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| 1 | Genome architecture and tetrasomic inheritance of autotetraploid potato显示文摘Potato(Solanum tuberosum)is the most consumed non-cereal food crop.Most commercial potato cultivars are autotetraploids with highly heterozygous genomes,severely hampering genetic analyses and improvement.By leveraging the state-of-the-art sequencing technologies and polyploid graph binning,we achieved a chromosome-scale,haplotype-resolved genome assembly of a cultivated potato,Cooperation-88(C88).lntra-haplotype comparative analyses revealed extensive sequence and expression differences in this tetraploid genome.We identified haplotype-specific pericentromeres on chromosomes,suggesting a distinct evolutionary trajectory of potato homologous centromeres.Furthermore,we detected double reduction events that are unevenly distributed on haplotypes in 1021 of 1034 selfing progeny,a feature of autopolyploid inheritance.By distinguishing maternal and paternal haplotype sets in C88,we simulated the origin of heterosis in cultivated tetraploid with a survey of 3110 tetra-allelic loci with deleterious mutations,which were masked in the heterozygous condition bytwo parents.This study provides insights into the genomic architecture of autopolyploids and will guide their breeding. | Zhigui Bao Canhui Li Guangcun Li Pei Wang Zhen Peng Lin Cheng Hongbo Li Zhiyang Zhang Yuying Li Wu Huang Mingwang Ye Daofeng Dong Zhukuan Cheng Peter VanderZaag Evert Jacobsen Christian W.B.Bachem Suomeng Dong Chunzhi Zhang Sanwen Huang Qian Zhou | 2022 | Molecular Plant2022，15，7： | 4 |
| 2 | Design of SERS nanoprobes for Raman imaging:materials, critical factors and architectures显示文摘Raman imaging yields high specificity and sensitivity when compared to other imaging modalities, mainly due to its fingerprint signature. However, intrinsic Raman signals are weak, thus limiting medical applications of Raman imaging. By adsorbing Raman molecules onto specific nanostructures such as noble metals, Raman signals can be significantly enhanced, termed surfaceenhanced Raman scattering(SERS). Recent years have witnessed great interest in the development of SERS nanoprobes for Raman imaging. Rationally designed SERS nanoprobes have greatly enhanced Raman signals by several orders of magnitude, thus showing great potential for biomedical applications.In this review we elaborate on recent progress in design strategies with emphasis on material properties,modifying factors, and structural parameters. | Mingwang Li Yuanyuan Qiu Chenchen Fan Kai Cui Yongming Zhang Zeyu Xiao | 2018 | Acta Pharmaceutica Sinica B2018，8，3： | 3 |
| 3 | Effect of amino acid mutation at position 127 in 3A of a rabbitattenuated foot-and-mouth disease virus serotype Asia1 on viral replication and infection显示文摘An amino acid mutation(R127→I) in the 3A non-structural protein of an FMDV serotype Asia1 rabbit-attenuated ZB strain was previously found after attenuation of the virus. To explore the effects of this mutation on viral replication and infection, the amino acid residue isoleucine(I) was changed to arginine(R) in the infectious cDNA clone of the rabbit-attenuated ZB strain by sitedirected mutagenesis, and the R127-mutated virus was rescued. BHK monolayer cells and suckling mice were inoculated with the R127-mutated virus to test its growth property and pathogenicity, respectively. The effects of the R127 mutation on viral replication and virulence were analyzed. The data showed that there was a slight difference in plaque morphology between the R127-mutated and wild-type viruses. The growth rate of the mutated virus was lower in BHK-21 cells and its virulence in suckling mice was also attenuated. This study indicates that the R127 mutation in 3A may play an important role in FMDV replication in vitro and in pathogenicity in suckling mice. | Aiguo Xin Mingwang Zhu Qi Hu Haisheng Miao Zhenqi Peng Yuwen He Lin Gao Huachun Li | 2014 | Virologica Sinica2014，29，5： | 2 |
| 4 | In-situ transient photovoltage study on interface electron transfer regulation of carbon dots/NiCo_(2)O_(4) photocatalyst for the enhanced overall water splitting activity显示文摘Photocatalytic hydrogen production by overall water solar-splitting is a prospective strategy to solve energy crisis.However,the rapid recombination of photogenerated electron–hole pairs deeply restricts photocatalytic activity of catalysts.Here,the in-situ transient photovoltage(TPV)technique was developed to investigate the interfacial photogenerated carrier extraction,photogenerated carrier recombination and the interfacial electron delivery kinetics of the photocatalyst.The carbon dots/NiCo_(2)O_(4)(CDs/NiCo_(2)O_(4))composite shows weakened recombination rate of photogenerated carriers due to charge storage of CDs,which enhances the photocatalytic water decomposition activity without any scavenger.CDs can accelerate the interface electron extraction about 0.09 ms,while the maximum electron storage time by CDs is up to 0.7 ms.The optimal CDs/NiCo_(2)O_(4)composite(5 wt.%CDs)displays the hydrogen production of 62µmol·h^(−1)·g^(−1) and oxygen production of 29µmol·h^(−1)·g^(−1) at normal atmosphere,which is about 4 times greater than that of pristine NiCo_(2)O_(4).This work provides sufficient evidence on the charge storage of CDs and the interfacial charge kinetics of photocatalysts on the basis of in-situ TPV tests. | Haodong Nie Yan Liu Yi Li Kaiqiang Wei Zhenyu Wu Hong Shi Hui Huang Yang Liu Mingwang Shao Zhenhui Kang | 2022 | Nano Research2022，15，3： | 2 |
| 5 | Interior-Point Algorithm for Linear Optimization Based on a New Kernel Function显示文摘In this paper, we design a primal-dual interior-point algorithm for linear optimization. Search directions and proximity function are proposed based on a new kernel function which includes neither growth term nor barrier term. Iteration bounds both for large-and small-update methods are derived, namely, and . This new kernel function has simple algebraic expression and the proximity function has not been used before. Analogous to the classical logarithmic kernel function, our complexity analysis is easier than the other primal-dual interior-point methods based on logarithmic barrier functions and recent kernel functions. | CHEN Donghai ZHANG Mingwang LI Weihua | 2012 | Wuhan University Journal of Natural Sciences2012，17，1： | 2 |
| 6 | Thermomechanical coupling simulation and experimental study in the isothermal ECAP processing of Ti-6Al-4V alloy显示文摘The thermomechanical coupling simulation of the isothermal equal channel angular pressing(ECAP) of Ti-6Al-4V alloy was conducted.The effect of processing parameters,ECAP pass number and the residual billet on the effective strain,stress and temperature distribution was investigated.Based on the coupling simulation results,it is found that the shear factor,ram speed,deformation temperature,channel intersection angle and residual billet significantly affect the ECAP deformation behaviors.Meanwhile,the experimental study of the isothermal ECAP process of Ti-6Al-4V alloy using route C,in which the repeated rotation angle around the longitudinal billet axis before reinsertion in the die was 180°,were conducted at a deformation temperature of 750°C,a ram speed of 0.3 mm·s-1,an outer arc of curvature of 60° and a channel intersection angle of 120°.Furthermore,a large amount of recrystallization occurs and some prior α phase grains grow in the post-ECAP process of Ti-6Al-4V alloy.The yield strength of post-ECAP Ti-6Al-4V alloy increases compared with that of as-received Ti-6Al-4V alloy. | LI Miaoquan ZHANG Chen LUO Jiao FU Mingwang | 2010 | Rare Metals2010，29，6： | 2 |
| 7 | Melatonin improves the survival of cryopreserved callus of Rhodiola crenulata显示文摘 | YanZhao Li‐WangQi Wei‐MingWang Praveen K.Saxena Chun‐ZhaoLiu | 2010 | Journal of Pineal Research2010，，1： | 1 |
| 8 | Morphology and Properties of PVC/Clay Nanocomposites via in SituEmulsion Polymerization显示文摘 | Pan Mingwang Shi Xudong Li Xiucuo | 2004 | Journal of Applied Polymer Science2004，94，： | 1 |
| 9 | Morphology and properties of PVC/clay nanocomposites via in situ emulsion polymerization显示文摘 | Xudong Shi Xiucuo Li | 2004 | Journal of Applied Polymcr Science2004，94，： | 1 |
| 10 | Microwave-assisted synthesis of tube-like HgS nanoparticles in aqueous solution under ambient condition显示文摘 | Mingwang Shao Lingfen Kong Qing Li Weichao Yu Yitai Qian | 2003 | Inorganic Chemistry Communications2003，，： | 1 |
| 11 | Morphology and properties of PVC/clay nanocomposites via in-situ emulsion polymerization显示文摘 | PAN Mingwang SHI Xudong LI Xiucuo | 2004 | Journal of Applied Polymer Science2004，94，1： | 1 |
| 12 | A trajectory planning method on error compensation of residual height for aero-engine blades of robotic belt grinding显示文摘While the traditional trajectory planning methods are used in robotic belt grinding of blades with an uneven machining allowance distribution, it is hard to obtain the preferable profile accuracy and surface quality to meet the high-performance requirements of aero-engine. To solve this problem, a novel trajectory planning method is proposed in this paper by considering the developed interpolation algorithm and the machining allowance threshold. The residual height error obtained from grinding experiments of titanium alloy sample was compensated to modify the calculation model of row spacing, and a new geometric algorithm was presented to dynamically calculate the cutter contact points based on this revised calculation model and the dichotomy method. Subsequently, the off-line machining program is generated based on a double-vector controlling method to obtain an optimal contact posture. On this basis, three sets of robotic grinding tests of titanium alloy blades were conducted to investigate the advantages of the proposed method.The comparative experimental results revealed that the presented algorithm had improved the surface profile accuracy of blade by 34.2% and 55.1%, respectively. Moreover, the average machined surface roughness was achieved to 0.3 μm and the machining efficiency was obviously promoted. It is concluded that this research work is beneficial to comprehensively improve the machined quality of blades in robotic belt grinding. | Chong LV Lai ZOU Yun HUANG Xifan LIU Zhaorui LI Mingwang GONG Heng LI | 2022 | Chinese Journal of Aeronautics2022，35，4： | 1 |
| 13 | hsa_circ_0056856 in the serum serves as a potential novel biomarker for disease activity in psoriasis显示文摘To the Editor:Psoriasis is a chronic immune-related inflammatory skin disease.The clinical severity of psoriasis varies greatly,and recurrence occurs frequently.[1]Many attempts have been made to identify biomarkers for psoriasis;however,there are currently no specific markers that can accurately monitor disease severity and treatment efficacy.Circular RNAs(circRNAs)are a novel class of endogenous noncoding RNAs that are highly stable and resistant to RNase R since they can form covalently closed loops without 50 caps and 30 tails.[2]It has been reported that circRNAs could exist in body fluids,such as serum and plasma,and could serve as molecular biomarkers in the diagnosis and prognosis of several diseases.[3]In this study,we detected the alteration of circRNAs and investigated the potential value of hsa_circ_0056856 as a biomarker for disease severity in serum samples from psoriasis patients and healthy controls(HCs). | Mingwang Zhang Minna Han Jian Li Kang Tao Xin Yang Haihao Zheng Rongya Yang Zhifang Zhai | 2022 | Chinese Medical Journal2022，，14： | 1 |
| 14 | Spatial approximate string search显示文摘 | Feifei Li Bin Yao Mingwang Tang | 2013 | TKDE2013，25，6： | 1 |
| 15 | Morphology and Properties of PVC/Clay Nanocomposites via in Situ Emulsion Polymerization显示文摘 | Mingwang Pan Xudong Shi Xiucuo Li | 2004 | Journal of Applied Polymer Science2004，，94： | 1 |
| 16 | Estimating the time interval between transmission generations and the presymptomatic period by contact tracing surveillance data from 31 provinces in the mainland of China显示文摘The global pandemic of 2019 coronavirus disease(COVID-19)is a great assault to public health.Presymptomatic transmission cannot be controlled with measures designed for symptomatic persons,such as isolation.This study aimed to estimate the interval of the transmission generation(TG)and the presymptomatic period of COVID-19,and compare the ftting effects of TG and serial interval(S)based on the SEIHR model incorporating the surveillance data of 3453 cases in 31 provinces.These data were allocated into three distributions and the value of AIC presented that the Weibull distribution fitted well.The mean of TG was 5.2 days(95%C:4.6-5.8).The mean of the presymptomatic period was 2.4 days(95%CI:1.5-3.2).The dynamic model using TG as the generation time performed well.Eight provinces exhibited a basic reproduction number from 2.16 to 3.14.Measures should be taken to control presymptomatic transmission in the COVID-19 pandemic. | Zhongxing Ding Kai Wang Mingwang Shen Kai Wang Shi Zhao Wenyu Song Rui Li Zhongjie Li Liping Wang Ganzhu Feng Zhiliang Hu Hongxia Wei Yanni Xiao Changjun Bao Jianli Hu Liguo Zhu Yong Li Xufeng Chen Yi Yin Weiming Wang Yongli Cai Zhihang Peng Hongbing Shen | 2021 | Fundamental Research2021，1，2： | 1 |
| 17 | Mass testing—An underexplored strategy for COVID-19 control显示文摘Mass testing is an intervention strategy for COVID-19 control in the general population regardless of the presentation of symptoms.It involves collecting nasal or pharyngeal swabs for DNA testing,often using the polymerase chain reaction method.Countries that have used mass testing consider it to be a viable strategy to control the COVID-19 pandemic as the strategy can potentially identify and isolate asymptomatic cases in the early stages of infection and reduce the risk of virus transmission.Since the reopening of Wuhan,China,in early April 2020,China has conducted mass testings in three megacities with populations of over 10 million,including Beijing and Qingdao1 at the beginning of their local outbreaks,and Wuhan immediately after the reopening. | Mingwang Shen Yanni Xiao Guihua Zhuang Yan Li Lei Zhang | 2021 | The Innovation2021，2，2： | 0 |
| 18 | Carbon dots/Bi_(2)WO_(6) composite with compensatory photo-electronic effect for overall water photo-splitting at normal pressure显示文摘Overall water photo-splitting is a prospective ideal pathway to produce ultra-clean H_(2) energy by semiconductors.However,the band structure of many semiconductors cannot satisfy the requirement of H_(2) and O_(2) production at the same time.Herein,we illustrate that carbon dots(CDs)/Bi_(2)WO_(6) photocatalyst with compensatory photo-electronic effect has enhanced activity for overall water photo-splitting without any sacrificial agent.In this complex photocatalytic system,the photo-potential provided by CDs makes the CDs/Bi2WO6(C-BWO)composite could satisfy the band structure conditions for overall water photo-splitting.The C-BWO composite(3 wt%CDs content)exhibits optimized hydrogen evolution(oxygen evolution)of 0.28μmol/h(0.12μmol/h)with an approximate 2:1(H_(2):O_(2))stoichiometry at normal pressure.We further employed the in-situ transient photovoltage(TPV)technique to study the photoelectron extraction and the interface charge transfer kinetics of this composite catalyst. | Haodong Nie Kaiqiang Wei Yi Li Yan Liu Yajie Zhao Hui Huang Mingwang Shao Yang Liu Zhenhui Kang | 2021 | Chinese Chemical Letters2021，32，7： | 0 |
| 19 | Metal atom doping-induced S-scheme heterojunction boosts the photoelectric response显示文摘Carrier migration path and driving forces are two crucial factors for charge separation of heterojunction with efficient photoelectric response from the thermodynamic and kinetic perspectives,respectively.Constructing the S-scheme heterojunction and achieving an efficient migration path for space charge separation have aroused great interest,while a thorough insight into tuning interfacial band bending for S-scheme heterojunction is absent.Herein,we report a class of Zn atom-doped CeO_(2)/g-C_(3)N_(4) heterostructure for achieving a new carrier migration path conversion from inferior type-II to advanced S-scheme.Zn-dependent volcano-type plot for Zn-CeO_(2) is established to tune the Fermi level of CeO_(2).The built-in electric field for carrier flow dynamics strengthens when coupling with g-C_(3)N_(4),which significantly boosts the photoelectric response.Based on the intrinsic enzymelike activity of Zn-CeO_(2),we further demonstrate that the Zn-CeO_(2)/g-C_(3)N_(4) S-scheme heterojunction can be explored for constructing a sensitive nanozymatic photoelectrochemical biosensor for the detection of acetylcholinesterase. | Mingwang Liu Jing Wen Ying Qin Jinli Li Yinjun Tang Lei Jiao Yu Wu Qie Fang Lirong Zheng Xiaowen Cui Wenling Gu Chengzhou Zhu Liuyong Hu Shaojun Guo | 2023 | Science China Chemistry2023，66，4： | 0 |
| 20 | A Mehrotra-Type Predictor-Corrector Algorithm for P_*(κ) Linear Complementarity Problems显示文摘Mehrotra-type predictor-corrector algorithm,as one of most efficient interior point methods,has become the backbones of most optimization packages.Salahi et al.proposed a cut strategy based algorithm for linear optimization that enjoyed polynomial complexity and maintained its efficiency in practice.We extend their algorithm to P_*(κ)linear complementarity problems.The way of choosing corrector direction for our algorithm is different from theirs. The new algorithm has been proved to have an ο((1+4κ)(17+19κ) √(1+2κn)^(3/2)log[(x^0)~Ts^0/ε] worst case iteration complexity bound.An numerical experiment verifies the feasibility of the new algorithm. | Weihua LI Mingwang ZHANG Yiyuan ZHOU | 2012 | Journal of Mathematical Research with Applications2012，32，3： | 0 |
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