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| 1 | Expression,deleton and mnutation of ρ16 gene in human gastric cancer显示文摘AIM To investigate the relationship between the expression of p16 gene and the gastric carcinogenesis,depth of invasion and lymph node metastases, and to evaluate the deletion and mutation of exon 2 in p16 gene in gastric carcinoma.METHODS The expression of P16 protein was examined by streptavidin-peroxidase conjugated method (S-P); the deletion and mutation of p16 gene were respectively examined by polymerase chain reaction (PCR) and polymerase chain reaction single-strand conformation polymorphism analysis (PCR-SSCP) in gastric carcinoma.RESULTS Expression of P16 protein was detected in 96.25% (77/80) of the normal gastric mucosa, in 92.00% (45/50) of the dysplastic gastric mucosa and in 47.54% (58/122) of the gastric carcinoma. The positive rate of P16 protein expression in gastric carcinoma was significantly lower than that in normal gastric mucosa and dysplastic gastric mucosa (P<0.05). The positive rate of P16 protein expression in mucoid carcinoma 10.00% (1/ 10) was significantly lower than that in poorly differentiated carcinoma 51.22% ( 21/ 41 ),undifferentiated carcinoma 57.69% (15/26) and signet ring cell carcinoma 62.50% (10/ 16) (P<0.05). The positive rate of p16 protein in 30 cases paired primary and lymph node metastatic gastric carcinoma: There was 46.67% (14/30) in primary gastric carcinoma, 16.67% (5/30) in lymph node metastatic gastric carcinoma. The positive rate of lymph node metastatic carcinoma was significantly lower than that of primary carcinoma (P<0.05). There was of p16 gene mutation in exon 2, but 5 cases displayed deletion of p16 gene in exon 2 in the 25 primary gastric carcinomas.CONCLUSIONS The expression loss of P16 protein related to the gastric carcinogenesis, gastric carcinoma histopathological subtypes and lymph metastasis. The mutation of p16 gene in exon 2 may not be involved in gastric carcinogenesis. But the deletion of p16 gene in exon 2 may be involved in gastric carcinogenesis. | Xiu-Sheng He Qi Su Zhu-Chu Chen Xiu-Tao He Zhi-Feng Long Hui Ling Liang-Run Zhang Oncology Institute,Nanhua University,Hengyang 421001,Hunan Province,ChinaOncology Institute,Center South University,Changsha 410078,Hunan Province,China Department of Gastroenterology,First People’s Hospital of Changde City,Changde 415003,Hunan Province,China | 2001 | World Journal of Gastroenterology2001，7，4： | 40 |
| 2 | TGF-β signaling in cancer metastasis显示文摘转变生长因素(TGF )- 发信号的事件是众所周知的控制多样的进程和众多的回答例如房间增长,区别, apoptosis,和移植。在癌症的 TGF- 发信号戏上下文依赖者角色:在 pre 恶意的房间, TGF- 首先作为肿瘤 suppressor 工作,当在癌症的以后的阶段发信号的 TGF- 支持侵略和转移时。最近的研究也建议了在 TGF- 发信号和另外的发信号的小径之间的串音例如河马, Wnt, EGFR/RAS,和 PI3K/AKT 小径,可以实质地贡献我们 TGF- 发信号和癌症的当前的理解。由于 TGF- 的广阔效果, TGF- 和它的下游的发信号部件的封锁提供多重治疗学的机会。因此,为为众多的疾病表明治疗的 anti-TGF- 的眼界显得明亮并且将提供珍贵信息并且想在这药上分子的设计。在这评论,我们集中于最近的卓见进在可以贡献新奇指向癌症的治疗的发展的癌症转移发信号的 TGF- 的规定。 | Feng Xie Li Ling Hans van Dam Fangfang Zhou Long Zhang | 2018 | Acta Biochimica et Biophysica Sinica2018，50，1： | 36 |
| 3 | Detection of HBV DNA and its existence status in liver tissues and peripheral blood lymphocytes from chronic hepatitis B patients显示文摘INTRODUCTIONCumulativeclinicalandexperimentalevidenceindicatesthathostimmuneresponsestohepatitisBvirus(HBV)areresponsibleforl... | TANG Ren Xian, GAO Feng Guang, ZENG Ling Yu, WANG Ying Wei and WANG Yu Long | 1999 | World Journal of Gastroenterology1999，5，4： | 27 |
| 4 | Effect of dietary supplementation with protease on growth performance,nutrient digestibility, intestinal morphology, digestive enzymes and gene expression of weaned piglets显示文摘This study was conducted to investigate the effect of dietary protease supplementation on the growth performance, nutrient digestibility, intestinal morphology, digestive enzymes and gene expression in weaned piglets. A total of 300 weaned piglets(21 days of age Duroc x Large White x Landrace; initial BW = 6.27 ± 0.45 kg) were randomly divided into 5 groups. The 5 diets were: 1) positive control diet(PC), 2) negative control diet(NC), and 3) protease supplementations, which were 100, 200, and 300 mg per kg NC diet. Results indicated that final BW, ADG, ADFI, crude protein digestibility, enzyme activities of stomach pepsin, pancreatic amylase and trypsin, plasma total protein, and intestinal villus height were higher for the PC diet and the supplementations of 200 and 300 mg protease per kg NC diet than for the NC diet(P < 0.05). Supplementations of 200 and 300 mg protease per kg NC diet significantly increased the ratio of villus height to crypt depth(VH:CD) of duodenum, jejunum and ileum compared with NC diet(P < 0.05). Feed to gain ratio, diarrhea index, blood urea nitrogen, and diamine oxidase were lower for the PC diet and supplementations of 200 and 300 mg protease per kg NC diet than for the NC diet(P < 0.05). Piglets fed the PC diet had a higher peptide transporter 1(PepTl) mRNA abundance in duodenum than piglets fed the NC diet(P < 0.05), and supplementations of 100, 200 and 300 mg protease per kg NC diet increased the PepTl mRNA abundance in duodenum(P < 0.05) comparing with the NC diet. Piglets fed the PC diet had a higher b0,+AT mRNA abundance in jejunum than piglets fed the NC diet(P < 0.05), and supplementations of 200 and 300 mg protease per kg NC diet increased the b0,+AT mRNA abundance in jejunum and ileum comparing with the NC diet(P < 0.05). In summary, dietary protease supplementation increases growth performance in weaned piglets, which may contribute to the improvement of intestinal development, protein digestibility, nutrient transport efficiency, and health status of piglets when fed low digestible protein sources. | Jianjun Zuo Baoming Ling Lina Long Tiejun Li Ludovic Lahaye Chengbo Yang Dingyuan Feng | 2015 | Animal Nutrition2015，，4： | 18 |
| 5 | Effect of Seawater Stress on Physiological and Biochemical Responses of Five Jerusalem Artichoke Ecotypes显示文摘Three treatments consisting of 0%,15%,and 30%seawater were investigated to analyse the ecotypic variabilities among five populations of Jerusalem artichoke(Helianthus tuberosus)regarding their responses to seawater stress under a hydroponic culture system.Analyses were done 2,4,and 6 days after treatments.The 15%and 30%seawater treatments reduced the growth rates of roots and shoots of H.tuberosus populations.The activities of superoxide dismutase, peroxidase,and catalase majored in the leaves were stimulated under the seawater stress.The electrolyte leakage and malondialdehyde contents of the leaves were also stimulated owing to seawater stress.The contents of proline and soluble- sugars in the leaves increased significantly with increasing seawater concentrations.The concentrations of Na+,K+,and Cl-in the aerial parts and roots increased with an increase in the seawater concentration throughout the experimental period.There were ecotypic differences among the five populations of H.tuberosus as evidenced by the analyses of the above items in both aerial parts and roots under seawater treatment.The magnitude of the ecotypic variance components indicated that a substantial proportion of the total variation for these physiological and biochemical responses were owing to ecotype,indicating the possibility of improvement through hybridization and selection. | LONG Xiao-Hua CHI Jin-He LIU Ling LI Qing LIU Zhao-Pu | 2009 | Pedosphere2009，19，2： | 15 |
| 6 | Effect of endotoxin on fibronectin synthesis of rat primary cultured hepatocytes显示文摘EfectofendotoxinonfibronectinsynthesisofratprimaryculturedhepatocytesJIAJinBin,HANDeWu,XURuiLing,GAOFei,ZHAOLongFeng,ZHA... | JIA JinBin, HAN DeWu, XU RuiLing, GAO Fei, ZHAO LongFeng, ZHAO YuanChang, YAN JinPin and MA XueHuiKeywords liver cirrhosis endotoxins fibronectin/analysis liver/cytology cells, cultured lipopolysaccharide | 1998 | World Journal of Gastroenterology1998，4，4： | 14 |
| 7 | Rapid Detection and Identification of Infectious Pathogens Based on High-throughput Sequencing显示文摘 | Pei-Xiang Ni Xin Ding Yin-Xin Zhang Xue Yao Rui-Xue Sun Peng Wang Yan-Ping Gong Jia-Li Zhou Dong-Fang Li Hong-Long WO Xin Yi Ling Yang Yun Long | 2015 | Chinese Medical Journal2015，，7： | 13 |
| 8 | Laparoscopic hepaticoplasty using gallbladder as a subcutaneous tunnel for hepatolithiasis显示文摘AIM:To investigate the feasibility,efficacy and safety of laparoscopic hepaticoplasty using gallbladder as subcutaneous tunnel and sphincter-of-Oddi preservation for hepatolithiasis.METHODS:From January 2010 to July 2013,six patients with hepatolithiasis were treated at our institution.All the patients underwent laparoscopic surgery.The procedures included common hepatic duct exploration,stone clearance by fiberoptic choledochoscopy,hilar bile duct hepaticoplasty with preservation of the sphincter of Oddi,anastomosis between the hilar bile duct and neck of the gallbladder,and establishment of a subcutaneous tunnel with the gallbladder.Two patients underwent left lateral hepatectomy simultaneously.Clinical data including operation time,intraoperative blood loss,operative morbidity,hospital mortality,stone clearance,and recurrence rate were analyzed.RESULTS:All patients successfully completed laparoscopic surgery.The mean length of hospital stay was4.5±0.9 d(range:3-6 d).The mean blood loss of the hepatectomy was 450 mL(range:200-700 mL),and the blood loss of the other four was 137±151 mL (range:50-400 mL).The mean operative time was 318±68 min(range:236-450 min).The operative morbidity and hospital mortality were zero.The immediate stone clearance rate was 100%.All patients were followed up for an average of 17 mo(range:7-36 mo).One of the six patients had abdominal mass with pain,and subcutaneous tunnel cholangiography showed severe gallbladder-biliary anastomotic stricture at 4 mo postoperatively.There was no stone recurrence and no cholangitis during follow-up.CONCLUSION:Laparoscopic hepaticoplasty using gallbladder with a subcutaneous tunnel and preserving the sphincter of Oddi is feasible,safe and effective for hepatholithiasis. | Long Cui Zhi Xu Xiao-Feng Ling Li-Xin Wang Chun-Sheng Hou Gang Wang Xiao-Si Zhou | 2014 | World Journal of Gastroenterology2014，20，12： | 13 |
| 9 | A novel polyaniline/mesoporous carbon nano-composite electrode for asymmetric supercapacitor显示文摘polyaniline/mesoporous 碳(PANI/CMK-3 )nano 合成的一篇小说与用作支持的 mesoporous 碳(CMK-3 ) 被准备。电气化学的不对称的电容器被分别地把合成的 PANI/CMK-3 和 CMK-3 用作积极、否定的电极成功地设计了。结果证明不对称的电容器的分泌物电容能在 5 mA/cm2 的当前的密度和 1.4 V 的房间电压下面到达 87.4 F/g。不对称的电容器的精力密度直到有 206 W/kg 的力量密度的 23.8 Wh/kg。而且,用这 PANI/CMK-3 的 PANI/CMK-3CMK-3 不对称的电容器 nano 合成能快速被激活并且拥有高 chargedischarge 效率。 | Jian Jun Cai Ling Bin Kong Jing Zhang Yong Chun Luo Long Kang | 2010 | Chinese Chemical Letters2010，21，12： | 11 |
| 10 | Plant food sources and stone tools' function at the site of Shunshanji based on starch grain analysis显示文摘The upper-middle Huai River valley(HRV) is located in the transition zone in the middle of eastern China. Previous studies have shown that the past populations in the upper HRV obtained plant food through gathering and cultivation of both rice and millet during the middle Neolithic. However, for the middle HRV it is not very clear what methods were used by humans to obtain plant food in that time. In this paper, starch grain analysis was carried out on 17 stone tools and 29 cauldron pottery sherds unearthed at Shunshanji(8.5–7.0 kyr BP), which is known as the earliest Neolithic site in the middle HRV excavated so far. Here, ancient starches from Coix lacryma-jobi, Triticeae, Oryza sativa, Trichosanthes kirilowii and one unidentified specie were recovered. This study contributes to the limited knowledge of food strategies as observed in the middle HRV. It demonstrates that both gathering and cultivation of rice took place during the middle-Neolithic. Among the identified species, Coix lacryma-jobi appears to have been the main plant food at Shunshanji. Moreover, it is clear that Oryza sativa was not consumed as much as other plant species according to the occurrence frequency of different starch grains. Starch grains were also found on the used surfaces of grinding stone implements as well as pestles, which means that these stone tools were used for food processing. In addition, axes from Shunshanji may also have been used for food processing as well as wood working because starches were also found on the edge of axes. Information about subsistence strategies and tool use at Shunshanji will also be helpful to understanding the utilization of plants and agricultural development in the middle HRV during the early-middle Neolithic period. | YANG YuZhang LI WeiYa YAO Ling CHENG ZhiJie LUO WuHong ZHANG JuZhong LIN LiuGen GAN HuiYuan YAN Long | 2016 | Science China Earth Sciences2016，59，8： | 9 |
| 11 | Comparison of sentinel lymph node detection performances using blue dye in conjunction with indocyanine green or radioisotope in breast cancer patients: a prospective singlecenter randomized study显示文摘Objective:This randomized study aimed to compare the clinical efficacy between the novel dual tracer composed of indocyanine green(ICG)and blue dye(BD)and the conventional dual tracer composed of radioisotope and BD for sentinel lymph node(SLN)mapping in patients with breast cancer.Methods:This study enrolled 471 clinically lymph node-negative patients with primary breast cancer.All patients underwent mastectomy,and those undergoing sentinel lymph node biopsy(SLNB)were randomized to receive blue dye plus radioisotope(RB group)or BD plus ICG(IB group).The detection performances on SLN identification rate,positive SLN counts,detection sensitivity,and false-negative rate were compared between the two groups.Results:In the IB group,97%(194/200)of the patients who underwent the ICG and BD dual tracer injection showed fluorescentpositive lymphatic vessels within 2–5 min.The identification rate of SLNs was comparable between the IB group(99.0%,198/200)and the RB group(99.6%,270/271)(P=0.79).No significant differences were observed in the identification rate of metastatic SLNs(22.5%vs.22.9%,P>0.05,RB group vs.IB group,the same below),positive SLN counts(3.72±2.28 vs.3.91±2.13,P>0.05),positive metastatic SLN counts(0.38±0.84 vs.0.34±0.78,P>0.05),SLNB detection sensitivity(94.4%vs.92.5%,P>0.05),or false-negative rate(5.6%vs.7.5%,P>0.05)between the two groups.Conclusions:ICG can be used as a promising alternative tracer for radioisotope in SLN mapping,and when it is combined with BD in lymphangiography,it offers comparable detection sensitivity compared to the conventional lymphatic mapping strategies that are widely used in clinical practice. | Long Yuan Xiaowei Qi Yi Zhang Xinhua Yang Fan Zhang Linjun Fan Li Chen Kongyong Zhang Ling Zhong Yanling Li Sijie Gan Wenying Fu Jun Jiang | 2018 | Cancer Biology & Medicine2018，15，4： | 9 |
| 12 | Corrosion and biocompatibility improvement of magnesium-based alloys as bone implant materials:a review显示文摘Magnesium(Mg)or its alloys are widely tested as potential orthopedic implants,particularly as biodegradable alloys for fracture fixation due to their mechanical properties are close to those of bone.Currently,available Mg or its alloys are confronted with challenges in passing regulatory biosafety tests prior to clinical trials due to its fast degradation and associated degradation products.The degradation of Mg is accompanied by the release of Mg ions,the rise of pH and osmolality in surrounding environments.According to the standard of ISO 10993 Part 13,the pH value shall be appropriate to the site of intended use maintaining in an appropriate range.Approaches to overcome these challenges include the selection of adequate alloying elements,proper surface treatment techniques and control of the degradation rate of Mg or its alloys developed as orthopedic implants.To date,Mg or its alloy-based bone implants have not yet been widely used in clinical applications as medical implants.This review critically summarized published methods to improve the corrosion resistance of Mg and its alloys.The current progress on in vitro cytotoxicity and in vivo biocompatibility properties of these metals was also reviewed.This review aimed to provide a reference for further research and development(R&D)of biodegradable Mg and its alloys with regard to the evaluation of their corrosion process and biocompatibility and facilitation of their translation to clinical applications. | Long Li Ming Zhang Ye Li Jie Zhao Ling Qin Yuxiao Lai | 2017 | Regenerative Biomaterials2017，4，2： | 9 |
| 13 | Carbon dioxide capture using polyethylenimine-loaded mesoporous carbons显示文摘A high efficiency sorbent for CO2 capture was developed by loading polyethylenimine (PEI) on mesoporous carbons which possessed well-developed mesoporous structures and large pore volume. The physicochemical properties of the sorbent were characterized by N2 adsorption/desorption, scanning electron microscopy (SEM), thermal gravimetric analysis (TG) and Fourier transform infrared spectroscopy (FT-IR) techniques followed by testing for CO2 capture. Factors that affected the sorption capacity of the sorbent were studied. The sorbent exhibited extraordinary capture capacity with CO2 concentration ranging from 5% to 80%. The optimal PEI loading was determined to be 65 wt.% with a CO2 sorption capacity of 4.82 mmol-CO2 /g-sorbent in 15% CO2 /N2 at 75°C, owing to low mass-transfer resistance and a high utilization ratio of the amine compound (63%). Moisture had a promoting effect on the sorption separation of CO2 . In addition, the developed sorbent could be regenerated easily at 100°C, and it exhibited excellent regenerability and stability. These results indicate that this PEI-loaded mesoporous carbon sorbent should have a good potential for CO2 capture in the future. | Jitong Wang Huichao Chen Huanhuan Zhou Xiaojun Liu Wenming Qiao Donghui Long Licheng Ling | 2013 | Journal of Environmental Sciences2013，25，1： | 9 |
| 14 | Coral reef-like polyanaline nanotubes prepared by a reactive template of manganese oxide for supercapacitor electrode显示文摘由 nanopaticles 组成的珊瑚像礁石的 PANI nanotubes 被锰氧化物的一个反应模板成功地综合。结构被使用 SEM, TEM,和英尺红外描绘,并且这些 nanotubes 的 supercapacitive 行为与周期的 voltammetry (CV ) 被调查,并且 chargedischarge 分别地测试。533 F/g 的一个最大的特定的电容能在 1 mol/L 被完成有 0.2 ~ 0.8 V 的潜在的范围的水的 H2SO4 (对浸透的甘汞电极) 在为 PANI 电极的一种一半房间安装配置,为电气化学的电容器在电极材料建议它的潜在的申请。 | Ling Ren Wang Fen Ran Yong Tao Tan Lei Zhao Ling Bin Kong Long Kang | 2011 | Chinese Chemical Letters2011，22，8： | 8 |
| 15 | Vertically standing PtSe_2 film: a saturable absorber for a passively mode-locked Nd:LuVO_4 laser显示文摘The novel vertically standing Pt Se2 film on transparent quartz was prepared by selenization of platinum film deposited by the magnetron sputtering method, and an Nd:Lu VO4 passively mode-locked solid-state laser was realized by using the fabricated Pt Se2 film as a saturable absorber. The X-ray diffraction pattern and Raman spectrum of the film indicate its good crystallinity with a layered structure. The thickness of Pt Se2 film is measured to be 24 nm according to the cross-section height profile of the atomic force microscope image. Highresolution transmission electron microscopy images clearly demonstrate its vertically standing structure with an interlayer distance of 0.54 nm along the c-axis direction. The modulation depth(ΔT) and saturation fluence(Φs)of Pt Se2 film are measured to be 12.6% and 17.1 μJ∕cm2, respectively. The obtained mode-locked laser spectrum has a central wavelength of 1066.573 nm, with a 3 d B bandwidth of 0.106 nm. The transform limited pulse width of the mode-locked laser was calculated to be 15.8 ps. A maximum average output power of 180 m W with a working repetition rate of 61.3 MHz is obtained. To the best of our knowledge, this is the first report of the generation of ultrafast mode-locked laser pulses by using layered Pt Se2 as a saturable absorber. | LILI TAO XIAOWEN HUANG JUNSHAN HE YAJUN LOU LONGHUI ZENG YONGHUI LI HUI LONG JINGBO LI LING ZHANG YUEN HONG TSANG | 2018 | Photonics Research2018，6，7： | 8 |
| 16 | Syndrome differentiation in traditional Chinese medicine and E-cadherin/ICAM-1 gene protein expression in gastric carcinoma显示文摘AIM:To explore the syndrome differentiation in traditional Chinese medicine (TCM) and gene protein expression in gastric carcinoma. METHODS:Preoperative data of gastric cancer cases were collected from the General Surgery Department and classified according to the criteria for syndrome differentiation in TCM. E-cadherin (E-cad) and ICAM-1 gene protein expressions were detected in postoperative specimens from these cases by the immunohistochemical EnVision two-step method. RESULTS:The E-cad positive expression rate was 90% in 100 cases of gastric carcinoma. The difference in E-cad expression was significant between the different syndrome differentiation types in TCM (P < 0.01). Further group-group comparison showed that there was a significant difference in E-cad expression between the stagnation of phlegm-damp type and the deficiency in both qi and blood and the deficiency-cold of stomach and spleen types,where E-cad expression was high. There was no significant difference between the internal obstruction of stagnant toxin type and the in-coordination between liver and stomach type,where E-cad expression was relatively low. The ICAM-1 positive expression rate was 58%,and there was no statistically significant difference between the two groups (χ2= 8.999,P > 0.05). CONCLUSION:E-cad expression is relatively low in the internal obstruction of stagnant toxin type and the in-coordination between liver and stomach type,where tumor development and metastasis may be associated with low E-cad expression,or with low homogeneous adhesiveness between tumor cells. | Da-Zhi Sun Ling Xu Pin-Kang Wei Long Liu Jin He | 2007 | World Journal of Gastroenterology2007，13，32： | 8 |
| 17 | Detection of serum IgM and IgG for COVID-19 diagnosis显示文摘Dear Editor,Infection with the novel coronavirus(SARS-CoV-2,which is the virus responsible for the coronavirus disease 2019(COVID-19))was first reported in Wuhan,China on December 31,2019.The outbreak of COVID-19 remains ongoing and was linked to more than 80,000 infected patients and more than 3,000 deaths in China as of March 7,2020(Holshue et al.,2020). | Ling Zhong Junlan Chuan Bo Gong Ping Shuai Yu Zhou Yi Zhang Zhilin Jiang Dingding Zhang Xiaoqi Liu Shi Ma Yi Huang He Lin Qingwei Wang Lulin Huang Dan Jiang Fang Hao Juan Tang Chunqi Zheng Hua Yu Zhibin Wang Qi Jiang Tao Zeng Mei Luo Fanwei Zeng Fanxin Zeng Jianghai Liu Junxi Tian Yu Xu Tengxiang Long Kaiju Xu Xingxiang Yang Yuping Liu Yi Shi Li Jiang Zhenglin Yang | 2020 | Science China(Life Sciences)2020，63，5： | 8 |
| 18 | Genetic Analysis of Two Weak Dormancy Mutants Derived from Strong Seed Dormancy Wild Type Rice N22 (Oryza sativa)显示文摘Two weak dormancy mutants,designated Q4359 and Q4646,were obtained from the rice cultivar N22 after treatment with 400 Gy 60Co gamma-radiation.Compared to the N22 cultivar,the dormancy of the mutant seeds was more readily broken when exposed to a period of room temperature storage.The mutants also showed a reduced level of sensitivity to abscisic acid compared to the N22 cultivar,although Q4359 was more insensitive than Q4646.A genetic analysis indicated that in both mutants,the reduced dormancy trait was caused by a single recessive allele of a nuclear gene,but that the mutated locus was different in each case.The results of quantitative trait locus(QTL)mapping,based on the F2 population from Q4359 x Nanjing35,suggested that Q4359 lacks the QTL qSdn-1 and carries a novel allele at QTL qSdn-9, while a similar analysis of the Q4646 x Nanjing35 F2 population suggested that Q4646 lacks QTL qSdn-5, both qSdn-1 and qSdn-5 are major effect seed dormancy QTL in N22.Therefore,these two mutants were helpful to understand the mechanism of seed dormancy in N22. | Bingyue Lu KunXie Chunyan Yang Long Zhang Tao Wu Xi Liu Ling Jiang Jianmin Wan | 2011 | Journal of Integrative Plant Biology2011，53，5： | 7 |
| 19 | Oddi sphincter preserved cholangioplasty with hepaticosubcutaneous stoma for hepatolithiasis显示文摘AIM: To evaluate the long-term outcomes of Oddi sphincter preserved cholangioplasty with hepaticosubcutaneous stoma(OSPCHS) and risk factors for recurrence in hepatolithiasis.METHODS: From March 1993 to December 2012, 202 consecutive patients with hepatolithiasis underwent OSPCHS at our department. The Oddi sphincter preserved procedure consisted of common hepatic duct exploration, stone extraction, hilar bile duct plasty, establishment of subcutaneous stoma to the bile duct. Patients with recurrent stones can undergo stone extraction and/or biliary drainage via the subcutaneous stoma which can be incised under local anesthesia. The long-term results were reviewed. Cox regression model was employed to analyze the risk factors for stone recurrence.RESULTS: Ninety-seven(48.0%) OSPCHS patients underwent hepatic resection concomitantly. The rate of surgical complications was 10.4%. There was no perioperative death. The immediate stone clearance rate was 72.8%. Postoperative cholangioscopic lithotomy raised the clearance rate to 97.0%. With a median follow-up period of 78.5 mo(range: 2-233 mo), 24.8% of patients had recurrent stones, 2.5% had late development of cholangiocarcinoma, and the mortality rate was 5.4%. Removal of recurrent stones and/or drainage of inflammatory bile via subcutaneous stoma were conducted in 44(21.8%) patients. The clearance rate of recurrent stones was 84.0% after subsequent choledochoscopic lithotripsy via subcutaneous stoma.Cox regression analysis showed that residual stone was an independent prognostic factor for stone recurrence.CONCLUSION: In selected patients with hepatolithiasis, OSPCHS achieves excellent long-term outcomes, and residual stone is an independent prognostic factor for stone recurrence. | Yu-Gui Lian Wei-Tao Zhang Zhi Xu Xiao-Feng Ling Li-Xin Wang Chun-Sheng Hou Gang Wang Long Cui Xiao-Si Zhou | 2015 | World Journal of Gastroenterology2015，21，45： | 6 |
| 20 | Poly(ADP-ribosyl)ation of Apoptosis Antagonizing Transcription Factor Involved in Hydroquinone-Induced DNA Damage Response显示文摘The molecular mechanism of DNA damage induced by hydroquinone(HQ)remains unclear.Poly(ADP-ribose)polymerase-1(PARP-1)usually works as a DNA damage sensor,and hence,it is possible that PARP-1 is involved in the DNA damage response induced by HQ.In TK6 cells treated with HQ,PARP activity as well as the expression of apoptosis antagonizing | ling xiao xuan liu jia xian yun lin du yu jun chen shao qian chen jia long tang huan wen liu lin hua | 2016 | Biomedical and Environmental Sciences2016，29，1： | 6 |
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