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| 1 | The role of provenance in the diagenesis of siliciclastic reservoirs in the Upper Triassic Yanchang Formation,Ordos Basin,China显示文摘A better understanding of the controls on reservoir quality has become essential in the petroleum exploration in recent years.Determining the original composition of the sediment framework is important not only for paleogeographic reconstructions,but it is also vital for predicting the nature of physical and chemical diagenesis of the potential reservoirs.Depositional setting and diagenesis are important factors in controlling the type and quality of most siliciclastic reservoirs.We studied the Upper Triassic Chang 8 and 6 members,where the relationship between sediment provenance and diagenesis was examined.The study attempts to clarify sediment provenance and post-depositional diagenetic modifications of the sandstones through systematic analytical methods including petrographic macro-and microscopic analysis of grain and heavy mineral types,and measurements of the palaeocurrent direction of the Yanchang Formation sediments in the outcrops in order to determine the provenance of the studied sediments.Furthermore,the relationship between framework grains,pore types and diagenesis of the sediments was analyzed by thin section petrographic characterization using a polarizing microscope.Additionally,a JEOL JSM-T330 scanning electron microscope(SEM) equipped with a digital imaging system was used to investigate the habits and textural relationships of diagenetic minerals.On the basis of our results,we believe that sediment provenance is a significant factor which controls the type and degree of diagenesis which may be expected in sandstones.In the Chang 8 and 6 members,the formation of chlorite rims and laumontite cement was observed where volcanic rock fragments constitute a large part of the framework grains.Furthermore,high biotite content provides abundant iron and magnesium and enables the formation of chlorite rims due to biotite hydrolysis.In addition,ductile deformation of biotite leads to strong mechanical compaction of the sediments.Conversely,high feldspar content diminishes the degree of mechanical compaction,however the dissolution of feldspar minerals in sandstones is commonly observed.Apart from feldspars,quartz and other rigid framework grains highly control the degree of mechanical compaction during the initial stage of burial(0-2 km). | Ding Xiaoqi Han Meimei Zhang Shaonan | 2013 | Petroleum Science2013，10，2： | 16 |
| 2 | Curcumin protects against ischemic spinal cord injury The pathway effect显示文摘Inducible nitric oxide synthase and N-methyl-D-aspartate receptors have been shown to participate in nerve cell injury during spinal cord ischemia.This study observed a protective effect of curcumin on ischemic spinal cord injury.Models of spinal cord ischemia were established by ligating the lumbar artery from the left renal artery to the bifurcation of the abdominal aorta.At 24 hours after model establishment,the rats were intraperitoneally injected with curcumin.Reverse transcription-polymerase chain reaction and immunohistochemical results demonstrated that after spinal cord ischemia,inducible nitric oxide synthase and N-methyl-D-aspartate receptor mRNA and protein expression significantly increased.However,curcumin significantly decreased inducible nitric oxide synthase and N-methyl-D-aspartate receptor mRNA and protein expression in the ischemic spinal cord.Tarlov scale results showed that curcumin significantly improved motor function of the rat hind limb after spinal cord ischemia.The results demonstrate that curcumin exerts a neuroprotective effect against ischemic spinal cord injury by decreasing inducible nitric oxide synthase and N-methyl-D-aspartate receptor expression. | Jinhua Zhang Hao Wei Meimei Lin Chunmei Chen Chunhua Wang Maobai Liu | 2013 | Neural Regeneration Research2013，8，36： | 9 |
| 3 | Silicon lithium-ion battery anode with enhanced performance: Multiple effects of silver nanoparticles显示文摘Silicon has been regarded as one of the most promising next generation lithium-ion battery anode. However, the poor cyclic stability of the Si based anode has severely limited its practical applications, which is even worse with high mass loading density(>1 mg cm^(-2)). A new concept has been developed to enhance the electrochemical performance of the Si nanoparticle anode. Silver nanoparticles are composited with the silicon nanoparticles in a facile way for the first time. It is found that the mechanical properties of the Si electrode have been significantly improved by the incorporation of the silver nanoparticles, leading to enhanced cyclic performance. With the Si/Ag mass ratio of 4:1, the reversible specific discharge capacity is retained as 1156 m A h g^(-1) after 100 cycles at 200 mA g^(-1), which is more than three times higher than that of the bare silicon(318 mA h g^(-1)). The rate performance has been effectively improved as well due to excellent electron conductivity of the silver nanoparticles. | Shanshan Yin Qing Jia Xiuxia Zuo Shuang Xie Kai Fang Yonggao Xia Jinlong Li Bao Qiu Meimei Wang Jianzhen Ban Xiaoyan Wang Yi Zhang Ying Xiao Luyao Zheng Suzhe Liang Zhaoping Liu Cundong Wang Ya-Jun Cheng | 2018 | Journal of Materials Science & Technology2018，34，10： | 4 |
| 4 | Experimental investigation on dilatancy behavior of water-saturated sandstone显示文摘It is important to study the dilatancy property of water-saturated rock for understanding the engineering behavior of loaded rock mass. This study carried out the uniaxial and triaxial compressive experiments on the water-saturated red sandstone, analyzed the influences of confining pressure and pore pressure on dilatancy property of water-saturated rock, and discussed the reasonable basis of the stress of dilatancy onset as a strength design parameter of rock engineering, finally established the prediction model of the stress of dilatancy onset under the impacts of confining pressure and pore pressure. The results show that the strength parameters(the stress of dilatancy onset and peak strength) and deformation parameters(axial strain and circumferential strain) of water-saturated sandstone increase with the confining pressure, and the relations can be fitted with a positive linear function. The cohesion and internal friction angle obtained from the stress of dilatancy onset decrease by 11.57% and 7.33%, respectively, when compared with those obtained from the peak strength. The strength parameters and deformation parameters of water-saturated sandstone decrease basically with the increase of pore pressure, in which the relations between strength parameters or axial strain and pore pressure can be fitted with a negative linear function. However, the relation between the peak circumferential strain and the pore pressure should be characterized by a negative exponential function, and the circumferential strain at dilatancy onset isn't affected by the pore pressure. | Jiangyu Wu Meimei Feng Bangyong Yu Wenli Zhang Xiaoyan Ni Guansheng Han | 2018 | International Journal of Mining Science and Technology2018，28，2： | 4 |
| 5 | Schisandrol A protects AGEs-induced neuronal cells death by allosterically targeting ATP6V0d1 subunit of V-ATPase显示文摘Diabetes have been shown to cause progressive neuronal injury with pain and numbness via advanced glycation end-products(AGEs)-induced neuronal cell apoptosis;however, the valuable drug targets for diabetic neuropathy have been poorly reported so far. In this study, we discovered a natural small-molecule schisandrol A(SolA) with significant protective effect against AGEs-induced neuronal cell apoptosis. ATP6V0D1, a major subunit of vacuolar-type ATPase(V-ATPase) in lysosome was identified as a crucial cellular target of SolA. Moreover, SolA allosterically mediated ATP6V0D1 conformation via targeting a unique cysteine 335 residue to activate V-ATPase-dependent lysosomal acidification.Interestingly, SolA-induced lysosome pH downregulation resulted in a mitochondrial-lysosomal crosstalk by selectively promoting mitochondrial BH3-only protein BIM degradation, thereby preserving mitochondrial homeostasis and neuronal cells survival. Collectively, our findings reveal ATP6V0D1 is a valuable pharmacological target for diabetes-associated neuronal injury via controlling lysosomal acidification, and also provide the first small-molecule template allosterically activating V-ATPase for preventing diabetic neuropathy. | Xiaoqing Zhou Shaoyang Zhao Tingting Liu Lu Yao Meimei Zhao Xiaoming Ye Xiaowen Zhang Qiang Guo Pengfei Tu Kewu Zeng | 2022 | Acta Pharmaceutica Sinica B2022，12，10： | 3 |
| 6 | Additive-free non-fullerene organic solar cells with random copolymers as donors over 9% power conversion efficiency显示文摘In this study, a series of random conjugated polymers (PBDB-TBTn) as donors were designed and synthesized. In these polymers, benzodithiophene unit with thiophene conjugated side chains (BDT) are donor part, and two different content of benzo[1,2-c:4,5-c']dithiophene-4,8-dione (BDD) and difluorobenzothiadizole (BT) linked alkylthiophene are acceptor unit. Polymer solar cells (PSCs) were fabricated with ITIC as an acceptor, and over the power conversion efficiency (PCE) of 9%was obtained, with open circuit voltage (Voc) of 0.86 V, short-circuit current density (Jsc) of 16.84 mA/cm^2, and fill factor (FF) of 62.5%. These random conjugated polymers based solar cells are insensitive to solvent additives and thermal annealing. The performance of the device decreases gradually with the increasing of the proportion of fluorinated acceptor unit. The declining efficiency is due to the excessive fluorinated acceptor unit, which leads to over aggregated topography, destroys the effective charge transport pathways, and affects phase separation domain size between the donor and the acceptor. The phenomena are explained by the charge carrier recombination, atomic force microscope (AFM), and transmission electron microscope (TEM). These results indicate that proper addition of fluorinated acceptor units to build random copolymers can enhance the efficiency of organic photovoltaics toward additive-free and thermal annealing-free PSCs. | Meimei Wu Laitao Shi Yu Hu Lie Chen Ting Hu Youdi Zhang Zhongyi Yuan Yiwang Chen | 2019 | Chinese Chemical Letters2019，30，6： | 3 |
| 7 | Optimization of a doxycycline hydroxypropyl-β-cyclodextrin inclusion complex based on computational modeling显示文摘To prepare a stable complex of doxycycline(Doxy)and hydroxypropy-β-cyclodextrin(HP-β-CD)for ophthalmic delivery,the optimum formulation and preparation conditions were investigated using response surface methodology(RSM),artificial neural network(ANN)and support vector machine(SVM)modeling.The molar ratios of HP-β-CD/Doxy and Mg^(2+)/Doxy,inclusion time and temperature were selected as independent variables (X_(1)-X_(4)) and inclusion efficiency and stability of the Doxy-HP-β-CD complex were selected as dependent(response)variables(Y_(1) and Y_(2)).The optimal formulation predicted by genetic algorithm(GA)combined with the models was characterized by microscopy and nuclear magnetic resonance spectrometry,and the stability of Doxy in the complex was evaluated.The highest values of Y_(1) and Y_(2) were obtained using an ANN model combined with GA which predicted the values of X_(1)-X_(4) to be 4,10.8,12 h and 25℃,respectively.The modeling and optimization results indicated that a feed-forward back-propagation ANN with one hidden layer and 10 hidden units showed better fitting to both responses compared to the RSM and SVM models.GA proved to be an efficient tool in multiobjective optimization of a pharmaceutical formulation. | Zhouhua Wang Zixin He Lei Zhang Haohao Zhang Meimei Zhang Xinguo Wen Guilan Quan Xintian Huang Xin Pan Chuanbin Wu | 2013 | Acta Pharmaceutica Sinica B2013，3，2： | 2 |
| 8 | Generation of selectable marker-free soft transgenic rice with transparent kernels by downregulation of SSSⅡ-2显示文摘The amylose content(AC)of rice endosperm starch varies from 0 to 35%,and is associated with rice cooking and eating quality.Soft rice has low AC,generally between 6%and 15%,and its eating quality is high whether it is consumed hot or cold.However,the appearance quality of current soft rice cultivars needs to be improved,especially opaque endosperm.Conventional genetic engineering has improved some agronomic traits of soft rice varieties,but not endosperm appearance.In the present study,a RNAi construct of the soluble starch synthase II-2(SSSII-2)and the hygromycin phosphotransferase(HPT)gene were introduced into an elite japonica rice variety,Kangtiaowuyunjing(KWY8)by co-transformation.Several selectable marker-free(SMF)transgenic lines were obtained,and SSSII-2 expression was significantly downregulated in selected transgenic lines,resulting in lower AC of the endosperm.The physicochemical properties of the transgenic rice kernels,including gel consistency(GC)and rapid visco analyzer(RVA)profile,differed significantly from those of wild-type rice and were similar to those of a soft rice variety,Nanjing 46(NJ46).These findings indicate that the cooking,eating,and processing qualities of transgenic rice are comparable to those of NJ46.However,the transgenic rice endosperm retained a transparent appearance under low-moisture conditions.Thus,SMF SSSII-2 RNAi rice provides a resource for breeding soft rice with transparent endosperm. | Zhihao Xu Meimei Yu Youwei Yin Cenwen Zhu Wen Ji Changquan Zhang Qianfeng Li Honggen Zhang Shuzu Tang Hengxiu Yu Qiaoquan Liu | 2020 | The Crop Journal2020，8，1： | 2 |
| 9 | Yin Yang 1 Plays an Essential Role in Breast Cancer and Negatively Regulates p27显示文摘 | Meimei Wan Weiwei Huang Timothy E. Kute Lance D. Miller Qiang Zhang Heather Hatcher Jingxuan Wang Daniel B. Stovall Gregory B. Russell Paul D. Cao Zhiyong Deng Wei Wang Qingyuan Zhang Ming Lei Suzy V. Torti Steven A. Akman Guangchao Sui | 2012 | The American Journal of Pathology2012，，： | 1 |
| 10 | A chromosome-scale reference genome of Aquilegia oxysepala var.kansuensis显示文摘The genus Aquilegia(Ranunculaceae)has been cultivated as ornamental and medicinal plants for centuries.With petal spurs of strikingly diverse size and shape,Aquilegia has also been recognized as an excellent system for evolutionary studies.Pollinator‐mediated selection for longer spurs is believed to have shaped the evolution of this genus,especially the North American taxa.Recently,however,an opposite evolutionary trend was reported in an Asian lineage,where multiple origins of mini-or even nonspurred morphs have occurred.Interesting as it is,the lack of genomic resources has limited our ability to decipher the molecular and evolutionary mechanisms underlying spur reduction in this special lineage.Using long-read sequencing(PacBio Sequel),in combination with optical maps(BioNano DLS)and Hi–C,we assembled a high-quality reference genome of A.oxysepala var.kansuensis,a sister species to the nonspurred taxon.The final assembly is approximately 293.2 Mb,94.6%(277.4 Mb)of which has been anchored to 7 pseudochromosomes.A total of 25,571 protein-coding genes were predicted,with 97.2%being functionally annotated.When comparing this genome with that of A.coerulea,we detected a large rearrangement between Chr1 and Chr4,which might have caused the Chr4 of A.oxysepala var.kansuensis to partly deviate from the“decaying”path that was taken before the split of Aquilegia and Semiaquilegia.This high-quality reference genome is fundamental to further investigations on the development and evolution of petal spurs and provides a strong foundation for the breeding of new horticultural Aquilegia cultivars. | Jinghe Xie Haifeng Zhao Kunpeng Li Rui Zhang Yongchao Jiang Meimei Wang Xuelian Guo Ben Yu Hongzhi Kong Yuannian Jiao Guixia Xu | 2020 | Horticulture Research2020，7，1： | 1 |
| 11 | Antibacterial mechanism of kojic acid and tea polyphenols against Escherichia coli O157:H7 through transcriptomic analysis显示文摘Escherichia coli O157:H7 is one of the major foodborne pathogenic bacterial that cause infectious diseases in humans.The previous found that a combination of kojic acid and tea polyphenols exhibited better activity against E.coli O157:H7 than using either alone.This study aimed to explore responses underlying the antibacterial mechanisms of kojic acid and tea polyphenols from the gene level.The functional enrichment analysis by comparing kojic acid and tea polyphenols individually or synergistically against E.coli O157:H7 found that acid resistance systems in kojic acid were activated,and the cell membrane and genomic DNA were destructed in the cells,resulting in“oxygen starvation”.The oxidative stress response triggered by tea polyphenols inhibited both sulfur uptake and the synthesis of ATP,which affected the bacteria's life metabolic process.Interestingly,we found that kojic acid combined with tea polyphenols hindered the uptake of iron that played an essential role in the synthesis of DNA,respiration,tricarboxylic acid cycle.The results suggested that the iron uptake pathways may represent a novel approach for kojic acid and tea polyphenols synergistically against E.coli O157:H7 and provided a theoretical basis for bacterial pathogen control in the food industry. | Yilin Lin Ruifei Wang Xiaoqing Li Keren Agyekumwaa Addo Meimei Fang Yehui Zhang Yigang Yu | 2024 | Food Science and Human Wellness2024，13，2： | 1 |
| 12 | Quantitative study on hydrocarbon expulsion mechanism based on micro-fracture显示文摘The significance of source rocks for oil and gas accumulation has been indisputably acknowledged.Moreover,it has been gradually realized that there is difference between hydrocarbon generation capacity and hydrocarbon expulsion capacity,and this has prompted research on hydrocarbon expulsion efficiency.However,these studies dominantly highlight the results of hydrocarbon expulsion,and investigation into the corresponding process and mechanism is primarily from a macroscopic perspective.Despite its wide acceptance as the most direct hydrocarbon expulsion mode,hydrocarbon expulsion through micro-fractures is still not sufficiently understood.Therefore,this study obtains observations and performs experiments on two types of source rocks(mudstones and shales)of the Chang 7 oil group of the Yanchang Formation in Ordos Basin,China.Microscopy reveals that organic matter is non-uniformly distributed in both types of source rocks.Specifically,mudstones are characterized by a cluster-like organic matter distribution,whereas shales are characterized by a layered organic matter distribution.Thermal evolution simulation experiments demonstrate that the hydrocarbon generation process is accompanied by the emergence of micro-fractures,which are favorable for hydrocarbon expulsion.Moreover,based on the theories of rock physics and fracture mechanics,this study establishes micro-fracture development models for both types of source rocks,associated with the calculation of the fracture pressure that is needed for the initiation of fracture development.Furthermore,the relationship between the fluid pressure,fracture pressure,and micro-fracture expansion length during micro-fracture development is quantitatively explored,which helps identify the micro-fracture expansion length.The results indicate that the development of micro-fractures is commonly impacted by the morphology and distribution pattern of the organic matter as well as the mechanical properties of the source rocks.The micro-fractures in turn further affect the hydrocarbon expulsion capacity of the source rocks.The results of this study are expected to provide theoretical and practical guidance for the exploration and exploitation of tight oil and shale oil. | Kaiming Su Jungang Lu Huanxu Zhang Shijia Chen Yong Li Zhenglu Xiao Wen Qiu Meimei Han | 2020 | Geoscience Frontiers2020，11，6： | 1 |
| 13 | Accumulation of antioxidant phenolic constituents in submerged cultures of lnonotus obliquus显示文摘 | ZHENG Weifa ZHANG Meimei ZHAO Yanxia | 2009 | Bioresource Technology2009，100，： | 1 |
| 14 | Benign and highly efficient synthesis of indenoquinoline derivatives from 3-arylamino-5,5-dimethylcyclohex-2 enone,arylaldehyde and 1,3-indenedione in ionic liquid medium显示文摘 | Wang Xiangshan Zhang Meimei Zeng Zhaosen | 2008 | J Heterocyclic Chem2008，45，1： | 1 |
| 15 | Dynamic Changes of ORF1ab and N Gene Ct Values in COVID-19 Omicron Inpatients of Different Age Groups—Beijing Municipality,China,November-December 2022显示文摘Introduction:In November 2021,the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)Omicron variant was identified as the variant of concern and has since spread globally,replacing other cocirculating variants.To better understand the dynamic changes in viral load over time and the natural history of the virus infection,we analyzed the expression of the open reading frames 1ab(ORF1ab)and nucleocapsid(N)genes in patients infected with Omicron.Methods:We included patients initially admitted to the hospital for SARS-CoV-2 infection between November 5 and December 25,2022.We collected daily oropharyngeal swabs for quantitative reverse transcriptase-polymerase chain reaction tests using commercial kits.We depicted the cycle threshold(Ct)values for amplification of ORF1ab and N genes from individual patients in age-specific groups in a time series.Results:A total of 480 inpatients were included in the study,with a median age of 59 years(interquartile range,42 to 78;range,16 to 106).In the<45-year-old age group,the Ct values for ORF1ab and N gene amplification remained below 35 for 9.0 and 11.5 days,respectively.In the≥80-year-old age group,the Ct values for ORF1ab and N genes stayed below 35 for 11.5 and 15.0 days,respectively,which was the longest among all age groups.The Ct values for N gene amplification took longer to rise above 35 than those for ORF1ab gene amplification.Conclusion:The time to test negative varied among different age groups,with viral nucleic acid shedding taking longer in older age groups compared to younger age groups.As a result,the time to resolution of Omicron infection increased with increasing age. | Qing Zhang Zhaomin Feng Yiwei Hao Lirong Wei Aibin Wang Zhixing Han Meimei Tian Sheng Sun Xin'gang Li Tianjiao Xue Xiangjing Kong Baoliang Li Cheng Kou Quanyi Wang Da Huo Linghang Wang | 2023 | China CDC weekly2023，5，8： | 0 |
| 16 | An Efficient Method for the Synthesis of Indolo[3,2-c]quinoline Derivatives Catalyzed by Iodine显示文摘Schiff 底和吲哚的反应在直接存储器存取由碘催化,随后与 DDQ 对待,给了 indolo [3,2-c ] 在好收益的喹啉衍生物。3e 的结构被 X 光检查衍射分析证实。 | Yujing Zhou Meimei Zhang Mingyue Yin Xiangshan Wang | 2013 | Chinese Journal of Chemistry2013，31，2： | 0 |
| 17 | Polystyrene nanoplastics induce glycolipid metabolism disorder via NF-κB and MAPK signaling pathway in mice显示文摘Nanoplastics-induced developmental and reproductive toxicity,neurotoxicity and immunotoxicity are a focus of widespread attention.However,the effects of nanoplastics(NPs)on glycolipid metabolism and the precise underlying mechanisms are unclear at present.Here,we showed that oral administration of polystyrene nanoparticles(PS-NPs)disrupts glycolipid metabolism,with reactive oxygen species(ROS)identified as a potential key signaling molecule.After PS-NPs treatment,excessive production of ROS induced the infammatory response and activated the antioxidant pathway through nuclear factor-erythroid factor 2-related factor 2.The activation of nuclear factor-κB(NFκB)signaling pathway induced the phosphorylation of the mitogen-activated protein kinases(MAPK)signaling pathway,which induced the activation of extracellular regulated kinases(ERK)and p38.Constitutive activation of the MAPK signaling proteins induced high continued phosphorylation of insulin receptor substrate-1,in turn,leading to decreased protein kinase B(Akt)activity,which weakened the sensitivity of liver cells to insulin signals and induced insulin resistance.In parallel,phosphorylation of Akt led to loss of control of Fo XO1,a key gene of gluconeogenesis,activating transcription of glucose-6-phosphatase(G6PC)and phosphoenolpyruvate carboxykinase(PEPCK)in a manner dependent on PGC1α.Moreover,the activated ERK promoted lipid accumulation through ERK-PPARγcascades.Therefore,sterol regulatory element-binding protein-1 and levels of its downstream lipogenic enzymes,ACC-1,were up-regulated.Upon treatment with the antioxidant resveratrol,PS-NPs-induced glucose and lipid metabolic disorders were improved by inhibiting ROS-induced activation of NFκB and MAPK signaling pathway in mice.Based on above,PS-NPs exposure disrupts glycolipid metabolism in mice,with ROS identified as a potential key signaling molecule. | Xingpei Fan Xiaoyan Li Jiaxin Li Yuxia Zhang Xiangjuan Wei Hailong Hu Boya Zhang Haining Du Meimei Zhao Ruijiao Zhu Daqian Yang Yuri Oh Ning Gu | 2024 | Journal of Environmental Sciences2024，，3： | 0 |
| 18 | TMED10-mediated unconventional secretion of IL-33 regulates intestinal epithelium differentiation and homeostasis显示文摘Dear Editor,Unconventional protein secretion(UcPS)refers to the release of non-signal peptide-containing secretory proteins independent of the ER–Golgi trafficking.1 Although two major pathways including vesicle-dependent and-independent UcPS have been revealed,1 the physiological role of each pathway is largely unclear due to the lack of molecular details.Previously,we identified a translocation pathway termed transmembrane p24 trafficking protein 10(TMED10)-channeled UcPS(THU),which regulates vesicle-dependent UcPS pathway.2,3 In THU,TMED10 is a protein translocator key for mediating secretory cargo translocation into the ER–Golgi intermediate compartment to initiate vesicle-dependent UcPS. | Yang Wang Meimei Huang Xiangyue Mu Wanlu Song Qing Guo Min Zhang Yuan Liu Ye-Guang Chen Liang Ge | 2024 | Cell Research2024，34，3： | 0 |
| 19 | Glacial Lake Area Changes in High Mountain Asia during 1990-2020 Using Satellite Remote Sensing显示文摘Changes in a large-scale glacial lake area directly reflect the regional glacier status and climate changes.However,long time series of glacial lake dataset and comprehensive investigation of the spatiotemporal changes in the glacial lake area in the whole High Mountain Asia(HMA)region remained elusive. | Meimei Zhang Fang Chen Huadong Guo Lu Yi Jiangyuan Zeng Bin Li | 2023 | Research2023，，2： | 0 |
| 20 | Lutein-stevioside nanoparticle attenuates H_(2)O_(2)-induced oxidative damage in ARPE cells显示文摘In order to improve the bioavailability of lutein(LUT),a novel lutein-stevio side nanoparticle(LUT-STE)were prepared previously,but the information about LUT-STE on protecting of eye health was limited.This study investigated the effect of LUT-STE on antioxidant activity of H_(2)O_(2)-induced human retinal pigment epithelial(ARPE)cells.LUT and LUT-STE(final concentration of 5μg/mL)significantly enhanced cell viability from(74.84±5.10)%to(81.92±10.01)%(LUT)and(89.33±4.34)%(LUT-STE),and inhibited the cell apoptosis(P<0.05).After pretreatment with LUT-STE in ARPE cells,the levels of superoxide dismutase(SOD),catalase(CAT)and glutathion peroxidase(GSH-Px)in ARPE cells were significantly increased(P<0.05),the contents of reactive oxygen species(ROS)and malondialdehyde(MDA)were decreased.In addition,the vascular endothelial growth factor(VEGF)levels were inhibited by 13.61%and 17.39%,respectively,pretreatment with LUT and LUT-STE.Western blotting results showed that the pretreatment with LUT-STE inhibited the expression of caspase-9 and caspase-3 and up-regulated Bcl-2/Bax pathway to inhibit H_(2)O_(2)-induced apoptosis.In summary,the novel delivery LUT-STE had more pronounced inhibitory effect on H_(2)O_(2)-induced damage in human ARPE cells. | Zhuqing Dai Meimei Nie Ye Chen Jiangfeng Song Yayuan Xu Zhongyuan Zhang Guodong Zhang Shumo Yan Xing Zhang Dajing Li | 2024 | Food Science and Human Wellness2024，13，3： | 0 |
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