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| 1 | Radiofrequency ablation or microwave ablation combined with transcatheter arterial chemoembolization in treatment of hepatocellular carcinoma by comparing with radiofrequency ablation alone显示文摘Objective:To compare radiofrequency ablation(RFA) or microwave ablation(MWA) and transcatheter arterial chemoembolization(TACE) with RFA or MWA monotherapy in hepatocellular carcinoma(HCC).Methods:A prospective,randomized,controlled trial was conducted on 94 patients with HCC ≤7 cm at a single tertiary referral center from June 2008 to June 2010 at the Department of Hepatobiliary Surgery,the Second Affiliated Hospital of Southeast University.The patients were randomly assigned into the TACERFA or TACE-MWA(combined treatment group) and the RFA-alone or MWA-alone groups(control group).The primary end point was overall survival.The secondary end point was recurrence-free survival,and the tertiary end point was adverse effects.Results:Until the time of censor,17 patients in the TACE-RFA or TACE-MWA group had died.The median follow-up time of the patients who were still alive for the TACE-RFA or TACE-MWA group was 47.5±11.3 months(range,29 to 62 months).The 1-,3- and 5-year overall survival for the TACE-RFA or TACE-MWA group was 93.6%,68.1% and 61.7%,respectively.Twenty-five patients in the RFA or MWA group had died.The median follow-up time of the patients who were still alive for the RFA or MWA group was 47.0±12.9 months(range,28 to 62 months).The 1-,3- and 5-year overall survival for the RFA or MWA group was 85.1%,59.6% and 44.7%,respectively.The patients in the TACE-RFA or TACE-MWA group had better overall survival than the RFA or MWA group [hazard ratio(HR),0.526;95% confidence interval(95% CI),0.334-0.823;P=0.002],and showed better recurrence-free survival than the RFA or MWA group(HR,0.582;95% CI,0.368-0.895;P=0.008).Conclusions:RFA or MWA combined with TACE in the treatment of HCC ≤7 cm was superior to RFA or MWA alone in improving survival by reducing arterial and portal blood flow due to TACE with iodized oil before RFA. | Yongxiang Yi Yufeng Zhang Qiang Wei Liang Zhao Jianbo Han Yan Song Ying Ding Guilan Lu Junmao Liu Huaiying Ding Feng Dai Xiaojun Tang | 2014 | Chinese Journal of Cancer Research2014，26，1： | 29 |
| 2 | Dust storms and loess accumulation on the Tibetan Plateau: A case study of dust event on 4 March 2003 in Lhasa显示文摘Whether the Tibetan Plateau is a significant dust source area is of great importance, because this is re-lated to the understanding of sources, accumulation and environmental effects of dusts on the Tibetan Plateau and in the Far East-Pacific Ocean regions as well as to the evolution of coupling of the Tibetan Plateau and atmosphere-ocean- continent exchange. Synoptic dynamics and remote sensing tracing of a dust storm on 3 to 5 March, 2003 in Lhasa on South Tibet demonstrate that the Tibetan Plateau possesses all factors and conditions of generating dust storms. Accom-panied with this dust storm is a strong ascending stream on the Plateau which has raised various sizes of dust particles into different levels. The lifted coarse particles were largely fallen down and accumulated as loess on the eastern Tibetan Plateau, and the fine particles were translated by the west-erly jet and subsided in the northern Pacific Ocean. The spa-tial-temporal distribution of dust-storms between years 1961 and 2000 on the Plateau shows that dust-storms mainly occur in winter and early spring with high frequency, and the path of dust storm moves gradually from south to north, which is closely coupled with the northward moving of the westerly jet from winter to spring over the Tibetan Plateau. Com-pared with other twelve dust source areas in China, the Ti-betan Plateau is one of the key dust source areas for the long-distance transport because its high occurring frequency and elevation cause fine particles easily to be lifted into the zone of the westerly jet. | FANG Xiaomin HAN Yongxiang MA Jinghui SONG Lianchun YANG Shengli ZHANG Xiaoye | 2004 | Chinese Science Bulletin2004，49，9： | 25 |
| 3 | Identification of coastal wetlands of international importance for waterbirds:a review of China Coastal Waterbird Surveys 2005–2013显示文摘Background:China's coastal wetlands belong to some of the most threatened ecosystems worldwide.The loss and degradation of these wetlands seriously threaten waterbirds that depend on wetlands.Methods:The China Coastal Waterbird Census was organized by volunteer birdwatchers in China's coastal region.Waterbirds were surveyed synchronously once every month at 14 sites,as well as irregularly at a further 18 sites,between September 2005 and December 2013.Results:A total of 75 species of waterbirds met the 1 % population level Ramsar listing criterion at least once at one site.The number of birds of the following species accounted for over 20 % of the total flyway populations at a single site:Mute Swan(Cygnus olor),Siberia Crane(Grus leucogeranus),Far Eastern Oystercatcher(Haematopus osculans),Bar-tailed Godwit(Limosa lapponica),Spotted Greenshank(Tringa guttifer),Great Knot(Calidris tenuirostris),Spoon-billed Sandpiper(Calidris pygmeus),Saunders' s Gull(Larus saundersi),Relict Gull(Larus relictus),Great Cormorant(Phalacrocorax carbo),Eurasian Spoonbill(Platalea leucorodia),Black-faced Spoonbill(Platalea minor) and Dalmatian Pelican(Pelecanus crispus).A total of 26 sites supported at least one species of which their number met the1 % criterion.Forty-two species met the 1 % criterion in the Yellow River Delta,Shandong;29 at the Cangzhou coast,Hebei and 26 species at the Lianyungang coast,Jiangsu.Conclusions:The results highlight the international importance of China's coastal wetlands for waterbirds.This study also demonstrates that participation of local birdwatchers in waterbird surveys results in data that are invaluable not only for understanding the current status of waterbirds in China's coastal regions but also for waterbird conservation and management. | Qingquan Bai Jianzhong Chen Zhihong Chen Guotai Dong Jiangtian Dong Wenxiao Dong Vivian Wing Kan Fu Yongxiang Han Gang Lu Jing Li Yang Liu Zhi Lin Derong Meng Jonathan Martinez Guanghui Ni Kai Shan Renjie Sun Suixing Tian Fengqin Wang Zhiwei Xu Yat-tung Yu Jin Yang Zhidong Yang Lin Zhang Ming Zhang Xiangwu Zeng | 2015 | Chinese Birds2015，，3： | 20 |
| 4 | Long range trans-Pacific transport and deposition of Asian dust aerosols显示文摘在他们的横渡太平洋期间,运输可能引起重要海洋的浮游植物生物资源的亚洲灰尘喷雾器的免职增加。然而,横渡太平洋灰尘运输,免职,和空间分发的知识由于在亚洲次洲,北方太平洋,和北美洲的连续、同时的观察的缺乏仍然是差的。灰尘在 2001 年 4 月 6 日期间袭击的严格的亚洲人提供了一个机会获得横渡太平洋灰尘运输和免职的更好的理解,用从卫星的观察的一个全面集合,基于地面的轻察觉并且变化,飞机,和表面观察网络。观察和模型模拟构画出灰尘运输,免职,垂直侧面,和空间分发的一般模式。下列点被遵守:(1 ) 表面灰尘集中沿着运输小径从 80 ° E 与增加的灰尘运输距离指数地减少了到 120 ° W;(2 ) 灰尘集中山峰的高度与在北方太平洋区域增加运输距离增加了;并且(3 ) 灰尘免职的空间分发主要取决于横渡太平洋运输线路。 | HAN Yongxiang FANG Xiaomin ZHAO Tianliang KANG Shichang | 2008 | Journal of Environmental Sciences2008，20，4： | 14 |
| 5 | Millennial-scale climate change since the last glaciation recorded by grain sizes of loess deposits on the northeastern Tibetan Plateau显示文摘Whether climatic changes in high latitudes of the Northern Hemisphere since the last glaciation have effects on the Tibetan Plateau monsoon, and the variation characteristics of the Plateau monsoon itself are still not solved but of great significance. The 22-m high-resolution Ioess-paleosol sequence in the Hezuo Basin on the northeastern Tibetan Plateau demonstrates that the Plateau winter monsoon experienced a millennial variation similar to high latitude Northern Hemisphere, with cold events clearly correlated with Heinrich events but less for the warm events (Dansgarrd-Oeschger events). It may indicate that the climate system at high latitudes in the Northern Hemisphere had played an important role in both the Plateau monsoon and the high-level westerlies. On 10^4 year scale, there are two distinct anomalous changes, which are not found in the records from high latitude northern hemisphere, revealed by the loess grain size in the Hezuo Basin. One is that there was a considerable grain size increase at -36 kaBP, suggesting an abrupt enhancement of the Plateau winter monsoon at that time; the other is that, during 43--36 kaBP, the grain size decreased distinctly, indicating a notable weakening of the Plateau winter monsoon around that period. Both of the two anomalies suggest that the Tibetan climate may have been controlled by some other factors, besides the high latitude climatic changes in the Northern Hemisphere. | Lü Lianqing FANG Xiaomin LU Huayu HAN Yongxiang YANG Shengli LI Jijun AN Zhisheng | 2004 | Chinese Science Bulletin2004，49，11： | 13 |
| 6 | Dust storm in Asia continent and its bio-environmental effects in the North Pacific: A case study of the strongest dust event in April, 2001 in central Asia显示文摘Testing the effects of iron fertilization in booming metabolism of microbes in North Pacific Ocean has become an important hot topic in current global climate change study. The first supportive evidence with natural iron inputs to ocean was ob-tained by Bishop and his colleagues at the PAPA re-gion in North Pacific Ocean. They found a rapid in-crease of marine phytoplankton over North Pacific Ocean after a strong dust storm in April 2001. We demonstrate that the dust deposition flux during this dust storm period decreases exponentially with in-creasing distance from the dust source regions along the dust transport pathway, through integration of synoptic dynamics, changes of TOMS-AI (aerosol index) and surface PM10 values along the dust pathway and changes of particulate organic carbon and chlorophyll in surface oceans. This strong dust storm may result in deposition of about 3.1—5.8 μg/m3 eolian iron into the PAPA region in North Pa-cific Ocean, thus causing a rapid increase of marine phytoplankton productivity observed by Bishop and his colleagues. This work supplies more direct and detailed evidence, from continental dust process, to support the iron hypothesis with natural iron inputs to the surface oceans through dust storms. | HAN Yongxiang FANG Xiaomin XI Xiaoxia SONG Lianchun YANG Shengli | 2006 | Chinese Science Bulletin2006，51，6： | 8 |
| 7 | Two types of hyperthermal events in the Mesozoic-Cenozoic:Environmental impacts, biotic effects, and driving mechanisms显示文摘A deeper understanding of hyperthermal events in the Earth’s history can provide an important scientific basis for understanding and coping with global warming in the Anthropocene. Two types of hyperthermal events are classified based on the characteristics of the carbon isotope excursion(CIE) of the five representative hyperthermal events in the Mesozoic and Cenozoic. The first type is overall characterized by negative CIEs(NCHE) and represented by the Permian-Triassic boundary event(PTB, ~252 Ma), the early Toarcian oceanic anoxic event(TOAE, ~183 Ma), and the Paleocene-Eocene Thermal Maximum event(PETM, ~56 Ma). The second type is overall characterized by positive CIEs(PCHE) and represented by the early Aptian oceanic anoxic event(OAE1 a, ~120 Ma) and the latest Cenomanian oceanic anoxic event(OAE2, ~94 Ma).Hyperthermal events of negative CIEs(NCHE), lead to dramatic changes in temperature, sedimentation, and biodiversity. These events caused frequent occurrence of terrestrial wildfires, extreme droughts, acid rain, destruction of ozone layer, metal poisoning(such as mercury), changes in terrestrial water system, and carbonate platform demise, ocean acidification, ocean anoxia in marine settings, and various degree extinction of terrestrial and marine life, especially in shallow marine. In contrast,hyperthermal events of positive CIEs(PCHE), result in rapid warming of seawater and widespread oceanic anoxia, large-scale burial of organic matter and associated black shale deposition, which exerted more significant impacts on deep-water marine life,but little impacts on shallow sea and terrestrial life. While PCHEs were triggered by volcanism associated with LIPs in deep-sea environment, the released heat and nutrient were buffered by seawater due to their eruption in the deep sea, thus exerted more significant impacts on deep-marine biota than on shallow marine and terrestrial biota. This work enriches the study of hyperthermal events in geological history, not only for the understanding of hyperthermal events themselves, large igneous provinces, marine and terrestrial environment changes, mass extinctions, but also for providing a new method to identify the types of hyperthermal events and the inference of their driving mechanism based on the characteristics of carbon isotopic excursions and geological records. | Xiumian HU Juan LI Zhong HAN Yongxiang LI | 2020 | Science China Earth Sciences2020，63，8： | 4 |
| 8 | Aerosol structure and vertical distribution in a multi-source dust region显示文摘The vertical distribution of aerosols was directly observed under various atmospheric conditions in the free troposphere using surface micro-pulse lidar(MPL4) at the Zhangye Station(39.08 N,100.27 E) in western China in the spring of 2008.The study shows that the aerosol distribution over Zhangye can be vertically classified into upper,middle and lower layers with altitudes of 4.5 to 9 km,2.5 to 4.5 km,and less than 2.5 km,respectively.The aerosol in the upper layer originated from the external sources at higher altitude regions,from far desert regions upwind of Zhangye or transported from higher atmospheric layers by free convection,and the altitude of this aerosol layer decreased with time;the aerosols in the middle and lower layers originated from both external and local sources.The aerosol extinction coefficients in the upper and lower layers decreased with altitude,whereas the coefficient in the middle layer changed only slightly,which suggests that aerosol mixing occurs in the middle layer.The distribution of aerosols with altitude has three features:a single peak that forms under stable atmospheric conditions,an exponential decrease with altitude that occurs under unstable atmospheric conditions,and slight change in the mixed layer.Due to the impact of the top of the atmospheric boundary layer,the diurnal variation in the aerosol extinction coefficient has a single peak,which is higher in the afternoon and lower in the morning. | Jie Zhang Qiang Zhang Congguo Tang Yongxiang Han | 2012 | Journal of Environmental Sciences2012，24，8： | 3 |
| 9 | Immune responses of dendritic cells combined with tumor-derived autophagosome vaccine on hepatocellular carcinoma显示文摘Background:To induce and collect tumor-derived autophagosomes(DRibbles) from tumor cells as an antitumor vaccine by inhibiting the functions of proteasomes and lysosomes.Methods:Dendritic cells(DCs) generated from peripheral blood mononuclear cell(PBMC) of hepatocellular carcinoma(HCC) patients were cocultured with DRibbles,and then surface molecules of DCs,as well as surface molecules on DCs,were determined by flow cytometry.Meanwhile,immune responses of the DCs-DRibbles were examined by mixed lymphocyte reactions.Results:DRibbles significantly induced the expression of CD80,CD83,CD86 and HLA-DR on DCs.The enzyme-linked immunosorbnent assay(ELISA) showed that IFN-γ levels after vaccination increased than before in most patients,but CD8+ proportion of PBMC increased only in nine patients.Higher levels of IFN-γ were detected in the CD8+ cells than CD4+ T cells.These results suggested that DCs-DRibbles vaccine could induce antigen-specific cellular immune response on HCC and could prime strong CD8+ T cell responses,supporting it as a tumor vaccine candidate.Conclusions:Our results demonstrate that HCC/DRibbles-pulsed DCs immunotherapy might be deployed as an effective antitumor vaccine for HCC immunotherapy in clinical trials. | Yongxiang Yi Jianbo Han Liang Zhao Chunying Wang Yuan Fang Qiang Wei Liang Hu Junmao Liu Yufeng Zhang Lili Wang | 2015 | Chinese Journal of Cancer Research2015，27，6： | 2 |
| 10 | Shifts of dust source regions over central Asia and the Tibetan Plateau: Connections with the Arctic oscillation and the westerly jet显示文摘 | Yongxiang Han Xiaomin Fang Shichang Kang Huijun Wang Fenqing Kang | 2007 | Atmospheric Environment2007，，10： | 1 |
| 11 | Characteristics of Climate Change and its Response in the Qinghai-Tibet Plateau during 1971-2010显示文摘Climate data during 1971-2010 showed that mo st areas of Qinghai-Tibet Plateau showed warm wet climate change type dominated by temperature and humidity increase.Temperature increase magnitude was the smallest in spring and the largest in winter,and the precipitation increased at the low-altitude area and decreased at high altitude.The warm wet climate change caused Qinghai-Tibet Plateau alpine grassland degradation,reduction of glacier and frozen soil,wetland reduction and other environmental problems. | ZHANG Zhichun HAN Wenling WANG Jun CAI Yongxiang LI Gang CAI Zhongzhou ZHANG Chengjia SHENG Haiyan ZHAO Chaojun | 2016 | Journal of Landscape Research2016，8，6： | 1 |
| 12 | Suppression of precipitation by dust particles originated in the Tibetan Plateau显示文摘 | Han Yongxiang Fang Xiaomin Zhao Tianliang | 2009 | Atmospheric Environment2009，，43： | 1 |
| 13 | Adoptive transfer of CD4 + CD25 + regulatory T cells for prevention and treatment of spontaneous abortion显示文摘 | Yongxiang Yin Xiaofeng Han Qin Shi Yiming Zhao Yang He | 2012 | European Journal of Obstetrics and Gynecology2012，，2： | 1 |
| 14 | Solidification structure of C 2.08 Cr 25.43 Si 1.19 Mn 0.43 Fe 70.87 powders fabricated by high pressure gas atomization显示文摘 | Yongxiang Dai Min Yang Changjiang Song Qingyou Han Qijie Zhai | 2009 | Materials Characterization2009，，1： | 1 |
| 15 | Coastal wetlands in Lianyungang,Jiangsu Province,China:probably the most important site globally for the Asian Dowitcher(Limnodromus semipalmatus)显示文摘Background:Despite an increasing number of surveys and a growing interest in birdwatching,the population and distribution of Asian Dowitcher(Limnodromus semipalmatus),a species endemic to the East Asian-Australasian and Central Asian Flyways,remains poorly understood,and published information about the species is largely outdated.In boreal spring 2019,over 22,432 Asian Dowitchers were recorded in a coastal wetland at Lianyungang,Jiangsu Prov-ince,China,constituting 97.5%of its estimated global population.Methods:In 2019 and 2020,we conducted field surveys at Lianyungang to determine the numbers of Asian Dow-itchers using the area during both southward and northward migrations.We also assessed the distribution and abun-dance of Asian Dowitchers elsewhere along the China coast by searching literature and consulting expert opinion.Results:The coastal wetlands of Lianyungang are the most important stopover site for Asian Dowitchers during both northward and southward migrations;they supported over 90%of the estimated global population during north-ward migration in two consecutive years(May 2019 and 2020).This area also supported at least 15.83%and 28.42%(or 30.74%and 53.51%using modelled estimates)of the global population during southward migration in 2019 and 2020 respectively.Coastal wetlands in the west and north of Bohai Bay also have been important stopover sites for the species since the 1990s.Although comprehensive,long-term monitoring data are lacking,available evidence sug-gests that the population of the species may have declined.Conclusions:The high concentration of Asian Dowitchers at Lianyungang during migration means the species is highly susceptible to human disturbances and natural stochastic events.The coastal wetlands of Lianyungang should be protected and potentially qualify for inclusion in China’s forthcoming nomination for World Heritage listing of Migratory Bird Sanctuaries along the Coast of Yellow Sea-Bohai Gulf of China(Phase II)in 2023.Additional research is needed to understand Asian Dowitchers’distribution and ecology,as well as why such a high proportion of their population rely on the Lianyungang coast. | Ziyou Yang Jing Li Yongxiang Han Chris J.Hassell Kar-Sin Katherine Leung David S.Melville Yat-tung Yu Lin Zhang Chi-Yeung Choi | 2021 | Avian Research2021，12，3： | 1 |
| 16 | Comparative study of flexural strength test methods on CAD/CAM Y-TZP dental ceramics显示文摘Clinically,fractures are the main cause of computer-aided design and computer-aided manufacturing(CAD/CAM)3 mol%-yttria-stabilized tetragonal zirconia polycrystal(Y-TZP)all-ceramic dental restorations failure because of repetitive occlusal loading.The goal of this work is to study the effect of test methods and specimen’s size on the flexural strength of five ceramic products.Both biaxial flexure test(BI)and uni-axial flexure tests(UNI),including three-point flexure test(3PF)and four-point flexure test(4PF),are used in this study.For all five products,the flexural strength is as follows:BI>3PF>4PF.Furthermore,specimens with smaller size(3PF-s)have higher values than the bigger ones(3PF).The difference between BI and UNI resulted from the edge flaws in ceramic specimens.The relationship between different UNI(including 3PF-s,3PF and 4PF)can be explained according to Weibull statistical fracture theory.BI is recommended to evaluate the flexural strength of CAD/CAM Y-TZP dental ceramics. | Yongxiang Xu Jianmin Han Hong Lin Linan An | 2015 | Regenerative Biomaterials2015，2，4： | 1 |
| 17 | Shifts of dust source regions over Central Asia and the Tibetan Plateau: Connections with the Arctic Oscillation and the westerly jet 显示文摘 | Han Yongxiang Fang Xiaomin Kang Shichang | 2008 | Atmospheric Environment2008，42，10： | 1 |
| 18 | Lead exposure results in hearing loss and disruption of the cochlear blood–labyrinth barrier and the protective role of iron supplement显示文摘 | Xinqin Liu Gang Zheng Yongxiang Wu Xuefeng Shen Jinfei Jing Tao Yu Han Song Jingyuan Chen Wenjing Luo | 2013 | Neurotoxicology2013，，： | 1 |
| 19 | Mutation in the NS5A Region of Chinese HCV-1b Isolates and Its Correlation with Efficacy of Interferon Alpha Therapy显示文摘Objective\ To study the correlation between mutations in the NS5A region of hepatitis C virus genotype 1b and the efficacy of interferon alpha (IFN α) therapy. Methods\ Twenty patients with chronic HCV 1b infection, including 10 responders and 10 non responders to standard IFN α therapy, were investigated. HCV 1b NS5A 2209 2248 region was amplified by RT PCR and the second round product was directly sequenced before treatment. Results\ In IFN α response group, 4 out of 10 HCV isolates (40%) had mutations of amino acid in NS5A 2209 2248 region, which were all intermediate types; while in IFN α non response group, none of HCV isolates (0/10,0%) had mutations, which were all wild types (P<0.05). There was no mutant type isolates in these two groups. All patients (4/4,100%) infected with intermediate type and 6 out of 16 patients(37.5%) infected with wild type of HCV 1b were responsive to IFN α therapy (P<0.05). Conclusion\ The sequences in NS5A 2209 2248 region of Chinese HCV 1b isolates were relatively conservative. There may be a correlation between the efficacy of IFN α therapy and the mutations of amino acid in NS5A 2209 2248 region of Chinese HCV 1b isolates. | Zhang Yongxiang(张永祥) Sun Nanxiong(孙南雄)\ Huang Zuhu(黄祖瑚) Han Yaping(韩亚萍)\ Liu Ting(刘 婷) Research Laboratory of Infectious Diseases, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, P. R. China | 2000 | Journal of Nanjing Medical University2000，14，1： | 0 |
| 20 | In situ performance and stability tests of large-area flexible polymer solar cells in the 35-km stratospheric environment显示文摘Flexible organic solar cells(FOSCs)are one of the most promising power sources for aerospace aircraft due to their atractive advantages with high power-per-weight ratio and excellent mechanical flexibility.Understanding the performance and stability of high-performance FOSCs is essential for the further development of FOSCs for aerospace applications.In this paper,after systematic investigations on the performance of the state-of-the-art high-performance solar cells under thermal cycle and intensive UV irradiation conditions,in situ performance and stability tests of the solar cells in the 35 km stratospheric environment were carried out through a high-altitude balloon uploading.The encapsulated FOSCs with an area of 0.64 cm^(2)gave the highest power density of 15.26 mW/cm^(2)and an efficiency over 11%,corresponding to a power-per-weight ratio of over 3.32 k W/kg.More importantly,the cells showed stable power output during the 3-h continuous flight at 35 km and only 10%performance decay after return to the lab,suggesting promising stability of the FOSCs in the stratospheric environment. | Zihan Xu Guoning Xu Qun Luo Yunfei Han Yu Tang Ying Miao Yongxiang Li Jian Qin Jingbo Guo Wusong Zha Chao Gong Kun Lu Jianqi Zhang Zhixiang Wei Rong Cai Yanchu Yang Zhaojie Li Chang-Qi Ma | 2023 | National Science Review2023，10，4： | 0 |
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