|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Comparison of survival outcomes between transthoracic and transabdominal surgical approaches in patients with Siewert-Ⅱ/Ⅲesophagogastric junction adenocarcinoma:a single-institution retrospective cohort study显示文摘Objective: To compare the survival outcomes of transabdominal(TA) and transthoracic(TT) surgical approaches in patients with Siewert-Ⅱ/Ⅲ esophagogastric junction adenocarcinoma.Methods: This retrospective study was conducted in patients with Siewert-Ⅱ/Ⅲ esophagogastric junction adenocarcinoma who underwent either TT or TA operations in the West China Hospital between January 2006 and December 2009.Results: A total of 308 patients(109 in the TT and 199 in the TA groups) were included in this study with a follow-up rate of 87.3%. The median(P25, P75) number of harvested perigastric lymph nodes was 8(5, 10) in the TT group and 23(16, 34) in the TA group(P<0.001), and the number of positive perigastric lymph nodes was 2(0, 5) in the TT group and 3(1, 8) in the TA group(P<0.004). The 5-year overall survival(OS) rate was 36% in the TT group and 51% in the TA group(P=0.005). Subgroup analysis by Siewert classification showed that 5-year OS rates for patients with Siewert Ⅱ tumors were 38% and 48% in TT and TA groups, respectively(P=0.134), whereas the 5-year OS rate for patients with Siewert Ⅲ tumors was significantly lower in the TT group than that in the TA group(33% vs. 53%; P=0.010). Multivariate analysis indicated that N2 and N3 stages, R1/R2 resection and a TT surgical approach were prognostic factors for poor OS.Conclusions: Improved perigastric lymph node dissection may be the main reason for better survival outcomes observed with a TA gastrectomy approach than with TT gastrectomy for Siewert Ⅲ tumor patients. | Weihan Zhang Xinzu Chen Kai Liu Kun Yang Xiaolong Chen Ying Zhao Yongfan Zhao Jiaping Chen Longqi Chen Jiankun Hu | 2016 | Chinese Journal of Cancer Research2016，28，4： | 10 |
| 2 | Identification of HSC/MPP expansion units in fetal liver by single-cell spatiotemporal transcriptomics显示文摘Limited knowledge of cellular and molecular mechanisms underlying hematopoietic stem cell and multipotent progenitor(HSC/MPP)expansion within their native niche has impeded the application of stem cell-based therapies for hematological malignancies.Here,we constructed a spatiotemporal transcriptome map of mouse fetal liver(FL)as a platform for hypothesis generation and subsequent experimental validation of novel regulatory mechanisms.Single-cell transcriptomics revealed three transcriptionally heterogeneous HSC/MPP subsets,among which a CD93-enriched subset exhibited enhanced stem cell properties.Moreover,by employing integrative analysis of single-cell and spatial transcriptomics,we identified novel HSC/MPP‘pocket-like’units(HSC PLUS),composed of niche cells(hepatoblasts,stromal cells,endothelial cells,and macrophages)and enriched with growth factors.Unexpectedly,macrophages showed an 11-fold enrichment in the HSC PLUS.Functionally,macrophage-HSC/MPP co-culture assay and candidate molecule testing,respectively,validated the supportive role of macrophages and growth factors(MDK,PTN,and IGFBP5)in HSC/MPP expansion.Finally,cross-species analysis and functional validation showed conserved cell-cell interactions and expansion mechanisms but divergent transcriptome signatures between mouse and human FL HSCs/MPPs.Taken together,these results provide an essential resource for understanding HSC/MPP development in FL,and novel insight into functional HSC/MPP expansion ex vivo. | Suwei Gao Qiang Shi Yifan Zhang Guixian Liang Zhixin Kang Baofeng Huang Dongyuan Ma Lu Wang Jianwei Jiao Xiangdong Fang Cheng-Ran Xu Longqi Liu Xun Xu Berthold Gottgens Cheng Li Feng Liu | 2022 | Cell Research2022，32，1： | 4 |
| 3 | Dynamic cell transition and immune response landscapes of axolotl limb regeneration revealed by single-cell analysis显示文摘Dear Editor,The axolotl,Ambystoma mexicanum,has extraordinary capability to fully recover multiple tissues after lost,whereas such capability has disappeared in mammals.Thus,deci-phering detailed mechanisms underlying axolotl regenera-tion could provide valuable lessons for regenerative medicine.However,many questions,such as the origin of essential progenitor cells and key responses of individual types of cells for regeneration remain elusive(Haas and Whited,2017).Newly developed single-cell RNA sequenc-ing(scRNA-seq)method enables researchers to observe cellular and molecular dynamics in axolotl regeneration at the single-cell resolution(Gerber et al.,2018;Leigh et al.,2018),but the reported transcriptome landscapes are only for certain cell types or in certain regenerative stages.A complete overview of the regeneration process for all cell types is still lacking. | Hanbo Li Xiaoyu Wei Li Zhou Weiqi Zhang Chen Wang Yang Guo Denghui Li Jjianyang Chen Tianbin Liu Yingying Zhang Shuai Ma Congyan Wang Fujian Tan Jiangshan Xu Yang Liu Yue Yuan Liang Chen Qiaoran Wang Jing Qu Yue Shen Shanshan Liu Guangyi Fan Longqi Liu Xin Liu Yong Hou Guang-Hui Liu Ying Gu Xun Xu | 2021 | Protein & Cell2021，12，1： | 3 |
| 4 | Hierarchical sulfur and nitrogen co-doped carbon nanocages as efficient bifunctional oxygen electrocatalysts for rechargeable Zn-air battery显示文摘Exploring inexpensive and efficient bifunctional electrocatalysts for oxygen reduction reaction(ORR) and oxygen evolution reaction(OER) is critical for rechargeable metal-air batteries. Herein, we report a new 3D hierarchical sulfur and nitrogen co-doped carbon nanocages(hSNCNC) as a promising bifunctional oxygen electrocatalyst by an in-situ MgO template method with pyridine and thiophene as the mixed precursor. The as-prepared h SNCNC exhibits a positive half-wave potential of 0.792 V(vs. reversible hydrogen electrode, RHE) for ORR, and a low operating potential of 1.640 V at a 10 mA cm-2 current density for OER. The reversible oxygen electrode index is 0.847 V, far superior to commercial Pt/C and IrO2,which reaches the top level of the reported bifunctional catalysts. Consequently, the hSNCNC as air cathodes in an assembled Zn-air battery features low charge/discharge overpotential and long lifetime. The remarkable properties arises from the introduced multiple heteroatom dopants and stable 3D hierarchical structure with multi-scale pores, which provides the abundant uniform high-active S and N species and efficient charge transfer as well as mass transportation. These results demonstrate the potential strategy in developing suitable carbon-based bi-/multi-functional catalysts to enable the next generation of the rechargeable metal-air batteries. | Hao Fan Yu Wang Fujie Gao Longqi Yang Meng Liu Xiao Du Peng Wang Lijun Yang Qiang Wu Xizhang Wang Zheng Hu | 2019 | Journal of Energy Chemistry2019，28，7： | 3 |
| 5 | Preparation of Au nanoparticles modified TiO_2 nanotube array sensor and its application as chemical oxygen demand sensor显示文摘Au nanoparticles(AuNPs) were electrodeposited at the highly ordered anatase TiO_2 nanotube array(TiO_2 NA) electrode under sonicating, and the AuNP-TiO_2 NA sensor was characterized by scanning electron microscope(SEM), X-ray photoelectron spectroscopy(XPS), X-ray diffraction(XRD). The photoelectrochemical experiments indicate the AuNP-TiO_2 NA sensor has lower photoelectro-resistance,higher photoelectrocatalytical activity and stability than that of pure TiO_2 NA sensor under the same conditions. The as-prepared sensor can be used for the determination of chemical oxygen demand(COD)in real samples, and the obtained results are comparable well with those of by standard K_2Cr_2O_7 method.The method proposed is simple, fast, cost effective, and environmentally friendly. | Longqi Liang Jiao Yin Jinpeng Bao Linchuan Cong Weimin Huang Haibo Lin Zhan Shi | 2019 | Chinese Chemical Letters2019，30，1： | 2 |
| 6 | Design and Implementation of a Communication Network and Operating System for an Adaptive Integrated Hybrid AC/DC Microgrid Module显示文摘This paper proposes an adaptive integrated hybrid AC/DC microgrid module to accommodate a wide range of distributed renewable energy resources(DRERs),distributed energy storage devices(DESDs)and distributed demand resources(DDRs)into the existing distribution systems.This microgrid module is designed to be portable,scalable,easy to deploy,and simple to operate.The modeling of the proposed microgrid module,based on the IEC 61850 standard,is presented.A novel logical node is introduced,which describes functionalities of the bidirectional interlinking converter(BIC)interfacing AC sub-grid and DC sub-grid in a better way.To achieve the target of plug-and-play functionalities,specific microgrid module communication network(MMCN)and microgrid module operating systems(MMOS)are designed and implemented in the hardware prototype built in the laboratory.Experimental results obtained from the lab prototype clearly validate the effectiveness of the proposed design of the microgrid module,communication network and operating system. | Xuewei Pan Longqi Zhang Jianfang Xiao Akshay K.Rathore Peng Wang | 2018 | CSEE Journal of Power and Energy Systems2018，4，1： | 2 |
| 7 | An invasive zone in human liver cancer identified by Stereo-seq promotes hepatocyte–tumor cell crosstalk,local immunosuppression and tumor progression显示文摘Dissecting and understanding the cancer ecosystem,especially that around the tumor margins,which have strong implications for tumor cell infiltration and invasion,are essential for exploring the mechanisms of tumor metastasis and developing effective new treatments.Using a novel tumor border scanning and digitization model enabled by nanoscale resolution-SpaTial Enhanced REsolution Omics-sequencing(Stereo-seq),we identified a 500µm-wide zone centered around the tumor border in patients with liver cancer,referred to as“the invasive zone”.We detected strong immunosuppression,metabolic reprogramming,and severely damaged hepatocytes in this zone.We also identified a subpopulation of damaged hepatocytes with increased expression of serum amyloid A1 and A2(referred to collectively as SAAs)located close to the border on the paratumor side.Overexpression of CXCL6 in adjacent malignant cells could induce activation of the JAK-STAT3 pathway in nearby hepatocytes,which subsequently caused SAAs’overexpression in these hepatocytes.Furthermore,overexpression and secretion of SAAs by hepatocytes in the invasive zone could lead to the recruitment of macrophages and M2 polarization,further promoting local immunosuppression,potentially resulting in tumor progression.Clinical association analysis in additional five independent cohorts of patients with primary and secondary liver cancer(n=423)showed that patients with overexpression of SAAs in the invasive zone had a worse prognosis.Further in vivo experiments using mouse liver tumor models in situ confirmed that the knockdown of genes encoding SAAs in hepatocytes decreased macrophage accumulation around the tumor border and delayed tumor growth.The identification and characterization of a novel invasive zone in human cancer patients not only add an important layer of understanding regarding the mechanisms of tumor invasion and metastasis,but may also pave the way for developing novel therapeutic strategies for advanced liver cancer and other solid tumors. | Liang Wu Jiayan Yan Yinqi Bai Feiyu Chen Xuanxuan Zou Jiangshan Xu Ao Huang Liangzhen Hou Yu Zhong Zehua Jing Qichao Yu Xiaorui Zhou Zhifeng Jiang Chunqing Wang Mengnan Cheng Yuan Ji Yingyong Hou Rongkui Luo Qinqin Li Liang Wu Jianwen Cheng Pengxiang Wang Dezhen Guo Waidong Huang Junjie Lei Shang Liu Yizhen Yan Yiling Chen Sha Liao Yuxiang Li Haixiang Sun Na Yao Xiangyu Zhang Shiyu Zhang Xi Chen Yang Yu Yao Li Fengming Liu Zheng Wang Shaolai Zhou Huanming Yang Shuang Yang Xun Xu Longqi Liu Qiang Gao Zhaoyou Tang Xiangdong Wang Jian Wang Jia Fan Shiping Liu Xinrong Yang Ao Chen Jian Zhou | 2023 | Cell Research2023，33，8： | 1 |
| 8 | Anomaly detection based on efficient Euclidean projection显示文摘 | YANG Longqi HU Guyu LI Dong | 2015 | Security and Communication Networks2015，8，17： | 1 |
| 9 | Elastic dflections of Simply Supported Steel 1 -Beams with a Web Opening 显示文摘 | Donghua Zhou Longqi Li Jtirgen Schnell etal | 2012 | Pro- cedia Engineering2012，31，： | 1 |
| 10 | Nitrogen‐Doped Porous Carbon Nanofiber Webs as Anodes for Lithium Ion Batteries with a Superhigh Capacity and Rate Capability显示文摘 | LongQie Wei‐MinChen Zhao‐HuiWang Qing‐GuoShao XiangLi Li‐XiaYuan Xian‐LuoHu Wu‐XingZhang Yun‐HuiHuang | 2012 | Adv Mater2012，，15： | 1 |
| 11 | Extraction of mode shapes of beam-like structures from the dynamic response of a moving mass显示文摘This paper proposes an approach to extract the mode shapes of beam-like structures from the dynamic response of a moving mass. When a mass passes through a beam containing several artificially installed humps, its vertical acceleration can be recorded. After applying fast Fourier transformation to the dynamic response, one can extract the mode shapes of the beam. The surface roughness was neglected compared to the humps and its adverse effect on the extraction was reduced. The passing mass performs as both “exciter” and “massage receiver”;therefore, this method requires only one single accelerometer, making it more convenient and time saving in practice. Moreover, to estimate the possible error in extracting mode shapes, a wavenumber domain filtering technique is used to reconstruct the general profiles of mode shapes. Experimental validation of this approach in laboratory scale was conducted. The experimental results show that the proposed method performs well in extracting lower order mode shapes. It should also be noted that the passing mass can not have a very high velocity (e.g. 80 mm/s), otherwise the mass may jump and separate from the beam, and the proposed method may fail to identify mode shapes. | Yao Zhang Longqi Wang Haisheng Zhao Seng Tjhen Lie | 2019 | Acta Mechanica Sinica2019，35，3： | 1 |
| 12 | Computational Approaches and Challenges in Spatial Transcriptomics显示文摘The development of spatial transcriptomics(ST)technologies has transformed genetic research from a single-cell data level to a two-dimensional spatial coordinate system and facilitated the study of the composition and function of various cell subsets in different environments and organs.The large-scale data generated by these ST technologies,which contain spatial gene expression information,have elicited the need for spatially resolved approaches to meet the requirements of computational and biological data interpretation.These requirements include dealing with the explosive growth of data to determine the cell-level and gene-level expression,correcting the inner batch effect and loss of expression to improve the data quality,conducting efficient interpretation and in-depth knowledge mining both at the single-cell and tissue-wide levels,and conducting multi-omics integration analysis to provide an extensible framework toward the in-depth understanding of biological processes.However,algorithms designed specifically for ST technologies to meet these requirements are still in their infancy.Here,we review computational approaches to these problems in light of corresponding issues and challenges,and present forward-looking insights into algorithm development. | Shuangsang Fang Bichao Chen Yong Zhang Haixi Sun Longqi Liu Shiping Liu Yuxiang Li Xun Xu | 2023 | Genomics, Proteomics & Bioinformatics2023，21，1： | 0 |
| 13 | Fuzzy cluster analysis of water mass in the western Taiwan Strait in spring 2019显示文摘The classification of the springtime water mass has an important influence on the hydrography,regional climate change and fishery in the Taiwan Strait.Based on 58 stations of CTD profiling data collected in the western and southwestern Taiwan Strait during the spring cruise of 2019,we analyze the spatial distributions of temperature(T)and salinity(S)in the investigation area.Then by using the fuzzy cluster method combined with the T-S similarity number,we classify the investigation area into 5 water masses:the Minzhe Coastal Water(MZCW),the Taiwan Strait Mixed Water(TSMW),the South China Sea Surface Water(SCSSW),the South China Sea Subsurface Water(SCSUW)and the Kuroshio Branch Water(KBW).The MZCW appears in the near surface layer along the western coast of Taiwan Strait,showing low-salinity(<32.0)tongues near the Minjiang River Estuary and the Xiamen Bay mouth.The TSMW covers most upper layer of the investigation area.The SCSSW is mainly distributed in the upper layer of the southwestern Taiwan Strait,beneath which is the SCSUW.The KBW is a high temperature(core value of 26.36℃)and high salinity(core value of 34.62)water mass located southeast of the Taiwan Bank and partially in the central Taiwan Strait. | Zhiyuan Hu Jia Zhu Longqi Yang Zhenyu Sun Xin Guo Zhaozhang Chen Linfeng Huang | 2023 | Acta Oceanologica Sinica2023，42，12： | 0 |
| 14 | Sectional characteristics of temperature, salinity and density off the central Zhejiang coast in the spring of 2016显示文摘In this study, the sectional characteristics of temperature, salinity and density off the central Zhejiang coast were analyzed using three sections of observational data in the spring of 2016. The results are as follows:(1) a cold water patch was observed in the middle layer of sections from 10 to 25 m, and a weak upwelling was observed at the upper layer near the central Zhejiang coast;(2) several thermoclines, inverted thermoclines, and haloclines were observed in the survey area;(3) the Taiwan Warm Current Water(TWCW) climbing from the slope towards the survey area affected the thermocline, making it thinner and intensified; however, the TWCW was not strong enough to break through the thermocline to reach the sea surface. | Longqi Yang Zhaozhang Chen Zhenyu Sun Jianyu Hu | 2019 | Acta Oceanologica Sinica2019，38，4： | 0 |
| 15 | Influence of water and rock particle contents on the shear behaviour of a SRM显示文摘The contents of both water and rock particles are important factors affecting the mechanical strength of a soil–rock mixture(SRM)filled subgrade in the western mountainous area of China.Therefore,the purpose of this paper is to study the mechanisms of reconstituted landslide deposit samples with different water and rock particle contents by analysing the characteristics of shear strength,volumetric strain and‘jumping’phenomenon via large-scale direct shear tests.The results show that the influence of water content on shear strength is greater than the influence of rock particle content under a lower normal stress,and the results are reversed in the case of a higher normal stress.The effect of water content on the equivalent cohesion is bigger,especially for the sample with a high rock particle content.The friction angle of the specimen with same water content increases with the increasing rock particle content,but when the number of rock particles increases to a certain extent,there is a little effect on the friction angle.However,the friction angle decreases with increasing water content at the same rock particle content.Specimens with the same rock particle content change from dilation to compression with increasing water content.Finally,the continuous stage of the‘intense jumping’at different water content has been analysed.The‘jumping’phenomenon of samples with low water and rock particle content will first strengthen and then weaken the samples with increasing normal stress. | Longqi Liu Xuesong Mao Yajun Xiao Tiequan Wang Menglan Nie | 2020 | Transportation Safety and Environment2020，2，1： | 0 |
| 16 | Downregulated miR-451a as a feature of the plasma cfRNA landscape reveals regulatory networks of IL-6/IL-6R-associated cytokine storms in COVID-19 patients显示文摘Rapidly spreading coronavirus disease 2019(COVID-19)is currently affecting the world.Specifically,cytokine storms are a key feature in a substantial num ber of COVID-19 patients,1 and studies from our group and others suggest that the IL-6/IL-6R cascade plays a dom inant role in symptom-correlated cytokine storms. | Penghui Yang Yingze Zhao Jie Li Chuanyu Liu Linnan Zhu Jie Zhang Yeya Yu Wen-Jing Wang Guanglin Lei Jin Yan Fang Sun Chengrong Bian Fanping Meng Zhe Xu Changqing Bai Beiwei Ye Yuanyuan Guo Liumei Shu Xiaoju Yuan Ning Zhang Yuhai Bi Yi Shi Guizhen Wu Shaogeng Zhang George F.Gao Longqi Liu William J.Liu Hai-Xi Sun | 2021 | Cellular & Molecular Immunology2021，18，4： | 0 |
| 17 | CDCP:a visualization and analyzing platform for single-cell datasets显示文摘Recently,the rapid advances of single-cell sequencing technologies,including sequencing of single-cell genomics,transcriptomes,epigenetics,and spatial transcriptomes,have empowered researchers to scrutinize cellular heterogeneity,gene expression,epigenetic modifications. | Yuejiao Li Tao Yang Tingting Lai Lijin You Fan Yang Jiaying Qiu Lina Wang Wensi Du Cong Hua Zhicheng Xu Jia Cai Zhiyong Li Yiqun Liu Ling Li Minwen Zhang Jing Chen Lei Zhang Dongsheng Chen Weiwen Wang Shiping Liu Liang Wu Wenjun Zeng Bo Wang Xiaofeng Wei Longqi Liu Fengzhen Chen | 2022 | Journal of Genetics and Genomics2022，49，7： | 0 |
| 18 | Spatial transcriptome unveils a discontinuous inflammatory pattern in proficient mismatch repair colorectal adenocarcinoma显示文摘The preexistence of immune cells in the tumor microenvironment substantiates the efficacy of immunotherapy in cancer patients.Although the complex intratumoral immune heterogeneity has been extensively studied in single cell resolution,hi-res spatial investigations are limited.In this study,we performed a spatial transcriptome analysis of 4 colorectal adenocarcinoma specimens and 2 paired distant normal specimens to identify the molecular pattern involved in a discontinuous inflammatory response in pathologically annotated cancer regions.Based on the location of spatially varied gene expression,we unmasked the spatially-varied immune ecosystem and identified the locoregional“warmed-up”immune response in predefined“cold”tumor with substantial infiltration of immune components.This“warmed-up”immune profile was found to be associated with the in-situ copy number variance and the tissue remodeling process.Further,“warmed-up”signature genes indicated improved overall survival in CRC patients obtained from TCGA database. | Rongxin Zhang Yu Feng Wenjuan Ma Yanying Guo Mei Luo Young Li Yupeng Zang Xuan Dong Shixun Lu Qiang Guo Qumiao Xu Huanyi Chen Yijian Li Longqi Liu Ao Chen Gong Chen Xun Xu | 2023 | Fundamental Research2023，3，4： | 0 |
| 19 | Comparison for ecological economic performance of Chinese sea perch(Lateolabrax Maculatus)under different aquaculture systems显示文摘Chinese sea perch(Lateolabrax Maculatus)is one of the main marine fish culture species in China,its green development has received increasing attention and its ecological economic study is rare.Based on field survey,this paper takes water pollution tax of China as conversion indicator for aquaculture eutrophication to simulate aquaculture waste fee for further analyzing the ecological impact of Chinese sea perch’s aquaculture.For data analysis,data envelopment analysis model has been used.The comparison for Chinese sea perch’s economic performance and ecological economic performance under its main aquaculture systems has been done.The results show that:1.The simulated waste fee has no significant impact for the comparison.2.Ranking for ecological economic performance’s ecological economic,technical and scale efficiency is as follow:pond farming,offshore cage culture and cage culture.3.Offshore cage culture is the only system presenting positive increase for ecological economic performance,which makes its aquaculture activity more sustainable than other systems.4.The key point of green development is to maximize the ecological economic efficiency of main aquaculture systems.Thus,offshore cage culture is the most sustainable aquaculture system among China’s current marine fish culture systems,and other systems need innovation for achieving the green development of China’s aquaculture. | Zhiyi Zhang Xiu Fang Longqi Sun | 2022 | Aquaculture and Fisheries2022，7，6： | 0 |
| 20 | A Highly Selective and Sensitive Ratiometric Fluorescent Probe for Hypochlorite and Its Application显示文摘 | XUE Longqi FENG Yusha SONG Yan WANG Rui LIU Dahai DU Jianshi YANG Qingbiao LI Yaoxian | 2018 | Chemical Research in Chinese Universities2018，34，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员