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| 1 | Ferroptosis:molecular mechanisms and health implications显示文摘Cell death can be executed through different subroutines.Since the description of ferroptosis as an iron-dependent form of nonapoptotic cell death in 2012,there has been mounting interest in the process and function of ferroptosis.Ferroptosis can occur through two major pathways,the extrinsic or transporter-dependent pathway and the intrinsic or enzyme-regulated pathway.Ferroptosis is caused by a redox imbalance between the production of oxidants and antioxidants,which is driven by the abnormal expression and activity of multiple redox-active enzymes that produce or detoxify free radicals and lipid oxidation products.Accordingly,ferroptosis is precisely regulated at multiple levels,including epigenetic,transcriptional,posttranscriptional and posttranslational layers.The transcription factor NFE2L2 plays a central role in upregulating anti-ferroptotic defense,whereas selective autophagy may promote ferroptotic death.Here,we review current knowledge on the integrated molecular machinery of ferroptosis and describe how dysregulated ferroptosis is involved in cancer,neurodegeneration,tissue injury,inflammation,and infection. | Daolin Tang Xin Chen Rui Kang Guido Kroemer | 2021 | Cell Research2021，31，2： | 182 |
| 2 | Enhanced efficiency of generating induced pluripotent stem (iPS) cells from human somatic cells by a combination of six transcription factors显示文摘 | Jing Liao Zhao Wu Ying Wang Lu Cheng Chun Cui Yuan Gao Taotao Chen Lingjun Rao Siye Chen Nannan Jia Huiming Dai Shunmei Xin Jiuhong Kang Gang Pei Lei Xiao | 2008 | Cell Research2008，18，5： | 61 |
| 3 | RNA-seq analysis of prostate cancer in the Chinese population identifies recurrent gene fusions, cancer-associated long noncoding RNAs and aberrant alternative splicings显示文摘在有前列腺癌症的不同赛跑的病人之中有显著不同;然而,位于这差别下面的机制仍然保持不清楚。这里,我们在场 transcriptome 的一处全面风景用 RNA-seq,越过关于基因熔化的前列腺癌症 transcriptomes 的揭示巨大的差异,长 noncoding RNA (长 ncRNA ) ,其他的拼接和体的变化从中国人口 14 主要前列腺癌症和他们的配对的正常对应物介绍。14 个肿瘤(21.4%) 中的三个在中国病人怀有 TMPRSS2 尔格熔化,和这熔化的低流行进一步在一个另外的肿瘤集合(10/54=18.5%) 被证实。尤其是,二新奇基因熔化, CTAGE5-KHDRBS3 (20/54=37%) 和 USP9Y-TTTY15 (19/54=35.2%) ,在我们的耐心的队经常发生了。介绍的进一步系统的 transcriptional 识别了是在肿瘤表示的差别的众多的长 ncRNAs。在长 ncRNA 和基因的表示之间的关联的分析建议长 ncRNAs 可以在 transcriptional 规定以外有功能。这研究在中国人口产出新卓见进前列腺癌症的致病。 | Shancheng Ren Zhiyu Peng Jian-Hua Mao Yongwei Yu Changjun Yin Xin Gao Zilian Cui Jibin Zhang Kang Yi Weidong Xu Chao Chen Fubo Wang Xinwu Guo Ji Lu Jun Yang Min Wei Zhijian Tian Yinghui Guan Liang Tang Chuanliang Xu Linhui Wang Xu Gao Wei Tian Jian Wang Huanming Yang Jun Wang Yinghao Sun | 2012 | Cell Research2012，22，5： | 66 |
| 4 | Pachytene piRNAs instruct massive mRNA elimination during late spermiogenesis显示文摘在哺乳动物的精子发生被 piRNA 表示的二个波浪描绘:一个人对应于负责的经典 piRNAs 因为 silencing retrotransponsons 和第二个波浪主要在 pachytene spermatocytes 从 nontransposon intergenic 区域被导出,但是这些 pachytene piRNAs 的功能大部分是未知的。这里,我们在在老鼠伸长指示巨大的 mRNA 消除报导 pachytene piRNAs 的参与 spermatids (ES ) 。我们证明包含鼠科的 PIWI (MIWI ) 和 deadenylase CAF1 的导致 piRNA 的 silencing 建筑群(pi-RISC ) 有选择地在 ES 被装配,它负责经由在体的房间类似于 miRNAs 的行动的机制导致 mRNA deadenylation 和腐烂。如此的一个高度安排的节目看起来充分利用 pachytene piRNAs 的能力从 nontransposon intergenic 区域导出的多样化的指向的庞大的全部剧目。这些调查结果建议 pachytene piRNAs 负责为精子生产作准备,从 ES 使广阔细胞的节目失去活性。 | Lan-Tao Gou Peng Dai Jian-Hua Yang Yuanchao Xue Yun-Ping Hu Yu Zhou Jun-Yan Kang Xin Wang Hairi Li Min-Min Hua Shuang Zhao Si-Da Hu Li-Gang Wu Hui-Juan Shi Yong Li Xiang-Dong Fu Liang-Hu Qu En-Duo Wang Mo-Fang Liu | 2014 | Cell Research2014，24，6： | 39 |
| 5 | Terrestrial carbon sinks in China and around the world and their contribution to carbon neutrality显示文摘Enhancing the terrestrial ecosystem carbon sink(referred to as terrestrial C sink) is an important way to slow down the continuous increase in atmospheric carbon dioxide(CO_(2)) concentration and to achieve carbon neutrality target.To better understand the characteristics of terrestrial C sinks and their contribution to carbon neutrality,this review summarizes major progress in terrestrial C budget researches during the past decades,clarifies spatial patterns and drivers of terrestrial C sources and sinks in China and around the world,and examines the role of terrestrial C sinks in achieving carbon neutrality target.According to recent studies,the global terrestrial C sink has been increasing from a source of (-0.2±0.9) Pg C yr^(-1)(1 Pg=1015g)in the 1960s to a sink of (1.9±1.1) Pg C yr^(-1) in the 2010s.By synthesizing the published data,we estimate terrestrial C sink of 0.20–0.25 Pg C yr^(-1) in China during the past decades,and predict it to be 0.15–0.52 Pg C yr^(-1) by 2060.The terrestrial C sinks are mainly located in the mid-and high latitudes of the Northern Hemisphere,while tropical regions act as a weak C sink or source.The C balance differs much among ecosystem types:forest is the major C sink;shrubland,wetland and farmland soil act as C sinks;and whether the grassland functions as C sink or source remains unclear.Desert might be a C sink,but the magnitude and the associated mechanisms are still controversial.Elevated atmospheric CO_(2) concentration,nitrogen deposition,climate change,and land cover change are the main drivers of terrestrial C sinks,while other factors such as fires and aerosols would also affect ecosystem C balance.The driving factors of terrestrial C sink differ among regions.Elevated CO_(2) concentration and climate change are major drivers of the C sinks in North America and Europe,while afforestation and ecological restoration are additionally important forcing factors of terrestrial C sinks in China.For future studies,we recommend the necessity for intensive and long-term ecosystem C monitoring over broad geographic scale to improve terrestrial biosphere models for accurately evaluating terrestrial C budget and its dynamics under various climate change and policy scenarios. | Yuanhe Yang Yue Shi Wenjuan Sun Jinfeng Chang Jianxiao Zhu Leiyi Chen Xin Wang Yanpei Guo Hongtu Zhang Lingfei Yu Shuqing Zhao Kang Xu Jiangling Zhu Haihua Shen Yuanyuan Wang Yunfeng Peng Xia Zhao Xiangping Wang Huifeng Hu Shiping Chen Mei Huang Xuefa Wen Shaopeng Wang Biao Zhu Shuli Niu Zhiyao Tang Lingli Liu Jingyun Fang | 2022 | Science China(Life Sciences)2022，65，5： | 32 |
| 6 | Circulating miRNAs as biomarkers for severe acute pancreatitis associated with acute lung injury显示文摘AIM To identify circulating micro(mi)RNAs as biological markers for prediction of severe acute pancreatitis(SAP) with acute lung injury(ALI).METHODS Twenty-four serum samples were respectively collected and classified as SAP associated with ALI and SAP without ALI, and the mi RNA expression profiles were determined by microarray analysis. These mi RNAs were validated by quantitative reverse transcriptionpolymerase chain reaction, and their putative targets were predicted by the online software Target Scan, mi Randa and Pic Tar database. Gene ontology(GO) and Kyoto encyclopedia of genes and genomes(commonly known as KEGG) were used to predict their possible functions and pathways involved.RESULTS We investigated 287 mi RNAs based on microarray data analysis. Twelve mi RNAs were differentially expressed in the patients with SAP with ALI and those with SAP without ALI. Hsa-mi R-1260 b, 762, 22-3 p, 23 b and 23 a were differently up-regulated and hsa-mi R-550 a*, 324-5 p, 484, 331-3 p, 140-3 p, 342-3 p and 150 were differently down-regulated in patients with SAP with ALI compared to those with SAP without ALI. In addition, 85 putative target genes of the significantly dysregulated mi RNAs were found by Target Scan, mi Randa and Pic Tar. Finally, GO and pathway network analysis showed that they were mainly enriched in signal transduction, metabolic processes, cytoplasm and cell membranes.CONCLUSION This is the first study to identify 12 circulating mi RNAs in patients with SAP with ALI, which may be biomarkers for prediction of ALI after SAP. | Xiao-Guang Lu Xin Kang Li-Bin Zhan Li-Min Kang Zhi-Wei Fan Li-Zhi Bai | 2017 | World Journal of Gastroenterology2017，23，41： | 21 |
| 7 | Heart failure and left ventricular dysfunction in older patients with chronic kidney disease: the China Hypertension Survey (2012‒2015)显示文摘Background Heart failure(HF)is a leading cause of hospitalization and mortality for older chronic kidney disease(CKD)patients.However,the epidemiological data is scarce.We aimed to determine the prevalence of left ventricular(LV)dysfunction and HF,and to explore the risk factors for HF among those patients.Methods This is a cross-sectional analysis of the China Hypertension Survey conducted between October 2012 and December 2015.A total of 5,808 participants aged≥65 years were included in the analysis.Self-reported history of HF and any other cardiovascular diseases was acquired.2-D and Doppler echocardiography were used to assess LV dysfunction.CKD was defined as either estimated glomerular filtration rate(eGFR)<60 mL/min per 1.73 m2 or urinary albumin to creatinine ratio(ACR)≥30 mg/g.Results Among CKD patients aged≥65 years,the weighted prevalence of HF,heart failure with preserved ejection fraction(HFpEF),heart failure with mid-range ejection fraction(HFmrEF),and heart failure with reduced ejection fraction(HFrEF)was 4.8%,2.5%,0.8%,and 1.7%,respectively.The weighted prevalence of HF was 5.0%in patients with eGFR<60 mL/min per 1.73 m2,and was 5.9%in patients with ACR≥30 mg/g.The prevalence of LV systolic dysfunction was 3.1%,and while it was 8.9%for moderate/severe diastolic dysfunction.Multivariate analysis showed that smoking was significantly associated with the risk of HF.Furthermore,age,smoking,and residents in rural areas were significantly associated with a risk of LV diastolic dysfunction.Conclusions The prevalence of HF and LV dysfunction was high in older patients with CKD,suggesting that particular strategies will be required. | Xin WANG Guang HAO Lu CHEN Lin-Feng ZHANG Zuo CHEN Yu-Ting KANG Ying YANG Cong-Yi ZHENG Hao-Qi ZHOU Zeng-Wu WANG Run-Lin GAO | 2020 | Journal of Geriatric Cardiology2020，17，10： | 19 |
| 8 | Laparoscopic-endoscopic cooperative surgery for gastric submucosal tumors显示文摘AIM:To assess the feasibility,safety,and advantages of minimally invasive laparoscopic-endoscopic cooperative surgery(LECS)for gastric submucosal tumors(SMT).METHODS:We retrospectively analyzed 101 consecutive patients,who had undergone partial,proximal,or distal gastrectomy using LECS for gastric SMT at Peking Union Medical College Hospital from June 2006to April 2013.All patients were followed up by visit or telephone.Clinical data,surgical approach,pathological features such as the size,location,and pathological type of each tumor;and follow-up results were analyzed.The feasibility,safety and effectiveness of LECS for gastric SMT were evaluated,especially for patients with tumors located near the cardia or pylorus.RESULTS:The 101 patients included 43(42.6%)menand 58(57.4%)women,with mean age of 51.2±13.1 years(range,14-76 years).The most common symptom was belching.Almost all(n=97)patients underwent surgery with preservation of the cardia and pylorus,with the other four patients undergoing proximal or distal gastrectomy.The mean distance from the lesion to the cardia or pylorus was 3.4±1.3 cm,and the minimum distance from the tumor edge to the cardia was 1.5 cm.Tumor pathology included gastrointestinal stromal tumor in 78 patients,leiomyoma in 13,carcinoid tumors in three,ectopic pancreas in three,lipoma in two,glomus tumor in one,and inflammatory pseudotumor in one.Tumor size ranged from 1 to8.2 cm,with 65(64.4%)lesions<2 cm,32(31.7%)>2 cm,and four>5 cm.Sixty-six lesions(65.3%)were located in the fundus,21(20.8%)in the body,10(9.9%)in the antrum,three(3.0%)in the cardia,and one(1.0%)in the pylorus.During a median follow-up of 28 mo(range,1-69 mo),none of these patients experienced recurrence or metastasis.The three patients who underwent proximal gastrectomy experienced symptoms of regurgitation and belching.CONCLUSION:Laparoscopic-endoscopic cooperative surgery is feasible and safe for patients with gastric submucosal tumor.Endoscopic intraoperative localization and support can help preserve the cardia and pylorus during surgery. | Wei-Ming Kang Jian-Chun Yu Zhi-Qiang Ma Zi-Ran Zhao Qing-Bin Meng Xin Ye | 2013 | World Journal of Gastroenterology2013，19，34： | 17 |
| 9 | Experimental Study on Heat Transfer and Pressure Drop Characteristics of Four Types of Plate Fin-and-TUbe Heat Exchanger Surfaces显示文摘ExperimentalStudyonHeatTransferandPressureDropCharacteristicsofFourTypesofPlateFin-and-TUbeHeatExchangerSurfaces￥H.J.Kang;W.L... | H.J. Kang W. Li H.Z. Li R.C. Xin W.Q. Tao(School of Energy and Power Engineering, Xi’an Jiaotong University, Xi’an, Shaanxi 710049, China) | 1994 | Journal of Thermal Science1994，3，1： | 17 |
| 10 | Susceptibility-weighted Imaging in Thrombolytic Therapy of Acute Ischemic Stroke显示文摘 | Lin Li Ming-Su Liu Guang-Qin Li Yang Zheng Tong-Li Guo Xin Kang Mao-Ting Yuan | 2017 | Chinese Medical Journal2017，，20： | 15 |
| 11 | Mid-short-term risk assessment of power systems considering impact of external environment显示文摘Ice flashover,lightning flashover and bird damage are the main reasons that cause transmission facility failure.The impact of these environmental factors on the operational risk levels of power systems should be taken into account in power system maintenance scheduling and operation planning.This paper studies the midshort-term risk assessment methodology considering the impact of the external environment.The relationship model between natural disasters and transmission lines is presented.The conditional outage rate model and the sampling technique are then proposed considering the correlated outage of multiple transmission lines when a disaster happens.The framework of the mid-short-term risk assessment model is outlined.A test case of Jiangxi provincial power grid validates the proposed model.The results show that the model can quantify the impact of disasters on the forced outage rate of transmission component and their outage correlation,and thus effectively revealing the mid-short-term risk of power systems.The model can facilitate a more strategic decision-making on maintenance scheduling and operation planning of power systems. | Ning ZHANG Chongqing KANG Jingkun LIU Jianbo XIN Junbiao WAN Jing HU Wenxiao WEI | 2013 | Journal of Modern Power Systems and Clean Energy2013，1，2： | 14 |
| 12 | Binding Activity Difference of Anti-CD20 scFv-Fc Fusion Protein Derived from Variable Domain Exchange显示文摘Two novel engineered antibody fragments binding to antigen CD20 were generated by fusing a murine IgM-type anti-CD20 single-chain Fv fragment (scFv) to the human IgG1 CH2 (i.e., Cγ2) and CH3 (i.e., Cγ3) domains with the human IgG1 hinge (i.e. Hγ). Given the relationship between structure and function of protein, the 3-D structures of the two engineered antibody fragments were modeled using computer-aided homology modeling method. Furthermore, the relationship between 3-D conformation and their binding activity was evaluated theoretically. Due to the change of active pocket formed by CDRs, the HL23 (VH-Linker-VL-Hγ-Cγ2-Cγ3) remained its activity because of its preserved conformation, while the binding activity of the LH23 (VL-Linker-VH-Hγ-Cγ2-Cγ3) was impaired severely. Experimental studies by flow cytometry and fluorescence microscopy showed that HL23 possessed significantly superior binding activity to CD20-expressing target cells than LH23. That is to say, the order of variable regions could influence the binding activity of the fusion protein to CD20+ cell lines, which was in accordance with the theoretical results. The study highlights the potential relationship between the antibody binding activity and their 3-D conformation, which appears to be worthwhile in providing direction for future antibody design of recombinant antibody. | Shusheng Geng Jiannan Feng Yan Li Yingxun Sun Xin Gu Ying Huang Yugang Wang Xianjiang Kang Hong Chang Beifen Shen | 2006 | Cellular & Molecular Immunology2006，3，6： | 13 |
| 13 | A novel synthesis strategy to improve cycle stability of LiNio.8Mno.1Co0.1O2 at high cut-off voltages through core-shell structuring显示文摘Nickel-rich cathode materials have attracted considerable interest because of their high specific capacities,voltage ranges,and low cost.However,serious capacity attenuation and poor rate performance limit their application.This study proposes a novel strategy to improve the cycle stability of the nickel-rich LiNi0.sCo0.1Mn0.1O2(NCM811)layer material by designing core-shell LiNio.sCoo.1 Mno.102(CS-NCM811).CS-NCM811 is designed by the characteristic reaction between dimethylglyoxime(C4H8N2O2)and nickel ion to form Ni(C4H7N2O2)2-The CS-NCM811 is characterized with high nickel content in its core and high manganese content on its surface,leading to a high capacity and excellent cycle stability.The capacity retention of CS-NCM811 was 72.8%,much higher than that of NCM811(47.1%)after 500 cycles at a rate of 5 C.Not only is this method a no vel strategy to desig n high capacity cathode materials but also provides some new in sights into the cycle stability of nickel-rich layered cathode materials. | Kang Wu Qi Li Rongbin Dang Xin Deng Minmin Chen Yu Lin Lee Xiaoling Xiao Zhongbo Hu | 2019 | Nano Research2019，12，10： | 12 |
| 14 | Evidence for a recent warming and wetting in the source area of the Yellow River (SAYR) and its hydrological impacts显示文摘在分水岭规模的气候变化调查在在分水岭揭示历史的进化和流量变化的未来趋势起一个重要作用。这研究从 1961 ~ 2012 在黄河(SAYR ) 的来源区域上检验 multisource 水文学和气象学的变量并且在这个区域的未来气候情形在 20062100 期间基于 CMIP5 设计数据。它在 SAYR 认出最近的气候变化的重要特征并且在这个区域预言未来流动的变化趋势。(1 ) 自从 2000 年代初,在 SAYR 的气候经历了一个重要温暖湿的变化,这被发现,自从 1980 年代末,它与先前的温暖干燥的趋势很不同;(2 ) 在西北的 SAYR 的温暖湿的趋势(黄河(HAYR ) 的 headwater 区域,在整个 SAYR 是比那更明显的;(3 ) 与降水增加,自从 2006,在这个区域的流量也经历了一个增加的过程。在这个区域的流量变化对降水,宠物和最大的空气温度的变化敏感,然而并非对在吝啬、最小的空气温度的变化很敏感;(4 ) 基于 CMIP5 设计数据,如果认为三不同,在 SAYR 的温暖湿的气候趋势是可能的继续直到 2049 (即 RCP2.6, RCP4.5 和 RCP8.5 ) 在 SAYR 的温室气体排放情形,和降水不是不到在 2100 前的当前的水平;然而, SAYR 的最近的流动增加是可能的是十的变化,它将至多继续直到 2020 年代,这被估计;(5 ) 东方亚洲冬季季风的内部年度的变化被发现是仔细与在这个区域的年度降水的变化有关。同时,增加的降水以及是远的潜在的土壤水分蒸发蒸腾损失总量(宠物) 的增加不到在最近的时期的降水的是为这个区域的流动增加的主要气候原因。 | TIAN Hui LAN Yongchao WEN Jun JIN Huijun WANG Chenghai WANG Xin KANG Yue | 2015 | Journal of Geographical Sciences2015，25，6： | 12 |
| 15 | Esophagojejunostomy after laparoscopic total gastrectomy by Or VilTM or hemi-double stapling technique显示文摘AIM: To investigate the feasibility, advantages and disadvantages of two types of anvil insertion techniques for esophagojejunostomy after laparoscopic total gastrectomy.METHODS: This was an open-label prospective cohort study. Laparoscopy-assisted radical total gastrectomy with D2 lymph node dissection was performed in 84 patients with primary non-metastatic gastric cancer confirmed by pre-operative histological examination. Overweight patients were excluded, as well as patients with peritoneal dissemination and invasion of adjacent organs. After total gastrectomy, all patients were randomized into two groups. Patients in Group Ⅰ underwent esophagojejunostomy using a transorally-inserted anvil(Or VilTM), while patients in Group Ⅱ underwent esophagojejunostomy using the hemi-double stapling technique(HDST). Both types of esophagojejunostomy were performed under laparoscopy. Patients' baseline characteristics, preoperative characteristics, perioperative characteristics, short-term postoperative outcomes and operation cost were comparedbetween the two groups. The primary endpoint was evaluation of the surgical outcome(operating time, time of digestive tract reconstruction and time of anvil insertion) and the medical cost of each operation(operation cost and total cost of hospitalization). The secondary endpoints were time to solid diet, post-surgical hospitalization time, time to defecation, time to ambulation and intra-operative blood loss. In addition, complications were assessed and compared. RESULTS: Laparoscopic total gastrectomy and esophagojejunostomy were successfully performed in all 84 patients, without conversion to laparotomy. There were no significant differences in the operative time and time for total gastrectomy between the two groups(287.8 ± 38.4 min vs 271.8 ± 46.1 min, P = 0.09, and 147.7 ± 31.6 min vs 159.8 ± 33.8 min, P = 0.09, respectively). The time for digestive tract reconstruction and for anvil insertion were significantly decreased in Group Ⅱ compared with Group I(47.8 ± 12.1 min vs 55.4 ± 15.7 min, P = 0.01, and 12.6 ± 4.7 min vs 18.7 ± 7.5 min, P = 0.001, respectively). Intraoperative blood loss(96.4 ± 32.7 m L vs 88.2 ± 36.9 m L, P = 0.28), time to defecation(3.5 ± 0.9 d vs 3.2 ± 1.1 d, P = 0.12), time to ambulation(3.9 ± 0.7 d vs 3.6 ± 1.1 d, P = 0.12), time to solid diet(7.6 ± 1.4 d vs 8.0 ± 2.7 d, P = 0.31) and total hospitalization(10.6 ± 2.6 d vs 10.8 ± 3.5 d, P = 0.80) were similar between the two groups. In addition, the total costs of hospitalization were similar between the two groups(73848.7 ± 11781.0 RMB vs 70870.3 ± 14003.5 RMB, P = 0.296), but operation cost was significantly higher in Group I compared with Group Ⅱ(32401.9 ± 1981.6 RMB vs 26961.9 ± 2293.8 RMB, P < 0.001).CONCLUSION: Anvil insertion was faster and easier using the HDST technique compared with Or VilTM, and was more cost-effective. There was no significant difference in safety. | Hao Wang Qun Hao Meng Wang Min Feng Feng Wang Xin Kang Wen-Xian Guan | 2015 | World Journal of Gastroenterology2015，21，29： | 12 |
| 16 | Dynamic CCT Diagram of Automobile Beam Steel With High Strength Produced by FTSR Technology显示文摘The dynamic continuous cooling transformation(CCT)diagram and phase transformation rules of 510 MPa automobile beam steel,which is produced by a continuous casting of thin slab of FTSR technology in Tangshan Iron and Steel Co.Ltd.,are researched by thermal simulation experiment.The microstructure characteristics of the beam steel under different test conditions are studied by means of optical microscope and scanning electron microscope.The test results show that the critical temperatures of phase transformation Ar3 and Ar1 will all decrease with the increase of the cooling rate.When the cooling rate is lower than 20 ℃·s-1,the ferrite and pearlite phase transformations are the main parts;when the cooling rate is higher than 20 ℃·s-1,the bainite phase appears.Moreover,the microstructures of 510 MPa automobile beam steel produced by FTSR technology are also studied,and the results are basically in accordance with the CCT diagram gained from the test. | WANG Xin KANG Yong-lin YU Hao CHEN Li-bin KONG Qing-fu | 2008 | Journal of Iron and Steel Research(International)2008，15，2： | 11 |
| 17 | Gene and mutation independent therapy via CRISPR-Cas9 mediated cellular reprogramming in rod photoreceptors显示文摘 | Zhu, Jie Ming, Chang Fu, Xin Duan, Yaou Duc Anh Hoang Rutgard, Jeffrey Zhang, Runze Wang, Wenqiu Hou, Rui Zhang, Daniel Zhang, Edward Zhang, Charlotte Hao, Xiaoke Xiong, Wenjun Zhang, Kang | 2017 | Cell Research2017，27，6： | 11 |
| 18 | Use of tailored loading-dose clopidogrel in patients undergoing selected percutaneous coronary intervention based on adenosine diphosphate-mediated platelet aggregation显示文摘背景腺苷调停磷酸盐的血小板聚集是为在经历了选择经皮的冠的干预的病人的主要不利心脏的事件的一个预示的因素。试图估计 clopidogrel 的调整装载剂量是否能更有效地在经历的病人禁止血小板聚集的这研究选择了经皮的冠的 intervention.Methods 经历选择经皮的冠的干预的 205 个病人的一个总数在这 multicenter 被注册,未来的、使随机化的学习。收到国内 clopidogrel (n=104 ) 的病人担任了 Talcom (Taijia ) 组;其它(n=101 ) 收到了 Plavix, Plavix 组,病人们收到了腺苷直到装载 clopidogrel 的剂量到减少的 3 另外的 300-mg 在超过 50% 的调停磷酸盐的血小板聚集索引(主要端点) 与基线相比。第二等的端点与合理装载剂量相比是在 12 months.Results 的主要不利心血管的事件,定制的装载剂量更好在腺苷基于 50% 减少禁止了血小板聚集调停磷酸盐的血小板聚集(合理装载剂量对定制的装载剂量, 48% 对 73% , P=0.028 ) 。在在 Talcom 和 Plavix 组之间的合格索引没有重要差别(47% 对 49% 在 300 mg;62% 对 59% 在 600 mg;74% 对 72% 在 900 mg;P 0.05 ) 基于标准腺苷 50% 的调停 diphosphate 的血小板聚集减少。在 12 月后续以后,在主要不利心脏的事件没有重要差别(2.5% 对 2.9% , P=5.43 ) 。没有尖锐或稍尖的 stent 血栓事件 occurred.Conclusion clopidogrel 的调整装载剂量能与合理剂量相比在 antiplatelet 聚集上有重要效果,减少的 1 年的专业在基于腺苷经历经皮的冠的干预的病人的不利心脏的事件没有流血的增加的调停磷酸盐的血小板聚集。 | MENG Kang LV Shu-zheng ZHU Hua-gang CHEN Xin GE Chang-jiang SONG Xian-tao | 2010 | Chinese Medical Journal2010，，24： | 11 |
| 19 | Temperature field distribution of burnt surrounding rock in UCG stope显示文摘In order to study temperature field distribution in burnt surrounding rock and to determine ranges of burnt surrounding rock, coal-wall coking cycle and heat influence in the underground coal gasification(UCG) stope, based on the Laplace transform and inversion formula, we studied the temperature analytical solution of one-dimensional unsteady heat conduction for multi-layer overlying strata under the first and the forth kinds of boundary conditions, and we also carried out a numerical simulation of twodimensional unsteady heat conduction by the COMSOL multiphysics. The results show that when the boundary temperature of surrounding rock has a linear decrease because of a directional movement of heat source in the UCG flame working face, the temperature in surrounding rock increases first and then decreases with time, the peak of temperature curve decreases gradually and its position moves inside surrounding rock from the boundary. In the surrounding rock of UCG stope, there is an envelope curve of temperature curve clusters. We analyzed the influence of thermophysical parameters on envelope curves and put forward to take envelope curve as the calculation basis for ranges of burnt surrounding rock, coal-wall coking cycle and heat influence. Finally, the concrete numerical values are given by determining those judgement standards and temperature thresholds, which basically tally with the field geophysical prospecting results. | Xin Lin Wang Zuotang Huang Wengang Kang Guojun Lu Xuefeng Zhang Peng Wang Jianhua | 2014 | International Journal of Mining Science and Technology2014，24，4： | 10 |
| 20 | Combined effect of atorvastatin and probucol on plasma cystatin C levels and severity of coronary lesion in patients with borderline coronary lesion显示文摘 | GE Chang-jiang LU Shu-zheng FENG Li-xia HUO Yong SONG Xian-tao CHEN Xin MENG Kang YUAN Fei | 2012 | Chinese Medical Journal2012，，14： | 10 |
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