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| 1 | The First Imported Case of Monkeypox in the Mainland of China—Chongqing Municipality,China,September 16,2022显示文摘Monkeypox is a zoonotic viral disease caused by the monkeypox virus(MPXV),and historically,all outbreaks have been linked to Africa;however,monkeypox has been posing an alarming challenge to the world in 2022(1)as approximately 60,000 cases have been reported in more than 100 nations and regions worldwide(2).Currently,many cases of monkeypox were identified in many nonendemic countries outside of Central and West Africa,and human-to-human transmission has occurred frequently,especially among men who have sex with men(MSM)presenting new clinical symptoms similar to syphilis and other sexually transmitted infections(3). | Hua Zhao Wenling Wang Li Zhao Sheng Ye Jingdong Song Roujian Lu Hua Zong Changcheng Wu Wei Huang Baoying Huang Yao Deng Ruhan A Wujuan Xie Li Qi Wenbo Xu Hua Ling Wenjie Tan | 2022 | China CDC weekly2022，4，38： | 35 |
| 2 | Thinning and Shrinkage of Laohugou No. 12 Glacier in the Western Qilian Mountains, China, from 1957 to 2007显示文摘Landsat images, real-time kinematic GPS measurements, and topographic maps were used to determine changes in ice elevation, volume, and areal extent of the Laohugou No. 12 glacier (Qilian Mountains, China) between 1957 and 2007. The glacier experienced significant thinning and areal shrinkage in the ablation zone, but slight thickening in part of the accumulation zone. Elevation decreased by 18.6±5.4 m between 1957 and 2007 in the regions covered by the GPS measurements. The total volume loss for the entire glacier was estimated to be 0.218 km3 using a third-order polynomial fit method. The area diminished by 0.28 km2 between 1957 and 1994, 0.26 km2 between 1994 and 2000, and 0.28 km2 between 2000 and 2007, suggesting that the rate of loss in glacial coverage has increased since the mid-1990s. Significant increases in annual mean air temperature may have contributed to shrinkage and thinning of the glacier. | ZHANG Yingsong LIU Shiyin SHANGGUAN Donghui LI Jing ZHAO Jingdong | 2012 | Journal of Mountain Science2012，9，3： | 16 |
| 3 | Multifunctional polymeric micelle-based chemo-immunotherapy with immune checkpoint blockade for efficient treatment of orthotopic and metastatic breast cancer显示文摘Immunotherapy has become a highly promising paradigm for cancer treatment. Herein, a chemo-immunotherapy was developed by encapsulating chemotherapeutic drug doxorubicin(DOX) and Toll-like receptor 7 agonist imiquimod(IMQ) in low molecular weight heparin(LMWH)-D-α-tocopheryl succinate(TOS) micelles(LT). In this process, LMWH and TOS were conjugated by ester bond and they were not only served as the hydrophilic and hydrophobic segments of the carrier, but also exhibited strong anti-metastasis effect. The direct killing of tumor cells mediated by DOX-loaded micelles(LT-DOX)generated tumor-associated antigens, initiating tumor-specific immune responses in combination with IMQ-loaded micelles(LT-IMQ). Furthermore, the blockade of immune checkpoint with programmed cell death ligand 1(PD-L1) antibody further elevated the immune responses by up-regulating the maturation of DCs as well as the ratios of CD8+ CTLs/Treg and CD4+ Teff/Treg. Therefore, such a multifunctional strategy exhibited great potential for inhibiting the growth of orthotopic and metastatic breast cancer. | Jiaojie Wei Yang Long Rong Guo Xinlei Liu Xian Tang Jingdong Rao Sheng Yin Zhirong Zhang Man Li Qin He | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 8 |
| 4 | Effects of High-temperature Char Layer and Pyrolysis Gas on NOx Reduction in a Typical Decoupling Combustion Coal-fired Stove显示文摘The suppression of nitrogen oxides(NO_x) is the key to reducing pollutant emission of a domestic coal-fired stove due to the limitation of technology condition and economic cost. The decoupling combustion(DC) technology invented by Institute of Process Engineering(IPE), Chinese Academy of Sciences(CAS) is characterized by that a traditional stove is separated into a pyrolysis and a combustion chamber as well as a bottom passage between them. In this study, the combustion of briquette from bituminous coal in different operation modes in a typical decoupling stove is tested and simulated to validate the advantage of DC technology over so-called reverse combustion. The smokeless and high-efficiency combustion of bituminous briquette with low emissions of NO_x and CO can be implemented by utilizing low NO_x combustion under low temperature and reduction atmosphere in the pyrolysis chamber as well as after-combustion of char and pyrolysis gas under high temperature and oxidation atmosphere in the combustion chamber. The effects of the main reducing components in pyrolysis gas as well as char on NO_x reduction were numerically investigated in this study, which shows that the reducing ability increases gradually from CH_4, CO to char, but the combined reducing ability of them cannot be determined by a simple addition. | LI Honglin HAN Jian ZHANG Nan LIU Xinhua HE Jingdong DU Wei | 2019 | Journal of Thermal Science2019，28，1： | 8 |
| 5 | Description of the First Strain of 2019-nCoV,C-Tan-nCoV Wuhan Strain-National Pathogen Resource Center,China,2020显示文摘The recent outbreak of novel coronavirus-infected pneumonia(NCIP)in China(1)has attracted much attention domestically and internationally.As the outbreak occurred,China carried out emergency responses quickly,notified the World Health Organization(WHO)in a timely manner,and shared the viral gene sequence with international communities immediately after pathogenic identification. | Qiang Wei Yanhai Wang Juncai Ma Jun Han Mengnan Jiang Li Zhao Fei Ye Jingdong Song Bo Liu Linhuan Wu Wenjie Tan Guizhen Wu George FGao Jianjun Liu | 2020 | China CDC weekly2020，2，6： | 5 |
| 6 | Selenium deficiency induces spleen pathological changes in pigs by decreasing selenoprotein expression,evoking oxidative stress,and activating inflammation and apoptosis显示文摘Background:The immune system is one aspect of health that is affected by dietary selenium(Se)levels and selenoprotein expression.Spleen is an important immune organ of the body,which is directly involved in cellular immunity.However,there are limited reports on Se levels and spleen health.Therefore,this study established a Se-deficient pig model to investigate the mechanism of Se deficiency-induced splenic pathogenesis.Methods:Twenty-four pure line castrated male Yorkshire pigs(45 days old,12.50±1.32 kg,12 full-sibling pairs)were divided into two equal groups and fed Se-deficient diet(0.007 mg Se/kg)or Se-adequate diet(0.3 mg Se/kg)for 16 weeks.At the end of the trial,blood and spleen were collected to assay for erythroid parameters,the osmotic fragility of erythrocytes,the spleen index,histology,terminal deoxynucleotidyl transferase nick-end labeling(TUNEL)staining,Se concentrations,the selenogenome,redox status,and signaling related inflammation and apoptosis.Results:Dietary Se deficiency decreased the erythroid parameters and increased the number of osmotically fragile erythrocytes(P<0.05).The spleen index did not change,but hematoxylin and eosin and TUNEL staining indicated that the white pulp decreased,the red pulp increased,and splenocyte apoptosis occurred in the Se deficient group.Se deficiency decreased the Se concentration and selenoprotein expression in the spleen(P<0.05),blocked the glutathione and thioredoxin antioxidant systems,and led to redox imbalance.Se deficiency activated the NF-κB and HIF-1αtranscription factors,thus increasing pro-inflammatory cytokines(IL-1β,IL-6,IL-8,IL-17,and TNF-α),decreasing anti-inflammatory cytokines(IL-10,IL-13,and TGF-β)and increasing expression of the downstream genes COX-2 and iNOS(P<0.05),which in turn induced inflammation.In addition,Se-deficiency induced apoptosis through the mitochondrial pathway,upregulated apoptotic genes(Caspase3,Caspase8,and Bak),and downregulated antiapoptotic genes(Bcl-2)(P<0.05)at the mRNA level,thus verifying the results of TUNEL staining.Conclusions:These results indicated that Se deficiency induces spleen injury through the regulation of selenoproteins,oxidative stress,inflammation and apoptosis. | Shuang Li Wenjuan Sun Kai Zhang Jiawei Zhu Xueting Jia Xiaoqing Guo Qingyu Zhao Chaohua Tang Jingdong Yin Junmin Zhang | 2021 | Journal of Animal Science and Biotechnology2021，12，4： | 4 |
| 7 | Identification of Histoplasma causing an unexplained disease cluster in Matthews Ridge, Guyana显示文摘Here,we report the identification of Histoplasma causing an unexplained disease cluster in Matthews Ridge,Guyana.In March 2019,14 employees of Chongqing Bosai Mining Company,China,working in a manganese mining of Guyana,had unexplained fever,and two of them died.We obtained lung and brain tissues as well as the blood samples from the two deceased cases(patient No.1 and 2),and bronchoscopy lavages and cerebrospinal fluid samples from one severe case(patient No.3),respectively.All samples were tested by pathological examination,high-throughput sequencing,and real-time PCR.Pathological detection showed the presence of spore-like structures in the lung tissue of patient No.1,indicating a fungal infection in this patient.Nanopore sequencing identified the existing of H.capsulatum in the lung tissue sample within 13 h.Next-generation sequencing identified specific fragments of H.capsulatum in all of the samples tested(lung,brain and blood serum from the deceased cases,and plasma from the severe case).Real-time PCR assays did not reveal any viral infection related to transmission from bat feces.We conclude that H.capsulatum was the causative pathogen of this disease cluster based on epidemiologic,clinical,pathological and nucleic acid evidence. | Ji Wang Weimin Zhou Hua Ling Xiaoping Dong Yi Zhang Jiandong Li Yong Zhang Jingdong Song William J.Liu Yang Li Ruiqing Zhang Wei Zhen Kun Cai Shuangli Zhu Dongyan Wang Jinbo Xiao Yigang Tong Wenli Liu Lihua Song Wei Wu Yang Liu Xiang Zhao Ruihuan Wang Sheng Ye Jing Wang Roujian Lu Baoying Huang Fei Ye Wenwen Lei Rongbao Gao Qi Shi Cao Chen Jun Han Wenbo Xu George F.Gao Xuejun Ma Guizhen Wu | 2019 | Biosafety and Health2019，1，3： | 3 |
| 8 | Approach and potential of replacing oil and natural gas with coal in China显示文摘China’s fossil energy is characterized by an abundance of coal and a relative lack of oil and natural gas.Developing a strategy in which coal can replace oil and natural gas is,therefore,a necessary and practical approach to easing the excessive external dependence on oil and natural gas.Based on the perspective of energy security,this paper proposes a technical framework for defining the substitution of oil and natural gas with coal in China.In this framework,three substitution classifications and 11 industrialized technical routes are reviewed.Then,three scenarios(namely,the cautious scenario,baseline scenario,and positive scenario)are developed to estimate the potential of this strategy for 2020 and 2030.The results indicate that oil and natural gas replaced by coal will reach 67 to 81 Mt and 8.7 to 14.3 Gm^3 in 2020 and reach 93 to 138 Mt and 32.3 to 47.3 Gm^3 in 2030,respectively.By implementing this strategy,China’s external dependence on oil,natural gas,and primary energy is expected to be curbed at approximately 70%,40%,and 20%by 2030,respectively.This paper also demonstrates how coal,as a substitute for oil and natural gas,can contribute to carbon and pollution reduction and economic cost savings.It suggests a new direction for the development of the global coal industry and provides a crucial reference for energy transformation in China and other countries with similar energy situations. | Junjie LI Yajun TIAN Xiaohui YAN Jingdong YANG Yonggang WANG Wenqiang XU Kechang XIE | 2020 | Frontiers in Energy2020，14，2： | 3 |
| 9 | Isolation and Characterization of Monkeypox Virus from the First Case of Monkeypox—Chongqing Municipality,China,2022显示文摘Introduction:The first imported case of monkeypox(MPX)from the mainland of China was reported in September 2022.Herein,the study reports the isolation and characterization of MPX virus(MPXV)in this case.Methods:Clinical specimens including skin blister fluid,oropharyngeal and nasopharyngeal swabs,and blood were collected and inoculated onto Vero cells.The isolated virus was identified as MPXV using quantitative polymerase chain reaction(qPCR),cytopathic effects(CPEs),immunofluorescence assay(IFA)and transmission electron microscopy(TEM).Plaque assays were employed to quantify infectious plaque-forming units(PFUs).The plaque reduction neutralization test(PRNT)was developed to determine the neutralizing antibody(nAb)against MPXV.Results:MPXV replication was confirmed with qPCR.Typical CPEs were observed 48 h postincubation.The isolated virus was named MPXV-B.1-China-C-Tan-CQ01.IFA showed that MPXV reacted with serum of MPX case.Orthopoxvirus morphology was observed using TEM.The virus titer increased to>106 PFU/mL after three passages.The serum PRNT 50%neutralization titer(NT50)was 35 for the MPX patient 6 days after symptom onset.Discussion:The study successfully isolated the first MPXV strain in the mainland of China,MPXV-B.1-China-C-Tan-CQ01.Infectious titration and PRNT methods have been developed.The study provides key resources and technical platforms for further research as well as anti-viral drug and vaccine development against MPX. | Baoying Huang Hua Zhao Jingdong Song Li Zhao Yao Deng Wen Wang Roujian Lu Wenling Wang Jiao Ren Fei Ye Houwen Tian Guizhen Wu Hua Ling Wenjie Tan | 2022 | China CDC weekly2022，4，46： | 3 |
| 10 | Mechanism of improved electromigration reliability using Fe-Ni UBM in wafer level package显示文摘Fe-Ni films with compositions of 73 wt% of Ni and 45 wt% of Ni were used as under bump metallization(UBM) in wafer level chip scale package,and their reliability was evaluated through electromigration(EM)test compared with commercial Cu UBM.For Sn3.8 Ag0.7 Cu(SAC)/Cu solder joints,voids had initiated at Cu cathode after 300 h and typical failures of depletion of Cu cathode and cracks were detected after 1000 h EM.While the SAC/Fe-Ni solder joints kept at a perfect condition without any failures after 1000 h EM.Moreover,the characteristic lifetime calculated by Weibull analysis for Fe-73 Ni UBM(2121 h),Fe-45 Ni UBM(2340 h) were both over three folds to Cu UBM's(698 h).The failure modes for Fe-Ni solder joints varied with the different growth behavior of intermetallic compounds(IMCs),which can all be classified as the crack at the cathodic interface between solder and outer IMC layer.The atomic fluxes concerned cathode dissolution and crack initiation were analyzed.When Fe-Ni UBM was added,cathode dissolution was suppressed due to the low diffusivity of IMCs and opposite transferring direction to electron flow of Fe atoms.The smaller EM flux within solder material led a smaller vacancy flux in Fe-Ni solder joints,which can explain the delay of solder voids and cracks as well as the much longer lifetime under EM. | Li-Yin Gao Hao Zhang Cai-Fu Li Jingdong GUO Zhi-Quan Liu | 2018 | Journal of Materials Science & Technology2018，34，8： | 3 |
| 11 | Temporal variation of major nutrients and probabilistic eutrophication evaluation based on stochastic-fuzzy method in Honghu Lake, Middle China显示文摘Honghu Lake, which is listed in the Ramsar Convention, was found to be contaminated with elevated nutrients to a certain extent.This study investigated the seasonal variation of major nutrients and probabilistic eutrophic state in surface water from Honghu Lake. Average concentrations of total nitrogen(TN), total phosphorus(TP), chlorophyll-a(Chl-a), chemical oxygen demand(COD_(Mn)) and transparency(SD) in summer and winter generally exceeded Grade III of the Chinese environmental quality standards for surface water(GB 3838-2002), with the exception of COD_(Mn)in winter. Mean concentrations of Chl-a and COD_(Mn) in summer were higher than that in winter, while mean concentrations of TN, TP and SD were slightly higher in winter. The improved probabilistic comprehensive trophic level index(PTLI) method based on stochastic-fuzzy theory was established to evaluate the eutrophic state in Honghu Lake. Compared with the Monte-Carlo sampling method, the Latin Hypercube sampling(LH-TFN) method was selected for the evaluation simulation due to its efficiency and stability. Evaluation results indicated that mean PTLI in summer(69.70) and winter(61.96) were both subordinated to Grade IV(Medium eutrophication). The corresponding reliability of eutrophication level subordinating to Grade IV in summer was of relatively low reliability(51.27%),which might mislead decision makers to some extent and suggest recheck. The probabilistic eutrophication level in summer developed with a trend from medium to severe eutrophication. Sensitivity analysis illustrated that COD_(Mn)and Chl-a were the priority pollutants in summer, with the contributions to PTLI of 43.3% and 22.5% respectively. Chl-a was the priority pollutant in winter, with the contribution to PTLI up to 51.3%. | LI Fei QIU ZhenZhen ZHANG JingDong LIU ChaoYang CAI Ying XIAO MinSi ZHU LiYun | 2019 | Science China(Technological Sciences)2019，62，3： | 2 |
| 12 | Joint salient object detection and existence prediction显示文摘Recent advances in supervised salient object detection modeling has resulted in significant performance improvements on benchmark datasets. However, most of the existing salient object detection models assume that at least one salient object exists in the input image. Such an assumption often leads to less appealing saliency maps on the background images with no salient object at all. Therefore, handling those cases can reduce the false positive rate of a model. In this paper, we propose a supervised learning approach for jointly addressing the salient object detection and existence prediction problems. Given a set of background-only images and images with salient objects, as well as their salient object annotations, we adopt the structural SVM framework and formulate the two problems jointly in a single integrated objective function: saliency labels of superpixels are involved in a classification term conditioned on the salient object existence variable, which in turn depends on both global image and regional saliency features and saliency labels assignments. The loss function also considers both image-level and regionlevel mis-classifications. Extensive evaluation on benchmark datasets validate the effectiveness of our proposed joint approach compared to the baseline and state-of-the-art models. | Huaizu JIANG Ming-Ming CHENG Shi-Jie LI Ali BORJI Jingdong WANG | 2019 | Frontiers of Computer Science2019，13，4： | 2 |
| 13 | Ultrastructural characterization of avian influenza A(H7N9) virus infecting humans in China显示文摘Dear Editor,In March 2013,the first 3 cases of severe disease dueto a novel avian-origin influenza A(H7N9)virus weredetected in the Chinese provinces of Shanghai and Anhui(Gao R,et al.,2013).A total of 339 laboratory-confirmedcases with 100 deaths were reported until January 142014(WHO,2014).To the best of our knowledge,thisis the first time that human infection with the avian in-fluenza A H7N9 subtype has been detected.Prior to | Rongbao Gao Jingdong Song Ye Zhang Shumei Zou Tian Bai Xiaodan Li Jianguo Qu Jianfang Zhou Tao Hung Yuelong Shu | 2014 | Virologica Sinica2014，29，2： | 2 |
| 14 | Experi- mental research on the robotic compound polishing process with mixed magnetic abrasive显示文摘 | Han Guangchao Sun Ming Li Jingdong | 2010 | Advanced Materials Research2010，，129131： | 1 |
| 15 | Molecular mechanism for the substrate recognition of USP7显示文摘 | Jingdong Cheng (1) (2) Ze Li (1) (2) Rui Gong (1) Jian Fang (1) Yi Yang (1) Chang Sun (1) Huirong Yang (1) Yanhui Xu (1) (2) (3) | 2015 | Protein & Cell2015，6，11： | 1 |
| 16 | Conceptual de- sign of the cryogenic system for a 12 MW superconducting wind turbine generator显示文摘 | HE Jie TANG Yuejin LI Jingdong | 2014 | IEEE Transactions on Applied Superconductivity2014，24，3： | 1 |
| 17 | The first strain of monkeypox isolated in the Chinese Mainland and preserved at the National Pathogen Resource Center of China显示文摘On September 16,2022,the first imported monkeypox case was reported in the Chinese Mainland.Laboratory tests including nucleic acid detection were carried out in Chongqing Nan’an Centre for Disease Control and Prevention and Chongqing Center for Disease Control and Prevention.After that,monkeypox virus was isolated by the Institute for Viral Disease Control and Prevention and preserved at the National Pathogen Resource Center on September 18,2022.The National Pathogen Resource Center shared the basic information of monkeypox virus strain,samples,biosafety,strain imaging,RT-PCR primers,and probes sequence timely to support the prevention and control of monkeypox epidemic and facilitate the scientific research on vaccine development,drug screening and evaluation of monkeypox virus in the future. | Qiang Wei Baoying Huang Wei Huang Jingdong Song Li Mei Li Zhao Jing Yin Juan Zhang Wenling Wang Fei Ye Caiyun Li Liling Bai Yanhai Wang Yao Deng Bo Liu Mengnan Jiang Guizhen Wu Jun Han Hua Zhao Hua Ling Wenjie Tan Jianjun Liu | 2022 | Infectious Medicine2022，1，4： | 1 |
| 18 | The mTOR pathway is associated with the poor prognosis of human hepatocellular carcinoma显示文摘 | Ledu Zhou Yun Huang Jingdong Li Zhiming Wang | 2010 | Medical Oncology2010，，2： | 1 |
| 19 | Discovering conserved insect microRNAs from expressed sequence tags显示文摘 | Qidong Jia Kejian Lin Jingdong Liang Lun Yu Fei Li | 2010 | Journal of Insect Physiology2010，，12： | 1 |
| 20 | Neuroprotective effect of morroniside on focal cerebral ischemia in rats显示文摘 | Wen Wang Jingdong Xu Lei Li Peichang Wang Xunming Ji Houxi Ai Li Zhang Lin Li | 2010 | Brain Research Bulletin2010，，5： | 1 |
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