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| 1 | Economic burden and its associated factors of hospitalized patients infected with A (H7N9) virus: a retrospective study in Eastern China, 2013–2014显示文摘Background:H7N9 continues to cause human infections and remains a pandemic concern.Understanding the economic impacts of this novel disease is important for making decisions on health resource allocation,including infectious disease prevention and control investment.However,there are limited data on such impacts.Methods:Hospitalized laboratory-confirmed H7N9 patients or their families in Jiangsu Province of China were interviewed.Patients’direct medical costs of hospitalization were derived from their hospital bills.A generalized linear model was employed to estimate the mean direct medical costs of patients with different characteristics.Results:The mean direct cost of hospitalization for H7N9 was estimated to be¥71060(95%CI,48180–104820),i.e.,US$10996(95%CI,7455–16220),and was¥12060(US$1861),¥136120(US$21001)and¥218610(US$33728)for those who had mild or severe symptoms or who died,respectively.The principal components of the total fees differed among patients with different disease severity,although medication fees were always the largest contributors.Disease severity,proportion of reimbursement and family member monthly average income were identified as the key factors that contributed to a patient’s direct medical cost of hospitalization.Conclusions:The direct medical costs of hospitalized patients with H7N9 are significant,and far surpass the annual per capita income of Jiangsu Province,China.The influencing factors identified should be taken into account when developing related health insurance policies and making health resource allocation.Trial registration:Not applicable.This is a survey study with no health care intervention implemented on human participants. | Xiang Huo Li-Ling Chen Lei Hong Lun-Hui Xiang Fen-Yang Tang Shan-Hui Chen Qiang Gao Cong Chen Qi-gang Dai Chuan-Wu Sun Ke Xu Wen-Jun Dai Xian Qi Chang-Cheng Li Hui-Yan Yu Yin Zhou Hao-Di Huang Xing-Yang Pan Chang-sha Xu Ming-Hao Zhou Chang-Jun Bao | 2016 | Infectious Diseases of Poverty2016，5，1： | 10 |
| 2 | Endothelial CDS2 deficiency causes VEGFA-mediated vascular regression and tumor inhibition显示文摘The response of endothelial cells to signaling stimulation is critical for vascular morphogenesis,homeostasis and function.Vascular endothelial growth factor-a(VEGFA)has been commonly recognized as a pro-angiogenic factor in vertebrate developmental,physiological and pathological conditions for decades.Here we report a novel finding that genetic ablation of CDP-diacylglycerol synthetase-2(CDS2),a metabolic enzyme that controls phosphoinositide recycling,switches the output of VEGFA signaling from promoting angiogenesis to unexpectedly inducing vessel regression.Live imaging analysis uncovered the presence of reverse migration of the angiogenic endothelium in cds2 mutant zebrafish upon VEGFA stimulation,and endothelium regression also occurred in postnatal retina and implanted tumor models in mice.In tumor models,CDS2 deficiency enhanced the level of tumorsecreted VEGFA,which in-turn trapped tumors into a VEGFA-induced vessel regression situation,leading to suppression of tumor growth.Mechanistically,VEGFA stimulation reduced phosphatidylinositol(4,5)-bisphosphate(PIP2)availability in the absence of CDS2-controlled-phosphoinositide metabolism,subsequently causing phosphatidylinositol(3,4,5)-triphosphate(PIP3)deficiency and F0X01 activation to trigger regression of CDS2-null endothelium.Thus,our data indicate that the effect of VEGFA on vasculature is context-dependent and can be converted from angiogenesis to vascular regression. | Wencao Zhao Le Cao Hanru Ying Wenjuan Zhang Dantong Li Xiaolong Ziiu Wenzhi Xue Shuang Wu Mengye Cao Cong Fu Haonan Qi Yimei Hao Yun-Chi Tang Jun Qin Tao PZhong Xiaoxi Lin Luyang Yu Xuri Li Lin Li Dianqing Wu Weijun Pan | 2019 | Cell Research2019，29，11： | 9 |
| 3 | Malnutrition and Quality of Life in Chinese Cancer Patients: a Clinical Study of 23,994 Subjects显示文摘Background Malnutrition is common in patients with cancer,and can negatively impact their quality of life(QoL)and even survival.However,there is currently no large data available on the prevalence of malnutrition in Chinese cancer patients.This study evaluated the prevalence of malnutrition and the QoL of Chinese patients with locoregional,recurrent or metastatic cancer.Methods We conducted a nationwide observational,multi-center,hospital-based cross-sectional study within the Chinese Society of Nutritional Oncology(CSNO)Network.All of the patients were diagnosed with one of the following 18 different types of malignant tumors:lung cancer,gastric cancer,liver cancer,colorectal cancer,breast cancer,esophageal cancer,cervical cancer,endometrial cancer,nasopharyngeal carcinoma,malignant lymphoma,leukemia,pancreatic cancer,ovarian cancer,prostate cancer,bladder cancer,brain cancer,biliary tract malignant tumors or gastrointestinal stromal tumors.These patients were enrolled from 72 hospitals located in different regions of China.The patients’nutritional status was evaluated based on the body mass index(BMI),loss of bodyweight,laboratory measurements and patient generated-subjective global assessment(PG-SGA)scores.The cancer patients’physical status and QoL were assessed by the Karnofsky Performance Status(KPS)questionnaire and the European Organization for Research and Treatment of Cancer(EORTC)QLQ-C30 questionnaire,respectively.Results From December 2013 to April 2016,23,994 patients hospitalized for cancer treatment(such as surgery,chemotherapy or radiotherapy)were enrolled in the study.The patients included 12,494(52.9%)males and 11,124(47.1%)females.The mean age was 55.8±13.7 years.The proportions of patients in cancer stagesⅠ,Ⅱ,Ⅲ,Ⅳand uncertain were 11.5%,20.3%,27.5%,30.2%and 10.5%,respectively.Among the 23,994 inpatients,the proportions of patients who were underweight(BMI<18.5 kg/m2),normal(18.5 kg/m2 | Hong Xia Xu Chun Hua Song Zhen Ming Fu Chang Wang Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun Hua Wang Jing Wu Ying He Jia Jun Yang Cong Hua Xie Fu Xiang Zhou Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Min Weng Qing Hua Yao Jiu Wei Cui Wei Li Han Ping Shi the Investigation on Nutrition Status and Clinical Outcome of Common Cancers(INSCOC)Group | 2021 | Journal of Nutritional Oncology2021，6，1： | 8 |
| 4 | A prospective study of vertical transmission of hepatitis C virus显示文摘AprospectivestudyofverticaltransmissionofhepatitisCvirusSUNDeGui1,LIUCaiYun1,MENGZongDa2,SUNYongDe2,WANGShuCong1,YANGYu... | SUN De Gui 1, LIU Cai Yun 1, MENG Zong Da 2, SUN Yong De 2, WANG Shu Cong 1, YANG Yu Qi 1, LIANG Zheng Lun 3 and ZHUANG Hui 3 | 1997 | World Journal of Gastroenterology1997，3，2： | 8 |
| 5 | No association between low-dose reserpine use and depression in older hypertensive patient: result of a multicenter, cross-sectional study显示文摘Background Reserpine is currently used by millions of Chinese hypertensive patients, in spite of the continued concern of its depressogenic effect, even when used in low dose. This study aimed to investigate the association between low-dose reserpine use and depression in older Chinese hypertensive patient. Methods In this cross-sectional, case-control study, we recruited patient aged 60 years or over who had regularly taken one or two tables of “compound reserpine and triamterene tablets (CRTTs)” for more than one year (reserpine user) from 26 community health centers located in 10 provinces in China. For each patient who took CRTTs, we selected an age (within five years) and sex matched hypertensive patient who had never taken any drugs containing reserpine (non-reserpine user) as control. Depressive symptoms were evaluated using a Chinese depression scale adapted from the Zung Self-Rating Depression Scale. Demographic, clinical data and laboratory examination results within six months were collected. Results From August 2018 to December 2018, 787 reserpine user and 787 non-reserpine user were recruited. The mean age of all study subjects was 70.3 years, with about equal numbers of males and females. The mean depression score was 40.4 in reserpine users and 40.6 in non-reserpine users (P = 0.7). The majority of study subject had a depression score < 53 (87.6% in reserpine users and 88.2% in non-reserpine users, respectively). There were no significant differences in the prevalence of mild, moderate or severe depression in reserpine users and non-reserpine users. Conclusions There is no association between low-dose reserpine use and depression in older hypertensive patient. The role of reserpine in the treatment and control of hypertension should be reconsidered;and further studies, especially randomized, controlled clinical trials to compare efficacy and safety of reserpine and other widely recommended anti-hypertensive agents are needed. | Guo-Hua ZHU Xi-Peng SUN Jing LI Lin PI Hai-Qin TANG Hai-Qing GAO Hong-Liang CONG Peng QU Xin-Zheng LU Xin-Jun ZHANG Luo-Sha ZHAO Yi-Fang GUO Dong-Xia LIU Liang-Qing ZHANG Hua TANG Yi-Xin HU Li FAN Qi HUA | 2019 | Journal of Geriatric Cardiology2019，16，8： | 8 |
| 6 | Research on Water-Exit and Take-off Process for Morphing Unmanned Submersible Aerial Vehicle显示文摘This paper presents a theoretic implementation method of Morphing Unmanned Submersible Aerial Vehicle(MUSAV),which can both submerge in the water and fly in the air.Two different shapes are put forward so that the vehicle can suit both submergence and flight,considering the tremendous differences between hydrodynamic configuration and aerodynamic configuration of a vehicle.The transition of the two shapes can be achieved by using morphing technology.The water-to-air process,including water-exit,morphing,take-off and steady flight,is analyzed.The hydrodynamic and aerodynamic model of the vehicle exiting the water surface obliquely and then taking off into the air has been founded.The control strategy after morphing is analyzed and the control method is given.Numerical method is used to validate the motion model of the water-exit process.Results of simulations show the validity of the proposed model and the feasibility of MUSAV in theory. | HU Jun-hua XU Bao-wei FENG Jin-fu QI Duo YANG Jian WANG Cong | 2017 | China Ocean Engineering2017，31，2： | 8 |
| 7 | A high speed 1000 fps CMOS image sensor with low noise global shutter pixels显示文摘A low read noise 8T global shutter pixel for high speed CMOS image sensor is proposed in this paper.The pixel has a pixel level sample-and-hold circuit and an in-pixel amplifier whose gain is larger than one.Using pixel level sample-and-hold circuit,the KTC noise on FD node can be effectively cancelled by correlated double sampling operation.The in-pixel amplifier with a gain larger than one is employed for reducing the pixel level sample-and-hold capacitors thermal noise and their geometric size.A high speed 1000 fps 256×256 CMOS image sensor based on the pixel is implemented in 0.18μm CMOS process.The chip active area is 5 mm×7 mm with a pixel size of 14μm×14μm.The developed sensor achieves a read noise level as low as 14.8e-while attaining a high fill factor of 40%.The full well capacity can contain 30840e-and the resulting signal dynamic range is 66 dB. | ZHOU YangFan CAO ZhongXiang QIN Qi LI QuanLiang SHI Cong WU NanJian | 2014 | Science China(Information Sciences)2014，57，4： | 8 |
| 8 | FBW7 regulates endothelial functions by targeting KLF2 for ubiquitination and degradation显示文摘F 盒子和 WD 重复包含域 7 (FBW7 ) , E3 ubiquitin ligase SCF FBW7 (SKP1, cullin-1 和 FBW7 的建筑群) ,在各种各样的生理、病理学的过程起重要作用。尽管 FBW7 为脉管的开发被要求,它在内皮细胞层的函数尚待被调查。在这研究,我们证明 FBW7 是 endothelial 功能的一个重要管理者,包括 angiogenesis,白血球粘附和 endothelial 障碍正直。用 RNA 干扰,我们发现 FBW7 的弄空显著地在 vitro 并且在 vivo 损害 angiogenesis。我们识别了锌手指抄写因素 Krü象 ppel 一样因素 2 (KLF2 ) 作为在 endothelial 房间的 FBW7 的一个生理的目标。FBW7 击倒表示在 endothelial 房间导致了内长的 KLF2 蛋白质的累积。调停 FBW7 的 KLF2 破坏被显示在二保存 phosphodegrons 经由肝糖 synthase kinase-3 (GSK3 ) 取决于 KLF2 的 phosphorylation。变异这些 phosphodegron 主题废除了 KLF2 的调停 FBW7 的降级和 ubiquitination。调停 siRNA 显示出的 FBW7 击倒 KLF2 是在 endothelial 的规定的 FBW7 的一个必要目标,这工作。而且,调停 FBW7 的 KLF2 降级被显示为在 teratomas 并且在 zebrafish 开发的 angiogenesis 批评。一起拿,我们的学习在 endothelial 房间移植, angiogenesis,发炎和障碍完整的进程为 FBW7 建议一个角色,并且在 vivo 提供新奇卓见进 KLF2 稳定性的规定。 | Rui Wang Yah Wang Ning Liu Chunguang Ren Cong Jiang Kai Zhang Su Yu Yunfei Chen Hui Tang Qi Deng Cong Fu Yingcong Wang Rong Li Mingyao Liu Weijun Pan Ping Wang | 2013 | Cell Research2013，23，6： | 7 |
| 9 | Fabrication of a Bionic Needle with both Super-Hydrophobic and Antibacterial Properties显示文摘 | Xin Qi Wei Song Zhu Mao Wenran Gao Qian Cong | 2013 | Journal of Bionic Engineering2013，10，3： | 7 |
| 10 | Photolysis of organic pollutants in wastewater with 206 nm UV irradiation显示文摘新型的紫外轻来源(206 nm ) 第一次在废水为器官的污染物质的降级被探索。triphenyltin 氯化物(TPTCl ) 的降级表演,暗淡乙醇 phthalate (DMP ) ,以及玫瑰精 B (RhB ) 被调查。结果显示了 50 mg/L RhB, 60 mg/L DMP 和 120 mg/L TPTCl 的那移动效率能分别地为 60 min, 50 min 和 75 min 到达 88.6% , 92.5% 和 89.4% 。由移动效率的比较,我们发现 206 nm 比在废水处理紫外的 253.7 nm 优异,暗示分解在废水的器官的污染物质是一种有效、有希望、值得的探索技术。 | Zhao Lian Ye Chang Qing Cao Jin Cong He Ren Xi Zhang Hui Qi Hou | 2009 | Chinese Chemical Letters2009，20，6： | 7 |
| 11 | Validity of the Chinese Version of the Patient-Generated Subjective Global Assessment (PG-SGA) in Lung Cancer Patients显示文摘The prevalence of malnutrition is high among oncology patients in China. Although the Patient- Generated Subjective Global Assessment (PG-SGA) is widely recognized as an important nutritional assessment tool, it has not been validated for Chinese cancer patients. The purpose of this study was to conduct an analysis of nutrition screening and assessment data to validate the Chinese version of the PG-SGA in Chinese patients with lung cancer. This was an observational, cross-sectional study of 2,000 consecutive adult patients with lung cancer treated at several tertiary hospitals in China. Anthropometric and patient descriptive data were collected. The PG-SGA generated a score for the nutritional risk and a global rating for the nutritional status. The internal consistency, external consistency, and construct validity were evaluated, and a known-groups comparison and principal component analyses were conducted to evaluate the reliability and validity of the PG-SGA. The known-groups comparison demonstrated the ability of the PG-SGA to differentiate lung cancer patients of different nutritional and body mass index (BMI) groups. A confirmatory factor analysis supported the original four-factor structure of the PG-SGA. In terms of the internal and external consistency, the PG-SGA demonstrated intra-class correlation coefficients (ICC) up to 0.987. Alternative form validity was also demonstrated between Box 4 of the PG-SGA and the Karnofsky Performance Status score, with excellent external consistency (r = 0.972, P < 0.001). The construct validity was supported, and selected questionnaire dimensions were evident in the principal component analysis. Significant Spearman correlations (P < 0.001) were demonstrated. The Chinese version of the PG-SGA demonstrated significant reliability and sufficient exploratory properties to support its validity. It seems to be a valid tool that can be used to access the nutritional status of Chinese lung cancer patients. The validity of the PG-SGA in Chinese cancer patients warrants further investigation in other cancer types. | Zhen Ming Fu Hong Xia Xu Chun Hua Song Wei Li Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun Hua Wang Jing Wu Ying He Jia Jun Yang Cong Hua Xie Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Chang Wang Han Ping Shi The Investigation on Nutrition Status and Clinical Outcome of Common Cancers (INSCOC) Group | 2016 | Journal of Nutritional Oncology2016，1，1： | 7 |
| 12 | Production of thick-walled hollow glass microspheres for inertial confinement fusion targets by sol-gel technology显示文摘To fabricate thick-walled hollow glass microspheres(HGMs)for inertial confinement fusion(ICF)targets by sol-gel technology,we investigated the effects of glass composition,blowing agent,refining temperature,pressure and composition of furnace atmosphere on the wall thickness of HGMs by numerical simulation and experiments.The results showed that the residence times of the thick-walled HGMs in the encapsulating and refining phases decreased with the increase of wall thickness of HGMs.As a response to this challenge,glass composition must be optimized with the object of high surface tension and low viscosity at refining temperature,and the blowing agents with high decomposition temperature should be used,furthermore the concentration of blowing agents in gel particles must also be precisely controlled.The higher volume fraction of argon gas in the furnace atmosphere,the thicker the wall of HGMs.Due to the limited operating range of furnace atmosphere pressure,changing furnace atmosphere pressure could not significantly increase the wall thickness of HGMs.Although increasing refining temperature can improve the yield of high quality HGMs,a higher furnace atmosphere temperature may lead to a decrease in the wall thickness of HGMs.When the volume fraction of argon gas in the furnace atmosphere ranged from 80%to 95%,the furnace atmosphere pressure ranged from 1.0×105Pa to 1.25×105 Pa,and the refining temperature ranged from 1600°C to 1800°C,we produced thick-walled(5–10-m)HGMs with good sphericity,wall thickness uniformity and surface finish.However,the yield of high quality HGMs needs to be further improved.The compressive strength,tensile strength and permeation coefficient to deuterium gas of thick-walled HGMs at ambient temperature decreased with increase of the wall thickness. | GAO Cong QI XiaoBo WEI Sheng ZHANG ZhanWen LI Bo SHI Tao CHU QiaoMei | 2011 | Science China(Technological Sciences)2011，54，9： | 6 |
| 13 | Validity of the Chinese Version of the Patient-Generated Subjective Global Assessment (PG-SGA) in Gastric Cancer Patients显示文摘Purpose Malnutrition is severe among gastric cancer patients in China. While the Patient-Generated Subjective Global Assessment (PG-SGA) is a widely used nutritional assessment tool, the validation for Chinese patients with gastric cancer has not been performed yet. The aim of this research is to validate the Chinese version of the PGSGA in Chinese gastric cancer patients by conducting analyses of nutrition screening and assessment data. Methods Two thousand consecutive adult patients with gastric cancer were included in this observational, cross-sectional study in several tertiary hospitals in China. A survey was made among those patients, which included several questionnaires and some anthropometric parameters. We calculated the parameters to validate the use of PG-SGA categorizing the nutritional status of gastric cancer patients. Then we performed statistical analysis to evaluate the internal consistency, external consistency, and construct validity. Results This study verified the ability of the PG-SGA to differentiate gastric cancer patients into different nutritional groups. The confirmatory factor analysis verified the original four-factor structure of the PG-SGA. The internal and external consistency was measured by a concordance analysis which showed an intraclass correlation coefficients (ICC) of 0.987. The correlations of the Box 4 score with the Karnofsky performance status score demonstrated alternative form validity with good external consistency (Pearson, r = 0.643, P < 0.001). All three anthropometric dimensions of the PG-SGA were supported by principal component analysis. Spearman correlations (P < 0.001) were significant in the majority of tests. Conclusion The Chinese version of the PG-SGA is a valid tool to access the patients’ nutritional status for Chinese gastric patients. | Zhen Ming Fu Hong Xia Xu Chun Hua Song Wei Li Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun Hua Wang Jing Wu Ying He Jia Jun Yang Cong Hua Xie Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Chang Wang Han Ping Shi The Investigation on Nutrition Status and Clinical Outcome of Common Cancers (INSCOC) Group | 2018 | Journal of Nutritional Oncology2018，3，4： | 5 |
| 14 | Trust-based service composition in multi-domain environments under time constraint显示文摘Trust plays a pivotal role in decision support for service-oriented computing networks.Recent advances in service evaluation and selection have provided some preliminary findings on the construction of composite services.However,the great expense of interdomain validations,the dynamic execution time and the subjective requirement for global execution time remain serious obstacles to the trust-based service composition.To solve these issues,this paper proposes a novel service-composition approach,modeling the trust-based service composition as the multi-domain scheduling and assignment problem using the minimum service resources within a certain time constraint.In our approach,each service is designed as an exclusive resource during its execution.By analyzing the required interdomain communications,the number of available services and the aggregated trust value in each domain,the optimal domain can be obtained at each step of service selection.Meanwhile,loop parallelization and predecessor reselection are adopted when the task cannot be completed on schedule.Finally,to raise higher trust value of the composite result,the redundant service resources of the initial composition are further optimized.The experimental results illustrate that the proposed trust-based service-composition approach outperforms traditional ones in both effectiveness and scalability under various time constraints. | ZHANG Tao MA JianFeng LI Qi XI Ning SUN Cong | 2014 | Science China(Information Sciences)2014，57，9： | 5 |
| 15 | Microstructure and Mechanical Properties of Wire + Arc Additively Manufactured 2050 Al–Li Alloy Wall Deposits显示文摘Aluminum–Lithium(Al–Li) alloy is a topic of great interest owing to its high strength and light weight, but there are only a few applications of Al–Li alloy in wire ss, a special AA2050 Al–Li alloy + arc additive manufacturing(WAAM) process. To identify its feasibility in WAAM procewire was produced and employed in the production of straight-walled components, using a WAAM system based on variable polarity gas tungsten arc welding(VP-GTAW) process. The influence of post-deposited heat treatment on the microstructure and property of the deposit was investigated using optical micrographs(OM), scanning electron microscopy(SEM), X-ray diffraction(XRD), hardness and tensile properties tests. Results revealed that the microstructures of AA2050 aluminum deposits varied with their location layers. The upper layers consisted of fine equiaxed grains, while the bottom layer exhibited a coarse columnar structure. Mechanical properties witnessed a significant improvement after post-deposited heat treatment, with the average micro-hardness reaching 141 HV and the ultimate tensile strength exceeding 400 MPa. Fracture morphology exhibited a typical ductile fracture. | Hao Zhong Bojin Qi Baoqiang Cong Zewu Qi Hongye Sun | 2019 | Chinese Journal of Mechanical Engineering2019，32，6： | 4 |
| 16 | CFD-Based Optimization of Hot Primary-Air Pipe Networks in Power Plant Milling Systems显示文摘A hot primary-air pipe system is the bridge connecting an air-preheater with a coal mill in power generation stations.The effective geometrical configuration of the pipe network greatly affects the air flow distribution and consequently influences the safe and economic operation of milling systems in power stations.In order to improve the properties of the air flow,in the present work the SIMPLEC method is used to simulate numerically the flow field for the original layout of the system.As a result,the internal mechanisms influencing the uneven pressure drop in each branch are explored and three optimization schemes are proposed accordingly.The numerical results indicate that,for the original layout,the local pressure drop of the tee section accounts for approximately 74%of the total drop of the system,with other pressure drops depending on the specific branch considered.It is shown that after optimization,a roughly balanced flow resistance and flow rate can be obtained.Compared with the original layout,the pressure drop relating to different branches is significantly reduced. | Qingyun Yan You Li Yuanhong Zhu Kui Cheng Xueli Huang Cong Qi Xuemin Ye | 2020 | Fluid Dynamics & Materials Processing2020，16，3： | 4 |
| 17 | Phosphorus forms and distribution in Zhejiang coastal sediment in the East China Sea显示文摘Surface and core sediment samples were collected from Zhejiang coastal waters of the East China Sea to study phosphorus(P) forms and understand the potential release of P as well as adsorption.The sediments were extracted sequentially to determine four phosphorus fractions,and non-sequentially for total phosphorus(TP).The total concentration of phosphorus in the surface sediments ranged from 527.2 to 680.5 mg kg^(-1).Inorganic P was the major form and accounted for 84-94%of TP.Among the four forms,P-Detrital was dominant(58.6-73.2%),followed by P-CDB(10.5-20.9%),P-Organic(6.1-15.9%),and P-CFA(5.9-16.3%).The distribution pattern of TP in the surface sediments was similar to that of P-Detrital and P-Organic,but different from P-CDB and P-CFA.A relatively high level of phosphorus was observed in estuarine sediments,reflecting the influence from terrestrial input.Phosphorus in all forms in core sediments at each station decreased with depth.In addition,potentially bio-available phosphorus accounted for 20-34%of TP. | Min CONG Tao JIANG Yu-zao QI Hong-po DONG De-qiang TENG Song-hui LU | 2014 | International Journal of Sediment Research2014，29，2： | 4 |
| 18 | Traditional Chinese Medicine Automated Diagnosis Based on Knowledge Graph Reasoning显示文摘Syndrome differentiation is the core diagnosis method of Traditional Chinese Medicine(TCM).We propose a method that simulates syndrome differentiation through deductive reasoning on a knowledge graph to achieve automated diagnosis in TCM.We analyze the reasoning path patterns from symptom to syndromes on the knowledge graph.There are two kinds of path patterns in the knowledge graph:one-hop and two-hop.The one-hop path pattern maps the symptom to syndromes immediately.The two-hop path pattern maps the symptom to syndromes through the nature of disease,etiology,and pathomechanism to support the diagnostic reasoning.Considering the different support strengths for the knowledge paths in reasoning,we design a dynamic weight mechanism.We utilize Naïve Bayes and TF-IDF to implement the reasoning method and the weighted score calculation.The proposed method reasons the syndrome results by calculating the possibility according to the weighted score of the path in the knowledge graph based on the reasoning path patterns.We evaluate the method with clinical records and clinical practice in hospitals.The preliminary results suggest that the method achieves high performance and can help TCM doctors make better diagnosis decisions in practice.Meanwhile,the method is robust and explainable under the guide of the knowledge graph.It could help TCM physicians,especially primary physicians in rural areas,and provide clinical decision support in clinical practice. | Dezheng Zhang Qi Jia Shibing Yang Xinliang Han Cong Xu Xin Liu Yonghong Xie | 2022 | Computers, Materials & Continua2022，，4： | 4 |
| 19 | A low power global shutter pixel with extended FD voltage swing range for large format high speed CMOS image sensor显示文摘A low power 8T global shutter pixel with extended FD voltage swing range is proposed for large format high speed CMOS image sensor. The pixel has a negative threshold reset transistor, two in-pixel source followers, and a sample-and-hold circuit. The in-pixel first source follower is employed for reducing the pixel average current and maximum transient current. The negative threshold reset transistor is applied to extend the voltage swing of FD. Using pixel level sample-and-hold circuit, the k TC noise on FD node can be effectively nullified by correlated double sampling operation. A high speed 1000 fps 256×256 CMOS image sensor is implemented in 0.18 μm CMOS process. Two 10-bit cyclic ADC arrays are integrated in this prototype sensor chip. The active area of the chip is 10 mm×7 mm with a pixel size of 14 μm×14 μm. The developed sensor achieves an average current of 23 n A per pixel, a maximum transit current per pixel as low as 1113 n A, and a large FD voltage swing of 1.78 V. The sensor temporal noise level is 103 e-and full well capacity has 27000 e-which results in 48.3 d B signal dynamic range. | ZHOU YangFan CAO ZhongXiang HAN Ye LI QuanLiang SHI Cong DOU RunJiang QIN Qi LIU Jian WU NanJian | 2015 | Science China(Information Sciences)2015，58，4： | 4 |
| 20 | Severe human infection with a novel avian-origin influenza A(H7N4) virus显示文摘Human infections with influenza H7 subtypes, such as H7N9, have raised concerns worldwide. Here, we report a human infection with a novel influenza A(H7N4) virus. A 68 years-old woman with cardiovascular and cholecystic comorbidities developed rapidly progressed pneumonia with influenza-like-illness as initial symptom, recovered after 23 days-hospitalization including 8 days in ICU. Laboratory indicators for liver and blood coagulation dysfunction were observed. Oseltamivir phosphate, glucocorticoids and antibiotics were jointly implemented, with nasal catheterization of oxygen inhalation for this patient.We obtained the medical records and collected serial respiratory and blood specimens from her. We collected throat, cloacal and/or feces samples of poultry and wild birds from the patient's backyard, neighborhood, local live poultry markets(LPMs) and the nearest lake. All close contacts of the patient were followed up and sampled with throat swabs and sera. Influenza viruses and other respiratory pathogens were tested by real-time RT-PCR, viral culturing and/or sequencing for human respiratory and bird samples. Micro-neutralizing assay was performed for sera. A novel reassortant wild bird-origin H7N4 virus is identified from the patient and her backyard poultry(chickens and ducks) by sequencing, which is distinct from previously-reported avian H7N4 and H7N9 viruses. At least four folds increase of neutralizing antibodies to H7N4 was detected in her convalescent sera. No samples from close contacts, wild birds or other poultry were tested positive for H7N4 by real-time RT-PCR. | Xiang Huo Lun-biao Cui Cong Chen Dayan Wang Xian Qi Ming-hao Zhou Xiling Guo Fengming Wang William J. Liu Weirong Kong Daxin Ni Ying Chi Yiyue Ge Haodi Huang Feifei Hu Chao Li Xiang Zhao Ruiqi Ren Chang-jun Bao George F. Gao Feng-Cai Zhu | 2018 | Science Bulletin2018，63，16： | 4 |
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