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| 1 | Towards 6G wireless communication networks:vision,enabling technologies,and new paradigm shifts显示文摘The fifth generation(5G)wireless communication networks are being deployed worldwide from 2020 and more capabilities are in the process of being standardized,such as mass connectivity,ultra-reliability,and guaranteed low latency.However,5G will not meet all requirements of the future in 2030 and beyond,and sixth generation(6G)wireless communication networks are expected to provide global coverage,enhanced spectral/energy/cost efficiency,better intelligence level and security,etc.To meet these requirements,6G networks will rely on new enabling technologies,i.e.,air interface and transmission technologies and novel network architecture,such as waveform design,multiple access,channel coding schemes,multi-antenna technologies,network slicing,cell-free architecture,and cloud/fog/edge computing.Our vision on 6G is that it will have four new paradigm shifts.First,to satisfy the requirement of global coverage,6G will not be limited to terrestrial communication networks,which will need to be complemented with non-terrestrial networks such as satellite and unmanned aerial vehicle(UAV)communication networks,thus achieving a space-airground-sea integrated communication network.Second,all spectra will be fully explored to further increase data rates and connection density,including the sub-6GHz,millimeter wave(mmWave),terahertz(THz),and optical frequency bands.Third,facing the big datasets generated by the use of extremely heterogeneous networks,diverse communication scenarios,large numbers of antennas,wide bandwidths,and new service requirements,6G networks will enable a new range of smart applications with the aid of artificial intelligence(AI)and big data technologies.Fourth,network security will have to be strengthened when developing 6G networks.This article provides a comprehensive survey of recent advances and future trends in these four aspects.Clearly,6G with additional technical requirements beyond those of 5G will enable faster and further communications to the extent that the boundary between physical and cyber worlds disappears. | Xiaohu YOU Cheng-Xiang WANG Jie HUANG Xiqi GAO Zaichen ZHANG Mao WANG Yongming HUANG Chuan ZHANG Yanxiang JIANG Jiaheng WANG Min ZHU Bin SHENG Dongming WANG Zhiwen PAN Pengcheng ZHU Yang YANG Zening LIU Ping ZHANG Xiaofeng TAO Shaoqian LI Zhi CHEN Xinying MA Chih-Lin I Shuangfeng HAN Ke LI Chengkang PAN Zhimin ZHENG Lajos HANZO Xuemin(Sherman)SHEN Yingjie Jay GUO Zhiguo DING Harald HAAS Wen TONG Peiying ZHU Ganghua YANG Jun WANG Erik GLARSSON Hien Quoc NGO Wei HONG Haiming WANG Debin HOU Jixin CHEN Zhe CHEN Zhangcheng HAO Geoffrey Ye LI Rahim TAFAZOLLI Yue GAO HVincent POOR Gerhard P.FETTWEIS Ying-Chang LIANG | 2021 | Science China(Information Sciences)2021，64，1： | 122 |
| 2 | Strategies of minimally invasive treatment for intrahepatic and extrahepatic bile duct stones显示文摘 | Zongming Zhang Zhuo Liu Limin Liu Mengmeng Song Chong Zhang Hongwei Yu Baijiang Wan Mingwen Zhu Zixu Liu Hai Deng Haiming Yuan Haiyan Yang Wenping Wei Yue Zhao | 2017 | Frontiers of Medicine2017，11，4： | 37 |
| 3 | Efficiency and Inheritance of Targeted Mutagenesis in Maize Using CRISPR-Cas9显示文摘CRISPR/Cas(clustered regularly interspaced short palindromic repeats/CRISPR-associated proteins) is an adaptive immune system in bacteria and archaea to defend against invasion from foreign DNA fragments. Recently, it has been developed as a powerful targeted genome editing tool for a wide variety of species. However, its application in maize has only been tested with transiently expressed somatic cells or with a limited number of stable transgenic T0 plants. The exact efficiency and specificity of the CRISPR/Cas system in the highly complex maize genome has not been documented yet. Here we report an extensive study of the well-studied type II CRISPR-Cas9 system for targeted genome editing in maize, with the codon-optimized Cas9 protein and the short non-coding guide RNA generated through a functional maize U6 sn RNA promoter. Targeted gene mutagenesis was detected for 90 loci by maize protoplast assay, with an average cleavage efficiency of 10.67%. Stable knockout transformants for maize phytoene synthase gene(PSY1) were obtained. Mutations occurred in germ cells can be stably inherited to the next generation. Moreover, no off-target effect was detected at the computationally predicted putative off-target loci. No significant difference between the transcriptomes of the Cas9 expressed and non-expressed lines was detected. Our results confirmed that the CRISPR-Cas9 could be successfully applied as a robust targeted genome editing system in maize. | Jinjie Zhu Ning Song Silong Sun Weilong Yang Haiming Zhao Weibin Song Jinsheng Lai | 2016 | Journal of Genetics and Genomics2016，43，1： | 12 |
| 4 | Erucic acid from Isatis indigotica Fort. suppresses influenza A virus replication and inflammation in vitro and in vivo through modulation of NF-kB and p38 MAPK pathway显示文摘Isatis indigotica Fort.(Ban-Lan-Gen)is an herbal medicine prescribed for influenza treatment.However,its active components and mode of action remain mostly unknown.In the present study,erucic acid was isolated from Isatis indigotica Fort.,and subsequently its underlying mechanism against influenza A virus(IAV)infection was investigated in vitro and in vivo.Our results demonstrated that erucic acid exhibited broad-spectrum antiviral activity against IAV resulting from reduction of viral polymerase transcription activity.Erucic acid was found to exert inhibitory effects on IAV or viral(v)RNA-induced pro-inflam-matory mediators as well as interferons(IFNs).The molecular mechanism by which erucic acid with antiviral and anti-inflammatory properties was attributed to inactivation of NF-kB and p38 MAPK signaling.Furthermore,the NF-kB and p38 MAPK inhibitory effect of erucic acid led to diminishing the transcriptional activity of interferon-stimulated gene factor 3(ISGF-3),and thereby reducing IAV-triggered pro-inflammatory response amplification in IFN-β-sensitized cells.Additionally,IAV-or vRNA-triggered apoptosis of alveolar epithelial A549 cells was prevented by erucic acid.In vivo,erucic acid administration consistently displayed decreased lung viral load and viral antigens expression.Meanwhile,erucic acid markedly reduced CD8+cytotoxic T lymphocyte(CTL)recruitment,pro-apoptotic signaling,hyperactivity of multiple signaling pathways,and exacerbated immune inflammation in the lung,which resulted in decreased lung injury and mortality in mice with a mouse-adapted A/FM/1/47-MA(H1N1)strain infection.Our findings provided a mechanistic basis for the action of erucic acid against IAV-mediated inflammation and injury,suggesting that erucic acid may have a therapeutic potential in the treatment of influenza. | Xiaoli Liang Yuan Huang Xiping Pan Yanbing Hao Xiaowei Chen Haiming Jiang Jing Li Beixian Zhou Zifeng Yang | 2020 | Journal of Pharmaceutical Analysis2020，10，2： | 10 |
| 5 | Low-dose real-time X-ray imaging with nontoxic double perovskite scintillators显示文摘X-rays are widely used in probing inside information nondestructively,enabling broad applications in the medical radiography and electronic industries.X-ray imaging based on emerging lead halide perovskite scintillators has received extensive attention recently.However,the strong self-absorption,relatively low light yield and lead toxicity of these perovskites restrict their practical applications.Here,we report a series of nontoxic double-perovskite scintillators of Cs_(2)Ag_(0.6)Na_(0.4)In_(1-y)Bi_(y)Cl_(6).By controlling the content of the heavy atom Bi^(3+),the X-ray absorption coefficient,radiative emission efficiency,light yield and light decay were manipulated to maximise the scintillator performance.A light yield of up to 39,000±7000 photons/MeV for Cs_(2)Ag_(0.6)Na_(0.4)In_(0.85)Bi_(0.15)Cl_(6) was obtained,which is much higher than that for the previously reported lead halide perovskite colloidal CsPbBr_(3)(21,000 photons/MeV).The large Stokes shift between the radioluminescence(RL)and absorption spectra benefiting from self-trapped excitons(STEs)led to a negligible selfabsorption effect.Given the high light output and fast light decay of this scintillator,static X-ray imaging was attained under an extremely low dose of ∼1μGy_(air),and dynamic X-ray imaging of finger bending without a ghosting effect was demonstrated under a low-dose rate of 47.2μGy_(air) s^(−1).After thermal treatment at 85℃ for 50 h followed by X-ray irradiation for 50 h in ambient air,the scintillator performance in terms of the RL intensity and X-ray image quality remained almost unchanged.Our results shed light on exploring highly competitive scintillators beyond the scope of lead halide perovskites,not only for avoiding toxicity but also for better performance. | Wenjuan Zhu Wenbo Ma Yirong Su Zeng Chen Xinya Chen Yaoguang Ma Lizhong Bai Wenge Xiao Tianyu Liu Haiming Zhu Xiaofeng Liu Huafeng Liu Xu Liu Yang(Michael)Yang | 2020 | Light(Science & Applications)2020，9，1： | 9 |
| 6 | Gentiopicroside targets PAQR3 to activate the PI3K/AKT signaling pathway and ameliorate disordered glucose and lipid metabolism显示文摘The obstruction of post-insulin receptor signaling is the main mechanism of insulin-resistant diabetes.Progestin and adipoQ receptor 3(PAQR3),a key regulator of inflammation and metabolism,can negatively regulate the PI3 K/AKT signaling pathway.Here,we report that gentiopicroside(GPS),the main bioactive secoiridoid glycoside of Gentiana manshurica Kitagawa,decreased lipid synthesis and increased glucose utilization in palmitic acid(PA) treated HepG2 cells.Additionally,GPS improved glycolipid metabolism in streptozotocin(STZ) treated high-fat diet(HFD)-induced diabetic mice.Our findings revealed that GPS promoted the activation of the PI3 K/AKT axis by facilitating DNA-binding protein 2(DDB2)-mediated PAQR3 ubiquitinated degradation.Moreover,results of surface plasmon resonance(SPR),microscale thermophoresis(MST) and thermal shift assay(TSA) indicated that GPS directly binds to PAQR3.Results of molecular docking and cellular thermal shift assay(CETSA) revealed that GPS directly bound to the amino acids of the PAQR3 NH2-terminus including Leu40,Asp42,Glu69,Tyr125 and Ser129,and spatially inhibited the interaction between PAQR3 and the PI3 K catalytic subunit(P110α) to restore the PI3 K/AKT signaling pathway.In summary,our study identified GPS,which inhibits PAQR3 expression and directly targets PAQR3 to restore insulin signaling pathway,as a potential drug candidate for the treatment of diabetes. | Haiming Xiao Xiaohong Sun Zeyuan Lin Yan Yang Meng Zhang Zhanchi Xu Peiqing Liu Zhongqiu Liu Heqing Huang | 2022 | Acta Pharmaceutica Sinica B2022，12，6： | 7 |
| 7 | Refined chronology of prehistoric cultures and its implication for re-evaluating human-environment relations in the Hexi Corridor,northwest China显示文摘The reconstruction of high-resolution chronologies for prehistoric cultures is a prerequisite for understanding the history of human evolution and its relationship with environmental change, and is valuable for exploring the trajectory of transcontinental cultural exchanges in prehistoric time. The Hexi Corridor of northwest China was one of the earliest centers for long-distance culture exchange in the prehistoric world. The timing and sequence of cultural changes in this area remains poorly understood resulting from the lack of radiometric age control. This paper presents a refined radiocarbon(14 C) chronology to resolve the timing of human occupation and cultural evolution in the Hexi Corridor. Radiocarbon dating of crop remains, which have an annual life cycle, has the advantage of eliminating problems such as the carbon stored in ‘old wood’. As a result,14C dates from crop remains are used to test the validity of the14C dates derived from charcoal, bone and plant remains. The resultant database of ages is modelled using the Bayesian approach. The updated chronology presented in this paper shows generally good agreement with the original dates used to constrain cultural evolution in the Hexi Corridor. However, the occupation of the corridor by the Shajing and Shanma Late Bronze Age-Early Iron Age cultures appears to have taken place ~300 years later than previously thought. On the basis of comparing this updated chronology of cultural evolution with palaeoclimatic and historical records, it is proposed that the collapse of the Shajing and Shanma cultures occurred as a result of geopolitical impact rather than climate change. | Yishi YANG Shanjia ZHANG Chris OLDKNOW Menghan QIU Tingting CHEN Haiming LI Yifu CUI Lele REN Guoke CHEN Hui WANG Guanghui DONG | 2019 | Science China Earth Sciences2019，62，10： | 5 |
| 8 | Polybrominated diphenyl ether (PBDE) in blood from children (age 9–12) in Taizhou, China显示文摘Polybrominated diphenyl ethers (PBDEs) as ubiquitous persistent organic pollutants have attracted much attention in recent years. Exposure to PBDEs could induce a high health risk for children. The aim of this study was to investigate the PBDEs exposure of children (9–12 years) from Taizhou, China. Fifty-eight blood samples were collected in one school in a mountainous area in Taizhou. The concentrations of ∑9PBDEs (sum of BDE-28, -47, -99, -100, -153, -154, -183, -197 and -209) ranged from 2.66 to 33.9 ng/g lipid wet (lw) with a median of 7.22 ng/g lw. These concentrations were lower than those of children in USA, but close to European and Asian general population levels. The results showed that children in Taizhou countryside were at a low level of PBDEs exposure. The predominant congener was BDE-209, followed by BDE-28, -47, -197 and -153. High abundance of BDE-209 was consistent with the pollution background of PBDEs in China characterized by high brominated congeners as main pollutants. | Xiaoyou Zhang Xianli Ruan Minchan Yan Yaxian Zhao Wuji Wei Zhanfen Qin Yongjian Yang Haiming Xu Yan Li | 2011 | Journal of Environmental Sciences2011，23，7： | 5 |
| 9 | Gas stunning with CO_2 affected meat color,lipid peroxidation, oxidative stress, and gene expression of mitogen-activated protein kinases, glutathione S-transferases,and Cu/Zn-superoxide dismutase in the skeletal muscles of broilers显示文摘Background: Meat color and lipid peroxidation are important traits related to meat quality. CO_2 concentration is a critical factor that can affect meat quality in the commercial use of gas stunning(GS). However, the effect and mechanism of CO_2 stunning on meat color and lipid peroxidation during long-term storage remain poorly studied. We aimed to study the effects of GS methods, especial y CO_2 concentration, on meat color and meat lipid peroxidation in broilers during long-term storage at 4 °C and to explore the potential mechanism of meat color change via lipid peroxidation and the inner lipid peroxide scavenging system.Methods: Eighteen broilers were sacrificed after exposure to one of the following gas mixtures for 90 s: 40% CO_2+21% O_2+ 39% N2(G40%), 79% CO_2+ 21% O_2(G79%), or no stunning(0% CO_2, control). Meat color, serum variables,enzyme activities, and the gene expression of mitogen-activated protein kinase(MAPK), nuclear factor-erythroid2-related factor 2(Nrf2), glutathione S-transferase(GST) and superoxide dismutase(SOD) were determined.(Continued on next page)Results: The concentrations of serum triiodothyronine(T3, P = 0.03) and the ratio of serum free triiodothyronine/free thyroxine(FT3/FT4, P < 0.01) were decreased, whereas levels of serum cortisol(P < 0.01) were increased in the 40%CO_2 group compared with the control group. Additionally, the thiobarbituric acid-reactive substances(TBARS)3 d(P < 0.01) and TBARS6 d(P = 0.01) in breast meat and the TBARS3 din thigh meat(P < 0.01) were increased in the40% CO_2 group compared with the control group. Serum T3 was negatively correlated with TBARS6 dboth in the breast and thigh meat(r =-0.63, P < 0.01 and r =-0.47, P = 0.05 respectively). T3/T4 was negatively correlated with TBARS6 din the breast meat and in the thigh meat(r =-0.57, P = 0.01; and r =-0.53, P = 0.03 respectively). Compared with the control group, Lightness(L*)1 d(P = 0.03) and L*9 d(P < 0.01) were increased, whereas total chromatic aberration(E*)1 d(P = 0.05) and E*3 d(P < 0.01) were decreased in the breast meat of both the G40% and G79% groups. The values of yel owness(b*)3 d(P = 0.01), b*6 d(P < 0.01) and E*6 d(P < 0.01) in the thigh meat were lower in both the G40% and G79% groups than in the control group. In the breast muscle, the m RNA levels of c-Jun N-terminal kinase 2(JNK2, P = 0.03),GSTT1(P = 0.04), and SOD1(P = 0.05) were decreased, and the m RNA levels of JNK1(P = 0.07), Nrf2(P = 0.09), and GSTA3(P = 0.06) were slightly lower in both the G40% and G79% groups compared with the control group. However, among these genes, only the m RNA level of JNK1 was decreased in the G40% group compared with the control group and the G79% group(P = 0.03) in the thigh muscle.Conclusions: Compared with the control group, meat color quality in the breast meat was decreased, and the expression of genes in the MAPK/Nrf2/ARE(antioxidant responsive element) antioxidant pathway in breast muscle was partly suppressed by GS of both 40% and 79% CO_2. However, oxidative stress and meat lipid peroxidation during storage were aggravated by GS with 40% CO_2 compared to GS with 79% CO_2 and no GS. | Lei Xu Haijun Zhang Hongyuan Yue Shugeng Wu Haiming Yang Zhiyue Wang Guanghai Qi | 2018 | Journal of Animal Science and Biotechnology2018，9，3： | 5 |
| 10 | Seasonal timing of stratospheric final warming associated with the intensity of stratospheric sudden warming in preceding winter显示文摘The association of seasonal timing of stratospheric final warming events(SFWs) in spring and the occurrence of major and minor stratospheric sudden warming events(SSWs) in midwinter were investigated through statistical analysis, parallel comparison, and composite analysis, based on the NCEP-NCAR reanalysis dataset covering 1958–2012. It was found that the intensity and occurrence of winter SSW events can largely affect the timing of spring SFWs. Specifically, the SFW onset dates tend to be later(earlier) after the occurrence(absence) of winter major SSWs. However, the occurrence or absence of minor SSWs does not change the frequency of early and late SFWs. A parallel comparison of the temporal evolution of the anomalous circulation and planetary-waves between major SSW and minor SSW winters indicates that the stratospheric polar vortex(polar jet) will keep being anomalously stronger 30 days after major SSW onset. And the associated significant negative Eliassen-Palm(EP) flux anomalies can persist for as long as 45 days after major SSW events. In contrast, the circulation anomalies around the occurrence of minor SSW events can last only a few days. To further verify the possible influence of the occurrence of major SSWs on the seasonal timing of SFWs, composite analysis was performed respectively for the 21 major-SSW years, 15 minor-SSW years, and the 15 non-SSW years. Generally, planetary-wave activity in the extratropical stratosphere tends to be stronger(weaker) and the westerly polar jet is anomalously weaker(stronger) in major-SSW(non-SSW) winters. But in the following spring, the planetary-wave activity is weaker(stronger) accompanied with an anomalously stronger(weaker) stratospheric polar vortex. In spring after minor-SSW years, however, the stratospheric polar vortex and the westerly polar jet exhibit a state close to climatology with relatively gentle variations. | HU JingGao REN RongCai XU HaiMing YANG ShuangYan | 2015 | Science China Earth Sciences2015，58，4： | 4 |
| 11 | Features of underwater echo extraction based on signal sparse decomposition显示文摘为了更好认识到,鸣回响识别在水下有重重地不平的表面的材料,基于信号的理论,稀少的分解被建议了的一个特征抽象方法。而不是普通拍子频率字典,训练回响样品的集合直接被用作字典认识到回响在 L1 优化和摘要下面的稀少的分解回响的一种精力特征。包括钴外壳的三种底部材料的实验证明有这个方法的菲希尔分发比边特征并且在小浪领域的单个值分解 SVD 特征的优异。它无疑意味着那么更好的分类结果在水下底部材料能比其它与建议精力特征被获得二。因为一本字典是可行的,回响的班信息由这字典罐头帮助介绍获得更好的回响特征,回响样品使用了,这被结束因为一本字典是可行的。 | YANG Bo BU Yinyong ZHAO Haiming | 2012 | Chinese Journal of Acoustics2012，31，2： | 3 |
| 12 | Maize WI5 encodes an endo-1,4-β-xylanase required for secondary cell wall synthesis and water transport in xylem显示文摘Water transport from roots to leaves through xylem is important for plant growth and development.Defects in water transport can cause drought stress,even when there is adequate water in the soil.Here,we identi-fied the maize(Zea mays)wilty5(wi5)mutant,which ex-hibits marked dwarfing and leaf wilting throughout most of its life cycle under normal growth conditions.wilty5 seed-lings exhibited lower xylem conductivity and wilted more rapidly under drought,NaCl,and high temperature treat-ments than wild-type plants.Map-based cloning revealed that WI5 encodes an active endo-1,4-β-xylanase from gly-cosyl dehydration family 10,which mainly functions in degrading and reorganizing cell wall xylan.Reverse-transcription polymerase chain reaction andβ-glucuronidase assays revealed that WI5 is highly expressed in stems,especially in internodes undergoing secondary wall as-sembly.RNA sequencing suggested that WI5 plays a unique role in internode growth.Immunohistochemistry and electron microscopy confirmed that wi5 is defective in xylan deposition and secondary cell wall thickening.Lignin deposition and xylan content were markedly re-duced in wi5 compared to the wild-type plants.Our results suggest that WI5 functions in xylem cell wall thickening through its xylanase activity and thereby regulates xylem water transport,the drought stress response,and plant growth in maize. | Xiaojiao Hu Yang Cui Xiaomin Lu Weibin Song Lei Lei Jinjie Zhu Jinsheng Lai Lizhu E Haiming Zhao | 2020 | Journal of Integrative Plant Biology2020，62，10： | 3 |
| 13 | Optimization method for dynamics of non-holonomic system based on Gauss’ principle显示文摘The real-time control of the non-holonomic wheel robot has put forward higher requirements for the accuracy and speed of dynamical simulation,so it is necessary to study the new dynamic modeling and calculation methods adapting to modern information processingtechnology.Different from the traditional method solving differential-algebraic equation,the objective is to establish optimization model and effective calculating scheme for dynamics of non-holonomic system based on basic dynamical principle.The optimization model cannot be obtained directly from the traditional Gauss'principle.By using Gauss'principle of variational form,this paper deduces the minimum principle in the form of generalized coordinates and quasi-coordinates,respectively,thus allowing dynamical problems of non-holonomic systems to be incorporated into the framework of solving constrained or unconstrained optimization problems.Furthermore,we study a numerical calculation scheme that uses an optimization algorithm for the second form of the above optimization models.As an example,the dynamical problem of a differential-driven wheeled mobile-robot system is discussed.The optimization dynamic model of a non-holonomic robot system and the calculation model of the optimization algorithm are established.Comparing theresults of the optimization calculation with the differential-algebraic equations commonly used in dynamical problem for non-holonomic system reveals that the method in this paper is superior in terms of calculation speed and can more effectively handle constraint violations without extra constraint revision needed. | Wenli Yao Liusong Yang Kewei Song Haiming Wang | 2020 | Acta Mechanica Sinica2020，36，5： | 3 |
| 14 | Mineralization of aqueous pentachlorophenolate by anodic contact glow discharge electrolysis显示文摘Exhaustive mineralization of pentachlorophenolate ion(PCP) in phosphate buffer was carried out using anodic contact glow discharge electrolysis(CGDE),in which plasma was sustained between the electrolyte and anode.During CGDE,PCP degraded smoothly.The amount of total organic carbon decreased significantly,indicating the eventual conversion of the carbon atoms of benzene nucleus to inorganic carbons.Furthermore,chlorine atoms in PCP were liberated as chloride ions.As a primary intermediate product,2,3,5,6tetrachloro-1,4-benzoquinone was detected,and oxalate and formate as byproducts were also found.It was revealed that disappearance of PCP obeyed first-order kinetics.The reaction rate was generally unaffected by both O2 and inert gases in the cell,although it decreased by raising initial pH of solution.In addition,a plausible reaction pathway involving hydroxyl radical was proposed. | Haiming Yang Meguru Tezuka | 2011 | Journal of Environmental Sciences2011，23，6： | 3 |
| 15 | MDM2 SNP309 contributes to tumor susceptibility:A meta-analysis显示文摘潜在地功能的多型性, SNP309,在 MDM2 的倡导者区域,基因在出版研究看了不确定的结果的癌症风险,而是个人被含有。获得在 MDM2 SNP309 和癌症的风险之间的协会的更精确的估计,我们在与肿瘤和 33,046 控制的不同类型包括了 26,160 个盒子的 59 份出版物执行了 70 单个研究的元分析。概括机会比率(或) 并且相应当适当时, 95% 信心间隔(CI ) 用改正效果和随机效果的模型被估计。总的来说,变体遗传型在不同基因模型为所有癌症类型与显著地增加的癌症风险被联系(GG 对 TT:或, 1.123;95% CI, 1.0561.193;GG/GT 对 TT:或, 1.028;95% CI, 1.0061.050 ) 。在成层的分析,为大多数的研究仍然是的增加的风险癌症,亚洲人口,和医院打字 -- 在不同基因模型的 /population-based 研究,而显著地减少了,风险在前列腺癌症被发现(GG 对 TT:或, 0.606;95% CI, 0.4070.903;GG/GT 对 TT:或, 0.748;95% CI, 0.5790.968 ) 。在结论,元分析的数据建议 MDM2 SNP309 是为癌症风险的潜在的 biomarker。 | Xiaoman Wo Dong Han Haiming Sun Yang Liu Xiangning Meng Jing Bai Feng Chen Yang Yu Yan Jin Songbin Fu | 2011 | Journal of Genetics and Genomics2011，38，8： | 3 |
| 16 | Direct load control by distributed imperialist competitive algorithm显示文摘Demand side management techniques have drawn significant attentions along with the development of smart grid.This paper proposes a new direct load control(DLC)model for scheduling interruptible air conditioner loads.The model is coordinated with the unit commitment and economic dispatch to minimize the total operation cost over the whole dispatch horizon.The network constraints are also considered in the model.To ensure the thermal comfort of the occupants,we are among the first to incorporate the advanced two-parameter thermal inertia dynamical model of customer houses into the DLC model to calculate the indoor temperature variation.This paper also proposes a distributed imperialist competitive algorithm to effectively solve the model.The simulation studies prove the efficiency of the proposed methodology. | Fengji LUO Junhua ZHAO Haiming WANG Xiaojiao TONG Yingying CHEN Zhao Yang DONG | 2014 | Journal of Modern Power Systems and Clean Energy2014，2，4： | 3 |
| 17 | NaV6O15:A promising cathode material for insertion/extraction of Mg^2+with excellent cycling performance显示文摘The rechargeable magnesium batteries(RMBs)are getting more and more attention because of their high-energy density,high-security and low-cost.Nevertheless,the high charge density of Mg^2+makes the diffusion of Mg2+in the conventional cathodes very slow,resulting in a lack of appropriate electrode materials for RMBs.In this work,we enlarge the layer spacing of V2Os by introducing Na^2+in the crystal structure to promote the diffusion kinetics of Mg^2+.The NaVeO15(NVO)synthesized by a facile method is studied as a cathode material for RMBs with the anhydrous pure Mg^2+electrolyte.As a result,the NVO not only exhibits high discharge capacity(119.2 mAh:g^-1 after 100 cycles at the current density of 20 mA:g^-1)and working voltage(above 1.6 V vs.Mg^2+/Mg),but also expresses good rate capability.Besides,the eX-situ characterizations results reveal that the Mg^2+storage mechanism in NVO is based on the intercalation and deintercalation.The density functional theory(DFT)calculation results further indicate that Mg^2+tends to occupy the semi-occupied sites of Na^+in the NVO.Moreover,the galvanostatic intermittent titration technique(GITT)demonstrates that NVO electrode has the fast diffusion kinetics of Mg^2+during discharge process ranging from 7.55×10^-13 to2.41×10^-11 cm^2·s^-1.Our work proves that the NVO is a potential cathode material for RMBs. | Dongzheng Wu Jing Zeng Haiming Hua Junnan Wu Yang Yang Jinbao Zhao | 2020 | Nano Research2020，13，2： | 2 |
| 18 | Tocilizumab in patients with moderate or severe COVID-19: a randomized, controlled, open-label, multicenter trial显示文摘Tocilizumab has been reported to attenuate the“cytokine storm”in COVID-19 patients.We attempted to verify the effectiveness and safety of tocilizumab therapy in COVID-19 and identify patients most likely to benefit from this treatment.We conducted a randomized,controlled,open-label multicenter trial among COVID-19 patients.The patients were randomly assigned in a 1:1 ratio to receive either tocilizumab in addition to standard care or standard care alone.The cure rate,changes of oxygen saturation and interference,and inflammation biomarkers were observed.Thirty-three patients were randomized to the tocilizumab group,and 32 patients to the control group.The cure rate in the tocilizumab group was higher than that in the control group,but the difference was not statistically significant(94.12%vs.87.10%,rate difference 95%CI−7.19%–21.23%,P=0.4133).The improvement in hypoxia for the tocilizumab group was higher from day 4 onward and statistically significant from day 12(P=0.0359).In moderate disease patients with bilateral pulmonary lesions,the hypoxia ameliorated earlier after tocilizumab treatment,and less patients(1/12,8.33%)needed an increase of inhaled oxygen concentration compared with the controls(4/6,66.67%;rate difference 95%CI−99.17%to−17.50%,P=0.0217).No severe adverse events occurred.More mild temporary adverse events were recorded in tocilizumab recipients(20/34,58.82%)than the controls(4/31,12.90%).Tocilizumab can improve hypoxia without unacceptable side effect profile and significant influences on the time virus load becomes negative.For patients with bilateral pulmonary lesions and elevated IL-6 levels,tocilizumab could be recommended to improve outcome. | Dongsheng Wang Binqing Fu Zhen Peng Dongliang Yang Mingfeng Han Min Li Yun Yang Tianjun Yang Liangye Sun Wei Li Wei Shi Xin Yao Yan Ma Fei Xu Xiaojing Wang Jun Chen Daqing Xia Yubei Sun Lin Dong Jumei Wang Xiaoyu Zhu Min Zhang Yonggang Zhou Aijun Pan Xiaowen Hu Xiaodong Mei Haiming Wei Xiaoling Xu | 2021 | Frontiers of Medicine2021，15，3： | 2 |
| 19 | In-building coverage of millimeter-wave wireless networks from channel measurement and modeling perspectives显示文摘To progress cost-effective deployment of millimeter-wave(mm Wave)wireless networks for indoor users,the prediction of indoor-to-indoor(I2I)and outdoor-to-indoor(O2I)coverage based on field measurement studies is of great interest to the future generation mobile communication system.First,measurements in I2I and O2I scenarios,which have advantages in terms of achieving a fair comparison of channel characteristics across different mm Wave bands and bandwidths,are performed.Next,the developed dual-slope path loss model with a break-point distance is found to well fit omnidirectional and directional measured I2I data,especially at 39.5 GHz,revealing that the transition from lit or shadow regions to totally blocked regions is abrupt.Combined with space-time propagation characteristics,the indoor blockage effect on path loss and angular spread is investigated,therein being essential for the design of beam-steering and tracking algorithms.Double-directional measurement results show that most dominant paths arrive along the line-ofsight path,and only a few in-building reflections can be detected in higher frequency bands.Based on the joint analysis of channel measurement and modeling results,several mm Wave network design and in-building coverage enhancement insights are presented. | Peize ZHANG Cheng YI Bensheng YANG Cheng-Xiang WANG Haiming WANG Xiaohu YOU | 2020 | Science China(Information Sciences)2020，63，8： | 2 |
| 20 | The Geochemical and Zircon Trace Elements Characteristics of A-type Granitoids in Boziguoer, Baicheng County, Xinjiang显示文摘The Boziguoer A-type granitoids in Baicheng County,Xinjiang,belong to the northern margin of the Tarim platform as well as the neighboring EW-oriented alkaline intrusive rocks.The rocks comprise an aegirine or arfvedsonite quartz alkali feldspar syenite,an aegirine or arfvedsonite alkali feldspar granite,and a biotite alkali feldspar syenite.The major rock-forming minerals are albite,K-feldspar,quartz,arfvedsonite,aegirine,and siderophyllite.The accessory minerals are mainly zircon,pyrochlore,thorite,fluorite,monazite,bastnaesite,xenotime,and astrophyllite.The chemical composition of the alkaline granitoids show that SiO2varies from 64.55%to 72.29%with a mean value of 67.32%,Na2O+K2O is high(9.85%–11.87%)with a mean of 11.14%,K2O is 2.39%–5.47%(mean=4.73%),the K2O/Na2O ratios are 0.31–0.96,Al2O3ranges from 12.58%to 15.44%,and total FeO T is between 2.35%and 5.65%.CaO,MgO,MnO,and TiO2are low.The REE content is high and the total SREE is(263–1219)ppm(mean=776 ppm),showing LREE enrichment and HREE depletion with strong negative Eu anomalies.In addition,the chondrite-normalized REE patterns of the alkaline granitoids belong to the'seagull'pattern of the right-type.The Zr content is(113–1246)ppm(mean=594 ppm),Zr+Nb+Ce+Y is between(478–2203)ppm with a mean of 1362 ppm.Furthermore,the alkaline granitoids have high HFSE(Ga,Nb,Ta,Zr,and Hf)content and low LILE(Ba,K,and Sr)content.The Nb/Ta ratio varies from 7.23 to 32.59(mean=16.59)and the Zr/Hf ratio is 16.69–58.04(mean=36.80).The zircons are depleted in LREE and enriched in HREE.The chondrite-normalized REE patterns of the zircons are of the'seagull'pattern of the left-inclined type with strong negative Eu anomaly and without a Ce anomaly.The Boziguoer A-type granitoids share similar features with A1-type granites.The average temperature of the granitic magma was estimated at 832–839°C.The Boziguoer A-type granitoids show crust–mantle mixing and may have formed in an anorogenic intraplate tectonic setting under high-temperature,anhydrous,and low oxygen fugacity conditions. | LIU Chunhua YIN Jingwu WU Cailai SHAO Xingkun YANG Haitao XU Haiming WANG Jun | 2013 | Acta Geologica Sinica(English Edition)2013，87，6： | 2 |
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