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| 1 | Effects of Land Use Change on Ecosystem Services in Arid Area Ecological Migration显示文摘Ecological migration is the process of increasing the population density in the immigration area and transferring the ecological pressure from emigration area to immigration area. This process may result in significant changes in land use and land cover in the area of immigration and have an important effect on ecosystem services. Therefore, scientifically revealing the effects and differentiation mechanisms of ecological migration on ecosystem services is becoming an important issue related to the implementation of the national ecological migration strategy in China. This study employed the Hongsibu District as a typical example of ecological migration. Hongsibu District is located in the central Ningxia steppe and desert steppe areas. Remote sensing data covering five periods from the period before ecological migration in 1995 and after migration in 2000, 2005, 2010, and 2015 was used to measure the value of ecosystem services(ESV). A geographical detector model and the value of ecosystem services model were used to diagnose the dynamic mechanism of the effects of land use change on ecosystem services. The results showed that: 1) The development of large-scale ecological resettlement has caused the area of cultivated land and urbanized land area to increase significantly in the area of immigration, while the grass area decreased significantly. 2) The overall value of the Hongsibu ecosystem services increased in a form of a ‘V'. Among them, during the period of 1995–2005, the overall ESV decreased and had an annual rate of change of-0.67%. During the period of development 2005–2015, the ESV increased steadily, with an annual rate of change of 0.79%. 3) The proportion and total ESV in soil formation and protection, waste treatment, and biodiversity conservation of the Hongsibu District decreased from 57.61% in 1995 to 56.17% in 2015, indicating that the region's ecological regulation function slightly decreased. 4) The ESV in the Hongsibu District, showed a low distribution pattern of ecosystem services increasing from northeast to southwest, and the capacity of three townships, Hongsibu, Taiyangshan, and Liuquan, to provide ecosystem services gradually declined over time. The ecological service function of Xinzhuangji Township and Dahe Township gradually improved. 5) The sensitivity index of the ESV of each land use type was less than 1, indicating that the environment lacks flexibility in providing a strong ESV index in Hongsibu, which shows that the research results are reliable and believable. 6) During the study period, the decisive force of the change of land use on ecosystem services in Hongsibu District was: grassland(0.9934), climate regulation(0.9413), soil formation and protection(0.9321) and waste treatment(0.9241). | LIU Xiaopeng CHEN Xiao HUA Kaiping WANG Yajuan WANG Peng HAN Xiaojia YE Junyan WEN Shengqiang | 2018 | Chinese Geographical Science2018，28，5： | 9 |
| 2 | Perovskite thin-film solar cell: excitation in photovoltaic science显示文摘As a new member of thin-film solar cells,the perovskite solar cells have inspired a new research hot in new photoelectric materials and devices,and have given a new energy to the photovoltaic science.Currently,various device structures,including mesoporous and planar,with and without hole transport material have been developed.In this review,much focus has been addressed to the deposition of high-quality perovskite films,structural optimization,and interface engineering as well as the understanding of the charge generation,transport,and recombination mechanisms of the devices.Furthermore,cost,stability,and environment issues of the cell are also discussed for commercial application. | Junyan Xiao Jiangjian Shi Dongmei Li Qingbo Meng | 2015 | Science China Chemistry2015，58，2： | 6 |
| 3 | Reversible self-assembly of gold nanorods mediated by photoswitchable molecular adsorption显示文摘Stimuli-responsive self-assembly of nanoparticles represents a powerful strategy to achieve reconfigurable materials with novel functionalities and promising applications.In this regard,light-induced reversible self-assembly (LIRSA) of nanoparticles is most attractive but it is usually limited by the prerequisite yet cumbersome chemical functionalizations of the particle surface.Here we describe an innovative method to realize LIRSA of gold nanorods (GNRs) without surface functionalization through photoswitchable adsorption of an anionic azobenzene derivate AzoNa.The LIRSA of GNRs is caused by the reversible change between a nearly neutral state and a highly charged state of the GNRs arising from the photoswichable adsorption of AzoNa triggered by photoisomerization.The LIRSA behavior can be readily adjusted by changing the concentration of AzoNa and the aspect ratio of the GNRs.This new LIRSA strategy may provide a convenient and efficient route toward light-triggered reversibly reconfigurable nanomaterials. | Qian Wang Di Li Junyan Xiao Fucheng Guo Limin Qi | 2019 | Nano Research2019，12，7： | 2 |
| 4 | Surfactant - assisted, shape - controlled synthesis of gold nanocrystals 显示文摘 | Junyan Xiao Limin Qi | 2011 | Nanoscale2011，，3： | 1 |
| 5 | Efficient CHzNHzPbl3 perovskite solar cells with 2TPA- n-DP hole-transporting layers显示文摘 | Lifeng Zhu Junyan Xiao Jiangjian Shi Junjie Wang Songtao Lv Yuzhuan Xu Yanhong Luo YinXiao Shirong Wang Qingbo Meng Xianggao Li Dongmei Li | 2015 | Nano Research2015，8，4： | 1 |
| 6 | Ultrasonic extraction and determination of cyanuric acid in pet food 显示文摘 | CHEN YU LIHUA ZHU JUNYAN XIAO | 2009 | Food Control2009，20，1： | 1 |
| 7 | Flavipin in Chaetomium globosum CDW7, an endophytic fungus from Ginkgo biloba , contributes to antioxidant activity显示文摘 | Yonghao Ye Yu Xiao Liang Ma Hongxia Li Zhenglu Xie Minghua Wang Haitian Ma Huaiwu Tang Junyan Liu | 2013 | Applied Microbiology and Biotechnology2013，，16： | 1 |
| 8 | In-situ monitored chemical bath deposition of planar NiO x layer for inverted perovskite solar cell with enhanced efficiency显示文摘As a convenient,low-cost and up-scalable solution route,chemical bath deposition(CBD)has exhibited impressive advantages in fabricating electron transporting materials like SnO_(2),achieving record efficien-cies for regular n-i-p perovskite solar cells(PSCs).However,for the hysteresis-free and potentially more stable inverted p-i-n PSCs,CBD processing is rarely studied to improve the device performance.In this work,we first present a CBD planar NiO x film as the efficient hole transport layer for the inverted per-ovskite solar cells(IPSCs).The morphologies and semiconducting properties of the NiO x film can be ad-justed by varying the concentration of[Ni(H 2 O)x(NH 3)6-x]2+cation via in-situ monitoring of the CBD re-action process.The characterizations of ultraviolet photoelectron spectroscopy,transient absorption spec-troscopy,time-resolved photoluminescence suggest that the CBD planar NiO x film possesses enhanced conductivity and aligned energy band levels with perovskite,which benefits for the charge transport in the IPSCs.The devices based on planar NiO x at 50°C and low nickel precursor concentration achieved an enhanced efficiency from 16.14%to 18.17%.This work established an efficient CBD route to fabricate planar NiO x film for PSCs and paved the way for high performance PSCs with CBD-prepared hole transporting materials. | Liqi Li Wenjian Shen Chenquan Yang Yuxi Dou Xuehao Zhu Yao Dong Juan Zhao Junyan Xiao Fuzhi Huang Yi-Bing Cheng Jie Zhong | 2023 | Journal of Materials Science & Technology2023，，2： | 0 |
| 9 | Genome-wide analysis identify novel germline genetic variations in ADCY1 influencing platinum-based chemotherapy response in nonsmall cell lung cancer显示文摘To explore the pharmacogenomic markers that affect the platinum-based chemotherapy response in non-small-cell lung carcinoma(NSCLC),we performed a two-cohort of genome-wide association studies(GWAS),including 34 for WES-based and 433 for microarray-based analyses,as well as two independent validation cohorts.After integrating the results of two studies,the genetic variations related to the platinum-based chemotherapy response were further determined by fine-mapping in 838 samples,and their potential functional impact were investigated by eQTL analysis and in vitro cell experiments.We found that a total of 68 variations were significant at P<1×10^(-3)in cohort 1 discovery stage,of which 3 SNPs were verified in 262 independent samples.A total of541 SNPs were significant at P<1×10^(-4)in cohort 2 discovery stage,of which 8 SNPs were verified in 347 independent samples.Comparing the validated SNPs in two GWAS,ADCY1 gene was verified in both independent studies.The results of fine-mapping showed that the G allele carriers of ADCY1rs2280496 and C allele carriers of rs189178649 were more likely to be resistant to platinum-based chemotherapy.In conclusion,our study found that rs2280496 and rs189178649 in ADCY1 gene were associated the sensitivity of platinum-based chemotherapy in NSCLC patients. | Chenxue Mao Juan Chen Ting Zou Yuankang Zhou Junyan Liu Xi Li Xiangping Li Min Li Pinhua Pan Wei Zhuo Yang Gao Shuo Hu Desheng Xiao Lin Wu Zhan Wang Heng Xu Wen Yang Yingjie Xu Haihua Xiao Kazuhiko Hanada Wei Zhang Honghao Zhou Jiye Yin Zhaoqian Liu | 2022 | Acta Pharmaceutica Sinica B2022，12，3： | 0 |
| 10 | Existing tests vs. novel non-invasive assays for detection of invasive aspergillosis in patients with respiratory diseases显示文摘Background: Although existing mycological tests (bronchoalveolar lavage [BAL] galactomannan [GM], serum GM, serum (1,3)-β-D-glucan [BDG], and fungal culture) are widely used for diagnosing invasive pulmonary aspergillosis (IPA) in non-hematological patients with respiratory diseases, their clinical utility in this large population is actually unclear. We aimed to resolve this clinical uncertainty by evaluating the diagnostic accuracy and utility of existing tests and explore the efficacy of novel sputum-basedAspergillus assays.Methods: Existing tests were assessed in a prospective and consecutive cohort of patients with respiratory diseases in West China Hospital between 2016 and 2019 while novel sputum assays (especially sputum GM andAspergillus-specific lateral-flow device [LFD]) in a case-controlled subcohort. IPA was defined according to the modified European Organization for Research and Treatment of Cancer/Mycoses Study Group criteria. Sensitivity and specificity were computed for each test and receiver operating characteristic (ROC) curve analysis was performed.Results: The entire cohort included 3530 admissions (proven/probable IPA=66, no IPA=3464) and the subcohort included 127 admissions (proven/probable IPA=38, no IPA=89). Sensitivity of BAL GM (≥1.0 optical density index [ODI]: 86% [24/28]) was substantially higher than that of serum GM (≥0.5 ODI: 38% [39/102]) (χ^(2)=19.83,P<0.001), serum BDG (≥70 pg/mL: 33% [31/95]) (χ^(2)=24.65,P<0.001), and fungal culture (33% [84/253]) (χ^(2)=29.38,P<0.001). Specificity varied between BAL GM (≥1.0 ODI: 94% [377/402]), serum GM (≥0.5 ODI: 95% [2130/2248]), BDG (89% [1878/2106]), and culture (98% [4936/5055]). Sputum GM (≥2.0 ODI) had similar sensitivity (84% [32/38]) (Fisher’s exactP=1.000) to and slightly lower specificity (87% [77/89]) (χ^(2)=5.52,P=0.019) than BAL GM (≥1.0 ODI). Area under the ROC curve values were comparable between sputum GM (0.883 [0.812-0.953]) and BAL GM (0.901 [0.824-0.977]) (P=0.734). Sputum LFD had similar specificity (91% [81/89]) (χ^(2)=0.89,P=0.345) to and lower sensitivity (63% [24/38]) (χ^(2)=4.14,P=0.042) than BAL GM (≥1.0 ODI), but significantly higher sensitivity than serum GM (≥0.5 ODI) (χ^(2)=6.95,P=0.008), BDG (χ^(2)=10.43,P=0.001), and fungal culture (χ^(2)=12.70,P<0.001).Conclusions: Serum GM, serum BDG, and fungal culture lack sufficient sensitivity for diagnosing IPA in respiratory patients. Sputum GM and LFD assays hold promise as rapid, sensitive, and non-invasive alternatives to the BAL GM test. | Wei Xiao Longyi Du Linli Cai Tiwei Miao Bing Mao Fuqiang Wen Peter Gerard Gibso Deying Gong Yan Zeng Mei Kang Xinmiao Du Junyan Qu Yan Wang Xuemei Liu Ruizhi Feng Juanjuan Fu | 2022 | Chinese Medical Journal2022，，13： | 0 |
| 11 | Advances of nanoparticles in transmucosal drug delivery显示文摘Transmucosal drug administration represents a potential strategy for enhancing treatment efficacy and reducing side effects by avoiding the first-pass effect into the systemic circulation and delivering therapeutics directly to the target disease site.However,many challenges still remain in its clinical application,including low drug availability and limited retention time in the mucosa.The burgeoning advancement of nanotechnologies offers great potential to overcome the above limitations,leveraging their distinct advantages of high drug-loading capacity and strong permeability.In this review,the latest developments of nanoparticles(NPs)in transmucosal drug delivery as well as their clinical applications are discussed. | Li Zhang Changwei Yang Yingxiang Song Tao Sheng Junyan Li Jicheng Yu Xiaohong Wu Xiao Ye | 2024 | Nano Research2024，17，4： | 0 |
| 12 | The Change of Three Sorts of Herb by Two Kinds of Sterilization Methods显示文摘 | Junyan Tao Zhijun Huang Lei Zhao Xiaoyu Zhang Guangqiong Zhang Fei Xiao Chongming Li | 2006 | Journal of US-China Medical Science2006，3，5： | 0 |
| 13 | A novel method for atomization energy prediction based on natural-parameter network显示文摘Atomization energy(AE)is an important indicator for measuring material stability and reactivity,which refers to the energy change when a polyatomic molecule decomposes into its constituent atoms.Predicting AE based on the structural information of molecules has been a focus of researchers,but existing methods have limitations such as being time-consuming or requiring complex preprocessing and large amounts of training data.Deep learning(DL),a new branch of machine learning(ML),has shown promise in learning internal rules and hierarchical representations of sample data,making it a potential solution for AE prediction.To address this problem,we propose a natural-parameter network(NPN)approach for AE prediction.This method establishes a clearer statistical interpretation of the relationship between the network’s output and the given data.We use the Coulomb matrix(CM)method to represent each compound as a structural information matrix.Furthermore,we also designed an end-to-end predictive model.Experimental results demonstrate that our method achieves excellent performance on the QM7 and BC2P datasets,and the mean absolute error(MAE)obtained on the QM7 test set ranges from 0.2 kcal/mol to 3 kcal/mol.The optimal result of our method is approximately an order of magnitude higher than the accuracy of 3 kcal/mol in published works.Additionally,our approach significantly accelerates the prediction time.Overall,this study presents a promising approach to accelerate the process of predicting structures using DL,and provides a valuable contribution to the field of chemical energy prediction. | Chaoqin Chu Qinkun Xiao Chaozheng He Chen Chen Lu Li Junyan Zhao Jinzhou Zheng Yinhuan Zhang | 2024 | Chinese Chemical Letters2024，35，1： | 0 |
| 14 | Differential regulation of JAK1 expression by ETS1 associated with predisposition to primary biliary cholangitis显示文摘Primary biliary cholangitis(PBC)is an autoimmune liver disease characterized by the destruction of intrahepatic small bile ducts and progressive cholestasis,eventually leading to liver cirrhosis and hepatic failure without appropriate treatment(Terziroli Beretta-Piccoli et al.,2019). | Peng Jiang Chan Wang Mingming Zhang Ye Tian Weifeng Zhao Junyi Xin Yexi Huang Zhibin Zhao Wenjuan Sun Jie Long Ruqi Tang Fang Qiu Xingjuan Shi Yi Zhao Li Zhu Na Dai Lei Liu Xudong Wu Jinshan Nie Bo Jiang Youlin Shao Yueqiu Gao Jianjiang Yu Zhigang Hu Zhidong Zang Yuhua Gong Yaping Dai Lan Wang Ningling Ding Ping Xu Sufang Chen Lu Wang Jing Xu Luyao Zhang Junyan Hong Ruonan Qian Hu Li Xuan Jiang Congwei Chen Wenyan Tian Jian Wu Yuzhang Jiang Chongxu Han Kui Zhang Hong Qiu Li Li Hong Fan Liming Chen Jianqiong Zhang Zhongsheng Sun Xiao Han Zhenhua Dai Erguang Li M.Eric Gershwin Zhexiong Lian Xiong Ma Michael F.Seldin Weichang Chen Meilin Wang Xiangdong Liu | 2023 | Journal of Genetics and Genomics2023，50，10： | 0 |
| 15 | Vitamin A deficiency suppresses CEACAM1 to impair colonic epithelial barrier function via downregulating microbial-derived short-chain fatty acids显示文摘Vitamin A (VA) plays an essential role in modulating both the gut microbiota and gut barrier function.Short-chain fatty acids (SCFAs),as metabolites of the gut microbiota,protect the physiological intestinal barrier;however,they are compromised when VA is deficient.Thus,there is an urgent need to understand how and which SCFAs modulate colonic epithelial barrier integrity in VA deficiency (VAD).Herein,compared with normal VA rats (VAN),at the beginning of pregnancy,we confirmed that the colonic desmosome junction was impaired in the VAD group,and the amounts of acetate,propionate,and butyrate declined because of the decreased abundance of SCFA-producing bacteria (Romboutsia ,Collinsella ,and Allobaculum ).The differentially expressed genes correlated with the gut barrier and the histone deacetylase complex between the VAD and VAN groups were enriched by RNA sequencing.In the VAD group,the expression levels of colonic CEA cell adhesion molecule 1 (CEACAM1) were down-regulated,and the levels of histone deacetylase 1 (HDAC1) and HDAC3 were up-regulated.Intriguingly,the above changes in the VAD groups were rescued by VA supplementation in the early postnatal period.Further study indicated that in Caco-2 cells,butyrate treatment significantly repressed the enrichment of HDAC3 on the promoter of the CEACAM1 gene to induce its expression.Our findings support that butyrate intervention can alleviate the impairment of colonic barrier function caused by VAD,and timely postnatal VA intervention may reverse the damage caused by VAD on gut barrier integrity during pregnancy. | Junyan Yan Lu Xiao Di Feng Baolin Chen Ting Yang Bei Tong Ruifang Luo Yuting Wang Jie Chen | 2024 | Genes & Diseases2024，11，2： | 0 |
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