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| 1 | Transmutation of ancient settlements and environmental changes between 6000-2000 aBP in the Chaohu Lake Basin, East China显示文摘Based on the temporal-spatial distribution features of ancient settlement sites from the middle and late Neolithic Age to the Han dynasty in the Chaohu Lake Basin of Anhui Province,East China,using the methods of GIS combined with the reconstructed paleoenvironment by the records of lake sediment since Holocene,the transmutation of ancient settlements with response to environmental changes in this area has been discussed.Studies show that the main feature of transmutation of ancient settlements from the middle and late Neolithic Age to the Han Dynasty was that the distribution of settlements in this area changed from high altitudes to low ones and kept approaching the Chaohu Lake with the passage of time.These could be the response to the climate change from warm-moist to a relatively warm-dry condition during the middle Holocene,leading to the lake level fluctuations.The large area of exposed land provided enough space for human activities.These indicate that the above changes in geomorphologic evolution and hydrology influenced by climate conditions affected the transmutation of ancient settlements greatly.The distribution pattern of settlement sites was that the number of sites in the west was more than in the east.This pattern may be related to the geomorphologic conditions such as frequent channel shifting of the Yangtze River as well as flood disasters during the Holocene optimum.Therefore,climate change was the inducement of the transmutation of ancient settlements in the Chaohu Lake Basin,which exerted great influence on the distribution,expansion and development of the ancient settlements. | WU Li WANG Xinyuan ZHOU Kunshu MO Duowen ZHU Cheng GAO Chao ZHANG Guangsheng LI Lan LIU Li HAN Weiguang | 2010 | Journal of Geographical Sciences2010，20，5： | 16 |
| 2 | A case-control study about the association between vascular endothelial growth inhibitor gene polymorphisms and breast cancer risk in female patients in Northeast China显示文摘Objective: The inhibition of the neovascularization in tumors is a potential therapeutic target of cancer. Vascular endothelial growth inhibitor(VEGI) is a member of the TNF superfamily which has the ability to suppress the formation of new vessels in tumors. In order to study the association between VEGI gene polymorphisms and breast cancer risk, a case-control study was conducted in Chinese Han women in Northeast China.Methods: Our study involved 708 female breast cancer patients and 685 healthy volunteers. Four SNPs of VEGI gene were analyzed through the polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) method. The association between VEGI gene polymorphisms and breast cancer risk was analyzed in our study. The relation between VEGI gene variants and clinical features of breast cancer including lymph node(LN) metastasis, estrogen receptor(ER), progestrogen receptor(PR), tumor protein 53(p53), human epidermal growth factor receptor 2(Her-2) and triple negative(ER-/PR-/Her-2-) status was analyzed as well.Results: We found that the CT genotype and T allele of rs6478106 were more frequent in patients than in controls. There was also a statistical difference in the distribution of C_(rs6478106)G_(rs4263839) haplotype between patients and controls. In addition, SNP rs6478106 and rs4979462 were related with the Her-2 status.Conclusions: Our results suggest that VEGI gene variants may be related to the breast cancer risk and the clinical features of breast cancer in Chinese Han women in Northeast China. | Shaoli Han Lei Liu Fengyan Xu Shuang Chen Weiguang Yuan Zhenkun Fu Dalin Li Dianjun Li | 2016 | Chinese Journal of Cancer Research2016，28，4： | 7 |
| 3 | Structural basis for specific flagellin recognition by t ~ILR protein NAIP5显示文摘充满域的核苷酸绑定和包含蛋白质(NLR ) 的充满白氨酸的重复(LRR ) 作为细胞内部的有免疫力的受体工作检测导出病原体或导出主人的信号的存在。NLR 怎么察觉到他们的 ligands 的机制留下逃犯。这里,我们与 cryo 电子显微镜学在 4.28 点决定的 NLR 蛋白质 NAIP5 和 NLRC4 在建筑群报导细菌的 flagellin 衍生物的结构吗?分辨率。结构表明 flagellin 衍生物形成包括 NAIP5 的 BIR1 和 LRR 与多重领域交往的二平行 helices。对在 flagellin 衍生物的将近完全的埋葬的 NAIP5 结果有约束力,因此稳定 NAIP5 的活跃符合构造。flagellin 的极端 C 终端方面被抛锚到 NAIP5 的一个位地抑制的有约束力的衣袋,它多半由 NAIP5 为不同细菌的 flagellins 的辨别充当一个结构的决定因素,一个观点进一步由生物化学的数据支持了。一起拿,我们的结果使位于 NLR ligand 下面的分子的机制清楚些感觉。 | Xinru Yang Fan Yang Weiguang Wang Guangzhong Lin Zehan Hu Zhifu Han Yijun Qi Liman Zhang Jiawei Wang Sen-Fang Sui Jijie Chai | 2018 | Cell Research2018，28，1： | 2 |
| 4 | Corrosion Mechanism of E-glass of Chemical Resistance Glass Fiber in Acid Environment显示文摘The corrosion of ECR glass fiber was investigated by the analysis methods of weight loss ratio under different acids and at various durations.Weight loss,leaching of cations,and surface composition of ECR glass fiber were analyzed.The corrosion mechanism of ECR glass fiber in acid environment was also discussed.The experimental results showed that the corrosion degree of ECR glass fiber in different acids obeyed the order: HNO_3>H_2SO_4>HCl.The acid effects on corrosion of ECR glass fiberis were totally different.Hydrochloric acid mainly destroyed the network structure of [AlO_4],while sulfuric acid and nitric acid mainly destroyed the structure of [SiO_4].The acid resistance of ECR glass fiber is much better than that of E glass fiber due to the generation of intermediate product silicic acid gel Si(OH)_4 during ion exchange.It can adhere to the glass surface to form a thin film and hinder the proceeding of corrosion. | 谢俊 YIN Peng SHI Weiguang HU Min 王静 ZHOU Xuedong HAN Jianjun CAO Shaowen HAN Lixiong YAO Yuan | 2016 | Journal of Wuhan University of Technology(Materials Science)2016，31，4： | 1 |
| 5 | Blood–brain barrier disruption following subarchnoid hemorrhage may be faciliated through PUMA induction of endothelial cell apoptosis from the endoplasmic reticulum显示文摘 | Junhao Yan Li Li Nikan H. Khatibi Lei Yang Ke Wang Weiguang Zhang Robert D. Martin Jingyan Han John Zhang Changman Zhou | 2011 | Experimental Neurology2011，，2： | 1 |
| 6 | Gut-on-a-chip for exploring the transport mechanism of Hg(II)显示文摘Animal models and static cultures of intestinal epithelial cells are commonly used platforms for exploring mercury ion(Hg(II))transport.However,they cannot reliably simulate the human intestinal microenvironment and monitor cellular physiology in situ;thus,the mechanism of Hg(II)transport in the human intestine is still unclear.Here,a gut-on-a-chip integrated with transepithelial electrical resistance(TEER)sensors and electrochemical sensors is proposed for dynamically simulating the formation of the physical intestinal barrier and monitoring the transport and absorption of Hg(II)in situ.The cellular microenvironment was recreated by applying fluid shear stress(0.02 dyne/cm^(2))and cyclic mechanical strain(1%,0.15 Hz).Hg(II)absorption and physical damage to cells were simultaneously monitored by electrochemical and TEER sensors when intestinal epithelial cells were exposed to different concentrations of Hg(II)mixed in culture medium.Hg(II)absorption increased by 23.59%when tensile strain increased from 1%to 5%,and the corresponding expression of Piezo1 and DMT1 on the cell surface was upregulated. | Li Wang Junlei Han Weiguang Su Anqing Li Wenxian Zhang Huimin Li Huili Hu Wei Song Chonghai Xu Jun Chen | 2023 | Microsystems & Nanoengineering2023，9，1： | 0 |
| 7 | An improved method for phasing crystal structures with low non-crystallographic symmetry using cryo-electron microscopy data显示文摘 | Jia Wang (1) (2) (3) Weiguang Wang (1) (2) Wen Song (2) (3) (4) Zhifu Han (2) (3) (4) Heqiao Zhang (2) (3) (4) Jijie Chai (2) (3) (4) Hongwei Wang (2) (3) (4) Jiawei Wang (1) (2) | 2015 | Protein & Cell2015，6，12： | 0 |
| 8 | β-decay studies approaching the N=20 island of inversion with a new shell-model Hamiltonian显示文摘β-decay properties of N=18-22,Z=10-14 nuclei are analyzed with a new shell-model Hamiltonian using the Gogny densitydependent interaction.The Gogny force which has been widely and successfully used in mean-field theory can provide reasonable two-body matrix elements for cross-shell calculations.The log f t values andβ-decay level schemes are systematically studied using the D1S-Gogny interaction and compared with the SDPF-M results and experimental data.It is shown that the new Hamiltonian provides reliable results forβ-decay along with subtle level schemes for this region.Shell-model calculations with Gogny interaction can lead to a successful description of nuclei in and around the N=20 island of inversion and supplements experiment where sufficient data are not available. | WeiGuang Jiang BaiShan Hu FuRong Xu Rui Han Hui Hua | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，8： | 0 |
| 9 | Adding Chinese herbal medicine to probiotics for irritable bowel syndrome-diarrhea:A systematic review and meta-analysis of randomized controlled trials显示文摘Objective:This study assessed whether Chinese herbal medicine(CHM)combined with probiotics/synbiotics for irritable bowel syndrome-diarrhea(IBS-D)was more effective and safer than probiotics/synbiotics alone.Methods:Ten databases were searched for randomized control trials(RCTs)of IBS-D as diagnosed by Manning or Rome criteria.Trials comparing probiotics and probiotics with CHM were included.The Cochrane risk of bias(ROB)was evaluated for each trial.RevMan 5.3 was used to conduct a meta-analysis.Results:Twenty-six RCTs were included(25 Chinese,1 English),involving 2045 participants.Metaanalysis was conducted on two outcomes:overall symptom improvement and relapse.CHM combined with live Bifidobacterium and Lactobacillus preparations reduced relapse rate(RR 0.28,95%CI 0.15e0.52,3 trials,n?205)compared with probiotics alone.The subgroup analysis showed the benefit of CHM prescriptions based on soothing liver and invigorating spleen(1.28,1.14e1.44,3,244),invigorating spleen and resolving dampness(1.20,1.03e1.41,2,128),or warming and invigorating spleen and kidney formulae(1.27,1.09e1.46,2,210)combined with triple Bifidobacterium preparations than the same probiotics alone which improved overall symptoms for IBS-D.There was unclear bias in almost domains of ROB.Most studies had a high risk of bias due to lack of blinding of investigator and participants,and selective reporting.Conclusions:This study showed that CHM combined with probiotics may reduce relapse rate by 72%,and improve overall symptoms of IBS-D(as diagnosed by Rome II and III)compared to probiotics alone.From the limited subgroup analysis,only soothing liver and invigorating spleen formulae,represented by Tongxie Yaofang,added to triple Bifidobacterium preparations may be superior to the single preparations in terms of overall symptoms.However,due to the poor methodological quality and small sample size of the trials,these findings must be interpreted with caution. | Fanlong Bu Weiguang Wang Ruilin Chen Ziyi Lin Mei Han Nicola Robinson Xuehan Liu Chunli Lu Jianping Liu | 2020 | Journal of Traditional Chinese Medical Sciences2020，7，1： | 0 |
| 10 | Improving the efficiency of organic photovoltaic cells by introducing an ultrathin modification layer with a strong dipole moment显示文摘A method to improve the efficiency of organic photovoltaic cells through inclusion of an ultrathin modification layer of Al2O3 or LiF sandwiched between poly(3,4-ethylenedioxythiophene)-polystyrene sulfonic acid(PEDOT:PSS) and indium tin oxide layers is developed.Because of the strong dipole moments of LiF and Al2O3,either can enhance the built-in electric field,which increases the probability of the carriers reaching the corresponding electrode.In addition,the low work function of PEDOT:PSS can decrease the energy barrier for carrier transmission.A 21.7% improvement in the power conversion efficiency of experimental devices was achieved,mainly because the short circuit current was enhanced by almost 30%. | FU GuangSheng KONG WeiGuang HAN LingJie YANG QiMan HOU LiXin YANG ShaoPeng | 2012 | Chinese Science Bulletin2012，57，14： | 0 |
| 11 | β-decay study of neutron-rich nucleus ^(34)Al显示文摘The'island of inversion'has been known for over a quarter century,since Warburton et al.[1]proposed that nuclei with intruder ground states would constitute a 3×3 square with Z=10-12,N=20-22 in 1990.Uncovering the underlying inversion mechanism and exploring the scope of the island have attracted significant theoretical and experimental efforts in the following years.Now it is well known that the reduction of N=20 shell gap,which is likely caused by the | Rui Han XiangQing Li WeiGuang Jiang ZhiHuan Li Hui Hua ShuangQuan Zhang CenXi Yuan DongXing Jiang YanLin Ye Jing Li ZongHao Li FuRong Xu QiBo Chen Jie Meng JianSong Wang Chuan Xu YeLei Sun ChunGuang Wang HongYi Wu ChenYang Niu ChenGuang Li Chao He Wei Jiang PengJie Li HongLiang Zang Jun Feng SiDong Chen Qiang Liu XiaoChi Chen HuShan Xu ZhengGuo Hu YanYun Yang Peng Ma JunBing Ma ShiLun Jin Zhen Bai MeiRong Huang Yuan Jie Zhou WeiHu Ma Yong Li XiaoHong Zhou YuHu Zhang GuoQing Xiao WenLong Zhan | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，4： | 0 |
| 12 | 3D Tungsten Trioxide Nanosheets as Optoelectronic Materials for On-chip Quantification of Global Antioxidant Capacity显示文摘The photoelectrochemical properties of semiconductors mainly depend on the size and shape of the corresponding nanoparticles.Herein,3D WO3 nanosheets were controllably synthesized with the aid of polyethyleneimine,which presents enhanced photocurrent responses.Based on this excellent photoelectrochemical property,a photoelectrochemical chip was prepared by lithography technology for the smart monitoring of the antioxidant capacity(AC)in red wine and exhibits a series of advantages including rapid response time,high sensitivity,and long-lasting stability.The mechanism of the present photoelectrochemical sensing was explored and shows a single electron transfer reaction.Furthermore,only 200µL of samples are required for one testing,which demonstrates that the present photoelectrochemical chip can be potentially integrated with a portable commercial device(such as a mobile phone)for further research and development of food and drug supervision. | DAI Mengjiao MA Weiguang HAN Fangjie HAN Dongfang HAN Lipeng WANG Wei ZHAO Bolin HAN Dongxue NIU Li WANG Zhenxin | 2021 | Chemical Research in Chinese Universities2021，37，3： | 0 |
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