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| 1 | Blocking FSH inhibits hepatic cholesterol biosynthesis and reduces serum cholesterol显示文摘Menopause is associated with dyslipidemia and an increased risk of cardio-cerebrovascular disease.The classic view assumes that the underlying mechanism of dyslipidemia is attributed to an insufficiency of estrogen.In addition to a decrease in estrogen, circulating follicle-stimulating hormone (FSH)levels become elevated at menopause.In this study,we find that blocking FSH reduces serum cholesterol via inhibiting hepatic cholesterol biosynthesis.First,epidemiological results show that the serum FSH levels are positively correlated with the serum total cholesterol levels,even after adjustment by considering the effects of serum estrogen,in addition,the prevalence of hypercholesterolemia is significantly higher in peri-menopausal women than that in premenopausal women.Furthermore,we generated a mouse model of FSH elevation by intraperitoneally injecting exogenous FSH into ovariectomized (OVX)mice,in which a normal level of estrogen (E2)was maintained by exogenous supplementation. Consistently,the results indicate that FSH,independent of estrogen,increases the serum cholesterol level in this mouse model. Moreover,blocking FSH signaling by anti-FSHβ antibody or ablating the FSH receptor (FSHR)gene could effectively prevent hypercholesterolemia induced by FSH injection or high-cholesterol diet feeding.Mechanistically,FSH,via binding to hepatic FSHRs, activates the Gi2α/β-arrestin-2/Akt pathway and subsequently inhibits the binding of FoxO1 with the SREBP-2 promoter,thus preventing FoxO1 from repressing SREBP-2 gene transcription.This effect,in turn,results in the upregulation of SREBP-2,which drives HMGCR nascent transcription and de novo cholesterol biosynthesis,leading to the increase of cholesterol accumulation.This study uncovers that blocking FSH signaling might be a new strategy for treating hypercholesterolemia during menopause, particularly for women in peri-menopause characterized by FSH elevation only. | Yanjing Guo Meng Zhao Tao Bo Shizhan Ma Zhongshang Yuan Wenbin Chen Zhao He Xu Hou Jun Liu Zhenhai Zhang Qiang Zhu Qiangxiu Wang Xiaoyan Lin Zhongli Yang Min Cui Lu Liu Yujie Li Chunxiao Yu Xiaoyi Qi Qian Wang Haiqing Zhang Qingbo Guan Lifang Zhao Shimeng Xuan Huili Yan Yanliang Lin Li Wang Qihang Li Yongfeng Song Ling Gao Jiajun Zhao | 2019 | Cell Research2019，29，2： | 16 |
| 2 | Vertical dynamic and thermodynamic characteristics of urban lower boundary layer and its relationship with aerosol concentration over Beijing显示文摘By utilizing observational data from a 325 m tower of the Institute of Atmospheric Physics (IAP), Chinese Academy of Sciences (CAS) on March 19-29, 2001 and August 11-25, 2003, a comprehensive study was conducted on the vertical dynamical and thermodynamic characteristics of the urban lower boundary layer (ULBL) and its relationship with aerosol concentration over Beijing. Firstly, a comparative analysis was made on the gradient data (wind, temperature and humidity), ultrasonic data (atmospheric turbulences) and air-quality observations at different tower heights (47, 120 and 280 m). Secondly, a diagnosis was made to reveal the major features of normalized variances of velocity and temperature, turbulence kinetic energy as well as their relationship with aerosol concentrations. Furthermore, the characteristics of the ULBL vertical structure and the TSP concentration/distribution variations during a sand/dust weather process were also analyzed. The outcome of the study showed that under unstable stratification, the normalized variances of velocity (σu/u*, σv/u*, σw/u*) and temperature (σT/T*) at 47 and 120 m heights fit the Monin-Obukhov similarity (MOS) framework and the fitting formulas were given out accordingly. According to the stratification parameter (z′/L), the stable ULBL could be divided into 2 zones. With z′/L<0.1, it was a weakly stable zone and MOS framework was applicable. The other was a highly stable zone with z′/L>0.1 and the normalized velocity variances tended to increase along with higher stability, but it remained constant for normalized temperature variances. At daytime, the near-surface layer includes two heights of 47 and 120 m, while 280 m has been above it. The ULBL analysis in conjunction with a sand/dust weather process in Beijing in March 2001 indicated that the maximum concentration of Total Suspended Particulates (TSP) at 320 m reached 913.3 μg/m3 and the particles were transported from the upper to lower ULBL, which was apparently related to the development process of a low-level jet and its concomitant strong sinking motion. | ZHOU Mingyu, YAO Wenqing, XU Xiangde & YU Haiqing State Key Laboratory on Severe Weather, Chinese Academy of Meteorological Sciences, Beijing 100081, China National Marine Environment Forecasting Center, Beijing 100081, China National Meteorological Center, Beijing 100081, China | 2005 | Science China Earth Sciences2005，48，z2： | 11 |
| 3 | Thickness-dependent patterning of MoS2 sheets with well-oriented triangular pits by heating in air显示文摘自从 MoS2 表的性质对边结构敏感,有常规边或可控制的形状的 Patterning ultrathin MoS2 层正在呼吁。在这个工作,我们介绍了一种简单、有效、控制得好的技术由简单地在空中加热样品与面向井的等边的三角形的坑蚀刻分层的 MoS2 表。各向异性的氧化蚀刻被包围温度和 MoS2 层的数字极大地影响,坑由此随包围温度和 MoS2 层的数字的增加缩放增加。第一原则的计算被执行了解释三角形的坑的形成机制。这种技术把一条其他的大街提供给设计 MoS2 表的结构。 | Haiqing Zhou Fang Yu Yuanyue Liu Xiaolong Zou Chunxiao Cong Caiyu Qiu Ting Yu Zheng Yan Xiaonan Shen Lianfeng Sun Boris I. Yakobson James M. Tour | 2013 | Nano Research2013，6，10： | 9 |
| 4 | High thermal conductivity of suspended few-layer hexagonal boron nitride sheets显示文摘推迟的很少层的热传导六角形的硼氮化物(h-BN ) 表试验性地用一个 noncontact micro-Raman 光谱学方法被调查。为单层(1L ) 的一阶的温度系数, bilayer (2L ) 并且九层(9L ) h-BN 表被测量是(当时, electrospinning 准备的 3.41 xide nanofibers 被期望减少了热电导率与体积样品相比。自从它包含复杂样品准备方法,热电导率正在质问的 nanofibers 的大小。在这个工作,我们在场对单个 nanofiber 的热电导率的大小合适的一个新奇方法。一 microelectro 机械(MEMS ) 设备被设计了并且制作了在单个 nanofiber 上执行热传导性大小。一个特殊 Si 模板被设计收集并且转单个 nanofibers 到 MEMS 设备名上吗? | Haiqing Zhou Jixin Zhu Zheng Liu Zheng Yan Xiujun Fan Jian Lin Gunuk Wang Qingyu Yan Ting Yu Pulickel M. Ajayan James M. Tour | 2014 | Nano Research2014，7，8： | 9 |
| 5 | Regulation of the inflammatory cycle by a controllable release hydrogel for eliminating postoperative inflammation after discectomy显示文摘Surgery is the final choice for most patients with intervertebral disc degeneration(IDD).Operation-caused trauma will cause inflammation in the intervertebral disc.Serious inflammation will cause tissue defects and induce tissue degeneration,IDD recurrence and the occurrence of other diseases.Therefore,we proposed a scheme to treat recurrence after discectomy by inhibiting inflammation with an aspirin(ASP)-loaded hydrogel to restore the mechanical stability of the spine and relieve local inflammation.ASP-liposomes(ASP-Lips)were incorporated into a photocrosslinkable gelatin-methacryloyl(GelMA)via mixing.This material can effectively alleviate inflammation by inhibiting the release of high mobility group box 1(HMGB1)from the nucleus to the cytoplasm.We further assessed the expression of inflammatory cytokines,such as interleukin 6(IL-6)and tumor necrosis factor-α(TNF-α),and degeneration-related factors,such as type II collagen(COL-2),Aggrecan,matrix metallopeptidases-3(MMP-3),MMP-13,a disintegrin and metalloproteinase with thrombospondin motifs-4(ADAMTS-4)and ADAMTS-5 in rat nucleus pulpous cells.The level of IDD was analyzed through H&E,safranin-O staining and immunohistochemistry in rabbit samples.In vitro,we found that ASP-Lip@GelMA treatment significantly decreased inflammatory cytokines,MMP-3 and-13,and ADAMTS-4 and-5 and up-regulated COL-2 and Aggrecan via the inhibited release of HMGB-1 from the nucleus.In vivo,ASP-Lip@GelMA can effectively inhibit inflammation of local tissue after disc surgery and fill local tissue defects.This composite hydrogel system is a promising way to treat the recurrence of IDD after surgery without persistent complications. | Yu Liu Jiacheng Du Peng Peng Ruoyu Cheng Jiayi Lin Congxin Xu Huilin Yang Wenguo Cui Haiqing Mao Yuling Li Dechun Geng | 2021 | Bioactive Materials2021，6，1： | 6 |
| 6 | A Numerical Study of the Aerodynamic Characteristics of a High-Speed Train under the Effect of Crosswind and Rain显示文摘The performances of high-speed trains in the presence of coupling effects with crosswind and rain have attracted great attention in recent years.The objective of the present paper was to investigate the aerodynamic characteristics of a high-speed train under such conditions in the framework of an Eulerian-Lagrangian approach.An aerodynamic model of a high-speed train was first set up,and the side force coefficient obtained from numerical simulation was compared with that provided by wind tunnel experiments to verify the accuracy of the approach.Then,the effects of the yaw angle,the resultant wind speed,and the rainfall rate on aerodynamic coefficients were analyzed.The results indicate that the aerodynamic coefficients grow almost linearly with the rainfall rate,and increase with a decrease in the resultant wind speed.Due to the impact of raindrops on the train surface and the airflow,the pressure coefficients of windward and leeward side of the train become larger with the increase of the rainfall rate.Raindrops can accelerate the airflow and suppress the vortices detachment.Moreover,the flow velocity in regions surrounding the train increases with an increase in the rainfall rate. | Haiqing Li Mengge Yu Qian Zhang Heng Wen | 2020 | Fluid Dynamics & Materials Processing2020，16，1： | 6 |
| 7 | Overall optimization of high-speed semiconductor laser modules显示文摘Based on the high frequency techniques such as frequency response measurement,equivalent circuit modeling and packaging parasitics compensation,a comprehensive optimization method for packaging high-speed semiconductor laser module is presented in this paper.The experiments show that the small-signal magnitude frequency response of the TO packaged laser module is superior to that of laser diode in frequencies,and the in-band flatness and the phase-frequency linearity are also improved significantly. | LIU Yu CHEN ShuoFu WANG Xin YUAN HaiQing XIE Liang ZHU NingHua | 2009 | Chinese Science Bulletin2009，54，20： | 6 |
| 8 | Optimization of environmental variables in habitat suitability modeling for mantis shrimp Oratosquilla oratoria in the Haizhou Bay and adjacent waters显示文摘Habitat suitability index(HSI)models have been widely used to analyze the relationship between species abundance and environmental factors,and ultimately inform management of marine species.The response of species abundance to each environmental variable is different and habitat requirements may change over life history stages and seasons.Therefore,it is necessary to determine the optimal combination of environmental variables in HSI modelling.In this study,generalized additive models(GAMs)were used to determine which environmental variables to be included in the HSI models.Significant variables were retained and weighted in the HSI model according to their relative contribution(%)to the total deviation explained by the boosted regression tree(BRT).The HSI models were applied to evaluate the habitat suitability of mantis shrimp Oratosquilla oratoria in the Haizhou Bay and adjacent areas in 2011 and 2013–2017.Ontogenetic and seasonal variations in HSI models of mantis shrimp were also examined.Among the four models(non-optimized model,BRT informed HSI model,GAM informed HSI model,and both BRT and GAM informed HSI model),both BRT and GAM informed HSI model showed the best performance.Four environmental variables(bottom temperature,depth,distance offshore and sediment type)were selected in the HSI models for four groups(spring-juvenile,spring-adult,falljuvenile and fall-adult)of mantis shrimp.The distribution of habitat suitability showed similar patterns between juveniles and adults,but obvious seasonal variations were observed.This study suggests that the process of optimizing environmental variables in HSI models improves the performance of HSI models,and this optimization strategy could be extended to other marine organisms to enhance the understanding of the habitat suitability of target species. | Yunlei Zhang Huaming Yu Haiqing Yu Binduo Xu Chongliang Zhang Yiping Ren Ying Xue Lili Xu | 2020 | Acta Oceanologica Sinica2020，39，6： | 5 |
| 9 | Global Uranium Resources in Sedimentary Basins and the Characteristics of Oil, Gas, Coal and Uranium Coexisting in one Basin显示文摘1 Sedimentary-type and Sandstone-type Uranium Resources Over the past three decades,with the success in in-situ leach(ISL)mining of sandstone-type uranium deposits(SUD),the quantity,resources and production | WANG Feifei LIU Chiyang NIU Haiqing DENG Yu MA Huanhuan WANG Wenqing | 2017 | Acta Geologica Sinica(English Edition)2017，91，S1： | 3 |
| 10 | Some basic questions on helicity inferred from vector magnetograms显示文摘This paper summarizes current helicity measurements in the solar active regions (ARs). There is a basic agreement with the 'hemispheric sign rule (HSR)' of the current helicity among different vector magnetographs through two solar cycles, but there is a large dispersion of the fraction of ARs following the HSR. In our sample, there are 50%-78% ARs in solar cycle 22 and 44%-79% ARs in cycle 23 following the HSR. A variation is also found in the fraction of the ARs following the HSR between different instruments even when the same ARs are selected. The difference also exists for the same instrument when the selected ARs are different. There are some differences in the variation of HSR with solar cycle for the individual helicity parameter inferred from different instruments. Factors which influence the correlation of different data sets are analyzed. | XU HaiQing GAO Yu ZHANG HongQi | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，11： | 2 |
| 11 | Boosting pH-Universal Hydrogen Evolution of Molybdenum Disulfide Particles by Interfacial Engineering显示文摘The design of high-efficiency non-noble and earth-abundant electrocatalysts for hydrogen evolution reaction(HER)is highly paramount for water splitting and renewable energy systems.Molybdenum disulfide(MoS_(2))with abundant edge sites can be utilized as a promising alternative,but its catalytic activity is greatly related to the pH values,especially in an alkaline environment due to the extremely high energy barriers for water adsorption and dissociation steps.Here we report an exceptionally efficient and stable electrocatalyst to improve the sluggish HER process of layered MoS_(2)particles in different pH electrolytes,especially in base.The electrocatalyst is constructed by in situ growing selenium-doped MoS_(2)(Se-MoS_(2))nanoparticles on three-dimensional cobalt nickel diselenide(mCo_(0.2)Ni_(0.8)Se_(2))nanostructured arrays.Due to the large number of active edge sites of Se-MoS_(2)particles exposed at the surface,robust electrical conductivity and large surface area of mCo_(0.2)Ni_(0.8)Se_(2)support,and strong interfacial interactions between Se-MoS_(2)and mCo_(0.2)Ni_(0.8)Se_(2),this hybrid catalyst shows very outstanding catalytic HER properties featured by low overpotentials of 30 and 122 mV at 10 and 100 mA/cm^(2)with good operational stability in base,respectively,which outperforms most of inexpensive catalysts consisting of layered MoS_(2),transition metal selenides and sulfides,and it performs as well as noble Pt catalysts.Meanwhile,this electrocatalyst is also very active in neutral and acidic electrolytes,requiring low overpotentials of 93 and 94 mV at 10 mA/cm^(2),respectively,demonstrating its superb pH universality as a HER electrocatalyst with excellent catalytic durability.This study provides a straightforward strategy to construct an efficient non-noble electrocatalyst for driving the HER kinetics in different electrolytes. | Liling Liao Lun Yang Gang Zhao Haiqing Zhou Fengming Cai Yi Li Xiuzhang Wang Fang Yu | 2021 | Chinese Journal of Chemistry2021，39，2： | 2 |
| 12 | Studies on the properties of surface and edges of N-layer graphenes显示文摘Graphene, a new two-dimensional carbon material, is a rising star of physics, chemistry and materials science. In this work, we report the recent experimental researches on the Raman spectra and the temperature-dependent features of graphenes and car- bon nanoscrolls, which are evolved from graphene and have an open tubular structure. The layer-dependent Raman enhancing characteristics of n-layer graphenes for crystal violet, and the thickness-dependent morphologies of gold on n-layer graphenes are also systematically investigated. Meanwhile, the aggregations of ferromagnetic and paramagnetic atoms at edges of gra- phenes and graphite are observed and the mechanisms are discussed. | CHEN MinJiang ZHOU HaiQing QIU CaiYu YANG HuaiChao YU Fang SUN LianFeng | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，10： | 2 |
| 13 | Operational Safety Assessment of a High-Speed Train Exposed to the Strong Gust Wind显示文摘The operational safety characteristics of trains exposed to a strong wind have caused great concern in recent years.In the present paper,the effect of the strong gust wind on a high-speed train is investigated.A typical gust wind model for any wind angle,named“Chinese hat gust wind model”,was first constructed,and an algorithm for computing the aerodynamic loads was elaborated accordingly.A vehicle system dynamic model was then set up in order to investigate the vehicle system dynamic characteristics.The assessment of the operational safety has been conducted by means of characteristic wind curves(CWC).As some of the parameters of the wind-train system were difficult to measure,we also investigated the impact of the uncertain system parameters on the CWC.Results indicate that,the descending order of the operational safety index of the vehicle for each wind angle is 90°-60°-120°-30°-150°,and the worst condition for the operational safety occurs when the wind angle reaches around 90°.According to our findings,the gust factor and aerodynamic side force coefficient have great impact on the critical wind speed.Thus,these two parameters require special attention when considering the operational safety of a railway vehicle subjected to strong gust wind. | Mengge Yu Zhenkuan Pan Jiali Liu Haiqing Li | 2020 | Fluid Dynamics & Materials Processing2020，16，1： | 1 |
| 14 | High current density M-type cathodes for vacuum electron devices显示文摘 | Ji Li Zhiqiang Yu Wensheng Shao Ke Zhang Yujuan Gao Haiqing Yuan Hui Wang Kaizhi Huang Qilue Chen Suqiu Yan Shaolun Cai | 2005 | Applied Surface Science2005，，1： | 1 |
| 15 | Selective Recursive Kernel Learning for Online Identification of Nonlinear Systems with NARX Form显示文摘 | LIU Yi WANG Haiqing YU Jiang | | 0，，02： | 1 |
| 16 | An ahemating elution strategy for screening high af- finity peptides from a phage display peptide library 显示文摘 | Yu Haiqing | 2004 | Bio- chemical Engineering Journal2004，，18： | 1 |
| 17 | Specific Regulation of m^(6)A by SRSF7 Promotes the Progression of Glioblastoma显示文摘Serine/arginine-rich splicing factor 7(SRSF7),a known splicing factor,has been revealed to play oncogenic roles in multiple cancers.However,the mechanisms underlying its oncogenic roles have not been well addressed.Here,based on N6-methyladenosine(m^(6)A)co-methylation network analysis across diverse cell lines,we find that the gene expression of SRSF7 is positively correlated with glioblastoma(GBM)cell-specific m^(6)A methylation.We then indicate that SRSF7 is a novel m^(6)A regulator,which specifically facilitates the m^(6)A methylation near its binding sites on the mRNAs involved in cell proliferation and migration,through recruiting the methyltransferase complex.Moreover,SRSF7 promotes the proliferation and migration of GBM cells largely dependent on the presence of the m^(6)A methyltransferase.The two m^(6)A sites on the mRNA for PDZ-binding kinase(PBK)are regulated by SRSF7 and partially mediate the effects of SRSF7 in GBM cells through recognition by insulin-like growth factor 2 mRNA-binding protein 2(IGF2BP2).Together,our discovery reveals a novel role of SRSF7 in regulating m^(6)A and validates the presence and functional importance of temporal-and spatial-specific regulation of m^(6)A mediated by RNA-binding proteins(RBPs). | Yixian Cun Sanqi An Haiqing Zheng Jing Lan Wenfang Chen Wanjun Luo Chengguo Yao Xincheng Li Xiang Huang Xiang Sun Zehong Wu Yameng Hu Ziwen Li Shuxia Zhang Geyan Wu Meisongzhu Yang Miaoling Tang Ruyuan Yu Xinyi Liao Guicheng Gao Wei Zhao Jinkai Wang Jun Li | 2023 | Genomics, Proteomics & Bioinformatics2023，21，4： | 1 |
| 18 | Nobiletin: efficient and large quantity isolation from orange peel extract显示文摘 | L1 Shiming YU Haiqing HO C T | 2006 | Biomedical Chromatography2006，20，1： | 1 |
| 19 | Nobiletin: efficient andlarge quantity isolation from orange peel extract显示文摘 | LI Shiming YU Haiqing HO C T | 2006 | BiomedicalChromatography2006，20，1： | 1 |
| 20 | A full numerical solution for general transient elastohydrodynamic line contact and its application 显示文摘 | Ai Xiaolan Yu Haiqing | 1988 | Wear1988，121，： | 1 |
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