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| 1 | Using Hourly Measurements to Explore the Role of Secondary Inorganic Aerosol in PM_(2.5)during Haze and Fog in Hangzhou, China显示文摘This paper explores the role of the secondary inorganic aerosol(SIA) species ammonium, NH+4, nitrate, NO-3, and sulfate,SO2-4, during haze and fog events using hourly mass concentrations of PM2.5measured at a suburban site in Hangzhou,China. A total of 546 samples were collected between 1 April and 8 May 2012. The samples were analyzed and classified as clear, haze or fog depending on visibility and relative humidity(RH). The contribution of SIA species to PM2.5mass increased to ~50% during haze and fog. The mass contribution of nitrate to PM2.5increased from 11% during clear to 20%during haze episodes. Nitrate mass exceeded sulfate mass during haze, while near equal concentrations were observed during fog episodes. The role of RH on the correlation between concentrations of SIA and visibility was examined, with optimal correlation at 60%–70% RH. The total acidity during clear, haze and fog periods was 42.38, 48.38 and 45.51 nmol m-3,respectively, indicating that sulfate, nitrate and chloride were not neutralized by ammonium during any period. The nitrate to sulfate molar ratio, as a function of the ammonium to sulfate molar ratio, indicated that nitrate formation during fog started at a higher ammonium to sulfate molar ratio compared to clear and haze periods. During haze and fog, the nitrate oxidation ratio increased by a factor of 1.6–1.7, while the sulfur oxidation ratio increased by a factor of 1.2–1.5, indicating that both gaseous NO2 and SO2were involved in the reduced visibility. | Roeland Cornelis JANSEN SHI Yang CHEN Jianmin HU YunJie XU Chang HONG Shengmao LI Jiao ZHANG Min | 2014 | Advances in Atmospheric Sciences2014，31，6： | 15 |
| 2 | Review of Chinese atmospheric science research over the past 70 years: Synoptic meteorology显示文摘Synoptic meteorology is a branch of meteorology that uses synoptic weather observations and charts for the diagnosis,study,and forecasting of weather.Weather refers to the specific state of the atmosphere near the Earth’s surface during a short period of time.The spatial distribution of meteorological elements in the atmosphere can be represented by a variety of transient weather phenomena,which are caused by weather systems of different spatial and temporal scales.Weather is closely related to people’s life,and its development and evolution have always been the focus of atmospheric scientific research and operation.The development of synoptic meteorology is closely related to the development of observation systems,dynamical theories and numerical models.In China,observation networks have been built since the early 1950 s.Up to now,a comprehensive meteorological observation systembased on ground,air and space has been established.In particular,the development of a new generation of dense radar networks,the development of the Fengyun satellite series and the implementation of a series of large field experiments have brought our understanding of weather from large-scale environment to thermal dynamics,cloud microphysical structure and evolution characteristics of meso and micro-scale weather systems.The development of observation has also promoted the development of theory,numerical model and simulation.In the early days,China mainly used foreign numerical models.Lately,China has developed numerical model systems with independent intellectual property rights.Based on the results of high-resolution numerical simulations,in-depth understanding of the initiation and evolution mechanism and predictability of weather at different scales has been obtained.Synoptic meteorology has gradually changed from an initially independent development to a multidisciplinary approach,and the interaction between weather and the change of climate and environment has become a hot and frontier topic in atmospheric science.This paper reviews the important scientific and technological achievements made in China over the past 70 years in the fields of synoptic meteorology based on the literatures in China and abroad,from six aspects respectively including atmospheric dynamics,synoptic-scale weather,typhoon and tropical weather,severe convective weather,numerical weather prediction and data assimilation,weather and climate,atmospheric physics and atmospheric environment. | Zhiyong MENG Fuqing ZHANG Dehai LUO Zhemin TAN Juan FANG Jianhua SUN Xueshun SHEN Yunji ZHANG Shuguang WANG Wei HAN Kun ZHAO Lei ZHU Yongyun HU Huiwen XUE Yaping MA Lijuan ZHANG Ji NIE Ruilin ZHOU Sa LI Hongjun LIU Yuning ZHU | 2019 | Science China Earth Sciences2019，62，12： | 7 |
| 3 | Engineering an enthesis-like graft for rotator cuff repair:An approach to fabricate highly biomimetic scaffold capable of zone-specifically releasing stem cell differentiation inducers显示文摘Rotator cuff(RC)attaches to humerus across a triphasic yet continuous tissue zones(bone-fibrocartilage-tendon),termed“enthesis”.Regrettably,rapid and functional enthesis regeneration is challenging after RC tear.The existing grafts bioengineered for RC repair are insufficient,as they were engineered by a scaffold that did not mimic normal enthesis in morphology,composition,and tensile property,meanwhile cannot simultaneously stimulate the formation of bone-fibrocartilage-tendon tissues.Herein,an optimized decellularization approach based on a vacuum aspiration device(VAD)was developed to fabricate a book-shaped decellularized enthesis matrix(O-BDEM).Then,three recombinant growth factors(CBP-GFs)capable of binding collagen were synthesized by fusing a collagen-binding peptide(CBP)into the N-terminal of BMP-2,TGF-β3,or GDF-7,and zone-specifically tethered to the collagen of O-BDEM to fabricate a novel scaffold(CBP-GFs/O-BDEM)satisfying the above-mentioned requirements.After ensuring the low immunogenicity of CBP-GFs/O-BDEM by a novel single-cell mass cytometry in a mouse model,we interleaved urine-derived stem cell-sheets into this CBP-GFs/O-BDEM to bioengineer an enthesis-like graft.Its high-performance on regenerating enthesis was determined in a canine model.These findings indicate this CBP-GFs/O-BDEM may be an excellent scaffold for constructing enthesis-like graft to patch large/massive RC tears,and provide breakthroughs in fabricating graded interfacial tissue. | Can Chen Qiang Shi Muzhi Li Yang Chen Tao Zhang Yan Xu Yunjie Liao Shulin Ding Zhanwen Wang Xing Li Chunfeng Zhao Lunquan Sun Jianzhong Hu Hongbin Lu | 2022 | Bioactive Materials2022，7，10： | 4 |
| 4 | Individual particle analysis of aerosols collected at Lhasa City in the Tibetan Plateau显示文摘To understand the composition and major sources of aerosol particles in Lhasa City on the Tibetan Plateau(TP), individual particles were collected from 2 February to 8 March, 2013 in Tibet University. The mean concentrations of both PM2.5and PM10 during the sampling were25.7 ± 21.7 and 57.2 ± 46.7 μg/m3, respectively, much lower than those of other cities in East and South Asia, but higher than those in the remote region in TP like Nam Co, indicating minor urban pollution. Combining the observations with the meteorological parameters and back trajectory analysis, it was concluded that local sources controlled the pollution during the sampling. Transmission electron microscopy(TEM) combined with energydispersive X-ray spectra(EDS) was used to study 408 particles sampled on four days. Based on the EDS analysis, a total of 8 different particle categories were classified for all 408 particles, including Si-rich, Ca-rich, soot, K-rich, Fe-rich, Pb-rich, Al-rich and other particles.The dominant elements were Si, Al and Ca, which were mainly attributed to mineral dust in the earth's crust such as feldspar and clay. Fe-, Pb-, K-, Al-rich particles and soot mainly originated from anthropogenic sources like firework combustion and biomass burning during the sampling. During the sampling, the pollution mainly came from mineral dust,while the celebration ceremony and religious ritual produced a large quantity of anthropogenic metal-bearing particles on 9 and 25 February 2013. Cement particles also had a minor influence. The data obtained in this study can be useful for developing pollution control strategies. | Bu Duo Yunchen Zhang Lingdong Kong Hongbo Fu Yunjie Hu Jianmin Chen Lin Li A.Qiong | 2015 | Journal of Environmental Sciences2015，27，3： | 4 |
| 5 | Effects of Jiazhu decoction in combination with cyclophosphamide on breast cancer in mice显示文摘OBJECTIVE: To investigate the therapeutic effects of Jiazhu decoction (JZD) in combination with cyclophosphamide (CTX) on the growth of breast cancer in mice and to explore the possible molecular mechanisms of action. METHODS: BALB/c mice were randomly divided into four groups of 10 (untreated model group, JZD group, CTX group, and JZD + CTX group) and subcutaneously injected with 4T1 mouse breast cancer cells. Tumors were allowed to establish for ~7 d before initiation of treatment with CTX (100 mg/kg every week by intraperitoneal injection) and/or JZD (0.015 mL of 1.65 g/mL crude drug, administered daily by gavage). The model group received equivalent volumes of vehicle on the same schedules. Tumor volumes were measured every 3 d. Mice were sacrificed after 3 weeks of treatment, and tumors were excised and subjected to RT-qPCR and western blot analysis to evaluate expression of the Wnt/β-catenin signaling pathway components β-catenin, c-Myc, and cyclin D1 at the mRNA and protein levels. RESULTS: The mean tumor volume was smaller and the growth rate was slower in the CTX and JZD + CTX groups compared with the model group (P < 0.05), and in the JZD + CTX group compared with the CTX and JZD groups (P < 0.05). Tumor growth was inhibited by 35.4% and 48.1% by CTX and JZD + CTX treatment, respectively (P < 0.001). The expression of β-catenin, c-Myc, and cyclin D1 mRNA and protein in tumors was significantly lower in mice treated with JZD or JZD + CTX compared with the untreated mice (P < 0.05), and was significantly lower in mice treated with JZD + CTX compared with either JZD or CTX alone (P < 0.05). CONCLUSION: JZD inhibited the growth of mouse breast cancer cells in vivo, possibly by reducing the expression of β-catenin, c-Myc, and cyclin D1. Combination therapy with JZD plus CTX had a more potent inhibitory effect on breast cancer growth compared with either agent alone. | Guan Huiting Xie Su Liu Shangyi Xie Qing Hou Shengkai Liu Huarong Zhang Yunjie Hu Yaqing Zhang Chenyu | 2019 | Journal of Traditional Chinese Medicine2019，39，5： | 4 |
| 6 | 2D-ultrathin MXene/DOXjade platform for iron chelation chemo-photothermal therapy显示文摘An increased demand for iron is a hallmark of cancer cells and is thought necessary to promote high cell proliferation,tumor progression and metastasis.This makes iron metabolism an attractive therapeutic target.Unfortunately,current iron-based therapeutic strategies often lack effectiveness and can elicit off-target toxicities.We report here a dual-therapeutic prodrug,DOXjade,that allows for iron chelation chemo-photothermal cancer therapy.This prodrug takes advantage of the clinically approved iron chelator deferasirox(ExJade®)and the topoisomerase 2 inhibitor,doxorubicin(DOX).Loading DOXjade onto ultrathin 2D Ti_(3)C_(2) MXene nanosheets produces a construct,Ti_(3)C_(2)-PVP@DOXjade,that allows the iron chelation and chemotherapeutic functions of DOXjade to be photo-activated at the tumor sites,while potentiating a robust photothermal effect with photothermal conversion efficiencies of up to 40%.Antitumor mechanistic investigations reveal that upon activation,Ti_(3)C_(2)-PVP@DOXjade serves to promote apoptotic cell death and downregulate the iron depletion-induced iron transferrin receptor(TfR).A tumor pH-responsive iron chelation/photothermal/chemotherapy antitumor effect was achieved both in vitro and in vivo.The results of this study highlight what may constitute a promising iron chelation-based phototherapeutic approach to cancer therapy. | Yunjie Xu Yingwei Wang Jusung An Adam C.Sedgwick Mingle Li Jianlei Xie Weibin Hu Jianlong Kang Sajal Sen Axel Steinbrueck Bin Zhang Lijun Qiao Swelm Wageh Jonathan F.Arambula Liping Liu Han Zhang Jonathan L.Sessler Jong Seung Kim | 2022 | Bioactive Materials2022，7，8： | 2 |
| 7 | ESMD-Flow: An Intelligent Flow Forwarding Scheme with Endogenous Security Based on Mimic Defense in Space-Air-Ground Integrated Network显示文摘The Space-Air-Ground Integrated Network(SAGIN) realizes the integration of space, air,and ground networks, obtaining the global communication coverage.Software-Defined Networking(SDN) architecture in SAGIN has become a promising solution to guarantee the Quality of Service(QoS).However, the current routing algorithms mainly focus on the QoS of the service, rarely considering the security requirement of flow. To realize the secure transmission of flows in SAGIN, we propose an intelligent flow forwarding scheme with endogenous security based on Mimic Defense(ESMD-Flow). In this scheme, SDN controller will evaluate the reliability of nodes and links, isolate malicious nodes based on the reliability evaluation value, and adapt multipath routing strategy to ensure that flows are always forwarded along the most reliable multiple paths. In addition, in order to meet the security requirement of flows, we introduce the programming data plane to design a multiprotocol forwarding strategy for realizing the multiprotocol dynamic forwarding of flows. ESMD-Flow can reduce the network attack surface and improve the secure transmission capability of flows by implementing multipath routing and multi-protocol hybrid forwarding mechanism. The extensive simulations demonstrate that ESMD-Flow can significantly improve the average path reliability for routing and increase the difficulty of network eavesdropping while improving the network throughput and reducing the average packet delay. | Ziyong Li Yuxiang Hu Di Zhu JiangxingWu Yunjie Gu | 2022 | China Communications2022，19，1： | 1 |
| 8 | Virtual network embedding through node connectivity显示文摘Virtual network embedding(VNE) is an essential part of network virtualization, which is considered as one of the most promising way for the future network. Its main object is to efficiently assign the nodes and links of a virtual network(VN) to a shared substrate network(SN). The NP-hard and exiting studies have put forward several heuristic algorithms. However, most of the algorithms only consider the local resource of nodes, such as CPU and bandwidth(BW), to decide the embedding, and ignore the significant impact of network attributes. Based on the attributes of entire network, a model of the connectivity between each pair of nodes was formulated to measure the resource ranking of the nodes, and a new two-stage embedding algorithm was proposed. Thereafter, the node mapping and link mapping can be jointly considered. Extensive simulation shows that the proposed algorithm improves the performance of VNE by increasing the revenue/cost ratio and acceptance ratio of VN requests while reducing the runtime. | Ding Jian Huang Tao Wang Jian Hu Wenbo Liu Jiang Liu Yunjie | 2015 | The Journal of China Universities of Posts and Telecommunications2015，22，1： | 1 |
| 9 | Auxiliary stream for optimizing memory access of video decoders显示文摘Due to the ever increasing resolution and frame rate of mainstream video sequences,memory access has become the main performance bottleneck of video decoding.To reduce the required of-chip memory,many decoders employ on-chip cache.However,they cannot distinguish whether a data block is reusable due to the lack of the information of undecoded Macro Blocks(MBs),thus often evicting reusable data from the cache and preserving non-reusable data in the cache,which will lead to a waste of of-chip memory bandwidth.In this paper,we manage to make full use of cache from a novel perspective,i.e.,auxiliary bitstream.Concretely speaking,since the memory access behavior of video decoding is determined in video encoding,the encoder can pack the memory access behaviors of video decoding as auxiliary bitstream,which can inform the decoder whether a data block will be reused by future MBs.Hence,such an auxiliary stream can enable optimal management of cache.To efectively reduce the size of auxiliary bitstream,we propose an Auxiliary Prior Information Coding(APIC)method complying with the current video standards.For future video standards,we introduce a Super Block scan Order(SBO)for MB organization to further reduce the bitrate overhead of auxiliary bitstream.The above ideas are evaluated on a number of representative video sequences.The additional prior information can reduce the required of-chip memory bandwidth for motion compensation by over 35%(for a 60 kB cache),while only causing less than 2.3%bitrate increase for high definition(HD)videos. | LIU ShaoLi LI Ling CHEN YunJi HU WeiWu | 2014 | Science China(Information Sciences)2014，57，1： | 1 |
| 10 | Fabrication of single-crystalline silicon nanowires by scratching a silicon surface with catalytic metal particles显示文摘 | Peng Kuiqing Hu Juejun Yan Yunjie | 2006 | Adv Funet Mater2006，16，： | 1 |
| 11 | Fabrication of Single-Crystalline Silicon Nanowires by Scratching a Silicon Surface with Catalytic Metal Particles显示文摘 | KUIQING JUEJUN HU YUNJIE YAN | 2006 | Advanced Functional Materials2006，，16： | 1 |
| 12 | Reliability Evaluation of Wind Power Converter Under Fault-tolerant Control Scheme with Quantification of Temperature and Humidity Effects显示文摘Wind power converter(WPC)is a key part of a wind power unit which delivers electric energy to power grid.Because of a large number of semiconductors,WPC has a high failure rate.This paper proposes a method to accurately evaluate the reliability of WPC,which is crucial for the design and maintenance of wind turbines.Firstly,the index of effective temperature(ET)is presented to quantify the effects of temperature and humidity on the semiconductor operation.A novel method is proposed to evaluate the lifetime and calculate the aging failure rates of the semiconductors considering the fluctuations of ET.Secondly,the failure mode and effect analysis(FMEA)of WPC is investigated based on the topology and control scheme.The conventional two-state reliability model of the WPC is extended to the multi-state reliability model where the partial working state under the fault-tolerant control scheme is allowed.Finally,a reliability evaluation framework is established to calculate the parameters of the WPC reliability model considering the variable failure rates and repair activities of semiconductors.Case studies are designed to verfify the proposed method using a practical wind turbine. | Xueying Yu Bo Hu Kaigui Xie Changzheng Shao Yunjie Bai Wenyuan Li Jinfeng Ding | 2023 | Journal of Modern Power Systems and Clean Energy2023，11，5： | 0 |
| 13 | Closer:Scalable Load Balancing Mechanism for Cloud Datacenters显示文摘Cloud providers(e.g.,Google,Alibaba,Amazon)own large-scale datacenter networks that comprise thousands of switches and links.A loadbalancing mechanism is supposed to effectively utilize the bisection bandwidth.Both Equal-Cost Multi-Path(ECMP),the canonical solution in practice,and alternatives come with performance limitations or significant deployment challenges.In this work,we propose Closer,a scalable load balancing mechanism for cloud datacenters.Closer complies with the evaluation of technology including the deployment of Clos-based topologies,overlays for network virtualization,and virtual machine(VM)clusters.We decouple the system into centralized route calculation and distributed route decision to guarantee its flexibility and stability in large-scale networks.Leveraging In-band Network Telemetry(INT)to obtain precise link state information,a simple but efficient algorithm implements a weighted ECMP at the edge of fabric,which enables Closer to proactively map the flows to the appropriate path and avoid the excessive congestion of a single link.Closer achieves 2 to 7 times better flow completion time(FCT)at 70%network load than existing schemes that work with same hardware environment. | Zixi Cui Pengshuai Cui Yuxiang Hu Julong Lan Fang Dong Yunjie Gu Saifeng Hou | 2021 | China Communications2021，18，4： | 0 |
| 14 | N-acetyldopamine dimer inhibits neuroinflammation through the TLR4/NF-κB and NLRP3/Caspase-1 pathways显示文摘Neuroinflammation mediated by microglia is an important pathophysiological mechanism in neurodegenerative diseases.However,there is a lack of effective drugs to treat neuroinflammation.N-acetyldopamine dimer(NADD)is a natural compound from the traditional Chinese medicine Isaria cicada.In our previous study,we found that NADD can attenuate DSS-induced ulcerative colitis by suppressing the NF-κB and MAPK pathways.Does NADD inhibit neuroinflammation,and what is the target of NADD?To answer this question,lipopolysaccharide(LPS)-stimulated BV-2 microglia was used as a cell model to investigate the effect of NADD on neuroinflammation.Nitric oxide(NO)detection,reactive oxygen species(ROS)detection and enzyme-linked immunosorbent assay(ELISA)results show that NADD attenuates inflammatory signals and proinflammatory cytokines in LPS-stimulated BV-2 microglia,including NO,ROS,tumor necrosis factor(TNF)-α,interleukin(IL)-1βand interleukin-6(IL-6).Western blot analysis show that NADD inhibits the protein levels of Toll-like receptor 4(TLR4),nuclear factor kappa-B(NF-κB),NOD-like receptor thermal protein domain associated protein 3(NLRP3),ASC and cysteinyl aspartate specific proteinase(Caspase)-1,indicating that NADD may inhibit neuroinflammation through the TLR4/NF-κB and NLRP3/Caspase-1 signaling pathways.In addition,surface plasmon resonance assays and molecular docking demonstrate that NADD binds with TLR4 directly.Our study reveals a new role of NADD in inhibiting the TLR4/NF-κB and NLRP3/Caspase-1 pathways,and shows that TLR4-MD2 is the direct target of NADD,which may provide a potential therapeutic candidate for the treatment of neuroinflammation. | Lijun Huang Leiqiang Gong Xueyan Huo Lirong Lei Qi Zhang Yunjie Hu Qixuan Kuang Yu Gui Yifei Dai Yucheng Gu Yun Deng Dong Wang Dale Guo | 2023 | Acta Biochimica et Biophysica Sinica2023，55，1： | 0 |
| 15 | Copper-catalyzed chemoselective heterocyclization of two isocyanides:Facile access to pyrroloazepinone derivatives显示文摘A Cu-catalyzed chemoselective heterocyclization of o-cinnamoyl arylisocyanides with α-substituted tosylmethyl isocyanides is developed for the efficient synthesis benzopyrroloazepinones. An isocyanide insertion into the C–Cu bond of organocuprate intermediate is involved for the formation of the sevenmembered azepinone ring. | Xiaoyu Guo Jinhuan Dong Yunjie Zhu Lan Bao Zhongyan Hu Xianxiu Xu | 2023 | Chinese Chemical Letters2023，34，2： | 0 |
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