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| 1 | Uplift and evolution of Helan Mountain显示文摘The Helan Mountain lies in the northwest margin of Ordos Basin and its uplift periods have close relations with the tectonic feature and evolution of the basin. There are many views on the uplift time of Helan Mountain, which is Late Triassic and Late Jurassic. It is concluded by the present strata, magmatic rock and hot fluid distribution that the Helan Mountain does not uplift in Late Triassic to Middle Jurassic but after Middle Jurassic. Through the research of the sedimentary strata and deposit rate in Yinchuan Graben which is near to the Helan Mountain, it is proved that the Helan Mountain uplifts in Eocene with a huge scale and in Pliocene with a rapid speed. The fission track analysis of apatite and zircon can be used to determine the precise uplift time of Helan Mountain, which shows that four stages of uplifting or cooling: Late Jurassic to the early stage of Early Cretaceous, mid-late stage of Early Cretaceous, Late Cretaceous and since Eocene. During the later two stages the uplift is most apparent and the mid-late stage of Early Cretaceous is a regional cooling course. Together with several analysis ways, it is considered that the earliest time of Helan Mountain uplift is Late Jurassic with a limited scale and that Late Cretaceous uplift is corresponding to the whole uplift of Ordos Basin, extensive uplift happened in Eocene and rapid uplift in Pliocene. | ZHAO HongGe LIU ChiYang WANG Feng WANG JianQiang LI Qiong YAO YaMing | 2007 | Science China Earth Sciences2007，50，z2： | 7 |
| 2 | The relationship between thermo-mechanical history,microstructure and mechanical properties in additively manufactured CoCrFeMnNi high entropy alloy显示文摘Here,a single-track CoCrFeMnNi high entropy alloy(HEA)was successfully fabricated by laser melting deposition(LMD).Combining the experimental observations and numerical simulation,the microstructure and mechanical properties of the as-deposited parts were systematically studied from the perspective of thermo-mechanical history experienced during the LMD process.The strengthening mechanisms of the LMDed CoCrFeMnNi HEA parts were clarified.The frictional stress strengthening,grain boundary strengthening and dislocation strengthening contributed the whole yield strength of the parts.Dislocation strengthening dominated the strengthening mechanism.It was expected that the establishment of the relationship between thermo-mechanical history,microstructure and mechanical properties of the LMDed CoCrFeMnNi HEA could shed more insights into achieving HEA parts with the desired microstructure and high performance. | Hongge Li Yongjiang Huang Jianfei Sun Yunzhuo Lu | 2021 | Journal of Materials Science & Technology2021，，18： | 3 |
| 3 | Sensitivity analysis of Biome-BGCMuSo for gross and net primary productivity of typical forests in China显示文摘Background:Process-based models are widely used to simulate forest productivity,but complex parameterization and calibration challenge the application and development of these models.Sensitivity analysis of numerous parameters is an essential step in model calibration and carbon flux simulation.However,parameters are not dependent on each other,and the results of sensitivity analysis usually vary due to different forest types and regions.Hence,global and representative sensitivity analysis would provide reliable information for simple calibration.Methods:To determine the contributions of input parameters to gross primary productivity(GPP)and net primary productivity(NPP),regression analysis and extended Fourier amplitude sensitivity testing(EFAST)were conducted for Biome-BGCMuSo to calculate the sensitivity index of the parameters at four observation sites under climate gradient from ChinaFLUX.Results:Generally,GPP and NPP were highly sensitive to C:Nleaf(C:N of leaves),Wint(canopy water interception coefficient),k(canopy light extinction coefficient),FLNR(fraction of leaf N in Rubisco),MRpern(coefficient of linear relationship between tissue N and maintenance respiration),VPDf(vapor pressure deficit complete conductance reduction),and SLA1(canopy average specific leaf area in phenological phase 1)at all observation sites.Various sensitive parameters occurred at four observation sites within different climate zones.GPP and NPP were particularly sensitive to FLNR,SLA1 and Wint,and C:Nleaf in temperate,alpine and subtropical zones,respectively.Conclusions:The results indicated that sensitivity parameters of China's forest ecosystems change with climate gradient.We found that parameter calibration should be performed according to plant functional type(PFT),and more attention needs to be paid to the differences in climate and environment.These findings contribute to determining the target parameters in field experiments and model calibration. | Hongge Ren Li Zhang Min Yan Xin Tian Xingbo Zheng | 2022 | Forest Ecosystems2022，9，1： | 2 |
| 4 | Impact of crizotinib on long-term survival of ALK-positive advanced non-small-cell lung cancer: A Chinese multicenter cohort study显示文摘Objective: Crizotinib has demonstrated promising efficacy in patients with anaplastic lymphoma kinase(ALK)-positive non-small-cell lung cancer(NSCLC) in clinical trials. We conducted this retrospective multicenter study to assess the outcomes of crizotinib therapy in, to our knowledge, a large sample cohort of patients with ALKpositive advanced NSCLC.Methods: We reviewed the medical records of 484 unselected ALK-positive NSCLC patients treated with crizotinib at 5 cancer centers in China from January 2013 to November 2017. Clinical data were collected from the initiation of crizotinib therapy to Response Evaluation Criteria in Solid Tumors(RECIST)-defined progressive disease(PD).Results: A total of 428 eligible ALK-positive NSCLC patients were enrolled, 273(63.8%) of whom received crizotinib as first-line treatment. The median progression-free survival(PFS) and overall survival(OS) from the initiation of crizotinib treatment were 14.4 [95% confidence interval(95% CI), 12.4-16.4] months and 53.4(95%CI, 33.7-73.1) months, respectively. In subgroup analyses, patients who received crizotinib as first-line treatment showed a higher disease control rate(DCR) and a longer median OS compared with second-/later-line crizotinib treatment(94.8% and OS not reached vs. 89.0% and 40.5 months, respectively). For 261 patients with RECISTdefined PD, multivariate Cox analysis revealed that in patients who received first-line crizotinib therapy, continued crizotinib beyond progressive disease(CBPD) and next-generation ALK inhibitors after crizotinib failure were associated with improved survival.Conclusions: This study has demonstrated the clinically meaningful benefit of crizotinib treatment in a large cohort of Chinese ALK-positive NSCLC patients. CBPD and next-generation ALK inhibitor treatment may provide improved survival after RECIST-defined progression on crizotinib. | Puyuan Xing Di Ma Qiang Wang Xuezhi Hao Mengzhao Wang Yan Wang Li Shan Tao Xin Li Liang Hongge Liang Yang Du Zhaohui Zhang Junling Li | 2019 | Chinese Journal of Cancer Research2019，31，3： | 2 |
| 5 | QTL mapping of agronomic and economic traits for four F_(2)populations of upland cotton显示文摘Background:Upland cotton(Gossypium hirsutum)accounts for more than 90%of the annual world cotton output because of its high yield potential.However,yield and fiber quality traits often show negative correlations.We constructed four F_(2)populations of upland cotton,using two normal lines(4133B and SGK9708)with high yield potential but moderate fiber quality and two introgression lines(Suyuan04–3 and J02–247)with superior fiber quality,and used them to investigate the genetic basis underlying complex traits such as yield and fiber quality in upland cotton.We also phenotyped eight agronomic and economic traits and mapped quantitative trait loci(QTLs).Results:Extensive phenotype variations and transgressive segregation were found across the segregation populations.We constructed four genetic maps of 585.97 centiMorgan(cM),752.45 cM,752.45 cM,and 1163.66 cM,one for each of the four F_(2)populations.Fifty QTLs were identified across the four populations(7 for plant height,27 for fiber quality and 16 for yield).The same QTLs were identified in different populations,including qBW4 and qBW2,which were linked to a common simple sequence repeat(SSR)marker,NAU1255.A QTL cluster containing eight QTLs for six different traits was characterized on linkage group 9 of the 4133B×Suyuan04–3 population.Conclusions:These findings will provide insights into the genetic basis of simultaneous improvement of yield and fiber quality in upland cotton breeding. | LI Hongge PAN Zhaoe HE Shoupu JIA Yinhua GENG Xiaoli CHEN Baojun WANG Liru PANG Baoyin DU Xiongming | 2021 | Journal of Cotton Research2021，4，1： | 2 |
| 6 | An oral second-generation proteasome inhibitor oprozomib significantly inhibits lung cancer in a p53 independent manner in vitro显示文摘The destruction of proteins via the ubiquitin-proteasome system is amulti-step,complex process involving polyubiquitination of substrate proteins,follow ed by proteolytic degradation by the m acrom olecular 26S proteasome complex.Inhibitors of the proteasome prom ote the accum ulation of proteins that are deleterious to cell survival and are prom ising anticancer agents.Oprozomib(OPZ),an oral second-generation proteasome inhibitor,has been shown to inhibit the grow th of several cancers in preclinical and clinical trials,including m ultiple m yelom a and head and neck cancers,but its effects on lung cancer has not yet been determ ined.In this study,we evaluated the inhibitory effects of OPZ on lung cancer cell lines in vitro.The results showed that OPZ significantly suppressed cell proliferation and strongly induced apoptosis in both tested lung cancer cells independent of p53 expression.OPZ was able to cause obvious caspase 3 and PARP cleavages and stabilize p53 and its transcriptional targets p21,PUMA,and Noxa.Moreover,OPZ was capable of sensitizing lung cancer cells to the conventional chem otherapeutic drug cisplatin.Our study provides preclinical data and sheds light on the potential applications of proteasome inhibitor OPZ in lung cancer treatment. | Hongge Zhu Tianhai Wang Zhou Xin Yiyi Zhan Guoming Gu Xiaoqin Li Xiuli Wang Shune Yang Chunling Liu | 2019 | Acta Biochimica et Biophysica Sinica2019，51，10： | 2 |
| 7 | Effects of Cr on the structural and electrochemical properties of TiV-based two-phase hydrogen storage alloys 显示文摘 | Hongge Pan Rui Li Mingxia Gao | 2005 | Journal of Alloys and Compounds2005，，： | 1 |
| 8 | Rare earth–Mg–Ni-based hydrogen storage alloys as negative electrode materials for Ni/MH batteries显示文摘 | Yongfeng Liu Yanhui Cao Li Huang Mingxia Gao Hongge Pan | 2010 | Journal of Alloys and Compounds2010，，3： | 1 |
| 9 | Identification and expression analysis of Tubulin gene family in upland cotton显示文摘Background:Cott on fibers are single-celled exte nsions of the seed epidermis,a model tissue for studying cytoskeleton.Tubulin genes play a critical role in synthesizing the microtubules(MT)as a core element of the cytoskeleton.However,there is a lack of studies concerning the systematic characterization of the tubulin gene family in cotton.Therefore,the identification and portrayal of G.hirsutum tubulin genes can provide key targets for molecular manipulation in cotton breeding.Result:In this study,we investigated all tubulin genes from different plant species and identified 98 tubulin genes in G.hirsutum.Phylogenetic an a lysis showed that tubulin family genes were classified into three subfamilies.The protein motifs and gene structure ofβ-tubulin genes are more conserved compared withγ-tubulin genes.Most tubulin genes are located at the proximate ends of the chromosomes.Spatiotemporal expression pattern by transcriptome and qRT-PCR analysis revealed that 12α-tubulin andβ-tubulin genes are specifically expressed during different fiber development stages.However,Gh.A03G027200,Gh.D03G 169300,and Gh.A1lG258900 had differential expression patterns at distinct stages of fiber development in varieties JO2508 and ZRI015.Conclusion:In this study,the evol ut io nary an alysis showed that the tubulin genes were divided into three clades.The genetic structures and molecular functions were highly con served in different plants.Three candidate genes,Gh.A03G027200f Gh.D03G169300,and Gh.A11G258900 may play a key role during fiber development complementing fiber length and strength. | CHEN Baojun ZHAO Junjie FU Guoyong PEI Xinxin PAN Zhao'e LI Hongge AHMED Haris HE Shoupu DU Xiongming | 2021 | Journal of Cotton Research2021，4，3： | 1 |
| 10 | Micropower fully integrated CMOS readout interface for neural recording application显示文摘 | Hongge Li Zhao Wei Zhang Youguang | 2010 | 2010，，02： | 1 |
| 11 | Preparation and catalytic effect of porous Co_3O_4 on the hydrogen storage properties of a Li-B-N-H system显示文摘A porous Co_3O_4 with a particle size of 1–3 μm was successfully prepared by heating Co-based metal organic frameworks MOF-74(Co) up to 500 °C in air atmospheric conditions. The as-prepared porous Co_3O_4 significantly reduced the dehydrogenation temperatures of the LiBH_4-2LiNH_2 system and improved the purity of the released hydrogen. The LiBH_4-2LiNH_2-0.05/3Co_3O_4 sample started to release hydrogen at 140 °C and released hydrogen levels of approximately 9.7 wt% at 225 °C. The end temperature for hydrogen release was lowered by 125 °C relative to that of the pristine sample. Structural analyses revealed that the as-prepared porous Co_3O_4 is in-situ reduced to metallic Co, which functions as an active catalyst, reducing the kinetic barriers and lowering the dehydrogenation temperatures of the LiBH_4-2LiNH_2 system. More importantly, the porous Co_3O_4-containing sample exhibited partially improved reversibility for hydrogen storage in the LiBH_4-2LiNH_2 system. | You Li Yi Zhang Mingxia Gao Hongge Pan Yongfeng Liu | 2017 | Progress in Natural Science:Materials International2017，27，1： | 1 |
| 12 | Sub-threshold-based Mira-low-power neural spike detector显示文摘 | Hongge Li Qicheng Xu | 2011 | Electronics Letters2011，47，6： | 1 |
| 13 | A complete assembly of the rice Nipponbare reference genome显示文摘Dear Editor,In 2005,the current commonly used rice reference genome(Oryza sativa ssp.japonica cv.Nipponbare)was initially released by the International Rice Genome Sequencing Project(International Rice Genome Sequencing Project,2005).Thereafter,the reference genome was further updated in 2013 with improved genome assembly(IRGSP-1.0)and gene annotations(MSU7,RAP-DB)(Kawahara et al.,2013;Sakai et al.,2013).In the past 10 years,this reference has been serving as one of the most important genetic resources for subsequent rice functional genomics efforts.As several rice genomes had been assembled into gapless chromosomes with only 2–5 telomeres absent(Li et al.,2021;Song et al.,2021;Zhang et al.,2022),the IRGSP1.0 and its annotations still performed as the most widely used reference.However,limitations of sequencing technology and intricate genomic organization led to an under-representation of complex regions in this reference,leaving a total of 72 major gaps(including 19 telomeres),167 minor gaps,and 779 unknown bases(Kawahara et al.,2013),with an estimated length of3%of the genome unsolved. | Lianguang Shang Wenchuang He Tianyi Wang Yingxue Yang Qiang Xu Xianjia Zhao Longbo Yang Hong Zhang Xiaoxia Li Yang Lv Wu Chen Shuo Cao Xianmeng Wang Bin Zhang Xiangpei Liu Xiaoman Yu Huiying He Hua Wei Yue Leng Chuanlin Shi Mingliang Guo Zhipeng Zhang Bintao Zhang Qiaoling Yuan Hongge Qian Xinglan Cao Yan Cui Qianqian Zhang Xiaofan Dai Congcong Liu Longbiao Guo Yongfeng Zhou Xiaoming Zheng Jue Ruan Zhukuan Cheng Weihua Pan Qian Qian | 2023 | Molecular Plant2023，16，8： | 1 |
| 14 | Powder preparation with evaporation and condensation method显示文摘 | Li Yunong Chen Qing | 2005 | Journal of Hunan University Natural Sciences2005，32，2： | 1 |
| 15 | Effects of Different Plant Hormones for Microbial Degradation of PASHs and Diesel under Aerobic Conditions显示文摘The effects of plant hormones for biodegradation of polycyclic aromatic sulfur heterocycles(PASHs)and diesel fuel were studied.Indole butyric acid(IBA)and gibberellin were found to promote biodegradation of DBT and diesel,respectively.Concentrations of plant hormones,pH,temperature,soil moisture and substrate concentrations were optimized in microbial metabolic processes.Two main factors including temperature and IBA concentration were determined by factor analysis in DBT biodegradation.And soil moisture and diesel concentration were important factors in diesel biodegradation.Binding sites between cell surface and DBT or diesel components were performed by molecular operating environment(MOE).This study suggested that plant hormones could be applied to effectively remove pollutants in environment. | Shang Xiufang Li Lin Xiao Xinfeng Xue Jianliang Gao Yu Gao Hongge Hu Shugang | 2021 | China Petroleum Processing & Petrochemical Technology2021，23，1： | 1 |
| 16 | Influences of Co substitution and annealing treatment on the structure and electrochemical properties of hydrogen storage alloys La 0.7 Mg 0.3 Ni 2.45 - x Co 0.75 + x Mn 0.1 Al 0.2 ( x = 0.00 , 0.15 , 0.30 )显示文摘 | He Miao Hongge Pan Shengcai Zhang Ni Chen Rui Li Mingxia Gao | 2007 | International Journal of Hydrogen Energy2007，，15： | 1 |
| 17 | Improved Hydrogen‐Storage Thermodynamics and Kinetics for an RbF‐Doped Mg(NH<sub>2</sub>)<sub>2</sub>–2 LiH System显示文摘 | Chao Li Yongfeng Liu Yingjie Gu Mingxia Gao Hongge Pan | 2013 | Chem Asian J2013，，9： | 1 |
| 18 | Effects of Ni on the structural and electrochemical properties of Ti-V-based hydrogen storage alloys 显示文摘 | PAN Hongge LI Rui GAO Mingxia | 2006 | International Journal of Hydrogen Energy2006，31，9： | 1 |
| 19 | Effects of Cr on the structural and electrochemical properties of TiV-based two-phase hydrogen storage alloys 显示文摘 | Pan Hongge Li Rui Gao Mingxia | 2005 | J Alloys and Compounds2005，404，406： | 1 |
| 20 | Effect of Ni on the structural and electrochemical properties of Ti-V-based hydrogen storage alloys 显示文摘 | Pan Hongge Li Rui Gao Mingxia | 2006 | Int J Hydrogen Energy2006，31，： | 1 |
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