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| 1 | Preliminary Scientific Results of Chang'E-1 Lunar Orbiter:Based on Payloads Detection Data in the First Phase显示文摘Chang'E-1 lunar Orbiter was launched by Long March 3A rocket from Xichang Satel-lite Launch Center at 18:05BT(Beijing Time) Oct.24,2007.It is the first step of its ambitious three-stage moon program,a new milestone in the Chinese space exploration history.The primary science objectives of Chang'E-1 lunar orbiter are to obtain three-Dimension(3D) stereo images of the lunar surface,to analyze the distribution and abundance of elements on the surface,to investigate the thickness of lunar soil,evaluate helium-3 resources and other characteristics,and to detect the space environment around the moon.To achieve the above four mission objectives,eight sets of scientific instruments are chosen as the payloads of the lunar orbiter,including a CCD stereo camera(CCD),a Sagnac-based interferometer spectrometer(ⅡM),a Laser Altimeter(LAM),a Microwave Radiometer(MRM),a Gamma-Ray Spectrometer(GRS),an X-ray spectrometer(XRS),a High-Energy Particle Detector(HPD),and two Solar Wind Ion Detectors(SWID).The detected data of the payloads show that all payloads work well.This paper introduces the status of payloads in the first phase and preliminary scientific results. | OUYANG Ziyuan JIANG Jingshan LI Chunlai SUN Huixian ZOU Yongliao LIU Jianzhong LIU Jianjun ZHAO Baochang REN Xin YANG Jianfeng ZHANG Wenxi WANG Jianyu MOU Lingli CHANG Jin ZHANG Liyan WANG Huanyu LI Yongquan ZHANG Xiaohui ZHENG Yongchun WANG Shijin BIAN Wei | 2008 | 空间科学学报2008，28，5： | 24 |
| 2 | Geologic characteristics, controlling factors and hydrocarbon accumulation mechanisms of China’s Large Gas Provinces of low porosity and permeability显示文摘Based on the analysis of the geological characteristics and controlling factors, we analyzed the formation mechanism of different types of gas reservoirs. The main characteristics of gas provinces with low porosity and permeability are mainly as follows: large area, low abundance, small gas pools and large gas provinces; widely distributed excellent hydrocarbon source rocks with closely contacted source-reservoir-cap association; development mainly in large continental depressions or in paralic shallow-river delta systems; many kinds of traps coexisting in large areas, dominantly para-layered lithologic, digenetic and capillary pressure traps; double fluid flow mechanisms of Darcy flow and non-Darcy flow; complicated gas and water relations; and having the resource distribution of highly productive 'sweet spots', banding concentration, and macroscopically large areas integrated. The main controlling factors of large sandstone gas provinces with low porosity and permeability are stable dynamic backgrounds and gentle structural frameworks which control the extensive distribution of alternate (interbedded) sandstones and mudstones; weak hydropower of large gentle lake basins controlling the formation of discontinuous, low porosity and permeability reservoirs in shallow-water deltas; regionally differential diagenesis and no homogeneous digenetic facies controlling the development of favorable reservoirs and digenetic traps; and weak and dispersive reservoir-forming dynamic forces leading to the widely distributed small traps with low abundance. Low porosity and permeability gas provinces with different trap types have different formation mechanisms which include fluid diversion pressure difference interactive mechanism of lithologic-trap gas accumulations, separated differential collection mechanism of digenetic-trap gas accumulations, and the Non-Darcy flow mechanism of capillary-pressure gas accumulations. | ZOU CaiNeng TAO ShiZhen ZHANG XiangXiang HE DongBo ZHOU ChuanMin GAO XiaoHui | 2009 | Science China Earth Sciences2009，52，8： | 22 |
| 3 | Simultaneous virus identification and characterization of severe unexplained pneumonia cases using a metagenomics sequencing technique显示文摘Many viruses can cause respiratory diseases in humans.Although great advances have been achieved in methods of diagnosis,it remains challenging to identify pathogens in unexplained pneumonia(UP) cases.In this study,we applied next-generation sequencing(NGS) technology and a metagenomic approach to detect and characterize respiratory viruses in UP cases from Guizhou Province,China.A total of 33 oropharyngeal swabs were obtained from hospitalized UP patients and subjected to NGS.An unbiased metagenomic analysis pipeline identified 13 virus species in 16 samples.Human rhinovirus C was the virus most frequently detected and was identified in seven samples.Human measles virus,adenovirus B 55 and coxsackievirus A10 were also identified.Metagenomic sequencing also provided virus genomic sequences,which enabled genotype characterization and phylogenetic analysis.For cases of multiple infection,metagenomic sequencing afforded information regarding the quantity of each virus in the sample,which could be used to evaluate each viruses' role in the disease.Our study highlights the potential of metagenomic sequencing for pathogen identification in UP cases. | Xiaohui Zou Guangpeng Tang Xiang Zhao Yan Huang Tao Chen Mingyu Lei Wenbing Chen Lei Yang Wenfei Zhu Li Zhuang Jing Yang Zhaomin Feng Dayan Wang Dingming Wang Yuelong Shu | 2017 | Science China(Life Sciences)2017，60，3： | 14 |
| 4 | Chang'E-1 Lunar Mission:An Overview and Primary Science Results显示文摘Chang'E-1 is the first lunar mission in China,which was successfully launched on Oct.24th,2007.It was guided to crash on the Moon on March 1,2009,at 52.36°E,1.50°S,in the north of Mare Fecunditatis.The total mission lasted 495 days,exceeding the designed life-span about four months.1.37Terabytes raw data was received from Chang'E-1.It was then processed into 4Terabytes science data at different levels.A series of science results have been achieved by analyzing and applicating these data,especially 'global image of the Moon of China's first lunar exploration mission'.Four scientific goals of Chang'E-1 have been achieved.It provides abundant materials for the research of lunar sciences and cosmochemistry.Meanwhile these results will serve for China's future lunar missions. | Ouyang Ziyuan Li Chunlai Lu Chang Liu Jianzhong Zou Yongliao Zhang Hongbo Jianjun Zuo Wei Su Yah Wen Weibin Bian Wei Zhao Baochang Wang Jianyu Yang Jianfeng Chang Jin Wang Huanyu Zhang Xiaohui Wang Shijin Wang Min Ren Xin Mu Lingli Kong Deqing Wang Xiaoqian Wang Fang Geng Liang Zhang Zhoubin Zheng Lei Zhu Xinying Zheng Yongchun Li Junduo Zou Xiaoduan Xu Chun Shi Shuobiao Gao Yifei Gao Guannan | 2010 | 空间科学学报2010，30，5： | 11 |
| 5 | Geological and Geochemical Characteristics and Exploration Prospect of Coal-Derived Tight Sandstone Gas in China: Case Study of the Ordos, Sichuan, and Tarim Basins显示文摘This work extensively investigated global tight sandstone gas, and geologically and geochemically analyzed the tight sandstone gas in China's Ordos, Sichuan, and Tarim basins. We compared typical tight sandstone gas in China with that in North America. We proposed six conditions for the formation of China's tight sandstone gas, and illustrated the geological characteristics of tight sandstone gas. In China, gas-bearing tight sandstones were mainly deposited in continental lake deltas and marine-terrigenous facies basin environments, associated with coal-measure strata, and were mostly buried deeper than 2000 m under a formation pressure of 20–30 MPa, with pressure coefficients varying from overpressure to negative pressure. In other countries, tight gas bearing sandstones were dominantly deposited in marine to marine-terrigenous facies environments, occurred in coal-measure strata, and were mostly buried shallower than 2000 m in low-pressure systems. We systematically analyzed tight sandstone gas in the Ordos, Sichuan, and Tarim basins in terms of chemical compositions, geochemical characteristics of carbon isotopes, origins, and sources. Tight sandstone gas in China usually has a hydrocarbon content of >95%, with CH4 content >90%, and a generally higher dry coefficient. In the three above-mentioned large tight sandstone gas regions, δ13 C1 and δ13 C2 mainly ranges from-42‰ to-28‰ and from-28‰ to-21‰, respectively. Type III coal-measure source rocks that closely coexist with tight reservoirs are developed extensively in these gas regions. The organic petrology of source rocks and the carbon isotope compositions of gas indicate that tight sandstone gas in China is dominantly coal-derived gas generated by coal-measure strata. Our analysis of carbon isotope series shows that local isotope reversals are mainly caused by the mixing of gases of different maturities and that were generated at different stages. With increasing maturity, the reversal tendency becomes more apparent. Moreover, natural gas with medium-low maturity(e.g., Xujiahe Formation natural gas in the Sichuan Basin) presents an apparent reversal at a low-maturity stage, a normal series at a medium-maturity stage, and a reversal tendency again at a high-maturity stage. Finally, we proposed four conditions for preferred tight sandstone gas 'sweep spots,' and illustrated the recoverable reserves, proven reserves, production, and exploration prospects of tight sandstone gas. The geological and geochemical characteristics, origins, sources, and exploration potential of tight sandstone gas in China from our research will be instructive for the future evaluation, prediction, and exploration of tight sandstone gas in China and abroad. | ZOU Caineng TAO Shizhen HAN Wenxue ZHAO Zhenyu MA Weijiao LI Changwei BAI Bin GAO Xiaohui | 2018 | Acta Geologica Sinica(English Edition)2018，92，4： | 11 |
| 6 | Olivine-norite rock detected by the lunar rover Yutu-2 likely crystallized from the SPA-impact melt pool显示文摘Chang’E-4 landed in the South Pole-Aitken(SPA)basin,providing a unique chance to probe the composition of the lunar interior.Its landing site is located on ejecta strips in Von Karm´an crater that´possibly originate from the neighboring Finsen crater.A surface rock and the lunar regolith at 10 sites along the rover Yutu-2 track were measured by the onboard Visible and Near-Infrared Imaging Spectrometer in the first three lunar days of mission operations.In situ spectra of the regolith have peak band positions at 1 and 2μm,similar to the spectral data of Finsen ejecta from the Moon Mineralogy Mapper,which confirms that the regolith’s composition of the landing area is mostly similar to that of Finsen ejecta.The rock spectrum shows similar band peak positions,but stronger absorptions,suggesting relatively fresh exposure.The rock may consist of 38.1±5.4%low-Ca pyroxene,13.9±5.1%olivine and 48.0±3.1%plagioclase,referred to as olivine-norite.The plagioclase-abundant and olivine-poor modal composition of the rock is inconsistent with the origin of the mantle,but representative of the lunar lower crust.Alternatively,the rock crystallized from the impact-derived melt pool formed by the SPA-impact event via mixing the lunar crust and mantle materials.This scenario is consistent with fast-cooling thermal conditions of a shallow melt pool,indicated by the fine to medium-sized texture(<3 mm)of the rock and the SPA-impact melting model[Icarus 2012;220:730–43]. | Honglei Lin Zhiping He Wei Yang Yangting Lin Rui Xu Chi Zhang Meng-Hua Zhu Rui Chang Jinhai Zhang Chunlai Li Hongyu Lin Yang Liu Sheng Gou Yong Wei Sen Hu Changbin Xue Jianfeng Yang Jie Zhong Xiaohui Fu Weixing Wan Yongliao Zou | 2020 | National Science Review2020，7，5： | 9 |
| 7 | Introduction to the Payloads and the Initial Observation Results of Chang'E-1显示文摘Chang'E-1,the orbiter circling the moon 200km above the moon surface,is the first Chinese Lunar exploration satellite.The satellite was successfully launched on 24th October 2007.There are 8 kinds of scientific payloads onboard,including the stereo camera,the laser altimeter,the Sagnac-based interferometer image spectrometer,the Gamma ray spectrometer,the X-ray spectrom-eter,the microwave radiometer,the high energy particle detector,the solar wind plasma detector and a supporting payload data management system.Chang'E-1 opened her eyes to look at the moon and took the first batch of lunar pictures after her stereo camera was switched on in 20th November 2007.Henceforth all the instruments are successfully switched on one by one.After a period of parameter adjustment and initial check out,all scientific instruments are now in their normal operating phase.In this paper,the payloads and the initial observation results are introduced. | SUN Huixian WU Ji DAI Shuwu ZHAO Baochang SHU Rong CHANG Jin WANG Huanyu ZHANG Xiaohui REN Qiongying CHEN Xiaomin OUYANG Ziyuan ZOU Yongliao | 2008 | 空间科学学报2008，28，5： | 4 |
| 8 | Set-Membership Filtering Subject to Impulsive Measurement Outliers:A Recursive Algorithm显示文摘This paper is concerned with the set-membership filtering problem for a class of linear time-varying systems with norm-bounded noises and impulsive measurement outliers.A new representation is proposed to model the measurement outlier by an impulsive signal whose minimum interval length(i.e.,the minimum duration between two adjacent impulsive signals)and minimum norm(i.e.,the minimum of the norms of all impulsive signals)are larger than certain thresholds that are adjustable according to engineering practice.In order to guarantee satisfactory filtering performance,a so-called parameter-dependent set-membership filter is put forward that is capable of generating a time-varying ellipsoidal region containing the true system state.First,a novel outlier detection strategy is developed,based on a dedicatedly constructed input-output model,to examine whether the received measurement is corrupted by an outlier.Then,through the outcome of the outlier detection,the gain matrix of the desired filter and the corresponding ellipsoidal region are calculated by solving two recursive difference equations.Furthermore,the ultimate boundedness issue on the time-varying ellipsoidal region is thoroughly investigated.Finally,a simulation example is provided to demonstrate the effectiveness of our proposed parameter-dependent set-membership filtering strategy. | Lei Zou Zidong Wang Hang Geng Xiaohui Liu | 2021 | IEEE/CAA Journal of Automatica Sinica2021，8，2： | 3 |
| 9 | Copolymerization-Assisted Preparation of Porous LiMn_2O_4 Hollow Microspheres as High Power Cathode of Lithium-ion Batteries显示文摘Porous LiMn2O4 hollow microspheres were facilely prepared by incorporation of Li and Mn elements into a spherical polymeric precursor through copolymerization of lithium and manganese acetates with resorcinol and hexamethylenetetramine and then burning off the organic matrix at appropriate temperatures in air. The LiMn_2O_4 inherited the spherical morphology of the polymeric precursor but showed hollow porous structure assembled by nanocrystals of about 50–100 nm in size. When tested as cathode of Li-ion batteries, the LiMn_2O_4 hollow spheres exhibited excellent rate capability and cycle stability.A discharge capacity of above 90 mAhg^(-1)was maintained at 10 C(1C = 120 mAg^(-1)), and the cells can still deliver a discharge capacity over 100 mAhg^(-1)after another 115 cycles at 0.5 C. With such excellent electrochemical properties, the prepared LiMn_2O_4 hollow microspheres could be promising cathode of Li-ion batteries for long term and high power applications. | Zhimin Zou Zhaojin Li Hui Zhang Xiaohui Wang Chunhai Jiang | 2017 | Journal of Materials Science & Technology2017，33，8： | 2 |
| 10 | SFRP5 inhibits melanin synthesis of melanocytes in vitiligo by suppressing the Wnt/b-catenin signaling显示文摘Secreted frizzled-related protein 5(SFRP5)plays a pivotal role in regulating the development of many tissues and organs,however,as an inhibitor of Wnt signaling,the role of SFRP5 in vitiligo remains unknown.Hence,we speculated that SFRP5 might be associated with melanogenesis in melanocytes by regulating Wnt signaling in vitiligo.In this study,we found that SFRP5 was overexpressed in the skin lesions of patients with vitiligo.Compared with that in normal epidermal melanocytes(PIG1),the expression of SFRP5 was increased in vitiligo melanocytes(PIG3V).To investigate the effect of SFRP5 on melanin synthesis,PIG1 cells were infected with recombinant SFRP5 adenovirus(AdSFRP5),and PIG3V cells were infected with recombinant siSFRP5 adenovirus(AdsiSFRP5).The results showed that SFRP5 overexpression inhibited melanin synthesis in PIG1 cells through downregulation of microphthalmia-associated transcription factor(MITF)and its target proteins via suppression of the Wnt/b-catenin signaling pathway.Accordingly,SFRP5 silencing increased melanin synthesis and activated the Wnt signaling pathway in PIG3V cells.Moreover,SFRP5 overexpression also downregulated the transcriptional activity of T cell factor/lymphoid enhancer factor(TCF/LEF)in PIG1 cells.Furthermore,this inhibitory effect of SFRP5 on melanin synthesis was reversed by treatment with the b-catenin agonist,SKL2001.The inhibitory action of SFRP5 in pigmentation was further confirmed in vivo using a nude mouse model.Hence,our results indicate that SFRP5 can inhibit melanogenesis in melanocytes.Additionally,our findings showed that SFRP5 plays a vital role in the development of vitiligo,and thus may serve as a potential therapeutic target for vitiligo. | Daopei Zou Yangmei Chen Lingzhao Zhang Xiaohui Yuan Yujie Zhang Adelina Inggawati Pham Thi Kieu Nguyet Tianwen Gao Jin Chen | 2021 | Genes & Diseases2021，8，5： | 2 |
| 11 | Phosphorylation of a wheat aquaporin at two sites enhances both plant growth and defense显示文摘Eukaryotic aquaporins share the characteristic of functional multiplicity in transporting distinct substrates and regulating various processes,but the underlying molecular basis for this is largely unknown.Here,we report that the wheat(Triticum aestivum)aquaporin TaPIP2;10 undergoes phosphorylation to promote photosynthesis and productivity and to confer innate immunity against pathogens and a generalist aphid pest.In response to elevated atmospheric CO_(2)concentrations,TaPIP2;10 is phosphorylated at the serine residue S280 and thereafter transports CO_(2)into wheat cells,resulting in enhanced photosynthesis and increased grain yield.In response to apoplastic H_(2)O_(2) induced by pathogen or insect attacks,TaPIP2;10 is phosphorylated at S121 and this phosphorylated form transports H_(2)O_(2) into the cytoplasm,where H_(2)O_(2)intensifies host defenses,restricting further attacks.Wheat resistance and grain yield could be simultaneously increased by TaPIP2;10 overexpression or by expressing a TaPIP2;10 phosphomimic with aspartic acid substitutions at S121 and S280,thereby improving both crop productivity and immunity. | Kai Lu Xiaochen Chen Xiaohui Yao Yuyan An Xuan Wang Lina Qin Xiaoxu Li Zuodong Wang Shuo Liu Zhimao Sun Liyuan Zhang Lei Chen Baoyan Li Baoyou Liu Weiyang Wang Xinhua Ding Yonghua Yang Meixiang Zhang Shenshen Zou Hansong Dong | 2022 | Molecular Plant2022，15，11： | 2 |
| 12 | Optimization of the Extraction Process of Astaxanthin from Haematococcus pluvialis with Oil Dissolution Method显示文摘[Objective] This study aimed to optimize the extraction process of astaxanthin from Haematococcus pluvialis with oil dissolution method. [Method]Small amounts of acetone or ethanol were separately added into soybean oil for astaxanthin extraction. The extraction efficiency of astaxanthin from H. pluvialis with different methods was compared. [Result]The extraction efficiency of astaxanthin from H. pluvialis with acetone,acetone + soybean oil,ethanol + soybean oil,soybean oil was 20. 46,21. 65,20. 85 mg/g and 13. 05 mg/g,respectively. According to the results,acetone + soybean oil led to the highest extraction rate,which was approximately twice that of soybean oil and higher than that of acetone. [Conclusion] This study laid the foundation for large-scale production of astaxanthin. | Xiaohui LI Ning ZOU Donghong SUN Jun ZHANG | 2015 | Agricultural Biotechnology2015，4，6： | 2 |
| 13 | Sirolimus combined with oseltamivir and corticosteroid treatment for a puerpera with severe pneumonia caused by 2009 pandemic H1N1:A case report显示文摘Severe pneumonia in patients infected with the 2009 pandemic H1N1(pH1N1)virus was partially attributed to excessive immune response.Anti-virus treatment for these patients was insufficient.Here we reported the therapy effect of sirolimus,an immunosuppressor,combined with oseltamivir and corticosteroid for a puerpera with severe pneumonia caused by pH1N1 virus.This patient has infected with the pH1N1 virus in late pregnancy,and antiviral therapy was not implemented timely.She developed severe pneumonia and ARDS rapidly and need receive a cesarean section on the 39th week after pregnancy.After giving birth to a healthy baby,she received a combination of oseltamivir,sirolimus and corticosteroid,and improved in the following days.Moreover,the cytokines in serum and viral loads in BALF decreased significantly.She recovered without infectious symptoms and was discharged.Sirolimus combined with oseltamivir and corticosteroid is likely responsible for lowering the viral loads,reducing the patient's cytokine level,and further improving her clinical outcomes.It provides evidence that adjuvant treatment was beneficial to patients with severe pneumonia induced by the pH1N1 virus. | Lijun Suo Xiaofeng Yu Yongfeng Hu Hongyun Cao Xiaohui Zou Peiquan Wang Tao Xu Xiangzhi Zhou Yexin Wu Lili Ren Bo Liu Bin Cao | 2021 | Biosafety and Health2021，3，6： | 2 |
| 14 | Evaluation of ventilation performance and energy efficiency of greenhouse fans显示文摘In order to investigate fan performance in fan-ventilated greenhouses(Urbana,USA),the effects of guard screen and loose belts on fan ventilation airflow and power consumption in greenhouse operations were examined with four belt-driven fans as trial subjects.The Fans Assessment Numeration System was used to measure the airflow rate.Temperature,relative humidity and power consumption were also monitored.Results show there were significant differences in the airflow rate between the fans with a cleaned and uncleaned guard screen(P<0.05).Power consumption also differed significantly even with the same cooling effect in greenhouse.When fan belts were adjusted to the proper tension,the fan speed and airflow rate were 13.1% and 30.1% higher than those of original belts,respectively.The daily average power consumption for the fan with the original loose belts was 20.4% higher than that with the adjusted belts when the pad was not working and 24.2% higher with pad working.The ventilation performance of fans with identical specifications showed a variation by up to 13.0% in terms of the ventilating efficiency ratio.These results demonstrated that fans should be cleaned routinely,and belt tension should be checked to ensure that fan performance meets specifications.This can reduce the power consumption in greenhouses for environmental control.Moreover,reordering fan staging,so that the most efficient fans are used in areas of greatest demand,can also reduce ventilation energy costs. | Zhang Zhi Richard S Gates Zou Zhirong Hu Xiaohui | 2015 | International Journal of Agricultural and Biological Engineering2015，8，1： | 2 |
| 15 | Clinical factors associated with composition of lung microbiota and important taxa predicting clinical prognosis in patients with severe community-acquired pneumonia显示文摘Few studies have described the key features and prognostic roles of lung microbiota in patients with severe community-acquired pneumonia(SCAP).We prospectively enrolled consecutive SCAP patients admitted to ICU.Bronchoscopy was performed at bedside within 48 h of ICU admission,and 16S rRNA gene sequencing was applied to the collected bronchoalveolar lavage fluid.The primary outcome was clinical improvements defined as a decrease of 2 categories and above on a 7-category ordinal scale within 14 days following bronchoscopy.Sixty-seven patients were included.Multivariable permutational multivariate analysis of variance found that positive bacteria lab test results had the strongest independent association with lung microbiota(R2=0.033;P=0.018),followed by acute kidney injury(AKI;R2=0.032;P=0.011)and plasma MIP-1βlevel(R2=0.027;P=0.044).Random forest identified that the families Prevotellaceae,Moraxellaceae,and Staphylococcaceae were the biomarkers related to the positive bacteria lab test results.Multivariable Cox regression showed that the increase inα-diversity and the abundance of the families Prevotellaceae and Actinomycetaceae were associated with clinical improvements.The positive bacteria lab test results,AKI,and plasma MIP-1βlevel were associated with patients’lung microbiota composition on ICU admission.The families Prevotellaceae and Actinomycetaceae on admission predicted clinical improvements. | Sisi Du Xiaojing Wu Binbin Li Yimin Wang Lianhan Shang Xu Huang Yudi Xia Donghao Yu Naicong Lu Zhibo Liu Chunlei Wang Xinmeng Liu Zhujia Xiong Xiaohui Zou Binghuai Lu Yingmei Liu Qingyuan Zhan Bin Cao | 2022 | Frontiers of Medicine2022，16，3： | 2 |
| 16 | A new approach for data clustering using hybrid artificial bee colony algorithm显示文摘 | Xiaohui Yan Yunlong Zhu Wenping Zou Liang Wang | 2012 | Neurocomputing2012，，： | 1 |
| 17 | Single cell analysis reveals inhibition of angiogenesis attenuates the progression of heterotopic ossification in Mkx^(−/−)mice显示文摘Tendon heterotopic ossification(HO)is characterized by bone formation inside tendon tissue,which severely debilitates people in their daily life.Current therapies fail to promote functional tissue repair largely due to our limited understanding of HO pathogenesis.Here,we investigate the pathological mechanism and propose a potential treatment method for HO.Immunofluorescence assays showed that the Mohawk(MKX)expression level was decreased in human tendon HO tissue,coinciding with spontaneous HO and the upregulated expression of osteochondrogenic and angiogenic genes in the tendons of Mkx^(−/−)mice.Single-cell RNA sequencing analyses of wild-type and Mkx^(−/−)tendons identified three cell types and revealed the excessive activation of osteochondrogenic genes during the tenogenesis of Mkx^(−/−)tendon cells.Single-cell analysis revealed that the gene expression program of angiogenesis,which is strongly associated with bone formation,was activated in all cell types during HO.Moreover,inhibition of angiogenesis by the small-molecule inhibitor BIBF1120 attenuated bone formation and angiogenesis in the Achilles tendons of both Mkx mutant mice and a rat traumatic model of HO.These findings provide new insights into the cellular mechanisms of tendon HO and highlight the inhibition of angiogenesis with BIBF1120 as a potential treatment strategy for HO. | Junxin Lin Yuwei Yang Wenyan Zhou Chao Dai Xiao Chen Yuanhao Xie Shan Han Huanhuan Liu Yejun Hu Chenqi Tang Varitsara Bunpetch Dandan Zhang Yishan Chen Xiaohui Zou Di Chen Wanlu Liu Hongwei Ouyang | 2022 | Bone Research2022，10，4： | 1 |
| 18 | Molecular cloning and characterization of a surface-localized adhesion protein in Myco- plasma boris Hubei-1 strain 显示文摘 | Zou Xiaohui Li Yuan Liu Yang | 2013 | PLoS One2013，8，69： | 1 |
| 19 | An im proved HAdV41 E1B55K-expressing 293 cell line for packaging fastidious adenovirus显示文摘 | Zou Xiaohui Xiao Xia Chen Duoling | 2011 | J Virol Methods2011，175，2： | 1 |
| 20 | Mineral surface modification induced by low energy ion irradiation: Implications for solar-wind exposure effects in lunar soil显示文摘We performed ion irradiation on olivine and ilmenite to simulate solar-wind exposure effects in lunar soil. The surface morphology and microstructure after ion irradiation were characterized by field emission scanning electron microscopy. Sputtering erosion significantly modified the surface of irradiated Luobusha olivine grains. All irradiated grains show smooth surface and round shape. The cleavage fractures on the unirradiated olivine surface were widened and deeply etched after He+ irradiation. Both of these are the consequence of ion sputtering erosion. There are no bubbles or voids foundin the irradiated olivine grains, because He+ dose in this study is lower than saturated fluence. Irradiated Panzhihua ilmenite grains are all covered with smooth flakes with the thickness of about 400 nm. The formation of the flakes should be related with helium bubbles and their growth during He+ implantation. Some columnar-shaped particles are found at the surface of irradiated Panzhihua ilmenite. We speculate that these particles should be sulfide because of significantly high sulfur contents. | ZHU Yongchao FU Xiaohui XU Lin ZHANG Feng ZHENG Yongchun ZOU Yongliao | 2014 | Chinese Journal Of Geochemistry2014，33，4： | 1 |
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