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| 1 | MicroRNA-663 induces immune dysregulation by inhibiting TGF-β1 production in bone marrow-derived mesenchymal stem cells in patients with systemic lupus erythematosus显示文摘Mesenchymal stem cells(MSCs)are critical for immune regulation.Although several microRNAs(miRNAs)have been shown to participate in autoimmune pathogenesis by affecting lymphocyte development and function,the roles of miRNAs in MSC dysfunction in autoimmune diseases remain unclear.Here,we show that patients with systemic lupus erythematosus(SLE)display a unique miRNA signature in bone marrow-derived MSCs(BMSCs)compared with normal controls,among which miR-663 is closely associated with SLE disease activity.MiR-663 inhibits the proliferation and migration of BMSCs and impairs BMSC-mediated downregulation of follicular T helper(Tfh)cells and upregulation of regulatory T(Treg)cells by targeting transforming growth factorβ1(TGF-β1).MiR-663 overexpression weakens the therapeutic effect of BMSCs,while miR-663 inhibition improves the remission of lupus disease in MRL/lpr mice.Thus,miR-663 is a key mediator of SLE BMSC regulation and may serve as a new therapeutic target for the treatment of lupus. | Linyu Geng Xiaojun Tang Kangxing Zhou Dandan Wang Shiying Wang Genhong Yao Weiwei Chen Xiang Gao Wanjun Chen Songtao Shi Nan Shen Xuebing Feng Lingyun Sun | 2019 | Cellular & Molecular Immunology2019，16，3： | 16 |
| 2 | Combined remediation of DDT congeners and cadmium in soil by Sphingobacterium sp.D-6 and Sedum alfredii Hance显示文摘Combined pollution of 1,1,1-trichloro-2,2-bis (4-chlorophenyl) ethane (DDT) and cadmium (Cd) in agricultural soils is of great concern because they present serious risk to food security and human health.In order to develop a cost-effective and safe method for the removal of DDTs and Cd in soil,combined remediation of DDTs and Cd in soil by Sphingobacterium sp.D-6 and the hyperaccumulator,Sedum alfredii Hance was investigated.After treatment for 210 days,the degradation half-lives of DDTs in soils treated by strain D-6 decreased by 8.1% to 68.0% compared with those in the controls.The inoculation of strain D-6 into soil decreased the uptake of DDTs by pak choi and S.alfredii.The shoots/roots ratios of S.alfredii for the Cd accumulation ranged from 12.32 to 21.75.The Cd concentration in soil decreased to 65.8%-71.8% for S.alfredii treatment and 14.1%-58.2% for S.alfredii and strain D-6 combined treatment,respectively,compared with that in the control.The population size of the DDTs-degrading strain,Simpson index (1/D) and soil respiratory rate decreased in the early stage of treatment and then gradually increased,ultimately recovering to or exceeding the initial level.The results indicated that synchronous incorporation of strain D-6 and S.alfredii into soil was found to significantly (p 0.05) enhance the degradation of DDTs in soil and the hyperaccumulation of Cd in S.alfredii.It was concluded that strain D-6 and S.alfredii could be used successfully to control DDTs and Cd in contaminated soil. | Hua Fang Wei Zhou Zhengya Cao Feifan Tang Dandan Wang Kailin Liu Xiangwei Wu Xiao'e Yang Yongge Sun Yunlong Yu | 2012 | Journal of Environmental Sciences2012，24，6： | 5 |
| 3 | Effects of alkalinity on interaction between EPS and hydroxy-aluminum with different speciation in wastewater sludge conditioning with aluminum based inorganic polymer flocculant显示文摘Extracellular polymeric substances(EPS)form a stable gel-like structure to combine with water molecules through steric hindrance,making the mechanical dewatering of wastewater sludge considerably difficult.Coagulation/flocculation has been widely applied in improving the sludge dewatering performance,while sludge properties(organic fraction and solution chemistry conditions)are highly changeable and have important effects on sludge flocculation process.In this work,the alkalinity effects on sludge conditioning with hydroxy-aluminum were comprehensively investigated,and the interaction mechanisms between EPS and hydroxy-aluminum with different speciation were unraveled.The results showed that the effectiveness of hydroxy-aluminum conditioning gradually deteriorated with increase in alkalinity.Meanwhile,the polymeric hydroxy-aluminum(Al 13)and highly polymerized hydroxy-aluminum(Al 30)were hydrolysed and converted into amorphous aluminum hydroxide(Al(OH)3),which changed the flocculation mechanism from charge neutralization and complexing adsorption to hydrogen bond interaction.Additionally,both Al 13 and Al 30 showed higher binding capacity for proteins and polysaccharides in EPS than monomeric aluminum and Al(OH)3.Al 13 and Al 30 coagulation changed the secondary structure of proteins in EPS,which caused a gelation reaction to increase molecular hydrophobicity of proteins and consequently sludge dewaterability.This study provided a guidance for optimizing the hydroxy-aluminum flocculation conditioning of sludge with high solution alkalinity. | Weijun Zhang Mingyue Tang Dandan Li Peng Yang Shiwei Xu Dongsheng Wang | 2021 | Journal of Environmental Sciences2021，33，2： | 5 |
| 4 | Atmospheric deposition of inorganic nitrogen in a semi-arid grassland of Inner Mongolia, China显示文摘Due to increasing global demand for crop production and energy use, more and more reactive nitrogen(Nr) has been generated and emitted to the environment. As a result, global atmospheric nitrogen(N) deposition has tripled since the industrial revolution and the ecological environment and human health have been harmed. In this study, we measured dry and wet/bulk N deposition from July 2013 to December 2015 in a semi-arid grassland of Duolun County, Inner Mongolia, China. The samples of dry and wet/bulk N deposition were collected monthly with a DELTA(DEnuder for Long Term Atmospheric sampling) system and with Gradko passive samplers and a precipitation gauge. The measured results show that the annual mean concentrations of NH_3, NO_2, HNO_3, particulate NH_4^+(pNH_4^+) and particulate NO_3^-(pNO_3^-) in atmosphere were 2.33, 1.90, 0.18, 1.42 and 0.42 μg N/m3, respectively, and that the annual mean volume-weighted concentrations of NH_4^+-N and NO_3^--N in precipitation were 2.71 and 1.99 mg N/L, respectively. The concentrations of Nr components(including NH_3, NO_2, HNO_3, p NH_4^+, pNO_3^-, NH_4^+-N and NO_3^--N) exhibited different seasonal variations. Specifically, NO_2 and HNO_3 exhibited higher concentrations in autumn than in summer, while the other Nr components(NH_3, pNH_4^+, pNO_3^-, NH_4^+-N and NO_3^--N) showed the highest values in summer. Based on measured concentrations of Nr components and their deposition velocities estimated using the GEOS-Chem global atmospheric chemical transport model, the calculated annual mean dry deposition fluxes were 3.17, 1.13, 0.63, 0.91 and 0.36 kg N/(hm^2·a) for NH_3, NO_2, HNO_3, p NH_4^+ and pNO_3^-, respectively, and the calculated annual mean wet/bulk deposition fluxes were 5.37 and 3.15 kg N/(hm^2·a) for NH_4^+-N and NO_3^--N, respectively. The estimated annual N deposition(including dry N deposition and wet/bulk N deposition) reached 14.7 kg N/(hm^2·a) in grassland of Duolun County, approaching to the upper limit of the N critical load(10–15 kg N/(hm^2·a)). Dry and wet/bulk deposition fluxes of all Nr components(with an exception of HNO_3) showed similar seasonal variations with the maximum deposition flux in summer and the minimum in winter. Reduced Nr components(e.g., gaseous NH_3 and p NH_4^+ in atmosphere and NH_4^+-N in precipitation) dominated the total N deposition at the sampling site(accounted for 64% of the total N deposition), suggesting that the deposited atmospheric Nr mainly originated from agricultural activities. Considering the projected future increases in crop and livestock production in Inner Mongolia, the ecological and human risks to the negative effects of increased N deposition could be increased if no mitigation measures are taken. | ZHANG Yibo XU Wen WEN Zhang WANG Dandan HAO Tianxiang TANG Aohan LIU Xuejun | 2017 | Journal of Arid Land2017，9，6： | 5 |
| 5 | 18beta-glycyrrhetinic acid induces ROS-mediated apoptosis to ameliorate hepatic fibrosis by targeting PRDX1/2 in activated HSCs显示文摘Hepatic stellate cells(HSCs)are essential drivers of fibrogenesis.Inducing activated-HSC apoptosis is a promising strategy for treating hepatic fibrosis.18beta-glycyrrhetinic acid(18b-GA)is a natural compound that exists widely in herbal medicines,such as Glycyrrhiza uralensis Fisch,which is used for treating multiple liver diseases,especially in Asia.In the present study,we demonstrated that 18b-GA decreased hepatic fibrosis by inducing the apoptosis in activated HSCs.18b-GA inhibited the expression of a-smooth muscle actin and collagen type Ⅰ alpha-1.Using a chemoproteomic approach derived from activity-based protein profiling,together with cellular thermal shift assay and surface plasmon resonance,we found that 18b-GA covalently targeted peroxiredoxin 1(PRDX1)and peroxiredoxin 2(PRDX2)proteins via binding to active cysteine residues and thereby inhibited their enzymatic activities.18b-GA induced the elevation of reactive oxygen species(ROS),resulting in the apoptosis of activated HSCs.PRDX1 knockdown also led to ROS-mediated apoptosis in activated HSCs.Collectively,our findings revealed the target proteins and molecular mechanisms of 18b-GA in ameliorating hepatic fibrosis,highlighting the future development of 18b-GA as a novel therapeutic drug for hepatic fibrosis. | Qian Zhang Piao Luo Liuhai Zheng Jiayun Chen Junzhe Zhang Huan Tang Dandan Liu Xueling He Qiaoli Shi Liwei Gu Jiahao Li Qiuyan Guo Chuanbin Yang Yin Kwan Wong Fei Xia Jigang Wang | 2022 | Journal of Pharmaceutical Analysis2022，12，4： | 3 |
| 6 | Effects of Angelica sinensis extracts on lipid oxidation in fish feeds and growth performance of juvenile Jian carp(Cyprinus carpio var. Jian)显示文摘The study was to explore the effect of the extracts of Angelica sinensis(EAs) on lipid oxidation in fish feeds compared with ethoxyquin(EQ) and the effect of dietary EAs on growth performance of carp(Cyprinus carpio var. Jian). Firstly, fish feeds were respectively added with EQ, and ethyl ether extract ethyl acetate extract(EAE), acetone extract, ethanol extract(EE) and aqueous extract(AQE) of Angelica sinensis, except for the control. The results showed that EAs and EQ inhibited lipid oxidation in fish feed(P < 0.05). Of all of the examined EAs, EAE showed the strongest protective effects against lipid oxidation(P < 0.05). Moreover, EAE at high concentrations showed a stronger effect on lipid oxidation compared with EQ(P < 0.05). Then, 7 experimental diets respectively supplemented with 0.0, 1.0, 2.0, 3.0, 4.0, 5.0 and 6.0 g/kg of EAE were fed to the respective treatment groups for 30 d. Four replicates were performed for each treatment group; 20 carp(mean weight: 12.10 ± 0.13 g) were in each replicate. The result indicated that dietary EAE improved the growth performance in carp(P < 0.05). The appropriate con centration of EAE for carp growth was estimated to be 3.643 g/kg diet. Thus, EAE could be used as a natural antioxidant in feeds for Jian carp. | Huatao Li Dandan Yang Zhihao Li Mingquan He Fengyi Li Jun Jiang Siyi Tang Peiyuan Peng Wenhao Du Yuting Ma Ying Liu | 2019 | Animal Nutrition2019，，1： | 2 |
| 7 | A comprehensive analysis of the Bencao(herbal)small RNA Atlas reveals novel RNA therapeutics for treating human diseases显示文摘Cross-kingdom herbal mi RNA was first reported in 2012.Using a modified herbal extraction protocol,we obtained 73,677,287sequences by RNA-seq from 245 traditional Chinese Medicine(TCM),of which 20,758,257 were unique sequences.We constructed a Bencao(herbal)small RNA(s RNA)Atlas(http://bencao.bmicc.cn),annotated the sequences by sequence-based clustering,and created a nomenclature system for Bencao s RNAs.The profiles of 21,757 mi RNAs in the Atlas were highly consistent with those of plant mi RNAs in mi RBase.Using software tools,our results demonstrated that all human genes might be regulated by s RNAs from the Bencao s RNA Atlas,part of the predicted human target genes were experimentally validated,suggesting that Bencao s RNAs might be one of the main bioactive components of herbal medicines.We established roadmaps for oligonucleotide drugs development and optimization of TCM prescriptions.Moreover,the decoctosome,a lipo-nano particle consisting of 0.5%–2.5%of the decoction,demonstrated potent medical effects.We propose a Bencao(herbal)Index,including small-molecule compounds(SM),protein peptides(P),nucleic acid(N),non-nucleic and non-proteinogenic large-molecule compounds(LM)and elements from Mendeleev's periodic table(E),to quantitatively measure the medical effects of botanic medicine.The Bencao s RNA Atlas is a resource for developing gene-targeting oligonucleotide drugs and optimizing botanical medicine,and may provide potential remedies for the theory and practice of one medicine. | Yinghao Cao Yexuan Lin Na Sun Xinyi Du Yixin Dong Song Mei Xingyu Deng Xiaobei Li Shaoting Guo Kegong Tang Jiaqi Liu Xiangyu Qiao Dandan Zhao Yuhao Qin Cong Zhang Tianyi Xin Xiaohu Shi Congzhao Zhou Tao Dong De-an Guo Benedikt MKessler Dong Xu Jingyuan Song Fengming Huang Xiaoyue Wang Chengyu Jiang | 2023 | Science China(Life Sciences)2023，66，10： | 2 |
| 8 | Synthesis of multifunctional ABC stars with a reduction-labile arm by consecutive ROP, RAFT and ATRP processes显示文摘This study aims at versatile synthesis of 3-arm ABC-type(A=poly(?-caprolactone), PCL; B=poly(N-isopropylacrylamide), PNIPAM; C=poly(tert-butyl acrylate), Pt BA, or poly(acrylic acid), PAA) miktoarm star copolymers with a reducible disulfide linkage. Using 2-((2-((2-hydroxymethyl-2-((2-bromo-2-methyl)propionyloxy)methyl)propionyloxy)ethyl)disulfanyl)ethyl 4-cyano-4-(phenylcarbonothioylthio)pentanoate(HBCP) as a heterotrifunctional initiator, consecutive ring-opening polymerization(ROP) of ?-caprolactone(CL), reversible addition-fragmentation chain transfer(RAFT) polymerization of N-isopropylacrylamide(NIPAM) and atom transfer radical polymerization(ATRP) of tert-butyl acrylate(t BA) afforded ABC1 star, and followed by a subsequent hydrolysis to give ABC2 star. 1H nuclear magnetic resonance(1H NMR) and gel permeation chromatography(GPC) analyses revealed the desired stars and their precursors had well-controlled molecular weight and relatively low polydispersity(PDI?1.12). As confirmed by GPC analysis, the disulfide linkage in ABC1 star could be efficiently cleaved upon reductive stimulus, during which the topology was converted from star terpolymer to mixtures of homopolymer(B) and diblock copolymer(AC1). In addition to acting as nanocarriers for stimuli-triggered drug delivery systems, ABC stars with terminal bromide, dithiobenzoate and hydroxyl functionalities are expected to form other reduction-cleavable multicomponent copolymers such as(BC-graft-A)m and dendritic graft copolymers via postpolymerization modification. Our research affords a straightforward 'core-first' method to construct multifunctional star terpolymers with stimuli-responsive arms and reduction-labile linkage. | Huanhuan Liu Dandan Tang Rupei Tang Youliang Zhao | 2015 | Science China Chemistry2015，58，11： | 2 |
| 9 | What makes Haloxylon persicum grow on sand dunes while H. ammodendron grow on interdune lowlands: a proof from reciprocal transplant experiments显示文摘Determining the mechanisms underlying the spatial distribution of plant species is one of the central themes in biogeography and ecology. However, we are still far from gaining a full understanding of the autecological processes needed to unravel species distribution patterns. In the current study, by comparing seedling recruitment, seedling morphological performance and biomass allocation of two Haloxylon species, we try to identify the causes of the dune/interdune distribution pattern of these two species. Our results show the soil on the dune had less nutrients but was less saline than that of the interdune; with prolonged summer drought, soil water availability was lower on the dune than on the interdune. Both species had higher densities of seedlings at every stage of recruitment in their native habitat than the adjacent habitat. The contrasting different adaptation to nutrients, salinity and soil water conditions in the seedling recruitment stage strongly determined the distribution patterns of the two species on the dune/interdune. Haloxylon persicum on the dunes had lower total dry biomass, shoot and root dry biomass, but allocated a higher percentage of its biomass to roots and possessed a higher specific root length and specific root area by phenotypic traits specialization than that of Haloxylon ammodendron on the interdune. All of these allowed H. persicum to be more adapted to water stress and nutrient shortage. The differences in morphology and allocation facilitated the ability of these two species to persist in their own environments. | GuiQing XU DanDan YU JiangBo XIE LiSong TANG Yan LI | 2014 | Journal of Arid Land2014，6，5： | 2 |
| 10 | Defensive physiological characters of Pyropia yezoensis resistant lines to the red rot disease显示文摘To explore ef fective physiological indexes to distinguish the resistant lines and susceptible lines of Pyt hium porphyrae,the causal agent of red rot disease of Pyropia yezoensis,and establish the disease-resistance breeding strategy,we obtained and analyzed the candidate resistant and susceptible lines by population selection.Gametophytes of the candidate lines were cultured in seawater containing Pyt.porphyrae zoospores.Antioxidase activities,including superoxide dismutase(SOD),peroxidase(POD)and polyphenol oxidase(PPO),were measured and compared between the two lines before and after infection.In the resistant lines,SOD and POD activities increased and then decreased,but PPO activity rose with the prolongation of the infection time.The phenylalanine ammonia lyase(PAL)activities also increased and then decreased after infection,but it had significantly different expression in the two lines without pathogen attack.The synthesis rates ofβ-1,3-glucanase,and cell-wall degrading enzyme were different from each other between the two lines after infection of P yt.porphyrae.Comparison in the contents of malondialdehyde(MDA)and reactive oxygen species(ROS)in the two lines showed that,the two contents varied synchronously in response to the pathogen attack.Changes of these enzymes activities or contents demonstrated that Pyr.yezoensis could resist against the pathogen of P yt.porphyrae with the antioxidant defense capacity.In addition,β-1.3-glucanase content showed extremely significant dif ference between the two lines,and the PAL had consistent expression dif ference.Therefore,phenylalanine ammonia lyase(PAL)andβ-1,3-glucanase can be considered as an ef fective index to distinguish susceptible line and resistant line,with which the workload of the resistant breeding could be reduced in the future. | ZOU Dandan TANG Xianghai QIU Liping MAO Yunxiang | 2020 | Journal of Oceanology and Limnology2020，38，2： | 1 |
| 11 | Single cell analysis reveals inhibition of angiogenesis attenuates the progression of heterotopic ossification in Mkx^(−/−)mice显示文摘Tendon heterotopic ossification(HO)is characterized by bone formation inside tendon tissue,which severely debilitates people in their daily life.Current therapies fail to promote functional tissue repair largely due to our limited understanding of HO pathogenesis.Here,we investigate the pathological mechanism and propose a potential treatment method for HO.Immunofluorescence assays showed that the Mohawk(MKX)expression level was decreased in human tendon HO tissue,coinciding with spontaneous HO and the upregulated expression of osteochondrogenic and angiogenic genes in the tendons of Mkx^(−/−)mice.Single-cell RNA sequencing analyses of wild-type and Mkx^(−/−)tendons identified three cell types and revealed the excessive activation of osteochondrogenic genes during the tenogenesis of Mkx^(−/−)tendon cells.Single-cell analysis revealed that the gene expression program of angiogenesis,which is strongly associated with bone formation,was activated in all cell types during HO.Moreover,inhibition of angiogenesis by the small-molecule inhibitor BIBF1120 attenuated bone formation and angiogenesis in the Achilles tendons of both Mkx mutant mice and a rat traumatic model of HO.These findings provide new insights into the cellular mechanisms of tendon HO and highlight the inhibition of angiogenesis with BIBF1120 as a potential treatment strategy for HO. | Junxin Lin Yuwei Yang Wenyan Zhou Chao Dai Xiao Chen Yuanhao Xie Shan Han Huanhuan Liu Yejun Hu Chenqi Tang Varitsara Bunpetch Dandan Zhang Yishan Chen Xiaohui Zou Di Chen Wanlu Liu Hongwei Ouyang | 2022 | Bone Research2022，10，4： | 1 |
| 12 | Spatial and temporal distribution of Mo in the overlying water of a reservoir downstream from mining area显示文摘This study aimed to evaluate the spatial and temporal variations of molybdenum(Mo)in the downstream water body of a Mo mine during three hydrologic periods(wet,dry and medium seasons).The physical properties in Luhun Reservoir reflected seasonal variations in different hydrological periods.The redox potential(ORP)and dissolved oxygen(DO)increased in the dry season.The concomitant decrease in temperature(T),conductivity(COND)and total dissolved solids(TDS)were lowest in the wet season.The p H value did not change significantly during the three hydrologic periods.The distribution of Mo in the dry season was high in upstream and low in downstream areas,which was significantly different from that of the wet and medium seasons.The total Mo concentration in wet(150.1μg/L)and medium season(148.2μg/L)was higher than that in the dry season,but the TDS(288.3 mg/L)and the percentage dissolved Mo(81.3%)in overlying water was lowest in the wet season.There was no significant relationship between the dissolved Mo and the total Mo with TDS.In the dry season,the mean total Mo concentration was 116.3μg/L,which was higher than the standard limit value(70μg/L)for drinking water(US EPA-United States Environmental Protection Agency recommended value 40μg/L).Non-point source pollution is the main characteristic of mining area pollution,which was closely related to rainfall.Thus,the Luhun Reservoir contains substantial Mo pollution,which was a significant concern given that it is used as a source of drinking and irrigation water. | Zhixin Song Gangfu Song Wenzhong Tang Yu Zhao Dandan Yan Weilong Zhang | 2021 | Journal of Environmental Sciences2021，33，4： | 1 |
| 13 | Single-Cell Exome Sequencing Reveals Single-Nucleotide Mutation Characteristics of a Kidney Tumor显示文摘 | Xun Xu Yong Hou Xuyang Yin Li Bao Aifa Tang Luting Song Fuqiang Li Shirley Tsang Kui Wu Hanjie Wu Weiming He Liang Zeng Manjie Xing Renhua Wu Hui Jiang Xiao Liu Dandan Cao Guangwu Guo Xueda Hu Yaoting Gui Zesong Li Wenyue Xie Xiaojuan Sun Min Shi Zhiming | 2012 | Cell2012，，5： | 1 |
| 14 | A specific phar-macophore model of sodium-dependent glucose co-transporter 2(SGLT2) inhibitors显示文摘 | Chunlei Tang Xiaoyun Zhu Dandan Huang | 2012 | J Mol Model2012，18，6： | 1 |
| 15 | Orally administered BZL-s RNA-20 oligonucleotide targeting TLR4 effectively ameliorates acute lung injury in mice显示文摘The global COVID-19 pandemic emerged at the end of December 2019.Acute respiratory distress syndrome(ARDS)and acute lung injury(ALI)are common lethal outcomes of bacterial lipopolysaccharide(LPS),avian influenza virus,and SARS-Co V-2.Toll-like receptor 4(TLR4)is a key target in the pathological pathway of ARDS and ALI.Previous studies have reported that herbal small RNAs(s RNAs)are a functional medical component.BZL-s RNA-20(Accession number:B59471456;Family ID:F2201.Q001979.B11)is a potent inhibitor of Toll-like receptor 4(TLR4)and pro-inflammatory cytokines.Furthermore,BZLs RNA-20 reduces intracellular levels of cytokines induced by lipoteichoic acid(LTA)and polyinosinic-polycytidylic acid(poly(I:C)).We found that BZL-s RNA-20 rescued the viability of cells infected with avian influenza H5N1,SARS-Co V-2,and several of its variants of concern(VOCs).Acute lung injury induced by LPS and SARS-Co V-2 in mice was significantly ameliorated by the oral medical decoctosome mimic(bencaosome;sphinganine(d22:0)+BZL-s RNA-20).Our findings suggest that BZLs RNA-20 could be a pan-anti-ARDS/ALI drug. | Dandan Zhao Yuhao Qin Jiaqi Liu Kegong Tang Shuaiyao Lu Zirui Liu Yexuan Lin Cong Zhang Fengming Huang Jiahui Chang Chang Li Mingyao Tian Yiming Ma Xiaoyun Li Congzhao Zhou Xiao Li Xiaozhong Peng Ningyi Jin Chengyu Jiang | 2023 | Science China(Life Sciences)2023，66，7： | 1 |
| 16 | Interdiffusion and atomic mobility studies in Ni-rich fcc Ni?Al?Mn alloys显示文摘 | Kaiming Cheng Dandan Liu Lijun Zhang Yong Du Shuhong Liu Chengying Tang | 2013 | Journal of Alloys and Compounds2013，，： | 1 |
| 17 | Discovery of New Thioviridamide-Like Compounds with Antitumor Activities显示文摘Thioviridamide is a structurally unique compound with potent antitumor activity.The biosynthesis of thioviridamide follows a typical pathway as ribosomally synthesized and post-transiationally modified peptides,making the genome mining-based discovery of thioviridamide-like compounds rational.Taking advantage of the linkage between the precursor peptide and the metabolite skeleton,we identified a new biosynthetic gene cluster in Streptomyces sp.NRRL S-87 that could encode thioviridamide analogues.Overexpression of the whole gene cluster led to the isolation and structure elucidation of TVA-YJ-4 and TVA-YJ-5,two novel thioviridamide-like compounds featuring N-terminal capping groups.Chemical screening of the fermentation extracts also detected TVA-YJ-6,another new thioviridamide-like compound with representative methionine sulfoxide.Detailed analysis further revealed that these structural modifications were introduced during the compound extraction process instead of through genuine enzymatic reactions.TVA-YJ-4 and TVA-YJ-5 display slightly reduced cytotoxic activities against a panel of tumor cell lines in comparison with their parental natural product,TVA-YJ-2.Our work will expand the membership of this rare class of compounds and promote related biosynthetic studies. | Yuqing Li Jingyu Liu Haoyu Tang Yanping Qiu Dandan Chen Wen Liu | 2019 | Chinese Journal of Chemistry2019，37，10： | 1 |
| 18 | Hydrogen selenide,a vital metabolite of sodium selenite,uncouples the sulfilimine bond and promotes the reversal of liver fibrosis显示文摘Sodium selenite has alleviating effects on liver fibrosis;however,its therapeutic molecular mechanism remains unclear.Herein,hydrogen selenide,a major metabolite of Na_(2)SeO_(3),was tested to uncouple the sulfilimine bond in collagen IV,the biomarker of liver fibrosis.A mouse model of liver fibrosis was constructed via a CCl_(4)-induced method,followed by the administration of 0.2 mg kg−1 Na_(2)SeO_(3)via gavage three times per week for 4 weeks.Changes in H2Se,NADPH,and H_(2)O_(2)levels were monitored in real time by using NIR-H2Se,DCI-MQ-NADPH,and H_(2)O_(2)probes in vivo,respectively.H_(2)Se continuously accumulated in the liver throughout the Na_(2)SeO_(3)treatment period,but the levels of NADPH and H_(2)O_(2)decreased.The expression of collagen IV was analyzed through Western blot and liquid chromatography-mass spectrometry.Results confirmed that the sulfilimine bond of collagen IV in the fibrotic mouse livers could be broken by H2Se with the Na_(2)SeO_(3)treatment.Therefore,the therapeutic effect of Na_(2)SeO_(3)on liver fibrosis could be mainly attributed to H_(2)Se that uncoupled the sulfilimine bond to induce collagen IV degradation.This study provided a reasonable explanation for the molecular mechanism of the in vivo function of Na_(2)SeO_(3)and the prevention of liver fibrosis by administering inorganic selenium. | Dongrui Luan Zengteng Zhao Dandan Xia Qiuling Zheng Xiaonan Gao Kehua Xu Bo Tang | 2021 | Science China(Life Sciences)2021，64，3： | 1 |
| 19 | Determining cadmium bioavailability in sediment profiles using diffusive gradients in thin films显示文摘Cadmium(Cd)uptake by plants or benthic organisms largely depends on its bioavailability in sediments,so it is necessary to understand Cd bio availability for determining its ecological risks in riverine sediments.Pore water is easily disturbed during sample collection,indicating that there was a shortage of traditional methods for investigating Cd bio availability.Here,sediment cores were collected from rivers,after which sequential extraction and diffusive gradients in thin films(DGT)method were employed to determine Cd potential bio availability in the sediments and pore water.We found that Cd concentrations measured by DGT were lower than that in pore water profiles,and Cd distribution in various fractions changed remarkably.Pearson correlation analysis showed significant positive correlations between Cd concentrations measured by DGT and total Cd concentrations(r^2=0.76),exchangeable and weak acid soluble fraction(r^2=0.68),ferromanganese fraction(r^2=0.72)and bound organic matter or oxidizable fraction(r^2=0.54).However,the correlation was relatively low between Cd concentrations measured by DGT and that in pore water profiles(r^2=0.26).These results demonstrated that DGT method could provide more accurate information of Cd bio availability in sediment profiles than traditional methods. | Zhixin Song Gangfu Song Wenzhong Tang Dandan Yan Minghai Han Baoqing Shan | 2020 | Journal of Environmental Sciences2020，32，5： | 1 |
| 20 | Brassinosteroids regulate outer ovule integument growth in part via the control of INNER NO OUTER by BRASSINOZOLE‐RESISTANT family transcription factors显示文摘Brassinosteroids(BRs)play important roles in regulating plant reproductive processes.BR signaling or BR biosynthesis null mutants do not produce seeds under natural conditions,but the molecular mechanism underlying this infertility is poorly understood.In this study,we report that outer integument growth and embryo sac development were impaired in the ovules of the Arabidopsis thaliana BR receptor null mutant bri1-116.Gene expression and RNA-seq analyses showed that the expression of INNER NO OUTER(INO),an essential regulator of outer integument growth,was significantly reduced in the bri1-116 mutant.Increased INO expression due to overexpression or increased transcriptional activity of BRASSINAZOLE-RESISTANT 1(BZR1)in the mutant alleviated the outer integument growth defect in bri1-116 ovules,suggesting that BRs regulate outer integument growth partially via BZR1-mediated transcriptional regulation of INO.Meanwhile,INO expression in bzr-h,a null mutant for all BZR1 family genes,was barely detectable;and the outer integument of bzr-h ovules had much more severe growth defects than those of the bri1-116 mutant.Together,our findings establish a new role for BRs in regulating ovule development and suggest that BZR1 family transcription factors might regulate outer integument growth through both BRI1-dependent and BRI1-independent pathways. | Dandan Jia Lian-Ge Chen Guimin Yin Xiaorui Yang Zhihua Gao Yi Guo Yu Sun Wenqiang Tang | 2020 | Journal of Integrative Plant Biology2020，62，8： | 1 |
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