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| 1 | Plumbagin suppresses chronic periodontitis in rats via down-regulation of TNF-α, IL-1β and IL-6 expression显示文摘长期的 periodontitis (CP ) 是最普通的口头的疾病之一,它在成年人引起牙槽的骨头吸收和牙齿损失。在我们试图调查 plumbagin (PL ) 的潜力的这研究,广泛地调查的活跃混合物在对待 CP 从繁体中文植物石墨 zeylanica L 提取了。人的牙齿周围的系带干细胞(PDLSC ) 在 vitro 被用于研究,而 CP 的一个动物模型被 ligation+Porphyromonas gingivalis (Pg ) 在 SD 老鼠建立刺激。老鼠与 PL 被注射(2, 4,和 6 mgs。在这研究,我们建立了 biomarkers 的焦点模式描绘 Gegen Qinlian 煎(GQD ) 的剂量效果关系,为对待类型 2 糖尿病 mellitus (2-DM ) 的一个 TCM 公式。2-DM 的一个老鼠模型通过喂的饮食与低剂量的 STZ 注射相结合的高脂肪被建立。有 2-DM 的老鼠是管理高度,中间或低剂量(6.785, 4.071, 1.357 mgl/L ) 在 vitro 引起了 glomerular podocyte apoptosis,它被无毒的 chrysin (1-20 mol/L ) dose-dependently 通过 DNA 的减小稀释破碎。Chrysin 处理 dose-dependently 恢复了增加的 Bax/Bcl-2 比率,并且在高暴露葡萄糖的肾的 podocytes 压制了 Apaf-1 正式就职和提高的细胞色素 c 版本。在糖尿病的 db/db 老鼠, chrysin 的口头的管理(10 mgf 1.84 ??? ?? | Xin-yi ZHENG Chuan-yuan MAO Han QIAO Xi ZHANG Li YU Ting-yu WANG Er-yi LU | 2017 | Acta Pharmacologica Sinica2017，38，8： | 22 |
| 2 | Effects of Short-Term Forest Bathing on Human Health in a Broad-Leaved Evergreen Forest in Zhejiang Province,China显示文摘Objective To investigate the effects of short-term forest bathing on human health.Methods Twenty healthy male university students participated as subjects and were randomly divided into two groups of 10.One group was sent on a two-night trip to a broad-leaved evergreen forest,and the other was sent to a city area.Serum cytokine levels reflecting inflammatory and stress response,indicators reflecting oxidative stress,the distribution of leukocyte subsets,and plasma endothelin-1 (ET-1) concentrations were measured before and after the experiment to evaluate the positive health effects of forest environments.A profile of mood states (POMS) evaluation was used to assess changes in mood states.Results No significant differences in the baseline values of the indicators were observed between the two groups before the experiment.Subjects exposed to the forest environment showed reduced oxidative stress and pro-inflammatory level,as evidenced by decreased malondialdehyde,interleukin-6,and tumor necrosis factor α levels compared with the urban group.Serum cortisol levels were also lower than in the urban group.Notably,the concentration of plasma ET-1 was much lower in subjects exposed to the forest environment.The POMS evaluation showed that after exposure to the forest environment,subjects had lower scores in the negative subscales,and the score for vigor was increased.Conclusion Forest bathing is beneficial to human health,perhaps through preventive effects related to several pathological factors. | MAO Gen Xiang LAN Xiao Guang CAO Yong Bao CHEN Zhuo Mei HE Zhi Huat LV Yuan Dong WANG Ya Zhen HU Xi Lian WANG Guo Fu YAN Jing | 2012 | Biomedical and Environmental Sciences2012，25，3： | 20 |
| 3 | Dual-Source Nuclear Monomers of UV-B Light Receptor Direct Photomorphogenesis in Arabidopsis显示文摘 | Qian, Chongzhen Mao, Weiwei Liu, Yan Ren, Hui Lau, On Sun Ouyang, Xinhao Huang, Xi | 2016 | Molecular Plant2016，9，12： | 14 |
| 4 | De novo mutation in ATP6V1B2 impairs lysosome acidification and causes dominant deafness-onychodystrophy syndrome显示文摘 | Yongyi Yuan Jianguo Zhang Qing Chang Jin Zeng Feng Xin Jianjun Wang Qingyan Zhu Jing Wu Jingqiao Lu Weiwei Guo Xukun Yan Hui Jiang Binfei Zhou Qi Li Xue Gao Huijun Yuan Shiming Yang Dongyi Han Zixu Mao Ping Chen Xi Lin Pu Dai | 2014 | Cell Research2014，24，11： | 13 |
| 5 | TALEN-based generation of a cynomolgus monkey disease model for human microcephaly显示文摘基因在非人类的首领编辑可以为在人探索病原学和遗传上基于的神经病学的混乱的治疗学的策略导致珍贵模型。然而,仔细在人模仿病理学、行为的赤字的神经病学的混乱的一个猴子模型成功地还没被产生了。Microcephalin 1 (MCPH1 ) 在人的大脑,和智力迟钝伴随的 MCPH1 变化原因头小畸型的进化被含有。这里,我们产生了用抄写带 biallelic MCPH1 变化的一只 cynomolgus 猴子(Macaca fascicularis ) 像使活跃之物的受动器核酸酶。猴子概括了大多数在病人观察的重要临床的特征,包括在头圆周,早熟的染色体冷凝作用(PCC ) ,语料库 callosum 的发育不全和上面的手足 spasticity 的显著减小。而且,在变异的真皮的成纤维细胞的 MCPH1 的 overexpression 救了 PCC 症候群。这个猴子模型可以帮助我们阐明在人的头小畸型并且更好的致病的 MCPH1 的角色在首领大脑尺寸的进化理解这蛋白质的功能。 | Qiong Ke Weiqiang Li Xingqiang Lai Hong Chen Lihua Huang Zhuang Kang Kai Li Jie Ren Xiaofeng Lin Haiqing Zheng Weijun Huang Yunhan Ma Dongdong Xu Zheng Chen Xinming Song Xinyi Lin Min Zhuang Tao Wang Fengfeng Zhuang Jianzhong Xi Frank Fuxiang Mao Huimin Xia Bruce T Lahn Qi Zhou Shihua Yang Andy Peng Xiang | 2016 | Cell Research2016，26，9： | 13 |
| 6 | Coordinated Transcriptional Regulation by the UVB Photoreceptor and Multiple Transcription Factors for Plant UV-B Responses显示文摘Non-damaging ultraviolet B(UV-B)light promotes photomorphogenic development and stress acclimation through UV-B-specific signal transduction in Arabidopsis.UV-B irradiation induces monomerization and nuclear translocation of the UV-B photoreceptor UV RESISTANCE LOCUS 8(UVR8).However,it is not clear how the nuclear localization of UVR8 leads to changes in global gene expression.Here,we reveal that nuclear UVR8 governs UV-B-responsive transcriptional networks in concert with several previously known transcription factors,including ELONGATED HYPOCOTYL 5(HY5)and PHYTOCHROME INTERACTING FACTOR 4(PIF4).Based on the transcriptomic analysis,we identify MYB13 as a novel positive regulator in UV-B-induced cotyledon expansion and stress acclimation.MYB13 is UV-B inducible and is predominantly expressed in the cotyledons.Our results demonstrate that MYB13 protein functions as a transcription factor to regulate the expression of genes involved in auxin response and flavonoid biosynthesis through direct binding with their promoters.In addition,photoactivated UVR8 interacts with MYB13 in a UV-B-dependent manner and differentially modulates the affinity of MYB13 with its targets.Taken together,our results elucidate the cooperative function of the UV-B photoreceptor UVR8 with various transcription factors in the nucleus to orchestrate the expression of specific sets of downstream genes and,ultimately,mediate plant responses to UV-B light. | Chongzhen Qian Zhiren Chen Qing Liu Weiwei Mao Yanling Chen Wei Tian Yan Liu Jiupan Han Xinhao Ouyang Xi Huang | 2020 | Molecular Plant2020，13，5： | 13 |
| 7 | Ultrasonic-assisted Oxidation Leaching of Nickel Sulfide Concentrate显示文摘The feasibility of oxidation leaching process of nickel from nickel sulfide ore and the form of different components in the lixivium has been studied at first. The method of leaching nickel sulfide concentration directly by oxidants with existence of ultrasonic has been advanced. The process of leaching nickel from nickel sulfide concentration by using the system of persulfate and silver has been determined. The influence of different factors on the leaching rates of nickel,such as with and without ultrasonic,the concentration of Na2S2O8,liquid-solid ratio and the concentration of AgNO3 have been explored. The results show that:(1) in the oxidative leaching system,nickel can be leached completely as Ni2+ or NiSO4(aq.) from nickel sulfide concentration in theory;(2) the nicopyrite can not exist steadily in the persulfate acid leaching system,but Ni2+can. Meanwhile,sulfur may be existed steadily in the leaching process;(3) nicopyrite with much lower electrostatic potential may be leached earlier than chalcopyrite and sideropyrite;and(4) the overall reaction rate of the leaching process can be enhanced with ultrasonic radiation,but it does not change the mechanism of leaching. The more oxidant concentration or higher liquid-solid ratio is,the higher leaching percentage of nickel. The leaching percentage of nickel can be increased significantly by adding a small amount of AgNO3 during the leaching processes. Under the same conditions,the higher concentration of AgNO3 is,the higher leaching yields of nickel will be obtained. | XUE Juanqin LU Xi DU Yewei MAO Weibo WANG Yujie LI Jingxian | 2010 | Chinese Journal of Chemical Engineering2010，18，6： | 12 |
| 8 | Effect of Cyclocarya paliurus polysaccharides on streptozotocin-induced diabetic nephropathy in rats显示文摘OBJEVTIVE:To investigate the efficacy of Cyclocarya paliurus(C.paliurus)polysaccharides on streptozotocin-induced diabetic nephropathy in rats.METHODS:Rats were divided into 6 groups,including group of normal control,group of diabetic control,group of metformin treatment,low-dose group of C.paliurus polysaccharides treatment,middle-dose group of C.paliurus polysaccharides treatment and high-dose group of C.paliurus polysaccharides treatment.Histological analysis of kidney was analyzed using hematoxilin and eosin.Levels of blood glucose,creatinine,urea,uric acid were determined by spectrophotometry.Anti-oxidative enzymes were measured by real-time polymerase chain reaction(PCR)and enzyme-linked immunosorbent assay(ELISA).Advanced glycation end products(AGEs)and transforming growth factor-β1(TGF-β1)level was measured by ELISA.RESULTS:Abnormal changes were observed in the group of diabetic control characterized by atrophy of the renal glomeruli with hypercellularity,congestion of glomerular tufts,dilation of the renal spaces,and degeneration of renal tubule.Compared with that of normal group,blood glucose,creatinine,urea,uric acid level was significantly increased in the group of diabetic control.Superoxide dismutase,catalase,glutathione peroxidase,glutathione reductase level was significantly decreased,but AGEs and TGF-β1 level was significantly increased.By contrast,administration of C.paliurus polysaccharides and metformin could reverse the above-mentioned results of the group of diabetic control,especially in the high-dose group of C.paliurus polysaccharides.CONCLUSION:Our findings suggest that C.paliurus polysaccharides may play a protecting role for nephropathy of diabetic rats by lowering glucose,creatinine,urea,uric acid level,enhancing the antioxidative ability,and reducing AGEs and TGF-β1 expression. | Xia Xichao Mao Dongxue Dai Hongmei Wu Xi Zhang Zuyuan Wang Huaying Zhou Wenwen Dong Yanmei Wang Mengqi Li Yuan Shao Xiangyang Ouyang Jingfeng | 2020 | Journal of Traditional Chinese Medicine2020，40，6： | 9 |
| 9 | Highly expressed BMP9/GDF2 in postnatal mouse liver and lungs may account for its pleiotropic effects on stem cell differentiation,angiogenesis,tumor growth and metabolism显示文摘Bone morphogenetic protein 9(BMP9)(or GDF2)was originally identified from fetal mouse liver cDNA libraries.Emerging evidence indicates BMP9 exerts diverse and pleiotropic functions during postnatal development and in maintaining tissue homeostasis.However,the expression landscape of BMP9 signaling during development and/or in adult tissues remains to be analyzed.Here,we conducted a comprehensive analysis of the expression landscape of BMP9 and its signaling mediators in postnatal mice.By analyzing mouse ENCODE transcriptome datasets we found Bmp9 was highly expressed in the liver and detectable in embryonic brain,adult lungs and adult placenta.We next conducted a comprehensive qPCR analysis of RNAs isolated from major mouse tissues/organs at various ages.We found that Bmp9 was highly expressed in the liver and lung tissues of young adult mice,but decreased in older mice.Interestingly,Bmp9 was only expressed at low to modest levels in developing bones.BMP9-associated TGFβ/BMPR type I receptor Alk1 was highly expressed in the adult lungs.Furthermore,the feedback inhibitor Smads Smad6 and Smad7 were widely expressed in mouse postnatal tissues.However,the BMP signaling antagonist noggin was highly expressed in fat and heart in the older age groups,as well as in kidney,liver and lungs in a biphasic fashion.Thus,our findings indicate that the circulating BMP9 produced in liver and lungs may account for its pleiotropic effects on postnatal tissues/organs although possible roles of BMP9 signaling in liver and lungs remain to be fully understood. | Wei Liu Zhongliang Deng Zongyue Zeng Jiaming Fan Yixiao Feng Xi Wang Daigui Cao Bo Zhang Lijuan Yang Bin Liu Mikhail Pakvasa William Wagstaff Xiaoxing Wu Huaxiu Luo Jing Zhang Meng Zhang Fang He Yukun Mao Huiming Ding Yongtao Zhang Changchun Niu Rex C.Haydon Hue H.Luu Jennifer Moriatis Wolf Michael J.Lee Wei Huang Tong-Chuan He Yulong Zou | 2020 | Genes & Diseases2020，7，2： | 9 |
| 10 | Pulsatile gonadotropin-releasing hormone therapy is associated with earlier spermatogenesis compared to combined gonadotropin therapy in patients with congenital hypogonadotropic hypogonadism显示文摘 | Jiang-Feng Mao Zhao-Xiang Liu Min Nie Xi Wang Hong-Li Xu Bing-Kun Huang Jun-Jie Zheng Le Min Ursula Brigitte Kaiser Xue-Yan Wu | 2017 | Asian Journal of Andrology2017，19，6： | 8 |
| 11 | INFLUENCE OF STRUCTURE ON HYDRAULIC CHARACTERISTICS OF T SHAPE FISHWAY显示文摘While dams cut off the migratory route of fish, and affect their growth and breeding, fishways are built to restore the connectivity of rivers and facilitate the life cycle of these migratory fish. This paper proposes a new kind of fishway called the 'T shape fishway', and studies it by using both numerical simulations and physical experimental methods with the aim to design a fishway in China for migratory fish with swimming and jumping capability much poorer, such as schizothorax davidi and schizothorax prenanti, as compared with migratory fish in other places of the world, like trout and salmon. It is indicated that the range of velocity in each regular pool of the T shape fishway is from 0.42 m/s to 1.22 m/s when the flow discharge Q is 350 L/s, and there are no large vortex zones found there. This study shows that the T shape fishway can meet the requirements of these migratory fish quite well in terms of velocity and flow patterns in China. | MAO Xi FU Jing-jing TUO You-cai AN Rui-dong LI Jia | 2012 | Journal of Hydrodynamics2012，24，5： | 7 |
| 12 | A wheat gene Ta SAP17-D encoding an AN1/AN1 zinc finger protein improves salt stress tolerance in transgenic Arabidopsis显示文摘The stress-associated protein(SAP) multigene family is conserved in both animals and plants. Its function in some animals and plants are known, but it is yet to be deciphered in wheat(Triticum aestivum L.). We identified the wheat gene Ta SAP17-D, a member of the SAP gene family with an AN1/AN1 conserved domain. Subcellular localization indicated that TaS AP17-D localized to the nucleus, cytoplasm, and cell membrane. Expression pattern analyses revealed that TaS AP17-D was highly expressed in seedlings and was involved in Na Cl response, polyethylene glycol(PEG), cold, and exogenous abscisic acid(ABA). Constitutive expression of TaS AP17-D in transgenic Arabidopsis resulted in enhanced tolerance to salt stress, confirmed by improved multiple physiological indices and significantly upregulated marker genes related to salt stress response. Our results suggest that Ta SAP17-D is a candidate gene that can be used to protect crop plants from salt stress. | XU Qiao-fang MAO Xin-guo WANG Yi-xue WANG Jing-yi XI Ya-jun JING Rui-lian | 2018 | Journal of Integrative Agriculture2018，17，3： | 7 |
| 13 | Realization of quantum discrete Fourier transform with NMR显示文摘The pulse sequences of the logic operations used in quantum discrete Fourier transform are designed for the experiment of nuclear magnetic resonance(NMR), and 2-qubit discrete Fourier transforms are implemented experimentally with NMR. The experimental errors are examined and methods for reducing the errors are proposed. | FANG Ximing ZHU Xiwen FENG Mang MAO Xi’an DU Fei | 2000 | Chinese Science Bulletin2000，45，12： | 7 |
| 14 | Admission Glucose and In-hospital Mortality after Acute Myocardial Infarction in Patients with or without Diabetes: A Cross-sectional Study显示文摘 | Shi Zhao Karthik Murugiah Na Li Xi Li Zi-Hui Xu Jing Li Chen Cheng Hong Mao Nicholas S Downing Harlan M Krumholz Li-Xin Jiang | 2017 | Chinese Medical Journal2017，，7： | 6 |
| 15 | A draft sequence of the rice (Oryza sativa ssp. indica) genome显示文摘The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a 'whole genome shotgun' approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in China and many other regions of Asia. The draft genome sequence is constructed from over 4.3 million successful sequencing traces with an accumulative total length of 2214.9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 million successful sequencing traces with a total length of 1797.4 Mb from an indica variant cultivar 93-11, giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software package | YU Jun, HU Songnian, WANG Jun,LI Songgang WONG Ka-Shu Gane, LIU Bin,DENG Yajun, DAI Li, ZHOU Yan,ZHANG Xiuqing, CAO Mengliang, LIU Jing,SUN Jiandong , TANG Jiabin, CHEN Yanjiong,HUANG Xiaobing, LIN Wei, YE Chen, TONG Wei,CONG Lijuan, GENG Jianing, HAN Yujun, LI Lin,LI Wei, HU Guangqiang, HUANG Xiangang,LI Wenjie, LI Jian, LIU Zhanwei, LI Long,LIU Jianping, Ql Qiuhui, LIU Jinsong, LI Li,WANG Xuegang, LU Hong, WU Tingling,ZHU Miao, Nl Peixiang, HAN Hua, DONG Wei,REN Xiaoyu, FENG Xiaoli, GUI Peng,LI Xianran, WANG Hao, XU Xin, ZHAI Wenxue,XU Zhao, ZHANG Jinsong, HE Sijie,ZHANG Jianguo, XU Jichen, ZHANG Kunlin,ZHENG Xianwu, DONG Jianhai, ZENG Wanyong,TAO Lin, CHEN Xuewei, HE Jun, LIU Daofeng,TIAN Wei, TIAN Chaoguang, XIA Hongai,LI Gang, GAO Hui, LI Ping, CHEN Wei ,WANG Xudong, ZHANG Yong, HU Jianfei,WANG Jing, LIU Song, YANG Jian,ZHANG Guangyu, XIONG Yuqing, LI Zhijie,MAO Long, ZHOU Chengshu, ZHU Zhen,CHEN Runsheng, HAO Bailin,ZHENG Weimou, CHEN Shouyi, QUO Wei,LI Guojie, LIU Siqi, HUANG Guyang,TAO Ming, WANG Jian, ZHU Lihuang,YUAN Longping& YANG HuanmingBeijing Genomics Institute/Center of Genomics & Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, China Institute of Genetics, Chinese Academy of Sciences, Beijing 100101, China National Hybrid Rice R & D Center, Changsha 410125, China Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China College of Life Sciences, Peking University, Beijing 100871, China Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 1Q0080, China Digital China Ltd., Beijing 100080, China Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China Medical College, Xi’an Jiaotong University, Xi’an 710061, ChinaThese authors contributed equally to this work.Corresponding author.Corresponden | 2001 | Chinese Science Bulletin2001，46，23： | 6 |
| 16 | Electroless plating of copper layer on surfaces of urea-formaldehyde microcapsule particles containing paraffin for low infrared emissivity显示文摘 | Xi Zhou Jian Mao Zhen Qiao | 2016 | Particuology2016，14，1： | 5 |
| 17 | Pore Characteristics of the Fine-Grained Tight Reservoirs in the Yabulai Basin, Northwestern China显示文摘This work investigated the pore structure characteristics and reservoir features of the finegrained tight reservoirs in the lower member of the Xinhe Formation(J_2 x_1) in the Xiaohu subsag,Yabulai Basin based on core samples through various techniques. Interbedded silt/fine sandstones and mudstones are developed in the study area. Scanning electron microscopy(SEM) images were used to delineate different types of pores, including primary intergranular pores, secondary intergranular and intragranular pores, organic pores and fractures. The pore types were distinguished by pore size, pore area, location and formation process. The pore radii of the fine-grained rocks range from 1 nm to 1.55μm, mainly concentrated between 5 and 300 nm by low pressure N_2 adsorption and MICP analyses. The pore structure parameters of pore throat size and pore throat sorting coefficient are both positively correlated with porosity, while pore throat sorting coefficient has a negative correlation with permeability. The pore structures of the studied samples are much related to the mineral type and content and grain size, followed by TOC content. In these rocks with relatively low TOC and low maturity, the rigid minerals protect pores with pressure shadow from collapse, and dissolution-related pores contribute a lot to inorganic porosity. In contrast, these rocks with abundant TOC contain a large number of organic pores. The permeability of the fine-grained tight reservoir is mainly dominated by larger pore throats, while a large number of small pores(mostly <0.1 μm) contribute considerably to porosity. These results have deepened our understanding of the interbedded fine-grained tight reservoirs and can be applicable to fine-grained reservoirs in a similar setting. | ZHANG Shaomin CAO Yingchang Jens JAHREN ZHU Rukai MAO Zhiguo XI Kelai Kashif MUHAMMAD Helge HELLEVANG | 2018 | Acta Geologica Sinica(English Edition)2018，92，3： | 5 |
| 18 | Magnolol protects against acute gastrointestinal injury in sepsis by down-regulating regulated on activation,normal T-cell expressed and secreted显示文摘BACKGROUND Sepsis is a major medical challenge.Magnolol is an active constituent of Houpu that improves tissue function and exerts strong anti-endotoxin and anti-inflammatory effects,but the mechanism by which it reduces intestinal inflammation in sepsis is yet unclear.AIM To assess the protective effect of magnolol on intestinal mucosal epithelial cells in sepsis and elucidate the underlying mechanisms.METHODS Enzyme-linked immunosorbent assay was used to measure tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),IL-6,and regulated on activation,normal T-cell expressed and secreted(RANTES)levels in serum and ileal tissue in animal studies.The histopathological changes of the ileal mucosa in different groups were observed under a microscope.Cell Counting Kit-8 and cell permeability assays were used to determine the concentration of drug-containing serum that did not affect the activity of Caco2 cells but inhibited lipopolysaccharide(LPS)-induced decrease in permeability.Immunofluorescence and Western blot assays were used to detect the levels of RANTES,inhibitor of nuclear factor kappa-B kinaseβ(IKKβ),phosphorylated IKKβ(p-IKKβ),inhibitor of nuclear factor kappa-B kinaseα(IκBα),p65,and p-p65 proteins in different groups in vitro.RESULTS In rats treated with LPS by intravenous tail injection in the presence or absence of magnolol,magnolol inhibited the expression of proinflammatory cytokines,IL-1β,IL-6,and TNF-αin a dose-dependent manner.In addition,magnolol suppressed the production of RANTES in LPS-stimulated sepsis rats.Moreover,in vitro studies suggested that magnolol inhibited the increase of p65 nucleation,thereby markedly downregulating the production of the phosphorylated form of IKKβin LPS-treated Caco2 cells.Specifically,magnolol inhibited the translocation of the transcription factor nuclear factor-kappa B(NF-κB)from the cytosol into the nucleus and down-regulated the expression level of the chemokine RANTES in LPS-stimulated Caco2 cells.CONCLUSION Magnolol down-regulates RANTES levels by inhibiting the LPS/NF-κB signaling pathways,thereby suppressing IL-1β,IL-6,and TNF-αexpression to alleviate the mucosal barrier dysfunction in sepsis. | Shi-Hao Mao Dan-Dan Feng Xi Wang Yi-Hui Zhi Shu Lei Xi Xing Rong-Lin Jiang Jian-Nong Wu | 2021 | World Journal of Clinical Cases2021，9，34： | 5 |
| 19 | Primary malignant lymphoma of the glans penis: a rare :ase report and review of the literature显示文摘 | Li Chu Wei Mao Kim Curran Vikramsingh Xi Liu Hui-Min Qiu jun-Hua Zheng Yi Wang Gen-Pei Yu Qing Xu | 2013 | Asian Journal of Andrology2013，15，4： | 4 |
| 20 | Modeling multilook polarimetric SAR images with heavy-tailed rayleigh distribution and novel estimation based on matrix log-cumulants显示文摘With the improvements in modern radar resolution,the Gaussian-fluctuation model based on the central limit theorem does not accurately describe the scattering echo from targets.In contrast,the heavytailed Rayleigh distribution,based on the generalized central limit theorem,performs well in modeling the synthetic aperture radar(SAR) images,whereas its application to multi-look image processing is difficult.We describe successful modeling of multilook polarimetric SAR images with the heavy-tailed Rayleigh distribution and present novel parameter estimators based on matrix log-cumulants for the heavy-tailed Rayleigh distribution including the equivalent number of looks(ENL).First,a compound variable of heavy-tailed Rayleigh distribution is divided into a product of a positive alpha-stable variable and a complex Gaussian variable.The parameter estimations of the characteristic exponent and scale parameter based on log-cumulants in a single polarization channel are then derived.Second,the matrix log-cumulants(MLCs) for full polarization in multilook images are obtained,which can be applied to estimate model parameters.Therefore,a novel ENL estimator based on MLC is presented that describes the model more precisely.Extended to all other multivariable product models,this estimator performs better than existing methods.Finally,calculations on both simulated and real data are performed that give good fits with theoretical results.Multilook processing in one image with a fixed pixel number can improve parameter estimations over single-look processing.Our heavy-tailed Rayleigh model with its parameter estimation provides a new method to analyze the multilook polarimetric SAR images for target detection and classification. | LIU Tao CUI HaoGui MAO Tao XI ZeMin GAO Jun | 2013 | Science China(Information Sciences)2013，56，6： | 4 |
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