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| 1 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 2 | TALEN mediated Nanog disruption r esults in less invasiveness, more chemosensitivity and reversal of EMT in Hela cells显示文摘 | Ding Y Yu AQ Li CL | 2014 | Oncotarget2014，5，18： | 1 |
| 3 | Associations of body mass index and insulin resistance with leptin,adiponectin,and the leptintoadiponectin ratio across ethnic groups:the MultiEthnic Study of Atherosclerosis(MESA)显示文摘 | RasmussenTorvik LJ Wassel CL Ding J | 2012 | Ann Epidemiol2012，22，10： | 1 |
| 4 | The overexpression of 14-3-3ζand Hsp27 promotes non-small cell lung cancer progression显示文摘 | Zhao GY Ding JY Lu CL | 2014 | Cancer2014，120，5： | 1 |
| 5 | MiR-221accentuates IFN’s anti-HCV effect by downregulating SOCS1and SOCS3显示文摘 | Xu G Yang F Ding CL | 2014 | Virology2014，，1： | 1 |
| 6 | OVerexpression of CD88 predicts poor prognosis in non-small-cell lung cancer显示文摘 | Gu J Ding JY Lu CL et a1 | 2013 | Lung Cancer2013，81，2： | 1 |
| 7 | Physiological basis of different allelopathic reactions of cucumber and fig leaf gourd plants to cinnamic acid显示文摘 | Ding J Sun Y Xiao CL | 2007 | Journal of Experimental Botany Volume2007，58，13： | 1 |
| 8 | Valproic acid substantiallydownregulated genes folrl,IGF2R,RGS2,COL6A3,EDNRB,KLF6,and pax-3,N-acetylcysteine alleviated most of the inducedgene alterations in chicken embryo model显示文摘 | Hsieh CL Chen KC Ding CY | 2013 | Rom J Morphol Embry-ol2013，54，4： | 1 |
| 9 | 5-aza-2'-deoxycytidine leads to reduced embryo implantation and reduced expression of DNA methyltransferases and essential endometrial genes显示文摘 | Ding YB Long CL Liu XQ | 2012 | PLo S One2012，7，45： | 1 |
| 10 | Laser-treated hydrophobic paper: an inexpensive microfluidic platform 显示文摘 | Chitnis G Ding Z Chang CL | 2011 | Lab Chip2011，11，6： | 1 |
| 11 | Extracellular FGF-1 inhibits cytoskeletal organization and promotes fibroblast motility 显示文摘 | Ding Q Cladson CL Guidry CR | 2000 | Growth Factors2000，18，2： | 1 |
| 12 | Extracellular FGF-1 inhibits cytoskeletal organization and promotes fibroblast motility显示文摘 | Ding Q Gladson CL Guidry CR | 2000 | Growth Factors2000，18，2： | 1 |
| 13 | Comparisons between oral pulse alfacalcidol therapy and daily therapy in maintenance hemodialysis patients with secondary hyperparathyroidism: a randomized, controlled, and multicenter study 显示文摘 | Gu Y Ding F Chen N Mei CL Qian JQ Wang xY | 2005 | Ren Fail2005，27，2： | 1 |
| 14 | Matrix metalloproteinases in the aneurysm wall of patients treated with low-dose doxycycline 显示文摘 | Ding R McGuinness CL Burnand KG | 2005 | J Vasc2005，13，5： | 1 |
| 15 | The overexpression of 14-3-3 ζand Hsp27 promotes non small cell lung cancer progression显示文摘 | Zhao GY Ding JY Lu CL | 2014 | Cancer2014，120，5： | 1 |
| 16 | TALEN-mediated Nanog disruption results in less invasiveness,more chemosensitivity and reversal of EMT in Hela cells显示文摘 | Ding Y Yu AQ Li CL | 2014 | Oncotarget2014，5，18： | 1 |
| 17 | The toxicity study on marine low temperature lysozyme 显示文摘 | Yan CL Ding BX Lan XM etal | 2008 | Food Chem Toxicol2008，46，2： | 1 |
| 18 | Paternal imprinting of Galpha(s) in the human thyroid as the basis of TSH resistance in pseudohypoparathyroidism type Ia 显示文摘 | Germain-Lee EL Ding CL Deng Z | 2002 | Biochem Biophys Res Commun2002，296，1： | 1 |
| 19 | Generation of cytotoxic T cells against HBcAg using retrovirally transduced dendritic cells显示文摘 | Ding CL Yao K Zhang TT | 2003 | World J Gastroenterol2003，9，7： | 1 |
| 20 | MERTK Arginine-844-Cysteine in a patient with severe rodcone dystrophy: loss of mutant protein function in transfected cells显示文摘 | McHenry CL Liu Y Feng W Nair AR Feathers KL Ding X | 2004 | Invest Ophthalmol Vis Sci2004，45，5： | 1 |
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