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| 1 | Depletion of activated hepatic stellate cell correlates with severe liver damage and abnormal liver regeneration in acetaminophen-induced liver injury显示文摘肝的星形的房间(HSC ) 是为肝的祖先房间(HPC ) 和 hepatocytes 的本地干细胞壁龛的重要部分。然而,它至于激活的 HSC 的产品是否被要求稀释 hepatocyte 损害是不清楚的,提高肝新生,或两个。在这研究,我们由弄空执行了功能研究的损失有 gliotoxin 的激活的 HSC。显著地严重的肝损坏和拒绝的幸存率与激活的 HSC 的弄空被相关,这被表明。而且,减少 HSC 激活导致了增殖的 hepatocytes 的数字的 hepatocyte apoptosis 和 66% 减少的 3 褶层增加。这被戏剧的减少在知道在 hepatocyte 复制期间起来调整的五基因的表示层次伴随。特别地,激活的 HSC 的弄空禁止了被 Pank 积极的房间的减少的数字在道和降低的基因表示 cytokeratin 铺平的门附近证实的卵形的房间反应,这被发现 19 (CK19 ) 在对待 gliotoxin 的肝。这些数据提供激活的 HSC 涉及 hepatocyte 死亡和 hepatocytes 的增长,在 acetaminophen (APAP ) 的 HPC 导致了尖锐的肝损害的清楚的证据。 | Kuntang Shen Wenju Chang Xiaodong Gao Hongshan Wang Weixin Niu Lujun Song Xinyu Qin | 2011 | Acta Biochimica et Biophysica Sinica2011，43，4： | 13 |
| 2 | Fault diagnosis of wind turbine bearing based on stochastic subspace identification and multi-kernel support vector machine显示文摘In order to accurately identify a bearing fault on a wind turbine, a novel fault diagnosis method based on stochastic subspace identification(SSI) and multi-kernel support vector machine(MSVM) is proposed. Firstly, the collected vibration signal of the wind turbine bearing is processed by the SSI method to extract fault feature vectors. Then, the MSVM is constructed based on Gauss kernel support vector machine(SVM) and polynomial kernel SVM. Finally, fault feature vectors which indicate the condition of the wind turbine bearing are inputted to the MSVM for fault pattern recognition. The results indicate that the SSI-MSVM method is effective in fault diagnosis for a wind turbine bearing and can successfully identify fault types of bearing and achieve higher diagnostic accuracy than that of K-means clustering, fuzzy means clustering and traditional SVM. | Hongshan ZHAO Yufeng GAO Huihai LIU Lang LI | 2019 | Journal of Modern Power Systems and Clean Energy2019，7，2： | 12 |
| 3 | MiR-320a downregulation is associated with imatinib resistance in gastrointestinal stromal tumors显示文摘胃肠的 stromal 肿瘤(大意) 是胃肠的道的最普通的间充质的肿瘤之一。尽管 imatinib 改进结果,药抵抗为扩大耐心的幸存仍然是主要问题。药目标的基因变化是为 imatinib 抵抗的已知的机制。然而,它不能 imatinib 抵抗的现象解释所有,并且众多的另外的机制被建议了在各种各样的模型系统说明 imatinib 抵抗。在这研究,我们使用了屏蔽差别的基于反应的数组途径表示了的 SYBR 绿的量的聚合酶链在主要大意病人和 imatinib 抵抗的病人之间的 miRNAs。选择候选人 miRNAs 在 12 个大意病人的一个队被验证。我们发现 miR-320a 的那低表情与 imatinib 抵抗的短时间被相关,并且为 imatinib 抵抗建议了 miR-320a 的潜在的机制。 | Xiaodong Gao Kuntang Shen Cuizhong Wang Jiaqian Ling Hongshan Wang Yong Fang Yuan Shi Yingyong Hou Jin Qin Yihong Sun Xinyu Qin | 2014 | Acta Biochimica et Biophysica Sinica2014，46，1： | 9 |
| 4 | Fluvial terraces and their implications for Weihe River valley evolution in the Sanyangchuan Basin显示文摘Fluvial terraces are important geomorphic markers for modern valley development.When coupled with numeric ages,terraces can provide abundant information about tectonic,climatic,paleohydrological and the paleoenvironmental changes.On the basis of the paleomagnetic,electron spin resonance(ESR) and optically stimulated luminescence(OSL) dating,in addition to an investigation of local loess-paleosol sequences,we confirmed that 13 fluvial terraces were formed,and then preserved,along the course of the Upper Weihe River in the Sanyangchuan Basin over the past 1.2 Ma.Analyses of the characteristics and genesis of these terraces indicate that they resulted from the response of this particular river system to climate change over an orbital scale.These changes can further be placed within the context of local and regional tectonic uplift,and represent an alternation between lateral migration and vertical incision,dependent upon the predominance of climatic and tectonic controls during different periods.Most of the terraces are strikingly similar in that they have several meters of paleosols which have developed directly on top of fluvial deposits located on the terrace treads,suggesting that the abandonment of terraces due to river incision occurred during the transitions from glacial to interglacial climates.The temporal and spatial differences in the distribution patterns of terraces located on either side of the river valley indicate that a tectonic inversion occurred in Sanyangchuan Basin at-0.62 Ma,and that this was characterized by a transition from overall uplift to depression induced by fault activity.Synthesized studies of the Basin's terraces indicate that formation of the modern valley of the Upper Weihe River may have begun in the late Early Pleistocene between1.4-1.2 Ma. | GAO HongShan LI ZongMeng LIU XiaoFeng PAN BaoTian WU YaJie LIU FenLiang | 2017 | Science China Earth Sciences2017，60，3： | 9 |
| 5 | Terrace dating as an archive of the run-through of the Sanmen Gorges显示文摘Analysis of morphological properties in the Sanmen Gorges region of the Yellow River shows that four river terraces have been developed at the entrance to the gorges. Commonly, thick aeolian loess-paleosol sequence was deposited on the terraces, which makes it easy to date the terraces. The dating of paleomagnetic, loess-paleosol sequence matching and thermoluminescence show that terraces T2, T3 and T4 were formed 0. 129 Ma, 0. 625 Ma and 0. 865 Ma ago, respectively. The formation of these terraces in this region indicates that the Yellow River has experienced four intensive downcutting events during the last 0.9 Ma. The Yellow River cut through the Sanmen Gorges and inpoured into the East China Sea no later than 0. 865 Ma. | PAN Baotian WANG Junping GAO Hongshan CHEN Yingying LI Jijun LIU Xiaofeng | 2005 | Progress in Natural Science:Materials International2005，15，12： | 9 |
| 6 | DNA methylation and chromatin accessibility profiling of mouse and human fetal germ cells显示文摘染色质改变为人的初发的细菌房间的 epigenetic reprogramming 是重要的。然而,全面染色质状态还没为人的胎儿的细菌房间(FGC ) 被分析了。这里,我们使用 nucleosome 占有和 methylation 定序方法在人和老鼠在胎儿的细菌房间开发期间在一系列关键时间点分析染色体宽的染色质可接近性和 DNA methylome。我们在人和老鼠 FGC 发现 116 887 和 137 557 个弄空 nucleosome 的区域(NDR ) ,盖住 germline 特定、高度有活力的规章的 genomic 元素的一个大集合,例如 enhancers。而且,我们发现远侧的 NDR 在人的 FGC 为象 NANOG , SOX17 , AP2 和 OCT4 那样的 pluripotency 和细菌房间主人管理者的有约束力的主题明确地被充实,显示在pluripotency相关的基因和细菌之间的精细的规章的平衡的存在在人的 FGC 的房间特定的基因,并且为在 vivo 的细菌房间开发的这些基因的功能的意义。我们的工作为把提供一张全面、高分辨率的路线图染色质状态转变动力学在人和老鼠 FGC 的 epigenomic reprogramming 期间。 | Hongshan Guo Boqiang Hu Liying Yan Jun Yong Yan Wu Yun Gao Fan Guo Yu Hou Xiaoying Fan Ji Dong Xiaoye Wang Xiaohui Zhu Jie Yan Yuan Wei Hongyan Jin Wenxin Zhang Lu Wen FuchouTang Jie Qiao | 2017 | Cell Research2017，27，2： | 9 |
| 7 | Quantitative analysis of planation surfaces of the upper Yangtze River in the Sichuan-Yunnan Region, Southwest China显示文摘Identification of the planation surfaces (PSs)is key for utilizing them as a reference in studying the long- term geomorphological evolution of the Upper Yangtze River Basin in the Sichuan-Yurman region,Southwest China.Using a combined method of DEM-based fuzzy logic and topographic and fiver profiles analysis and based on a comprehensive analysis of four morphometfic parameters:slope,curvature,terrain raggedness index, and relative height,we established the relevant fuzzy membership functions,and then calculated the membership degree (MD)of the study area.Results show that patches with a MD>80% and an area>0.4 km^2 correspond well to the results of Google Earth and field investigation,representing the PS remnants.They consist of 1764 patches with an altitude,area,mean slope,and relief of mostly 2000-2500 m above sea level (asl),0-10 km^2,4°-9°,0-500 m,respectively,covering 9.2% of the study area's landscape,dipping to southeast,decreasing progressively from northwest to southeast in altitude,and with no clear relation between each patch's altitude and slope,or relief.All these results indicate that they are remnants of once regionally continuous PSs which were deformed by both the lower crust flow and the faults in upper crust,and dissected by the network of Upper Yangtze River.Additionally,topographic and river profiles analysis show that three PSs (PS1-PS3)well developed along the main valleys in the Yongren-Huili region, indicating several phases of uplift then planation during the Late Cenozoic era.Based on the incision amount deduced from projection of relict river profiles on PSs, together with erosion rates,breakup times of the PS 1,PS2,and PS3 were estimated to be 3.47 Ma,2.19 Ma,and 1.45 Ma,respectively,indicating appearance of modem Upper Yangtze River valley started between the Pliocene to early Pleistocene. | Fenliang LIU Hongshan GAO Baotian PAN Zongmeng LI Huai SU | 2019 | Frontiers of Earth Science2019，13，1： | 7 |
| 8 | Dating and genesis of the upper Weihe River terraces in Longxi basin,China显示文摘Seven terraces along the Weihe River in Longxi basin have been investigated. These terraces all consist of archetypal duality in structure, namely the floodplain deposits and the layer of gravels overlaid by varying thickness of the loess. By resorting to various dating approaches such as palaeomagnetic, optically stimulated luminescenece (OSL), 14C and loess-paleosol sequence, we provide preliminary timing of these seven terraces along upper Weihe River. Analysis on sedimentation characteristics and dating of these terraces showed that seven terraces may be jointly generated by tectonic uplifts and climatic changes. Tectonic uplifts may accommodate initial river incision, and climatic change may be responsible for processes of subsequent channel widening and aggradation. Aggradation normally occurs during glacial periods, in contrast to down-cuttings during transitions from glacial to interglacial period. Moreover, on the basis of the timings and heights of these terraces, we infer that the long-term rate of river incision was determined to be 0.2 m/kyr during the last 870 kyr, which differs from other river incision rates. This discrepancy may reflect spatio-temporal differentiation of tectonic activities in the Qinling orogenic belt during the Pleistocene. | Pan Baotian Liu Xiaofeng Gao Hongshan Wang Yong Li Jijun | 2007 | Progress in Natural Science:Materials International2007，17，11： | 7 |
| 9 | Sulfide mineral dissolution microbes: Community structure and function in industrial bioleaching heaps显示文摘Heap bioleaching is one of the most clean and economical processes for recovery of low-grade and complex ores, because the sulfide minerals are natural habitats for acidophiles capable of iron-and sulfur-oxidation. The most exciting advances in heap bioleaching are occurring in the field of microbiology, especially with the development of advanced molecular biology approaches. These chemolithotrophic microorganisms living in the acid mine environment fix N_2 and CO_2 and obtain energy for growth from soluble ferrous iron and reduced inorganic sulfur compounds during oxidation of sulfide minerals. The ferric iron as oxidant and sulfuric acid are a result of microbial activity and provide favorable conditions for the dissolution of sulfide minerals. Various microbial consortia were applied successfully in commercial bioleaching heaps around the world, and microbial community and activity were adapted related to the local climatic conditions, ore characteristics and engineering configuration. This review focuses on diversity of bioleaching microbes, their role in heap bioleaching processes, their community structure and function in industrial heaps and the relation to the ore characteristics and the engineering configuration, to give implications for optimizing leaching efficiency of heap bioleaching. | Yan Jia Qiaoyi Tan Heyun Sun Yupeng Zhang Hongshan Gao Renman Ruan | 2019 | Green Energy & Environment2019，4，1： | 6 |
| 10 | Isolation and culture of hepatic stellate cells from mouse liver显示文摘肝的星形的房间(HSC ) 是在肝以内的主要细胞外的生产矩阵的房间并且有众多的 vitalfunctions。为 HSC 的隔离和文化的一个柔韧的协议是重要的因为房间 functionsand 的进一步的调查在肝疾病联系了机制。鼠标肝的卷比老鼠肝的小得多,哪个对更困难的 makesit 比老鼠 HSC 孤立鼠标 HSC (mHSCs ) 。目前,孤立 mHSCs 仍然是挑战 becausethere 不是有效、柔韧的方法孤立并且文化这些房间。在现在的学习, C57BL/6J 老鼠是有包含 liposome 的 dichloromethylene diphosphate (CL2MDP ) 的 intravenouslyinjected 有选择地从 theliver 消除 Kupffer 房间。老鼠肝然后在 situ 被酒,并且 mHSCs 与一种优化密度坡度 centrifugation 技术被孤立。在磷酸盐缓冲区答案(PBS )-liposome 组, mHSCs 的收益是(1. | Wenj u Chang Mengxuan Yang Lujun Song Kuntang Shen Hongshan Wang Xiaodong Gao Min Li Weixin Niu Xinyu Qin | 2014 | Acta Biochimica et Biophysica Sinica2014，46，4： | 6 |
| 11 | Instability characteristics of the East Asian Monsoon recorded by high-resolution loess sections from the last interglacial (MIS5)显示文摘The selection of high-resolution loess sections is needed in order to determine the climatic variability of the East Asian Monsoon during the last interglacial. Two sequences of S1 on the eastern and west-ern sides of the Liupan Mountain were both composed of five paleosol layers and four loess layers,indicating that there were five strong summer monsoon events and four strong winter monsoon events in MIS5. This corresponds with other records of the East Asian Monsoon,along with NGRIP and the North Atlantic records,implying that the climate of the Northern Hemisphere was very instable during the last interglacial. Two layers of paleosols and one layer of loess had developed during MIS5a and MIS5c. Compared with MIS5e,the climate in MIS5a and MIS5c fluctuated more intensively on a millen-nial scale,whereas the climate was relatively stable in MIS5e. | GUAN QingYu PAN BaoTian GAO HongShan LI BingYuan WANG JunPing SU Huai | 2007 | Science China Earth Sciences2007，50，7： | 5 |
| 12 | Autophagy enhanced by curcumin ameliorates inflammation in atherogenesis via the TFEB-P300-BRD4 axis显示文摘Disturbance of macrophage-associated lipid metabolism plays a key role in atherosclerosis.Crosstalk between autophagy deficiency and inflammation response in foam cells(FCs) through epigenetic regulation is still poorly understood. Here, we demonstrate that in macrophages, oxidized lowdensity lipoprotein(ox-LDL) leads to abnormal crosstalk between autophagy and inflammation,thereby causing aberrant lipid metabolism mediated through a dysfunctional transcription factor EB (TFEB)-P300-bromodomain-containing protein 4(BRD4) axis. ox-LDL led to macrophage autophagy deficiency along with TFEB cytoplasmic accumulation and increased reactive oxygen species generation. This activated P300 promoted BRD4 binding on the promoter regions of inflammatory genes, consequently contributing to inflammation with atherogenesis. Particularly, ox-LDL activated BRD4-dependent super-enhancer associated with liquid-liquid phase separation(LLPS) on the regulatory regions of inflammatory genes. Curcumin(Cur) prominently restored FCs autophagy by promoting TFEB nuclear translocation, optimizing lipid catabolism, and reducing inflammation. The consequences of P300 and BRD4 on super-enhancer formation and inflammatory response in FCs could be prevented by Cur. Furthermore, the anti-atherogenesis effect of Cur was inhibited by macrophage-specific Brd4 overexpression or Tfeb knock-out in Apoe knock-out mice via bone marrow transplantation. The findings identify a novel TFEB-P300-BRD4 axis and establish a new epigenetic paradigm by which Cur regulates autophagy, inhibits inflammation, and decreases lipid content. | Xuesong Li Ruigong Zhu Hong Jiang Quanwen Yin Jiaming Gu Jiajing Chen Xian Ji Xuan Wu Haiping Fu Hui Wang Xin Tang Yuanqing Gao Bingjian Wang Yong Ji Hongshan Chen | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 4 |
| 13 | Influence of secondary carbide precipitation and transformation on abrasion resistance of a 3Cr15Mo1V1.5 white iron显示文摘The relationship between the secondary carbide precipitation and transformation of the 3Cr15Mo1V1.5 white iron and abrasion resistance was investigated by using optical microscope (OM), transmission electron microscopy (TEM) and X-ray diffrac- tion (XRD). The results show that the properties of secondary carbides precipitated at holding stage play an important role in the abrasion resistance. After certain holding time at 833 K subcritical treatment, the grainy (Fe, Cr)23C6 carbide precipitated and the fresh martensite transformed at the holding stage for 3Cr15Mo1V1.5 white iron improve the bulk hardness and abrasion resistance of the alloy. Prolonging holding time, MoC and (Cr, V)2C precipitations cause the secondary hardening peak and the corresponding better abrasion resistance. Finally, granular (Fe, Cr)23C6 carbide in situ transforms into laminar M3C carbide and the matrix structure transforms into pearlitic matrix. These changes weaken hardness and abrasion resistance of the alloy sharply. | Haohuai Liu Jun Wang Baoluo Shen Hongshan Yang Shengji Gao Sijiu Huang | 2007 | Journal of University of Science and Technology Beijing2007，14，3： | 3 |
| 14 | Proliferation and differentiation potential of mouse adult hepatic progenitor cells cultured in vitro显示文摘,这研究试图孤立干细胞或祖先存在,从正常成年老鼠肝并且调查他们增长和区别的潜力。Hepatocytes 被修改二拍子的圆舞肝灌注方法和 centrifugation 孤立,然后在为观察的修改包含浆液的 DMEM 有教养超过 60 天。Immunofluorescence 技术被使用检查 hepatocytes 并且与白朊, -fetoprotein (法新社) 和 cytokeratin 检验殖民地的形成 19 (CK19 ) 。结果显示出为 hepatocyte 是强烈积极的那一些 hepatocytes 在文化的白天 1 上的特定的标记白朊,能在天被激活 23,由殖民地的快速的增长和形成列在后面。殖民地能不断地膨胀超过 60 天。在白天 5 上,在殖民地的所有房间表示了肝的干细胞(HSC ) 标记法新社。与文化的时间,在殖民地的一些房间失去了能力在天划分 1315,并且区分了进有大细胞质和大约二个原子核的房间,类似于成熟 hepatocytes 的外观词法上。这些区分的房间表明了白朊的强壮的表示。在白天 30 附近,一些大房间在殖民地出现了并且表示了胆汁管房间标记 CK19。因此,老鼠 hepatocytes 的这 subpopulation 能获得不成熟的 hepatocytes 的一些特征并且与区别的一个高增殖能力和双性人潜力显示出肝的祖先房间的侧面。他们从因此,成年人老鼠说出成年肝的祖先房间(AHPC ) 的正常被孤立。老鼠 AHPC 可以为 hepatocytes 移植和 hepatopathy 学习被用作一个 HSC 模型。 | Lujun Song Hongshan Wang Xiaodong Gao Kuntang Shen Weixin Niu Xinyu Qin | 2010 | Acta Biochimica et Biophysica Sinica2010，42，2： | 3 |
| 15 | Upregulation of GLT25D1 in Hepatic Stellate Cells Promotes Liver Fibrosis via the TGF-β1/SMAD3 Pathway In Vivo and In vitro显示文摘Background and Aims:Collagenβ(1-O)galactosyltransferase 25 domain 1(GLT25D1)is associated with collagen production and glycosylation,and its knockout in mice results in embryonic death.However,its role in liver fibrosis remains elusive,particularly in hepatic stellate cells(HSCs),the primary collagen-producing cells associated with liver fibrogenesis.Herein,we aimed to elucidate the role of GLT25D1 in HSCs.Methods:Bile duct ligation(BDL)-induced mouse liver fibrosis models,primary mouse HSCs(mHSCs),and transforming growth factor beta 1(TGF-β1)-stimulated LX-2 human hepatic stellate cells were used in in vivo and in vitro studies.Stable LX-2 cell lines with either GLT25D1 overexpression or knockdown were established using lentiviral transfection.RNA-seq was performed to investigate the genomic differences.HPLCMS/MS were used to identify glycosylation sites.Scanning electronic microscopy(SEM)and second-harmonic generation/two-photon excited fluorescence(SHG/TPEF)were used to image collagen fibril morphology.Results:GLT25D1 expression was upregulated in nonparenchymal cells in human cirrhotic liver tissues.Meanwhile,its knockdown attenuated collagen deposition in BDL-induced mouse liver fibrosis and inhibited mHSC activation.GLT25D1 was overexpressed in activated versus quiescence LX-2 cells and regulated in vitro LX-2 cell activation,including proliferation,contraction,and migration.GLT25D1 also significantly increased liver fibrogenic gene and protein expression.GLT25D1 upregulation promoted HSC activation and enhanced collagen expression through the TGF-β1/SMAD signaling pathway.Mass spectrometry showed that GLT25D1 regulated the glycosylation of collagen in HSCs,affecting the diameter of collagen fibers.Conclusions:Collectively,the upregulation of GLT25D1 in HSCs promoted the progression of liver fibrosis by affecting HSCs activation and collagen stability. | Shiwei Wang Lingling He Fan Xiao Meixin Gao Herui Wei Junru Yang Yang Shu Fuyang Zhang Xiaohui Ye Ping Li Xiaohua Hao Xingang Zhou Hongshan Wei | 2023 | Journal of Clinical and Translational Hepatology2023，11，1： | 1 |
| 16 | Non-canonical STING-PERK pathway dependent epigenetic regulation of vascular endothelial dysfunction via integrating IRF3 and NF-κB in inflammatory response显示文摘Inflammation-driven endothelial dysfunction is the major initiating factor in atherosclerosis,while the underlying mechanism remains elusive.Here,we report that the non-canonical stimulator of interferon genes(STING)-PKR-like ER kinase(PERK)pathway was significantly activated in both human and mice atherosclerotic arteries.Typically,STING activation leads to the activation of interferon regulatory factor 3(IRF3)and nuclear factor-kappa B(NF-κB)/p65,thereby facilitating IFN signals and infammation.In contrast,our study reveals the activated non-canonical STING-PERK pathway increases scaffold protein bromodomain protein 4(BRD4)expression,which encourages the formation of super-enhancers on the proximal promoter regions of the proinflammatory cytokines,thereby enabling the transactivation of these cytokines by integrating activated IRF3 and NF-κB via a condensation process.Endothelium-specific STING and BRD4 deficiency significantly decreased the plaque area and inflammation.Mechanistically,this pathway is triggered by leaked mitochondrial DNA(mtDNA)via mitochondrial permeability transition pore(mPTP),formed by voltage-dependent anion channel 1(VDAC1)oligomer interaction with oxidized mtDNA upon cholesterol oxidation stimulation.Especially,compared to macrophages,endothelial STING activation plays a more pronounced role in atherosclerosis.We propose a non-canonical STING-PERK pathway-dependent epigenetic paradigm in atherosclerosis that integrates IRF3,NF-κB and BRD4 in inflammatory responses,which provides emerging therapeutic modalities for vascular endothelial dysfunction. | Xuesong Li Xiang Chen Longbin Zheng Minghong Chen Yunjia Zhang Ruigong Zhu Jiajing Chen Jiaming Gu Quanwen Yin Hong Jiang Xuan Wu Xian Ji Xin Tang Mengdie Dong Qingguo Li Yuanqing Gao Hongshan Chen | 2023 | Acta Pharmaceutica Sinica B2023，13，12： | 1 |
| 17 | Dating of e- rosion surface and terraces in the Eastern Qilian Shan, Northwest China显示文摘 | Pan Baotian Gao Hongshan Wu Guangjian | 2007 | Earth SugCace Processes and Landforms2007，32，1： | 1 |
| 18 | Transplantation of bone marrow derived cells promotes pancreatic islet repair in diabetic mice显示文摘 | Xiaodong Gao Lujun Song Kuntang Shen Hongshan Wang Weixin Niu Xinyu Qin | 2008 | Biochemical and Biophysical Research Communications2008，，1： | 1 |
| 19 | High intratumoral expression of elF4A1 promotes epithelial-to-mesenchymal transition and predicts unfavorable prognosis in gastric cancer显示文摘Gastric cancer is an important health problem,being the fifth most common cancer and the third leading cause of cancer-related death worldwide.Aberrant protein translation contributes to the oncogenesis and development of cancers,and upregulation of translation initiation factor elF4A1 has been observed in several kinds of malignancies.However,the role of elF4A1 in gastric cancer progression remains unclear.In this study,we found that the expression of elF4A1,a component of translation initiation complex,was increased in gastric cancer.High expression of elF4A1 was positively associated with poor tumor differentiation,late T stage,lymph node metastasis,advanced TNM stage,and poor prognosis in patients with gastric cancer.Overexpression of elF4A1 promoted the migration and invasion of gastric cancer cells in vitro and enhanced tumor metastasis in nude mice model.Mechanism studies revealed that elF4A1 induced epithelial-to-mesenchymal transition(EMT)of gastric cancer cells through driving the translation of SNAI1 mRNA.Together,these findings indicate that elF4A1 promotes EMT and metastasis of gastric cancer and suggest that elF4A1 is a potential target for the adjuvant therapy for gastric cancer patients. | Chanchan Gao Xinyin Guo Anwei Xue Yuanyuan Ruan Hongshan Wang Xiaodong Gao | 2020 | Acta Biochimica et Biophysica Sinica2020，52，3： | 1 |
| 20 | Clamping effect driven design and fabrication of new infrared birefringent materials with large optical anisotropy显示文摘Infrared(IR)birefringent materials with large optical anisotropy and wide transparency range are important for efficient light manipulation in various IR optical devices.Herein,two new IR birefringent materials AMgGeSe_(3)(A=Li,Na)with large optical anisotropy were rationally designed by a rigid octahedron and flexible dimer combined strategy and fabricated in experiment.The introduction of rigid[LiSe_(6)]/[NaSe_(6)]and[MgSe_(6)]octahedra effectively regulates the geometry and arrangement of the flexible[Ge2Se6]dimers,resulting in the birefringence as large as 0.334@1,064 nm in LiMgGeSe_(3) and 0.445@1,064 nm(the largest one in the reported[Ge_(2)Se_(6)]dimer-contained selenides)in NaMgGeSe_(3).Density functional theory(DFT)calculations and statistical analyses highlight the influence of polarizability anisotropy,density,arrangement of units,as well as layer distance on birefringence.The results indicate that AMgGeSe_(3)(A=Li,Na)crystals are the promising IR birefringent materials and it gives an insight into the exploration of new IR birefringent materials with large birefringence based on the clamping effect from rigid groups. | Linan Wang Chenchen Tu Hongbo Gao Jiazheng Zhou Hongshan Wang Zhihua Yang Shilie Pan Junjie Li | 2023 | Science China Chemistry2023，66，4： | 0 |
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