architecture of amplified regions detected by WGS.High-throughput drug screening(HTDS)assay including a total of 103 therapeutic agents was implemented on the established cell line,and selected candidate agents were validated in the corresponding PDX model.Results:A mucosal melanoma cell line,MM9H-1,was established which exhibited robust proliferation and tumorigenicity after more than 100 serial passages.Genomic analysis of MM9H-1,corresponding PDX,and the original tumor showed genetic fidelity across genomes,and MM9H-1 was defined as a triple wild-type(TWT)melanoma subtype lacking well-characterized“driver mutations”.Instead,the amplification of several oncogenes,telomerase reverse transcriptase(TERT),v-Rafmurine sarcoma viral oncogene homolog B1(BRAF),melanocyte Inducing transcription factor(MITF)and INO80 complex ATPase subunit(INO80),via large-scale genomic rearrangement potentially contributed to oncogenesis of MM9H-1.Moreover,HTDS identified proteasome inhibitors,especially bortezomib,as promising therapeutic candidates for MM9H-1,which was verified in the corresponding PDX model in vivo.Conclusions:We established and characterized a new mucosal melanoma cell line,MM9H-1,and defined this cell line as a TWT melanoma subtype lacking well-characterized“driver mutations”.The MM9H-1 cell line could be adopted as a unique model for the preclinical investigation of mucosal melanoma. | Chaoji Shi Ziyue Gu Shengming Xu Houyu Ju Yunteng Wu Yong Han Jiayi Li Chuwen Li Jing Wu Lizhen Wang Jiang Li Guoyu Zhou Weimin Ye Guoxin Ren Zhiyuan Zhang Rong Zhou | 2022 | Cancer Communications2022，42，7： | 1 |
| 15 | Comparisons between the characteristics of ichthyofaunas in nearshore waters of five estuaries with varying degrees of connectivity with the ocean 显示文摘 | HOEKSEMA S D CHUWEN B M POTTER I C | 2009 | Estuarine Coastal and Shelf Science2009，85，1： | 1 |
| 16 | Effect of cavitation on comminution of mica powder显示文摘The cavitation abrasive water jet was used in the comminution of mica. By applying a cavitation nozzle in the abrasive water jet system to enhance the effect of cavitation and friction, better comminution results were obtained. The JME-200CX transmission electron microscope was used for observing the size distribution of particles. As using cavitation abrasive water jet, the relative comminution effect is raised by more than 25% compared with using abrasive water jet only. Itcan be concluded that the effect of cavitation is much more significant than that of impacting in the comminution of mica. | Chuwen Guo, Linsheng Liu, Donghai Zhang, and Kai CuiChina University of Mining & Technology, Xuzhou 221008, China | 2002 | Journal of University of Science and Technology Beijing2002，9，5： | 0 |
| 17 | Advances in aptamer-based nanomaterials for separation and analysis of non-genetic biomarkers in biofluids显示文摘Body fluids contain a large number of disease markers including proteins,exosomes and cells,the concentration of which indicates the health status of a body system and can be hence applied to predict the degree of seriousness of a disease.However,the content of disease markers is relatively low.For solving this problem,a variety of pretreatment methods have been developed,among which aptamer-based nanomaterials hold great potential for biomarker capture because of various natural properties of nano-substrates such as high specific surface area,as well as the high affinity of aptamer towards target and the higher stability than antibody.In this review,we summarized the recent aptamer-based nanomaterials for the separation and analysis of different biomarkers including proteins,exosomes and cells.More specifically,the standard of classification description was based on the applied substrates including magnetic substrates and non-magnetic substrates.Moreover,the perspective of aptamer-based nanomaterials was discussed. | Zidan Wang Chuwen Huang Nianrong Sun Chunhui Deng | 2021 | Science China Chemistry2021，64，6： | 0 |
| 18 | Thermal Performances of High-Temperature Thermal Energy Storage System with Tin Embedded in Copper Matrix by Theoretical Methods显示文摘There is a critical need to develop advanced high-temperature thermal storage systems to improve efficiencies and reduce the costs of solar thermal storage system.In this work,two typical systems composed with Cu as matrix and Sn as the phase change material(PCM)are explored,namely,the 3-deimentional(3D)structure system by embedding Sn particles into Cu matrix and the 2-deimentional(2D)structure system by embedding Sn wires into Cu matrix.Given the thermophysical properties of a nanomaterial could be importantly different from that of a bulk one,we thus firstly derive the thermophysical properties of PCM and matrix theoretically,like the thermal conductivity by kinetic method and the specific heat capacity based on Lindemann’s criterion.And then,these properties are utilized to estimate the energy storage ability in both 3D and 2D structure system,and the influence of structure on heat transfer efficiency is theoretically investigated in both 3D and 2D structure system.Results turn out that 3D structure system is a better choice than a 2D structure system,because of larger specific surface area,a larger sensitive heat capacity and a larger thermal conductivity.When the feature size of the PCM decreases to be less than a critical value which is about 500 nm for Sn,the thermal conductivity of the system decreases exponentially while the heat storage capacity increases lineally.Moreover,when the feature size of Sn geometry is less than a critical value,which is 15 nm for 3D structure system and 25 nm for 2D structure,the Cu matrix can’t play a role in improving the effective thermal conductivity of the whole system. | LAN Yingying HUANG Congliang GUO Chuwen | 2022 | Journal of Thermal Science2022，31，5： | 0 |
| 19 | Anti-Jahn-Teller effect induced ultrafast insulator to metal transition in perovskite BaBiO_(3)显示文摘The Jahn-Teller(JT)effect involves the ions M with a degenerate electronic state distorting the corner-sharing MO_(6)octahedra to lift the degeneracy,inducing strong coupling of electrons to lattice,and mediating the exotic properties in perovskite oxides.Conversely,the anti-Jahn–Teller(AJT)effect refers to the deformation against the Jahn-Teller-distorted MO_(6)octahedra.However,it is difficult to experimentally execute both effects descending from the fine-tuning of crystal structures.We propose the AJT can be introduced by THz laser illumination at 11.71 THz in a candidate superconducting perovskite material BaBiO_(3)near room temperature.The illumination coherently drives the infrared-active phonon that excites the Raman breathing mode through the quadratic-linear nonlinear interaction.The process is characterized by the emergence of an AJT effect,accompanied by an insulator-to-metal transition occurring on the picosecond timescale.This study underlines the important role of crystal structure engineering by coherent phonon excitation in designing optoelectronic devices. | Nan Feng Jian Han Changpeng Lin Zhengwei Ai Chuwen Lan Ke Bi Yuanhua Lin Kan-Hao Xue Ben Xu | 2022 | npj Computational Materials2022，，1： | 0 |
| 20 | Integrated'omics analysis for the gut microbiota response to moxibustion in a rat model of chronic fatigue syndrome显示文摘OBJECTIVE:To observe the efficacy of moxibustion in the treatment of chronic fatigue syndrome(CFS)and explore the effects on gut microbiota and metabolic profiles.METHODS:Forty-eight male Sprague-Dawley rats were randomly assigned to control group(Con),CFS model group(Mod,established by multiple chronic stress for 35 d),MoxA group(CFS model with moxibustion Shenque(CV8)and Guanyuan(CV4),10 min/d,28 d)and MoxB group(CFS model with moxibustion Zusanli(ST36),10 min/d,28 d).Open-field test(OFT)and Morris-water-maze test(MWMT)were determined for assessment the CFS model and the therapeutic effects of moxibustion.16S rRNA gene sequencing analysis based gut microbiota integrated untargeted liquid chromatograph-mass spectrometer(LC-MS)based fecal metabolomics were executed,as well as Spearman correlation analysis,was utilized to uncover the functional relevance between the potential metabolites and gut microbiota.RESULTS:The results of our behavioral tests showed that moxibustion improved the performance of CFS rats in the OFT and the MWMT.Microbiome profiling analysis revealed that the gut microbiomes of CFS rats were less diverse with altered composition,including increases in pro-inflammatory species(such as Proteobacteria)and decreases in anti-inflammatory species(such as Bacteroides,Lactobacillus,Ruminococcus,and Prevotella).Moxibustion partially normalized these changes in the gut microbiota.Furthermore,CFS was associated with metabolic disorders,which were effectively ameliorated by moxibustion.This was demonstrated by the normalization of 33 microbiota-related metabolites,including mannose(P=0.001),aspartic acid(P=0.009),alanine(P=0.007),serine(P=0.000),threonine(P=0.027),methionine(P=0.023),5-hydroxytryptamine(P=0.008),alpha-linolenic acid(P=0.003),eicosapentaenoic acid(P=0.006),hypoxanthine(P=0.000),vitamin B6(P=0.000),cholic acid(P=0.013),and taurocholate(P=0.002).Correlation analysis showed a significant association between the perturbed fecal microbiota and metabolite levels,with a notable negative relationship between LCA and Bacteroides.CONCLUSIONS:In this study,we demonstrated that moxibustion has an antifatigue-like effect.The results from the 16S rRNA gene sequencing and metabolomics analysis suggest that the therapeutic effects of moxibustion on CFS are related to the regulation of gut microorganisms and their metabolites.The increase in Bacteroides and decrease in LCA may be key targets for the moxibustion treatment of CFS. | LI Chaoran YANG Yan FENG Chuwen LI Heng QU Yuanyuan WANG Yulin WANG Delong WANG Qingyong GUO Jing SHI Tianyu SUN Xiaowei WANG Xue HOU Yunlong SUN Zhongren YANG Tiansong | 2023 | Journal of Traditional Chinese Medicine2023，43，6： | 0 |
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