|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Mushroom Poisoning Outbreaks—China,2010–2020显示文摘ABSTRACT Introduction:Mushroom poisoning was the leading cause of foodborne disease outbreaks and outbreak-associated deaths in China.Mushroom poisoning outbreak surveillance can provide insight into the epidemiological characteristics of mushroom poisonings and guide policymaking and health education to reduce illnesses and deaths.Methods:Foodborne Disease Outbreak Surveillance System was upgraded in 2011 to collect foodborne disease outbreaks in China.Mushroom poisoning outbreaks during 2010–2020 were selected to analyze geographical distribution,seasonal distribution,and setting of food preparation.Results:A total of 10,036 outbreaks,which resulted in 38,676 illnesses and 788 deaths,were reported in this period.Mushroom poisonings occurred all over the country,but with highest incidence in the southwest and central China. | Weiwei Li Sara M.Pires Zhitao Liu Jinjun Liang Yafang Wang Wen Chen Chengwei Liu Jikai Liu Haihong Han Ping Fu Yunchang Guo | 2021 | China CDC weekly2021，3，24： | 18 |
| 2 | Prospect of the QTL-qSB-9^(Tq) utilized in molecular breeding program of japonica rice against sheath blight显示文摘The major QTL-qSB-9Tq conferring partial resistance to rice (Oryza sativa L.) sheath blight (Rhizoctonia solani Kühn) has been verified on chromosome 9 of the indica rice cultivar, Teqing. In this study, the prospect of this QTL utilized in molecular breeding program of japonica rice for sheath blight resistance was investigated. Most of the japonica rice cultivars showed lower level of sheath blight resistance than the indica rice cultivars. At the corresponding site of qSB-9Tq, nine typical japonica rice cultivars from different ecological regions or countries proved to possess the susceptible allele(s). Introgression of qSB-9Tq into these cultivars enhanced their resistance level by decreasing sheath blight score of 1.0 (0.5–1.3), which indicated that qSB-9Tq had a large potential in strengthening the resistance of japonica rice to sheath blight. The use of the three molecular markers, which were polymorphic between Teqing and many japonica rice cultivars, promotes the application of qSB-9Tq in a concrete molecular breeding program. | Shimin Zuo Li Zhang Hui Wang Yuejun Yin Yafang Zhang Zongxiang Chen Yuyin Ma Xuebiao Pan | 2008 | Journal of Genetics and Genomics2008，35，8： | 14 |
| 3 | Fine mapping of an incom-plete recessive gene for leaf rolling in rice (Oryza sativa L.)显示文摘Genetic analysis and fine mapping of genes controlling leaf rolling were conducted using two back-crossed generations (BC4F2, BC4F3) derived from a cross between QMX, a non-rolled leaf cultivar as a recurrent par-ent, and JZB, a rolled leaf NIL of ZB as a donor parent. Re-sults indicated that leaf rolling was mainly controlled by an incompletely recessive major gene, namely rl(t), and at the same time, affected by quantitative trait loci (QTLs) and/or the environment. A genetic linkage map was constructed using MAPMAKER/EXP3.0 with eight polymorphic mark-ers on chromosome 2, which were screened by BAS method from 500 SSR markers and 15 newly developed inser-tion/deletion (InDel) markers. The position of rl(t) was esti-mated with composite interval mapping (CIM) method using WinQTLcart2.5. Gene rl(t) was mapped between markers InDel 112 and RM3763, and 1.0 cM away from InDel 112 using 241 plants in BC4F2 population. To fine map rl(t), one BC4F3 line with 855 plants was generated from one semi-rolled leaf plant in BC4F2. Four new polymorphic InDel markers were developed, including InDel 112.6 and InDel 113 located between markers InDel112 and RM3763. Based on the information of recombination offered by 191 rolled leaf plants and 185 non-rolled leaf plants from the BC4F3 line ,we mapped rl(t) to a 137-kb region between markers InDel 112.6 and InDel 113. Homologous gene analysis sug-gested that rl(t) was probably related to the process of leaf development regulated by microRNA. | SHAO Yuanjia PAN Cunhong CHEN Zongxiang ZUO Shimin ZHANG Yafang PAN Xuebiao | 2005 | Chinese Science Bulletin2005，50，21： | 13 |
| 4 | microRNA-29b is a novel mediator of Sox2 function in the regulation of somatic cell reprogramming显示文摘成纤维细胞能由 Yamanaka 因素(OSKM ) 的申请是进导致的 pluripotent 干细胞(iPSCs ) 的 reprogrammed,但是位于这 reprogramming 下面的机制仍然保持糟糕理解。这里,我们报导 Sox2 直接调整内长的 microRNA-29b (miR-29b ) 表示为调停 OSKM 、调停 OSK 的 reprogramming 在 iPSC 产生和那 miR-29b 表情期间被要求。Dnmt3a 和 Dnmt3b 在 miR-29b 和那 Dnmt3a 和 Dnmt3b 表示的 vivo 目标的机械学的研究表演相反地在 reprogramming 期间与 miR-29b 表示被相关。而且, reprogramming 上的 miR-29b 的效果能被 Dnmt3a 或 Dnmt3b overexpression 堵住。进一步的实验显示发信号的 miR-29b-DNMT 显著地涉及 DNA methylation 相关的 reprogramming 事件的规定,例如 mesenchymal-to-epithelial 转变(相遇) 并且 Dlk1-Dio3 区域抄写。因此,我们的研究不仅表明 miR-29b 是 reprogramming 因素 Sox2 的一个新奇调停人而且为 Sox2 在驾驶表明调整 DNA 的轴的 miR-29b-DNMT 的 multistep 机制提供证据 methylation 相关的事件在 reprogramming 期间。 | Xudong Guo Qidong Liu Guiying Wang Songcheng Zhu Longfei Gao Wujun Hong Yafang Chen Minjuan Wu Houqi Liu Cizhong Jiang Jiuhong Kang | 2013 | Cell Research2013，23，1： | 9 |
| 5 | ELASTIC WAVE LOCALIZATION IN TWO-DIMENSIONAL PHONONIC CRYSTALS WITH ONE-DIMENSIONAL QUASI-PERIODICITY AND RANDOM DISORDER显示文摘在里面飞机并且反飞机橡皮波浪宣传在的乐队结构二维订并且混乱(在一个方向) phononic 晶体在这份报纸被学习。波浪繁殖的本地化被介绍由 plane-wave-based 转移矩阵方法是计算的本地化因素的概念由于随机的混乱讨论。由以一个特殊方法从频率把伪频率当作偏差,在另外的方向在一个方向和翻译对称有伪频率(Fibonacci 顺序) 的二种伪 phononic 水晶被考虑,乐队结构被使用本地化因素描绘。结果证明本地化因素是在描绘二维的完美、随机混乱、伪周期的 phononic 晶体的乐队差距的一个有效参数。phononic 晶体的乐队结构能被不同随机的混乱调节或改变伪周期的参数。伪 phononic 晶体比的与更狭窄的宽度展出更多的乐队差距订并且随机混乱的系统。 | Ali Chen Yuesheng Wang Guilan Yu Yafang Guo Zhengdao Wang | 2008 | Acta Mechanica Solida Sinica2008，21，6： | 8 |
| 6 | Isolation and characterization of rl_(t), a gene that controls leaf rolling in rice显示文摘Moderate leaf rolling is one of the most important morphological traits in rice breeding for plant ideotype.Previous studies have shown that the rl(t)gene has a high breeding potential for developing hybrid-rice varieties with an ideal ideotype,because it leads to an appropriate leaf rolling index(LRI)of about 30%in the heterozygous state,and had a positive effect on grain yield.In this study,we isolated rl(t)and performed a preliminary investigation of its function in regulating leaf rolling in rice.DNA sequencing identified a single base change(G to T)in the finely mapped region(11 kb)containing rl(t),and this is located in 30-untranslated region(30-UTR)of the only predicted gene,Roc5(Rice outermost cell-specific).The expression level of Roc5 is significantly higher in the rl(t)mutant than in the wild-type.Using RNAi and overexpression analysis,we found that the expression level of Roc5 correlated with LRI and leaf bulliform area,and wasalso associated with leaf abaxial or adaxial rolling.These results confirmed that Roc5 controls leaf rolling in a dosage-dependent manner.Bioinformatics analysis revealed a conserved 17-nt sequence(called the GU-rich element)in the 30-UTR of HD-GL2(Homeodomain-Glabra2)family genes including Roc5.Based on the model of this element in regulating mRNA stability in mammals,we speculate that the single nucleotide change in this element accounts for the higher expression level of Roc5 in the rl(t)mutant compared to the wild-type,which ultimately leads to adaxial rolling of the leaf.This discovery further enhances our knowledge of the molecular mechanisms underlying leaf rolling in rice. | Lei Li Xiang Xue Zongxiang Chen Yafang Zhang Yuyin Ma Cunhong Pan Junkai Zhu Xuebiao Pan Shimin Zuo | 2014 | Chinese Science Bulletin2014，59，25： | 4 |
| 7 | Synthesis of gold/rare-earth-vanadate core/shell nanorods for integrating plasmon resonance and fluorescence显示文摘nanoscale 核心 / 壳 heterostructure 是一个特别地有效的主题联合 plasmonic 材料和稀土元素的混合物的有希望的性质;然而,在那里由于在这二内在地无敌的材料之间的大界面的精力在合成控制仍然是重要挑战。此处,我们报导种 rare-earth-vanadate 的一条合成线路在金 nanorod (AuNR ) 上轰炸核心。在通过表面活化剂交换与油酸盐修改 AuNR 表面以后,包装得好的稀土元素的氧化物(例如, Gd 2 O 3:Eu) 壳由于油酸盐的多重角色在 AuNRs 上被种。而且,壳的作文从氧化物被改变了到 vanadate (用一个阴离子交换方法的 GdVO 4:Eu) 。由于小心地设计的策略, AuNR 核心在合成过程期间维持形态学;因此,最后的 Au/GdVO 4:Eu 核心 / 壳 NR 展出强壮的吸收乐队和高 photothermal 效率。另外, Au/GdVO 4:Eu NR 象 ~ 一样高与量产量展出明亮的 Eu 3+ 荧光 17% ;明亮的 Sm 3+ 和 Dy 3+ 荧光能被改变在氧化物形成做的 lanthanide 也获得。由于 plasmonic 和荧光性质的吸引人的集成,如此的核心 / 壳 heterostructures 将在区域的一个宽数组发现特别应用,从 biomedicine 到精力。 | Jiahong Wang Hao Huang Daquan Zhang Ming Chen Yafang Zhang Xuefeng Yu Li Zhou Ququan wang | 2015 | Nano Research2015，8，8： | 4 |
| 8 | Dynamic mechanical loading facilitated chondrogenic differentiation of rabbit BMSCs in collagen scaffolds显示文摘Mechanical signals have been played close attention to regulate chondrogenic differentiation of bone marrow mesenchymal stem cells(BMSCs).In this study,dynamic mechanical loading simulation with natural frequencies and intensities were applied to the 3D cultured BMSCs–collagen scaffold constructs.We investigated the effects of dynamic mechanical loading on cell adhesion,uniform distribution,proliferation,secretion of extracellular matrix(ECM)and chondrogenic differentiation of BMSCs–collagen scaffold constructs.The results indicated that dynamic mechanical loading facilitated the BMSCs adhesion,uniform distribution,proliferation and secretion of ECM with a slight contraction,which significantly improved the mechanical strength of the BMSCs–collagen scaffold constructs for better mimicking the structure and function of a native cartilage.Gene expression results indicated that dynamic mechanical loading contributed to the chondrogenic differentiation of BMSCs with higher levels of AGG,COL2A1 and SOX9 genes,and prevented of hypertrophic process with lower levels of COL10A1,and reduced the possibility of fibrocartilage formation due to down-regulated COL1A2.In conclusion,this study emphasized the important role of dynamic mechanical loading on promoting BMSCs chondrogenic differentiation and maintaining the cartilage phenotype for in vitro reconstruction of tissue-engineered cartilage,which provided an attractive prospect and a feasibility strategy for cartilage repair. | Wanxu Cao Weimin Lin Hanxu Cai Yafang Chen Yi Man Jie Liang Qiguang Wang Yong Sun Yujiang Fan Xingdong Zhang | 2019 | Regenerative Biomaterials2019，6，2： | 3 |
| 9 | Electroacupuncture relieves irritable bowel syndrome by increasing expression of nucleotide-binding oligomerization domain protein-like receptor family pyrin domain containing 6 in water-avoidance stress mice显示文摘OBJECTIVE: To investigate the effect of electroacupuncture(EA) on irritable bowel syndrome(IBS) in mice through regulating nucleotide-binding oligomerization domain protein-like receptor family pyrin domain containing 6(NLRP6).METHODS: Water-avoidance stress(WAS) mice model was used to investigate the effects and the mechanism of EA. Abdominal withdrawal reflex test, open field test, and intestinal motility test were used to evaluate visceral sensitivity, anxiety,and intestinal motility in mice. The expressions of NLRP6, Mucin-2(MUC2) and E-cadherin were determined using immunofluorescence and Western blotting assays.RESULTS: EA significantly upregulated the expression of NLRP6 in the intestine of mice. Moreover, EA increased the expressions of MUC2 and E-cadherin in WAS mice.CONCLUSION: Our study found that the relief of IBS symptoms by EA may involve the increase in the expression of NLRP6 in WAS mice. | Song Yafang Geng Hao Chen Lu Wu Xiaoliang Yuan Mengqian Xu Wanli Guo Jing Sun Jianhua Pei Lixia | 2020 | Journal of Traditional Chinese Medicine2020，40，3： | 3 |
| 10 | Identification of New Resistance Loci Against Sheath Blight Disease in Rice Through Genome-Wide Association Study显示文摘Sheath blight(SB) caused by the soil borne pathogen Rhizoctonia solani is one of the most serious global rice diseases. Breeding resistant cultivar is the most economical and effective strategy to control the disease. However, no rice varieties are completely resistant to SB, and only a few reliable quantitative trait loci(QTLs) linked with SB resistance have been identified to date. In this study, we conducted a genome-wide association study(GWAS) of SB resistance using 299 varieties from the rice diversity panel 1(RDP1) that were genotyped using 44 000 high-density single nucleotide polymorphism(SNP) markers. Through artificial inoculation, we found that only 36.5% of the tested varieties displayed resistance or moderate resistance to SB. In particular, the aromatic and aus sub-populations displayed higher SB resistance than the tropical japonica(TRJ), indica and temperate japonica sub-populations. Seven varieties showed similar resistance levels to the resistant control YSBR1. GWAS identified at least 11 SNP loci significantly associated with SB resistance in the three independent trials, leading to the identification of two reliable QTLs, qSB-3 and qSB-6, on chromosomes 3 and 6. Using favorable alleles or haplotypes of significantly associated SNP loci, we estimated that both QTLs had obvious effects on reducing SB disease severity and can be used for enhancing SB resistance, especially in improving SB resistance of TRJ sub-population rice varieties. These results provided important information and genetic materials for developing SB resistant varieties through breeding. | CHEN Zongxiang FENG Zhiming KANG Houxiang ZHAO Jianhua CHEN Tianxiao LI Qianqian GONG Hongbing ZHANG Yafang CHEN Xijun PAN Xuebiao LIU Wende WANG Guoliang ZUO Shimin | 2019 | Rice science2019，26，1： | 3 |
| 11 | Incomplete lineage sorting and introgression in the diversification of Chinese spot-billed ducks and mallards显示文摘Incomplete lineage sorting and introgression are 2 major and nonexclusive causes of specieslevel non-monophyly.Distinguishing between these 2 processes is notoriously difficult because they can generate similar genetic signatures.Previous studies have suggested that 2 closely related duck species,the Chinese spot-billed duck Anas zonorhyncha and the mallard A.platyrhynchosvjere polyphyletically intermixed.Here,we utilized a wide geographical sampling,multilocus data and a coalescent-based model to revisit this system.Our study confirms the finding that Chinese spot-billed ducks and Mallards are not monophyletic.There was no apparent interspecific differentiation across loci except those at the mitochondrial DNA(mtDNA)control region and the Z chromosome(CHD1Z).Based on an isolation-with-migration model and the geographical distribution of lineages,we suggest that both introgression and incomplete lineage sorting might contribute to the observed non-monophyly of the 2 closely related duck species.The mtDNA introgression was asymmetric,with high gene flow from Chinese spot-billed ducks to Mallards and negligible gene flow in the opposite direction.Given that the 2 duck species are phenotypically distinctive but weakly genetically differentiated,future work based on genomescale data is necessary to uncover genomic regions that are involved in divergence,and this work may provide further insights into the evolutionary histories of the 2 species and other waterfowls. | Wenjuan WANG Yafang WANG Fumin Lei Yang LIU Haitao WANG Jiakuan Chen | 2019 | Current Zoology2019，65，5： | 2 |
| 12 | Transcriptomic Response to Yersinia pestis:RIG-I Like Receptor Signaling Response Is Detrimental to the Host against Plague显示文摘Bacterial pathogens have evolved various mechanisms to modulate host immune responses for successful infection.In this study,RNAsequencing technology was used to analyze the responses of human monocytes THP1 to Yersinia pestis infection.Over 6000 genes were differentially expressed over the 12 h infection.Kinetic responses of pathogen recognition receptor signaling pathways,apoptosis,antigen processing,and presentation pathway and coagulation system were analyzed in detail.Among them,RIG-I-like receptor(RLR) signaling pathway,which was established for antiviral defense,was significantly affected.Mice lacking MAVS,the adaptor of the RLR signahng pathway,were less sensitive to infection and exhibited lower IFN-P production,higher Thl-type cytokines IFN-y and IL-12 production,and lower Th2-type cytokines EL-4 and IL-13 production in the serum compared with wild-type mice.Moreover,infection of pathogenic bacteria other than Y.pestis also altered the expression of the RLR pathway,suggesting that the response of RLR pathway to bacterial infection is a universal mechanism. | Zongmin Du Huiying Yang Yafang Tan Guang Tian Qingwen Zhang Yujun Cui Yanfeng Yan Xiaohong Wu Zuyun Chen Shiyang Cao Yujing Bi Yanping Han Xiaoyi Wang Yajun Song Ruifu Yan | 2014 | Journal of Genetics and Genomics2014，41，7： | 2 |
| 13 | Monoclinic BiVO 4 micro-/nanostructures: Microwave and ultrasonic wave combined synthesis and their visible-light photocatalytic activities显示文摘 | Yafang Zhang Guangfang Li Xiaohui Yang Hao Yang Zhong Lu Rong Chen | 2013 | Journal of Alloys and Compounds2013，，： | 1 |
| 14 | Plasma Endothelial Microparticles and Their Correlation With the Presence of Hypertension and Arterial Stiffness in Patients With Type 2 Diabetes显示文摘 | Yinghua Chen Bo Feng Xu Li Yafang Ni Yun Luo | 2012 | The Journal of Clinical Hypertension2012，，7： | 1 |
| 15 | Water Holding Characteristics of Coarse Woody Debris of Abies fabri Forest on the East Slope of Tibet Sygera Mountain显示文摘Coarse woody debris( CWD) has an important role in hydrological function and water and soil conservation function of forest ecosystem especially mountain forest ecosystem. To understand water holding capacity of CWD in subalpine forest of southeast Tibet,CWD reserve of primitive A. fabri forest in Sygera Mountain was investigated by sample plot method,and water absorption and storage capacity of CWD was studied by using soaking method. The results showed that decay grade was positively related to water storage potential,that is to say,the higher the decay grade,the larger the water storage potential. Saturated water holding capacity,saturated water holding rate,effective water holding capacity and effective water holding rate of A. fabri CWD all rose with decay grade increased,and the order was Ⅴ>Ⅳ>Ⅲ>Ⅱ>Ⅰ. CWD reserve was 51.555 t/hm^2,and the maximum water storage capacity was 71.601 t/hm^2,while effective water storage capacity was 60.861 t/hm2,which was equivalent to 6.086 mm of rainfall. | Han Yanying Wei Liping Chen Chen Du Jiahao Lei Yafang Ye Yanhui | 2018 | Meteorological and Environmental Research2018，9，5： | 1 |
| 16 | Future Drought Changes in China Projected by the CMIP6 Models:Contributions from Key Factors显示文摘Model simulations show that drought may become more severe and widespread in the 21st century due to humaninduced global warming. However, the contributions from the key factors to the model-projected drought changes in China have not yet been examined in detail. We used the self-calibrated Palmer Drought Severity Index with Penman–Monteith potential evapotranspiration(scPDSIpm) based on 10 model simulations selected from the Coupled Model Intercomparison Project Phase 6(CMIP6). We investigated the contributions from precipitation(P), near-surface air temperature and specific humidity [Δ(T + q)], net surface longwave radiation(LW), net surface shortwave radiation(SW), and wind speed(WS) to the future changes in scPDSIpm, including the long-term mean, drying area,probability distribution function(PDF), drought frequency, and drought duration based on the scPDSIpm over China.Our results show that model-projected drying mainly occurs over southern China, whereas the dry areas under drought conditions increase from 20% to about 23%/30% under the two scenarios of the shared socioeconomic pathway(SSP2-4.5/SSP5-8.5) from 1985 to 2100, despite large uncertainties in individual projections partly due to internal variability. Drought frequency is projected to increases by about 10%–54%(15%–88%) under the SSP2-4.5(SSP5-8.5) scenario by the late 21st century, along with increases in drought duration. These changes are accompanied by a decrease in the mean scPDSIpm and flattening of the PDFs. The changes in drying over southern China are mainly attributed to surface warming and the increased surface vapor pressure deficit(VPD), with small contributions from changes in the surface net radiation. The changes in wetting over northern China mostly result from increased precipitation along with a small wetting effect from the changes in wind speed. | Qingxin CHEN Tianbao ZHAO Lijuan HUA Jinhua YU Yafang WANG Chuan XU | 2023 | Journal of Meteorological Research2023，37，4： | 1 |
| 17 | 靶向表观遗传相互作用为EZH2异常的实体瘤群体提供精准治疗策略显示文摘文章简介表观遗传调控异常与肿瘤发生发展密切相关,其中组蛋白甲基转移酶EZH2因在肿瘤中广泛突变和过表达,成为备受关注肿瘤治疗靶点,多个抑制剂处于临床研究。然而,目前EZH2抑制剂仅对少量血液系统肿瘤有效,对实体瘤治疗基本无效,极大限制了其临床应用空间。 | Xun Huang Juan Yan Min Zhang Yafang Wang Yi Chen Xuhong Fu Rongrui Wei Xing-ling Zheng Zhiwei Liu Xiong Zhang Hong Yang Bingbing Hao Yan-yan Shen Yi Su Xiaoji Cong Min Huang 谭敏佳 丁健 耿美玉 | 2019 | 科学新闻2019，0，2： | 1 |
| 18 | Distinct lung microbial community states in patients with pulmonary tuberculosis显示文摘An improved understanding of the lung microbiome may lead to better strategies to diagnose, treat, and prevent pulmonary tuberculosis (PTB). However, the characteristics of the lung microbiomes of patients with TB remain largely undefined. In this study, 163 bronchoalveolar lavage (BAL) samples were collected from 163 sputum-negative suspected PTB patients. Furthermore, 12 paired BAL samples were obtained from 12 Mycobacterium tuberculosis-positive (MTB+) patients before and after negative conversion following a two-month anti-TB treatment. The V3–V4 region of the 16S ribosomal RNA (rRNA) gene was used to characterize the microbial composition of the lungs. The results showed that the prevalence of MTB in the BAL samples was 42.9% (70/163) among the sputum-negative patients. The α-diversity of lung microbiota was significantly less diverse in MTB+ patients compared with Mycobacterium tuberculosis-negative (MTB–) patients. There was a significant difference in β-diversity between MTB+ and MTB– patients. MTB+ patients were enriched with Anoxybacillus, while MTB– patients were enriched with Prevotella, Alloprevotella, Veillonella, and Gemella. There was no significant difference between the Anoxybacillus detection rates of MTB+ and MTB– patients. The paired comparison between the BAL samples from MTB+ patients and their negative conversion showed that BAL negative-conversion microbiota had a higher α-diversity. In conclusion, distinct features of airway microbiota could be identified between samples from patients with and without MTB. Our results imply links between lung microbiota and different clinical groups of active PTB. | Yongfeng Hu Ying Kang Xi Liu Min Cheng Jie Dong Lilian Sun Yafang Zhu Xianwen Ren Qianting Yang Xinchun Chen Qi Jin Fan Yang | 2020 | Science China(Life Sciences)2020，63，10： | 1 |
| 19 | Simulation of hot deformation of TiAl based alloy containing high Nb 显示文摘 | Li Shusuo Su Xikong Han Yafang Xu Xiangjun Chen Guoliang | 2005 | Intermetallics2005，13，： | 1 |
| 20 | Immune‑Ageing Evaluation of Peripheral T and NK Lymphocyte Subsets in Chinese Healthy Adults显示文摘Ageing is often accompanied with a decline in immune system function,resulting in immune ageing.Numerous studies have focussed on the changes in different lymphocyte subsets in diseases and immunosenescence.The change in immune phenotype is a key indication of the diseased or healthy status.However,the changes in lymphocyte number and phenotype brought about by ageing have not been comprehensively analysed.Here,we analysed T and natural killer(NK)cell subsets,the phenotype and cell differentiation states in 43,096 healthy individuals,aged 20–88 years,without known diseases.Thirty-six immune parameters were analysed and the reference ranges of these subsets were established in different age groups divided into 5-year intervals.The data were subjected to random forest machine learning for immune-ageing modelling and confirmed using the neural network analysis.Our initial analysis and machine modelling prediction showed that na.ve T cells decreased with ageing,whereas central memory T cells(Tcm)and effector memory T cells(Tem)increased cluster of differentiation(CD)28-associated T cells.This is the largest study to investigate the correlation between age and immune cell function in a Chinese population,and provides insightful differences,suggesting that healthy adults might be considerably influenced by age and sex.The age of a person's immune system might be different from their chronological age.Our immune-ageing modelling study is one of the largest studies to provide insights into‘immune-age’rather than‘biological-age’.Through machine learning,we identified immune factors influencing the most through ageing and built a model for immune-ageing prediction.Our research not only reveals the impact of age on immune parameter differences within the Chinese population,but also provides new insights for monitoring and preventing some diseases in clinical practice. | Zhenghu Jia Zhiyao Ren Dongmei Ye Jiawei Li Yan Xu Hui Liu Ziyu Meng Chengmao Yang Xiaqi Chen Xinru Mao Xueli Luo Zhe Yang Lina Ma Anyi Deng Yafang Li Bingyu Han Junping Wei Chongcheng Huang Zheng Xiang Guobing Chen Peiling Li Juan Ouyang Peisong Chen Oscar Junhong Luo Yifang Gao Zhinan Yin | 2023 | Phenomics2023，3，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员