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| 1 | Newborn screening with targeted sequencing:a multicenter investigation and a pilot clinical study in China显示文摘Different newborn screening(NBS) programs have been practiced in many countries since the 1960 s. It is of considerable interest whether next-generation sequencing is applicable in NBS. We have developed a panel of 465 causative genes for 596 early-onset, relatively high incidence, and potentially actionable severe inherited diseases in our Newborn Screening with Targeted Sequencing(NESTS) program to screen 11,484 babies in 8 Women and Children’s hospitals nationwide in China retrospectively. The positive rate from preliminary screening of NESTS was 7.85%(902/11,484). With 45.89%(414/902) follow-up of preliminary positive cases, the overall clinically confirmative diagnosis rate of monogenic disorders was 12.07%(50/414), estimating an average of 0.95%(7.85% × 12.07%) clinical diagnosis rate, suggesting that monogenic disorders account for a considerable proportion of birth defects. The disease/gene spectrum varied in different regions of China. NESTS was implemented in a hospital by screening 3923 newborns to evaluate its clinical application. The turn-around time of a primary report, including the sequencing period of < 7 days, was within 11 days by our automatic interpretation pipeline. Our results suggest that NESTS is feasible and cost-effective as a first-tier NBS program, which will change the status of current clinical practice of NBS in China. | Chanjuan Hao Ruolan Guo Xuyun Hu Zhan Qi Qi Guo Xuanshi Liu Yuanhu Liu Yanhua Sun Xiaofen Zhang Feng Jin Xiujie Wu Ren Cai Dingyuan Zeng Xijiang Hu Xiaohua Wang Xiaoping Ji Wenjie Li Quansheng Xing Lanfang Mu Xiulian Jiang Xue Yang Weimin Yang Yan Zhang Qianli Yin Xin Ni Wei Li | 2022 | Journal of Genetics and Genomics2022，49，1： | 7 |
| 2 | Radio-Acoustic Integrated Network for Ocean Information Transmission:Framework and Enabling Technologies显示文摘An important vision of next generation mobile system is to provide global internet access.The Space-Terrestrial Integrated Network(STIN)has been proposed and intensively studied to tackle this challenge.Due to the severe attenuation of radio signals in water,the STIN cannot be directly applied in underwater scenarios.In this paper we envision a framework of integrated radio-acoustic network arming at high-efficient data transmission in underwater scenarios,where acoustic signal is for underwater communication and radio signal is for surface and air communications.Since radio links have much higher data transmission rate and lower delay,in the integrated radio-acoustic network,the acoustic links easily become congested,at the same time the radio links are not fully utilized.We therefore propose that the integrated radio-acoustic network should be properly designed to minimize the hop count of acoustic links,as well as the signaling overhead in the acoustic subnetwork.We then present a novel network framework and the relative technologies to help moving the signaling overhead to the radio subnetwork. | Fangjiong Chen Zilong Jiang Fei Ji Hua Yu Quansheng Guan Feng Liu | 2021 | China Communications2021，18，9： | 4 |
| 3 | Hydrochemical Dynamic Characteristics and Evolution of Underground Brine in the Mahai Salt Lake of the Qaidam Basin Qinghai-Tibet Plateau显示文摘The mineral rock salts present in the Mahai Salt Lake of the Qaidam basin exhibit high solubilities in water. In addition, the multicomponent underground brine exhibits a high salinity and is easily precipitated. In the natural state, brine transport in the brine layer is extremely slow, and the brine is in a relatively stable chemical equilibrium state with the rock salt media. However, during mining, both the seepage and the chemical fields fluctuate significantly, thereby disrupting the equilibrium and leading to variations in the chemical composition and dynamic characteristics of the brine. Therefore, we selected underground brine from the Mahai Salt Lake, collecting a total of 183 brine samples over three stages of mining(i.e., the early stage of underground brine extraction, the initial stage of mining, and the later stage of mining). Using a range of analytical techniques, the chemical dynamics of the underground brine water and its evolution were systematically studied. We found that evaporation and enrichment were the main mechanisms of underground brine evolution in the Mahai Salt Lake, with cation exchange and mineral dissolution/precipitation being key factors in determining the dynamic characteristics and evolution of the brine. | HU Shuya ZHAO Quansheng WANG Guangcai ZHANG Jianwei FENG Juan | 2018 | Acta Geologica Sinica(English Edition)2018，92，5： | 4 |
| 4 | Evaluation of the immunomodulatory effects of anti-COVID-19 TCM formulae by multiple virus-related pathways显示文摘Dear Editor,The coronavirus infectious disease 2019(COVID-19)outbreak is seriously endangering human health.Most patients with severe COVID-19 are characterized by sustained cytokine production and hyper-inflammation,which is known as cytokine storm syndrome.1-3 Elaborating the anti-inflammatory response is crucial to these patients,and interieukin-6(IL6)inhibitors and steroids have been recommended in clinical practice.1 However,after the cytokine storm phase,the host immune response to sepsis may develop into a protracted immunosuppressive phase. | Liansheng Qiao Wenting Huang Xiaoling Zhang Hongyan Guo Dong Wang Quansheng Feng Ronghua Jin Lan Xie Weimin Li Jing Cheng | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 4 |
| 5 | Minimally invasive perventricular device closure of perimembranous ventricular septal defect without cardiopulmonary bypass: Multicenter experience and mid-term follow-up显示文摘 | Quansheng Xing Silin Pan Qi An Zewei Zhang Jianhua Li Feng Li Qin Wu Zhongyun Zhuang | 2010 | The Journal of Thoracic and Cardiovascular Surgery2010，，6： | 2 |
| 6 | Porosity Distribution Characteristics and Geological Analysis of Brine Storage Medium in the Qaidam Basin, Western China显示文摘Underground brine is an unusual water resource that contains abundant mineral resources. It is distributed widely in the Qaidam Basin, western China, a hyperarid inland basin located in the northern Tibetan Plateau. Pores in the brine storage medium act as storage space and transmission channels of underground brine. Therefore, the porosity of brine storage medium determines its ability to store brine. In this study, Mahai Salt Lake was used as the research area as a modern saline lake located in the north area of the Qaidam Basin. A total of 100 porosity samples were collected from eight sampling points in two profiles of the research area at sampling depths of 1.30–314.78 m. The porosity distribution characteristics and influencing factors in brine storage medium were analysed according to the measured porosity data. Based on analysis of the pore structure characteristics, the brine storage medium contains intercrystalline pores, unlike conventional freshwater storage mediums. Moreover, the primary salt rock is susceptible to dissolution by lighter brine, facilitating the formation of secondary porosity. Due to the formation of secondary pores, a porosity greater than 20% remains even at buried depths greater than 100 m. Based on the geological statistical analysis, due to the geographic location, salt formation time, and depositional environment, the porosity values of Mahai Salt Lake do not exhibit a wider distribution, but also show more extreme values than a nearby salt lake. Based on the porosity characteristics by depth, due to the presence of secondary pores, flooding, stratigraphic static pressure, and other factors, porosity shows fluctuations with increasing depth. | HU Shuya XIAO Changlai LIANG Xiujuan ZHAO Quansheng WANG Guangcai ZHANG Jianwei FENG Juan | 2018 | Chinese Geographical Science2018，28，4： | 2 |
| 7 | Effects of Guangxi Hepu Pearl Hydrolysate on Proliferation Activity and Apoptosis of Human Hepatic Stellate Cells显示文摘[Objective] The paper was to observe the effects of Guangxi Hepu pearl hydrolysate on proliferation and apoptosis of human hepatic stellate cells. [Method] The inhibition rate against the proliferation of human hepatic stellate cells was determined by MTT colorimetry after co-incubation with pearl hydrolysate for 48 h. The percentage of early and late apoptotic cells was determined by flow cytometry(Annexin V-FITC/PI staining). [Result] Low, medium and high concentrations of pearl hydrolysate could inhibit the proliferation of human hepatic stellate cells, and the inhibition rates at 48 h were 12.4%, 27.4% and 37.8%, respectively. The low, medium and high concentrations of pearl hydrolysate could induce the apoptosis of cells. The percentages of total apoptotic cells(early apoptotic + late apoptotic) at 48 h were 8.97%, 16.09% and 26.98%, respec-tively. [Conclusion] Pearl hydrolysate can inhibit the proliferation of human hepatic stellate cells and induce the apoptosis of these cells, which may be the mechanism of anti-hepatic fibrosis effect of pearl hydrolysate. These effects are dose-dependent. It is also found that the above cellular effects of high dose pearl hydrolysate are stronger than those of colchicine and compound Biejiaruangan tablets. | Yue Peng Quansheng Feng Jiang Lin Tiejian Zhao Peng Liu Yanhui Cen | 2021 | Plant Diseases and Pests2021，12，3： | 1 |
| 8 | Intelligent dimensioning for mechanical parts based on feature extraction显示文摘 | ZHANG Kechen FENG Xinan LU Quansheng | 2004 | Computer-Aided Deaisn2004，33，： | 1 |
| 9 | Thermoviscosifying polymer used for enhanced oil recovery: rheological behaviors and core flooding test显示文摘 | Quansheng Chen Yu Wang Zhiyong Lu Yujun Feng | 2013 | Polymer Bulletin2013，，2： | 1 |
| 10 | Melt Blending of Polypropylene-Blend- Polyamide 6-Blend-Organoclay Systems 显示文摘 | Quansheng Su Meng Feng Shimin Zhang | 2007 | Polymer International2007，56，1： | 1 |
| 11 | The impacts of oxytetracycline on humification during manure composting can be alleviated by adjusting initial moisture contents as illustrated by NMR显示文摘Oxytetracycline(OTC)residues have been found in soil and water,and they may pose potential risks to agricultural ecological environments.One of the most impactful ways for OTC to enter the soil and water environments is through excrement used as organic fertilizer.Therefore,it is important to remove OTC during manure composting and to understand the transformation of the organic materials during composting in the presence of OTC.In the present paper,chicken manure and wheat sawdust spiked with OTC were composted under different initial moisture contents(MC)to evaluate the degradation of OTC and changes of organic matter during the composting process.The MC has a significant effect on OTC degradation during composting.A higher MC of 65% was more conducive to OTC degradation(77.4%)and compost maturity compared to the lower MC.However,the higher MC of 65%could increase the ammonia volatilization by promoting nitrification compared to the lower MC.An increase in the initial MC could improve the composting temperature.NMR results illustrated that the presence of OTC could affect the internal transformation of aliphatics,and OTC inhibited compost humification.Thus,an initial MC of 55–65% can alleviate the impacts of OTC on humification during manure composting. | FENG Yao WANG Gui-zhen LIU Yuan-wang CHENG Deng-miao FAN Shuang-hu ZHAO Quansheng Jianming XUE ZHANG Shu-qing LI Zhao-jun | 2021 | Journal of Integrative Agriculture2021，20，8： | 1 |
| 12 | Application of multi - linear regress analysis to predict Beijing urban domestic water demand 显示文摘 | Zhang Yajun Liu Quansheng Feng Cuimin | 2003 | Water & Waste Water2003，29，4： | 1 |
| 13 | Synthesis and surface activities of amidobetaine surfactants with ultra-long unsaturated hydrophobic chains显示文摘 | Feng Dan Zhang Yongmin Chen Quansheng | | 0，，5： | 1 |
| 14 | Intelligent location- dimensioning of cylindrical surfaces in mechanical parts 显示文摘 | Chen Kezhang Feng Xinan Lu Quansheng | 2002 | Computer-Aided Design2002，34，3： | 1 |
| 15 | Robust model for tunnel squeezing using Bayesian optimized classifiers with partially missing database显示文摘Accurately predicting and estimating the squeezing and ground response to tunneling remains challenging.Moreover,tunnel-squeezing hazards are much more likely to occur in deeply buried long tunnels with complex engineering-geological environments.There-fore,a high-performance predictive model for tunnel squeezing is necessary.A superior ensemble classifier is put forward in this study,which is composed of four individual classifiers(gradient boosting classifier,extra-trees classifier,AdaBoost classifier,and Logistic regression classifier)and two optimization algorithms(Bayesian optimization(BO)and sparrow search algorithm(SSA)).The training database covers five parameters:tunnel depth(H),rock tunneling quality index(Q),tunnel diameter(D),support stiffness(K),and strength stress ratio(SSR),about which the basic information is accessible at the early design phases.However,the dataset compiled from the literature is insufficient.Thus,the ten proposed methods are used to replace the missing values.During the model training pro-cess,BO shows its strong ability to optimize seventeen hyperparameters.When applied to tune the classifiers’weights,SSA achieves a fast and efficient performance.The novel Shapley Additive Explanations–LightGBM method indicates that the K is the most important input feature,followed by SSR,Q,H,and D,respectively.The ensemble classifier is then validated using the test set and additional his-torical case projects.The validation shows that the model can achieve an accuracy of 98%(i.e.,the error rate is 2%)on the test set,higher than those achieved by previous prediction models.Moreover,the predicted probability could provide warning information for timely support measures.Finally,the application results are illustrated through tests on the tunnel sections that have not yet been excavated in the line of the Sichuan–Tibet railway project.The applied predictive tendencies and laws are in line with the practical experience.In sum-mary,the proposed model’s prediction results are reasonable,and its prediction will be more accurate as more data is collected and trained for prewarning the tunnel squeezing hazard. | Yin Bo Xing Huang Yucong Pan Yanfang Feng Penghai Deng Feng Gao Ping Liu Quansheng Liu | 2023 | Underground Space2023，，3： | 0 |
| 16 | Genome and epigenome editing identify CCR9 and SLC6A20 as target genes at the 3p21.31 locus associated with severe COVID-19显示文摘Dear Editor,The coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is a major global health threat.Mortality is predominantly caused by severe respiratory failure related to interstitial pneumonia in both lungs and acute respiratory distress syndrome.Recently,genome-wide association studies(GWASs)have identified chromosome 3p21.31(sentinel variant:rsl 1385942)to be associated with both severe and general affected COVID-19 cases. | Yao Yao Fei Ye Kailong Li Peng Xu Wenjie Tan Quansheng Feng Shuquan Rao | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 0 |
| 17 | Compressive strength prediction of sprayed concrete lining in tunnel engineering using hybrid machine learning techniques显示文摘Sprayed concrete lining is a commonly employed support measure in tunnel engineering,which plays an important role in construction safety.Compressive strength is a key performance indicator of sprayed concrete lining,and the traditional measuring method is time-consuming and laborious.This paper proposes various hybrid machine learning algorithms to accomplish the advanced prediction of compressive strength of sprayed concrete lining based on the mixture design.Two hundred and five sets of experimental data were collected from a water conveyance tunnel in northwestern China for model construction,and each set of data was made up of six basic input variables(i.e.,water,cement,mineral powder,superplasticizer,coarse aggregate,and fine aggregate)and one output variable(i.e.,compressive strength).In order to eliminate the correlation between input variables,a new composite indicator(i.e.,the water-binder ratio)was introduced to achieve dimensionality reduction.After that,four hybrid models in total were built,namely BPNN-QPSO,SVR-QPSO,ELM-QPSO,and RF-QPSO,where the hyper-parameters of BPNN,SVR,ELM,and RF were auto-tuned by QPSO.Engineering application results indicated that RF-QPSO achieved the lowest mean absolute percentage error(MAPE)of 3.47% and root mean square error(RMSE)of 1.30 and the highest determination coefficient(R^(2))of 0.93 in the four hybrid models.Moreover,RFQPSO had the shortest running time of 0.15 s,followed by SVR-QPSO(0.18 s),ELM-QPSO(1.19 s),and BPNN-QPSO(1.58 s).Compared with BPNN-QPSO,SVR-QPSO,and ELM-QPSO,RF-QPSO performed the most superior performance in terms of both prediction accuracy and running speed.Finally,the importance of input variables on the model performance was quantitatively evaluated,further enhancing the interpretability of RF-QPSO. | Xin Yin Feng Gao Jian Wu Xing Huang Yucong Pan Quansheng Liu | 2022 | Underground Space2022，7，5： | 0 |
| 18 | Expert Consensus on Nutritional Support for Children with Congenital Heart Disease(2023 Edition)显示文摘The second edition of the expert consensus on pediatric nutrition was formed based on a global update of pedia-tric nutrition guidelines or consensus worldwide,the management of congenital heart disease,and the results of multi-center clinical nutrition research for congenital heart disease following thefirst Chinese consensus edition of 2016.The consensus was also shaped by the results of three discussion sessions and two questionnaires con-ducted by the 13-member collaboration group.This process was informed by both clinical guidelines and expert consensus.The quality of literature,both in English and Chinese,and the level of recommendations were evaluated using the Grading of Recommendations Assessment,Development,and Evaluations(GRADE)system. | Xuming Mo Wei Cai Jirong Qi Zhuoming Xu Ying Wang Weihui Yan Shoujun Li Nianguo Dong Xinxin Chen Jinfen Liu Qiang Shu Jimei Chen Haibo Zhang Hao Zhang Quansheng Xing Qi An Xiaofeng Li Xu Wang Yan He Junwu Su Taibing Fan Teng Ming Weibing Tang Li Hong Jinghao Zheng Ming Ye Guocheng Sun Yiqun Ding Liang Tao Yifeng Yang Zhongshi Wu Hua Cao Qiang Wang Keming Yang Libing Zhang Ping Wen Yanqin Cui Bo Zhai Yong Zou Qingya Tang Rui Chen Chun Wu Zhiyu Feng Caixia Liu Yaping Mi Rufang Zhang Ke Lin Xin Li Mingan Pi Xiangming Fan Shanshan Shi Peng Huang Zhengxia Pan Jiafeng Qi Renwei Chen Shuguang Tao Yaqin Shu Huifeng Zhang Lan Jiang Min Da Nishant Patel Liang Hu Cardiac Surgery Group of Pediatric Surgery Society of Chinese Medical Association and Parenteral Enteral Nutrition Society of Chinese Medical Association | 2023 | Congenital Heart Disease2023，18，6： | 0 |
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