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| 1 | A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV) infected pneumonia(standard version)显示文摘In December 2019, a new type viral pneumonia cases occurred in Wuhan, Hubei Province;and then named '2019 novel coronavirus(2019-nCoV)' by the World Health Organization(WHO) on 12 January 2020. For it is a never been experienced respiratory disease before and with infection ability widely and quickly, it attracted the world’s attention but without treatment and control manual. For the request from frontline clinicians and public health professionals of 2019-nCoV infected pneumonia management, an evidence-based guideline urgently needs to be developed. Therefore, we drafted this guideline according to the rapid advice guidelines methodology and general rules of WHO guideline development;we also added the first-hand management data of Zhongnan Hospital of Wuhan University. This guideline includes the guideline methodology, epidemiological characteristics, disease screening and population prevention, diagnosis, treatment and control(including traditional Chinese Medicine), nosocomial infection prevention and control, and disease nursing of the 2019-nCoV. Moreover, we also provide a whole process of a successful treatment case of the severe 2019-nCoV infected pneumonia and experience and lessons of hospital rescue for 2019-nCoV infections. This rapid advice guideline is suitable for the first frontline doctors and nurses, managers of hospitals and healthcare sections, community residents, public health persons, relevant researchers, and all person who are interested in the 2019-nCoV. | Ying-Hui Jin Lin Cai Zhen-Shun Cheng Hong Cheng Tong Deng Yi-Pin Fan Cheng Fang Di Huang Lu-Qi Huang Qiao Huang Yong Han Bo Hu Fen Hu Bing-Hui Li Yi-Rong Li Ke Liang Li-Kai Lin Li-Sha Luo Jing Ma Lin-Lu Ma Zhi-Yong Peng Yun-Bao Pan Zhen-Yu Pan Xue-Qun Ren Hui-Min Sun Ying Wang Yun-Yun Wang Hong Weng Chao-Jie Wei Dong-Fang Wu Jian Xia Yong Xiong Hai-Bo Xu Xiao-Mei Yao Yu-Feng Yuan Tai-Sheng Ye Xiao-Chun Zhang Ying-Wen Zhang Yin-Gao Zhang Hua-Min Zhang Yan Zhao Ming-Juan Zhao Hao Zi Xian-Tao Zeng Yong-Yan Wang Xing-Huan Wang 无 | 2020 | Military Medical Research2020，7，1： | 161 |
| 2 | Paleogene-Neogene stratigraphic realm and sedimentary sequence of the Qinghai-Tibet Plateau and their response to uplift of the plateau显示文摘Based on the data of 1:250000 geological mapping completed by CGS and the previous literature of the Cenozoic strata, 98 remnant basins and 5 stratigraphic realms with 13 stratigraphic subrealms have been recognized on the Qinghai-Tibet Plateau and its adjacent area. Through the research of the types of remnant basins, tectonic setting, stratigraphic sequence and sedimentary characteristics, contact relationship between the strata, the formation time and evolution history of sediments, we divided the uplift process and sedimentary response of the Qinghai-Tibet Plateau into 3 stages and 8 sub-stages, namely, subduction-collision uplift stage (65-34 Ma) with three sub-stages, intercontinental convergence and compressive uplift stage (34-13 Ma) with three sub-stages, and intercontinental isostatic adjustment uplift stage (since 13 Ma) with two sub-stages. | ZHANG KeXin WANG GuoCan JI JunLiang LUO ManSheng KOU XiaoHu WANG YueMing XU YaDong CHEN FenNing CHEN RuiMing SONG BoWen ZHANG JianYu LIANG YinPing | 2010 | Science China Earth Sciences2010，53，9： | 49 |
| 3 | 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘象 5-methylcytosine (5mC ) 和 5-hydroxymethylcytosine (5hmC ) 那样的 DNA 修正是知道在哺乳动物影响全球基因表示的 epigenetic 标记。在人的染色体,与基因表示的靠近的关联和高化学的稳定性给他们的流行,这些 DNA epigenetic 标记能为癌症用作理想的 biomarkers 诊断。利用一种高度敏感、选择的化学标记技术,我们这里报导在传播没有房间的 DNA ( cfDNA )并且在从最近与 colorectal 诊断的 260 个病人的一个队收集的配对的肿瘤和邻近的纸巾的 genomic DNA ( gDNA )的 5hmC 的染色体宽的介绍,胃,胰腺,从 90 个健康个人的肝或甲状腺癌症和正常纸巾。5hmC 主要在与开的染色质和容许的 histone 修正重合的 transcriptionally 活跃的区域被散布。柔韧的联系癌症的 5hmC 签名在 cfDNA 被识别为特定的癌症类型是特征的。传播 cfDNA 的 5hmC 底 biomarkers colorectal 和胃的癌症是高度预兆的并且比常规 biomarkers 优异并且比得上从织物活体检视的 5hmC biomarkers。因此,这新策略能从血样品的分析为癌症的诊断和预后导致有效、最低限度地侵略的方法的发展。 | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2017 | Cell Research2017，27，10： | 30 |
| 4 | The Status and Associated Factors of Successful Aging among Older Adults Residing in Longevity Areas in China显示文摘Objective This study aims to assess the status of successful aging(SA) in longevity areas in China and explore multiple factors associated with SA among the young-old and oldest-old. Methods A total of 2296 elderly people aged 65 and older were interviewed in the longevity areas sub-sample of the Chinese Longitudinal Healthy Longevity Survey(CLHLS) in 2012. Baseline assessments included a researcher-administered questionnaire, physical examination, and laboratory testing. A logistic regression model was used to identify factors associated with SA. Results The prevalence of SA was 38.81% in the CLHLS in 2012. There were significant differences between ages groups, with SA compromising 56.85% among ≥65 years group and 20.31% among ≥100 years group(χtrend2=126.73, P<0.01). The prevalence of SA among females was 33.59%, which was significantly lower than that among males(45.58%)(χ2gender=33.65, P<0.05). In the regression analysis, having anemia(OR=0.744, 95% CI: 0.609-0.910), poor lifestyle(OR=0.697, 95% CI: 0.568-0.854), poor sleep quality(OR=0.558, 95% CI: 0.456-0.682), and central obesity(OR=0.684, 95% CI: 0.556-0.841) were the main factors associated with SA. The promoting SA rate decreased as age increased, and the group of 65-79 years had higher odds than the other age group. Conclusion Preventing central obesity, improving sleep quality and promoting healthy lifestyle may contribute to achieve SA among the elderly. | SHI Wen Hui ZHANG Hong Yan ZHANG Juan LYU Yue Bin Melanie Sereny Brasher YIN Zhao Xue LUO Jie Si HU Dong Sheng FEN Lei SHI Xiao Ming | 2016 | Biomedical and Environmental Sciences2016，29，5： | 10 |
| 5 | Micro RNA profiles and potential regulatory pattern during the early stage of spermatogenesis in mice显示文摘Spermatogenesis is a complicated and poorly understood process that relies on the precise regulation of the self-renewal and differentiation of spermatogonia. In many organisms, micro RNAs(mi RNAs) are involved in multiple developmental processes as critical regulators of transcriptional and post-transcriptional gene silencing. This study investigated the expression pattern of mi RNAs in type B spermatogonia cells(BSc) and primary spermatocytes(PSc) of mice, using a high-throughput small RNA sequencing system. The results revealed that the expression levels of Let-7 family mi RNAs were remarkably high in both cell types. Furthermore, the expression levels of mi R-21, mi R-140-3p, mi R-103, mi R-30 a, mi R-101 b and mi R-99 b were decreased during the transformation from BSc to PSc. These mi RNAs target vital genes that participate in apoptosis, cell proliferation and differentiation, junction assembly and cell cycle regulation. These results highlight the indispensable role of mi RNAs in spermatogenesis. | LUO MengMeng HAO LiLi HU Fen DONG YaNan GOU LiXia ZHANG WenDian WANG Xin ZHAO YuHui JIA MengChun HU SongNian ZHANG XiuJun | 2015 | Science China(Life Sciences)2015，58，5： | 6 |
| 6 | Food Frequency Questionnaire for Chinese Children Aged 12-17 Years: Validity and Reliability显示文摘Objective The primary objective of this study was to examine the validity and reliability of a semi-quantitative food frequency questionnaire(FFQ) among Chinese children aged 12-17 years. Methods A semi-quantitative 72-food item FFQ was developed for children aged 12-17 years. The reliability and validity of this FFQ were evaluated against 24-h dietary recalls(24 h DRs) to measure the consumption of foods and nutrients. We administered two FFQs and three DRs to children(N = 160) over a period of 1 month to evaluate the reliability and validity. Reliability was examined by quartile agreement and intraclass correlation coefficients(ICCs), and validity was examined by quartile agreement, Bland-Altman plots and correlation with DRs. Results For reliability, the ICCs between the two FFQs ranged from 0.21 to 0.76 for foods and nutrients, and the quartile agreement ranged from 70.0% to 95.0% in the same or adjacent quartiles. Spearman’s correlation coefficients of foods and nutrients between the second FFQ and the 24 h DRs ranged from-0.04 to 0.59. The Bland-Altman plots demonstrated good agreement across the range of intakes among nutrients. The quartile agreement ranged from 50.0% to 100.0%, with infrequent misclassification. Conclusion The FFQ assessment of dietary intakes demonstrated acceptable relative validity and high reproducibility for Chinese children aged 12-17 years. | LIU Dan JU La Hong YANG Zhen Yu ZHANG Qian GAO Jian Fen GONG Di Ping GUO Dan Dan LUO Shu Quan ZHAO Wen Hua | 2019 | Biomedical and Environmental Sciences2019，32，7： | 6 |
| 7 | Sedimentary Evolution of the Qinghai-Tibet Plateau in Cenozoic and its Response to the Uplift of the Plateau显示文摘We have studied the evolution of the tectonic lithofacies paleogeography of Paleocene-Eocene, Oligocene, Miocene, and Pliocene of the Qinghai-Tibet Plateau by compiling data regarding the type, tectonic setting, and lithostratigraphic sequence of 98 remnant basins in the plateau area. Our results can be summarized as follows. (1) The Paleocene to Eocene is characterized by uplift and erosion in the Songpan-Garzê and Gangdisê belts, depression (lakes and pluvial plains) in eastern Tarim, Qaidam, Qiangtang, and Hoh Xil, and the Neo-Tethys Sea in the western and southern Qinghai-Tibet Plateau. (2) The Oligocene is characterized by uplift in the Gangdisê-Himalaya and Karakorum regions (marked by the absence of sedimentation), fluvial transport (originating eastward and flowing westward) in the Brahmaputra region (marked by the deposition of Dazhuka conglomerate), uplift and erosion in western Kunlun and Songpan-Garzê, and depression (lakes) in the Tarim, Qaidam, Qiangtang, and Hoh Xil. The Oligocene is further characterized by depressional littoral and neritic basins in southwestern Tarim, with marine facies deposition ceasing at the end of the Oligocene. (3) For the Miocene, a widespread regional unconformity (ca. 23 Ma) in and adjacent to the plateau indicates comprehensive uplift of the plateau. This period is characterized by depressions (lakes) in the Tarim, Qaidam, Xining-Nanzhou, Qiangtang, and Hoh Xil. Lacustrine facies deposition expanded to peak in and adjacent to the plateau ca. 18-13 Ma, and north-south fault basins formed in southern Tibet ca. 13-10 Ma. All of these features indicate that the plateau uplifted to its peak and began to collapse. (4) Uplift and erosion occurred during the Pliocene in most parts of the plateau, except in the Hoh Xil-Qiangtang, Tarim, and Qaidam. The continuous uplift and intensive taphrogeny in the plateau divided the original large basin into small basins, deposition of lacustrine facies decreased considerably, and boulderstone accumulated, indicating a response to the overall uplift of the plateau. Here, we discuss the evolution of tectonic lithofacies paleogeography in Cenozoic and its response to the tectonic uplift of the Qinghai-Tibet Plateau in relation to the above characteristics. We have recognized five major uplift events, which occurred during 58-53 Ma, 45-30 Ma, 25-20 Ma, 13-7 Ma, and since 5 Ma. The results presented here indicate that the paleogeomorphic configurations of the Qinghai-Tibet Plateau turned over during the late Miocene, with high elevations in the east during the pre-Miocene switching to high contours in the west at the end of Miocene. | ZHANG Kexin WANG Guocan XU Yadong LUO Mansheng JI Junliang XIAO Guoqiao WANG An SONG Bowen LIANG Yinpin JIANG Shangsong CAO Kai CHEN Fenning CHEN Ruiming YANG Yongfeng | 2013 | Acta Geologica Sinica(English Edition)2013，87，2： | 6 |
| 8 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 9 | The efficacy and safety of modified FOLFIRINOX as first-line chemotherapy for Chinese patients with metastatic pancreatic cancer显示文摘Background: Oxaliplatin, irinotecan, 5-fluorouracil, and l-leucovorin (FOLFIRINOX) has become one of the first-line treatment options for advanced pancreatic cancer (PC). However, the relatively high rate of grade 3 or 4 adverse events associated with the standard dosage of FOLFIRINOX limits its widespread use in clinical practice. In this study, we were to evaluate the efficacy and safety of a modified FOLFIRINOX regimen as a first-line chemotherapy for Chinese patients with metastatic PC. Methods: Patients with histologically confirmed primary metastatic pancreatic adenocarcinoma with an Eastern Cooperative Oncology Group (ECOG) performance status score of 0-2 were recruited to receive the modified FOLFIRINOX regimen (intravenous infusion of oxaliplatin, 65 mg/m2;irinotecan, 150 mg/m2;l-leucovorin, 200 mg/ m2;and 5-fluorouracil, 2400 mg/m2, repeated every 2 weeks). The treatment was continued for 12 cycles unless the patient had progressive disease (PD), stable disease (SD) with symptom deterioration, unacceptable adverse events, or requested to terminate the treatment prematurely. The primary endpoint was objective response rate (ORR). Results: Sixty-five patients were enrolled from July 2012 to April 2017 in three institutions, and they all received at least one cycle of chemotherapy, with a median of 8 cycles (range 1-12 cycles). No complete response was observed. Twenty-one (32.3%) patients had partial responses, and 27 (41.5%) had SD. The ORR and disease control rate of the study cohort was 32.3% and 73.8%. The estimated median overall survival and progression-free survival were 11.60 (95% confidence interval [CI] 8.76-14.44) and 5.77 (95% CI 5.00-6.54) months. Major grade 3 or 4 adverse events included neutropenia (12.3%) and diarrhea (6.2%). No treatment-related death was observed. Conclusions: Modified FOLFIRINOX was well-tolerated and might be a promising option as first-line therapy for Chinese patients with metastatic PC. | Zhi-Qiang Wang Fei Zhang Ting Deng Le Zhang Fen Feng Feng-Hua Wang Wei Wang De-Shen Wang Hui-Yan Luo Rui-Hua Xu Yi Ba Yu-Hong Li | 2019 | Cancer Communications2019，39，1： | 4 |
| 10 | Interaction of Mouse Pem Protein and Cell Division Cycle 37 Homolog显示文摘老鼠 Pem, homeobox 基因,编码由 210 氨基酸残余组成的蛋白质。学习老鼠 Pem 蛋白质的功能,我们使用了酵母与全身的老鼠 Pem cDNA 屏蔽 7 天的老鼠胚胎的图书馆的二混血儿的系统。52 个殖民地在 1.57 x 10 以后被获得(8 ) 殖民地被营养屏蔽限制和贝它牛乳糖试金。七个个人插入碎片从图书馆被获得,并且他们中的三个被识别哪个之一被证实是细胞分裂周期 37 (Cdc37 ) 由定序的相当或相同的事物基因。在老鼠 Pem 和 Cdc37 相当或相同的事物之间的相互作用然后被谷胱甘肽 S-transferase 下拉试金证实,并且可能的相互作用模型被建议。 | Fen GUO Yue-Qin LI Shi-Qian LI Zhi-Wen LUO Xin ZHANG Dong-Sheng TANG Tian-Hong ZHOU | 2005 | Acta Biochimica et Biophysica Sinica2005，37，11： | 3 |
| 11 | Comparative genomic study of gastric epithelial cells co-cultured with Helicobacter pylori显示文摘AIM:To identify genes potentially involved in Helicobacter pylori(H.pylori)-induced gastric carcinogenesis.METHODS:GES-1 cells were co-cultured with H.pylori strains isolated from patients with gastric carcinoma(GC,n = 10) or chronic gastritis(CG,n = 10) for in vitro proliferation and apoptosis assays to identify the most and least virulent strains.These two strains were cagA-genotyped and used for further in vivo carcinogenic virulence assays by infecting Mongolian gerbils for 52 wk,respectively;a broth free of H.pylori was lavaged as control.Genomic profiles of GES-1 cells cocultured with the most and least virulent strains were determined by microarray analysis.The most differentially expressed genes were further verified using quantitative real-time polymerase chain reaction in GES-1cells infected with the most and least virulent strains,and by immunohistochemistry in H.pylori positive CG,precancerous diseases,and GC biopsy specimens in an independent experiment.RESULTS:GC-derived H.pylori strains induced a potent proliferative effect in GES-1 cells in co-culture,whereas CG-derived strains did not.The most(from a GC patient) and least(from a CG patient) virulent strains were cagA-positive and negative,respectively.At week 52,CG,atrophy,metaplasia,dysplasia,and GC were observed in 90.0%,80.0%,80.0%,90%,and 60.0%,respectively,of the animals lavaged with the most virulent strain.However,only mild CG was observed in 90% of the animals lavaged with the least virulent strain.On microarray analysis,800 differentially expressed genes(49 up-and 751 down-regulated),involving those associated with cell cycle regulation,cell apoptosis,cytoskeleton,immune response,and substance and energy metabolisms,were identified in cells co-cultured with the most virulent strain as compared with those co-cultured with the least virulent strain.The six most differentially expressed genes(with a betweenness centrality of 0.1-0.2) were identified among the significant differential gene profile network,including JUN,KRAS,BRCA1,SMAD2,TRAF1,and HDAC6.Quantitative real-time polymerase chain reaction analyses verified that HDAC6 and TRFA1 mRNA expressions were significantly more up-regulated in GES-1 cells cocultured with the most virulent strain than in those cocultured with the least virulent strain.Immunohistochemistry of gastric mucosal specimens from H.pyloripositive patients with CG,intestinal metaplasia(IM),dysplasia,and GC showed that moderately positive and strongly positive HDAC6 expression was detected in 21.7% of CG patients,30.0% of IM patients,54.5% of dysplasia patients,and 77.8% of GC patients(P < 0.001).The up-regulation of TRAF1 expressions was detected in 34.8%,53.3%,72.7%,and 88.9% specimens of CG,IM,dysplasia,and GC,respectively(P < 0.001).CONCLUSION:The overexpression of HDAC6 and TRAF1 in GES-1 cells co-cultured with the GC-derived strain and in H.pylori-positive dysplasia and GC suggests that HDAC6 and TRAF1 may be involved in H.pyloriinduced gastric carcinogenesis. | Fen Wang Li-Dan Luo Jian-Hua Pan Li-Hua Huang Hong-Wei Lv Qin Guo Can-Xia Xu Shou-Rong Shen | 2012 | World Journal of Gastroenterology2012，18，48： | 3 |
| 12 | A new ellagitannin from Cleidion bracteosum显示文摘A new ellagitannin, named bractin (1), had been isolated from the dried aerial part of Cleidion bracteosum. Its structure was determined based on various of spectral analysis. | Peng Ju Yi Fen Wang Qiong Wang Shi De Luo | 2007 | Chinese Chemical Letters2007，18，3： | 2 |
| 13 | Exposure to bifenthrin disrupts the development of testis in male Sebastiscus marmoratus显示文摘Bifenthrin(BF) is a pyrethroid insecticide that is widely used in agriculture, horticulture, and for residential purposes. However, few studies addressing the reproductive toxicity of BF on fishes are available. The present study was conducted to investigate the effects of BF on testicular development in Sebastiscus marmoratus and to gain insight into its mechanism. After exposure to 1, 10 and 100 ng/L BF for 50 days, there was a reduced number of mature sperm and an abundance of the late stages of spermatocysts in the testes. The levels of 17β-estradiol and testosterone were decreased significantly after BF exposure. The activity of caspase-3 was increased in a dosedependent manner after BF exposure, TUNEL assay indicated that BF exposure resulted in the occurrence of apoptosis in the testes, which might be main reason for the inhibition of spermatogenesis. | LI Jinshou LUO Fen LIU Liyue RUAN Junfeng WANG Nannan | 2017 | Acta Oceanologica Sinica2017，36，2： | 2 |
| 14 | Golden Promise barley(Hordeum vulgare) is a suitable candidate model host for investigation interaction with Heterodera avenae显示文摘Heterodera avenae(cereal cyst nematode, CCN) infects many cereal crops and causes serious yield losses worldwide. Interaction studies investigating H. avenae and its hosts are still in their infancy. In this study, a barley model plant, the Hordeum vulgare cultivar Golden Promise, was investigated for its potential as a candidate model host to study its interaction with H. avenae. CCN-infective juveniles were attracted by the root tips and gathered around the root elongation zones of Golden Promise on 0.7% water agar plates. The juveniles invaded the roots and developed successfully until maturation at 40 days after inoculation in sterile sand soil. The cryotomy and syncytium measurements indicated that the syncytia enlarged gradually throughout the development of the nematodes and caused the corresponding root regions to swell obviously. Quantitative real-time PCR analysis showed that the down-regulation of defence-related barley genes and up-regulation of development-related barley genes contribute to the understanding of compatible interaction between H. avenae and Golden Promise. Barley stripe mosaic virus(BSMV) virus-induced gene silencing(VIGS) can be used in the roots of Golden Promise. In conclusion, the Hordeum vulgare cultivar Golden Promise is a suitable candidate model host for interaction studies with Heterodera avenae. The studies presented above document the first CCN host that not only has published genome context but also be compatible to BSMV VIGS. | LUO Shu-jie KONG Ling-an PENG Huan HUANG Wen-kun CUI Jiang-kuan LIU Jing QIAO Fen JIAN Heng PENG De-liang | 2017 | Journal of Integrative Agriculture2017，16，7： | 2 |
| 15 | 改良FOLFIRINOX方案一线化疗中国转移性胰腺癌患者的疗效与安全性研究显示文摘背景与目的奥沙利铂(oxaliplatin)、伊立替康(irinotecan)、5-氟尿嘧啶(5-fluorouracil)和1-醛氢叶酸(l-leucovorin)联合用药(即FOLFIRINOX方案)已成为晚期胰腺癌(pancreatic cancer,PC)的一线治疗方案之一。然而,与FOLFIRINOX标准剂量相关的3级或4级不良事件的较高发生率限制了该方案在临床上的广泛应用。在本研究中,我们对改良FOLFIRINOX方案一线化疗中国转移性PC患者的疗效和安全性进行了评价。方法将组织学证实为原发转移性胰腺癌,且东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)体能状态评分为0-2的患者纳入本研究。所有患者均接受改良FOLFIRINOX方案治疗(静脉滴注奥沙利铂65 mg/m^2、伊立替康150 mg/m^2、l-醛氢叶酸200 mg/m^2、5-氟尿嘧啶2400 mg/m^2,每2周重复1次)。治疗持续12个周期,除非患者出现疾病进展(progressive disease,PD)、症状恶化的疾病稳定(stable disease,SD)、不可耐受的不良事件或要求提前终止治疗。主要终点为客观缓解率(objective response rate,ORR)。结果2012年7月至2017年4月期间,共有来自3个机构的65例患者被纳入本研究。所有患者均接受了至少1个周期化疗,化疗周期中位数为8个周期(范围:1-12个周期)。本研究中未观察到完全缓解。21(32.3%)例患者为部分缓解,27(41.5%)例表现为SD。总体人群的ORR和疾病控制率(diseasecontrol rate,DCR)分别为32.3%和73.8%。中位总生存期和无进展生存期分别为11.60[95%置信区间(confidence interval,CI):8.76-14.44]个月和5.77(95%CI:5.00-6.54)个月。主要的3级或4级不良事件包括中性粒细胞减少(12.3%)和腹泻(6.2%)。未观察到与治疗相关的死亡。结论改良FOLFIRINOX具有良好的耐受性,可作为中国转移性PC中国患者的一线治疗方案。 | Zhi‑Qiang Wang Fei Zhang Ting Deng Le Zhang Fen Feng Feng‑Hua Wang Wei Wang De‑Shen Wang Hui‑Yan Luo Rui‑Hua Xu Yi Ba Yu‑Hong Li | 2019 | 癌症2019，38，8： | 2 |
| 16 | Inverted U-Shaped Associations between Glycemic Indices and Serum Uric Acid Levels in the General Chinese Population:Findings from the China Cardiometabolic Disease and Cancer Cohort(4C)Study显示文摘Objective The relationship between serum uric acid(SUA)levels and glycemic indices,including plasma glucose(FPG),2-hour postload glucose(2 h-PG),and glycated hemoglobin(HbA1 c),remains inconclusive.We aimed to explore the associations between glycemic indices and SUA levels in the general Chinese population.Methods The current study was a cross-sectional analysis using the first follow-up survey data from The China Cardiometabolic Disease and Cancer Cohort Study.A total of 105,922 community-dwelling adults aged≥40 years underwent the oral glucose tolerance test and uric acid assessment.The nonlinear relationships between glycemic indices and SUA levels were explored using generalized additive models.Results A total of 30,941 men and 62,361 women were eligible for the current analysis.Generalized additive models verified the inverted U-shaped association between glycemic indices and SUA levels,but with different inflection points in men and women.The thresholds for FPG,2 h-PG,and HbA1 c for men and women were 6.5/8.0 mmol/L,11.0/14.0 mmol/L,and 6.1/6.5,respectively(SUA levels increased with increasing glycemic indices before the inflection points and then eventually decreased with further increases in the glycemic indices).Conclusion An inverted U-shaped association was observed between major glycemic indices and uric acid levels in both sexes,while the inflection points were reached earlier in men than in women. | ZHU Yuan Yue ZHENG Rui Zhi WANG Gui Xia CHEN Li SHI Li Xin SU Qing XU Min XU Yu CHEN Yu Hong YU Xue Feng YAN Li WANG Tian Ge ZHAO Zhi Yun QIN Gui Jun WAN Qin CHEN Gang GAO Zheng Nan SHEN Fei Xia LUO Zuo Jie QIN Ying Fen HUO Ya Nan LI Qiang YE Zhen ZHANG Yin Fei LIU Chao WANG You Min WU Sheng Li YANG Tao DENG Hua Cong ZHAO Jia Jun CHEN Lu Lu MU Yi Ming TANG Xu Lei HU Ru Ying WANG Wei Qing NING Guang LI Mian LU Jie Li BI Yu Fang | 2021 | Biomedical and Environmental Sciences2021，34，1： | 2 |
| 17 | Hydrogen- rich gas production by steam gasification of char from biomass fast pyrolysis in a fixed-bed reactor: lnfluenc:e of temperature and steam on hydrogen yield and syngas composition 显示文摘 | FEN( YAN SI-YI LUO ZH1-QUAN HU | 2010 | Bioresource Technology2010，104，14： | 1 |
| 18 | Children(s) and Adults'Conceptualization and Evaluation of Lying and Truth telling显示文摘 | Fen Xu Yang C Luo Gen yue Fu Kang Lee | | 0，，04： | 1 |
| 19 | Cobalt(Ⅱ)coordination polymers as anodes for lithium-ion batteries with enhanced capacity and cycling stability显示文摘Coordination polymer Co-btca(H4 btca = 1,2,4,5-benzenetetracarboxylic acid) was synthesized using a simply hydrothermal method.In particular,the as-prepared Co-btca was applied as an anode material for lithium-ion battery for the first time.Single crystal X-ray diffraction results indicated that the asprepared Co-btca displayed unique layer structure,which was beneficial to transport Li ions and electrons.Also,owing to the porous structure and appropriate specific surface area,Co-btca electrode delivered a reversible capacity of 801.3 m A h/g after 50 cycles at a current density of 200 m A/g.The reversible capacity of 773.9 m A h/g was maintained after 200 cycles at a current density of 500 m A/g,exhibiting enhanced cycle stability.It also showed improved rate performance,making it a promising anode material and a new choice for lithium-ion batteries. | Yumei Luo Lixian Sun Fen Xu Siyue Wei Qingyong Wang Hongliang Peng Chonglin Chen | 2018 | Journal of Materials Science & Technology2018，34，8： | 1 |
| 20 | BaCO3 modification of TiO2 electrodes in Quasi-Solid-State Dye-Sensitized Solar Cells:performance improvement and possible mechanism 显示文摘 | Wu Xueming Wang Liduo Luo Fen | 2007 | J Phys Chem C2007，111，22： | 1 |
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