|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Prognostic value of programmed death.1, programmed death-ligand 1, programmed death-ligand 2 expression, and CD8(+) T cell density in primary tumors and metastatic lymph nodes from patients with stage T1.4N+M0 gastric adenocarcinoma显示文摘Background: Anti-programmed death-1/programmed death-ligand 1(PD-1/PD-L1) immunotherapy has been proved to be effective on gastric cancer in ongoing clinical trials. However, the value of PD-L1 in predicting responses of patients with gastric cancer to anti-PD-1/PD-L1 immunotherapy is controversial. Some studies suggested that intra-and inter-tumoral heterogeneity of PD-L1 expression might explain the controversy.This study aimed to analyze the expression of PD-L1, PD-L2, and PD-1 as well as CD8(+) T-cell density in primary tumors and lymph nodes from patients with stage T1-4 N+M0 gastric adenocarcinoma to explore the heterogeneity of PD-1 signaling pathway molecules.Methods: In primary tumors and metastatic as well as non-metastatic lymph nodes from patients with stage T1-4 N+M0 gastric adenocarcinoma, we detected PD-L1 and PD-L2 expression with immunohistochemistry. CD8(+)T-cell density in primary tumors and PD-1 expression on CD8(+)T cells were detected with immunofluorescence. Univariate analysis was used to determine the prognostic values of them. Cox proportional hazard regression model was used to identify independent risk factors that affect patients' overall survival and disease-free survival.Results: Among 119 eligible patients who had undergone surgical resection, the positive rate of PD-L1 was higher in metastatic lymph nodes than in primary tumors(45.4% vs. 38.7%, P = 0.005); the positive rate of PD-1 on CD8(+)T cells was significantly higher in primary tumors and metastatic lymph nodes than in tumor-free lymph nodes(both P < 0.001). The intensity of PD-1 expression on CD8(+) T cells in primary tumors and in metastatic lymph nodes were stronger than that in tumor-free lymph nodes from the same patient. Beside, the positive rate of PD-L2 did not show any differences between primary tumors and metastatic lymph nodes. In multivariate analysis, PD-L1 expression,PD-L2 expression, a low density of CD8(+) T cells in primary tumors, and PD-1 expression on CD8(+) T cells in primary tumors were associated with poor prognosis.Conclusion: The expression of PD-L1 is heterogeneous in primary tumors and in metastatic lymph nodes from patients with stageT1-4 N+M0 gastric adenocarcinoma, which might explain the inconsistent results in assessing the prognostic value of PD-L1 expression in previous studies. | Yuan Gao Su Li Dazhi Xu Shangxiang Chen Yuchen Cai Wenqi Jiang Xinke Zhang Jin Sun Kefeng Wang Boyang Chang Fenghua Wang Minghuang Hong | 2017 | Chinese Journal of Cancer2017，36，11： | 8 |
| 2 | Preparation and crystallization kinetics of micron-sized Mg(OH)2 in a mixed suspension mixed product removal crystallizer显示文摘镁氢氧化物是重要化学药品,并且通常经由降水过程从海水或盐水被获得。镁氢氧化物的粒子尺寸分发在随后的过滤上有大效果,弄干处理。在这份报纸,有高纯净的微米大小的镁氢氧化物,大粒子尺寸和低水,在过滤器蛋糕的内容在混合暂停经由简单湿降水被综合混合产品移动(MSMPR ) crystallizer。镁氢氧化物的性质上的反应物集中,住处时间和杂质的效果被 X 光检查衍射(XRD ) 调查,扫描电子显微镜学(SEM ) 和 Malvern 激光粒子尺寸分析器。结果证明 NaOH 集中和住处时间在水内容和 Mg 的粒子尺寸上有大效果(哦) 2。球形的 Mg (哦) 2 与比 99% 高的纯净和水内容与大约 30 m 的一致直径被获得不到 31% 。而且,结晶化动力学基于人口平衡理论被学习基于 ASL 模型为工业增大,和模拟系数( R 2 )提供理论数据,分别地, C-R 模型是 0.9962 和 0.9972 显示镁氢氧化物的水晶生长率能好由 sizedependent 生长模型模仿了。 | Xingfu SONG Kefeng TONG Shuying SUN Ze SUN Jianguo YU | 2013 | Frontiers of Chemical Science and Engineering2013，7，2： | 7 |
| 3 | Sensitivity Experiments on the Poleward Shift of Tropical Cyclones over the Western North Pacific under Warming Ocean Conditions显示文摘Recent studies found that in the context of global warming, the observed tropical cyclones(TCs) exhibit significant poleward migration trend in terms of the mean latitude where TCs reach their lifetime-maximum intensity in the western North Pacific(WNP). This poleward migration of TC tracks can be attributed to not only anthropogenic forcing(e.g., continuous increase of sea surface temperature(SST)), but also impacts of other factors(e.g., natural variability). In the present study, to eliminate the impacts of other factors and thus focus on the impact of unvaried SST on climatological WNP TC tracks, the mesoscale Weather Research and Forecasting(WRF) model is used to conduct a suite of idealized sensitivity experiments with increased SST. Comparisons among the results of these experiments show the possible changes in climatological TC track, TC track density, and types of TC track in the context of SST increase. The results demonstrate that under the warmer SST conditions, the climatological mean TC track systematically shifts poleward significantly in the WNP, which is consistent with the previous studies. Meanwhile, the ocean warming also leads to the decreased(increased) destructive potential of TCs in low(middle) latitudes, and thus northward migration of the region where TCs have the largest impact. Further results imply the possibility that under the ocean warming, the percentage of TCs with westward/northwestward tracks decreases/increases distinctly. | Yixuan SHEN Yuan SUN Zhong ZHONG Kefeng LIU Jian SHI | 2018 | Journal of Meteorological Research2018，32，4： | 3 |
| 4 | A Multifunctional Anti-Proton Electrolyte for High-Rate and Super-Stable Aqueous Zn-Vanadium Oxide Battery显示文摘Large volumetric expansion of cathode hosts and sluggish transport kinetics in the cathode–electrolyte interface,as well as dendrite growth and hydrogen evolution at Zn anode side are considered as the system problems that cause the electrochemical failure of aqueous Zn-vanadium oxide battery.In this work,a multifunctional anti-proton electrolyte was proposed to synchronously solve all those issues.Theoretical and experimental studies confirm that PEG 400 additive can regulate the Zn^(2+) solvation structure and inhibit the ionization of free water molecules of the electrolyte.Then,smaller lattice expansion of vanadium oxide hosts and less associated by-product formation can be realized by using such electrolyte.Besides,such electrolyte is also beneficial to guide the uniform Zn deposition and suppress the side reaction of hydrogen evolution.Owing to the integrated synergetic modifica-tion,a high-rate and ultrastable aqueous Zn-V_(2)O_(3)/C battery can be constructed,which can remain a specific capacity of 222.8 m Ah g^(-1)after 6000 cycles at 5 A g^(-1),and 121.8 m Ah g^(-1) even after 18,000 cycles at 20 A g^(-1),respectively.Such“all-in-one”solution based on the electrolyte design provides a new strategy for developing high-performance aqueous Zn-ion battery. | Yangwu Chen Dingtao Ma Kefeng Ouyang Ming Yang Sicheng Shen Yanyi Wang Hongwei Mi Lingna Sun Chuanxin He Peixin Zhang | 2022 | Nano-Micro Letters2022，14，9： | 3 |
| 5 | Impact of Initial Storm Intensity and Size on the Simulation of Tropical Cyclone Track and Western Pacific Subtropical High Extent显示文摘Typhoon Megi, the 13 th typhoon of the 2010 typhoon season, was selected for case study by utilizing the Weather Research and Forecasting(WRF) model. Twelve sensitivity experiments with various initial tropical cyclone(TC) intensities and sizes were conducted to investigate their impacts on the simulation of typhoon track. Interaction between TC and the western Pacific subtropical high(WPSH) was also analyzed to explore the mechanism for the impact on TC track of the initial TC intensity and size. Numerical results indicate that the simulated TC size and TC track are sensitive to initial TC intensity and size. Stronger initial TC intensity and larger initial TC size often lead to larger simulated TC size and make TC turn northward earlier. Further analysis suggests that, with the increase of initial TC intensity and size, more air mass enters into the TC region, which subsequently reduces the extent of WPSH.As a result, the steering flow changes significantly and eventually causes the TC to turn northward earlier. The present study confirms that the initial TC intensity and size have certain influences on the TC track simulation, which demonstrates the importance of accurate initial condition for successful simulation of the TC intensity and TC track.Moreover, it also deepens our understanding of the interaction between TC and WPSH, provides helpful clues for the TC track change study, and discusses the future directions for improvement of TC track forecast. | Yuxing WANG Yuan SUN Qianfeng LIAO Zhong ZHONG Yijia HU Kefeng LIU | 2017 | Journal of Meteorological Research2017，31，5： | 2 |
| 6 | Dynamics Analysis for Generic Projection Continuous-Time RNNs with Bounded Matrices显示文摘The dynamics analysis of recurrent neural networks(RNNs)is a first and necessary step for any practical applications of them.In the present paper,the easily verified theorem is found to ascertain the asymptotical stability for generic RNN model with projection mapping under the critical condition that a discriminant matrix defined by the networks is semi-positive definite.The results given here not only improve deeply upon the existing relevant critical as well as non-critical dynamics conclusions in literature,but also can be used in the practical application of RNNs directly. | QIAO Chen LIANG Dong SUN Kefeng | 2015 | Journal of Systems Science & Complexity2015，28，4： | 2 |
| 7 | Local sparsity divergence for hyperspectral anomaly detection显示文摘 | Yuan Zongze Sun Hao Ji Kefeng | 2014 | IEEEGeoscience and Remote Sensing Letters2014，11，10： | 1 |
| 8 | Construction of redox-active multilayer film for electrochemically con- trolled release 显示文摘 | SUN Yixin REN Kefeng ZHAO Yixiu | 2013 | Langmuir2013，29，11： | 1 |
| 9 | Local Sparsity Divergence for Hyperspectral Anomaly Detection 显示文摘 | YUAN Zongze SUN Hao J | 2014 | IEEE Geoseienee & Remote SensingLetters(S1545-598X)2014，11，10： | 1 |
| 10 | Junction plakoglobin regulates and destabilizes HIF2α to inhibit tumorigenesis of renal cell carcinoma显示文摘Background:Increased hypoxia-inducible factor 2α(HIF2α)activation is a common event in clear cell renal cell carcinoma(ccRCC)progression.However,the function and underlying mechanism of HIF2α in ccRCC remains uninvestigated.We conducted this study to access the potential link between junction plakoglobin(JUP)and HIF2αin ccRCC.Methods:Affinity purification and mass spectrometry(AP-MS)screening,glutathione-s-transferase(GST)pull-down and co-immunoprecipitation(Co-IP)assays were performed to detect the interacting proteins of HIF2α.Quantitative PCR(qPCR)and Western blotting were used to detect the expression of JUP in human ccRCC samples.Luciferase reporter assays,chromatin immunoprecipitation(ChIP),cycloheximide chase assays,and ubiquitination assays were conducted to explore the regulation of JUP on the activity of HIF2α.Cell Counting Kit-8(CCK-8)assays,colony formation assays,transwell assays,and xenograft tumor assays were performed to investigate the effect of JUP knockdown or overexpression on the tumorigenicity of renal cancer cells.Results:We identified JUP as a novel HIF2α-binding partner and revealed an important role of JUP in recruiting von Hippel-Lindau(VHL)and histone deacetylases 1/2(HDAC1/2)to HIF2α to regulate its stability and transactivation.JUP knockdown promoted and overexpression suppressed the tumorigenicity of renal cell carcinoma in vitro and in vivo.Importantly,the low expression of JUP was found in clinical ccRCC samples and correlated with enhanced hypoxia scores and poor treatment outcomes.Conclusion:Taken together,these data support a role of JUP in modulating HIF2α signaling during ccRCC progression and identify JUP as a potential therapeutic target. | Ke Chen Jin Zeng Yi Sun Wei Ouyang Gan Yu Hui Zhou Yangjun Zhang Weimin Yao Wei Xiao Junhui Hu Jinchun Xing Kefeng Xiao Lily Wu Zhiqiang Chen Zhangqun Ye Hua Xu | 2021 | Cancer Communications2021，41，4： | 1 |
| 11 | Research on processing medicinal herbs with multi-steps infrared macrofingerprint method 显示文摘 | Yu Lu Sun Suqin Fan Kefeng | 2005 | Spectrochim Acta A2005，62，13： | 1 |
| 12 | Simulation of nitrogen fate for greenhouse cucumber grown under different water and fertilizer management using the EU-Rotate- N model 显示文摘 | SUN Yuan HU Kelin ZHANG Kefeng | 2012 | Agricultural Water Management2012，112，： | 1 |
| 13 | Research on the Contents of Chinese Seabucklthorn Fruit Oil and Its Application to Chloasma Treatments显示文摘 | Hanqing Xu Junfeng Ren Huili Xu Kefeng Sun Ailin Lv Jie Fen | 2005 | Journal of US-China Medical Science2005，2，6： | 1 |
| 14 | Chromium(III) complexes bearing 2-benzazole-1,10-phenanthrolines : Synthesis, molecular structures and ethylene oligomerization and polymerization显示文摘 | Zhang Min Wang Kefeng Sun Wenhua | 2009 | Dalton Transactions2009，32，： | 1 |
| 15 | Research on processingmedicinal herbs with multi-steps infraredmacro-ngerprint meth-od显示文摘 | Yu Lu Sun Suqin Fan Kefeng | 2005 | Spectrochim Acta A Mol Biomol Spectrosc2005，62，13： | 1 |
| 16 | Circular RNA: A new star of noncoding RNAs显示文摘 | Shibin Qu Xisheng Yang Xiaolei Li Jianlin Wang Yuan Gao Runze Shang Wei Sun Kefeng Dou Haimin Li | 2015 | Cancer Letters2015，，2： | 1 |
| 17 | Corrigendum to“Bioinspired supramolecular nanofiber hydrogel through self-assembly of biphenyl-tripeptide for tissue engineering”[Bioact.Mater.8(2022)396-408]显示文摘The authors regret that the published version of the above article contained error in Fig.6F,which was not identified during the proofing stage.The wrong live/dead stain,F-actin stain,and SEM images of BPAA-GFF gel were selected during the assembly of Fig.6F.The images of Fig.6F have been replaced with the correct images as follow.The authors apologize for this error and state that the figure’s correction did not change the scientific conclusions of the article in any way. | Yong Sun Xing Li Mingda Zhao Yafang Chen Yang Xu Kefeng Wang Shaoquan Bian Qing Jiang Yujiang Fan Xingdong Zhang | 2023 | Bioactive Materials2023，，5： | 0 |
| 18 | Numerical Study of Convective and Radiation Heat Transfer Characteristics in an Upward-Facing Cylindrical Cavity under Back-Side Windy Condition显示文摘Under the back-side windy condition,the convection and radiation heat transfer characteristics in an iso-flux upward-facing cylindrical cavity were studied by three-dimensional numerical simulation.The impacts of cavity tilt angle,wind incident angle and wind speed on convection and radiation heat transfer Nusselt number Nuc and Nur were analyzed,and the possible explanations for their impacts were presented.Results show that due to the disturbance of wind,the influence of cavity tilt angle becomes more complicated and is related to wind incident angle and wind speed.The variation of Nuc or Nur with wind incident angle is different for different cavity tilt angles.Despite of the changes of cavity tilt angle or wind incident angle,the Nuc increases with the wind speed while the Nur presents a declination with the increasing of wind speed.Hence,compared with cavity tilt angle and wind incident angle,wind speed may be the dominant factor affecting or controlling the convective and radiation heat transfer of cavity. | WANG Zehui WU Kefeng WANG Ti XIA Liangwei YU Qiang HUANG Ying SUN Hao WEI Guohua GUAN Jingyu YAN Yanfei | 2021 | Journal of Thermal Science2021，30，1： | 0 |
| 19 | Biofabrication (3D Bioprinting) Laboratory at Sichuan University显示文摘Introduction and research overview Recently,increasing need for organ transplantation and lack of donated organs have led to the rapid development of new technologies for artificial organ biofabrication.In the era of burgeoning breakthroughs around 3D bioprinting technologies,the personalization of organs and medicine is an ongoing nice vision[1–5].As one of the leading laboratories in the interdisciplinary field of materials,manufacturing and bioengineering,the Biofabrication(3D Bioprinting)Research Laboratory at Sichuan University has been engaging in the research on customized regenerativemedicine since 2012. | Changchun Zhou Kefeng Wang Yong Sun Qiguang Wang Qing Jiang Jie Liang Xuan Pei Boqing Zhang Yujiang Fan Xingdong Zhang | 2021 | Bio-Design and Manufacturing2021，4，2： | 0 |
| 20 | Tolerance and acceptance of hepatic venous pressure gradient measurement in cirrhosis(CHESS1904):An international multicenter study显示文摘Aim:To determine the tolerance and acceptance of hepatic venous pressure gradient(HVPG)measurements in patients with liver cirrhosis.Methods:This prospective international multicenter study included 271 patients with cirrhosis who were scheduled to undergo HVPG measurement between October 2019 and June 2020.Data related to the tolerance and acceptance of HVPG measurements were collected using descriptive questionnaires.Results:HVPG measurements were technically successful in all 271 patients,with 141(52.0%)undergoing HVPG measurement alone.The complication rate was 0.4%.Postoperative pain was significantly lower than preoperative expected pain(p<0.001)and intraoperative pain(p<0.001),and intraoperative pain was also significantly lower than preoperative expected pain(p=0.036).No,mild,moderate,severe,and intolerable discomfort scores were reported by 36.9%,44.6%,11.1%,6.3%,and 0.4%of these patients,respectively,during HVPG measurement and by 54.6%32.5%,11.4%,1.5%,and 0%,respectively,after HVPG measurement.Of these patients,39.5%had little understanding and 10%had no understanding of the value of HVPG measurement,with 35.1%and 4.1%regarding HVPG measurements as being of little or no help,respectively.Most patients reported that they would definitely(15.5%),probably(46.9%),or possibly(29.9%)choose to undergo additional HVPG measurements again,and 62.7%regarded the cost of the procedure as acceptable.Conclusion:HVPG measurement was safe and well‐tolerated in patients with cirrhosis,but patient education and communication are warranted to improve the acceptance of this procedure. | Jun‐Hui Sun He Zhao Haijun Zhang Lei Li NecatiÖrmeci Zi‐Niu Yu Xun Li Shuangxi Li Xujun Yang Huaping Wei Xiaoliang Zhu Zhengcong Zhang Yajin Wang Zhongwei Zhao Jianting Mao Qiaohong Wu Xiaole Sun Huiling Xiang Kefeng Jia Chao Yang Wei Wu Xiuqing Lin Haixin Yao Changzeng Zuo Jitao Wang Bo Zhang Chunqing Zhang Xiaoling Wu Guangchuan Wang Shengjuan Yao Ruihang Wang Li Zhou Hui Huan Qingli Tu Xue Pu Feng Zhang Qin Yin Linpeng Zhang Ying Guo Jian Wang Kohei Kotani Sawako Uchida‐Kobayashi Norifumi Kawada He Zhu Li Li Wei Wang Guo Zhang Lei Yu Xudong Cui Qingliang Zhu Hailong Zhang Xiaoli Hu Rafael OXimenes Adriano Gonçalves de Araújo Giulliano Gardenghi Yubao Zheng Zebin Wu Mingsheng Huang Xiaoyong Chen Jun Wu Feng Xie Yang Bo Shengjuan Hu Linke Ma Xiao Li Xiaolong Qi | 2022 | Portal Hypertension & Cirrhosis2022，1，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员