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| 1 | Reactive capillary hemangiomas: a novel dermatologic toxicity following anti-PD-1 treatment with SHR-1210显示文摘Objective: SHR-1210 is a new and promising anti-PD-1 agent for solid tumors. During the phase I study of SHR-1210, we encountered a novel but prevalent immune-related dermatologic toxicity: reactive capillary hemangiomas(RCHs). Thus we tried to summarize the features of RCHs and estimate their relationship with tumor response.Methods: This prospective observational study systematically enrolled 98 patients with advanced solid tumors from April 27th,2016 to June 8th, 2017 in the context of the phase I clinical study of SHR-1210. This report focused on the skin toxicities. Patients underwent entire skin inspection every two weeks while taking medication. The clinical course of RCHs was recorded and their association with tumor response was estimated. The data cut-off date was November 15th, 2017.Results: After a median follow-up of 242(range, 29–567) days, RCHs were observed in 85.7%(84/98) of patients on cutaneous/mucosal surfaces; 84.5%(71/84) of the RCHs were evaluated as grade 1 adverse events. No grade 3 or 4 RCHs were observed. The time of onset of RCHs was dose dependent and shortest in the 400 mg-dose cohort(P < 0.001). Spontaneous and complete regression of RCHs was observed both during and after treatment. The objective response rate of tumors for patients with RCHs was 28.9%(24/83). However, no responders were observed among the patients without RCHs.Conclusions: RCHs were prevalent but manageable during treatment with SHR-1210. It might add to the expanding literature regarding immune-related dermatologic adverse events. | Xuelian Chen Lanying Ma Xi Wang Hongnan Mo Dawei Wu Bo Lan Dong Qu Hongtu Zhang Jing Huang Binghe Xu | 2019 | Cancer Biology & Medicine2019，16，1： | 53 |
| 2 | Characterization of the receptor-binding domain(RBD)of 2019 novel coronavirus:implication for development of RBD protein as a viral attachment inhibitor and vaccine显示文摘The outbreak of Coronavirus Disease 2019(COVID-19)has posed a serious threat to global public health,calling for the development of safe and effective prophylactics and therapeutics against infection of its causative agent,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),also known as 2019 novel coronavirus(2019-nCoV).The CoV spike(S)protein plays the most important roles in viral attachment,fusion and entry,and serves as a target for development of antibodies,entry inhibitors and vaccines.Here,we identified the receptor-binding domain(RBD)in SARS-CoV-2 S protein and found that the RBD protein bound strongly to human and bat angiotensin-converting enzyme 2(ACE2)receptors.SARS-CoV-2 RBD exhibited significantly higher binding affinity to ACE2 receptor than SARS-CoV RBD and could block the binding and,hence,attachment of SARS-CoV-2 RBD and SARS-CoV RBD to ACE2-expressing cells,thus inhibiting their infection to host cells.SARS-CoV RBD-specific antibodies could crossreact with SARS-CoV-2 RBD protein,and SARS-CoV RBD-induced antisera could cross-neutralize SARS-CoV-2,suggesting the potential to develop SARS-CoV RBD-based vaccines for prevention of SARS-CoV-2 and SARS-CoV infection. | Wanbo Tai Lei He Xiujuan Zhang Jing Pu Denis Voronin Shibo Jiang Yusen Zhou Lanying Du | 2020 | Cellular & Molecular Immunology2020，17，6： | 35 |
| 3 | The Hardy Rubber Tree Genome Provides Insights into the Evolution of Polyisoprene Biosynthesis显示文摘Eucommia ulmoides,也叫的强壮的橡胶树,是一棵经济地重要的树;然而,它的染色体顺序的缺乏 ?限制基本生物研究和这植物种的应用研究。这里,我们在场它的 1.2-Gb 染色体的一个高质量的集会(支架 N50 ?=? 1.88 Mb ) 与至少 26 ? 为 E 的 723 预言的基因。ulmoides,顺序 Garryales 的首先定序的染色体,它用联合定序的 Illumina 的综合策略被获得,定序的 PacBio,和印射的 BioNano。作为到 lamiids 和 campanulids 的姐妹 taxon, E。ulmoides 经历了三倍由核心 eudicots 而是没有进一步整个染色体的复制分享了的一个古老的染色体 ? 在最后 1.25 亿年里。E。ulmoides 为涉及压力回答和第二等的代谢物的生合成的多重基因展出高表达式层次或基因数字扩大,它可以说明它的可观的环境适应性。与橡胶树(Hevea brasiliensis ) 相对照,它生产 cis 聚异式戊二我烯, E。ulmoides 演变综合经由 farnesyl diphosphate synthases (FPS ) 的长链的 trans 聚异式戊二我烯。而且, FPS 和橡胶延伸 factor/small 橡胶粒子蛋白质基因家庭从 H 独立地被扩展。brasiliensis 系。这些结果提供新卓见进 E. 的生物学 ? ulmoides 和聚异式戊二我烯生合成的起源。 | Ta-na Wuyun Lin Wang Huimin Liu Xuewen Wang Liangsheng Zhang Jeffrey L. Bennetzen Tiezhu Li Lirong Yang Panfeng Liu Lanying Du Lu Wang Mengzhen Huang Jun Qing Iili Zhu Wenquan Bao Hongguo Li Qingxin Du Jingle Zhu Hong Yang Shuguang Yang Hui Liu Hui Yue Jiang Hu Suoliang Yu Yu Tian Fan Liang Jingjing Hu Depeng Wang Ruiwen Gao Dejun Li Hongyan Du | 2018 | Molecular Plant2018，11，3： | 24 |
| 4 | Study on the recovery of hydrogen from refinery (hydrogen+methane) gas mixtures using hydrate technology显示文摘A novel technique for separating hydrogen from (H2 + CH4) gas mixtures through hydrate formation/dissociation was proposed. In this work, a systematic experimental study was performed on the separation of hydrogen from (H2 + CH4) feed mixtures with various hydrogen contents (mole fraction x = 40%-90%). The experimental results showed that the hydrogen content could be enriched to as high as ~94% for various feed mixtures using the proposed hydrate technology under a temperature slightly above 0℃ and a pressure below 5.0 MPa. With the addition of a small amount of suitable additives, the rate of hydrate formation could be increased significantly. Anti-agglomeration was used to disperse hydrate particles into the condensate phase. Instead of preventing hydrate growth (as in the kinetic inhibitor tests), hydrates were allowed to form, but only as small dispersed particles. Anti-agglomeration could keep hydrate particles suspended in a range of condensate types at 1℃ and 5 MPa in the water-in-oil emulsion. | WANG XiuLin CHEN GuangJin YANG LanYing ZHANG LinWei | 2008 | Science China Chemistry2008，51，2： | 17 |
| 5 | Identification of an ideal adjuvant for receptor-binding domain-based subunit vaccines against Middle East respiratory syndrome coronavirus显示文摘 | Naru Zhang Rudragouda Channappanavar Cuiqing Ma Lili Wang Jian Tang Tania Garron Xinrong Tao Sumaiya Tasneem Lu Lu Chien-Te K Tseng Yusen Zhou Stanley Perlman Shibo Jiang Lanying Du | 2016 | Cellular & Molecular Immunology2016，13，2： | 12 |
| 6 | Precipitation seesaw phenomenon and its formation mechanism in the eastern and western parts of Northwest China during the flood season显示文摘Extending across three major plateaus,namely the Qinghai-Tibetan Plateau,the Inner Mongolia-Xinjiang Plateau and the Loess Plateau,Northwest China has the complex terrain and spatio-temporal climate variations,and is affected by the interactions among different circulation systems,such as the summer monsoon,the westerlies and the plateau monsoon.The understanding of the climate variability,as well as its characteristics and evolution mechanisms in this area has been limited so far.In this paper,the precipitation characteristics and mechanisms in the eastern and western parts of Northwest China during the flood season are compared and analyzed based on the data from 192 national meteorological observational sites in Northwest China in 1961-2016.The results show that,divided by the northern boundary of the East Asian summer monsoon,there are huge differences in the precipitation variation characteristics between the eastern and western parts.The inter-annual variations,interdecadal variations and total trends in the two parts all show a significant seesaw phenomenon.Moreover,it is found that the seesaw phenomenon of precipitation variation is closely related to the opposite variation between the East Asian summer monsoon index(MI)and the westerly circulation index(WI).In addition,the inverse variations on different time scales are only related to the contributions of precipitation at specific grades.Besides,in the two matching patterns of precipitation in the seesaw phenomenon,the middle and high latitudes are occupied by the'high-low-high'wave trains in the precipitation increases in the east of Northwest China(ENWC)and decreases in the west of Northwest China(WNWC)pattern,meaning precipitation increases in ENWC and decreases in WNWC.Whereas the opposite'low-high-low'wave trains at 500 hPa height are observed in the middle and high latitudes in the WH-EA pattern at 500 hPa height,meaning precipitation increases in WNWC and decreases in ENWC.Thus,the atmosphere circulation situation with two wave train types can support both the precipitation seesaw phenomenon and the opposite variation between MI and WI.Moreover,the seesaw phenomenon is shown to be related to the separate or joint effects of the South Asian High,ENSO and the plateau heating on the common but opposite effect on the summer monsoon and the westerlies,in which the South Asian High probably plays a more critical role.This study could deepen the scientific understanding of precipitation mechanisms and improve the weather forecast technology in Northwest China during the flood season. | Qiang ZHANG Jingjing LIN Weicheng LIU Lanying HAN | 2019 | Science China Earth Sciences2019，62，12： | 11 |
| 7 | Effect of Linguizhugan decoction on hyperlipidemia rats with intermittent fasting显示文摘OBJECTIVE:To explore the effect of Linguizhugan decoction on hyperlipidemia rats with caloric restriction.METHODS:The hyperlipidemia model of rat was induced by high fat diet for 8 weeks.After the model was established,26 rats were randomly divided into 4 groups:the control group(n=6),the model group(n=6),the intermittent fasting(IF) group(n= 8),and the IF and herbal medicine(IFH) group(n= 6).IF group was applied intermittent fasting every other day.The IFH group was given Linguizhugan decoction every day and intermittent fasting every other day.Blood samples were taken at the end of 16 weeks,and serum ghrelin and lipid was tested.RESULTS:Serum ghrelin in the IF group significantly increased(P<0.01).Serum ghrelin in IFH group was lower than the IF group(P<0.05),but higher than the model group(P<0.01).CONCLUSION:Linguizhugan decoction may play a part in regulation of energy and appetite in hyperlipidemia rats with IF. | Yubin Yang Jian Qin Bin Ke Junjie Zhang Lanying Shi Qiong Li | 2013 | Journal of Traditional Chinese Medicine2013，33，2： | 6 |
| 8 | A novel receptor-binding domain (RBD)-based mRNA vaccine against SARS-CoV-2显示文摘Dear Editor,The pandemic of coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)highlights the need to develop effective and safe vaccines.Similar to SARS-CoV,SARS-CoV-2 recognizes angiotensin-converting enzyme 2(ACE2)as receptor for host cell entry.1,2 SARS-CoV-2 spike(S)protein consists of S1,including receptor-binding domain(RBD),and S2 subunits.3,4 We previously demonstrated that RBDs of SARS-CoV and MERS-CoV serve as important targets for the development of effective vaccines. | Wanbo Tai Xiujuan Zhang Aleksandra Drelich Juan Shi Jason CHsu Larry Luchsinger Christopher D.Hillyer Chien-Te KTseng Shibo Jiang Lanying Du | 2020 | Cell Research2020，30，10： | 5 |
| 9 | Contaminant removal from low-concentration polluted river water by the bio-rack wetlands显示文摘The bio-rack is a new approach for treating low-concentration polluted river water in wetland systems.A comparative study of the efficiency of contaminant removal between four plant species in bio-rack wetlands and between a bio-rack system and control system was conducted on a small-scale (500 mm length × 400 mm width × 400 mm height) to evaluate the decontamination effects of four different wetland plants.There was generally a significant difference in the removal of total nitrogen (TN),ammonia nitrogen (NH 3-N) and total phosphorus (TP),but no significant difference in the removal of permanganate index (COD Mn) between the bio-rack wetland and control system.Bio-rack wetland planted with Thalia dealbata had higher nutrient removal rates than wetlands planted with other species.Plant fine-root (root diameter 3 mm) biomass rather than total plant biomass was related to nutrient removal efficiency.The study suggested that the nutrient removal rates are influenced by plant species,and high fine-root biomass is an important factor in selecting highly effective wetland plants for a bio-rack system.According to the mass balance,the TN and TP removal were in the range of 61.03-73.27 g/m2 and 4.14-5.20 g/m2 in four bio-rack wetlands during the whole operational period.The N and P removal by plant uptake constituted 34.9%-43.81% of the mass N removal and 62.05%-74.81% of the mass P removal.The study showed that the nitrification/denitrification process and plant uptake process are major removal pathways for TN,while plant uptake is an effective removal pathway for TP. | Ji Wang Lanying Zhang Shaoyong Lu Xiangcan Jint Shu Gan | 2012 | Journal of Environmental Sciences2012，24，6： | 4 |
| 10 | Construction of the Chinese Veteran Clinical Research (CVCR) Platform for the assessment of non-communicable diseases显示文摘 | Tan Jiping Li Nan Gao Jing Guo Yuhe Hu Wei Yang Jinsheng Yu Baocheng Yu Jianmin Du Wei Zhang Wenjun Cui Lianqi Wang Qingsong Xia Xiangnan Li Jianjun Zhou Peiyi Zhang Baohe Liu Zhiying Zhang Shaogang Sun Lanying Liu Nan Deng Ruixiang Dai Wenguang Yi Fang Chen Wenjun Zhang Yongqing Xue Shenwu Cui Bo Zhao Yiming Wang Luning | 2014 | Chinese Medical Journal2014，，3： | 3 |
| 11 | EFFECT OF LASER SCANNING SPEED ON PHASE CONSTITUTION AND WEAR RESISTANCE OF LASER CLADDING HARD FACING ALLOY STELLITE 12显示文摘Effect of laser scanning speed on phase constitution,microstructure,microhardness and wearresistance of laser-cladding hard facing alloy Stellite 12 has been investigated by means of across-flow-type CO2 laser of 1.5 kW.The laser-cladding layer on the alloy consists of ma-trix phase of suppersaturated solid solution γ(Co,Cr)and complex hexagonal carbideM7C3.Under certain condition,at higher laser scanning speed,the suppersaturated solubilityof elements increases in γ(Co,Cr),and the precipitation of the complex carbtde M7C3 de-creases,so the microhardness increases and the wear resistance decreases.But at slower laserscanning speed,more complex carbide M7C3 may precipitate,and the wear resistance may beimproved.Therefore,it is believed that the principal factor in improving wear resistance is theprecipitation of carbide M7C3,while increment of microhardness is the suppersaturated solu-bility of elements in matrix phase γ(Co,Cr). | XU Yourong ZHANG Henghua CHEN Darning XIE Fuchun XU Mingyu Shanghai University of Science and Technology,Shanghai,ChinaCHEN Lanying SU Baorong QIAN Hongbin Shanghai Optics and Fine Mechinery Research Institute,Academia Sinica,Shanghai,China XU Yourong,professor,Department of Materials Science and Engineering,Shanghai University of Science and Technology,Shanghai 201800,China | 1993 | Acta Metallurgica Sinica(English Letters)1993，6，5： | 3 |
| 12 | The trend of sand flux and the meteorology elements changes in the near-surface layer of Tengger desert in the spring of 2006显示文摘Dust storm events,especially those associated with strong winds,are immediately dangerous,and have long-term harmful effects.During a dust storm event,dust in the near-surface atmospheric layer decreases visibility,and changes local meteorological parameters.In this paper,we analyzed levels of near-surface turbulence during and outside a dust storm event and found differences in the degree of turbulence,with wind speed increasing and amounts of windblown sand greatly increasing air turbu-lence during the dust storms compared with the corresponding values on a sunny day.In addition,the wind profile during the dust storm deviated from the normal profile and became more complex.In the near-surface atmospheric layer,sand and dust flux during the dust storm also differed from those on a sunny day. | ZHANG ZhengCai DONG ZhiBao HAN LanYing ZHAO AiGuo | 2008 | Chinese Science Bulletin2008，53，21： | 2 |
| 13 | Neutralizing antibodies for the prevention and treatment of COVID-19显示文摘Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)initiates the infection process by binding to the viral cellular receptor angiotensin-converting enzyme 2 through the receptor-binding domain(RBD)in the S1 subunit of the viral spike(S)protein.This event is followed by virus–cell membrane fusion mediated by the S2 subunit,which allows virus entry into the host cell.Therefore,the SARS-CoV-2 S protein is a key therapeutic target,and prevention and treatment of coronavirus disease 2019(COVID-19)have focused on the development of neutralizing monoclonal antibodies(nAbs)that target this protein.In this review,we summarize the nAbs targeting SARS-CoV-2 proteins that have been developed to date,with a focus on the N-terminal domain and RBD of the S protein.We also describe the roles that binding affinity,neutralizing activity,and protection provided by these nAbs play in the prevention and treatment of COVID-19 and discuss the potential to improve nAb efficiency against multiple SARSCoV-2 variants.This review provides important information for the development of effective nAbs with broad-spectrum activity against current and future SARS-CoV-2 strains. | Lanying Du Yang Yang Xiujuan Zhang | 2021 | Cellular & Molecular Immunology2021，18，10： | 2 |
| 14 | Biochemical genetic structure and identification of hairtail fish(Trichiurus) populations in Chinese coastal waters显示文摘Biochemicalgeneticstructureandidentificationofhairtailfish(Trichiurus)populationsinChinesecoastalwaters￥WangKeling;ZhangPeiju... | Wang Keling Zhang Peijun Liu Lanying You Feng Liu Jing Xu Cheng and Wang Jianfei (Institute of Oceanology, Academia Sinica, Qingdao 266071, China) | 1994 | Acta Oceanologica Sinica1994，13，4： | 2 |
| 15 | Photocatalytic re- duction ofp-chloronitrobenzene on illuminated nano-titanium dio- dioxide particles 显示文摘 | Zhang Tianyong You Lanying Zhang Yonglan | 2006 | Dyes and Pigments2006，68，23： | 1 |
| 16 | Carrier concentration profiling in magnetic GaMnSb/GaSb investigated by electrochemistry capacitance-voltage profiler显示文摘Depth profiles of carrier concentrations in Ga-MnSb/GaSb are investigated by electrochemistry capacitance-voltage profiler and electrolyte of Tiron. The carrier concentration in GaMnSb/GaSb measured by this method is coincident with the results of Hall and X-ray diffraction measurements. It is indicated that most of the Mn atoms in GaMnSb take the site of Ga, play a role of acceptors, and provide shallow acceptor level(s). | ZHANG Xiulan ZHANG Fuqiang SONG Shulin CHEN Nuofu WANG Zhanguo LIN Lanying | 2002 | Chinese Science Bulletin2002，47，21： | 1 |
| 17 | A novel DSPP mutation is associated with type dentinogenesis imperfecta in a chinese family 显示文摘 | Zhang Xianqin Chen Lanying Liu Jingyu | 2007 | BMC Medical Genetics2007，52，8： | 1 |
| 18 | Synthesis and Spectral Properties of Novel Water-soluble Indocyanine Dyes as Fluorescent Dyes for Proteins Detection显示文摘二新奇水溶性的 indocyanine 染料被综合。他们的化学结构被 1H NMR,红外, MS 和紫外力的技术证实。在不同溶剂的准备染料的吸收被测量。二染料展出了否定 solvatochromism,与吸收和排放最大值在的蓝移动(牛的浆液白朊) protonic 溶剂相对非 protonic 溶剂。处于免费状态和 BSA 的染料的荧光性质被调查。为 Dye2 的荧光紧张的重要改进面对 BSA 被观察。Dye2 能作为荧光灯被建议为在水的答案的 BSA 察觉的染料。 | Fu, Yile Wang, Lanying Zhang, Xianghan Lu, Tianqin Xie, Qianjie Shi, Zhen | 2011 | Chinese Journal of Chemistry2011，29，3： | 1 |
| 19 | Antagonistic actions of Msxl and Osr2 pattern mammalian teeth into a single row 显示文摘 | Zhang Z LanY Chai Y | 2009 | Science2009，323，5918： | 1 |
| 20 | MICROSTRUCTURE OF A RAPIDLY SOLIDIFIED Fe-C-Sn ALLOY显示文摘The microstructure of a laser-melted Fe-4% C-10% Sn alloy has been studied.Anon-crystalline phase was found in the upper part of the laser-melted zone:At the bottom ofthe melted zone,however,the microcrystalline zone which consists of α-Fe and a bet phasewas observed.Fine twinning martensite exists in the other area of the melted zone. | ZHANG Jingguo ZHANG Xiaomin LIN Yijian Shanghai Iron and Steel Research Institute,Shanghai,ChinaKE Jun (T.Ko) University of Iron and Steel Technology Beijing,Beijing,ChinaCHEN Lanying Shanghai Institute of Optic and Fine Mechanics,Academic Sinica,Shanghai,China Senior Engineer,Shanghai Iron and Steel Research Institute,Shanghai 200940,China | 1989 | Acta Metallurgica Sinica(English Letters)1989，2，5： | 1 |
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