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| 1 | A fundamental theorem for eco-environmental surface modelling and its applications显示文摘We propose a fundamental theorem for eco-environmental surface modelling(FTEEM) in order to apply it into the fields of ecology and environmental science more easily after the fundamental theorem for Earth’s surface system modeling(FTESM). The Beijing-Tianjin-Hebei(BTH) region is taken as a case area to conduct empirical studies of algorithms for spatial upscaling, spatial downscaling, spatial interpolation, data fusion and model-data assimilation, which are based on high accuracy surface modelling(HASM), corresponding with corollaries of FTEEM. The case studies demonstrate how eco-environmental surface modelling is substantially improved when both extrinsic and intrinsic information are used along with an appropriate method of HASM. Compared with classic algorithms, the HASM-based algorithm for spatial upscaling reduced the root-meansquare error of the BTH elevation surface by 9 m. The HASM-based algorithm for spatial downscaling reduced the relative error of future scenarios of annual mean temperature by 16%. The HASM-based algorithm for spatial interpolation reduced the relative error of change trend of annual mean precipitation by 0.2%. The HASM-based algorithm for data fusion reduced the relative error of change trend of annual mean temperature by 70%. The HASM-based algorithm for model-data assimilation reduced the relative error of carbon stocks by 40%. We propose five theoretical challenges and three application problems of HASM that need to be addressed to improve FTEEM. | Tianxiang YUE Na ZHAO Yu LIU Yifu WANG Bin ZHANG Zhengping DU Zemeng FAN Wenjiao SHI Chuanfa CHEN Mingwei ZHAO Dunjiang SONG Shihai WANG Yinjun SONG Changqing YAN Qiquan LI Xiaofang SUN Lili ZHANG Yongzhong TIAN Wei WANG Ying’an WANG Shengnan MA Hongsheng HUANG Yimin LU Qing WANG Chenliang WANG Yuzhu WANG Ming LU Wei ZHOU Yi LIU Xiaozhe YIN Zong WANG Zhengyi BAO Miaomiao ZHAO Yapeng ZHAO Yimeng JIAO Ufra NASEER Bin FAN Saibo LI Yang YANG John PWILSON | 2020 | Science China Earth Sciences2020，63，8： | 7 |
| 2 | No expenditure difference among patients with liver cancer at stageⅠ-ⅣV:Findings from a multicenter cross-sectional study in China显示文摘Objective:The number of liver cancer patients in China accounts for more than half of the world.However,China currently lacks national,multicenter economic burden data,and meanwhile,measuring the differences among different subgroups will be informative to formulate corresponding policies in liver cancer control.Thus,the aim of the study was to measure the economic burden of liver cancer by various subgroups.Methods:A hospital-based,multicenter and cross-sectional survey was conducted during 2012・2014,covering 39 hospitals and 21 project sites in 13 provinces across China.The questionnaire covers clinical information,sociology,expenditure,and related variables.All expenditure data were reported in Chinese Yuan(CNY)using 2014 values.Results:A total of 2,223 liver cancer patients were enrolled,of whom 59.61%were late-stage cases(III-IV),and 53.8%were hepatocellular carcinoma.The average total expenditure per liver cancer patient was estimated as 53,220 CNY,including 48,612 CNY of medical expenditures(91.3%)and 4,608 CNY of non-medical expenditures(8.7%).The average total expenditures in stage I,H,m and stage IV were 52,817 CNY,50,877 CNY,50,678 CNY and 54,089 CNY(P>0.05),respectively.Non-medical expenditures including additional meals,additional nutrition care,transportation,accommodation and hired informal nursing were 1,453 CNY,839 CNY,946 CNY,679 CNY and 200 CNY,respectively.The one-year out-of-pocket expenditure of a newly diagnosed patient was 24,953 CNY,and 77.2%of the patients suffered an unmanageable financial burden.Multivariate analysis showed that overall expenditure differed in almost all subgroups(P<0.05),except for sex,clinical stage,and pathologic type.Conclusions:There was no difference in treatment expenditure for liver cancer patients at different clinical stages,which suggests that maintaining efforts on treatment efficacy improvement is important but not enough.To fiirtherly reduce the overall economic burden from liver cancer,more effort should be given to primary and secondary prevention strategies. | Haike Lei Lin Lei Jufang Shi Yongzhong Wu Ling Liang Huiyao Huang Mei He Fangzhou Bai Maomao Cao Hui Qiu Yuting Wang Chengcheng Liu Jia Du Hong Wang Yan Zhang Mengdi Cao Ji Peng Ni Li Chunfeng Qu Min Dai Wanqing Chen Jie He | 2020 | Chinese Journal of Cancer Research2020，32，4： | 7 |
| 3 | Sialic acid-engineered mesoporous polydopamine nanoparticles loaded with SPIO and Fe3+as a novel theranostic agent for T1/T2 dual-mode MRI-guided combined chemo-photothermal treatment of hepatic cancer显示文摘diagnostic and therapeutic capability are highly needed for the treatment of hepatic cancer.Herein,we aimed to develop a novel mesoporous polydopamine(MPDA)-based theranostic agent for T1/T2 dual magnetic resonance imaging(MRI)-guided cancer chemo-photothermal therapy.Superparamagnetic iron oxide(SPIO)-loaded MPDA NPs(MPDA@SPIO)was firstly prepared,followed by modifying with a targeted molecule of sialic acid(SA)and chelating with Fe^(3+)(SA-MPDA@SPIO/Fe^(3+) NPs).After that,doxorubicin(DOX)-loaded SA-MPDA@SPIO/Fe^(3+) NPs(SA-MPDA@SPIO/DOX/Fe^(3+))was prepared for tumor theranostics.The prepared SAPEG-MPDA@SPIO/Fe^(3+) NPs were water-dispersible and biocompatible as evidenced by MTT assay.In vitro photothermal and relaxivity property suggested that the novel theranostic agent possessed excellent photothermal conversion capability and photostability,with relaxivity of being r1=4.29 mM��1s��1 and r2=105.53 mM��1s��1,respectively.SAPEG-MPDA@SPIO/Fe^(3+) NPs could effectively encapsulate the DOX,showing dual pH-and thermal-triggered drug release behavior.In vitro and in vivo studies revealed that SA-MPDA@SPIO/DOX/Fe^(3+) NPs could effectively target to the hepatic tumor tissue,which was possibly due to the specific interaction between SA and the overexpressed E-selectin.This behavior also endowed SA-MPDA@SPIO/DOX/Fe^(3+)NPs with a more precise T1-T2 dual mode contrast imaging effect than the one without SA modification.In addition,SAPEG-MPDA@SPIO/DOX/Fe^(3+) NPs displayed a superior therapeutic effect,which was due to its active targeting ability and combined effects of chemotherapy and photothermal therapy.These results demonstrated that SAPEG-MPDA@SPIO/DOX/Fe^(3+) NPs is an effective targeted nanoplatform for tumor theranostics,having potential value in the effective treatment of hepatic cancer. | Gaofeng Shu Minjiang Chen Jingjing Song Xiaoling Xu Chenying Lu Yuyin Du Min Xu Zhongwei Zhao Minxia Zhu Kai Fan Xiaoxi Fan Shiji Fang Bufu Tang Yiyang Dai Yongzhong Du Jiansong Ji | 2021 | Bioactive Materials2021，6，5： | 4 |
| 4 | Progress of Jinping Underground laboratory for Nuclear Astrophysics(JUNA)显示文摘Jinping Underground laboratory for Nuclear Astrophysics(JUNA) will take the advantage of the ultra-low background of CJPL lab and high current accelerator based on an ECR source and a highly sensitive detector to directly study for the first time a number of crucial reactions occurring at their relevant stellar energies during the evolution of hydrostatic stars. In its first phase, JUNA aims at the direct measurements of^(25)Mg(p,γ)^(26)Al,^(19)F(p,α)^(16)O,^(13)C(α,n)^(16)O and ^(12)C(α,γ)^(16)O reactions. The experimental setup,which includes an accelerator system with high stability and high intensity, a detector system, and a shielding material with low background, will be established during the above research. The current progress of JUNA will be given. | WeiPing Liu ZhiHong Li JiangJun He XiaoDong Tang Gang Lian Zhu An JianJun Chang Han Chen QingHao Chen XiongJun Chen ZhiJun Chen BaoQun Cui XianChao Du ChangBo Fu Lin Gan Bing Guo GuoZhu He Alexander Heger SuQing Hou HanXiong Huang Ning Huang BaoLu Jia LiYang Jiang Shigeru Kubono JianMin Li KuoAng Li Tao Li YunJu Li Maria Lugaro XiaoBing Luo HongYi Ma ShaoBo Ma DongMing Mei YongZhong Qian JiuChang Qin Jie Ren YangPing Shen Jun Su LiangTing Sun WanPeng Tan Isao Tanihata Shuo Wang Peng Wang YouBao Wang Qi Wu ShiWei Xu ShengQuan Yan LiTao Yang Yao Yang XiangQing Yu Qian Yue Sheng Zeng HuanYu Zhang Hui Zhang LiYong Zhang NingTao Zhang QiWei Zhang Tao Zhang XiaoPeng Zhang XueZhen Zhang ZiMing Zhang Wei Zhao Zuo Zhao Chao Zhou | 2016 | Science China(Physics,Mechanics & Astronomy)2016，59，4： | 3 |
| 5 | A cabazitaxel liposome for increased solubility, enhanced antitumor effect and reduced systemic toxicity显示文摘The potential side effects of cabazitaxel(CBZ)in the field of cancer treatment have become a great limitation to its further clinical application.Liposomal delivery is a well-established approach to increase the therapeutic index of hydrophobic drugs.In this study,a PEGmodified liposome was developed for efficiently encapsulating CBZ,thus enhancing its specific tumor inhibition effect and reducing the systemic toxicity.It was found that the loading efficiency of CBZ into the liposome could be improved with the increase of lipophilic materials,as it could be over 80%under the weight ratio of 20:1(total lipid:CBZ).The diameter of CBZ loaded liposome(CBZ@Lipo)was^100 nm.And the liposome suspending in aqueous medium was stable at 4°C for at least one month,according to the change of its size distribution.The killing ability of CBZ@Lipo to cancer cells was significantly lower comparing to that of CBZ solution,which could be attributed to the slow release of CBZ from the liposomes.However,CBZ@Lipo could induce an obvious apoptosis of the cancer cells at low concentration.Furthermore,CBZ@Lipo exhibited an expressively enhanced tumor growth inhibition effect comparing to CBZ solution.More importantly,CBZ@Lipo showed an obviously higher biosafety proved by lower hemolysis probability,stable body weight of mice during the whole experiment and no obvious lesion in histology analysis.Our work provided a useful reference of the formulation of CBZ,which had potential for greater clinical application. | Xiaoyi Yin Lihua Luo Wei Li Jie Yang Chunqi Zhu Mengshi Jiang Bing qin Xiaoling Yuan Hang Yin Yichao Lu Yongzhong Du Dawei Chen Jian You | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，6： | 3 |
| 6 | Altitude pattern of carbon stocks in desert grasslands of an arid land region显示文摘For estimating the altitude-distribution pattern of carbon stocks in desert grasslands and analyzing the possible mechanism for this distribution, a detailed study was performed through a series of field vegetation surveys and soil samplings from 90 vegetation plots and 45 soil profiles at 9 sites of the Hexi Corridor region, Northwestern China. Aboveground, belowground, and litter-fall biomass-carbon stocks ranged from 43 to 109, 23 to 64, and 5 to 20 g/m2, with mean values of 80.82,44.91, and 12.15 g/m2, respectively. Soil-carbon stocks varied between 2.88 and 3.98 kg/m2, with a mean value of 3.43 kg/m2 in the 0–100-cm soil layer. Both biomass-and soil-carbon stocks had an increasing tendency corresponding to the altitudinal gradient. A significantly negative correlation was found between soil-carbon stock and mean annual temperature, with further better correlations between soil-and biomass-carbon stocks, and mean annual precipitation. Furthermore, soil carbon was found to be positively correlated with soil-silt and-clay content, and negatively correlated with soil bulk density and the volume percent of gravel. It can be concluded that variations in soil texture and climate condition were the key factors influencing the altitudinal pattern of carbon stocks in this desert-grassland ecosystem. Thus, by using the linear-regression functions between altitude and carbon stocks, approximately 4.18 Tg carbon were predicted from the 1,260 km2 of desert grasslands in the study area. | Rong Yang JunQia Kong ZeYu Du YongZhong Su | 2018 | Research in Cold and Arid Regions2018，10，5： | 2 |
| 7 | Synthesis and antitumor activity of doxorubicin conjugated stea- ricacid-g-chitosan oligosaccharide polymeric micelles显示文摘 | Hu Fuqiang Liu Lina Du Yongzhong | 2009 | Biomaterials2009，30，36： | 1 |
| 8 | Preparation and characteristics of hydroxypropyl - β - cyelodextrin polymeric nanocapsules loading nimodipine 显示文摘 | DU Yongzhong XU Jiaguo WANG Ling | 2009 | European Polymer Journal2009，45，5： | 1 |
| 9 | Preparation and characteristics of nanostructured lipid carriers for control - releasing progesterone by melt - emulsification 显示文摘 | ~YUAN HONG WANG LEILEI DU YONGZHONG | 2007 | Colloids and Surfaces B : Biointerfaces2007，60，2： | 1 |
| 10 | Effects of conditions for preparing nanoparticles composed of aminoethylearbamoyl-β-cyelodextrin and ethylene glycol diglycidyl ether on trap efficiency of a guest molecule显示文摘 | Masaru Eguchi Du Yongzhong Yoshikatsu Ogawa | 2006 | Int J Pharm2006，311，12： | 1 |
| 11 | Preparation and characteristics of monostearin nanostruetured lipid carriers 显示文摘 | HU FUQIANG JIANG SAIPING DU YONGZHONG | 2006 | International Journal of Pharmaeeuties2006，314，1： | 1 |
| 12 | Preparation and characteristics of nanostructured lipid carriers for control - releasing progesterone by melt - emulsification 显示文摘 | YUAN HONG WANG LEILEI DU YONGZHONG | 2007 | Colloids and Surfaces B : Biointerfaces2007，60，2： | 1 |
| 13 | Preparation and characterization of stearic acid nanostructured lipid carriers by solvent diffusion method in an aqueous system显示文摘 | HU FUQIANG JIANG SAIPING DU YONGZHONG | 2005 | Colloids and Surfaces B : Biointerfaces2005，45，3： | 1 |
| 14 | 显示文摘 | Ni Henmei Du Yongzhong Ma Guanghui | 2001 | Macromolecules2001，34，： | 1 |
| 15 | Morphological studies in thermally initiated emulsion (co)polymerization without conventional initiators 显示文摘 | Du Yongzhong Ma Guanghui Ni Henmei | 2002 | J Appl Polym Sci2002，84，9： | 1 |
| 16 | Recent advances in nanotherapeutics for the treatment and prevention of acute kidney injury显示文摘Acute kidney injury(AKI)is a serious kidney disease without specific medications currently except for expensive dialysis treatment.Some potential drugs are limited due to their high hydrophobicity,poor in vivo stability,low bioavailability and possible adverse effects.Besides,kidney-targeted drugs are not common and small molecules are cleared too quickly to achieve effective drug concentrations in injured kidneys.These problems limit the development of pharmacological therapy for AKI.Nanotherapeutics based on nanotechnology have been proved to be an emerging and promising treatment strategy for AKI,which may solve the pharmacological therapy dilemma.More and more nanotherapeutics with different physicochemical properties are developed to efficiently deliver drugs,increase accumulation and control release of drugs in injury kidneys and also directly as effective antioxidants.Here,we discuss the recent nanotherapeutics applied in the treatment and prevention of AKI with improved effectiveness and few side effects. | Hui Yu Di Liu Gaofeng Shu Feiyang Jin Yongzhong Du | 2021 | Asian Journal of Pharmaceutical Sciences2021，16，4： | 1 |
| 17 | Mechanism of Soap-Free Emulsion Polymerization of Styrene and 4-Vinylpyridine Characteristics of Reaction in the Monomer Phase, Aqueous Phase, and Their Interface显示文摘 | Henmei Ni Yongzhong Du | 2001 | Macromolecules2001，34，： | 1 |
| 18 | Mechanism of soap-free emulsion polymerization of styrene and 4-vinylpyridine characteristics of reaction in the monomer phase,aqueous phase,and their interface显示文摘 | Henmei Ni Yongzhong Du | 2001 | Micromolecules2001，34，： | 1 |
| 19 | Synthesis of hemispherical poly (2-hydroxylethyl methacrylate-co-methyl methacrylate)/poly (styrene-co-glycidyl methacrylate) composite particles with heterobifunctional groups by soap-free seeded emulsion polymerization显示文摘 | DU Yongzhong TOMOHIRO T KODAKA M | 2004 | Macromolecules2004，37，3： | 1 |
| 20 | Polymeric micelles with glycolipid-like structure and multiple hydrophobic domains for mediating molecular targetdelivery of paclitaxel显示文摘 | YOU Jian HU Fuqiang DU Yongzhong | 2007 | Biomacromolecules2007，8，8： | 1 |
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