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| 1 | Integrated genomic analysis identifies deregulated JAK/STAT-MYC-biosynthesis axis in aggressive NK-cell leukemia显示文摘好攻击的 NK 房间白血病(ANKL ) 是在从亚洲的人之中是更流行的 NK 房间瘤的一种稀罕形式并且中央并且南美洲。病人们通常在天以内死到月,甚至在收到迅速的治疗学的管理以后。这里,我们由集成整个染色体执行了 ANKL 的第一全面研究, transcriptome 并且定序指向,象功能的试金一样的 cytokine 数组。在 JAK-STAT 小径的变化在 48% 被识别(14/29 ) ANKL 病人,当细胞外的 STAT3 激发器 IL10 被 56 褶层的一般水准提高时(P < 0.0001 ) 在检查的所有病人的血浆。另外的经常变异的基因包括的 TP53 (34%) , TET2 (28%) , CREBBP (21%) 和 MLL2 (21%) 。耐心的 NK 白血病房间在多重新陈代谢的小径显示出 STAT3 phosphorylation, MYC 表示和 transcriptional 活动的突出的激活。机能上地, STAT3 激活和 MYC 表示为 ANKL 房间的增长和幸存是批评的。发信号的 STAT 调整了发信号的 MYC 抄写节目,和两 STAT, MYC 抄写被要求维持核苷酸合成和 glycolysis 的激活。一起, JAK-STAT 小径在 ANKL 为 genomic 改变和 IL10 刺激代表一个主要目标。这最新发现的 JAK/STAT-MYC-biosynthesis 轴可以在对待白血病的这种子类型为新奇治疗学的策略的发展提供机会。 | Liang Huang Dan Liu Na Wang Shaoping Ling Yuting Tang Jun Wu Lingtong Hao Hui Luo Xuelian Hu Lingshuang Sheng Lijun Zhu Di Wang Yi Luo Zhen Shang Min Xiao Xia Mao Kuangguo Zhou Lihua Cao Lili Dong Xinchang Zheng Pinpin Sui Jianlin He Shanlan Mo Jin Yan Qilin Ao Lugui Qiu Hongsheng Zhou Qifa Liu Hongyu Zhang Jianyong Li Jie Jin Li Fu Weili Zhao Jieping Chen Xin Du Guoliang Qing Hudan Liu Xin Liu Gang Huang Ding Ma Jianfeng Zhou Qian-fei Wang | 2018 | Cell Research2018，28，2： | 5 |
| 2 | Biochemistry of mammalian ferritins in the regulation of cellular iron homeostasis and oxidative responses显示文摘Ferritin,an iron-storage protein,regulates cellular iron metabolism and oxidative stress.The ferritin structure is characterized as a spherical cage,inside which large amounts of iron are deposited in a safe,compact and bioavailable form.All ferritins readily catalyze Fe(II)oxidation by peroxides at the ferroxidase center to prevent free Fe(II)from participating in oxygen free radical formation via Fenton chemistry.Thus,ferritin is generally recognized as a cytoprotective stratagem against intracellular oxidative damage.The expression of cytosolic ferritins is usually regulated by iron status and oxidative stress at both the transcriptional and post-transcriptional levels.The mechanism of ferritin-mediated iron recycling is far from clarified,though nuclear receptor co-activator 4(NCOA4)was recently identified as a cargo receptor for ferritin-based lysosomal degradation.Cytosolic ferritins are heteropolymers assembled by H-and L-chains in different proportions.The mitochondrial ferritins are homopolymers and distributed in restricted tissues.They play protective roles in mitochondria where heme-and Fe/S-enzymes are synthesized and high levels of ROS are produced.Genetic ferritin disorders are mainly related to the L-chain mutations,which generally cause severe movement diseases.This review is focused on the biochemistry and function of mammalian intracellular ferritin as the major iron-storage and anti-oxidation protein. | Jianlin Zhang Xuehui Chen Juanji Hong Aifa Tang Yang Liu Ni Xie Guohui Nie Xiyun Yan Minmin Liang | 2021 | Science China(Life Sciences)2021，64，3： | 5 |
| 3 | 2021 Chinese consensus on the diagnosis and management of primary immune thrombocytopenia in pregnancy显示文摘Immune thrombocytopenia(ITP)is an acquired disease characterized by isolated thrombocytopenia,which is one of the most common causes of thrombocytopenia during pregnancy.Women with ITP who have severe thrombocytopenia are at an increased risk for life-threatening obstetric complications.Therefore,we established this consensus statement on the diagnosis and management of ITP during pregnancy(detailed information is available in the Supplementary File,http://links.lww.com7CM9/A978). | Zhang Xiaohui Chen Fangping Chen Xiequn Cheng Yunfeng Fang Meiyun Feng Jianming Fu Haixia Gao Hong Han Yue He Aili Hou Ming Hu Yu Huang Ruibin Huang Wenrong Jing Zhicheng Kong Peiyan Liang Aibin Liang Meiying Liu Daihong Liu Junling Liu Lin Liu Xiaowei Ma Liangming Mei Heng Ni Heyu Niu Ting Peng Jun Qiao Jianlin Ren Jinhai Song Yongping Tang Liang V Tong Tong Wang Shaoyuan Wang Xin Wang Zhao Wei Hui Wu Depei Wu Guangsheng Xu Caigang Xu Xue Xu Yajing Yang Linhua Yang Renchi Yang Tonghua Yin Chenghong Yu Li Zhang Guangsen Zhang Lei Zhang Liansheng Zhang Xi Zhao Weili Zhao Yongqiang Zhou Daobin Zhou Hu Zhou Zeping Zhu Tienan Wang Jianliu Huang Xiaojun | 2022 | Chinese Medical Journal2022，，8： | 2 |
| 4 | Dexmedetomidine maintains blood-brain barrier integrity by inhibiting Drp1-related endothelial mitochondrial dysfunction in ischemic stroke显示文摘Stroke is the second leading cause of death and long-term disability worldwide,which lacks effective treatment.Perioperative stroke is associated with much higher rates of mortality and disability.The neuroprotective role of dexmedetomidine(Dex),a highly selective agonist of alpha2-adrenergic receptor,has been reported in a stroke rat model,and it was found that pretreatment of Dex before stroke could alleviate blood–brain barrier(BBB)breakdown.However,the underlying mechanisms are still unknown.As the brain endothelial cells are the main constituents of BBB and in high demand of energy,mitochondrial function of endothelial cells plays an important role in the maintenance of BBB.Given that dynamin-related protein 1(Drp1)is a protein mediating mitochondrial fission,with mitochondrial fusion that balances mitochondrial morphology and ensures mitochondria function,the present study was designed to investigate the possible role of Drp1 in endothelial cells involved in the neuroprotective effects of Dex in ischemic stroke.Our results showed that preconditioning with Dex reduced infarction volume,alleviated brain water content and BBB damage,and improved neurological scores in middle cerebral artery occlusion rats.Meanwhile,Dex enhanced cell activity and decreased cell apoptosis in oxygen-glucose deprivation human brain microvascular endothelial cells in vitro.These protective effects of Dex were correlated with the mitochondrial morphology integrality of endothelial cells,mediated by increased phosphorylation of serine 637 in Drp1,and could be reversed byα2-adrenergic receptor antagonist Yohimbine and AMP-activated protein kinase inhibitor Compound C.These findings suggest new molecular pathways involved in the neuroprotective effects of Dex in ischemic stroke.As Dex is routinely used as a sedative drug clinically,our findings provide molecular evidence that it has perioperative neuroprotection from ischemic stroke. | Wei Zhou Yunchun Zhang Yingfu Jiao Wen Yin Haiping Dong Saihong Xu Dan Tang Junli Jiang Jianlin Shao Zhenhong Wang Weifeng Yu | 2021 | Acta Biochimica et Biophysica Sinica2021，53，9： | 2 |
| 5 | Effect of berberine on Cdk9 and cyclin T1 expressions in myocardium of diabetic rats显示文摘ObjectiveTo 调查小檗硷的效果,主要的碱之一黄连,在心肌的形态学和cyclin依赖的激酶的表情上 9 ( Cdk9 )并且在类型 2 糖尿病的 rats.MethodsType 的心肌层的 cyclin T1 蛋白质 2 只糖尿病老鼠被 35 mg/kg streptozotocin ( STZ )的注射导致, high-carbohydrate/high-fat 节食 16 个星期。糖尿病的老鼠被给低 -- ,中间 -- ,高剂量的小檗硷(75, 150, 300 mg/kg ) , fenofibrate (100 mg/kg ) 和为另外一个的 rosiglitazone (4 mg/kg ) 16 个星期分别地。心肌层结构与染色的苏木精与曙红和 Cdk9 (H&E ) 被观察, cyclin T1 蛋白质表情被 immunohistochemistry.ResultsMiddle 剂量检测,高剂量的小檗硷改进了心肌的肥大和糖尿病的老鼠的空隙的纤维变性。 Cdk9 和 cyclin T1 蛋白质比在控制一在糖尿病的心肌层是显著地更低的( P <
0.01 ),并且中间剂量,高剂量的小檗硷和 fenofibrate 显然增加了 Cdk9 和 cyclin T1 表示近控制水平( P <
0.01 ) .ConclusionsBerberine 在可以贡献的糖尿病的心肌层调制 Cdk9 和 cyclin T1 蛋白质表示改善心肌层损坏。 | Zhou Jiyin Zhou Shiwen Tang Jianlin Xu Ying Ying Yi | 2008 | Journal of Medical Colleges of PLA(China)2008，23，1： | 2 |
| 6 | Chronological and Geochemical Study of the Cenozoic Potassic Felsic Igneous Rocks in Western Yunnan,SE Tibet:Implications for their Tectonic Mechanisms显示文摘Whether there is a relationship between widespread Cenozoic igneous rocks and the activated Ailao Shan-Red River shear zone(ASRR)in western Yunnan,SE Tibet,remains highly controversial.New geochronological,and geochemical data derived from Cenozoic igneous rocks both within and far from the ASRR offers answers.Although these coeval felsic rocks(36.9-33.5 Ma)are enriched in large-ion lithophile elements relative to high field strength elements,they also display some special geochemical features,such as high Y and Yb values of syenitic porphyries,which contrast with the high Sr and low Y contents of monzoporphyries and granitic porphyries.The syenitic porphyries exhibit geochemical characteristics similar to those of coeval mafic magmas,e.g.,high K 2 O,Y,and Yb contents,indicating that the former were probably generated by fractional crystallization of the latter.However,the high Sr/Y(56.1-109)monzoporphyries and granitic porphyries,combined with their low MgO,and Cr(or Ni)contents,suggest that they were mainly derived from partial melting of a thickened mafic lower crust.Given that these Cenozoic magmatic events exhibiting planar distributions occurred outside of the activation of the ASRR(31-20 Ma),then they were not controlled by the latter.Instead,they were tied to convective removal of a thickened lower lithospheric mantle in western Yunnan during the Paleogene. | TANG Wanli CHEN Jianlin TAN Rongyu | 2022 | Acta Geologica Sinica(English Edition)2022，96，3： | 1 |
| 7 | Contrasting effects of straw and straw-derived biochar amendments on greenhouse gas emissions within double rice cropping systems显示文摘 | Jianlin Shen Hong Tang Jieyun Liu Cong Wang Yong Li Tida Ge Davey L. Jones Jinshui Wu | 2014 | Agriculture Ecosystems and Environment2014，，： | 1 |
| 8 | Impacts of Pollution Controls on Air Quality in Beijing during the 2008 Olympic Games显示文摘 | Shen Jianlin Tang Aohan Liu Xuejun Kopsch Jenny Fangmeier Andreas Goulding Keith Zhang Fusuo | 2011 | EN2011，，1： | 1 |
| 9 | High concentrations and dry deposition of reactive nitrogen species at two sites in the North China Plain显示文摘 | Shen Jianlin Tang Aohan Liu Xuejun | 2009 | Environmental Pollution2009，157，11： | 1 |
| 10 | Emerging two-dimensional material nanozymes for theranostic nanomedicine显示文摘Nanomaterials-based artificial enzymes(nanozymes)with valuable enzyme-like catalytic properties have been booming during the past few years.Promoted by the advances in biological medicine and nanotechnology,nanozymes possess the potential to serve as an emerging agent for biosensing,immunoassays,detection and diagnosis,catalytic therapeutics,and other applications in the biomedicine field.Two-dimensional(2D)nanomaterials are of considerable interest in biomedical applications due to their ultrathin layered structure and unique physiochemical properties.Inspired by the diversified catalytic performance of 2D nanomaterials,scientists extensively have developed 2D materials as bioactive nanozymes for theranostic nanomedicine.Here,recent advances in enzyme-like 2D nanomaterials design and construction are comprehensively presented.Additionally,we exhibit that,with the synergistic effect of catalytic activities and desirable physicochemical performances,2D nanozymes can serve as versatile platforms with extensive applications from target detection to in vivo theranostic.It is believed that such promising alternatives towards natural enzymes will be of vital significance in the field of nanotechnology and biomedicine. | Yanling You Zhongmin Tang Han Lin Jianlin Shi | 2021 | Biophysics Reports2021，7，3： | 1 |
| 11 | Lessons learned from the Wenchuan earthquake显示文摘 | Ji Shen Junxing Kang Yingkang Shi Youping Li Yuanfeng Li Lin Su Jianlin Wu Shangwei Zheng Jie Jiang Weijian Hu Yong Yang Xuefeng Tang Jin Wen Ling Li Jiantong Shen Dake Zhong | 2012 | Journal of Evidence‐Based Medicine2012，，2： | 1 |
| 12 | A Unified Time Scale Intelligent Control Algorithm for Microgrid Based on Extreme Dynamic Programming显示文摘Benefiting from the progress of power electronics technology,distributed generation technology is developing rapidly.Since microgrids cannot rely on traditional multi-time scale control strategies to ensure the high-quality frequency stability control and economic dispatch in the same time scale,this paper proposes an extreme dynamic programming algorithm.The proposed algorithm takes an adaptive dynamic programming algorithm as the framework,an extreme learning machine as a kernel of the evaluation module,a model module,an implementation module and a new prediction module.The resulting unified time scale intelligent control algorithm better realizes the combined functions of“droop control+automatic generation control+economic dispatch”in the traditional opermode.Finally,in order to verify the effectiveness of the proposed algorithm,a microgrid model of 8 nodes is simulated.The results confirm the feasibility and validity of the proposed extreme dynamic programming algorithm. | Junbin Chen Tao Yu Linfei Yin Jianlin Tang Hanqi Wang | 2020 | CSEE Journal of Power and Energy Systems2020，6，3： | 0 |
| 13 | Aging Resistance Evaluation of Aged Paper Reinforced with Different Nanocelluloses显示文摘Paper documents experience severe acidification and embrittlement.Nanocellulose is an excellent reinforcement material for paper documents owing to its compatibility and excellent mechanical strength.However,little research has been conducted on the aging resistance of nanocellulose-reinforced paper.In this study,six types of nanocelluloses were used to reinforce aged paper.The reinforcement and anti-aging performances were evaluated,and the anti-aging mechanism was further clarified.Nanocellulose with a high degree of polymerization can better enhance aged paper,and non-chemical nanocellulose also shows better anti-aging performance,such as nanocellulose prepared by mechanical or biological methods.However,nanocellulose prepared using chemical methods exhibits poor reinforcement and anti-aging performance.This is because it has a small particle size that is not beneficial for physical crosslinking with paper fibers.More importantly,the introduction of acidic or oxidizing groups on nanocellulose accelerates the acid hydrolysis and oxidation rate of paper fibers,especially nanocellulose prepared by 2,2,6,6-tetramethylpiperidine-1-oxyl oxidation,which should not be used to protect paper documents. | Xian Cao Bei He Jianlin Wang Chunhui Zhang Donglin Tang Qingyou Liang Chuanfu Liu Huiming Fan Junli Ren | 2023 | Paper And Biomaterials2023，8，3： | 0 |
| 14 | A natural nanozyme in life is found:the iron core within ferritin shows superoxide dismutase catalytic activity显示文摘Nanozymes are nanomaterials exhibiting intrinsic enzymatic properties,which suggests that inorganic nanoparticles could be bioactive.It’s in 2007,when we introduced the biological methodologies for natural enzymes to systematically study the enzymatic properties of iron oxide nanoparticles,we discovered nanozymes.We found that nanozymes,just as natural enzymes,are able to catalyze biochemical reactions under the physiological conditions,following the similar enzymatic kinetics and catalytic mechanisms(Gao et al.,2007).Since then,the developments of nanozymes bloomed,and lots of nanomaterials were found exhibiting various enzymatic activities(Huang et ah,2019). | Jianlin Zhang Shimin Li Ni Xie Guohui Nie Aifa Tang Xian-En Zhang Minmin Liang Xiyun Yan | 2021 | Science China(Life Sciences)2021，64，8： | 0 |
| 15 | Highly robust spatiotemporal wavefront prediction with a mixed graph neural network in adaptive optics显示文摘The time-delay problem,which is introduced by the response time of hardware for correction,is a critical and nonignorable problem of adaptive optics(AO)systems.It will result in significant wavefront correction errors while turbulence changes severely or system responses slowly.Predictive AO is proposed to alleviate the time-delay problem for more accurate and stable corrections in the real time-varying atmosphere.However,the existing prediction approaches either lack the ability to extract non-linear temporal features,or overlook the authenticity of spatial features during prediction,leading to poor robustness in generalization.Here,we propose a mixed graph neural network(MGNN)for spatiotemporal wavefront prediction.The MGNN introduces the Zernike polynomial and takes its inherent covariance matrix as physical constraints.It takes advantage of conventional convolutional layers and graph convolutional layers for temporal feature catch and spatial feature analysis,respectively.In particular,the graph constraints from the covariance matrix and the weight learning of the transformation matrix promote the establishment of a realistic internal spatial pattern from limited data.Furthermore,its prediction accuracy and robustness to varying unknown turbulences,including the generalization from simulation to experiment,are all discussed and verified.In experimental verification,the MGNN trained with simulated data can achieve an approximate effect of that trained with real turbulence.By comparing it with two conventional methods,the demonstrated performance of the proposed method is superior to the conventional AO in terms of root mean square error(RMS).With the prediction of the MGNN,the mean and standard deviation of RMS in the conventional AO are reduced by 54.2%and 58.6%at most,respectively.The stable prediction performance makes it suitable for wavefront predictive correction in astronomical observation,laser communication,and microscopic imaging. | JU TANG JI WU JIAWEI ZHANG MENGMENG ZHANG ZHENBO REN JIANGLEI DI LIUSEN HU GUODONG LIU JIANLIN ZHAO | 2023 | Photonics Research2023，11，11： | 0 |
| 16 | A Novel Vascular Disrupting Agents Noncovalent Polymeric Nanomedicine:Significantly Increased Antitumor Therapeutic Efficiency显示文摘This work was supported by the National Natural Science Foundation of China(Nos.52025035,52103195).The comprehensive graphic content and graphic abstract were created with BioRender.com by coauthors. | Jianlin Lv Yajun Xu Yue Huang Haiyang Yu Zhaohui Tang | 2022 | Chinese Journal of Chemistry2022，40，12： | 0 |
| 17 | Effects of Microbial Pesticides on Prevention and Control of Cucumber Downy Mildew显示文摘This experiment was carried out to explore the effects of microbial pesticides on prevention and control of cucumber downy mildew.Three kinds of microbial pesticides( Recharge,Dynamic F,and 3. 0% amino-oligosaccharin AS) were used and clean water was taken as the control( CK). The experiment showed that Recharge and 3. 0% amino-oligosaccharin AS had better control effect on cucumber downy mildew.After the first application,the average control effect of Recharge and 3. 0% amino-oligosaccharin AS was higher than 50%. After the third application,the average control effect of Recharge and 3. 0% amino-oligosaccharin AS was higher than 20%. The control effect of Dynamic F on cucumber downy mildew was relatively poor,and the average control effect after the first application was 38. 34%,and the average control effect after the third application was only 15. 64%. According to the experimental results,the average control effect of three pesticides after application showed a gradual decline trend. | Jingqin TANG Hengjuan LUN Chunhui ZHAO Minzheng YUN Yuefeng MA Jianlin WANG | 2019 | Asian Agricultural Research2019，11，8： | 0 |
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