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| 1 | Cancer burden in China:trends,risk factors and prevention显示文摘As the most populous country in the world,China has made strides in health promotion in the past few decades.With the aging population,the burden of cancer in China continues to grow.Changes in risk factors for cancer,especially diet,obesity,diabetes,and air pollution,continue to fuel the shift of cancer transition in China.The burden of upper gastrointestinal cancer in China is decreasing,but still heavy.The rising burden of colorectal,prostate,and breast cancers is also significant.Lung cancer became the top cause of cancer-related deaths,together with smoking as the most important contributor to cancer deaths.The Chinese government has taken several approaches to control cancer and cancer-related risk factors.Many achievements have been made,but some challenges remain.Health China 2030 is ambitious and depicts a bright vision of the future for cancer control in China.The decrease in the cancer burden in China will require cross-sector collaboration and coordinated efforts on primary and secondary preventions by governments,public health organizations,and individuals.In this review,we describe the trends of cancer burden and discuss cancer-related risk factors in China,identifying strategies to reduce the burden of cancer in China. | Dianqin Sun He Li Maomao Cao Siyi He Lin Lei Ji Peng Wanqing Chen | 2020 | Cancer Biology & Medicine2020，17，4： | 62 |
| 2 | Long-term efficacy of perioperative chemoradiotherapy on esophageal squamous cell carcinoma显示文摘AIM: To investigate the role of perioperative chemoradiotherapy (CRT) in the treatment of locally advanced thoracic esophageal squamous cell carcinoma (ESCC). METHODS: Using preoperative computed tomography (CT)-based staging criteria, 238 patients with ESCC (stage ⅡⅢ ) were enrolled in this prospective study between January 1997 and June 2004. With informed consent, patients were randomized into 3 groups: preoperative CRT (80 cases), postoperative CRT (78 cases) and surgery alone (S) (80 cases). The 1-, 3-, 5and 10-year survival were followed up. Progressionfree survival (PFS) was chosen as the primary endpoint by treatment arm measured from study entry until documented progression of disease or death from any cause. The secondary endpoint was overall survival (OS) determined as the time (in months) between the date of therapy and the date of death. Other objectives were surgical and adjuvant therapy complications.RESULTS: With median follow-up of 45 mo for all the enrolled patients, significant differences in the 1-, 3-, 5-, 10-year OS (91.3%, 63.5%, 43.5%, 24.5% vs 91%, 62.8%, 42.3%, 24.4% vs 87.5%, 51.3%, 33.8%, 12.5%, P = 0.0176) and PFS (89.3%, 61.3%, 37.5%, 18.1% vs 89.1%, 61.1%, 37.2%, 17.8% vs 84.5%, 49.3%, 25.9%, 6.2%, P = 0.0151) were detected among the 3 arms. There were no significant differences in OS and PFS between the preoperative CRT and postoperative CRT arm (P > 0.05). For the patients who had radical resection, significant differences in median PFS (48 mo vs 61 mo vs 39.5 mo, P = 0.0331) and median OS (56.5 mo vs 72 mo vs 41.5 mo, P = 0.0153) were detected among the 3 arms, but there were no significant differences in OS and PFS between the preoperative CRT and postoperative CRT arm (P > 0.05). The local recurrence rates in the preoperative CRT, postoperative CRT group and S group were 11.3%, 14.1% and 35%, respectively (P < 0.05). No significant differences were detected among the 3 groups when comparing complications but tended to be in favor of the postoperative CRT and S groups (P > 0.05). Toxicities of CRT in the preoperative or postoperative CRT arms were mostly moderate, and could be quickly alleviated by adequate therapy. CONCLUSION: Rational application of preoperative or postoperative CRT can provide a benefit in PFS and OS in patients with locally advanced ESCC. | Lv, Jin Cao, Xiu-Feng Zhu, Bin Ji, Lv Tao, Lei Wang, Dong-Dong | 2010 | World Journal of Gastroenterology2010，16，13： | 49 |
| 3 | Mitochondrial PKM2 regulates oxidative stress-induced apoptosis by stabilizing Bcl2显示文摘 | Ji Liang Ruixiu Cao Xiongjun Wang Yajuan Zhang Pan Wang Hong Gao Chen Li Fan Yang Rong Zeng Ping Wei Dawei Li Wenfeng Li Weiwei Yang | 2017 | Cell Research2017，27，3： | 39 |
| 4 | Current cancer burden in China: epidemiology, etiology, and prevention显示文摘Cancer has become the most common cause of death in China.Owing to rapid economic development,improved livelihood,and shifts in risk factors,cancer epidemiology has experienced substantial changes during the past several decades.In this review,we aim to describe the current cancer epidemiology of the main types of cancer in China,report major risk factors associated with cancer development,and summarize the contributions of the Chinese government to controlling the cancer burden.A total of 4,064,000 new cases were diagnosed in China in 2016.The most frequent types are lung cancer(828,100;20.4%),colorectal cancer(408,000;10.0%),and gastric cancer(396,500;9.8%).Lung(657,000;27.2%),liver(336,400,13.9%),and stomach(288,500;12.0%)cancers are the 3 most deadly cancers in the general population.The 5-year survival rate for cancer has dramatically increased in recent decades.However,liver and particularly pancreatic cancers still have the poorest prognosis.The main modifiable risk factors associated with cancer development include infectious agents,smoking,alcohol consumption,obesity,unhealthful dietary habits,and inadequate physical activity.The Chinese government has made unremitting efforts to decrease the cancer burden,including cancer education and investment in cancer screening programs. | Maomao Cao He Li Dianqin Sun Siyi He Xinxin Yan Fan Yang Shaoli Zhang Changfa Xia Lin Lei Ji Peng Wanqing Chen | 2022 | Cancer Biology & Medicine2022，19，8： | 33 |
| 5 | Effect of neoadjuvant chemoradiotherapy on prognosis and surgery for esophageal carcinoma显示文摘AIM:To investigate the role of neoadjuvant chemoradiotherapy in prognosis and surgery for esophageal carcinoma by a meta-analysis.METHODS:PubMed and manual searches were done to identify all published randomized controlled trials(RCTs) that compared neoadjuvant chemoradiotherapy plus surgery(CRTS) with surgery alone(S) for esophageal cancer.According to the test of heterogeneity,a fi xed-effect model or a random effect model was used and the odds ratio(OR) was the principal measure of effects.RESULTS:Fourteen RCTs that included 1737 patients were selected with quality assessment ranging from A to C(Cochrane Reviewers' Handbook 4.2.2).OR(95% CI,P value),expressed as CRTS vs S(values>1 favor CRTS arm),was 1.19(0.94-1.48,P=0.28) for 1-year survival,1.33(1.07-1.65,P=0.69) for 2-year survival,1.76(1.42-2.19,P=0.11) for 3-year survival,1.41(1.06-1.87,P=0.11) for 4-year survival,1.64(1.28-2.12,P=0.40) for 5-year survival,0.82(0.39-1.73,P<0.0001) for rate of resection,1.53(1.33-2.84,P=0.007) for rate of complete resection,1.78(1.14-2.78,P=0.79) for operative mortality,1.12(0.89-2.48,P=0.503) for all treatment mortality,1.33(0.94-1.88,P=0.04) for the rate of adverse treatment,1.38(1.23-1.63,P=0.0002) for local-regional cancer recurrence,1.28(0.85-1.58,P=0.60) for distant cancer recurrence,and 1.27(0.86-1.65,P=0.19) for all cancer recurrence.A complete pathological response to chemoradiotherapy occurred in 10%-45.5% of patients.The 5-year survival benefi t was most pronounced when chemotherapy and radiotherapy were given concurrently(OR:1.45,95% CI:1.26-1.79,P=0.015) instead of sequentially(OR:0.85,95% CI:0.64-1.35,P=0.26).CONCLUSION:Compared with surgery alone,neoadjuvant chemoradiotherapy can improve the long-term survival and reduce local-regional cancer recurrence.Concurrent administration of neoadjuvant chemoradiotherapy was superior to sequential chemoradiotherapy. | Jin Lv Xiu-Feng Cao Bin Zhu Lv Ji Lei Tao Dong-Dong Wang | 2009 | World Journal of Gastroenterology2009，15，39： | 27 |
| 6 | Virus-related liver cirrhosis: Molecular basis and therapeutic options显示文摘Chronic infections with hepatitis B virus(HBV)and/or hepatitis C virus(HCV)are the major causes of cirrhosis globally.It takes 10-20 years to progress from viral hepatitis to cirrhosis.Intermediately active hepatic inflammation caused by the infections contributes to the inflammation-necrosis-regeneration process,ultimately cirrhosis.CD8+T cells and NK cells cause liver damage via targeting the infected hepatocytes directly and releasing pro-inflammatory cytokine/chemokines.Hepatic stellate cells play an active role in fibrogenesis via secreting fibrosis-related factors.Under the inflammatory microenvironment,the viruses experience mutationselection-adaptation to evade immune clearance.However,immune selection of some HBV mutations in the evolution towards cirrhosis seems different from that towards hepatocellular carcinoma.As viral replication is an important driving force of cirrhosis pathogenesis,antiviral treatment with nucleos(t)ide analogs is generally effective in halting the progression of cirrhosis,improving liver function and reducing the morbidity of decompensated cirrhosis caused by chronic HBV infection.Interferon-αplus ribavirin and/or the direct acting antivirals such as Vaniprevir are effective for compensatedcirrhosis caused by chronic HCV infection.The standard of care for the treatment of HCV-related cirrhosis with interferon-αplus ribavirin should consider the genotypes of IL-28B.Understanding the mechanism of fibrogenesis and hepatocyte regeneration will facilitate the development of novel therapies for decompensated cirrhosis. | Ji Lin Jian-Feng Wu Qi Zhang Hong-Wei Zhang Guang-Wen Cao | 2014 | World Journal of Gastroenterology2014，20，21： | 24 |
| 7 | Small molecule inhibitors targeting the PD-1/PD-L1 signaling pathway显示文摘Tumor cells form immune escape and subsequently obtain unlimited proliferation ability due to the abnormal immune surveillance mediated by immune checkpoints.Among this class of immune checkpoints,PD-1/PD-L1 was recognized as an anticancer drug target for many years,and so far,several monoclonal antibodies have achieved encouraging outcome in cancer treatment by targeting the PD-1/PD-L1 signaling pathway.Due to the inherent limitations of antibodies,the development of small molecule inhibitors based on PD-1/PD-L1 signaling pathway is gradually reviving in decades.In this review,we summarized a number of small molecule inhibitors based on three different therapeutic approaches interfering PD-1/PD-L1 signaling pathway:(1)blocking direct interaction between PD-1 and PD-L1;(2)inhibiting transcription and translation of PD-L1;and(3)promoting degradation of PD-L1 protein.The development of these small molecule inhibitors opens a new avenue for tumor immunotherapy based on PD-1/PD-L1 signaling pathway. | Qian Wu Li Jiang Si-cheng Li Qiao-jun He Bo Yang Ji Cao | 2021 | Acta Pharmacologica Sinica2021，42，1： | 22 |
| 8 | Novel neuroprotectant chiral 3-n-butylphthalide inhibits tandem-pore-domain potassium channel TREK-1显示文摘 | Xin-cai JI Wan-hong ZHAO Dong-xu CAO Qiao-qiao SHI Xiao-liang WANG | 2011 | Acta Pharmacologica Sinica2011，32，2： | 20 |
| 9 | Congenital choledochal cysts in adults:twenty-five-year experience显示文摘背景 Choledochal 包囊在西方的国家是稀罕的。共存的 hepatobiliary 疾病的相对高的发生增加 choledochal 包囊的外科的管理的困难。这里,我们在有先天的 choledochal 包囊的 122 个病人的临床的数据从 1981 ~ 2006 承认了的 122 中国 adults.Methods 分析先天的胆汁管包囊的诊断和治疗,导致推迟的诊断是在大多数情况中的临床的症状是的 analyzed.Results nonspecific。61 个病人(50%) 有共存的 pancreatobiliary 疾病。在 122 个病人之中, 119 个病人经历了超声的检查; ERCP/MRCP 在 102 种情况中在 63 种情况和 CT 中被执行。反常 pancreatobiliary 管连接在 48 个病人被发现。十六个病人在胆汁管有恶意的损害,从经历了包括 cystenterostomy 或 cystojejunostomy 的各种各样的操作的不完全的 choledochal 包囊在他们中的 11 个产生。处于胆汁管的恶意率经历了不完全的包囊切除术和完全的包囊切除术的病人之间有重要差别(迟平方测试, P= 0.000;机会比率, 7.800;95 % 信心间隔, 2.450 ~ 24.836 ).Conclusions ERCP, CT 和 MRCP 在疾病的分类证明了他们的大价值。有 Roux-en-Y hepaticojejunostomy 的包囊切除与类型或类型包囊为病人被推荐为选择的治疗。为有周期性的胆管炎的类型包囊(Caroli 的疾病) ,肝移植应该被考虑。 | LIU Ying-bin WANG Jian-wei Khagendra Raj Devkota JI Zhen-ling LI Jiang-tao WANG Xu-an MA Xiao-ming CAI Wei-long KONG Ying CAO Li-ping PENG Shu-you | 2007 | Chinese Medical Journal2007，，16： | 19 |
| 10 | Effect of domperidone therapy on nocturnal dyspeptic symptoms of functional dyspepsia patients显示文摘AIM:To investigate the incidence of nocturnal dyspeptic symptoms in patients with functional dyspepsia(FD) and whether prokinetic drugs can alleviate them. METHODS:Eighty-five consecutive Chinese patients with FD were included in this study.One week after single-blinded placebo run-in treatment,baseline nocturnal intragastric pH,bile reflux and nocturnal dyspeptic symptoms of eligible patients,including epigastric pain or discomfort,abdominal distention and belching, were investigated with questionnaires.Patients exhibiting nocturnal dyspeptic symptoms were randomly and double-blindly assigned to domperidone group or placebo group.Nocturnal intragastric pH and percentage of duodenogastric bile reflux time were determined after treatment. RESULTS:Of the 85 FD patients,2 females withoutnocturnal symptoms,who responded to placebo run-in treatment,were excluded from the study,30(36.1%) exhibited nocturnal dyspeptic symptoms with increased duodenogastric bile reflux time(intragastric bilirubin absorbance>0.14)and mean gastric pH(confirming the existence of bile reflux)(P=0.021,0.023) at night were included in the study.Of these 30 patients,21(70%)had overt nocturnal duodenogastric bile reflux,which was significantly higher than that of those without nocturnal symptoms(P=0.026).The 30 patients were allocated to domperidone group or placebo group(n=15).The nocturnal duodenogastric bile reflux and gastric pH were significantly decreased after domperidone treatment(P=0.015,0.021).The severity score of nocturnal dyspeptic symptoms was also significantly decreased after domperidone treatment (P=0.010,0.015,0.026),which was positively correlated with the reduced nocturnal bile reflux or gastric pH(r=0.736,0.784,0.753 or r=0.679,0.715,0.697, P=0.039,0.036,0.037 or P=0.043,0.039,0.040). CONCLUSION:A subgroup of Chinese FD patients show overt nocturnal dyspeptic symptoms,which may be correlated with the excessive nocturnal duodenogastric bile reflux.Domperidone therapy can alleviate these symptoms. | Chen, Sheng-Liang Ji, Jie-Ru Xu, Ping Cao, Zhi-Jun Mo, Jian-Zhong Fang, Jing-Yuan Xiao, Shu-Dong | 2010 | World Journal of Gastroenterology2010，16，5： | 18 |
| 11 | Reversing drug resistance of soft tumor-repopulating cells by tumor cell-derived chemotherapeutic microparticles显示文摘颠倒使人重新住入肿瘤的房间(TRC ) 的药抵抗或起源的发展中的新奇途径像房间的癌症房间是迫切临床的需要改进癌症病人的结果。这里,我们显示出用肿瘤颠倒 TRC 的药抵抗的一条创新途径包含反肿瘤药的导出房间的 microparticles (T-MPs ) 。由比区分的癌症房间更可变形的优点, TRC 优先地收起 T-MPs 在进入房间以后释放反肿瘤药,它接着导致 TRC 的死亡。内在的机制包括防碍药流出并且支持这些药的原子入口。我们的调查结果在用有希望的临床的应用程序颠倒 TRC 的药抵抗在 T-MPs 的举起和一条新奇途径的有效性表明肿瘤房间柔软的重要性。 | Jingwei Ma Yi Zhang Ke Tang Huafeng Zhang Xiaonan Yin Yong Li Pingwei Xu Yanling Sun Ruihua Ma Tiantian Ji Junwei Chen Shuang Zhang Tianzhen Zhang Shunqun Luo Yang Jin Xiuli Luo Chengyin Li Hongwei Gong Zhixiong Long Jinzhi Lu Zhuowei Hu Xuetao Cao Ning Wang Xiangliang Yang Bo Huang | 2016 | Cell Research2016，26，6： | 17 |
| 12 | Advanced Space-based Solar Observatory(ASO-S):an overview显示文摘The Advanced Space-based Solar Observatory(ASO-S)is a mission proposed for the 25 th solar maximum by the Chinese solar community.The scientific objectives are to study the relationships between the solar magnetic field,solar flares and coronal mass ejections(CMEs).Three payloads are deployed:the Full-disk vector Magneto Graph(FMG),the Lyman-αSolar Telescope(LST)and the Hard X-ray Imager(HXI).ASO-S will perform the first simultaneous observations of the photospheric vector magnetic field,non-thermal imaging of solar flares,and the initiation and early propagation of CMEs on a single platform.ASO-S is scheduled to be launched into a 720 km Sun-synchronous orbit in 2022.This paper presents an overview of the mission till the end of Phase-B and the beginning of Phase-C. | Wei-Qun Gan Cheng Zhu Yuan-Yong Deng Hui Li Yang Su Hai-Ying Zhang Bo Chen Zhe Zhang Jian Wu Lei Deng Yu Huang Jian-Feng Yang Ji-Jun Cui Jin Chang Chi Wang Ji Wu Zeng-Shan Yin Wen Chen Cheng Fang Yi-Hua Yan Jun Lin Wei-Ming Xiong Bin Chen Hai-Chao Bao Cai-Xia Cao Yan-Ping Bai Tao Wang Bing-Long Chen Xin-Yu Li Ye Zhang Li Feng Jiang-Tao Su Ying Li Wei Chen You-Ping Li Ying-Na Su Hai-Yan Wu Mei Gu Lei Huang Xue-Jun Tang | 2019 | Research in Astronomy and Astrophysics2019，19，11： | 17 |
| 13 | COVID-19 Outbreak Caused by Contaminated Packaging of Imported Cold-Chain Products—Liaoning Province,China,July 2020显示文摘Summary What is known about this topic?Few major outbreaks of coronavirus disease 2019(COVID-19)have occurred in China after major nonpharmaceutical interventions and vaccines have been deployed and implemented.However,sporadic outbreaks that had high possibility to be linked to cold chain products were reported in several cities of China..What is added by this report?In July 2020,a COVID-19 outbreak occurred in Dalian,China.The investigations of this outbreak strongly suggested that the infection source was from COVID-19 virus-contaminated packaging of frozen seafood during inbound unloading personnel contact.What are the implications for public health practice?Virus contaminated paper surfaces could maintain infectivity for at least 17–24 days at-25℃.Exposure to COVID-19 virus-contaminated surfaces is a potential route for introducing the virus to a susceptible population.Countries with no domestic transmission of COVID-19 should consider introducing prevention strategies for both inbound travellers and imported goods.Several measures to prevent the introduction of the virus via cold-chain goods can be implemented. | Huilai Ma1 Jianqun Zhang Ji Wang Ying Qin Cao Chen Yang Song Liang Wang Jun Meng Lingling Mao Fengqin Li Ning Li Jian Cai Yong Zhang Dayan Wang Yunting Xia Hong Wang Shaofeng Jiang Xiang Zhao Peihua Niu Wenjie Tan Tao Ma Yecheng Yao Naiying Mao Zhen Zhu Tianjiao Ji Qian Yang Baoying Huang Li Zhao Jianxing Yu Li Bai Shuangli Zhu Dongyan Wang Yan Zhang Yingwei Sun Mingchun Luan Yanhai Wang Haibo Sun Shihong Yang Zhijian Bo Xiang Ren Zhongjie Li George Fu Gao Wei Yao Wenqing Yao Zijian Feng Wenbo Xu | 2021 | China CDC weekly2021，3，21： | 16 |
| 14 | Trends and risk factors of lung cancer in China显示文摘China is faced with heavy burdens caused by lung cancer,which has climbed to the top of both cancer incidence and mortality spectrums.The age-standardized rates of incidence and mortality have shown a trend of gradual uptrends in the last decades,while the crude rates rise much quickly due to the aging of population.Although the improvement in health care has contributed to better survival of lung cancer,its prognosis is still challenging.Apart from the common risk factors such as tobacco use,air pollution,and occupational hazards,some specific factors like Chinese-style cooking also have posed great threats to human health.In light of such national conditions,specific interventions should be conducted to curb the burden of lung cancer including smoking cessation,improvement of air quality,early detection and effective treatment of lung cancer. | Siyi He He Li Maomao Cao Dianqin Sun Lin Lei Ni Li Ji Peng Wanqing Chen | 2020 | Chinese Journal of Cancer Research2020，32，6： | 16 |
| 15 | Association between Bmi1 and clinicopathological status of esophageal squamous cell carcinoma显示文摘AIM:To investigate the clinicopathological roles of Bmi1 in esophageal squamous cell carcinoma(ESCC) .METHODS:Quantitative real-time polymerase chain reaction and immunohistochemical staining for Bmi1 were performed in cancerous and adjacent non-cancerous paraffi n-embedded esophageal specimens.RESULTS:The Bmi1 expression level was unaffected by gender and age.The level of Bmi1 mRNA in ESCC was signif icantly higher than that in the adjacent non-cancerous tissues(2.181 ± 2.158 vs 0.931 ± 0.894,P = 0.0152) ,and its over-expression was aggressively associated with lymph node metastasis(3.580 ± 2.487 vs 1.703 ± 0.758,P = 0.0003) ,poorer cell differentiation(P = 0.0000) and advanced pathological stage(3.827 ± 2.673 vs 1.590 ± 0.735,P = 0.0001) .The patients were divided into high-expression and low-expression groups based on the median expression level of Bmi1 mRNA,and a shorter overall survival time in the former group was observed.Immunohistochemistry for Bmi1 oncoprotein showed diffusely positive,focally positive and negative expression in 44,16 and 10 of 70 ESCC cases,respectively,compared with three,two and five of 10 adjacent non-cancerous cases(P=0.027) .The positive rate of the oncoprotein in samples of histological grade was higher than that of grade(P=0.031) ,but its expression had no relation to the lymph node metastasis and pathological staging.In 70 ESCC samples,Bmi1 showed high intense expression in the cytoplasm and less or even no expression in the nucleus.CONCLUSION:Bmi1 was over-expressed in ESCC.Increased Bmi1 mRNA expression was significantly associated with ESCC progression,and the oncoprotein was largely distributed in the cytoplasm of tumor cells. | Xiao-Ting He Xiu-Feng Cao Lv Ji Bin Zhu Jin Lv Dong-Dong Wang Pei-Hua Lu Heng-Guan Cui | 2009 | World Journal of Gastroenterology2009，15，19： | 15 |
| 16 | The electromagnetic wave experiment for CSES mission: Search coil magnetometer显示文摘The seismic activities on the Earth can produce a disturbance of the electromagnetic field and particles in the ionosphere. The search coil magnetometer(SCM) mounted on China Seismo-Electromagnetic satellite(CSES) is designed to measure the magnetic field fluctuation of low frequency electromagnetic waves in the frequency range of 10 Hz–20 k Hz. The SCM comprises a three-axis search coil sensor mounted on a 4.5 m boom and an electronic box inside satellite module. The sampling rate of the SCM is 51.2 k Hz and the time resolution of the power spectrum density(PSD) is 2 s. The frequency resolution is 12.5 Hz.There are three operation modes: survey, detailed survey and calibration. In the survey mode, the SCM can provide a PSD in the whole frequency range of 10 Hz–20 k Hz and wave forms in the low frequency range below 2 k Hz while in the detailed survey mode the SCM can provide both PSD and wave forms in the whole frequency range of 10 Hz–20 k Hz. The sensitivity of the SCM instrument is 5.0×10^(-4) n T Hz^(-1/2) at 10 Hz, 5.0×10^(–5) n T Hz^(-1/2) at 200 Hz, 3.4×10^(-5) n T Hz^(-1/2) at 2 k Hz and 1.1×10^(-4) n T Hz^(-1/2) at 20 k Hz. The telemetry rate is ~0.85 Mbps in the survey mode and ~3.0 Mbps in the detailed survey mode. The phase difference between three axes can be made generally with a precision of less than 1.0°. The dynamic range of the SCM instrument is over 100 d B. The orthogonality of three mechanical axes of search coil senor is better than 0.13°. The performance of SCM can satisfy the requirement of scientific objectives of CSES mission. | CAO JinBin ZENG Li ZHAN Feng WANG ZuoGui WANG Yan CHEN Yu MENG QingChun JI ZhanQiang WANG PengFei LIU ZhongWei MA LingYu | 2018 | Science China(Technological Sciences)2018，61，5： | 13 |
| 17 | Long Distance Transmission of SARS-CoV-2 from Contaminated Cold Chain Products to Humans——Qingdao City,Shandong Province,China,September 2020显示文摘Summary What is already known about this topic?Though coronavirus disease 2019(COVID-19)has largely been controlled in China,several outbreaks of COVID-19 have occurred from importation of cases or of suspected virus-contaminated products.Though several outbreaks have been traced to severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)isolated on the outer packaging of cold chain products,live virus has not been obtained. | Huilai Ma Zhaoguo Wang Xiang Zhao Jun Han Yong Zhang Hong Wang Cao Chen Ji Wang Fachun Jiang Jie Lei Jingdong Song Shaofeng Jiang Shuangli Zhu Huihui Liu Dongyan Wang Yao Meng Naiying Mao Yanhai Wang Zhen Zhu Zhixiao Chen Bingling Wang Qinqin Song Haijun Du Qun Yuan Dong Xia Zhiqiang Xia Peipei Liu Yuchao Wu Zijian Feng Ruqin Gao George F.Gao Wenbo Xu | 2021 | China CDC weekly2021，3，30： | 13 |
| 18 | Eleven COVID-19 Outbreaks with Local Transmissions Caused by the Imported SARS-CoV-2 Delta VOC-China,July-August,2021显示文摘Starting from December 2019,Wuhan,China,encountered the first outbreak of coronavirus disease 2019(COVID-19)(1-2).The epidemic was successfully suppressed by strict containment so that the number of infected people was reduced to 0 on April 8,2020(3–4).After that,China experienced roughly 3 dozen outbreaks with local transmission caused by imported severe acute respiratory syndrome coronavirus 2(SARS-CoV-2). | Lei Zhou Kai Nie Hongting Zhao Xiang Zhao Bixiong Ye Ji Wang Cao Chen Hong Wang Jiangli Di Jinsong Li Chao Li Zhixiao Chen Ruiqi Ren Peihua Niu Hui Chen Tao Chen Yali Wang Lili Li Bingxue Han Ruhan A Si Chen Dan Li Dan Li Chunxia Jin Xin Zhang Jiangmei Liu Chunyu Xu Yecheng Yao Yenan Feng Zhili Li Bike Zhang Yang Song Peter Hao Yanping Zhang Hao Li Qun Li George F.Gao Guoqing Shi Wenbo Xu | 2021 | China CDC weekly2021，3，41： | 13 |
| 19 | Micro RNA-1290 promotes esophageal squamous cell carcinoma cell proliferation and metastasis显示文摘AIM:To investigate the biological role of mi R-1290 in esophageal squamous cell carcinoma(ESCC) progression and invasion and the underlying mechanism.METHODS:Quantitative real-time polymerase chain reaction(q RT-PCR) was performed to evaluate mi R-1290 expression in ESCC tissue samples.The roles of mi R-1290 in cell proliferation,migration and invasion were identified using mi R-1290 mimic-transfected cells.In addition,the regulatory effect of mi R-1290 on suppressor of cancer cell invasion(SCAI) was evaluated using q RT-PCR,Western blot analysis and a dual luciferase reporter assay.RESULTS:mi R-1290 was significantly upregulated in ESCC tissue samples compared with normal adjacent tissues(9.213 ± 1.150 vs 1.000 ± 0.0),(P < 0.01).Upregulation of mi R-1290 was associated with tumor differentiation(P = 0.021),N classification(P = 0.006) and tumor-node-metastasis stage(P = 0.021) in ESCC patients.Moreover,ectopic mi R-1290 expression potently promoted ESCC cell growth(P < 0.01),migration(P < 0.01) and invasion(P < 0.01) in vitro.mi R-1290 overexpression in ESCC cell lines decreased SCAI expression at the translational level and reduced SCAI-driven luciferase-reporter activity(P < 0.01).CONCLUSION:Our findings suggested that mi R-1290 may play an oncogenic role in cellular processes of ESCC. | Ming Li Xiao-Yan He Zhi-Mei Zhang Shuo Li Li-Hua Ren Ri-Sheng Cao Ya-Dong Feng Yin-Lin Ji Ye Zhao Rui-Hua Shi | 2015 | World Journal of Gastroenterology2015，21，11： | 13 |
| 20 | Identification of PRDX6 as a regulator of ferroptosis显示文摘Ferroptosis is a newly characterized iron-dependent form of nonapoptotic regulated cell death triggered by lipid reactive oxygen species(LOOH).The dysregulation of ferroptosis is highly related to cancer,and the induction of ferroptosis is also proposed as a potential strategy for cancer therapy.Although several key regulators have been identified that are involved in ferroptosis,the molecular mechanism underlying this process remains largely unknown.Here,we report that Peroxiredoxin-6(PRDX6)is a bona fide negative regulator of ferroptotic cell death.The knockdown of intracellular PRDX6 significantly enhances LOOH and ferroptotic cell death triggered by ferroptosis inducers(Erastin and RSL-3),which is correlated with the transcriptional activation of heme oxygenase-1.Moreover,overexpression of heme oxygenase-1 enhances both Erastin-and RSL-3-triggered LOOH,suggesting that heme oxygenase-1 mediates PRDX6 silencing-enhanced ferroptosis.More importantly,the application of a specific PRDX6 phospholipase A2(iPLA2)inhibitor,MJ-33,synergistically enhances the ferroptosis induced by Erastin,suggesting that PRDX6 removes LOOH through its iPLA2 activity.Thus,our findings reveal an essential role of PRDX6 in protecting cells against ferroptosis and provide a potential target to improve the antitumor activity of ferroptosis-based chemotherapy. | Bin Lu Xiao-bing Chen Yu-cai Hong Hong Zhu Qiao-jun He Bo Yang Mei-dan Ying Ji Cao | 2019 | Acta Pharmacologica Sinica2019，40，10： | 13 |
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