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| 1 | Spatial and temporal change patterns of net primary productivity and its response to climate change in the Qinghai–Tibet Plateau of China from 2000 to 2015显示文摘The vegetation ecosystem of the Qinghai–Tibet Plateau in China,considered to be the′′natural laboratory′′of climate change in the world,has undergone profound changes under the stress of global change.Herein,we analyzed and discussed the spatial-temporal change patterns and the driving mechanisms of net primary productivity(NPP)in the Qinghai–Tibet Plateau from 2000 to 2015 based on the gravity center and correlation coefficient models.Subsequently,we quantitatively distinguished the relative effects of climate change(such as precipitation,temperature and evapotranspiration)and human activities(such as grazing and ecological construction)on the NPP changes using scenario analysis and Miami model based on the MOD17A3 and meteorological data.The average annual NPP in the Qinghai–Tibet Plateau showed a decreasing trend from the southeast to the northwest during 2000–2015.With respect to the inter-annual changes,the average annual NPP exhibited a fluctuating upward trend from 2000 to 2015,with a steep increase observed in 2005 and a high fluctuation observed from 2005 to 2015.In the Qinghai–Tibet Plateau,the regions with the increase in NPP(change rate higher than 10%)were mainly concentrated in the Three-River Source Region,the northern Hengduan Mountains,the middle and lower reaches of the Yarlung Zangbo River,and the eastern parts of the North Tibet Plateau,whereas the regions with the decrease in NPP(change rate lower than–10%)were mainly concentrated in the upper reaches of the Yarlung Zangbo River and the Ali Plateau.The gravity center of NPP in the Qinghai–Tibet Plateau has moved southwestward during 2000–2015,indicating that the increment and growth rate of NPP in the southwestern part is greater than those of NPP in the northeastern part.Further,a significant correlation was observed between NPP and climate factors in the Qinghai–Tibet Plateau.The regions exhibiting a significant correlation between NPP and precipitation were mainly located in the central and eastern Qinghai–Tibet Plateau,and the regions exhibiting a significant correlation between NPP and temperature were mainly located in the southern and eastern Qinghai–Tibet Plateau.Furthermore,the relative effects of climate change and human activities on the NPP changes in the Qinghai–Tibet Plateau exhibited significant spatial differences in three types of zones,i.e.,the climate change-dominant zone,the human activity-dominant zone,and the climate change and human activity interaction zone.These research results can provide theoretical and methodological supports to reveal the driving mechanisms of the regional ecosystems to the global change in the Qinghai–Tibet Plateau. | GUO Bing ZANG Wenqian YANG Fei HAN Baomin CHEN Shuting LIU Yue YANG Xiao HE Tianli CHEN Xi LIU Chunting GONG Rui | 2020 | Journal of Arid Land2020，12，1： | 12 |
| 2 | SARS-CoV-2 promotes RIPK1 activation to facilitate viral propagation显示文摘Coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),is the ongoing global pandemic that poses substantial challenges to public health worldwide.A subset of COVID-19 patients experience systemic inflammatory response,known as cytokine storm,which may lead to death.Receptor-interacting serine/threonine-protein kinase 1(RIPK1)is an important mediator of inflammation and cell death.Here,we examined the interaction of RIPK1-mediated innate immunity with SARS-CoV-2 infection.We found evidence of RIPK1 activation in human COVID-19 lung pathological samples,and cultured human lung organoids and ACE2 transgenic mice infected by SARS-CoV-2.Inhibition of RIPK1 using multiple smallmolecule inhibitors reduced the viral load of SARS-CoV-2 in human lung organoids.Furthermore,therapeutic dosing of the RIPK1 inhibitor Nec-1s reduced mortality and lung viral load,and blocked the CNS manifestation of SARS-CoV-2 in ACE2 transgenic mice.Mechanistically,we found that the RNA-dependent RNA polymerase of SARS-CoV-2,NSP12,a highly conserved central component of coronaviral replication and transcription machinery,promoted the activation of RIPK1.Furthermore,NSP12323L variant,encoded by the SARS-CoV-2 C14408T variant first detected in Lombardy,Italy,that carries a Pro323Leu amino acid substitution in NSP12,showed increased ability to activate RIPK1.Inhibition of RIPK1 downregulated the transcriptional induction of proinflammatory cytokines and host factors including ACE2 and EGFR that promote viral entry into cells.Our results suggest that SARS-CoV-2 may have an unexpected and unusual ability to hijack the RIPK1-mediated host defense response to promote its own propagation and that inhibition of RIPK1 may provide a therapeutic option for the treatment of COVID-19. | Gang Xu Ying Li Shengyuan Zhang Haoran Peng Yunyun Wang Dekang Li Taijie Jin Zhuohao He Yilun Tong Chunting Qi Guowei Wu Kangyun Dong Jizhou Gou Yang Liu Tongyang Xiao Jing Qu Liang Li Liang Liu Ping Zhao Zheng Zhang Junying Yuan | 2021 | Cell Research2021，31，12： | 6 |
| 3 | Impact of nonlinear transfer function and imperfect splitting ratio of MZM on optical up-conversion employing double sideband with carrier suppression modulation显示文摘 | Liu Chunting Chen Jason(Jyehong) Dai Sheng-Peng | 2008 | Lightw Technol2008，26，15： | 1 |
| 4 | Cognition in Chinese children with benign childhood epilepsy with centrotemporal spikes (BCECTS)显示文摘 | Xinjie Liu Xiaoli Zhang Qizheng Han Jing Guo Chunting Wang | 2011 | Neuroscience Letters2011，，1： | 1 |
| 5 | Philadelphia chromosome-positive acute myeloid leukemia with masses and osteolytic lesions: finding of 18F-FDG PET/CT显示文摘 | Zhan Su Fengyu Wu Weiyu Hu Xiaodan Liu Shaoling Wu Xianqi Feng Zhongguang Cui Jie Yang Zhenguang Wang Hongzai Guan Hongguo Zhao Wei Wang Chunting Zhao Jun Peng | 2017 | Frontiers of Medicine2017，11，3： | 1 |
| 6 | Analytical Method for Predicting the Air - Gap Flux of Interior - Type Permanent -Magnnet Machines显示文摘 | Mi Chunting Mariano Filippa Liu Weiguo | 2004 | IEEE Transactions on Magneties2004，40，1： | 1 |
| 7 | Formation mechanism and magnetic properties of three different hematite nanostructures synthesized by one-step hydrothermal procedure显示文摘The spindle-like, tubular, and tire-like hematite were successively fabricated by a facile, one-step hydrothermal procedure, which is of great importance in facilitating the controllable-synthesis process of commercial industrialization. A mechanism involving a formation-dissolution process was proposed based on the X-ray diffraction, scanning electron microscopy, trans-mission electron microscopy, and high-resolution transmission electron microscopy analysis. It was demonstrated that the presence of phosphate ions during the reaction process is crucial to the morphology evolution of hematite. Their different ad-sorption ability on the different crystallographic planes of hematite and a coordination effect with ferric ions could promote the preferential dissolution of the spindle-like hematite precursors along the long axis [001] from the tips down to the interior, and thus yield the tubular and tire-like hematite one by one with the increasing reaction time. The magnetic measurements have also been performed to investigate the different magnetic properties such as coercivity and low-temperature transition behavior of three different hematite nanostructures. | LIU ChunTing MA Ji LIU YuLiang | 2011 | Science China Chemistry2011，54，10： | 1 |
| 8 | Analytical method for predicting the air-gap flux of interior-type permanent magnet machine显示文摘 | Mi Chunting Mariano Filippa Liu Weiguo | 2004 | IEEE Transactions on Magnetics2004，40，1： | 1 |
| 9 | Analytical method for predicting the air-gap flux of interior-type permanent magnet machine 显示文摘 | Mi Chunting Mariano F Liu Weiguo | 2004 | IEEE Transactions on Magnetics2004，40，1： | 1 |
| 10 | Analytical method for predicting the air-gap flux of interior-type permanent-magnet machine显示文摘 | Chunting M Filippa M Liu Weiguo | 2004 | IEEE Transactions on Magnetics2004，40，1： | 1 |
| 11 | Biodiversity conservation in China:A review of recent studies and practices显示文摘Biodiversity conservation plays an important role in the sustainable development of human society.China had made significant progress in biodiversity conservation studies and practices.This paper reviews major achievements in China in the past decades,especially those since 2010.In terms of the science behind biodiversity conservation,Chinese scholars have made significant contributions to priority research subjects,including mechanisms for maintaining biological communities and the relationship between biodiversity and ecosystem functioning.Simultaneously,biodiversity conservation and management systems specific to China have been basically established.The Chinese Government and researchers have undertaken a number of investigations,scientific studies,and monitoring,and have established relevant databases.With efforts taken to protect and restore biodiversity and ecosystems,the concept of biodiversity has gradually become popular in China.This review is an attempt to share with the world the learning from China’s progress towards becoming an ecological civilization and highlights that the efforts towards biodiversity conservation need to be organically integrated with sustainable development goals. | Wei Wang Chunting Feng Fangzheng Liu Junsheng Li | 2020 | Environmental Science and Ecotechnology2020，，2： | 0 |
| 12 | Structure-based development of potent and selective type-II kinase inhibitors of RIPK1显示文摘Receptor-interacting serine/threonine-protein kinase 1(RIPK1)functions as a key regulator in inflammation and cell death and is involved in mediating a variety of inflammatory or degenerative diseases.A number of allosteric RIPK1 inhibitors(RIPK1i)have been developed,and some of them have already advanced into clinical evaluation.Recently,selective RIPK1i that interact with both the allosteric pocket and the ATP-binding site of RIPK1 have started to emerge.Here,we report the rational development of a new series of type-II RIPK1i based on the rediscovery of a reported but mechanistically atypical RIPK3i.We also describe the structure-guided lead optimization of a potent,selective,and orally bioavailable RIPK1i,62,which exhibits extraordinary efficacies in mouse models of acute or chronic inflammatory diseases.Collectively,62 provides a useful tool for evaluating RIPK1 in animal disease models and a promising lead for further drug development. | Ying Qin Dekang Li Chunting Qi Huaijiang Xiang Huyan Meng Jingli Liu Shaoqing Zhou Xinyu Gong Ying Li Guifang Xu Rui Zu Hang Xie Yechun Xu Gang Xu Zheng Zhang Shi Chen Lifeng Pan Ying Li Li Tan | 2024 | Acta Pharmaceutica Sinica B2024，14，1： | 0 |
| 13 | Notoginsenoside R1 Protects against Diabetic Nephropathy through TXNIP-NLRP3 Signaling Pathway显示文摘Background:Diabetic nephropathy(DN)is a microvascular complication of diabetes mellitus(DM).DN results from many factors,including changes in glomerular hemodynamics,oxidative stress and inflammation,and in-terstitial fibrosis and tubular atrophy.Panax notoginseng,a commonly used Chinese medicine,has been used in the treatment of kidney disease.Notoginsenoside R1(NGR1),the main compound isolated from P.notoginseng,has been reported to have a renoprotective role in DN.However,the therapeutic effect and mechanism of NGR1 in DN remain unclear.Objective:The present study aimed to investigate the therapeutic effect and mechanism of NGR1 in DN.Methods:In this study,mouse podocytes(MPC-5 cells)and db/db mice were used to investigate the effect of NGR1 on DN in vitro and in vivo,respectively.Blood glucose,renal function,inflammatory factors,and PI3K/AKT-Nrf2-NLRP3 signaling pathway proteins were assessed.Results:The study results indicated that NGR1 reversed cell viability induced by high glucose(HG,30 mM).The related mechanism results showed that NGR1 decreased oxidative stress by inhibiting reactive oxygen species(ROS)level and upregulating the expression of Nrf2,NQO1,and HO-1 via TXNIP targeting.In addition,NLRP3 inflammasome and PI3K/AKT were engaged in NGR1-based protection against HG-stimulated podocytes.In db/db mice,NGR1 significantly decreased blood glucose,urine protein,urine output,blood urea nitrogen,and other parameters as well as reversed kidney injury by inhibiting oxidative stress and proinflammatory response.Conclusion:Taken together,this study revealed that NGR1 exerted a significant therapeutic effect on DN both in vitro and in vivo via a mechanism related to the TXNIP-Nrf2 pathway and NLRP3 inflammasome,suggesting that NGR1 is a potential therapeutic option for DN. | Chunting Zhang Renyikun Yuan Siyuan Li Guodong Huang Kaili Sun Jiaping Pan Qiuxia Liu Xiang Gao Zhijing Wang Tongyu Li Shilong Lu Jianzhen Lv Liting Huang Hongwei Gao | 2023 | Clinical Complementary Medicine and Pharmacology2023，3，4： | 0 |
| 14 | Morphology and internal architecture of a banner bank off Chengshan Headland, Shandong Peninsula显示文摘A banner bank off the north coast of the Chengshan Headland, Shandong Peninsula, has been described on the basis of echo sounder bathymetry, side-scan sonar and high-resolution seismic data sets. The bank is in NWW direction, approximately parallel to the coastline. The bank consists of sandy silt or clayed silt. Sand waves and megaripples are observed on the north side, which result from strong tidal currents around the headland and storm waves in winter. These bed forms indicate that the bank is influenced by the modern hydrodynamics. The bank is separated from the coast and Holocene subaqueous clinoform around the Shandong Peninsula in its east part. High-resolution seismic profiles reveal that the bank was formed during two periods: the earlier seismic unit Ua, and later seismic units Ub and Uc which overlays Ua with erosional surfaces on its south side and north side, respectively. As comparing with the clinoform, the bank has a different internal architecture. In the west of the bank, however, topography and surface sediment characteristics suggest that the bank links to the clinoform. The authors propose that seismic Ua is a residual part of early clinoform deposit. After the sediments in the north and south of Ua were eroded by strong currents, the Ub and Uc started to deposit probably by a complex hydrodynamic process. These results provide new insights into the evolution of the bank and its relation with the Holocene subqueous clinoform. | ZHOU Liangyong LIU Jia XUE Chunting KONG Xianghuai BAI Dapeng | 2009 | Acta Oceanologica Sinica2009，28，5： | 0 |
| 15 | An antigen self-assembled and dendritic cell-targeted nanovaccine for enhanced immunity against cancer显示文摘The rise of nanotechnology has opened new horizons for cancer immunotherapy.However,most nano vaccines fabricated with nanomaterials suffer from carrier-related concerns,including low drug loading capacity,unpredictable metabolism,and potential systemic toxicity,which bring obstacles for their clinical translation.Herein,we developed an antigen self-assembled nanovaccine,which was resulted from a simple acryloyl modification of the antigen to induce self-assembly.Furthermore,a dendritic cell targeting head mannose monomer and a mevalonate pathway inhibitor zoledronic acid(Zol)were integrated or absorbed onto the nanoparticles(denoted as MEAO-Z)to intensify the immune response.The synthesized nano vaccine with a diameter of around 70 nm showed successful lymph node transportation,high dendritic cell internalization,promoted costimulatory molecule expression,and preferable antigen cross-presentation.In virtue of the above superiorities,MEAO-Z induced remarkably higher titers of serum antibody,stronger cytotoxic T lymphocyte immune responses and IFN-γsecretion than free antigen and adjuvants.In vivo,MEAO-Z significantly suppressed EG7-OVA tumor groth and prolonged the survival time of tumor-bearing mice.These results indicated the translation promise of our self-assembled nano vaccine for immune potentiation and cancer immunotherapy. | Yunting Zhang Min Jiangy Guangsheng Du Xiaofang Zhong Chunting He Ming Qin Yingying Hou Rong Liu Xun Sun | 2023 | Acta Pharmaceutica Sinica B2023，13，8： | 0 |
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