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| 1 | Genome-wide analysis of heat shock transcription factor families in rice and Arabidopsis显示文摘The heat shock transcription factors (HSFs) are the major heat shock factors regulating the heat stress response. They participate in regulating the expression of heat shock proteins (HSPs), which are critical in the protection against stress damage and many other important biological processes. Study of the HSF gene family is important for understanding the mechanism by which plants respond to stress. The completed genome sequences of rice (Oryza sativa) and Arabidopsis (Arabidopsis thaliana) constitute a valuable resource for comparative genomic analysis, as they are representatives of the two major evolutionary lineages within the angiosperms: the monocotyledons and the dicotyledons. The identification of phylogenetic relationships among HSF proteins in these species is a fundamental step to unravel the functionality of new and yet uncharacterized genes belonging to this family.In this study, the full complement of HSF genes in rice and Arabidopsis has probably been identified through the genome-wide scan. Phylogenetic analyses resulted in the identification of three major clusters of orthologous genes that contain members belonging to both species, which must have been represented in their common ancestor before the taxonomic splitting of the angiosperms. Further analysis of the phylogenetic tree reveals a possible dicot specific gene group. We also identified nine pairs of paralogs, as evidence for studies on the evolution history of rice HSF family and rice genome evolution. Expression data analysis indicates that HSF proteins are widely expressed in plants. These results provide a solid base for future functional genomic studies of the HSF gene family in rice and Arabidopsis. | Jingkang Guo Jian Wu Qian Ji Chao Wang Lei Luo Yi Yuan Yonghua Wang Jian Wang | 2008 | Journal of Genetics and Genomics2008，35，2： | 52 |
| 2 | Recent Developments in the Crystallization Process: Toward the Pharmaceutical Industry显示文摘 | Zhenguo Gao Sohrab Rohani Junbo Gong Jingkang Wang | 2017 | Engineering2017，3，3： | 16 |
| 3 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 4 | The High Energy X-ray telescope (HE) onboard the Insight-HXMT astronomy satellite显示文摘The Insight-Hard X-ray Modulation Telescope(Insight-HXMT) is a broadband X-ray and γ-ray(1-3000 ke V) astronomy satellite. One of its three main telescopes is the High Energy X-ray telescope(HE). The main detector plane of HE comprises 18 Na I(Tl)/Cs I(Na) phoswich detectors, where Na I(Tl) is used as the primary detector to measure ~ 20-250 ke V photons incident from the field of view(FOV) defined by collimators, and Cs I(Na) is used as the active shielding detector to Na I(Tl) by pulse shape discrimination. Additionally, Cs I(Na) is used as an omnidirectional γ-ray monitor. The HE collimators have a diverse FOV,i.e. 1.1°×5.7°(15 units), 5.7°×5.7°(2 units), and blocked(1 unit). Therefore, the combined FOV of HE is approximately5.7°×5.7°. Each HE detector has a diameter of 190 mm resulting in a total geometrical area of approximately 5100 cm2, and the energy resolution is ~15% at 60 ke V. For each recorded X-ray event by HE, the timing accuracy is less than 10 μs and the deadtime is less than 10 μs. HE is used for observing spectra and temporal variability of X-ray sources in the 20-250 ke V band either by pointing observations for known sources or scanning observations to unveil new sources. Additionally, HE is used for monitoring the γ-ray burst in 0.2-3 Me V band. This paper not only presents the design and performance of HE instruments but also reports results of the on-ground calibration experiments. | CongZhan Liu YiFei Zhang XuFang Li XueFeng Lu Zhi Chang ZhengWei Li AiMei Zhang YongJie Jin HuiMing Yu Zhao Zhang MinXue Fu YiBao Chen JianFeng Ji YuPeng Xu JingKang Deng RenCheng Shang GuoQing Liu FangJun Lu ShuangNan Zhang YongWei Dong TiPei Li Mei Wu YanGuo Li HuanYu Wang BoBing Wu YongJie Zhang Zhi Zhang ShaoLin Xiong Yuan Liu Shu Zhang HongWei Liu YiJung Yang Fan Zhang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 9 |
| 5 | Phase equilibria for the pseudo-ternary system(NaCl+Na2SO4+H2O)of coal gasification wastewater at T=(268.15 to 373.15)K显示文摘The pseudo-ternary system(Na Cl + Na_2SO_4+ H_2O) of coal gasification wastewater was studied at T =(268.15 to 373.15) K. The solubility and density of the equilibrium liquid phase were determined by the isothermal solution saturation method. The equilibrium solids were also investigated by the Schreinemaker's method of wet residues and X-ray powder diffraction(XRD). According to the experimental data, the phase diagrams were determined. It was found that there was no significant solubility difference on the Na Cl-rich side between the ternary system(Na Cl + Na_2SO_4+ H_2O) in coal gasification wastewater and in pure water. However, the solubility on the Na_2SO_4-rich side of coal gasification wastewater was apparently higher than that of pure water. The increase in the solubility of Na_2SO_4 was most likely caused by the effects of other impurities apart from Na Cl and Na_2SO_4 in coal gasification wastewater. The measured data and phase equilibrium diagrams can provide fundamental basis for salt recovery in coal gasification wastewater. | Haijiao Lu Jingkang Wang Jun Yu Yuefeng Wu Ting Wang Ying Bao Dou Ma Hongxun Hao | 2017 | Chinese Journal of Chemical Engineering2017，25，7： | 7 |
| 6 | Progress of Pharmaceutical Continuous Crystallization显示文摘 | Dejiang Zhang Shijie Xu Shichao Du Jingkang Wang Junbo Gong | 2017 | Engineering2017，3，3： | 5 |
| 7 | Tetrahydroisoquinolines as novel histone deacetylase inhibitors for treatment of cancer显示文摘Histone acetylation is a critical process in the regulation of chromatin structure and gene expression.Histone deacetylases(HDACs)remove the acetyl group,leading to chromatin condensation and transcriptional repression.HDAC inhibitors are considered a new class of anticancer agents and have been shown to alter gene transcription and exert antitumor effects.This paper describes our work on the structural determination and structure-activity relationship(SAR)optimization of tetrahydroisoquinoline compounds as HDAC inhibitors.These compounds were tested for their ability to inhibit HDAC 1,3,6 and for their ability to inhibit the proliferation of a panel of cancer cell lines.Among these,compound 82 showed the greatest inhibitory activity toward HDAC 1,3,6 and strongly inhibited growth of the cancer cell lines,with results clearly superior to those of the reference compound,vorinostat(SAHA).Compound 82 increased the acetylation of histones H3,H4 and tubulin in a concentration-dependent manner,suggesting that it is a broad inhibitor of HDACs. | Danqi Chen Aijun Shen Guanghua Fang Hongchun Liu Minmin Zhang Shuai Tang Bing Xiong Lanping Ma Meiyu Geng Jingkang Shen | 2016 | Acta Pharmaceutica Sinica B2016，6，1： | 4 |
| 8 | Overcoming oral insulin delivery barriers: application of cell penetrating peptide and silica-based nanoporous composites显示文摘 | Huining HE Junxiao YE Jianyong SHENG Jianxin WANG Yongzhuo HUANG Guanyi CHEN Jingkang WANG Victor C YANG | 2013 | Frontiers of Chemical Science and Engineering2013，7，1： | 3 |
| 9 | Relationship between hyperlipidemia and the gut microbiome of rats, characterized using high-throughput sequencing显示文摘Objective:To determine the effects of a high-fat diet(HFD)on the gut microbiome in rats,to explore the relationship between the intestinal flora and blood lipid profile.Methods:SpragueeDawley rats were fed an HFD for four weeks to induce hyperlipidemia,then 16S rRNA sequencing was used to compare the intestinal flora between hyperlipidemic and control diet-fed rats.Results:The microbiome of rats fed an HFD for four weeks differed from that of control diet-fed rats.Bacterial species that were less abundant were most affected by HFD feeding,among which were many pathogenic species,which became significantly more abundant.Eighteen genera were present in significantly different numbers in hyperlipidemic and control rats,more than half of which have been linked to infection and inflammation,or energy intake and obesity.The results indicated a type of stress response of the flora to a high-fat environment.In addition,the age of the rats tended to influence the gut microbial composition.Conclusion:These findings suggest that HFD may induce hyperlipidemia by affecting the gut microbial composition.Changes in the abundance of pro-inflammatory and pathogenic bacteria,and those that influence energy intake and obesity,may be important mediators of this. | Yaqi Li Quantao Ma Jingkang Wang Pengfei Li Long Cheng Yongcheng An Yuhui Duan Hongyu Dai Ting Wang Baosheng Zhao | 2020 | Journal of Traditional Chinese Medical Sciences2020，7，2： | 3 |
| 10 | Discovery of a series of dimethoxybenzene FGFR inhibitors with 5H-pyrrolo[2,3-b]pyrazine scaffold: structure–activity relationship, crystal structural characterization and in vivo study显示文摘Genomic alterations are commonly found in the signaling pathways of fibroblast growth factor receptors(FGFRs). Although there is no selective FGFR inhibitors in market, several promising inhibitors have been investigated in clinical trials, and showed encouraging efficacies in patients. By designing a hybrid between the FGFR-selectivity-enhancing motif dimethoxybenzene group and our previously identified novel scaffold, we discovered a new series of potent FGFR inhibitors, with the best one showing sub-nanomolar enzymatic activity. After several round of optimization and with the solved crystal structure, detailed structure–activity relationship was elaborated. Together with in vitro metabolic stability tests and in vivo pharmacokinetic profiling, a representative compound(35) was selected and tested in xenograft mouse model, and the result demonstrated that inhibitor 35 was effective against tumors with FGFR genetic alterations, exhibiting potential for further development. | Peng Wei Bo Liu Ruifeng Wang Yinglei Gao Lanlan Li Yuchi Ma Zhiwei Qian Yuelei Chen Maosheng Cheng Meiyu Geng Jingkang Shen Dongmei Zhao Jing Ai Bing Xiong | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 2 |
| 11 | Overview to the Hard X-ray Modulation Telescope (Insight-HXMT) Satellite显示文摘As China’s first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band(1-250 ke V) slat-collimator-based X-ray astronomy satellite with the capability of all-sky monitoring in 0.2-3 Me V. It was designed to perform pointing, scanning and gamma-ray burst(GRB)observations and, based on the Direct Demodulation Method (DDM), the image of the scanned sky region can be reconstructed.Here we give an overview of the mission and its progresses, including payload, core sciences, ground calibration/facility, ground segment, data archive, software, in-orbit performance, calibration, background model, observations and some preliminary results. | Shuang-Nan Zhang TiPei Li FangJun Lu LiMing Song YuPeng X u CongZhan Liu Yong Chen XueLei Cao QingCui Bu Zhi Chang Gang Chen Li Chen TianXiang Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong Yuan Yuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan Can Gungor ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge Ou JinLu Qu Na Sai RenCheng Shang GuoHong Shen Liang Sun Ying Tan Lian Tao YouLi Tuo Chen Wang ChunQin Wang GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BaiYang Wu BoBing Wu Mei Wu GuangCheng Xiao ShaoLin Xiong LinLi Yan JiaWei Yang Sheng Yang YanJi Yang QiBin Yi Bin Yuan AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang ShenYi Zhangs Shu Zhang Tong Zhang WanChang Zhang Wei Zhang WenZhao Zhang Yi Zhang YiFei Zhang YongJie Zhang Yue Zhang Zhao Zhang Zhi Zhang ZiLiang Zhang HaiSheng Zhao XiaoFan Zhao ShiJie Zheng JianFeng Zhou YuXuan Zhu Yue Zhu RenLin Zhuang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 2 |
| 12 | Significance and strategies in developing delivery systems for bio-macromolecular drugs显示文摘 | Huining HE Qiuling LIANG Meong Cheoi SHIN Kyuri LEE Junbo GONG Junxiao YE Quan LIU Jingkang WANG Victor YANG | 2013 | Frontiers of Chemical Science and Engineering2013，7，4： | 2 |
| 13 | Solubility of dexamethasone sodium phosphate in different solvents显示文摘 | Hao Hongxun Wang Jingkang Wang Yongli | 2004 | Journal of Chem Eng Data2004，49，6： | 1 |
| 14 | Fast determination of tobramycin by reversed-phase ion-pair high performance liquid chromatography with a refractive index detector显示文摘 | Liang ZHU Jingkang WANG | 2013 | Frontiers of Chemical Science and Engineering2013，7，3： | 1 |
| 15 | The solubility of cefquinome sulfate in pure and mixed solvents显示文摘cefquinome 硫酸盐的稳固液体的平衡数据是重要的为 cefquinome 硫酸盐开发工业结晶化过程。在从 277.15 ~ 305.15 K 的五纯溶剂(甲醇,乙醇,乙烯乙二醇,醋酸和水) 并且在从 278.15 ~ 293.15 K 的二进制丙酮水溶剂的 cefquinome 硫酸盐的溶解度在气压被测量。而混合溶剂系统数据被相关到修改 Apelblat, Vant Hoff, CNIBS/R-K 和 Jouyban- Acree 模型,纯溶剂的溶解度数据被相关到修改 Apelblat 和 Vant Hoff 方程。在所有测试溶剂的 cefquinome 硫酸盐的溶解度与增加温度减少了,这被发现。另外,包括免费精力,热含量和熵改变的标准吉布斯,溶解过程的热力学的性质用 Vant Hoff 方程被计算。cefquinome 硫酸盐的溶解是发热的,这被发现。 | Rongbao Qi Jingkang Wang Junxiao Ye Hongxun Hao Ying Bao | 2016 | Frontiers of Chemical Science and Engineering2016，10，2： | 1 |
| 16 | Molecular mechanism of crystal nucleation from solution显示文摘Nucleation from solution is fundamental to many natural and industrial processes.The understanding of molecular mechanism of nucleation from solution is conducive to predict crystal structure,control polymorph and design desired crystal materials.In this review,the nucleation theories,including classical nucleation theory(CNT),nonclassical nucleation theory,as well as other new proposed theories,were reprised,and the molecular mechanism of these theories was compared.Then,the molecular process of nucleation,including the current study techniques,the effect of molecular self-assembly in solutions,desolvation process,as well as the properties of solvent and crystal structure on nucleation from solution were summarized.Furthermore,the relationship of molecular conformation in solution and in crystal,and the effect of solute molecular flexibility on nucleation were discussed.Finally,the current challenges and future scopes of crystal nucleation from solution were discussed. | Xin Li Jingkang Wang Ting Wang Na Wang Shuyi Zong Xin Huang Hongxun Hao | 2021 | Science China Chemistry2021，64，9： | 1 |
| 17 | Performance of parallel combinatory spread spectrum multiple access communication systems 显示文摘 | SASAKI S ZHU Jingkang | 1991 | Personal Indoor and Mobile Radio Communications1991，3，： | 1 |
| 18 | Solubility of sodium eefotaxime in aqueous 2-propanol mixtures显示文摘 | Zhang Haitao Wang Jingkang Chen Ying | 2006 | J Chem Eng Data2006，51，： | 1 |
| 19 | Rapid sonocrystallization in the salting-out process 显示文摘 | Li Hong Wang Jingkang Bao Ying | 2003 | Journal of Crystal Growth2003，247，1： | 1 |
| 20 | Investigation on the spherical crystallization process of cefotaxime sodium显示文摘 | Zhang Haitao Chen Ying Wang Jingkang Gong Junbo | 2009 | Industrial & Engineering Chemistry Research2009，49，3： | 1 |
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