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| 1 | m^6A-dependent biogenesis of circular RNAs in male germ cells显示文摘The majority of circular RNAs(circRNAs)spliced from coding genes contain open reading frames(ORFs)and thus,have protein coding potential.However,it remains unknown what regulates the biogenesis of these ORF-containing circRNAs,whether they are actually translated into proteins and what functions they play in specific physiological contexts.Here,we report that a large number of circRNAs are synthesized with increasing abundance when late pachytene spermatocytes develop into round and then elongating spermatids during murine spermatogenesis.For a subset of circRNAs,the back splicing appears to occur mostly at m^6A-enriched sites,which are usually located around the start and stop codons in linear mRNAs.Consequently,approximately a half of these male germ cell circRNAs contain large ORFs with m^6A-modified start codons in their junctions,features that have been recently shown to be associated with protein-coding potential.Hundreds of peptides encoded by the junction sequences of these circRNAs were detected using liquid chromatography coupled with mass spectrometry,suggesting that these circRNAs can indeed be translated into proteins in both developing(spermatocytes and spermatids)and mature(spermatozoa)male germ cells.The present study discovered not only a novel role of m^6A in the biogenesis of coding circRNAs,but also a potential mechanism to ensure stable and long-lasting protein production in the absence of linear mRNAs,i.e.,through production of circRNAs containing large ORFs and m^6A-modified start codons in junction sequences. | Chong Tang Yeming Xie Tian Yu Na Liu Zhuqing Wang Rebekah J.Woolsey Yunge Tang Xinzong Zhang Weibing Qin Ying Zhang Ge Song Weiwei Zheng Juan Wang Weitian Chen Xiongyi Wei Zhe Xie Rachel Klukovich Huili Zheng David R.Quilici Wei Yan | 2020 | Cell Research2020，30，3： | 12 |
| 2 | Bridge Continuous Deformation Measurement Technology Based on Fiber Optic Gyro显示文摘桥牌是现代交通系统的重要部分,变丑是为桥安全评估的一个关键索引。为了完成长跨度桥,很快弄弯测量并且及时并且精确地定位桥最大值变丑,连续变丑测量系统(CDMS ) 在这基于惯性的站台被介绍并且验证纸。第一基于各种各样的桥变丑测量方法,变丑测量的方法基于纤维,眼的旋转罗盘(雾) 被介绍。第二,基本测量原则基于雾被介绍,连续曲线轨道被公式导出。然后,测量精确性在理论被分析,相关因素被介绍保证测量精确性。最后,变丑测量实验越过长江在一座桥上被进行。试验性的结果证明介绍变丑测量方法可行、实际、可靠;系统能精确地并且快速定位最大的变丑并且有广泛、宽广的应用程序前景。 | Weibing GAN Wenbin HU Fang LIU Jianguang TANG Sheng LI Yan YANG | 2016 | Photonic Sensors2016，6，1： | 4 |
| 3 | Postoperative intussusception in infants and children:a report of seven cases显示文摘Postoperative intussusception is an uncommon but serious condition in infants and children.Here,we report seven cases of postoperative intussusception in infants and children who were seen at our institution over the last 13 y.The patients showed increased nasogastric drainage,vomiting,lack of stool,and/or growing abdominal distension 2 to 9 d following abdominal surgery.Manual reduction was successful in five cases.In two cases,necro-sis was found and intestinal resection and anastomosis were carried out.No recurrence was observed at six months of follow-up.Postoperative intussusception should be suspected in pediatric surgical patients who showed signs of intestinal obstruction in the early postoperative period. | Weiwei Jiang Weibing Tang Qiming Geng Xiaoqun Xu | 2012 | The Journal of Biomedical Research2012，26，1： | 3 |
| 4 | Impact of immunization programs on 11 childhood vaccine-preventable diseases in China: 1950–2018显示文摘To evaluate the achievements of China’s immunization program between 1950 and 2018,we chose 11 vaccine-preventable diseases(VPDs)as representative notifiable diseases and used annual surveillance data obtained between 1950 and 2018 to derive disease incidence and mortality trends.Quasi-Poisson and polynomial regression models were used to estimate the impacts of specific vaccine programs,and life-table methods were used to calculate the loss of life expectancy,years of life lost,and loss of working years.The total notification number for the 11 VPDs was 211,866,000 from 1950 to 2018.The greatest number occurred in 1959,with a total incidence of 1,723 per million persons.From 1978 to 2018,a substantial decline was observed in the incidence of major infectious diseases.The incidence of pertussis fell 98%from 126.35 to 1.58 per million,and the incidences of measles,meningococcal meningitis,and Japanese encephalitis fell 99%,99%,and 98%,respectively.The regression models showed that most of the 11 diseases exhibited dramatic declines in morbidity after their integration into the Expanded Program on Immunization(EPI),while varicella and paratyphoid fever,which were not integrated into the EPI,showed increased morbidity.From 1978 to 2018,the total life expectancy for the 11 VPDs increased by 0.79 years,and similar results were obtained for different age groups.China has had great success in controlling VPDs in recent decades,and improving vaccination coverage is a key aspect of controlling VPDs in China. | Jinhua Pan Yesheng Wang Lingsheng Cao Ying Wang Qi Zhao Shenglan Tang Wenfeng Gong Lei Guo Zhixi Liu Zexuan Wen Bo Zheng Weibing Wang | 2021 | The Innovation2021，2，2： | 2 |
| 5 | Preparation and crystallization behaviour of PP/PP-g-MAH/Org-MMT nanocomposite显示文摘 | Weibing Xu Guodong Liang Hongbo Zhai Shupei Tang Guopei Hang Wei-Ping Pan | 2003 | European Polymer Journal2003，，7： | 1 |
| 6 | Whole-Aperture Pore Structure Characterization and Its Effect on Gas Content of the Longmaxi Formation Shale in the Jiaoshiba Area,Sichuan Basin显示文摘In recent years,the pore structure of shale is studied through many qualitative and quantitative techniques.Quantitative methods mainly include the low temperature gas adsorption(N2 and CO2),the high-pressure mercury injection,the small angle X-ray scattering,and the nano CT,etc.The content and adsorption ability of adsorption gas are mainly obtained by CH4 isothermal | TANG Xianglu JIANG Zhenxue LI Zhuo YANG Peipei YANG Xiao LI Weibing HUANG Hexin HAO Jin | 2015 | Acta Geologica Sinica(English Edition)2015，89，A01： | 1 |
| 7 | Impact of the national hepatitis B immunization program in China:a modeling study显示文摘Background:Elimination of hepatitis B virus(HBV)is a striking challenge for countries with high or moderate disease burden.Therefore,using China as a practical case to share experiences for similar countries may accelerate the achievement of the WHO 2030 target of 90%reduction in HBV-related incidence.We aim to evaluate the impact of national HBV immunization strategies in China;and the feasibility to achieve WHO 2030 targets under diferent scenarios.Methods:We constructed an expanded Susceptible-Exposed-Infectious-Recovered(SEIR)model and decision treeMarkov model to estimate the epidemic of HBV in China,assess the feasibility of 2030 Elimination Goals through the projections and conduct the economic analysis.Least square method was used to calibrate the expanded SEIR model by yearly data of laboratory-confrmed HBV cases from 1990 to 2018.Two models were separately used to evaluate the impact and cost-efectiveness of HBV vaccine by comparing prevalence of chronic HBV infections,qualityadjusted life-years(QALYs),incremental cost efectiveness ratio and beneft–cost ratio(BCR)under various intervention options,providing a basis for exploring new containment strategies.Results:Between 1990 and 2020,the number of chronic HBV infections decreased by 33.9%.The current status quo would lead to 55.73 million infections(3.95%prevalence)in 2030,compared to 90.63 million(6.42%prevalence)of the“Without the NIP”scenario(NIP:National Immunization Program),114.78 million(8.13%prevalence)without any interventions.The prevention of mother to child transmission(PMTCT)strategy showed a net beneft as 12,283.50 dollars per person,with BCR as 12.66,which is higher than that of universal vaccination at 9.49.Compared with no screening and no vaccination,the PMTCT strategy could save 7726.03 dollars for each QALY increase.Conclusions:Our fndings proved the HBV vaccination has demonstrated a substantial positive impact on controlling the epidemic of HBV in terms of efectiveness and economy after about 30 years of implementation of the national hepatitis B immunization program which also provided containment experience for high or medium burden countries.As for China,the next step should focus on exploring strategies to improve diagnosis and treatment coverage to reduce the burden of HBV-related deaths and ultimately eliminate HBV. | Zhixi Liu Mengying Li David W.Hutton Abram L.Wagner Ye Yao Wenlong Zhu Lingsheng Cao Shenglan Tang Jinhua Pan Yesheng Wang Qi Zhao Hong Ren Ying Wang Weibing Wang | 2022 | Infectious Diseases of Poverty2022，11，5： | 0 |
| 8 | Expert Consensus on Nutritional Support for Children with Congenital Heart Disease(2023 Edition)显示文摘The second edition of the expert consensus on pediatric nutrition was formed based on a global update of pedia-tric nutrition guidelines or consensus worldwide,the management of congenital heart disease,and the results of multi-center clinical nutrition research for congenital heart disease following thefirst Chinese consensus edition of 2016.The consensus was also shaped by the results of three discussion sessions and two questionnaires con-ducted by the 13-member collaboration group.This process was informed by both clinical guidelines and expert consensus.The quality of literature,both in English and Chinese,and the level of recommendations were evaluated using the Grading of Recommendations Assessment,Development,and Evaluations(GRADE)system. | Xuming Mo Wei Cai Jirong Qi Zhuoming Xu Ying Wang Weihui Yan Shoujun Li Nianguo Dong Xinxin Chen Jinfen Liu Qiang Shu Jimei Chen Haibo Zhang Hao Zhang Quansheng Xing Qi An Xiaofeng Li Xu Wang Yan He Junwu Su Taibing Fan Teng Ming Weibing Tang Li Hong Jinghao Zheng Ming Ye Guocheng Sun Yiqun Ding Liang Tao Yifeng Yang Zhongshi Wu Hua Cao Qiang Wang Keming Yang Libing Zhang Ping Wen Yanqin Cui Bo Zhai Yong Zou Qingya Tang Rui Chen Chun Wu Zhiyu Feng Caixia Liu Yaping Mi Rufang Zhang Ke Lin Xin Li Mingan Pi Xiangming Fan Shanshan Shi Peng Huang Zhengxia Pan Jiafeng Qi Renwei Chen Shuguang Tao Yaqin Shu Huifeng Zhang Lan Jiang Min Da Nishant Patel Liang Hu Cardiac Surgery Group of Pediatric Surgery Society of Chinese Medical Association and Parenteral Enteral Nutrition Society of Chinese Medical Association | 2023 | Congenital Heart Disease2023，18，6： | 0 |
| 9 | Small RNA sequencing revealed aberrant piRNA expression profiles in deciduas of recurrent spontaneous abortion patients显示文摘Piwi-interacting RNAs(piRNAs)is a novel class of non-coding RNAs.However,changes in piRNA expression profiles in recurrent spontaneous abortion(RSA)have not yet been investigated.The aim of this study was to identify differentially expressed piRNAs in deciduas of RSA patients.Decidua tissues were collected by curettage from recruited RSA patients and normal early pregnant(NEP)women with their informed consent.Small RNA sequencing was used to evaluate the differences in piRNA expression profiles between RSA and NEP.The present results demonstrated that the counts of total piRNA reads in RSA samples were increased compared with those in NEP samples(0.21%vs.0.11%).Differential expression analysis identified 29 upregulated piRNAs and 18 downregulated piRNAs in RSA samples.RT-qPCR further confirmed that the expression levels of uniq-109625,uniq-89328,uniq-50651 and uniq-4569 were decreased in 8 RSA tissues,compared with 13 NEP tissues.Otherwise,pi-22628 and uniq-173406 were increased in 8 RSA tissues.Based on GO term and KEGG pathway analysis,we speculate that these piRNAs regulate RSA by targeting extracellular matrix component pathway,cell adhesion pathway and focal adhesion pathway.PiRNAs may be involved in RSA pathogenesis by target genes function on adhesion and extracellular matrix component. | JIABAO WU XIAOHUA LIU LU HAN HUA NIE YUAN TANG YUNGE TANG GE SONG LIXIN ZHENG WEIBING QIN | 2022 | BIOCELL2022，46，4： | 0 |
| 10 | Influence of Heat Treatment Temperature on Microstructure and Bonding of TiO2 Film Coated on Diamond Particles Surface显示文摘TiO_2 films were coated on the surface of diamond particles using a sol-gel method. The effects of heat treatment temperature on the morphology, phase composition and chemical bond of diamond particles coated with TiO_2 films were investigated through SEM, TEM, X-ray diffraction analysis, Raman spectroscopy, FTIR, and XPS. The results showed that when being heat-treated at 600 ℃, the amorphous TiO_2 film transfered to the anatase film which bonded well with diamond substrate. Meanwhile, the Ti-O-C bond formed between TiO_2 film and diamond substrate. When being heat-treated at 800 ℃, TiO_2 film was still anatase, and partial diamond began to graphitize. The graphitizated carbon could also form the Ti-O-C bond with TiO_2 film, although TiO_2 film would tend to crack in this case. | 刘小磐 KONG Weibing XIAO Haiyan TANG Hao WAN Long HU Weida 王伟 | 2017 | Journal of Wuhan University of Technology(Materials Science)2017，32，5： | 0 |
| 11 | High-efficiency organic solar cells processed from a halogen-free solvent system显示文摘The use of non-halogenated solvents for the green manufacture of high-efficiency organic solar cells(OSCs)is important for their future application.However,the power conversion efficiency(PCE)of the non-halogenated solvent processed OSCs is generally lower than their halogenated counterpart due to the poor film microstructure caused by the solubility issue.Herein,we propose a halogen-free solvent system to optimize film microstructure of the photovoltaic blend based on the polymer donor D18and small-molecule acceptor(SMA)L8-BO towards high-efficiency OSCs.The solvent system is consisted of a main solvent carbon disulfide and an additive paraxylene,where the former ensures the good solution-processability and promotes the solution aggregation of L8-BO,and the latter can finely control the phase-separation process by selectively dissolving the SMA.This solvent combination robustly produces a high-quality active layer,i.e.,the bicontinuous networks of donor and acceptor with nano-sized phase-separation and strongπ-πstacking.With the effective charge generation,transport and collection,the resulting device from the non-halogenated solvent system shows a high PCE of 17.50%,which is comparable to that of the device prepared from the halogenated solvent chloroform(ca.17.11%).This article proposes a new strategy for the green fabrication of high-efficiency OSCs to accelerate their industrialization. | Yueling Su Zicheng Ding Rui Zhang Weibing Tang Wenliang Huang Zhichao Wang Kui Zhao Xiaochen Wang Shengzhong(Frank)Liu Yongfang Li | 2023 | Science China Chemistry2023，66，8： | 0 |
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