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| 1 | Cancer incidence and mortality in Guangdong province,2012显示文摘Objective: To estimate the cancer incidence and mortality in 2012 in Guangdong province by analyzing the cancer data of selected population-based cancer registries in Guangdong province in 2012.Methods: Eight of nine population-based cancer registries submitted cancer data to the Guangdong Provincial Centre for Disease Control and Prevention(Guangdong CDC), whose data met the data quality criteria were included for analysis. The statistics of selected registries, stratified by areas, gender, age and cancer types, were used to estimate the cancer incidence and mortality in 2012 in Guangdong province according to the population data in Guangdong province. Segi's population and the national census population in 2000 were used for calculating the age-standardized rates(ASR). Results: A total of 15,084,942 people, accounted for 17.47% of all population in Guangdong province, were covered in 8 selected population-based cancer registries in 2012. The percentage of cases morphologically verified(MV%) and the percentage of death certificate-only cases(DCO%) were 72.84% and 0.87%, respectively, and the mortality/incidence(M/I) ratio was 0.56. It was estimated that there were 211,300 new cancer cases and 117,300 cancer deaths. The incidence crude rate(CR), the ASR by Chinese standard population(ASRC) and by world standard population(ASRW), and the accumulated rate(AR)(0-74 years) were 250.20/100,000(265.39/100,000 in males, 234.29/100,000 in females), 207.04/100,000, 201.34/100,000 and 22.91%, respectively, in Guangdong province in 2012. The incidence CR and ASRC were 267.25/100,000 and 221.43/100,000 in urban areas, and 215.51/100,000 and 178.77/100,000 in rural areas, respectively. The death CR, ASRC, ASRW and AR(0-74 years) were 148.44/100,000(190.95/100,000 in males, 105.06/100,000 in females), 103.73/100,000, 102.44/100,000 and 11.68%, respectively, in Guangdong province in 2012. The death CR and ASRC were 164.57/100,000 and 105.46/100,000 in urban areas, and 124.63/100,000 and 99.97/100,000 in rural areas, respectively. Top 5 cancers were lung cancer, liver cancer, female breast cancer, colon cancer and nasopharyngeal cancers(NPC), and top 5 death cancers were lung cancer, liver cancer, colon cancer, stomach cancer, and NPC in Guangdong province in 2012.Conclusions: Lung cancer, liver cancer, female breast cancer, colon cancer and NPC were the major economic cancer burdens and health concerns in Guangdong province in 2012. Early prevention, diagnosis and treatment of different cancers, survival quality improvement and cancer burden reduction, are important issues we faced in cancer control and prevention. | Ruilin Meng Kuangrong Wei Liang Xia Yanjun Xu Wanqing Chen Rongshou Zheng Lifeng Lin | 2016 | Chinese Journal of Cancer Research2016，28，3： | 8 |
| 2 | Comparative genomic and transcriptomic analyses uncover the molecular basis of high nitrogen-use efficiency in the wheat cultivar Kenong 9204显示文摘Studying the regulatory mechanisms that drive nitrogen-use efficiency(NUE)in crops is important for sustainable agriculture and environmental protection.In this study,we generated a high-quality genome assembly for the high-NUE wheat cultivar Kenong 9204 and systematically analyzed genes related to nitrogen uptake and metabolism.By comparative analyses,we found that the high-affinity nitrate transporter gene family had expanded in Triticeae.Further studies showed that subsequent functional differentiation endowed the expanded family members with saline inducibility,providing a genetic basis for improving the adaptability of wheat to nitrogen deficiency in various habitats.To explore the genetic and molecular mechanisms of high NUE,we compared genomic and transcriptomic data from the high-NUE cultivar Kenong 9204(KN9204)and the low-NUE cultivar Jing 411 and quantified their nitrogen accumulation under high-and low-nitrogen conditions.Compared with Jing 411,KN9204 absorbed significantly more nitrogen at the reproductive stage after shooting and accumulated it in the shoots and seeds.Transcriptome data analysis revealed that nitrogen deficiency clearly suppressed the expression of genes related to cell division in the young spike of Jing 411,whereas this suppression of gene expression was much lower in KN9204.In addition,KN9204 maintained relatively high expression of NPF genes for a longer time than Jing 411 during seed maturity.Physiological and transcriptome data revealed that KN9204 was more tolerant of nitrogen deficiency than Jing 411,especially at the reproductive stage.The high NUE of KN9204 is an integrated effect controlled at different levels.Taken together,our data provide new insights into the molecular mechanisms of NUE and important gene resources for improving wheat cultivars with a higher NUE trait. | Xiaoli Shi Fa Cui Xinyin Han Yilin He Long Zhao Na Zhang Hao Zhang Haidong Zhu Zhexin Liu Bin Ma Shusong Zheng Wei Zhang Jiajia Liu Xiaoli Fan Yaoqi Si Shuiquan Tian Jianqing Niu Huilan Wu Xuemei Liu Zhuo Chen Deyuan Meng Xiaoyan Wang Liqiang Song Lijing Sun Jie Han Hui Zhao Jun Ji Zhiguo Wang Xiaoyu He Ruilin Li Xuebin Chi Chengzhi Liang Beifang Niu Jun Xiao Junming Li Hong-Qing Ling | 2022 | Molecular Plant2022，15，9： | 6 |
| 3 | Parametric Simulation and Optimization of Cold-test Properties for a 220 GHz Broadband Folded Waveguide Traveling-wave Tube显示文摘 | ZHENG Ruilin CHEN Xuyuan | | 0，，09： | 1 |
| 4 | Parametric simulation and optimization of cold-test properties for a 220 GHz broadband folded waveguide trave-ling-wave tube显示文摘 | Zheng Ruilin Chen Xuyuan | 2009 | J Infrared Milli Terahz Waves2009，30，9： | 1 |
| 5 | Parametric Simulation and Optimization of Cold-test Properties for a 220?GHz Broadband Folded Waveguide Traveling-wave Tube显示文摘 | Ruilin Zheng Xuyuan Chen | 2009 | Journal of Infrared Millimeter and Terahertz Waves2009，，9： | 1 |
| 6 | Longitudinal virological changes and underlying pathogenesis in hospitalized COVID-19 patients in Guangzhou,China显示文摘Prolonged viral RNA shedding and recurrence of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in coronavirus disease 2019(COVID-19)patients have been reported.However,the clinical outcome and pathogenesis remain unclear.In this study,we recruited 43 laboratory-confirmed COVID-19 patients.We found that prolonged viral RNA shedding or recurrence mainly occurred in severe/critical patients(P<0.05).The average viral shedding time in severe/critical patients was more than 50 days,and up to 100 days in some patients,after symptom onset.However,chest computed tomography gradually improved and complete absorption occurred when SARS-CoV-2 RT-PCR was still positive,but specific antibodies appeared.Furthermore,the viral shedding time significantly decreased when the A1,430G or C12,473T mutation occurred(P<0.01 and FDR<0.01)and increased when G227A occurred(P<0.05 and FDR<0.05).High IL1R1,IL1R2,and TNFRSF21 expression in the host positively correlated with viral shedding time(P<0.05 and false discovery rate<0.05).Prolonged viral RNA shedding often occurs but may not increase disease damage.Prolonged viral RNA shedding is associated with viral mutations and host factors. | Zhengtu Li Yinhu Li Ruilin Sun Shaoqiang Li Lingdan Chen Yangqing Zhan Mingzhou Xie Jiasheng Yang Yanqun Wang Airu Zhu Guoping Gu Le Yu Shuaicheng Li Tingting Liu Zhaoming Chen Wenhua Jian Qian Jiang Xiaofen Su Weili Gu Liyan Chen Jing Cheng Jincun Zhao Wenju Lu Jinping Zheng Shiyue Li Nanshan Zhong Feng Ye | 2021 | Science China(Life Sciences)2021，64，12： | 1 |
| 7 | Effects ofalkaline-earth fluorides and OH-on spectroscopic proper-ties of Yb3+ doped TeO2-ZnO-BaO3,based glasses显示文摘 | Xu Shennuo Wang Pengfei Zheng Ruilin | 2013 | Journal of Luminescence2013，140，： | 1 |
| 8 | Parametric Simulation and Optimization of Cold-test Properties for a 220 GHz Broadband Folded Waveguide Traveling-wave Tube显示文摘 | Zheng Ruilin Chen Xuyuan | 2009 | Journal of Infrared Millimeter and Terahertz Waves2009，30，9： | 1 |
| 9 | Parametric simulation and optimization ofcold-test properties for a 220 GHz broadband folded waveguide traveling-wave tube显示文摘 | Zheng Ruilin Chen Xuyuan | 2009 | J Infrared Milli Terahz Waves2009，30，： | 1 |
| 10 | Inhibitory of EV-A71 virus-induced apoptosis by ZVAD through ROS mediated signaling pathways显示文摘Emerging evidence that Enterovirus A 71(EV-A71)infection closely related to apoptosis.The ZVAD is a caspase inhibitor that can prevent apoptosis.The aims of this project were to evaluate the mechanism of the ZVAD inhibited EV-A71 virus and to provide experiment basis for finding new antiviral drugs.In this study,after treated with ZVAD in EV-A71 infected Vero cells,the viral replication was reduced,and the cell viability was higher than EV-A71 group.Additionally,ZVAD decreased the cell apoptosis and the level of inflammatory cytokines induced by EV-A71 in the infected Vero cells.ZVAD inhibited cell apoptosis by regulating ROS mediated signaling pathway and inflammation cytokines to achieve antiviral. | TIANTIAN XU RUILIN ZHENG DANYANG CHEN HAIYANG CHEN MINGQI ZHAO MIN GUO YI CHEN CHANGBING WANG LU KUANG YINGHUA LI BING ZHU | 2022 | BIOCELL2022，46，4： | 1 |
| 11 | Effects ofalkaline-earth fluorides and OH一on spectroscopic propertiesof Yb3+ doped Te02-ZnO-B2O3 based glasses显示文摘 | Xu Shennuo Wang Pengfei Zheng Ruilin | 2013 | Journal ofLuminescence2013，140，： | 1 |
| 12 | Construction and immunogenicity of a recombinant fowlpox virus containing the capsid and 3C protease coding regions of foot-and-mouth disease virus显示文摘 | Min Zheng Ningyi Jin Hongyong Zhang Minglan Jin Huijun Lu Minxiao Ma Chang Li Gefen Yin Ruilin Wang Qi Liu | 2006 | Journal of Virological Methods2006，，1： | 1 |
| 13 | Dietary l-arginine supplementation enhances the immune status in early-weaned piglets显示文摘 | Bie Tan Xinguo G. Li Xiangfeng Kong Ruilin Huang Zheng Ruan Kang Yao Zeyuan Deng Mingyong Xie Izuru Shinzato Yulong Yin Guoyao Wu | 2009 | Amino Acids2009，，2： | 1 |
| 14 | Parametric simulation and optimization of cold-test properties for a 220 GHz broadband folded waveguide traveling-wave tube显示文摘 | Zheng Ruilin Chen Xuyuan | 2009 | J Infrared Milli Terahz Waves2009，30，： | 1 |
| 15 | Promoting the protonation step on the interface of titanium dioxide for selective photocatalytic reduction of CO_(2)to CH_(4)by using red phosphorus quantum dots显示文摘Enhancing the selectivity of hydrocarbon in CO_(2)is a great challenge.Herein,taking widely-used and highly-stable TiO_(2)as an example,we found that the protonation step,the key step for CH_(4)production,can change from endoergic to exoergic by using red phosphorus quantum dots.Consequently,the main product in CO_(2)reduction can be shifted from CO into CH_(4).The preparation method is very simple,which just ultrasonically treating the red P in the presence of TiO_(2).With an initial rate of CH_(4)production of 4.69μmol·g^(-1)·h^(-1),under simulated solar light,it manifests a significant 49.4-fold enhancement of CH_(4)yield over TiO_(2).Density functional calculation indicates that the red P optimizes the surface electronic structure.The Gibbs free energy for CHO^(*)formation(^(-1).12 eV)becomes lower than the desorption energy of the CO(-0.01 eV)when red P is introduced.This indicates that the CO intermediates on the surface are rapidly protonated to produce CHO^(*).Subsequently,the CHO^(*)will be converted into CH_(4)instead of being desorbed from the surface to produce CO.This study demonstrates that red P quantum dot is a promising candidate for the development of efficient photocatalyst for CO_(2)photoreduction to CH_(4)under solar light irradiation. | Yinglong Lu Minghao Liu Ningchao Zheng Xi He Ruiting Hu Ruilin Wang Quan Zhou Zhuofeng Hu | 2022 | Nano Research2022，15，4： | 1 |
| 16 | Quercetin induced HepG2 cells apoptosis through ATM/JNK/STAT3 signaling pathways显示文摘Liver cancer is the seventh most common malignant tumor in the world and is the second highest cause of death due to cancer.Quercetin,a flavonoid with low toxicity,widely exists in various fruits and vegetables.It has the potential to be a therapeutic agent against various cancers.This study aimed to demonstrate the anti-tumor effect of quercetin on HepG2 cells.Quercetin suppressed the HepG2 cell proliferation in a dose-dependent manner in cell viability assay.Induction of cell apoptosis was confirmed by apoptotic cells population(sub-G1 peak)detected by flow cytometer.A decrease in mitochondrial membrane potential and caspase-3 activation were also demonstrated in this study.Furthermore,quercetin induced HepG2 cell apoptosis through ROS-mediated phosphorylated ataxia-telangiectasia mutated,c-Jun Nterminal kinases,signal transducer,and activator of transcription 3(STAT-3),and Bax signaling pathways.These results suggest that quercetin has the potential to become an effective drug against the tumor. | WANTONG LIU DANYANG CHEN JINGYAO SU RUILIN ZHENG RAN KONG BING ZHU HAO DONG YINGHUA LI | 2023 | BIOCELL2023，47，1： | 0 |
| 17 | L-Selenocystine induce HepG2 cells apoptosis through ROS-mediated signaling pathways显示文摘At present,Hepatocarcinoma is one of the main causes of tumor related death all over the world.However,there are still many clinical restrictions on the treatment of liver cancer.Recently,L-Selenocystine has been shown to be a novel treatment for tumors,especially human glioma cells.But,the mechanism of L-Selenocystine against hepatocellular carcinoma remains unclear.Therefore,the main objective of this study was to investigate the effects of L-Selenocystine on HepG2 cell proliferation and activation of reactive oxygen species(ROS)mediated signaling pathway.L-Selenocystine can significantly inhibit HepG2 cell proliferation by activating caspase-3 and cleaving PARP to induce apoptosis.Moreover,the excessive production of ROS and the influence of Bax signaling pathway which can promote cell apoptosis are key factors for L-Selenocystine to induce HepG2 cell apoptosis.Therefore,the date of this study suggest that ROS mediated signal transduction mechanism may provide certain reference significance for L-Selenocystine induced HepG2 cell apoptosis. | HAIYANG CHEN JINGYAO SU DANYANG CHEN YUYE DU RUILIN ZHENG QINGLIN DENG QIANQIAN DU BING ZHU YINGHUA LI | 2022 | BIOCELL2022，46，10： | 0 |
| 18 | Synthesis and optical properties of LiNd(PO_3)_4 nanocrystals dispersion in DMSO/TBE显示文摘Lanthanide doped nanocrystals with strong fluorescence, long lifetime at high doping concentrations have great potential application in bio-imaging and liquid gain medium. LiNd(PO_3)_4(LNP) crystal was reported to be one of the most excellent laser crystals with high Nd3+ concentration, and their nanocrystals synthesized via improved combustion method for the first time had strong emission intensity and long fluorescence lifetime of 122 μs. Besides,LiNd(PO_3)_4 nanocrystals can be dispersed in mixed solvents of DMSO/TBE(CHBr2 CHBr2) to form a transparent colloidal dispersion, and Judd-Ofelt theory was used to evaluate their optical parameters. In summary, LiNd(PO_3)_4 nanocrystals possess long lifetime(116 μs), low solvents quenching rate(4.9%), large emission cross section(7.63 × 10^(-20) cm^2) and high quantum yield(35.2%) under high Nd3+ ions concentration(1×10^(20) cm^(-3)), which would be the most competitive colloidal gain medium of optical amplification and laser with LD pump and potential biomaterial with low particles concentration. | Zhongyue Wang Zhen Yang Ruilin Zheng Kehan Yu Peng Lv Chunxiao Liu Wei Wei | 2019 | Journal of Rare Earths2019，37，6： | 0 |
| 19 | Record of a juvenile Omura's whale live stranded in Hainan Island:Evidence of a potential breeding ground in the South China Sea?显示文摘On January 12,2011,a very young juvenile Bryde's-like baleen whale was found stranded alive on the east coast of Hainan Island,in the South China Sea.Unfortunately,it died the next morning.This baleen whale showed some unique external morphology and skull features of the Omura's whale(Balaenoptera omurai).Subsequently,it was genetically identified as an Omura's whale using two different mitochondrial DNA markers.This study documents the first confirmed live stranding of a juvenile Omura's whale on Hainan Island,China.Our findings expand the known distribution range of this species in Chinese waters and may indicate that waters around Hainan Island in the South China Sea could be a potential breeding ground for the Omura's whale. | Ruilin He Xiaoling Wan Minmin Chen Fei Fan Ding Wang Jinsong Zheng | 2022 | Water Biology and Security2022，1，3： | 0 |
| 20 | Mossbauer Spectra for Ultrafine Particles Fe_(3)O_(4)显示文摘The procedure of preparing specimens of ultrafine particles (UFP) Fe3O4 was studied and themeasurement and analysis of the Mssbauer spectra at room temperature was made.After thehyperfine field due to iron was analyzed carefully,it is shown that the interaction of the interfaces be-tween grains of UFP Fe3O4 has stronger effects (enlarging the quadrupole splitting in Mssbauerspectrum) and it is found that superparamagnetic effects appear,which means that the magneticproperty of UFP Fe3O4 is different from that of bulk Fe3O4. | Haibo LI Weitao ZHENG Yudong LIU Ruilin ZHANG | 1993 | Journal of Materials Science & Technology1993，9，6： | 0 |
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