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| 1 | Ablation of gut microbiota alleviates obesity-induced hepatic steatosis and glucose intolerance by modulating bile acid metabolism in hamsters显示文摘Since metabolic process differs between humans and mice, studies were performed in hamsters, which are generally considered to be a more appropriate animal model for studies of obesityrelated metabolic disorders. The modulation of gut microbiota, bile acids and the farnesoid X receptor(FXR) axis is correlated with obesity-induced insulin resistance and hepatic steatosis in mice. However,the interactions among the gut microbiota, bile acids and FXR in metabolic disorders remained largely unexplored in hamsters. In the current study, hamsters fed a 60% high-fat diet(HFD) were administeredvehicle or an antibiotic cocktail by gavage twice a week for four weeks. Antibiotic treatment alleviated HFD-induced glucose intolerance, hepatic steatosis and inflammation accompanied with decreased hepatic lipogenesis and elevated thermogenesis in subcutaneous white adipose tissue(sWAT). In the livers of antibiotic-treated hamsters, cytochrome P450 family 7 subfamily B member 1(CYP7 B1) in the alternative bile acid synthesis pathway was upregulated, contributing to a more hydrophilic bile acid profile with increased tauro-β-muricholic acid(TβMCA). The intestinal FXR signaling was suppressed but remained unchanged in the liver. This study is of potential translational significance in determining the role of gut microbiota-mediated bile acid metabolism in modulating diet-induced glucose intolerance and hepatic steatosis in the hamster. | Lulu Sun Yuanyuan Pang Xuemei Wang Qing Wu Huiying Liu Bo Liu George Liu Min Ye Wei Kong Changtao Jiang | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 29 |
| 2 | Flow visualization of silicon-based micro pulsating heat pipes显示文摘Two sets of silicon-based micro pulsating heat pipes(SMPHPs) with trapezoidal cross section having hydraulic diameters of 352 μm(#1) and 394 μm(#2) respectively were fabricated for the first time using MEMS technology.With FC-72 as the working fluid,the start-up,steady operation state,as well as flow patterns were investigated using a CCD camera.It was found that the start-up process of these two SMPHPs was rather rapid.At the start-up period,no nucleation was observed,and the vapor plugs at the evaporator U-bends were formed mainly due to the breakup of liquid slugs.At the steady operation state,self-sustained oscillation with large amplitudes dominated the flow behavior when the inclination angle varied from 10° to 90°,but the nucleate boiling and bulk circulation were observed only in SMPHP #2.While bubbly,slug/plug,annular/semi-annular,and wavy-annular flows were observed in both two SMPHPs,the injection flow only appeared in SMPHP #2. | QU Jian & WU HuiYing Key Laboratory for Power Machinery and Engineering of Ministry of Education,School of Mechanical Engineering,Shanghai Jiaotong University,Shanghai 200240,China | 2010 | Science China(Technological Sciences)2010，53，4： | 13 |
| 3 | Experimental investigation on color variation mechanisms of structural light in Papilio maackii ménétriès butterfly wings显示文摘The body color in animals results from billions of years of their natural evolution in order to evade natural enemies, catch quarries or display themselves beauty, in-vestigation on mechanisms of structural light is an important aspect of bionics. Based on the phenomenon of Papilio maackii ménétriès’ blue scales changing into green ones immediately after dropping some alcohol aqua on the underwing sur-face and soon returning back to the original color, the relationship between micro-structure, optics characteristic of scales and changing color effect were studied using the Olympus Stereomicroscope, Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM) and Ultraviolet (UV)-Visible Spectropho-tometer. The color variation mechanisms of blue scales of Papilio maackii mé-nétriès in Chinese Northeast were revealed in this paper. When visible lights trav-eled through the concaver structure with multilayer reflector and the filled medium with different refractive indices, the reflected lights in definite wavelengths pro-duced interference and color at that wavelength came into being. It has important academic reference value to biomimetics design of video stealth materials. | REN LuQuan QIU ZhaoMei HAN ZhiWu GUAN HuiYing WU LiYan | 2007 | Science China(Technological Sciences)2007，50，4： | 13 |
| 4 | Synthesis of ZnO nanorods and their optical absorption in visible-light region显示文摘单个水晶的 ZnO nanorods 被热水的方法与综合 ZnCl_2 · 4 Zn 准备(哦)_2 作为先锋。nanorods 的形态学被各种各样的反应条件作为修改代理人与 cetyltrimethylammonium 溴化物(CTAB ) 控制。Thenanorods 被 XRD, TEM,紫外力的系列,和红外系列描绘。在 nanosize 的洞的微观结构在 nanorods 的表面上被观察。紫外力的系列显示准备 theas 的 ZnO nanorods 有吸收可见光以及紫外光。因此,这些 nanorods 可以是从实际应用的观点的可见光的光催化材料的好候选人。为可见光的吸收的原因在这篇文章被讨论。 | WU Lili WU Youshi SHI Yuanchang WEI Huiying | 2006 | Rare Metals2006，25，1： | 5 |
| 5 | A Review on Artificial Micro/Nanomotors for Cancer-Targeted Delivery, Diagnosis, and Therapy显示文摘Micro/nanomotors have been extensively explored for efficient cancer diagnosis and therapy,as evidenced by significant breakthroughs in the design of micro/nanomotors-based intelligent and comprehensive biomedical platforms.Here,we demonstrate the recent advances of micro/nanomotors in the field of cancer-targeted delivery,diagnosis,and imaging-guided therapy,as well as the challenges and problems faced by micro/nanomotors in clinical applications.The outlook for the future development of micro/nanomotors toward clinical applications is also discussed.We hope to highlight these new advances in micro/nanomotors in the field of cancer diagnosis and therapy,with the ultimate goal of stimulating the successful exploration of intelligent micro/nanomotors for future clinical applications. | Jiajia Wang Renfeng Dong Huiying Wu Yuepeng Cai Biye Ren | 2020 | Nano-Micro Letters2020，12，1： | 5 |
| 6 | Depression accelerates gastric cancer invasion and metastasis by inducing a neuroendocrine phenotype via the catecholamine/β_(2)-AR/MACC1 axis显示文摘Background:Depression is a common,easily ignored,accompanied disease of gastric cancer(GC)patients and is often observed with elevated plasma catecholamine levels.Depression frequently promotes GC progression and leads to poor clinical outcomes;however,the molecular mechanisms underlying depression-induced GC progression remain poorly understood.We aimed to study the effects of depression on GC progression and explore possible mechanisms mediating the action of depression-associated catecholamines on GC.Methods:Depression states of GC patients were graded using the Patient Health Questionnaire-9,and plasma catecholamine levels were examined by high performance liquid chromatography coupled with tandem mass spectrometry.Migrative and invasive GC cells were examined using transwell assays,and metastatic GC niches were imaged using bioluminescence technology in a depression mouse model established with chronic unpredictable mild stress.Mouse depression-like behaviors were assessed through sucrose preference,forced swimming,and tail suspension tests.Characteristics of the neuroendocrine phenotype were observed via RT-PCR,Western blotting,flow cytometry,and transmission electron microscopy.Results:Fifty-one GC patients(age:53.61±1.79 years;cancer duration:3.71±0.33 months;depression duration:2.37±0.38 months;male-to-female ratio:1.55:1)were enrolled in the study.Depression grade was significantly higher in GC patients showing higher plasma levels of catecholamines(epinephrine:P=0.018;noradrenaline:P=0.009),higher oncogene metastasis-associated in colon cancer-1(MACC1)level(P=0.018),and metastasis(P<0.001).Further,depression-associated catecholamine specifically bound to the beta-2 adrenergic receptor(β_(2)-AR)and upregulated MACC1 expression,and thus promoting neuroendocrine phenotypic transformation through direct binding betweenMACC1 and synaptophysin.Eventually,the neuroendocrine phenotypic transformation accelerated GC invasion in vitro and metastasis in vivo.However,β_(2)-AR antagonist ICI-118,551 or MACC1 silencing effectively blocked the catecholamineinduced neuroendocrine phenotypic transformation and eliminated depressionenhanced GC migration and invasion.Moreover,β_(2)-AR blocking or MACC1 silencing prevented GC metastasis attributed to a neuroendocrine phenotype in a depression mouse model.Conclusions:Catecholamine-induced neuroendocrine phenotypes of GC cells led to depression-accelerated GC invasion and metastasis via the β_(2)-AR/MACC1 axis,while β_(2)-AR antagonist or MACC1 silencing could reverse it,showing promising potential therapeutic strategies for improving the outcome of GC patients with comorbid depression. | Changqie Pan Jianhua Wu Siting Zheng Huiying Sun Yisheng Fang Zhenhua Huang Min Shi Li Liang Jianping Bin Yulin Liao Jinzhang Chen Wangjun Liao | 2021 | Cancer Communications2021，41，10： | 4 |
| 7 | Development of an antimicrobial peptide-loaded mineralized collagen bone scaffold for infective bone defect repair显示文摘The repair of infective bone defects is a great challenge in clinical work.It is of vital importance to develop a kind of bone scaffold with good osteogenic properties and long-term antibacterial activity for local anti-infection and bone regeneration.A porous mineralized collagen(MC)scaffold containing poly(D,L-lactide-co-glycolic acid)(PLGA)microspheres loaded with two antibacterial synthetic peptides,Pac-525 or KSL-W was developed and characterized via scanning electron microscopy(SEM),porosity measurement,swelling and mechanical tests.The results showed that the MC scaffold embedded with smooth and compact PLGA microspheres had a positive effect on cell growth and also had antibacterial properties.Through toxicity analysis,cell morphology and proliferation analysis and alkaline phosphatase evaluation,the antibacterial scaffolds showed excellent biocompatibility and osteogenic activity.The antibacterial property evaluated with Staphylococcus aureus and Escherichia coli suggested that the sustained release of Pac-525 or KSL-W from the scaffolds could inhibit the bacterial growth aforementioned in the long term.Our results suggest that the antimicrobial peptides-loaded MC bone scaffold has good antibacterial and osteogenic activities,thus providing a great promise for the treatment of infective bone defects. | Yuzhu He Yahui Jin Xiaoxia Ying Qiong Wu Shenglian Yao Yuanyuan Li Huiying Liu Guowu Ma Xiumei Wang | 2020 | Regenerative Biomaterials2020，7，5： | 3 |
| 8 | A super pan-genomic landscape of rice显示文摘Pan-genomes from large natural populations can capture genetic diversity and reveal genomic complexity.Using de novo longread assembly,we generated a graph-based super pan-genome of rice consisting of a 251-accession panel comprising both cultivated and wild species of Asian and African rice.Our pan-genome reveals extensive structural variations(SVs)and gene presence/absence variations.Additionally,our pan-genome enables the accurate identification of nucleotide-binding leucine-rich repeat genes and characterization of their inter-and intraspecific diversity.Moreover,we uncovered grain weight-associated SVs which specify traits by affecting the expression of their nearby genes.We characterized genetic variants associated with submergence tolerance,seed shattering and plant architecture and found independent selection for a common set of genes that drove adaptation and domestication in Asian and African rice.This super pan-genome facilitates pinpointing of lineage-specific haplotypes for trait-associated genes and provides insights into the evolutionary events that have shaped the genomic architecture of various rice species. | Lianguang Shang Xiaoxia Li Huiying He Qiaoling Yuan Yanni Song Zhaoran Wei Hai Lin Min Hu Fengli Zhao Chao Zhang Yuhua Li Hongsheng Gao Tianyi Wang Xiangpei Liu Hong Zhang Ya Zhang Shuaimin Cao Xiaoman Yu Bintao Zhang Yong Zhang Yiqing Tan Mao Qin Cheng Ai Yingxue Yang Bin Zhang Zhiqiang Hu Hongru Wang Yang Lv Yuexing Wang Jie Ma Quan Wang Hongwei Lu Zhe Wu Shanlin Liu Zongyi Sun Hongliang Zhang Longbiao Guo Zichao Li Yongfeng Zhou Jiayang Li Zuofeng Zhu Guosheng Xiong Jue Ruan Qian Qian | 2022 | Cell Research2022，32，10： | 3 |
| 9 | Enhanced Heat Transfer of Carbon Nanotube Nanofluid Microchannels Applied on Cooling Gallium Arsenide Cell显示文摘Carbon nanotube nanofluids have wide application prospects due to their unique structure and excellent properties.In this study,the thermal conductivity properties of carbon nanotube nanofluids and SiO2/water nanofluids were compared and analyzed experimentally using different preparation methods.The physical properties of nanofluids were tested using a Malvern Zetasizer Nano Instrument and a Hot Disk Thermal Constant Analyzer.Combined with field synergy theory analysis of the heat transfer performance of nanofluids,results show that the thermal conductivity of carbon nanotube nanofluids is higher than that of SiO2/water nanofluids,and the thermal conductivity of nanofluid rises with the increase of mass fraction and temperature.Moreover,the synergistic performance of carbon nanotube nanofluids is also superior to that of SiO2/water nanofluids.When the mass fraction of the carbon nanotube nanofluids is 10%and the SiO2/water nanofluids is 8%,their field synergy numbers and heat transfer enhancement factors both reach maximum.From the perspective of the preparation method,the thermal conductivity of nanofluids dispersed by high shear microfluidizer is higher than that by ultrasonic dispersion.This result provides some reference for the selection and use of working substance in a microchannel cooling concentrated photovoltaic and thermal(CPV/T)system. | ZHANG Huiying YAN Suying WANG Tao WU Yuting ZHAO Xiaoyan ZHAO Ning | 2020 | Journal of Thermal Science2020，29，6： | 3 |
| 10 | Generation of purple-violet chrysanthemums via anthocyanin B-ring hydroxylation and glucosylation introduced from Osteospermum hybrid F3'5'H and Clitoria ternatea A3'5'GT显示文摘Chrysanthemums possess no metabolic pathway to synthesize delphinidin because of the lack of endogenous F3'5'H gene encoding the key enzyme in its biosynthetic pathway;therefore,there are no blue or blue-purple chrysanthemums occurring naturally.Currently,the introduction of exogenous F3'5'H into chrysanthemums is an efficient method for breeding bluish chrysanthemums.In this study,we explored the effects of the introduction of mutant CmF3'H(generated via site-directed mutagenesis,T485S,CmF3'Hm)and exogenous Osteospermum hybrid F3'5'H(OhF3'5'H)genes combined with Clitoria ternatea A3'5'GT(CtA3'5'GT)on delphinidin synthesis in chrysanthemum.Among the F3'5'H transgenic lines,those overexpressing endogenous CmF3'Hm could not generate blue flower color,although red color was changed to light pink due to CtA3'5'GT function.Meanwhile,OhF3'5'H introduction promoted the accumulation of delphinidin and its derivatives in chrysanthemum,changing the flower color from red-purple to purple-violet.These results indicate the applicability of exogenous OhF3'5'H and CtA3'5'GT transformation for promoting delphinidin synthesis during the molecular breeding of violet/blue chrysanthemums. | Xiaoying Han Yuting Luo Jiaoyang Lin Huiying Wu Hao Sun Lijie Zhou Sumei Chen Zhiyong Guan Weimin Fang Fei Zhang Fadi Chen Jiafu Jiang | 2021 | Ornamental Plant Research2021，1，1： | 3 |
| 11 | SOLIDIFICATION MICROSTRUCTURE OF Ni-BASE SUPERALLOY POWDER显示文摘The solidification microstructure and phase composition of Ni-base superalloy FGH95 pow-der with different mesh size have been investigated.The structure transition was found fromdendrite in major into cellular structure as the powder size reduces and the cooling rate in-creases.The predominant phase was identified as MC-type carbide,with differentmorphologies,which may be related to their composition and the condition ofsolidification.Minor phases,such as boride,Laves and primary γ’ are also present as ac-companiments of the carbide. | HU Benfu LI Huiying WU Chengjian ZHANG Shouhua University of Science and Technology Beijing,Beijing,China Associate Professor,Dept.of Material Science and Engineering,University of Science and technology Beijing,Beijing 100083,China. | 1991 | Acta Metallurgica Sinica(English Letters)1991，4，2： | 2 |
| 12 | Transcriptomic Response to Yersinia pestis:RIG-I Like Receptor Signaling Response Is Detrimental to the Host against Plague显示文摘Bacterial pathogens have evolved various mechanisms to modulate host immune responses for successful infection.In this study,RNAsequencing technology was used to analyze the responses of human monocytes THP1 to Yersinia pestis infection.Over 6000 genes were differentially expressed over the 12 h infection.Kinetic responses of pathogen recognition receptor signaling pathways,apoptosis,antigen processing,and presentation pathway and coagulation system were analyzed in detail.Among them,RIG-I-like receptor(RLR) signaling pathway,which was established for antiviral defense,was significantly affected.Mice lacking MAVS,the adaptor of the RLR signahng pathway,were less sensitive to infection and exhibited lower IFN-P production,higher Thl-type cytokines IFN-y and IL-12 production,and lower Th2-type cytokines EL-4 and IL-13 production in the serum compared with wild-type mice.Moreover,infection of pathogenic bacteria other than Y.pestis also altered the expression of the RLR pathway,suggesting that the response of RLR pathway to bacterial infection is a universal mechanism. | Zongmin Du Huiying Yang Yafang Tan Guang Tian Qingwen Zhang Yujun Cui Yanfeng Yan Xiaohong Wu Zuyun Chen Shiyang Cao Yujing Bi Yanping Han Xiaoyi Wang Yajun Song Ruifu Yan | 2014 | Journal of Genetics and Genomics2014，41，7： | 2 |
| 13 | Epidemiological Survey and Analysis on an Outbreak of Gastroenteritis due to Water Contamination显示文摘Objective To document the investigation and control of an outbreak of gastroenteritis in City G,South China,and provide a reference for preventing future outbreaks.Methods An ambispective cohort study was designed.Attack rate (AR) and relative risks (RR) were calculated to identify the causes of gastroenteritis.Investigations using questionnaires included personal interviews with patients and doctors,reviews of medical records,laboratory examinations of fecal specimens and continuous hygiene monitoring of water samples from the waterworks.Results Overall,427/71534 (AR=5.97‰) cases were identified between October 31 and November 12 2010.Geographic distribution was highly localized,with 80% of cases occurring in the areas supplied by waterworks‐A.Consumption of water provided solely by waterworks‐A was found to be associated with illness (RR=8.20,95 CI%:6.12-10.99) compared with that from waterworks‐B.Microbiological analyses confirmed the presence of Norovirus in six of eight fecal samples from symptomatic patients,two water samples from waterworks‐A and two sewage samples.After taking effective measures,the hygienic indices of waterworks‐A met health criteria again on November 9 and no cases were reported 3 days later.Conclusion The outbreak reported here was caused by drinking tap water contaminated with sewage at the source.Early identification of possible contamination sources and awareness of changes that might negatively impact water quality are important preventive measures to protect public health. | YANG ZhlCong WU XinWei LI TieGang LI MeiXia ZHONG Yi LIU YuFei DENG ZhiAi DI Biao HUANG Cong LIANG HuiYing WANG Ming | 2011 | Biomedical and Environmental Sciences2011，24，3： | 2 |
| 14 | Steam Oxidation Resistance of Silicon Carbide Castables at Elevated Temperatures显示文摘Silicon carbide castables of different SiC contents(86%and 71%,by mass)were prepared using white fused corundum,silicon carbide particles and fines,activated alumina powder,silica fume and pure calcium aluminate cement as main starting materials,heat treating at 1000℃ for 3 h,and oxidizing in steam atmosphere at 1000℃ for different durations(100,200,300,400 and 500 h).The mass and volume before and after oxidation,the bulk density,the apparent porosity and the cold compressive strength were tested.The phase composition and the microstructure before and after oxidation were analyzed by XRD and SEM.The results indicate that:(1)within 300 h of oxidation duration,silicon carbide shows an increasing oxidation rate;however,the oxidation rate is low during 300-500 h of oxidation duration;2)the oxidation rate of the specimen with 71%SiC is slightly higher than the one with 86%SiC;3)with the increasing oxidation degree of silicon carbide,the apparent porosity of the specimens tends to increase,followed by the declining bulk density and cold compressive strength. | SHI Huiying WANG Jiaping WU Jiguang HUANG Zhigang QIN Hongbin | 2021 | China's Refractories2021，30，3： | 2 |
| 15 | Dual effects of slightly acidic electrolyzed water (SAEW) treatment on the accumulation of -Aminobutyric acid (GABA) and rutin in germinated buckwheat 显示文摘 | Jiangxiong Hao Tongiiao Wu Huiying Li | 2016 | Food Chemistry2016，，15： | 1 |
| 16 | Analyzing Electricity Consumption via Data Mining显示文摘This paper proposes a model to analyze the massive data of electricity.Feature subset is determined by the correla-tion-based feature selection and the data-driven methods.The attribute season can be classified successfully through five classi-fiers using the selected feature subset,and the best model can be determined further.The effects on analyzing electricity consump-tion of the other three attributes,including months,businesses,and meters,can be estimated using the chosen model.The data used for the project is provided by Beijing Power Supply Bureau.We use WEKA as the machine learning tool.The models we built are promising for electricity scheduling and power theft detection. | LIU Jinshuo LAN Huiying FU Yizhen WU Hui LI Peng | 2012 | Wuhan University Journal of Natural Sciences2012，17，2： | 1 |
| 17 | Thermal Perfor- mance of an Oscillating Heat Pipe With A12Oa Water Nanofluids 显示文摘 | QU Jian WU Huiying CHENG Ping | 2010 | International Communications in Heat and Mass Transfer2010，37，11： | 1 |
| 18 | Preparation and photocatalysis of TiO2 nanoparticles Co-doped with nitrogen and lanthanum显示文摘 | Wei Huiying Wu Youshi Lun Ning | 2004 | J Mater Sei2004，39，4： | 1 |
| 19 | Boiling instability in parallel silicon microchannels at different heat flux显示文摘 | Wu Huiying Cheng Pin | 2004 | International Journal of Heat and Mass Transfer2004，47，： | 1 |
| 20 | Synthesis and characteristics of NiO nanowire by a solution method 显示文摘 | Wu Lili Wu Youshi Wei Huiying | 2004 | Materials Letters2004，58，： | 1 |
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