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| 1 | Clinical implications and prognostic value of single and combined biomarkers in endometrial carcinoma显示文摘 | Li Mingzhu Zhao Lijun Shen Danhua Li Xiaoping Wang Jianliu Wei Lihui | 2014 | Chinese Medical Journal2014，，8： | 8 |
| 2 | Histone modifications and their regulatory roles in plant development and environmental memory显示文摘Plants grow in dynamic environments where they receive diverse environmental signals.Swift and precise control of gene expression is essential for plants to align their development and metabolism with fluctuating surroundings.Modifications on histones serve as histone code' to specify chromatin and gene activities.Different modifications execute distinct functions on the chromatin,promoting either active transcription or gene silencing.Histone writers,erasers,and readers mediate the regulation of histone modifications by catalyzing,removing,and recognizing modifications,respectively.Growing evidence indicates the important function of histone modifications in plant development and environmental responses.Histone modifications also serve as environmental memory for plants to adapt to environmental changes.Here we review recent progress on the regulation of histone modifications in plants,the impact of histone modifications on environment-controlled developmental transitions including germination and flowering,and the role of histone modifications in environmental memory. | Ting Zhao Zhenping Zhan Danhua Jiang | 2019 | Journal of Genetics and Genomics2019，46，10： | 8 |
| 3 | The INO80 chromatin remodeling complex promotes thermo-morphogenesis by connecting H2A.Z eviction and active transcription in Arabidopsis.显示文摘Global warming imposes a major threat to plant growth and crop production. In some plants including Arabidopsis thaliana, elevated temperatures induce a series of morphological and developmental adjustments, termed thermomorphogenesis to facilitate plant cooling under high-temperature conditions. Plant thermal response is suppressed by histone variant H2A.Z. At warm temperatures, H2A.Z is evicted from nucleosomes at thermo-responsive genes, resulting in their expression changes. However, the mechanisms that regulate H2A.Z eviction and subsequent transcription changes are largely unknown. Here, we show that the INO80 chromatin remodeling complex (INO80-C) promotes thermomorphogenesis and activates the expression of thermo-responsive and auxin-related genes. INO80-C associates with PHYTOCHROME-INTERACTING FACTOR 4 (PIF4), a potent regulator in thermomorphogenesis, and mediates temperature-induced H2A.Z eviction at PIF4 targets. Moreover, INO80-C directly interacts with COMPASS-like and transcription elongation factors to promote active histone modification Histone H3 lysine 4 trimethylation (H3K4me3) and RNA Polymerase II (RNA Pol II) elongation, leading to the thermal induction of transcription. Notably, transcription elongation factors SPT4 and SPT5 are required for the H2A.Z eviction at PIF4 targets, suggesting the cooperation of INO80-C and transcription elongation in H2A.Z removal. Our results demonstrate that the (PIF4)-(INO80-C)-(COMPASS-like)-(transcription elongator) module controls plant thermal response, and establish a link between H2A.Z eviction and active transcription. | Xue Mande Zhang Huairen Zhao Fengyue Zhao Ting Li Hui Jiang Danhua | 2021 | Molecular Plant2021，14，11： | 8 |
| 4 | BMPR2 and HIF1-α overexpression in resected osteosarcoma correlates with distant metastasis and patient survival显示文摘Objective: Bone morphogenetic protein receptor 2(BMPR2) and hypoxia-inducible factor 1-α(HIF1-α) existed abnormal expression in several types of cancer. However, their expressions and related roles in osteosarcoma are largely unknown.Methods:To investigate the clinical significance of BMPR2 and HIF1-αin osteosarcoma,we analyzed their expression levels in 103 osteosarcoma specimens by immunochemistry.Meanwhile,we conducted a follow-up to examine the metastatic behavior and overall survival(OS)of osteosarcoma patients.Results:Among 103 tissues,61 cases had BMPR2-positive expression and 57 cases had HIF1-αpositive expression.A significant correlation was noticed between BMPR2 and HIF1-αexpression in osteosarcoma specimens(P=0.035).Receiver-operating characteristic(ROC)curves were calculated to investigate the predictive value of the two markers in tumor metastasis.By means of univariate and multivariate analysis,BMPR2 and HIF1-αexpression,as well as higher tumor grade,were identified as significant risk factors for OS in patients with osteosarcoma.Kaplan-Meier survival analysis revealed that the patients with BMPR2 and HIF1-αpositive expression had worse OS compared with patients with BMPR2-negative or HIF1-α-negative staining.Conclusions:It can be concluded that BMPR2 and HIF1-αexpression is highly correlated with metastatic behavior in patients with osteosarcoma and can serve as predictive markers for metastasis and OS of these patients. | Shidong Wang Tingting Ren Yi Huang Xing Bao Kunkun Sun Danhua Shen Wei Guo | 2017 | Chinese Journal of Cancer Research2017，29，5： | 7 |
| 5 | Audiological evaluation in Chinese patients with mitochondrial encephalomyopathies显示文摘 | Liu Yuhe Xue Junfang Zhao Danhua Chen Li Yuan Yun Wang Zhaoxia | 2014 | Chinese Medical Journal2014，，12： | 6 |
| 6 | Characteristic analysis of wind field and sea wave field over the NW Pacific Ocean显示文摘According to ship observation data over the NW Pacific Ocean during 1950 - 1995. taking 5°×5° grid, the characteristics and variation rule of wind, wave and swell are analyzed. This area is typical monsoon area. In the period of monsoon, the directions of wind, sea wave and swell are roughly consistent. Sea wave of northeasterly is always prevailing in equatorial zone. The monsoon in winter is stronger than in summer, correspondingly, average wave height is higher, and the frequencies of high sea and heavy swell are also bigger. Both of North Indian Ocean and adjacent sea area is also monsoon area, but characteristic is opposite. This paper provides specific data of wind field and wave field and variaton for ship navigation, operation and scientific experiment in the NW Pacific Ocean. | Jinfang Liu(刘金芳) Xiaowei Tang(唐晓卫) Danhua He(何丹华) | 2001 | 海洋预报2001，18，z1： | 5 |
| 7 | Advances in COVID-19 mRNA vaccine development显示文摘To date,the coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has determined 399,600,607 cases and 5,757,562 deaths worldwide.COVID-19 is a serious threat to human health globally.The World Health Organization(WHO)has declared COVID-19 pandemic a major public health emergency.Vaccination is the most effective and economical intervention for controlling the spread of epidemics,and consequently saving lives and protecting the health of the population.Various techniques have been employed in the development of COVID-19 vaccines.Among these,the COVID-19 messenger RNA(mRNA)vaccine has been drawing increasing attention owing to its great application prospects and advantages,which include short development cycle,easy industrialization,simple production process,flexibility to respond to new variants,and the capacity to induce better immune response.This review summarizes current knowledge on the structural characteristics,antigen design strategies,delivery systems,industrialization potential,quality control,latest clinical trials and real-world data of COVID-19 mRNA vaccines as well as mRNA technology.Current challenges and future directions in the development of preventive mRNA vaccines for major infectious diseases are also discussed. | Enyue Fang Xiaohui Liu Miao Li Zelun Zhang Lifang Song Baiyu Zhu Xiaohong Wu Jingjing Liu Danhua Zhao Yuhua Li | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 5 |
| 8 | Geographical Variation and Influencing Factors of Spartina alterniflora Expansion Rate in Coastal China显示文摘Biological invasion poses a huge threat to ecological security.Spartina alterniflora was introduced into China in 1979,and its arrival corresponded with negative effects on native ecosystems.To explore geographical variation of its expansion rate in coastal China,we selected 43 S.alterniflora sites from Tianjin Coastal New Area to Beihai.The area expansion rate,expansion rate paralleling and vertical to the shoreline were analysed based on Landsat images and field survey in 2015.Simple Ocean Data Assimilation(SODA)and climate data were collected to statistically analyse the influential factors of expansion rate.Results showed that significant difference of S.alterniflora area expansion rate among different latitude zones(P<0.01),increasing from 6.08%at southern(21°N–23°N)to 19.87% in Bohai Bay(37°N–39°N)along latitude gradient.There was a significant difference in expansion rate vertical to shoreline in different latitude zones(P<0.01)with the largest occurring in Bohai Bay(256m/yr,37°N–39°N),and showed an decreasing tendency gradually from north to south.No significant difference and latitudinal clines in expansion rate paralleling to shoreline were observed.Expansion rate had significant negative correlation with mean seawater temperature,the lowest seawater temperature,current zonal velocity and meridional velocity and presented a reducing trend as these biotic factors increased;however,they were not significantly correlated with the highest seawater temperature and mean seawater salinity.We identified significant correlations between expansion rate and annual mean temperature,the lowest temperature in January and annual precipitation,but there was little correlation with annual diurnal difference in temperature and the highest temperature in July.The rapid expansion rate in high-latitude China demonstrated a higher risk of potential invasion in the north;dynamic monitoring and control management should be established as soon as possible. | ZHANG Danhua HU Yuanman LIU Miao CHANG Yu SUN Lishuang | 2020 | Chinese Geographical Science2020，30，1： | 4 |
| 9 | Lens distortion correction based on one chessboard pattern image显示文摘这份报纸建议西洋象棋盘角落的一个察觉方法改正照相机 distortionsincluding 光线的失真, decentering 失真和棱柱失真。这个建议方法能完成高角落察觉率。然后,我们使用了反复的过程优化失真参数最小化失真剩余。首先,在这个方法,非失真点被四个点在图象中心附近评估;第二, Levenberg-Marquardt 非线性的优化算法被采用计算失真参数,然后由这些参数改正图象;第三,我们在改正的图象上计算了角落点,并且重复了以前的二步直到失真参数收敛。结果证明由反复的过程的建议方法能在可以忽略的图象中心和一根线的失真剩余的一般水准附近做细微失真的影响是几乎 0.3 个象素。 | Yubin WU Shixiong JIANG Zhenkun XU Song ZHU Danhua CAO | 2015 | Frontiers of Optoelectronics2015，8，3： | 3 |
| 10 | LHP1 Interacts with ATRX through Plant-Specific Domains at Specific Loci Targeted by PRC2显示文摘(HP1 ) Heterochromatin 蛋白质 1 是染色质结构和功能的一个主要管理者。在动物,与 HP1 交往的蛋白质的网络主要与组成的 heterochromatin 由 H3K9me3 标记被联系。HP1 身体上与 SNF2 染色质 remodeler ATRX 的通常认为的 ortholog ?交往,它在哺乳动物控制 histone 变体 H3.3 的免职。在这研究,我们证明 ATRX 的 Arabidopsis thaliana ortholog ?参予 H3.3 免职并且在植物拥有特定的保存领域。我们发现象 HP1 (LHP1 ) 蛋白质一样的那植物通过在陆地植物明确地演变的领域与 ATRX 交往 ? 祖先。在 Arabidopsis 的 ATRX 功能的损失影响 PRC2 (POLYCOMB 压抑的建筑群 2 ) 控制的基因的一个有限子集的表示,包括 flowering 时间管理者 FLC。在 flowering 时间的规定的 ATRX 的函数要求新奇交往 LHP1 领域和 ATRX SNF2 helicase 域的 ATPase 活动。一起拿,这些结果建议不同进化小径在植物在哺乳动物和它的对应物 LHP1 导致了在 ATRX 和 HP1 之间的相互作用,导致 transcriptional 的不同模式规定。 | Haifeng Wang Danhua Jiang Elin Axelsson Zdravko J. Lorkovic Sean Montgomery Sarah Holec Bas J.G.E. Pieters Abbas H.K. AI Temimi Jasmin Mecinovic Frederic Berger | 2018 | Molecular Plant2018，11，8： | 3 |
| 11 | Defect detection on button surfaces with the weighted least-squares model显示文摘缺点察觉在生产线上的优秀保证是重要的。这份报纸用加权的最少平方的模型论述一个快 machine-vision-based 表面缺点察觉方法。我们假设一幅检查图象能被认为是一幅没有缺点的模板图象和一幅剩余图象的联合。没有缺点的模板图象从适应地训练样品被产生,并且剩余图象是在每幅检查图象和相应没有缺点的模板图象之间的减法的结果。在加权的最少平方的模型,边附近的剩余错误被压制减少空间错误排列引起的虚惊。钮扣的不同类型上的实验结果证明建议方法对照明颤动和旋转偏差柔韧并且生产比二个另外的方法的那些好的结果。 | Yu HAN Yubin WU Danhua CAO Peng YUN | 2017 | Frontiers of Optoelectronics2017，10，2： | 3 |
| 12 | A high quality image reconstruction method based on nonconvex decoding显示文摘The article proposes a fast reconstruction algorithm for l0≤p≤1 norm nonconvex model,called Gradient projection nonconvex sparse recovery(GPNSR),which makes a good performance in high-quality image reconstruction.We apply the GPNSR into canonical multiple description coding theory and propose a robust high-quality compressed sensing-based coding method.Combined with iterative weighted technique and fast gradient descent method,the proposed method implicitly implements matrix inverse operations to highly reduce the storage pressure.Also the weighted norm method is taken to optimize the descent steps,which highly increases convergent speed of the algorithm.Taking an image has sparse Fourier representations as an example,the paper presents the detailed image sparse coding and fast reconstruction procedure.By integrating the compressive sensing multi-description coding framework,the simulation demonstrates the superior reconstruction performance of the proposed algorithm.Most importantly,with p close to zero,the reconstruction performance of GPNSR can approximate that of l0 norm optimization result. | ZHAO GuangHui SHEN FangFang WANG ZhengYang WU WeiJia SHI GuangMing LIU DanHua | 2013 | Science China(Information Sciences)2013，56，11： | 3 |
| 13 | Traditional Chinese medicines and their active ingredients sensitize cancer cells to TRAIL-induced apoptosis显示文摘The rapidly developing resistance of cancers to chemotherapy agents and the severe cytotoxicity of such agents to normal cells are major stumbling blocks in current cancer treatments.Most current chemotherapy agents have significant cytotoxicity,which leads to devastating adverse effects and results in a substandard quality of life,including increased daily morbidity and premature mortality.The death receptor of tumor necrosis factor-related apoptosis-inducing ligand(TRAIL)can sidestep p53-dependent pathways to induce tumor cell apoptosis without damaging most normal cells.However,various cancer cells can develop resistance to TRAIL-induced apoptosis via different pathways.Therefore,it is critical to find an efficient TRAIL sensitizer to reverse the resistance of tumor cells to TRAIL,and to reinforce TRAIL’s ability to induce tumor cell apoptosis.In recent years,traditional Chinese medicines and their active ingredients have shown great potential to trigger apoptotic cell death in TRAIL-resistant cancer cell lines.This review aims to collate information about Chinese medicines that can effectively reverse the resistance of tumor cells to TRAIL and enhance TRAIL’s ability to induce apoptosis.We explore the therapeutic potential of TRAIL and provide new ideas for the development of TRAIL therapy and the generation of new anticancer drugs for human cancer treatment.This study involved an extensive review of studies obtained from literature searches of electronic databases such as Google Scholar and PubMed.'TRAIL sensitize'and'Chinese medicine'were the search keywords.We then isolated newly published studies on the mechanisms of TRAIL-induced apoptosis.The name of each plant was validated using certified databases such as The Plant List.This study indicates that TRAIL can be combined with different Chinese medicine components through intrinsic or extrinsic pathways to promote cancer cell apoptosis.It also demonstrates that the active ingredients of traditional Chinese medicines enhance the sensitivity of cancer cells to TRAIL-mediated apoptosis.This provides useful information regarding traditional Chinese medicine treatment,the development of TRAIL-based therapies,and the treatment of cancer. | Bingyu SUN Yongqiang LIU Danhua HE Jinke LI Jiawei WANG Wulin WENS Ming HONG | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，3： | 3 |
| 14 | Selective exchange of alkali metal ions on EAB zeolite显示文摘EAB zeolite was successfully prepared and applied to selective adsorption of Li^(+),Na^(+)and K^(+)ions.The physical and chemical properties of the adsorbent were characterized by X-ray diffraction(XRD),X-ray fluorescence(XRF),scanning electron microscope(SEM)and thermogravimetry(TG)methods.The ion exchange behaviours for Li^(+),Na^(+)and K^(+)ions in monomcomponent and multicomponent solutions were studied.In independent ion exchange,the ion exchange capacities ratiosα(/Na/Li)andα(K/Li)were 3.8 and 6.2,respectively.In competitive ion exchange,the selectivitiesβ(Na/Li)andβ(K/Li)increased with the initial concentrations and reached 409 and 992 when the initial concentrations was 100 mmol/L.The thermodynamic study results showed that Gibbs free energy change(ΔGΘ)of ion exchange reaction between Li-EAB and K^(+)was-34.96 kJ/mol,indicating that ion exchange of K^(+)ions was more energetically favourable than Li^(+)ions.The calculation results showed that the energy barriers of ion exchange increased in the order K^(+)Na^(+) | Yansi Tong Danhua Yuan Wenna Zhang Yingxu Wei Zhongmin Liu Yunpeng Xu | 2021 | Journal of Energy Chemistry2021，30，7： | 2 |
| 15 | Microbial community structure analyses and cultivable denitrifier isolation of Myriophyllum aquaticum constructed wetland under low C/N ratio显示文摘With the rapid expansion of livestock production,the amount of livestock wastewater accumulated rapidly.Lack of biodegradable organic matter makes denitrification of livestock wastewater after anaerobic digestion more difficult.In this study,Myriophyllum aquaticum constructed wetlands(CWs)with efficient nitrogen removal performance were established under different carbon/nitrogen(C/N)ratios.Analysis of community composition reveals the change of M.aquaticum CWs in microbial community structure with C/N ratios.The proportion of Proteobacteria which is one of the dominant phyla among denitrifier communities increased significantly under low C/N ratio conditions.Besides,to obtain cultivable denitrifier that could be added into CWs in situ,33 strains belonging to phylum Proteobacteria were isolated from efficient M.aquaticum CWs,while the best-performing denitrification strain M3-1 was identified as Bacillus velezensis JT3-1(GenBank No.CP032506.1).Redundancy analysis and quadratic models showed that C/N ratio had significant effects on disposal of nitrate(NO_(3)^(−)-N)and the strains isolated could perform well in denitrification when C/N ratio is relatively low.In addition,they have relatively wide ranges of carbon sources,temperature and a high NO_(3)^(−)removal rate of 9.12 mg/(L·hr)at elevated concentrations of 800 mg/L nitrate.Thus,strains isolated from M.aquaticum CWs with low C/N ratio have a practical application value in the treatment of nitrate-containing wastewater.These denitrifying bacteria could be added to CWs to enhance nitrogen removal efficiency of CWs for livestock wastewater with low C/N ratio in the future. | Jialiang Zuo Lina Xu Jianlin Guo Shengjun Xu Shuanglong Ma Cancan Jiang Dongmin Yang Danhua Wang Xuliang Zhuang | 2023 | Journal of Environmental Sciences2023，，5： | 2 |
| 16 | Spatial dynamics of a nonlocal delayed unstirred chemostat model with periodic input显示文摘In this paper,a nonlocal delayed chernostat model of a single species feeding on a periodically varying input nutrient is proposed.By the theory of semigroup,the existence and uniqueness of solution of the system are obtained.Furthermore,we investigate a threshold result on the global dynamics,and the uniform persistence of the system is established. | Wu-Jun Pu Danhua Jiang Ya Wang Zhanbing Bai | 2019 | International Journal of Biomathematics2019，12，6： | 2 |
| 17 | Nrf2/ARE pathway activation is involved in negatively regulating heat-induced apoptosis in non-small cell lung cancer cells显示文摘Hyperthermia,particularly in combination with chemoradiotherapy,is widely used to treat various cancers.However,hyperthermia treatment is often insufficient due to thermo-tolerance.To date,the detailed mechanism underlying thermo-tolerance has not been clarified.The nuclear factor erythroid 2-related factor 2(Nrf2)/antioxidant response element(ARE)pathway is an important cellular cytoprotective defense system that is activated by various stresses.In this study,using immunocytochemistry and western blot analysis,we demonstrated that heat stress induced Nrf2/ARE activation through the nuclear translocation of Nrf2 in non-small cell lung cancer cells.Luciferase activity was also increased.Additionally,antioxidant enzymes were increased through Nrf2 activation after heat stress.Transfection of lung cancer cells with siRNA directed against Nrf2 increased heat cytotoxicity and cell apoptosis.Heat stress could induce reactive oxygen species(ROS)accumulation,while the antioxidant NAC obviously reduced cell apoptosis ratio,indicating that heat stress induced cell apoptosis in a ROS-dependent manner.Knockdown of Nrf2 led to an abnormal elevation of ROS,and the antioxidant NAC could increase Nrf2 activation,indicating that ROS and Nrf2 act within a negative feedback loop.Taken together,these results demonstrated that Nrf2 pathway is important for maintaining resistance to heat stress,and we postulated that Nrf2 may represent a potential therapeutic target for hyperthermia in lung cancer. | Wenyue Xie Benxu Tan Zhenzhou Yang Xian Yu Lingxiu Chen Danhua Ran Qing Xu Xiangdong Zhou | 2020 | Acta Biochimica et Biophysica Sinica2020，52，4： | 2 |
| 18 | Core-satellite metal-organic framework@upconversion nanoparticle superstructures via electrostatic self-assembly for efficient photodynamic theranostics显示文摘The nanoplatforms based on upconversion nanoparticles(UCNPs)have shown great promise in amplified photodynamic therapy(PDT)triggered by near-infrared(NIR)light.However,their practical in vivo applications are hindered by the overheating effect of 980 nm excitation and low utilization of upconversion luminescence(UCL)by photosensitizers.To solve these defects,core-satellite metal-organic framework@UCNP superstructures,composed of a single metal-organic framework(MOF)NP as the core and Nd3+-sensitized UCNPs as the satellites,are designed and synthesized via a facile electrostatic self-assembly strategy.The superstructures realize a high co-loading capacity of chlorin e6(Ce6)and rose bengal(RB)benefitted from the highly porous nature of MOF NPs,showing a strong spectral overlap between maximum absorption of photosensitizers and emission of UCNPs.The in vitro and in vivo experiments demonstrate that the dual-photosensitizer superstructures have trimodal(magnetic resonance(MR)/UCL/fluorescence(FL))imaging functions and excellent antitumor effectiveness of PDT at 808 nm NIR light excitation,avoiding the laser irradiation-induced overheating issue.This study provides new insights for the development of highly efficient PDT nanodrugs toward precision theranostics. | Zhike Li Xi Qiao Guihua He Xin Sun Danhua Feng Liefeng Hu Hua Xu Hai-Bing Xu Shengqian Ma Jian Tian | 2020 | Nano Research2020，13，12： | 2 |
| 19 | Binary blazed grating-based on silicon polarization-independent filter on insulator显示文摘 | Danhua WU Xin SUI Junbo YANG Zhiping ZHOU | 2012 | Frontiers of Optoelectronics2012，5，1： | 2 |
| 20 | Plasma reforming of toluene as a model tar compound from biomass gasification:effect of CO_(2) and steam显示文摘In this study, plasma reforming of toluene as a tar model compound from biomass gasification has been carried out using an AC gliding arc discharge reactor. The influence of steam and CO_(2) addition on the reforming of toluene has been evaluated. The results show that the highest toluene conversion (59.9%) was achieved when adding 3 vol% CO_(2) at a toluene concentra-tion of 16.1 g/Nm3 and a specific energy input of 0.25 kWh/m3. Further increasing CO_(2) concentration to 12 vol% decreased the conversion of toluene. The presence of steam in the plasma CO_(2) reforming of toluene creates oxidative OH radicals which contribute to the enhanced conversion of toluene and energy efficiency of the plasma reforming process through stepwise oxidation of toluene and reaction intermediates. Hydrogen and C_(2)H_(2) were identified as the major gas products in the plasma reforming of toluene without CO_(2) or steam, with a yield of 9.7% and 14.5%, respectively, while syngas was the primary products with a maximum yield of 58.3% (27.5% for H_(2) and 30.8% for CO) in the plasma reforming with the addition of 12 vol% CO_(2). The plausible reaction pathways and mechanism in the plasma reforming of toluene have been proposed through the combination of the analysis of gas and condensed products and spectroscopic diagnostics. | Shiyun Liu Danhua Mei Yaolin Wang Yichen Ma Xin Tu | 2019 | Waste Disposal and Sustainable Energy2019，1，2： | 2 |
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