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| 1 | Characteristics of the lunar samples returned by the Chang'E-5 mission显示文摘Forty-five years after the Apollo and Luna missions returned lunar samples,China's Chang’E-5(CE-5)mission collected new samples from the mid-latitude region in the northeastern Oceanus Procellarum of the Moon.Our study shows that 95%of CE-5 lunar soil sizes are found to be within the range of 1.40-9.35μm,while 95%of the soils by mass are within the size range of 4.84-432.27μm.The bulk density,true density and specific surface area of CE-5 soils are 1.2387 g/cm^(3),3.1952 g/cm^(3) and 0.56 m^(2)/g,respectively.Fragments from the CE-5 regolith are classified into igneous clasts(mostly basalt),agglutinate and glass.A few breccias were also found.The minerals and compositions of CE-5 soils are consistent with mare basalts and can be classified as low-Ti/low-Al/low-K type with lower rare-earth-element contents than materials rich in potassium,rare earth element and phosphorus.CE-5 soils have high FeO and low Mg index,which could represent a new class of basalt. | Chunlai Li Hao Hu Meng-Fei Yang Zhao-Yu Pei Qin Zhou Xin Ren Bin Liu Dawei Liu Xingguo Zeng Guangliang Zhang Hongbo Zhang Jianjun Liu Qiong Wang Xiangjin Deng Caijin Xiao Yonggang Yao Dingshuai Xue Wei Zuo Yan Su Weibin Wen Ziyuan Ouyang | 2022 | National Science Review2022，9，2： | 12 |
| 2 | Spatial distribution of heavy metals(Cu, Pb, Zn, and Cd)in sediments of a coastal wetlands in eastern Fujian, China显示文摘We investigated the spatial distribution(horizontal and vertical concentrations) of copper(Cu),lead(Pb), zinc(Zn), and cadmium(Cd) in five wetland types(mudflat, aquaculture wetland, water area, farmland wetland and mangrove) from three areas(Ningde, Fuding,and Xiapu), China. Cu concentrations in five wetland types descended in the order: farm wetland, mudflat, aquaculture,water area and mangrove. Pb concentrations decreased in the order: aquaculture, mangrove, farm wetland, mudflat,and water area. Zn content decreased in the order: farm wetland, water area, aquaculture, mudflat and mangrove,and Cd content decreased as follows: mangrove, aquaculture, water area, mudflat, and farm wetland. Comparison of the concentrations of the same heavy metals in different areas showed that the highest Cu(63.75 mg kg^-1) and Zn(152.32 mg kg^-1) concentrations occurred in Ningde coastal wetlands; Pb(110.58 mg kg^-1) and Cd(2.81 mg kg^-1) contents were highest in Fuding wetlands,and the average contents of all heavy metals were very low in Xiapu wetlands. Examination of the vertical distribution showed that the Cu content was high in all mudflat layers;Pb and Cd concentrations were highest in aquaculture and mangrove wetlands, respectively, and Zn content was highest in farm wetlands. The spatial distribution of Cu and Zn contents for different areas decreased as follows:Ningde [ Fuding [ Xiapu, for Pb and Cd were most concentrated in Fuding coastal wetlands. Concentrations of Zn and Cu were highly correlated, while Zn and Cu were not significantly correlated with Pb. | Lili Zhao Weibin You Haiqing Hu Wei Hong Xiaojuan LIAO Shihong Xiao Ren Wang Jinbiao Cai Xuncheng Fan Yong Tan Dongjin He | 2015 | Journal of Forestry Research2015，26，3： | 8 |
| 3 | Rhizosphere and bulk soil enzyme activities in a Nothotsuga longibracteata forest in the Tianbaoyan National Nature Reserve,Fujian Province,China显示文摘The rhizosphere, distinct from bulk soil, is defined as the volume of soil around living roots and influenced by root activities. We investigated protease,invertase, cellulase, urease, and acid phosphatase activities in rhizosphere and bulk soils of six Nothotsuga longibracteata forest communities within Tianbaoyan National Nature Reserve, including N. longibracteata + either Phyllostachys pubescens, Schima superba, Rhododendron simiarum, Cunninghamia lanceolata, or Cyclobalanopsis glauca, and N. longibracteata pure forest. Rhizosphere soils possessed higher protease, invertase, cellulase, urease,and acid phosphatase activities than bulk soils. The highest invertase, urease, and acid phosphatase activities were observed in rhizosphere samples of N. longibracteata+ S.superba. Protease was highest in the N. longibracteata + R. simiarum rhizosphere, while cellulase was highest in the pure N. longibracteata forest rhizosphere.All samples exhibited obvious rhizosphere effects on enzyme activities with a significant linear correlation between acid phosphatase and cellulase activities(p \ 0.05) in rhizosphere soils and between protease and acid phosphatase activities(p \ 0.05) in bulk soils. A principal component analysis, correlating 13 soil chemical properties indices relevant to enzyme activities, showed that protease, invertase, acid phosphatase, total N, and cellulase were the most important variables impacting rhizosphere soil quality. | Shihong Xiao Huiming You Weibin You Jinshan Liu Changtang Cai Jianqin Wu Zhirong Ji Shihua Zhan Zhesen Hu Zhongrui Zhang Dongjin He | 2017 | Journal of Forestry Research2017，28，3： | 7 |
| 4 | Phylotranscriptomics in Cucurbitaceae Reveal Multiple Whole-Genome Duplications and Key Morphological and Molecular Innovations显示文摘The ability of climbing plants to grow upward along others to reach the canopy for photosynthesis is hypothesized as a key innovation in flowering plants.Most members of the Cucurbitaceae,a family containing^1000 species and many important crops,are climbers and have characteristic tendrils and pepo fruits.Here,we present 127 newly sequenced transcdptomes and genomes along with other datasets for a total of 136 cucurbits representing all tribes to establish a robust Cucurbitaceae phylogeny containing eight highly resolved major clades.We analyzed whole-genome duplication,diversification dynamics,and ancestral morphologies,and found that after early genome duplication event(s),a burst of diversification and morphological innovations in flower,fruit,and root characters occurred under the climate optimum in the Early Eocene.Species radiation during the Mid-Eocene Climatic Optimum also coincided with several morphological changes shared by 80%of cucurbits.We found that the cucurbit-specific tendril identity gene TEN originated from a paleo-polyploidization event at the origin of the family.Our results support the hypothesis that cucurbit diversifications were probably driven by increased genetic diversity following polyploidizations and by trait morphological innovations under paleo-climate upheavals.Our study provides a phylogenetic framework and new insights into morphological and genomic changes underlying the adaptive evolution of Cucurbitaceae. | Jing Guo Weibin Xu Yi Hu Jie Huang Yiyong Zhao Lin Zhang Chien-Hsun Huang Hong Ma | 2020 | Molecular Plant2020，13，8： | 7 |
| 5 | Maize WI5 encodes an endo-1,4-β-xylanase required for secondary cell wall synthesis and water transport in xylem显示文摘Water transport from roots to leaves through xylem is important for plant growth and development.Defects in water transport can cause drought stress,even when there is adequate water in the soil.Here,we identi-fied the maize(Zea mays)wilty5(wi5)mutant,which ex-hibits marked dwarfing and leaf wilting throughout most of its life cycle under normal growth conditions.wilty5 seed-lings exhibited lower xylem conductivity and wilted more rapidly under drought,NaCl,and high temperature treat-ments than wild-type plants.Map-based cloning revealed that WI5 encodes an active endo-1,4-β-xylanase from gly-cosyl dehydration family 10,which mainly functions in degrading and reorganizing cell wall xylan.Reverse-transcription polymerase chain reaction andβ-glucuronidase assays revealed that WI5 is highly expressed in stems,especially in internodes undergoing secondary wall as-sembly.RNA sequencing suggested that WI5 plays a unique role in internode growth.Immunohistochemistry and electron microscopy confirmed that wi5 is defective in xylan deposition and secondary cell wall thickening.Lignin deposition and xylan content were markedly re-duced in wi5 compared to the wild-type plants.Our results suggest that WI5 functions in xylem cell wall thickening through its xylanase activity and thereby regulates xylem water transport,the drought stress response,and plant growth in maize. | Xiaojiao Hu Yang Cui Xiaomin Lu Weibin Song Lei Lei Jinjie Zhu Jinsheng Lai Lizhu E Haiming Zhao | 2020 | Journal of Integrative Plant Biology2020，62，10： | 3 |
| 6 | First results on ^(76)Ge neutrinoless double beta decay from CDEX-1 experiment显示文摘We report the first results on ^(76)Ge neutrinoless double beta decay from stage one of the China dark-matter experiment(CDEX).A p-type point-contact high-purity germanium detector with a mass of 994 g has been installed to detect neutrinoless double beta decay events, as well as to directly detect dark matter particles. An exposure of 304 kg d has been analyzed over a wide spectral band from 500 keV to 3 MeV. The average event rate obtained was about 0.012 counts per keV per kg per day over the 2.039 MeV energy range. The half-life of ^(76)Ge neutrinoless double beta decay derived based on this result is T^(0ν)1/2>6.4×10^(22) yr(90% C.L.). An upper limit on the effective Majorana-neutrino mass of 5.0 eV has been achieved. | Li Wang Qian Yue KeJun Kang JianPing Cheng YuanJing Li TszKing Henry Wong ShinTed Lin JianPing Chang JingHan Chen QingHao Chen YunHua Chen Zhi Deng Qiang Du Hui Gong Li He QingJu He JinWei Hu HanXiong Huang TengRui Huang LiPing Jia Hao Jiang HauBin Li Hong Li JianMin Li Jin Li Jun Li Xia Li XueQian Li YuLan Li FongKay Lin ShuKui Liu Hao Ma JingLu Ma XingYu Pan Jie Ren XiChao Ruan ManBin Shen Vivek Sharma Lakhwinder Singh Manoj Kumar Singh Manoj Kumar Singh Arun Kumar Soma ChangJian Tang WeiYou Tang ChaoHsiung Tseng JiMin Wang Qing Wang ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue LiTao Yang SongWei Yang Nan Yi ChunXu Yu HaiJun Yu WeiHe Zeng XiongHui Zeng Zhi Zeng Lan Zhang YunHua Zhang MingGang Zhao Wei Zhao JiFang Zhou ZuYing Zhou JingJun Zhu WeiBin Zhu ZhongHua Zhu | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，7： | 3 |
| 7 | 2D-ultrathin MXene/DOXjade platform for iron chelation chemo-photothermal therapy显示文摘An increased demand for iron is a hallmark of cancer cells and is thought necessary to promote high cell proliferation,tumor progression and metastasis.This makes iron metabolism an attractive therapeutic target.Unfortunately,current iron-based therapeutic strategies often lack effectiveness and can elicit off-target toxicities.We report here a dual-therapeutic prodrug,DOXjade,that allows for iron chelation chemo-photothermal cancer therapy.This prodrug takes advantage of the clinically approved iron chelator deferasirox(ExJade®)and the topoisomerase 2 inhibitor,doxorubicin(DOX).Loading DOXjade onto ultrathin 2D Ti_(3)C_(2) MXene nanosheets produces a construct,Ti_(3)C_(2)-PVP@DOXjade,that allows the iron chelation and chemotherapeutic functions of DOXjade to be photo-activated at the tumor sites,while potentiating a robust photothermal effect with photothermal conversion efficiencies of up to 40%.Antitumor mechanistic investigations reveal that upon activation,Ti_(3)C_(2)-PVP@DOXjade serves to promote apoptotic cell death and downregulate the iron depletion-induced iron transferrin receptor(TfR).A tumor pH-responsive iron chelation/photothermal/chemotherapy antitumor effect was achieved both in vitro and in vivo.The results of this study highlight what may constitute a promising iron chelation-based phototherapeutic approach to cancer therapy. | Yunjie Xu Yingwei Wang Jusung An Adam C.Sedgwick Mingle Li Jianlei Xie Weibin Hu Jianlong Kang Sajal Sen Axel Steinbrueck Bin Zhang Lijun Qiao Swelm Wageh Jonathan F.Arambula Liping Liu Han Zhang Jonathan L.Sessler Jong Seung Kim | 2022 | Bioactive Materials2022，7，8： | 2 |
| 8 | A novel method for elimination of inconsistencies in ordinal classification with monotonicity constraints显示文摘 | Deng Weibin Wang Guoyin Hu Feng | 2013 | Fundamenta Informaticae2013，126，4： | 1 |
| 9 | A Vero-cell-adapted vaccine donor strain of influenza A virus generated by serial passages显示文摘 | Weibin Hu Hong Zhang Qinglin Han Li Li Yixin Chen Ningshao Xia Ze Chen Yuelong Shu Ke Xu Bing Sun | 2014 | Vaccine2014，，： | 1 |
| 10 | Catalytic performance of MnO x –NiO composite oxide in lean methane combustion at low temperature显示文摘 | Yagang Zhang Zhangfeng Qin Guofu Wang Huaqing Zhu Mei Dong Shuna Li Zhiwei Wu Zhikai Li Zhonghua Wu Jing Zhang Tiandou Hu Weibin Fan Jianguo Wang | 2013 | Applied Catalysis B: Environmental2013，，： | 1 |
| 11 | Experimental Investigation on a Ceiling Capillary Radiant Heating System显示文摘 | Kang Weibin Zhao Min Liu Xing Meng Xiangzhao Zhang Lianying Hu Wangyang | 2015 | Energy Procedia2015，，： | 1 |
| 12 | HPV E6 induces eIF4E transcription to pro- mote the proliferation and migration of cervical cancer 显示文摘 | Sen Wang Tianyun Pang Min Gao Haixian Kang Weibin Ding Xiwen Sun Yi Zhao Wei Zhu Xudong Tang Yunhong Yao Xinrong Hu | 2013 | FEBS Lett2013，587，6： | 1 |
| 13 | Halophyte Vegetation Influences Soil Microbial Community of Coastal Salt Marsh显示文摘Coastal wetlands are the most productive ecosystems worldwide and can provide important ecosystem services,yet the characteristics of microbial community within these systems remain poorly understood.Microbial community of salt marsh vegetation and the associated soil physio-chemical properties were investigated in this study.Three typical Suaeda australis,Phragmites australis,Spartina alterniflora wetlands,and non-vegetated bare mudflats in the Zhoushan Islands were studied to advance the understanding of the characteristics of soil bacterial communities in coastal wetlands.Results showed that the bare mudflats exhibited high pH value and soil moisture content compared with the vegetated samples.In different vegetation types,the organic matter content,total nitrogen,and total potassium content decreased in the order:S.alterniflora wetland>P.australis wetland>S.australis wetland,and there was no obvious difference in total phosphorous content.The halophytes could decrease soil salinity compared with bare mudflats.Proteobacteria,Nitrospinae,Bacteroidetes,Acidobacteria,and Nitrospirae were the predominant level across all samples.Functional prediction showed that SPA-covered soil might play vital roles in sulphur cycling,while SUA and PHR covered soils were involved in nitrogen cycling.This study could provide the first insight into the microbial community of this study area and contribute to a better understanding of vegetation microbiota and bioremediation in coastal wetland ecosystem. | GU Chen SHI Jiyan RUI Jianliang YU Yanming HUANG Weibin LU Zhinai CHEN Yao CHEN Xiaojun DONG Shudi HU Zhijun YE Chenghua | 2022 | Journal of Ocean University of China2022，21，6： | 1 |
| 14 | Selective kernel networks for weakly supervised relation extraction显示文摘The purpose of relation extraction is to identify the semantic relations between entities in sentences that contain two entities.Recently,many variants of the convolution neural network(CNN)have been introduced to relation extraction for the extracting of features--the quality of the neural network model directly affects the final quality of relation extraction.However,the traditional convolution network uses a fixed convolution kernel,so it is difficult to choose the size of the convolution kernel dynamically,which results in networks with weak representation ability.To address this,a novel CNN is designed with selective kernel networks and multigranularity.In the process of feature extraction,the model can adaptively select the size of the convolution kernel,that is,give more weight to the appropriate convolution kernel.It is then combined with multigranularity convolution to obtain more abundant semantic information.Finally,a new pooling method is designed to obtain more comprehensive information and improve model performance.Experimental results indicate that this method is effective without excessively deep network layers,and it also outperforms several competitive baseline methods. | Ziyang Li Feng Hu Chilong Wang Weibin Deng Qinghua Zhang | 2021 | CAAI Transactions on Intelligence Technology2021，6，2： | 1 |
| 15 | Superenhancers activate the autophagy-related genes Beclin1 and LC3B to drive metastasis and drug resistance in osteosarcoma显示文摘Metastasis and drug resistance are the leading causes of poor prognosis in patients with osteosarcoma.Identifying the relevant factors that drive metastasis and drug resistance is the key to improving the therapeutic outcome of osteosarcoma.Here,we reported that autophagy was highly activated in metastatic osteosarcoma.We found increased autophagolysosomes in metastatic osteosarcoma cell lines by using electron microscopy,Western blot,and immunofluorescence experiments.We further examined the expression of the autophagy-related genes Beclin1 and LC3B in 82 patients through immunohistochemistry and found that Beclin1 and LC3B were highly related to unfavorable prognosis of osteosarcoma.Knockdown of Beclin1 and LC3B reduced invasion,metastasis,and proliferation in metastatic osteosarcoma cells.In vitro and in vivo studies also demonstrated that inhibiting by 3-MA inhibited cell growth and metastasis.Moreover,we demonstrated that autophagy-related genes were activated by SEs and that the inhibition of SEs by JQ-1 decreased the metastasis of osteosarcoma.Overall,our findings highlighted the association of autophagy with osteosarcoma progression and shed new light on autophagy-targeting therapy for osteosarcoma. | Hongyi Wang Zhuochao Liu Jun Wang Fangqiong Hu Qi Zhou Li Wei Qiyuan Bao Jizhuang Wang Jing Liang Zhihong Liu Weibin Zhang | 2022 | Frontiers of Medicine2022，16，6： | 0 |
| 16 | Nuclear phylogeny and insights into wholegenome duplications and reproductive development of Solanaceae plants显示文摘Solanaceae,the nightshade family,have2700 species,including the important crops potato and tomato,ornamentals,and medicinal plants.Several sequenced Solanaceae genomes show evidence for wholegenome duplication(WGD),providing an excellent opportunity to investigate WGD and its impacts.Here,we generated 93 transcriptomes/genomes and combined them with 87 public datasets,for a total of 180 Solanaceae species representing all four subfamilies and 14 of 15 tribes.Nearly 1700 nuclear genes from these transcriptomic/genomic datasets were used to reconstruct a highly resolved Solanaceae phylogenetic tree with six major clades.The Solanaceae tree supports four previously recognized subfamilies(Goetzeioideae,Cestroideae,Nicotianoideae,and Solanoideae)and the designation of three other subfamilies(Schizanthoideae,Schwenckioideae,and Petunioideae),with the placement of several previously unassigned genera.We placed a Solanaceae-specific whole-genome triplication(WGT1)at81 million years ago(mya),before the divergence of Schizanthoideae from other Solanaceae subfamilies at73 mya.In addition,we detected two gene duplication bursts(GDBs)supporting proposed WGD events and four other GDBs.An investigation of the evolutionary histories of homologs of carpel and fruit developmental genes in 14 gene(sub)families revealed that 21 gene clades have retained gene duplicates.These were likely generated by the Solanaceae WGT1 and may have promoted fleshy fruit development.This study presents a well-resolved Solanaceae phylogeny and a new perspective on retained gene duplicates and carpel/fruit development,providing an improved understanding of Solanaceae evolution. | Jie Huang Weibin Xu Junwen Zhai Yi Hu Jing Guo Caifei Zhang Yiyong Zhao Lin Zhang Christopher Martine Hong Ma Chien-Hsun Huang | 2023 | Plant Communications2023，4，4： | 0 |
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